LOCUS       c00052_gnlPro..        14642 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IFAEAMAP_72.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 14:28:05
            Original ID  :: gnl|Prokka|IFAEAMAP_72
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 10919
            Orig. end    :: 25561
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14642
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[20919:24390]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13471
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14642
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14642
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             1681..2715
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MKVLYPVCIIFVLKIDMPMDILFLVGGLLLILLGANGLTDGAASV
                     AKRFHIPSIVIGLTIVAFGTSAPELTVSISSALKGSADIAIGNVVGSNTFNTLMIVGCT
                     ALFAPIAITRNTLKREIPLCILSSFALLICANDVLLDSSGENILSITDGLLLLCFFTIF
                     LSYTFAIAKRDGSMKEPEKEHLQEEDEIRLLPAWKSALYILGGLAGLIIGGNFFVDGAS
                     GIARGLGVSESIIGLTLVAGGTSLPELATSIVAALKKNPEIAIGNVIGSNLFNIFFVLG
                     CSASITPLRLTGITNFDLWVLVGSSILLWLFGIFFGKRIITRVEGSILILCYIAYTAVL
                     IYNL"
     CDS             complement(2935..3588)
                     /locus_tag="ctg52_15"
                     /transl_table=11
                     /translation="LVNLPLAQCRIAIEWLIGFVHQFEDGLTVVLGNLLGRCVFLYLEV
                     ILALDEVGDALVLVGYGVGNVDFVFHPIGILLKAHAFQMLRIVGIVINGGHGAELVESF
                     DEHTFGIEICESQRALYMCHSPFFSPFFHGANQGIGDFRIIDEVYPAEADFLFVPGLVC
                     LVVDDGSYTSYDFTFPISQEIVGFTKFECSVFLLVEGVEHVIEKVGDGIRVVFV"
     CDS             3598..4002
                     /locus_tag="ctg52_16"
                     /transl_table=11
                     /translation="MYLPILDLRMVTLITDADDQLLAVGISMPSLAEALQKAHGRLLPM
                     GWYHLAKTIFLKKYPKMLDLLLVAVKPEYQNKGVNALLFSDLIPVYQQLGFEYAESNPE
                     LELNGKVQAQWEYFKTEQHKRRRCFVKGIK"
     CDS             4138..6054
                     /locus_tag="ctg52_17"
                     /transl_table=11
                     /translation="MTLPLEEADNNITESPVSSVEYTDDNIRHLDDMEHIRVRSGMYIG
                     RLGDGSQNDDGIYVLLKEVMDNSIDEFKMGAGKRIEVTIEDSLRVSVRDYGRGIPQGKL
                     VEAVSKLNTGGKYDSKAFKKSVGLNGVGIKAVNALSSRFEVRSYRDGKVRTAIFEKGTL
                     LSDVTEDSTEESGTYIFFEPDATLFLNYSFQNQFVETLLRNYTYLNTGLTFIYNGQRIV
                     SRHGLEDLLKDNMTSEGLYDIIHLKGEDIEIAFTHTNQYGEEYYSFVNGQHTTQGGTHQ
                     TALKEHIARTIKEFYNKNQEYADIRNGLVAAIAIDVEEPMFESQTKTKLGSNNMWPAAP
                     QEHKPAGPTVNKYVGDFIKTEVDNYLHKNPLVAEVMLQKIQDSEKERKAIAGVTKLARE
                     RAKKANLHNRKLRDCRYHLSDGKGKDQETESCIFITEGDSASGSITKSRDVNTQAVFSL
                     RGKPLNSYGLTKKVVYENEEFNLLQAALNIEDGIETLRYNKVIVATDADVDGMHIRLLI
                     ITFFLQFFPDLIKKGHVYILQTPLFRVRNKKKTSYCYTEEERVKAIEELGPNPEITRFK
                     GLGEISPDEFKHFIGKDMRLEQVSLRKTDLVKELLEFYMGKNTMERQNFIINNLVIEED
                     LAS"
     CDS             6051..6509
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_18"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-18,
                     bitscore: 58.7, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRAIFPGTFDPFTIGHSSVVSRALTFIDEIVIGIGINENKNTYF
                     PLEKREQMIRDYYWNEPRIIVQSYDCLTIDFARQVDASLIIRGIRTVKDFEYEETIADI
                     NRKLTGIETILLFTEPELTCVSSTTVRELLQYGKDISMFIPEGMEIRD"
     CDS             6532..8154
                     /locus_tag="ctg52_19"
                     /transl_table=11
                     /translation="MEMMKKLFTIIICICAVTAQAQKPNNEALRKLQMAEFAITNLYVD
                     KVDEDKLVEEAIIKMLAQLDPHSTYNNAEEVKKMNEPLQGNFEGIGVQFQMIEDTLLVI
                     QPVSNGPSEKVGILAGDRIVAVNDSAIAGVKMSTEDIMSRLRGPKDSEVKLTIVRRGVD
                     DQLYFTVKRDKIPILSLDASYMIQPKTGYIRINRFGATTAEEFAEALKSLQKKGMKDLI
                     LDLQGNGGGYLNAAIDLANEFLKQKELIVYTEGRAARRSDFFAKGTGNFKNGRLIILVD
                     EYSASASEIVTGAIQDWDRGVVVGRRTFGKGLVQRPIDLPDGSMIRLTIARYYTPSGRC
                     IQKPYDSTANLDGRLTGENSQDKYNQELIDRFNHGEMIHADSIHFADSLKAQTKRMGRT
                     VYGGGGIMPDFFVPIDTTQYTDYHRNLVAKGVVIKATTGYIEKHRKELQNKYKKFEAFN
                     EKFEIDDNFLAEIRTLADKEKIKFDEKQYNQSLPLIKTQLKALIARDLWDMNEYFQVMN
                     STNQSVQQALKVLNEGIYSTIIQ"
     CDS             8330..8692
                     /locus_tag="ctg52_20"
                     /transl_table=11
                     /translation="MHSLVHTGNSHGTSPQGRRSYHIPFRILYTERGGKGKSRRRMSGR
                     KRRAAFMAICMHSVGIFIIRTLTVHQIFHSISHNKSPRYTCTYVDRIFQQTLIMFYPSG
                     NRHRHRNTDSNIGLRT"
     CDS             9068..9838
                     /locus_tag="ctg52_21"
                     /transl_table=11
                     /translation="MIFMLKGELLVNSDEYPGTTLQSRQLILQAIGSKVELLALTEVEY
                     IVYWFTELPLICEERYKEILKRSEAPLTYTPLTAISMLEGLLKSLACYLNEQPYACSKY
                     IEMKCQELVYILTCYYPLHQISTFFYPISTYTESFQYFVMQNYDKVKNVEEFAHLGGYT
                     TTTFRRLFKNMYGVPVYEWILDKKREGILNDLQYTKQRISVISARYGFDSLSHFAHFCK
                     DSFGDTPRALRKRSANGEKISIICKEQGKDQEDE"
     CDS             10001..10699
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_22"
                     /sec_met_domain="SucD_FumR (E-value: 1.9e-129, bitscore:
                     419.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALVLFLTFHMAMNLVALVSANGYNMV
                     CEFLGANWYALVATVGLAALFIIHIIYAFWLTMQNRKARGSERYAVTEKPKTVEWASQN
                     MLVLGIIVIVGLGLHLVNFWAKMQLPELMHNMGMHADTLTLAYAANGVYHIQNTFSNPV
                     FVVLYLVWLGALWFHLTHGFWSSMQSLGWNNKVWINRWKCISNIYSTIVVLCFALVVVV
                     FFAKSLCGAC"
     CDS             complement(10811..11875)
                     /locus_tag="ctg52_23"
                     /transl_table=11
                     /translation="LCNDIFTQTVDSFGEVKEYGKTGVVHAEALVAAFFGSAAGNVTRN
                     EVTECRITAFQVVVAVFLGNIFSLQCTFLQFLGIFQLLRNPDTTIVTQRFGHQSQLRLL
                     VTVNRDTSGVNLYVSRVGKPGTFTVASHCCRAVTCHCIGRKEVGIAVTTGSDYHSVGGK
                     TFQFTGNEVLCNDTAGTSVNEDNVFHFVAGIQFHSAYVHLAAQCRVCTQQQLLSGLTLG
                     IESTGYLSTTERTVVQCTAVFAGERNTLCNALVDNIVGYFSQTVNVGFAGTVVATLYCI
                     VEQTVYRVTVVLVILSSIDTTLCSDGVCTARRVLDAEVEYSETHFAQRGGSTGTGKSGS
                     YYDDVQTTFVGRVY"
     CDS             11897..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_24"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.2e-14, bitscore:
                     43.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 3.3e-38,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYEEITDVSPYENPMMIYPAIHYTMGGIWVDYELMTSIKGLFAIG
                     ECNFSDHGANRLGASALMQGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAAAEKAV
                     QEKIDWMMNIKGKKSVDSIHKELGHIMWEYVGMGRTAEGLKEGLKKLKEVRKEFEKELF
                     IPGDKEGMNVELDKAIRLYDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDE
                     NYFYVACWEYQGSDEKEPVLLKEPLVYEAIKVQTRNYKS"
     CDS             12716..13471
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_25"
                     /sec_met_domain="Fer4_7 (E-value: 2.4e-12, bitscore: 38.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 7.7e-26, bitscore: 81.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9e-07, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQKGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISEGKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFNDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNVSISNIARLNRDFIIAKLKD"
     CDS             13518..13700
                     /locus_tag="ctg52_26"
                     /transl_table=11
                     /translation="LSKLRFITQLSLYLINITRDSSAGKPPEEFFYDMPFTSDKLPARK
                     LRGEAPKFFLQKLEK"
     CDS             complement(13610..14224)
                     /locus_tag="ctg52_27"
                     /transl_table=11
                     /translation="MTDVECVCYRFSKPEFFCEDRYNHIMKEVTPPLIFYPLTITPELQ
                     LFLESSKAYLSEEKICREMLCFKRKELAFILGNYYSDYELSMLIHSLAQYTNSFHYFVL
                     QNHAKVKTVEELAQLGGYTVATFRRIFNSVFHQPVYEWMMERRKESVVYELRYTDASIS
                     EICYKYGFESLPHFSNFCKKNFGASPRSLRAGNLSEVNGMS"
     CDS             14276..14518
                     /locus_tag="ctg52_28"
                     /transl_table=11
                     /translation="MQHSSRILLTVDKHFSFQQENYNIFLTLSRRQMESSEVGSIYYCI
                     VHSLGTLSALYFTSASRRVGHRQVDLFVCCSDKNR"
ORIGIN
        1 tatcactcca ggagtattca atgcagcctc tatcaacagc tgatgtgtct tccgccacgg
       61 aacatcgtag ccaatactga cctccgaatg gataatcaat ccatactcac gggcagactg
      121 gctgtaattg accgtatggg aagacatgat gaaagagttc ggaatggtca ccacctcatt
      181 cttcggagta cggatgcggg tgacgagcgg tgttttctca atgatgttgc ccgtagtatc
      241 gttcagcttg atgcggtcac ccagcttgaa aggccgcatg taggttatga ccagtcctgc
      301 aatgatattg ccgataaccg tactggaacc gagcgaaaca atcaagccga caaacacgga
      361 gattccctgg aagactcccg acttggaacc cggcagataa gggtaaatca tggcaatcat
      421 aaacgcataa agcaagaagc gcacaatatg ataggtagga atggcccaat ccggatagaa
      481 gccgtttatc ttcagccgtt cagcctgcac ctcattggca agataacgca ccagtctgac
      541 cagatacttc accgcatagc atatcacaaa gatagtgaac agattgggta tatagtcggc
      601 tattccattc aagatgacct ttataggatt ccagatgtag gagaataatg tataagccaa
      661 gctcttggtc tgagggaaaa tggagaataa taacggaacc gtcagcagca actgcaacag
      721 catgactaca taacgcacca ggttggcaac aaacaccagc aggttgacct gcttctgcgt
      781 atccagcaat tcataatcct gaatagagat cggtttcagc ttggtatcct tcagcttctg
      841 aatgcgtagt ttgagttttc tgaacagcca gttggtaaac ttgaacaaga agaactgtcc
      901 cacaagcacc aggataaagt acaagatacg cttacccaac tgccacaagc tatgctcctt
      961 ctgcatggct ttcagtttgt ccaccacgac atgcctcttg ctggcggcca gctggtcgcg
     1021 ggtacagttt tcccacaaag catcctgatc ggtaaaggaa atgatgacct tttcgccata
     1081 catcaagtct gtaacaatat ccgtactctc taaataaaca gagtccggac gcagattgaa
     1141 acgcgtgccc aatgcttcga tgacgttgct tacatctttg gctcgctgtt ggggcgtatg
     1201 ccctccacgc ttggcataca gatagaacaa agtgtccttc tccaccacca ccggaatacc
     1261 cggtgtcacc gtccgcaacg aatcaatgcg ttgtttctgc aatgccagct tcaccgaatc
     1321 ggccgcatag cccgccaact tcatctgctc catttccatc cgcaggttcg cctcattcag
     1381 ccgggctgtt tccaactcct gccggacaag cgacaactga atcgaatcgg agtcagtcct
     1441 tgccactgtg acactcccca cactatcctc acctaaaaca ctgagcactt tatctaccaa
     1501 ctgagctgac actccgtccg ccagcatcaa cagccaacaa agaaagaaag cacggataac
     1561 cttcatatat aaacttcttg atttgattct ttaattatgc aaatataccc aataaatgct
     1621 tcaaacatac ggaatgtttt taacttccta ccctaatcga cataactttt tcatgcaaac
     1681 atgaaagttc tgtatccggt ttgcattatc tttgtactca aaattgacat gcctatggat
     1741 atattgtttc ttgtcggagg actgctcctc attcttttgg gcgccaatgg tttgacagat
     1801 ggtgccgcat ccgttgccaa acgtttccac ataccgtcca tcgtcatcgg gctcaccatt
     1861 gttgccttcg gcacttccgc accggaactc accgtcagca tatcctctgc tctcaaaggc
     1921 agtgcagaca ttgccattgg caatgtggtg ggaagcaata cgttcaatac cctgatgatt
     1981 gtgggttgta cggccctttt tgccccgata gccattaccc gtaacacact gaaacgcgaa
     2041 ataccccttt gcatcctttc atccttcgcc ctgctgattt gtgccaacga cgtcttactg
     2101 gacagcagtg gggagaacat actcagcatc accgacggcc tattgctgct atgcttcttt
     2161 accattttcc tgagttatac ttttgccatt gcaaaaaggg atggaagtat gaaggaaccg
     2221 gaaaaggagc acttacagga agaagacgaa atcaggctgt tacccgcgtg gaagtccgcc
     2281 ctatacattc tcggcggact tgccggcctc atcatcggag gtaatttctt tgtagacggt
     2341 gccagcggca tagcccgcgg attgggtgtc agcgaatcca tcatcggtct cacgctcgta
     2401 gcaggcggca cttcattacc cgaactcgcc acctccatcg tagccgcctt gaagaaaaac
     2461 cccgaaatag ccatcggaaa cgtcatcgga agtaatctct tcaatatatt cttcgtactg
     2521 ggttgttcgg cctccatcac tccactgcgt ctgacgggca tcaccaattt cgatttgtgg
     2581 gtactcgtag ggtccagcat cctgctttgg ctgttcggta tctttttcgg gaaacgcatc
     2641 atcacccggg tggaaggaag cattctgatt ctctgctaca ttgcctacac agcggtactg
     2701 atatacaacc tctaacagca aatttacaaa caccctacgc ggtattttaa agattatcac
     2761 gtatttttaa ataaggcaag ctgtacctcg gcataaaaaa taagcaagct tattttgttc
     2821 tgctctcagt ttgcattacc tttgtggtct caatattgaa caactatggc aattacaatc
     2881 aagaaagtaa ccacaagacg ggaactggag cgctttatcc gtttcaacta cctgctatac
     2941 aaaaacaacc cttattccgt ccccgacctt ttcgatgaca tgctcaacac cttcaacaag
     3001 aagaaaaacg ctgcattcga attttgtgaa gccgactatt tcctggctta tcgggaaggt
     3061 aaaatcgtag gacgtgtagc tgccatcatc aaccacaagg caaaccaaac ctggaacaaa
     3121 aaggaagtcc gcttcggctg gatagacttc atcgatgatg cggaagtctc cgatgccctg
     3181 attcgcaccg tggaagaatg gggaaaagaa cggggaatga cacatataca aggcccgctg
     3241 ggattcacag atttcgatgc cgaaggtatg ctcatcgaag gattcgacca gctcagcacc
     3301 atggccacca tttataacta tccctactat ccgcaacatc tggaacgcat gggctttgag
     3361 aaggatgccg attgggtgga atacaaaatc tacattcccg acgccatacc cgacaagcac
     3421 aagcgcatct ccgacctcat ccagcgcaag tataacctca aggtaaagaa atacacatct
     3481 gccaagaaga ttgcccaaga ctacggtcag gccatcttcg aactgatgaa cgaagcctat
     3541 cagccactct atggctattc tgcactgagc caacggcaga ttgaccaata cttcaagatg
     3601 tacctgccca tcctcgacct acgcatggtg acattgatta ccgatgccga tgaccagctg
     3661 cttgccgtag gcatttccat gccgtcactc gccgaagcgt tgcaaaaagc ccacgggcgc
     3721 ctgcttccta tgggttggta tcacctggcc aagaccatct tcttgaagaa atatcccaag
     3781 atgctcgatt tgctgctggt tgccgtgaaa ccggagtatc agaacaaggg ggtaaatgca
     3841 ttgttgttct ccgaccttat ccccgtctat cagcaacttg gtttcgagta tgccgagagt
     3901 aatccggagc tggagctgaa cggcaaggtg caagcgcagt gggagtactt caagacggaa
     3961 cagcataaac ggagaagatg ctttgtgaaa ggaataaaat aagttctaaa tccagaatat
     4021 aagcttgtca gaagtccata aaagacatta tttttttgcg aacccccgaa tttctcatta
     4081 cctttgtcgc aatgcgcaat atgaaggaat aacgtactta tggaagataa caacaatatg
     4141 accctgccgc tggaagaagc agacaacaat atcacagaga gccccgtttc cagcgtggaa
     4201 tataccgacg acaacatccg ccacctcgac gacatggaac atatccgtgt ccgttccggt
     4261 atgtacatag gccgtctggg cgacggctca cagaacgatg acggcatcta tgtgttgctg
     4321 aaagaagtga tggacaacag catcgacgag ttcaagatgg gtgccggaaa gcgtatagaa
     4381 gtgactatag aagacagtct gcgtgtcagc gtacgcgact atggacgagg cattccgcaa
     4441 ggcaaactgg tagaggcggt cagcaaactg aataccgggg gtaaatatga ctcgaaggct
     4501 ttcaagaaaa gtgtcggact gaacggcgtg ggcatcaagg cggtcaatgc gctgagtagc
     4561 cgtttcgagg tacgcagtta ccgcgacggc aaagtacgta ccgccatctt cgagaaagga
     4621 acgctgttga gtgatgtgac cgaagactcg acagaagaaa gcggaaccta tatcttcttc
     4681 gaaccggacg ccacactctt cctgaactat tccttccaga accagttcgt agaaaccctg
     4741 ctgcgcaact acacctacct gaatacgggc ctcaccttca tttacaacgg ccagcgcatc
     4801 gtttcccgcc acgggctgga ggacttgctg aaagacaaca tgaccagcga aggcctttac
     4861 gacatcatcc acctgaaagg agaggacatc gagattgcct tcacacacac caaccaatac
     4921 ggcgaagagt actactcctt tgtcaacggg caacacacca cccaaggcgg cacacaccag
     4981 actgccttga aggaacacat tgcccgtacc atcaaggagt tctacaacaa gaaccaggaa
     5041 tatgccgaca tccgcaacgg actggtagcc gccattgcca tcgacgtgga ggaacccatg
     5101 ttcgagagcc agaccaaaac gaaactgggc agcaacaaca tgtggcctgc cgcgccgcag
     5161 gaacacaagc ccgccggccc cacggtgaac aaatacgtag gagacttcat caagacggaa
     5221 gtggacaact acctccacaa gaacccgctt gtggccgaag tgatgctgca aaagatacaa
     5281 gactccgaga aagagcgcaa agccattgcc ggcgtcacca agctggcacg cgaacgcgcc
     5341 aagaaagcca acctgcacaa ccgcaagctg cgcgactgcc gctaccactt gagtgacggt
     5401 aaaggcaaag accaggaaac cgaatcctgc atcttcatta ccgagggaga ctctgccagc
     5461 ggttccatca ccaagagccg cgacgtgaat acccaagcag tattcagcct gcgtggtaaa
     5521 ccgctaaatt cctacggact caccaagaaa gtagtttatg aaaacgaaga attcaacttg
     5581 cttcaagcag ccttgaatat agaagacggc atagagacac tgcgctacaa caaagtcatc
     5641 gtagctaccg atgccgatgt ggacggcatg cacatccgcc tgctcatcat caccttcttc
     5701 ctgcagttct tccccgacct gataaagaaa gggcatgtat atatcctgca aacccctctc
     5761 ttccgcgtgc gcaacaaaaa gaagacaagt tattgctata cagaggagga acgtgtgaaa
     5821 gccattgaag aactgggtcc caaccccgaa atcacccgat tcaaaggtct gggagaaatc
     5881 tcgcccgacg agttcaagca ttttatcggc aaggatatgc gtctggaaca agtgtccctg
     5941 cgcaagacag acctcgtaaa agagctgctg gaattctaca tgggtaagaa taccatggaa
     6001 cgacaaaact ttattatcaa caacttggtt atagaagaag atttggcatc atgagaagag
     6061 ctatctttcc gggaacattc gacccgttta ctatcggaca ctcttcggta gtgagccgtg
     6121 cactgacttt tatagacgaa atcgtcatag gcatcggcat caatgaaaat aagaatacgt
     6181 atttcccctt ggaaaagcgc gaacaaatga tacgagacta ctactggaac gagccgcgca
     6241 tcattgtgca gtcctatgac tgcctgacta tcgactttgc ccggcaggta gatgccagtc
     6301 tgataatacg cggcatacgc accgtgaagg atttcgaata cgaggaaacc attgccgaca
     6361 tcaaccgcaa actgaccggc atagaaacca tcctgctctt caccgagcca gaacttacct
     6421 gcgtcagttc caccaccgtg cgcgaactgc tgcaatacgg caaggacata agcatgttca
     6481 taccggaggg aatggagatt agggattaag gataaaggat tagggattaa aatggaaatg
     6541 atgaaaaaac tatttactat tataatatgt atatgcgcgg tgacggcaca agcgcaaaag
     6601 ccgaacaatg aagccctgcg caaactgcaa atggcagagt ttgccatcac caacctttat
     6661 gtggacaagg tggatgaaga caaactggtg gaagaagcca tcatcaagat gctggcacaa
     6721 ctcgacccgc actccaccta caacaacgcc gaagaagtga agaagatgaa cgagccgttg
     6781 caaggcaatt tcgagggcat cggcgtacag tttcagatga tagaagatac cctgcttgtg
     6841 atacaacccg tgagcaacgg accttccgag aaggtgggca tccttgccgg cgaccgtatc
     6901 gtagccgtca atgacagcgc cattgccgga gtaaaaatga gcacggaaga tattatgagc
     6961 cgcctgcgcg gaccgaaaga ctcggaagtg aaactcacca tcgtgcgccg tggcgtggac
     7021 gaccagctgt acttcaccgt gaagcgtgac aaaattccca tcctcagcct ggacgcatct
     7081 tacatgatac aacccaaaac cggctatatc cgtatcaacc gcttcggggc aaccaccgcc
     7141 gaagagtttg cagaagccct gaaaagcctg caaaagaaag gaatgaaaga cctcatcctc
     7201 gacctgcaag gaaatggagg agggtatctg aatgccgcca tcgaccttgc caacgaattt
     7261 ctgaagcaaa aagaactcat cgtctacacc gaaggaaggg ccgcacgccg cagtgatttc
     7321 tttgccaaag gtacgggcaa cttcaagaac ggccgtctca tcatattggt ggacgagtac
     7381 tccgcttctg ccagtgaaat cgtgaccgga gccatccagg actgggacag aggcgtggta
     7441 gtaggacgcc gcaccttcgg caagggatta gtacagcgtc ctatcgacct gccggacggt
     7501 tccatgattc gcctcactat cgcccgctac tatactcctt cgggccgttg tatccagaag
     7561 ccttacgaca gcaccgccaa cctcgacggc cgcctaaccg gcgagaacag tcaggataag
     7621 tataaccagg aactgataga ccgcttcaat catggagaaa tgattcatgc ggacagtatc
     7681 cattttgccg actccctgaa agcacagacc aagcgtatgg gacgtaccgt ttacggaggt
     7741 ggaggtatca tgcccgactt cttcgtcccc atcgacacta cccagtacac agactatcac
     7801 cgcaacctcg tagccaaagg cgtggttatc aaagccacta ccggctacat cgagaagcac
     7861 cggaaggagt tgcagaacaa atacaagaaa ttcgaagcct tcaacgagaa gttcgagata
     7921 gacgataact tccttgccga aatacgtacg cttgccgaca aagagaaaat caagtttgac
     7981 gagaaacagt acaaccaatc cctaccgctc atcaagacac aacttaaagc cttgatagcc
     8041 cgtgacctat gggacatgaa cgaatacttc caggtgatga acagcacgaa ccagagcgtg
     8101 cagcaagctc taaaagtgtt gaacgaaggc atctacagca ctattatcca atagccgact
     8161 tgaaacaaac ttaggcgcgg attatgcgga tttagtttat ctaattccgc gtaattcgcg
     8221 cctaaaatca ttctccgaac agccacttat tcagccactt gttgacgtag atgttgacca
     8281 cagcacatcc agcaccgatt gcagcccccg ccaacacatc cgacggataa tgcactccct
     8341 cgttcatacg ggaaactccc acggaacaag cccacagggc agacggagct atcacatacc
     8401 atttaggata ctttacactg agcgaggtgg caagggcaaa agccgtcgcc gtatgtccgg
     8461 aaggaaaaga cgggctgcct tcatggctat atgcatgcac tctgtcggga tatttatcat
     8521 aaggacgctc acggtccacc agatatttca ttccataagt cacaacaaaa gcccccgcta
     8581 cacttgtacc tacgtagacc gcatctttca gcaaaccctt atcatgtttt atccaagcgg
     8641 caaccgccat cgccaccgga acaccgacag caacataggg ctccgaacgt gaaattatct
     8701 tattatagtt acggacaaac ttgccatccc aactgttaac ccggtgcaaa gtgttaatat
     8761 cccaattctg tgccgaaaga ccggatacaa caaggcagat aaaatataca aaaaaaatag
     8821 cctttttcat aagtccttta tattagtttg acgcaaagat aggacaaata gatagagttt
     8881 tcacaaaaaa attctatctt tgttgccaca tttataataa ttcgctaatc atttcatgag
     8941 actggaaact tgctgcaacc gacagattga ttgtatggta tgtccccaaa aatcagaagg
     9001 agtattggtt taccgccact accccaaggg acaacatttc tctgctgaaa agtgcacaca
     9061 gaactgcatg atatttatgc tgaaaggtga attacttgta aacagtgacg aatatccggg
     9121 caccactctc caaagccgcc agctcatctt gcaagccatc ggctccaaag tagaactcct
     9181 ggctttgacc gaagtggaat atattgtcta ttggttcacc gagcttcctc tgatttgcga
     9241 agagcgctac aaggagatac tgaaacgctc ggaagccccc ttgacttata ccccgcttac
     9301 cgcgatttcc atgctcgaag ggctcctgaa aagccttgcc tgctacctca acgagcaacc
     9361 ctatgcgtgc agcaaataca ttgaaatgaa atgccaggaa ttggtataca tattgacatg
     9421 ctactatccg ctacaccaaa tcagtacatt cttctacccc atcagcactt atacggaaag
     9481 cttccaatat ttcgtcatgc agaactacga caaggtgaag aatgtggaag agtttgccca
     9541 cctcggtgga tataccacca ccacattccg ccgtctgttt aaaaatatgt atggggtccc
     9601 ggtctatgaa tggattctgg acaagaaacg tgaaggaatt ctgaacgacc tgcaatacac
     9661 caaacaacgc atttcagtca tcagcgcccg ctatggcttt gattccctat cccactttgc
     9721 ccacttctgc aaagactctt tcggagacac gccccgcgcc ctgagaaaac gttcagcaaa
     9781 cggagaaaag atttccatta tctgcaaaga gcaaggcaaa gaccaggagg acgagtaaac
     9841 cttttacttg tccgtaaact tcgcattctg ccggattacg gaattatttc tttaatcgct
     9901 tgctttatcg ctggatttct cctatttttg cgaaacattt acagaagtat cctgatagaa
     9961 caaattttca aactattaaa taacttaaat tcaatcattt atgtggttaa gtaattcatc
    10021 tgtaggaagg aaagtggtga tgagcgttac cggtatcgcc cttgtcctgt ttctgacatt
    10081 tcacatggcg atgaacctgg ttgcattagt ctcggctaat ggctacaaca tggtttgtga
    10141 gttcctggga gcaaactggt acgcattggt ggctacggta ggtctggctg ccttattcat
    10201 catccacatc atctacgctt tctggctgac tatgcagaac cgtaaggcac gtggtagcga
    10261 acgctatgcc gttacggaaa agcccaagac tgtggaatgg gcttctcaaa acatgctcgt
    10321 actgggtatc atcgtaatcg tgggtttggg cctgcacctg gtaaacttct gggctaaaat
    10381 gcagcttccc gagttgatgc acaacatggg catgcatgct gacaccctca cgctggcata
    10441 tgcagccaac ggtgtctatc acattcaaaa caccttcagc aatccggtat tcgtagtgct
    10501 ttacctcgtt tggctgggcg cattgtggtt ccacctcact cacggtttct ggagctccat
    10561 gcagtcttta ggctggaaca acaaagtatg gattaaccgt tggaaatgta tctccaacat
    10621 ctattctact atcgttgtcc tctgcttcgc tctggtagtt gtcgtattct ttgcaaaatc
    10681 attgtgcggc gcttgctaaa ttcaaattgt aaatgactaa attgtaaatt gcattatgac
    10741 taagatagat tctaaaatac cggaaggacc ggtggctgag aaatggacca attataaggc
    10801 tcaccaaaaa ttagtaaacc ctgccaacaa acgtcgtctg gacatcatcg tagtaggaac
    10861 cggacttgcc ggtgccagtg ctgccgcctc tctgggcgaa atgggtttca gagtattcaa
    10921 cttctgcatc caggactctc cgcgccgtgc acactccatc gctgcacaag gtggtatcaa
    10981 tgctgctaag aattaccaaa acgacggtga ctctgtatac cgtctgttct acgatacagt
    11041 aaagggtggc gactaccgtg cccgcgaagc caacgtttac cgtctggctg aagtatccaa
    11101 caatattatc gaccaatgcg ttgcacaagg tgttcctttc gcccgcgaat acggcggtac
    11161 actggacaac cgttctttcg gtggtgctca ggtatcccgt actttctatg ccaagggtca
    11221 gaccggacag cagctgttgc tgggtgcata ctctgcattg agccgccagg tgaacgtagg
    11281 cactgtgaaa ctgtataccc gctacgaaat ggaagacgtt gtcctcattg acggacgtgc
    11341 ccgcggtatc attgcaaaga acctcgttac cggtaaattg gaacgttttg ccgcccacgc
    11401 tgtggtaatc gctaccggtg gttacggcaa tgcctacttc ctttctacca atgcaatggc
    11461 atgtaactgc tctgcagcaa tggcttgcta ccgtaaaggt gcctggtttg ccaaccctgc
    11521 ttacgtacag attcacccca cttgtatccc ggttcacggt gacaagcagt ctaagctgac
    11581 tttgatgtcc gaatctctgc gtaacgatgg tcgtatctgg gttccgaaga agctggaaga
    11641 tgccaagaaa ctgcaggaag gtacactgca aggaaaagat attcccgagg aagaccgcga
    11701 ctactacctg gaacgccgtt atccggcatt cggtaacctc gttccgcgtg acgttgccag
    11761 ccgcgctgcc aaagaacgct gcgacaaggg cttcggcgtg aacaacaccg gtcttgccgt
    11821 attccttgac ttctccgaag ctatcaaccg tctgggtaaa gatgtcgttg cacaacgtta
    11881 cggcaacctc ttcgatatgt atgaagaaat cactgatgtc agcccatacg aaaacccgat
    11941 gatgatttat ccggctatcc actataccat gggtggtatc tgggttgact acgaactgat
    12001 gacctccatc aagggactgt tcgccatcgg tgaatgtaac ttctccgacc acggtgcaaa
    12061 ccgcctcggt gcttccgccc tgatgcaagg tctggccgat ggttacttcg tattgcctta
    12121 cactatccag aactatctgg ccgaccagat tacagttccc cgtttctcta ccgacctgcc
    12181 cgaatttgca gctgcagaaa aggccgttca ggagaagatt gactggatga tgaacatcaa
    12241 gggtaagaag tctgtagact ctatccacaa ggaactgggc cacattatgt gggaatatgt
    12301 aggtatggga cgtacggccg aaggcttgaa ggaaggtctg aagaagctga aagaagtccg
    12361 caaggagttc gagaaagaac tgttcatccc gggcgacaag gaaggtatga atgtagaact
    12421 cgacaaggct atccgtctgt acgacttcat cactatgggc gagctggttg cttacgatgc
    12481 actgaaccgt aacgaaagct gcggcggtca cttccgtgaa gaatatcaga ctgaagaagg
    12541 cgaagccaag cgtgacgatg aaaactactt ctacgtggct tgctgggaat atcagggttc
    12601 tgacgaaaag gaaccggtat tgctgaaaga gccgctggtt tacgaagcaa tcaaggtaca
    12661 gactcgtaac tacaagagct aatcgggaag ttgaacattt aaagaattaa agaaaatgga
    12721 taaaaatata tcatttacgc tcaaggtatg gcgccagaag ggtccgaaag caaaaggcgc
    12781 ttttgaaaca taccaaatga aagatatccc gggcgatact tcattcctcg aaatgctgga
    12841 tatcttgaac gaacagctga tttctgaagg taaagaaccg gttgtattcg accacgactg
    12901 ccgcgaaggt atctgcggta tgtgttcgct ctacatcaac ggacatcccc acggtcctgc
    12961 aaccggcgct acgacttgcc agatttatat gcgtcgtttc aacgacggcg ataccatcac
    13021 tgttgaaccg tggcgctctg ccggtttccc ggttatcaag gacttgatgg tcgaccgtac
    13081 ggcctacgac aagattatgc aggcaggcgg ctacgtcagc gtacgtaccg gtgctcccca
    13141 ggatgccaac gctatcctga ttccgaagcc catcgctgac gaggctatgg atgctgccag
    13201 ctgtatcggt tgtggtgctt gtgtggctgc ttgtaagaac ggttctgcta tgctgttcgt
    13261 ttctgccaag gtgagccagc tgaacctgtt gccccaaggc aaaccggaag cattgcgccg
    13321 tgccaaggct atgttgagca agatggacga actcggtttc ggtaactgta caaacactcg
    13381 tgcgtgcgaa gctgaatgcc cgaagaatgt ttccatcagc aacattgctc gcctgaaccg
    13441 cgactttatc attgcgaaac tgaaagacta atccggtctt tctgcaaata atataggatg
    13501 cgcttcggat aaaccttttg agcaagctca gatttatcac tcagctttca ctatatttga
    13561 ttaatatcac aagagactcc tctgccggga aaccgccgga ggagtttttt tatgacatgc
    13621 cgtttacttc agataaattg ccggcacgca agctacgggg agaagccccg aaattctttt
    13681 tgcagaaatt ggaaaaatga ggcagcgatt caaagccata tttatagcaa atctctgata
    13741 tagaagcatc cgtataacga agttcataaa ccacgctttc cttcctccgt tccatcatcc
    13801 actcgtacac cggttgatga aaaacagaat tgaatatacg ccggaaagta gctactgtat
    13861 atcctcccaa ctgggcaagt tcctctaccg tcttgacttt ggcatgattc tgcaagacaa
    13921 agtagtgaaa ggaattagta tactgggcaa gagaatgtat cagcatggaa agctcatagt
    13981 cggagtagta atttccaaga atgaaagcaa gttctttccg tttgaaacaa agcatttccc
    14041 ggcaaatctt ctcctcggac aaataggcct tggaactttc cagaaagagc tgcaactcgg
    14101 gagtaatggt caaaggatag aatatcaatg gaggggtaac ctctttcata atatggttat
    14161 accggtcctc acagaagaat tcaggcttac tgaaccggta acaaacgcat tccacatccg
    14221 tcatggcaag tatttcgtac ttggaaccaa tagcttgaag gatgaactca cctgcatgca
    14281 acacagttcc cgcatactcc ttactgttga caagcacttc tcctttcagc aggaaaatta
    14341 taatattttc ctcacacttt cgcgccggca gatggaatcc tctgaggtgg gaagcatata
    14401 ttattgcatt gtccacagcc ttgggacatt gagcgcattg tattttacct ctgcaagcag
    14461 aagagttggg catcggcaag tagatttgtt tgtttgttgc agtgacaaaa atagataaat
    14521 acgcgagttc gggataagaa aagctttaga aaagttccaa ttgccttgat ttctctacgt
    14581 gtaccggcag tgcttccggc ttattgtcaa agaaacaata ggctgtaaga gcggagcaca
    14641 ag
//
