LOCUS       c00016_gnlPro..        13689 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DNDIJGHA_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 16:19:38
            Original ID  :: gnl|Prokka|DNDIJGHA_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 21597
            Orig. end    :: 35286
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13689
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[31597:35087]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13490
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13689
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13689
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(448..1038)
                     /locus_tag="ctg16_22"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPILVQRIFQSDQQNEAKAAAE"
     CDS             1365..2888
                     /locus_tag="ctg16_23"
                     /transl_table=11
                     /translation="VALVGPNGAGKSTLFRMILGEDTPDEGSISMDEYAIVGYLPQEAS
                     EPKDETVLEIALGITPEMEQAIHTIRTAENANKTDTPEYAEAIDTFNAANGYQLEPKAK
                     KILKGLAFRESDFHRPAREMSGGWIMRAYLAKLLVLEPDLLMLDEPTNHLDLLSLLWLQ
                     RYLKNYPGAILMISHDRDFMDELVESVYDIDNEELVEYRGNYSDFLQQKDVRFEQLQAA
                     YRNQQKEIAHIQEFIDRFRSINSKAGQVQSRIKQLEKMKIIQKPVARRKVFKFNFPQPP
                     RSTQKVIELEKVCQSYGDRRVYENLDLLVERGERTVLVGPNGAGKSTLLKILAGIIPID
                     SGQRTPGTTTRIGYFSQARTENLNPENTVLEEIMKCSAEIREEEARSILGSFLFRRLDV
                     EKRVSVLSGGEKSRLSLVKFLVDPPNLLLMDEPTTHLDLLSVEALVQALKHYEGTLVFI
                     SHDVHFIRSLAQKTLHVNRGTITAYAGGYDYYLEKSGILDDEKGGITAE"
     CDS             2952..3470
                     /locus_tag="ctg16_24"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQALAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             3599..4345
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_25"
                     /sec_met_domain="adh_short_C2 (E-value: 1.4e-75, bitscore:
                     245.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSCGG
                     AAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLRMK
                     EEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKAGL
                     IGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDIAA
                     LTAFLASDDARYITGQVIACDGGMTM"
     CDS             4696..5574
                     /locus_tag="ctg16_26"
                     /transl_table=11
                     /translation="MVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWE
                     LYTAFMENGRPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMS
                     HHAASKFCEWLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSN
                     DRYQKTGSKKPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVR
                     GGSWEDDPDSLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTM
                     HRLWNFSKGEP"
     CDS             5588..5788
                     /locus_tag="ctg16_27"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAIHGSRIVGKHR"
     CDS             complement(5965..6159)
                     /locus_tag="ctg16_28"
                     /transl_table=11
                     /translation="MRDSCPPEGTEFPGAGGRIRFFRHGGNLLETFLRRSTGKLFLYRK
                     MPSNSAARFSSIWYTAAFT"
     CDS             complement(6252..6962)
                     /locus_tag="ctg16_29"
                     /transl_table=11
                     /translation="MGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGLGSSSLAPSDS
                     SSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNTGTTAAGINLT
                     FSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGIAAPTANTEGDTVT
                     ISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEMVPEPATVSLG
                     LLGLAALMMRRLRA"
     CDS             7307..8014
                     /locus_tag="ctg16_30"
                     /transl_table=11
                     /translation="MNKLLSNLILSTGMSLSATAATSLLDSSIVGYSDFASQTADFGTR
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSVTYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             8269..8676
                     /locus_tag="ctg16_31"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9525)
                     /locus_tag="ctg16_32"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg16_33"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDNTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_34"
                     /sec_met_domain="SucD_FumR (E-value: 1.6e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_35"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.5e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 7.2e-38,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12723..13490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_36"
                     /sec_met_domain="Fer2_3 (E-value: 1.4e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 4.5e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.6e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(13504..13608)
                     /locus_tag="ctg16_37"
                     /transl_table=11
                     /translation="MRKQLSGILFLVQGNLVMKKLPTADAAGSFYRAS"
     CDS             complement(13605..13688)
                     /locus_tag="ctg16_38"
                     /transl_table=11
                     /translation="VSSGIAKYGLLDYWVPSGVTIFYAARR"
ORIGIN
        1 aacaagaaaa tctcttgatt tctacttgcc accatttaca ttggtgccag caaacctccg
       61 tggatgcgga ggttccagta gttaacaaac actgtattta attcgaatta tgaagaacat
      121 cgctatcctc gccatcgccg gcgccgcttg cctggtcgct tcctgctccc agcagcagca
      181 gcaacagcaa accaccgctc ctgctcccgc tccggttgtg caggccaagg gcaagtaagt
      241 ttgcagcggg gttttgccct gcaacactag caaattatcc aattaatccg cactcggtgt
      301 acgcactgag tgcgttttta tttgccctga gtccggattc cctccgccat ttgccgattc
      361 gccgggattt tccttaaaaa cggcggatac cgcaaaccgc cgcggcgcag caccgtgtgc
      421 cggttcctgc cggatcaggc ttccccttta ttcagcggcc gccttcgcct cattctgctg
      481 atcggactgg aatatccgct gaaccagaat ggggcgtttc ctggcccacc cgggccagac
      541 caggtgatgt tccatgccgt aggaatggcc ctccggaaag gccttggaaa caaatggttc
      601 ccgccagtcc tcctcccatt tgccgccttc ccggtccttc tgggtcagcg tcaccagatg
      661 cccgcagttc ttccaggcat ccagaacaat ggagccctgc aatcccttcc ccgcggcatt
      721 gacatacacg caactgtgct ccctgcccgt tccacggtct cgaatcgtca gccctatgcg
      781 gaaatacttc acggggcggc ggcgcaggtc ccggtacaaa tcctgctgga cctgccagca
      841 cagccccctg tcgcgcaggt tggaattgac cagaatattg ttcagccagc caaacagcac
      901 agtcctgttg tcccgggcaa tcgctgcgga ctggaccaca gccgtgtccg ccagccacct
      961 ggcctccgct ccggcagcgg gaagagaggc ctgatccggc ggcagcagcg ccaggaaggc
     1021 attagccagc ccggacattt gctgctgcac gtaagtttgt tgtatataat cctccgccgg
     1081 aggagtacag caggaactcc atccgcacaa aagggcggca gcaagcaaaa gcctgaatgt
     1141 ctgcgtggtc ggcatggcgc gccaaggcta gcagactacg cgtaaaaatc cagtaaagct
     1201 ttcaaaaatg cctgcctccg ccctgacggc tcttgccttc ccctttccat cccggtagaa
     1261 tacatcctct cttcaccatg ctgacgatca aaaatctcac aaaatcccac gccggacgga
     1321 ccttgttcag ggaaacggaa atgaccatta actgggggga acgggtggct ctggttggcc
     1381 ccaacggagc aggcaaatcc accctgttcc gcatgattct gggagaagac acgccggacg
     1441 aaggctccat cagcatggat gaatacgcca tcgtgggcta tcttccccag gaagccagcg
     1501 aaccgaagga tgaaaccgtt ctggaaatcg ccctgggcat cacgccggaa atggaacagg
     1561 ccatccacac catccggacg gcggaaaacg ccaacaaaac ggatacgccg gaatacgcgg
     1621 aagccattga cactttcaac gccgccaacg gttaccagct ggagcccaaa gccaagaaaa
     1681 ttctcaaagg gctggccttt cgggaaagcg acttccatcg ccccgcccgg gaaatgtccg
     1741 gcggctggat catgcgcgcg tacctggcca agctccttgt cctggagccg gacctcctga
     1801 tgctggacga acctaccaac cacctggacc tcctgtccct gctgtggctc cagcgatacc
     1861 tgaaaaacta ccccggagcc atcctgatga tttcccacga ccgggatttc atggatgagc
     1921 tggtggaaag cgtgtacgac atcgacaacg aagaactggt ggaataccgc ggcaattact
     1981 cggacttcct ccaacaaaag gacgtgcgct tcgagcagct tcaggcggcc taccgcaacc
     2041 agcagaagga aatagcgcac attcaggaat ttattgaccg tttccgctcc atcaattcca
     2101 aagccgggca agtccagagc cgcatcaagc agctggaaaa gatgaaaatc attcaaaaac
     2161 cggtagcccg caggaaagta tttaaattca acttccccca gcctccgcgc agcacccaga
     2221 aagtcattga gctggaaaaa gtctgccaat cctatggcga ccgcagggtt tatgaaaacc
     2281 tggacctgct ggtggaacgc ggggagcgca ctgttcttgt aggcccgaac ggcgcgggca
     2341 aatccactct tctcaaaatc ctggcgggca tcatccccat tgactccgga caacgcactc
     2401 ccggtaccac gacgcgcatc ggctacttct cccaggcgcg aacggaaaac ctgaatccgg
     2461 aaaataccgt gctggaggaa atcatgaaat gcagcgctga aatccgggag gaagaagcgc
     2521 gttccatcct gggttccttc ctgttccgga ggctggatgt ggaaaaacgc gtcagcgttc
     2581 tttccggcgg ggaaaaatcg cggctcagcc tggtcaaatt cctggtggat ccgcccaacc
     2641 tcctgctgat ggacgagccg accacccacc tggacctttt gtccgtagaa gccctggtgc
     2701 aggctctgaa gcattatgaa ggaacactgg tcttcatctc ccacgatgtg cacttcatcc
     2761 gttccctggc acaaaaaacc ctgcatgtga accgggggac catcaccgcc tacgcaggtg
     2821 gatatgacta ctatctggaa aagtcaggca ttctggacga tgaaaaaggc ggcatcacgg
     2881 cggaataagg ctcttttttc agtttcccct ttttccttgc cgtggatttc atcctgcctt
     2941 aaaagaacag gatgaaggct tttcttgttc ctctcttata ttctgcgctt ctgtccggag
     3001 cctctcttgc atttggtgaa acggccgccg gaacggcttc ccccgcagca gcggctccgg
     3061 cggaaaaaat tccttccgcg gaatccctga tcaaccaggc cttttccttt gccatcaata
     3121 tccagcaggc gttggcaggc gttcaggaca aggaaagcgc ggacaacgcc gtcaaaacgc
     3181 tgcaggacat tcagaaggac atccggcatt tcctccagct tcaggataaa ttgaacgatg
     3241 cggaaaagga gaaagaagac gccttgatag aaaaaatgga aaaacgaatg gaaatgctgg
     3301 acaaccgctg caggcaggaa ggcaaacgcc tgtttgaggc ccgctattac ggttccgccg
     3361 ccttaaagga cattttggaa aattcggatg aattcagcga cctggtagaa ccggatgaag
     3421 acggggcgcc ccccggtgca ctccgggaaa atgaagaggc cggacagtag ccccccgccc
     3481 cgtttctccc cccctctttt ttcattcccg gcacgcccct tccccgtatg ggttcctgcg
     3541 cggccaagtc catttcaagc ttgccggaac cgtgaaaaac gggtttactg tgggcagcat
     3601 gcaaaagtta gcaggtaaaa cagccatcgt taccggcgcg ggccgcggaa tcggcaatgc
     3661 cgtcgcgcgc cgcttcgctt cggaaggagc cagggtcatc ctgatcagcc gcagtccatc
     3721 cagctgcggg ggggccgcag aagaaatcaa caaggaattt ccggattcct gcaaggccta
     3781 cccctgcgac gtagcggatt acgcggccgt tcaggaaacc atggccgcca ttttgaaaga
     3841 cttcccgcag attgacatcc tggtgaacaa cgccggcatc acgcgggact ccctgatgct
     3901 ccgcatgaaa gaggaagact gggatgccgt tctggacacc aacctgaaaa gcgcgttcaa
     3961 tacggtcaag gccctccagc gcgttctcat gaaatccccg gccgggcgca tcatcaacat
     4021 gagctccgtc atcggtctcg tcggcaacat cggtcaggcc aattacgccg cttccaaggc
     4081 gggcctcatc ggtttcacca aatcactggc tcaggaattc gctccgcgca aagtcacgtg
     4141 caacgccatt gctcccggct tcatctccac ggaaatgtcc aatgccattc ccgacaatct
     4201 caaggaagaa atcgttaaga aaataccttt gaaagaacaa ggttccgtgg aagatatcgc
     4261 cgccctgacg gccttccttg cctctgacga tgcccgttac atcaccgggc aggtcattgc
     4321 ctgcgacgga ggcatgacga tgtagggcat tccggttttc tccattccat gcgcggcatt
     4381 ttccttgttt cctgctttct gggaggaagc gccctgctgg ccgggtgccg ggaagaaaat
     4441 aattcccccc gcccggccac ggaagatgcc gcgcgcatta ccagcgcacg ccagtgggga
     4501 gaaagccgat ccgcgctgca aaaacgggaa ctggaccgcg ctgccggtcc tgcccttccc
     4561 attccggatg acctgccgtc ccgggagctg gtcggcacaa cgcgccaaat ccatcagctc
     4621 attgaagctt ccggaaatcc ggcacgtttt gaatcctaca cggaaacggt tcccgtggcg
     4681 ggagcttccc tgcgcatggt cgccataccg ggaggaacgt tcctcatggg gagtcccgcg
     4741 gaagagccgc accggaaacc ggacgaaggt ccgcagcata aagtgagcat ctcccccttc
     4801 tggatctcgg aaacggaaat cccctgggaa ctttatacgg ccttcatgga aaacgggcgt
     4861 ccgcgcgcca aggacggcca gcttctggag gaacagccgg atgacgaact gtgggactcc
     4921 gttacgcagc ctaccgcccc ctacaccgcc atgaacctgg gcatgggcca cggctatgaa
     4981 cacggtctgc ccgccatctc catgtcccac cacgccgcca gcaaattctg cgaatggctg
     5041 agcgcccaga ccgggcatta ctaccgcctg cccacggagg cggaatggga atacgcctgc
     5101 cgggccggct cccccggcgc ctattcttac ggaaacgggg aagcctctct ggaccagtac
     5161 gcctggtact ggaacaactc caatgaccgc taccagaaaa caggctctaa aaaaccaaat
     5221 aagtggggac tccgggacat gcacggaaat gtggcggaat gggttttgga ctcttacgtt
     5281 ccggatgcct acggcaaacg gagcggcttg cccgcgaaag accccttggt catcatcccc
     5341 ggcgcccctc acatcgttcg cggcggttcg tgggaagacg acccggacag cctgagaagc
     5401 gctgcgcgcc gcgccagcac ccccgcctgg aaccgtcagg atcctcaaaa ccctaaaagc
     5461 atctggtacc tgacggacgg aggcatgatc gggttccgcg tggtgcgccc catgaacatt
     5521 ccggacatta tgacgatgca ccgcctctgg aatttctcca agggggagcc gtaaagaaca
     5581 acctttcatg accattgcat taagaacgga acaatcctca gaccatgccg aaacggaaca
     5641 tgtcacgaga gaagcgttct ggaactattt cgtccccggc tgccatgaac attacctgct
     5701 ccatatcatg cgcgtcagtc cgtccttcat cccggagctg gatgcagtcg ccatccacgg
     5761 cagccgcatc gtcgggaaac atcgttgatg caacgtccgt catcagggca gacgatggaa
     5821 aagaatatga agtgctgggc atggggccca ttgccgttct tccgaaatac cagcgccggg
     5881 gaataggacg gcggataata ggtatgcggc ggccctccag gtctgtgagc tgcaaagggg
     5941 ttccctatcc ggcctgaaag gccactatgt gaaagctgcc gtgtaccata tggacgaaaa
     6001 gcgcgctgcc gaatttgacg gcattttccg gtaaagaaaa agctttccgg tactgcgtct
     6061 caaaaacgtt tccagcaaat tgccgccatg ccgaaaaaac cggatacggc cccctgcccc
     6121 cggaaattcc gtaccttccg gagggcatga atcccgcata cggataagca attcttcctc
     6181 tctggatata aaaaacaaga gctgttccgc aagaacagct ctcatccgcc gatttttcgc
     6241 catcaggaag ctcaagccct aaggcggcgc atcatcagcg cggccagtcc cagcaggccc
     6301 agggaaaccg tggctggttc cggcaccatt tcccctcgga tttccgtgaa aatcggggat
     6361 aataagctga aagtattggt tccgttggct cccgtaataa cgacagaatc accaggcgct
     6421 ccctcggcgt cataatggcc gcggatgccg ggagcagtca atccgccgct gatcgttacg
     6481 gtatctcctt ccgtgttagc agtaggggcg gctattcccc ccgcagcata taaatacgtt
     6541 ttagacgtat cctgcatcaa gtccatcacg gactggctca cggccaggaa acggtatgtc
     6601 aatgccgcgt caagaagcag gggagaacca tccagggaag aaaaactgaa cgtcagatta
     6661 atccctgctg cagtagttcc cgtattggtg ctccagccga tgaccgaatt gtcggagcca
     6721 ttcagcacca ggaagccgta agtgacatta gcgcccaaat tgttggcggc tccgcgcagc
     6781 gtaaaactgt ccagtctgat ctctccggac agggaggagg gagaagagga atcggaagga
     6841 gccagggaag aagaccccag gccaagataa aacccatgga tggtactatt gtaattatcc
     6901 gtaccgggag tgtaataatt aaaaacggtc gctgcctccg aggaaacagc aaagcttccc
     6961 atcgcgatta aaaatgtcag tgttttcttc atatttatta ttccttttgg atggcaactt
     7021 gtagcgaatt tggaattccc caatcgaatt tggaattccc caatcggatt tggaatccgc
     7081 aagcaattaa aaatattaag agttagtata ttgtatttat aattcattga aaataatgat
     7141 tttttaatat ctctggtcct tttgctaaga tgacgggtca gtctttgtta ttcattggtt
     7201 tcatgattga tttggcctct ttttcattac ttgacggatt ccaaattcgt tattcaagca
     7261 caagtacata cattgaacct tgaatcattt tattaagata ctgaccatga ataaattatt
     7321 atccaacctg attctttcga ccggcatgag cctaagcgct accgcggcta cctctctgtt
     7381 ggatagctcc atcgtgggat attcggactt tgcctcccaa acggcggatt tcggcacccg
     7441 gaaagattcc gtttccatca cgtctgacga tagcaatctg acgttgtccg ggataacctt
     7501 caacggatac ggtgccaaca accgcgacgt tatgtctgtg acgatggttc ttgacctgtc
     7561 caaaatcaac actccggaga cctataccgc tctgtttaac gccaaaaaca gcagtgtaag
     7621 ctggggcgtg ggcctgaaca cggaccggaa actccaggga ttatggaaca acacctcata
     7681 cagcgggccc gtcgttgaca ccccgctggg cacggaaggg tccctgacca tttccgtagt
     7741 caccggagat cttggcaccc gcatctattt tggcgacagc gttacgtact attccaacag
     7801 cggcctgaaa ttcggcaacc agcaaattga tcagattctc atggacgcag gactggctga
     7861 atccatcgaa cagctctaca tccacgactc cctcctttcc caggaacaag ttggtcaact
     7921 gatgagtgaa atcgccagca ttccggaacc cgccacggct tccctgggcc tgctgggact
     7981 ggccgcgctg atgatgcgcc gccgcagggc ataagcctgt accgtccgcc tccctatatt
     8041 caaaggccgg ctcacaaaat cgtgagccgg ccttttcctt atccgttcaa acatctgccg
     8101 aaaaaacaga ggggaaaagc ttccatttgc tgcggcaacc tcacggccag cacttgacgg
     8161 aaaaatggca ttcagtctcc cccggtaggg tcatttcaag agcttccggc cccgccccac
     8221 ttccgtacac gccccttttt cccatgccgg gacagccgga accggagcat gcaaagcccg
     8281 gcttccctca gcatccggaa cagcccatcc tttcagcaat ccatttcccc gcacggtccg
     8341 gatcgctgcg gttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc tgagcttgaa cctttatccc ccgttcccgt ccatgaacct tcaaaaacag
     8461 cagctgctac tgcgcctgtt ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctgggc cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtaccctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc aggagaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgcagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccgcc gcccgcttgg gattcagctt
     8941 actggtggga taaagggtca gcccggccca gtaaccggcc tccttcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccagcacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggcgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagcc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agtttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattctta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtt atccctgtag
     9601 gaaagggctt ccagaatggc ccggacgcgt ccggggccgg atgcggacaa gaggggaaga
     9661 acatccatca gggcatggta gcggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcacc
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa actgataaac agcaacctct ttccccggtt
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatta aggcaacgct
    10321 ctcctcccgc tacatgatct ataccggttt gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct ttatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaacgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctgc gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 gtacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtgcttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagccc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcagccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttccgcgc ccgtgaagcc aatgtctacc gtctggcgga
    11101 agtctcctcc aacattattg accagtgtgt ggcccagggc gttcccttcg gccgtgaata
    11161 cggcggcctg ctggacaacc gctccttcgg cggcgcccag ctcaagcgaa ccttctacgc
    11221 acgcggacag acgggccagc agctcctgct gggtgcctac caggccctgg aaaaggaagt
    11281 ggccaaggga cacattgaaa tgttctcccg ccatgaaatg atggatctgg tgctggtgga
    11341 cggcgaagcc aagggcatcg tcacccgcaa tctggttacc ggcgaaatca aatcctacgc
    11401 aggggatacc gtcctgctct gcacgggcgg ctacggcaac gtgttcttcc tgtccaccaa
    11461 cgcgatgggc tgcaacgtca ctgccgccta caaggcctac aagcgcggtg ccttcttcgc
    11521 caacccctgc ttcacgcaaa tccaccccac ctgcattccg gtcaagggcg actaccagtc
    11581 caaactgacg ctgatgtcgg aatccctccg caacagtggc cgcatctggg tgcccaagtc
    11641 ccgtgaaacc gcagaaaaaa tccgtaaaaa ggaaatcaag ccttccgatg ttcccgaaga
    11701 agaacgggac tactacctgg aacgcaagta tccctccttc ggcaacctgg ctccgcgcga
    11761 catttcctcc cgcgccgcca aggaagcctg cgacgacggc cgcggcgtgg ccgtcaccgg
    11821 caagggcgtc ttcctggatt ttgcggatga aatcaagcgc atgggccgcg aatggattga
    11881 cggccaatac ggcaatctgt ttgacatgta cgaagaaatc acggacgacg acccccatga
    11941 aacgcccatg atgatctacc ccgcctccca ctacaccatg ggcggcctgt gggtggacta
    12001 caacctcatg tccaacgtga aggggctgca cgtcctcggt gaagccaact tctccgacca
    12061 cggcgccaac cgcctgggag cctccgccct gatgcagggc ctgtctgacg gctacttcgt
    12121 cattcccgcc acgttgcccg cttacctgac gaccaccaag cccggcgccg tcaccaccgc
    12181 cgccccggaa ttcaaggctg cggaagacga agtgaaggaa cgcatcaaca agctcctgaa
    12241 tgtgaagggc accaagacgg tggactcctt ccaccgggaa ctgggcctca tcatgtggga
    12301 agactgcggc atggcccgca cggaagaaag cctgacccac gccattgaac gcattcccca
    12361 gctccgcaag gaattctggg aaaacgtgcg cgtaaccggc acggcggacg gcatcaacgc
    12421 ggaactggaa aaagcctgcc gcgtggccga cttcctggaa ttcgcccagc tgctctgcta
    12481 tgacgccctg aaccgccagg aatcctgcgg cgcccacttc cgcgtggaat accagctgcc
    12541 ggacggcgaa gccaagcgca acgacgatga atacgcctat gtagccgcct gggaatacac
    12601 tggcgtggac agcctgcctg ttctccacaa ggaaccgctg accttcgaga acgtgcacct
    12661 tgccatccgc agctacaagt aaagatagcc aatacattaa cactcaaaag aaagattata
    12721 acatggctaa aacactcaat ctcactctca aggtctggcg ccaggaaaac cgggaagcca
    12781 agggccgcat tgagacctat gccgccaagg acattccggt ggacgcctcc ttcctggaaa
    12841 tgctggacat cgtcaatgaa ggcctggtca aggaaggcaa ggaacccatc cattttgacc
    12901 acgactgccg ggaaggcatc tgcggcatgt gctccctgac catcaacggc attccccacg
    12961 ggccggaacg ccaggtgacc acttgccagc ttcacatgcg caagttcaag gacggcgata
    13021 ccgtctggat tgaacccttc cgcgcgaagg ctttcccaat cctgcgggac ctgatggtgg
    13081 accgctccgc cctggaccgc atcatcgccg ccggaggcta tattgacgtg cgtaccggtt
    13141 ccgcgccgaa cgccaacaac atcgccgtgg aaaaagtgaa ggcggacgcc gcctttgacg
    13201 cggccgcctg catcggctgc ggcgcctgcg tggcctcctg taaaaacgct tccgccatgc
    13261 tgttcacctc cgccaagatc gcccatctca atctgctgcc gcagggccag ccggaacgtt
    13321 ccaagcgcgt cctggccatg atgaagcaga tggaagcgga aggctttggc aactgcacga
    13381 accagtatga atgtgaagcc gcctgcccga aaggcatcag cgtggacaac atcgcccgcc
    13441 tcaaccgcga cttcatgcgg gccaacgcca aggaaggcct ctgtttctaa agaagattcc
    13501 ttcttaagac gctctgtaaa aactcccggc ggcatcggct gtcgggagtt ttttcattac
    13561 cagatttcct tgaaccagga ataaaatacc agacagttgc ttcctcatcg tcgcgcagcg
    13621 taaaaaattg ttacaccgga aggcacccag taatccagga gaccgtactt ggcaatgccg
    13681 gatgaaacc
//
