LOCUS       c00052_gnlPro..        15331 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PKDOJPKJ_69.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 14:29:27
            Original ID  :: gnl|Prokka|PKDOJPKJ_69
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15331
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15331
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2040:5331]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2041..5331
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15331
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15331
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             672..857
                     /locus_tag="ctg52_1"
                     /transl_table=11
                     /translation="LKYAFAYKNHNIETIFCGKDELFEELKQFLITQCGLIIVEVSRAD
                     YYTEQEMNQWNDRYTL"
     CDS             complement(897..1247)
                     /locus_tag="ctg52_2"
                     /transl_table=11
                     /translation="MNKMLSGMQGLPPGFPPLPVLPPQSYYPPAPMHTAPYQGGPSFQQ
                     GFPSSGYGQQTPQSTLSFAGQQFVPYPYTTGYYGQSFSDVGGSLGAGAHPGALGGGFSG
                     HAGSFSAPSGFR"
     CDS             2041..3765
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-55, bitscore:
                     180.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTNVQADSLSAECTKTMNGALMLIESLKKENVEMIFGYPGGAVL
                     PIYDKLYQSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADAMI
                     DSLPLVVFTGQVATSVIGSDAFQEADILGITMPITKHSYQVRHPEDLPRVIKEAFHIAT
                     TGRPGPVLIDIPKDVAAFEGEFRYDHEISLPGYQPVKEPNYLQIRKLVEAVSSAKKPVI
                     LAGAGVLHGKASEDLKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYTANMAL
                     YHCDLLISIGARFDDRVTGNLKHFAKSAKVAHIDIDPAEIGKIIETQIPVVGDSKIVLQ
                     ELLKQNGKQGQTEEWKQQLSEWKEEYPLWYTDNREEGLKPQKLIEYIHQFTNGEAIVAT
                     DVGQHQMWAAQFYPFRKADKWVTSGGLGTMGFGLPAAIGAQLADRNATVVAILGDGGFQ
                     MTLQELDVIRQLNLPVKVVILNNECLGMVRQWQEIFYEERYSESKFSAQPDFVKLSEAY
                     GIKGVRISSEEEAEEELKKALSSKEPAVIDVRVAKSEKVFPMIAPGKGLHEMVGVKP"
     CDS             3762..4280
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_4"
                     /sec_met_domain="ALS_ss_C (E-value: 7.2e-31, bitscore:
                     100.2, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETSGVSR
                     ITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSARTEING
                     IIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQQKA
                     SSNKTISIV"
     CDS             4303..5331
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="IlvN (E-value: 2.1e-78, bitscore: 255.5,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4.9e-68, bitscore: 221.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIV
                     GVRQGKSFTQAQEDGHKVFSVREAAAQADIIMVLLPDEQQQKVYESEIKDELTAGKSLV
                     FAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEAKDT
                     ALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPEL
                     AYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDI
                     QNGTFAKEWIVENQVNRPRFNAINASENEHQIEKVGRQLREMMPFVKQGKKKEAVVSVA
                     QN"
     CDS             5318..6874
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_6"
                     /sec_met_domain="HMGL-like (E-value: 1.4e-97, bitscore:
                     320.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAG
                     FPASSRGDFLAVQEIARTIKNCSVTGLARSVKGDIDAAWEALKDGASPRIHIFIATSDI
                     HLKHKLKMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGAS
                     VINLPDTVGYLTPAEYGNIFKYMKEHVPNIGRVKLSAHCHDDLGMAVANSLSAIENGAD
                     QIECAINGIGERAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVP
                     RNKAIVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRL
                     NALGFQFDSEEINKFFTMFKELTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHY
                     GTSQVPTATVSLKNQENEQLIQEAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKG
                     EDALAQVFVRVTVNGKETSGRGIAQDVLEASAKAYLNAVNRQLVLDCNLDGLKRQTAVG
                     S"
     CDS             6895..7992
                     /locus_tag="ctg52_7"
                     /transl_table=11
                     /translation="LKKRIALLPGDGIGPEVAESAADVLKSVAEQFGHEFEFENGLIGG
                     AAIDAHQNPLPEETVALCERSDAILLGAVGGPKWDQNPPELRPEKGLLGIRKKLGLFAN
                     LRPVTVFESLSEASPLKKEYISGVDFVIVRELTGGLYFGEPSRQYVNEAGEKEAVDTLF
                     YKKEEIARVVREAFKMAAGRKGKVTSVDKANVLSSSRLWRETADEIAKEFPDVTLEHML
                     VDNAAMQLIYAPSQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVH
                     GSAPDIAGKGMANPFAAILSAAMLLRTSFGLENEAQAVEKAVAKVLADGSRTRDIARDG
                     QYAGTHDITEKVKAALAGSNTKSIV"
     CDS             8042..9460
                     /locus_tag="ctg52_8"
                     /transl_table=11
                     /translation="MMPRTIIEKIWDRHVVKSGEGKPDLLYIDLHLIHEVTSPQAFEGL
                     RQKGRKVRRPQNTFATMDHNIPTVNRFDIKDEVAKRQVTALERNCEEFGVRLADLHSAD
                     QGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRP
                     KTLEIRVDGTLQKGVTAKDVILSVIGKYGVKFGTGYVIEYTGEVFRNMSMDERMTVCNM
                     SIEAGARAGLIAPDDTTIEYCKNRKYAPKGEEFEKAAAEWKALQTDPGAVYDHSIVLDG
                     SEISPMVTWGVNPGMVLPVDAQIPAPETIDSEGGKKEAIRAYEYMGIAPNQKIEDIKVE
                     HVFIGSCTNSRMTDLRQAADMIKGRKVADSVRAIVVPGSQSVKQQAEEEGLHRVFLEAG
                     FEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGH
                     FVDVRKFYQEKTVV"
     CDS             9476..10075
                     /locus_tag="ctg52_9"
                     /transl_table=11
                     /translation="MEPLKTHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFFD
                     WRYLENGEPDPEFELNRKVYEGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPSFA
                     DIFHQNCFKNGMLPIRMPYDQWKKLAGQYENQSLNMTVDLENQLIHDSEGKEISFEVDP
                     HWKEMLINGYDEISLTLLLEDDIQQFESKRSSWLQA"
     CDS             10193..11197
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MTHDKKKADIIPFPRLKERLVDKGMAAMKDKQYQEALELFSEAVS
                     HGDTESDVHLGMAICFLELGELEEAKQVCEKMLNEGYGHYFTVLQVYMTILIQLKQYEE
                     VKSTIEAVLEENQLPAESAEQFYRLLEFSRKMTDPDQQDEAWEEEYEDILDAEKVLNSP
                     AEQMNLIHSLKDRNIAKYTGLLKTILQDPAAHPLIKTMILTLMAEHDYSKPVHITKFGD
                     SMTAVPSETVQPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLHPFMPKFL
                     NADLWAAALHKVGYEMHGIDIEPEELHMMYEFDSRELEEACTMIKDIEEISYL"
     CDS             11414..12688
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MSVKWEKQEGNEGVLTVEVDADTFKTALDDAFKKVVKQVSIPGFR
                     KGKVPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIDKGESL
                     IFTAKVTVKPEVKLGDYKGLGIEKDDTAVTDEDVQNELKALQERQAELVVKEEGAVENG
                     DTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEEQLTGLEAGAEKDVEVTFPEE
                     YHAEELAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRLEEAKE
                     NEADAKLREELVLKASENAEADVPQAMIDTELDRMLKEFEQRLQMQGMNLELYTQFSGQ
                     DENALKEQMKEDAAKRVKSNLTLEAIAQAENLEVTDEEVEAELTKMAEAYNMPVENIKQ
                     AIGSTDAMKEDLKVRKAIDFLVENR"
     CDS             12960..14222
                     /locus_tag="ctg52_12"
                     /transl_table=11
                     /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTEI
                     VEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKVDD
                     VELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLI
                     QAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQ
                     GGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGSDNKAADLEKEELL
                     SKVLPEDLLRFGLIPEFIGRLPVIASLEQLDETALVEILTKPKNALVKQYKKMLELDDV
                     ELEFEDEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFDLPSRDDIEKCVITGATVAD
                     GEAPRLVLKDGTVVGQDKTSA"
ORIGIN
        1 tgaagaaata tctagaataa cttacacact tttcttgaca agcccgccat tgttgtatac
       61 acaatgactc atcgattctt tcatagctta cttggtgtta caggtattat cgtgggttgc
      121 atcagcatcg caatagggac agcattcttt gttatctctc atgaaaccac tcctttaaat
      181 aaataccttt acgttttata gcagatttaa gtacaactgt tttacctttt aaatagggtt
      241 gttttctact atatgaatgc ttgaattata aagtgtaagc aaatataata gaaagtaagt
      301 caatcggtca aagttcggaa agtgaccgtt atacatgaac gtaacgatag cgatatgtaa
      361 aggatgaagg ccggatagag caacggcctt ctaagccgtc ggtcgggagt tcgaatctct
      421 cctgggacgt ataaaaacct caagccctga caatgggctt gaggtttttt tgtattttat
      481 tttacgaaac aaaagttccg tatttgatga aaattgtaaa gtaattttaa tataaatgaa
      541 acttaatgta atatttacca taataaatat atgtataaag atacttaagg cgcccttgag
      601 tgataaatta tctaatttct atcttacatt ttgtcaataa tcgatagaaa gacagcggga
      661 ggaattagct tttgaagtac gcatttgcat ataaaaatca caatatagaa acgatctttt
      721 gcggaaaaga cgagctgttt gaggaactga agcaattttt aatcactcaa tgcggtttaa
      781 tcattgttga ggtttcaagg gctgattact atacggagca ggaaatgaat caatggaatg
      841 accgttatac tctgtgaata agaaaagaaa ccggccgtgg gaggccggtt tttgtatcat
      901 ctgaatccgc tcggagcgct gaagctcccg gcatggccgc tgaaaccgcc cccgagcgcg
      961 ccgggatgcg ccccggcgcc gaggcttccg ccgacgtcac tgaaggattg gccgtagtac
     1021 ccggttgtat aagggtacgg aacgaattgc tgcccggcga atgacagcgt gctttgcggg
     1081 gtctgctgtc cgtatccgga tgacgggaat ccctgctgaa aagaagggcc gccttgatat
     1141 ggtgctgtat gcatcggggc cggaggataa taagactgcg gcggtaagac cggtaaaggc
     1201 ggaaatccag gaggcaggcc ctgcatgcct gataacatct tattcatgac atcactcatt
     1261 tcttacgaga taagaacagt gtatgcgtat gtctgtagaa agagcctgtt caaccgatcg
     1321 gaatatctga caagcatgcc ggaaggacag agaaaaatcg tgtaataaaa tgtgacatat
     1381 tcgtatatga acggaaaaat ttcatgtaat cttgagagat taataaaaaa atgataaaaa
     1441 cttttaatat ttacagatcc ctttgtacca gtaatgaaag cgtatacaaa gtagattgat
     1501 taatctaaat tgtctaataa ttataaaaat gctgttgaca ctgcctgcaa acgggcgtaa
     1561 tatgagttca aacaaaaata aataaatgat tcacgctaaa aagaaaaatc ataaaacact
     1621 gaaaaaacaa acaagtgaag gttctttttt aataaaagag ctgccataat aaaaagcgca
     1681 gaagaggata agtagctttg ctgaagtttt tcacagagag ccggtaacgc tgagagccgg
     1741 taaaacaaat caaagtgaac tcccctcaga gtgccggtct gaaatgtaaa gagtaggact
     1801 cggccgagtg aacgcaatgt ttactcgtta tcaaaacgga taatcattat ccatgagacg
     1861 gtctgcatat gaccgtaaac aagggtggta ccgcggagag caaagccttt tcgccccttt
     1921 tggctatcgc atgaaatgct tggctgaatg tgggtgggaa ggctttttta tttgcgtcag
     1981 ccggcgctgc gttttatgaa ttggatttta gaagggaaca ttgaaaagga ggaactgaaa
     2041 atgggcacaa atgtacaggc ggattctttg tctgccgaat gtacaaaaac aatgaacggg
     2101 gctctgatgc tgattgaatc attaaagaaa gaaaatgtcg agatgatctt cggctatccg
     2161 gggggagccg tccttccgat ttacgataag ctgtatcagt cgggattggt tcacatcctg
     2221 ccccgccacg agcaaggcgc gattcacgcg gcagaagggt atgcgagagt ctccggaaag
     2281 ccgggggttg tgattgcaac ctcaggaccc ggcgcgacaa atttagttac cggtcttgca
     2341 gatgcgatga ttgattcatt gccgctcgta gtgtttaccg gtcaggtggc cacttcggtc
     2401 atcggcagcg acgctttcca ggaagccgac attttaggaa ttacgatgcc gattacgaaa
     2461 cacagctacc aagtccgcca tccggaagat ctcccccgcg tgattaaaga ggcgttccat
     2521 atcgccacga cgggaagacc gggcccggta ttaattgata taccgaagga tgtcgcagca
     2581 tttgaagggg agttcagata tgatcacgag atcagccttc cgggttatca gccggtaaaa
     2641 gagcctaact atctgcagat ccgaaagctc gtggaagctg tcagcagtgc gaaaaagccg
     2701 gttattttag ccggagcggg tgttttgcac ggtaaagctt cagaagattt aaaaaattat
     2761 gccgaacagc agcaaattcc ggtagcgcac acgcttctcg gtttgggcgg tttcccggca
     2821 gaccatcctc tttttctggg aatggcgggg atgcacggca catacacagc gaatatggcg
     2881 ctttaccact gtgacttgtt gatcagcatc ggagcgcggt tcgatgatcg cgtgaccgga
     2941 aatctgaagc attttgcaaa atcggccaaa gtagcgcata tcgatattga tcctgctgaa
     3001 atcggaaaaa ttatcgaaac gcagattccg gtggtcggcg acagtaaaat cgtccttcag
     3061 gaattattga agcaaaacgg aaaacaggga caaacagagg aatggaaaca gcagctttca
     3121 gaatggaaag aagaatatcc gctttggtat acagacaaca gagaagaggg cttgaaaccc
     3181 caaaagctga ttgagtatat tcaccaattc acaaacggag aggcgattgt ggcgacggat
     3241 gtcggccagc accagatgtg ggcggctcag ttttatcctt tccgaaaggc tgataagtgg
     3301 gtgacctcgg gggggctcgg cacaatgggc ttcggccttc cggcggctat cggagcgcag
     3361 ctggccgatc gtaacgccac ggtcgttgcc atcctcggag acggcggttt tcagatgacc
     3421 cttcaggaat tagatgtcat ccggcagctg aatcttcctg tcaaagtggt tatcttgaac
     3481 aacgaatgtc tgggcatggt cagacagtgg caggaaatct tctatgaaga acgctactct
     3541 gaatccaaat tctcggcgca gcctgacttt gtcaaattgt cagaagccta cggcattaaa
     3601 ggcgtccgga tttcatcgga agaagaggcg gaagaagagc ttaaaaaggc gctttcatca
     3661 aaagaaccgg ccgttattga cgtccgggtc gccaaaagcg agaaagtatt cccgatgatt
     3721 gcgccgggta aaggacttca tgaaatggtg ggggtgaaac cttgaaacgc attatcacat
     3781 taacggtggt caaccgctcg ggagtattaa accggatcac cggcctgttt acaaaaagac
     3841 actataatat cgaaagcatc actgtaggcc acacggaaac aagcggtgtt tcaaggatta
     3901 catttgtcgt ccatgtggaa ggcgaaaatg acgtagagca gctgacaaag cagcttaaca
     3961 aacaaattga cgtcctgaaa gtgacggata ttacaaacca atcaattgta cagcgtgagc
     4021 tggcattaat caaagttgtt tccgcaccgt cggccagaac ggaaatcaat ggaatcattg
     4081 agccgttcag agcttccgtc gttgatgtct caagagacag catcgtcgtt caggttaccg
     4141 gcgaatctaa taaaatcgaa gcgctcatag agcttctcaa accttacgga attaaagaaa
     4201 tcgcgagaac gggcacaacg gcttttgcga ggggaaccca gcagaaggcg tcatccaata
     4261 aaacaatttc aattgtataa cacaaaaaag ggagagatta aaatggtaaa agtatattat
     4321 aacggtgata tcaaagagaa cgtattggca ggtaaaaaag ttgcgattat cggttacggt
     4381 tcacaaggtc acgcacacgc gctgaactta aaagaaagcg gaattgatgt cattgtcggc
     4441 gtcagacaag gcaaatcatt tacacaggcc caagaagacg gtcataaagt cttttcggta
     4501 agagaagcgg ctgcccaggc tgatatcatt atggttcttc ttccggatga acagcagcaa
     4561 aaagtatatg aatctgaaat caaagatgaa ttgacggcgg gcaagtcatt ggtattcgca
     4621 cacggattta acgtccattt ccatcagatc gtgcctcctg ctgatgtgga tgtattcctt
     4681 gtcgccccta aaggacctgg acaccttgtc agaagaacat atgaacaagg cgcgggcgta
     4741 ccggcattgt ttgccatcta ccaggatgta tcaggcgaag cgaaagatac ggctcttgct
     4801 tatgcaaaag gaatcggcgg agcgcgtgcg ggcgttcttg aaacaacatt taaggaagaa
     4861 acggaaacgg atttgttcgg tgagcaggct gttctgtgcg gaggtttaac agcgcttgtc
     4921 aaagcgggtt ttgaaacgct gacagaagcc ggctaccagc ctgaactcgc atacttcgag
     4981 tgtctgcacg aactgaagtt gatcgtagac ttgatgtatg aagaaggatt ggcgggcatg
     5041 agatactcta tctccgatac ggctcaatgg ggagactttg tatcaggacc gcgcgtagtc
     5101 gatgcgaagg taaaagaatc gatgaaacaa gtattaacgg atattcaaaa cggtacattc
     5161 gcaaaagaat ggatcgtgga aaaccaagtg aaccgtcctc gtttcaatgc gatcaatgca
     5221 agtgaaaacg agcatcagat tgaaaaggtc ggcagacagc ttcgtgaaat gatgccgttt
     5281 gtcaaacaag gcaaaaagaa ggaagcggtg gtctccgttg cgcaaaatta atgttttcga
     5341 cacgaccctt cgtgacggtg aacaatcccc cggggtcaac ctcaattccc gggagaaact
     5401 ggcgatagcc aagcagcttg aaagactcgg ggtggacatt attgaagcgg gatttcccgc
     5461 ttcatcccga ggtgattttt tagccgtgca ggaaatcgca agaacgatta aaaattgttc
     5521 ggtaacaggg cttgcccgat ctgtcaaagg tgacatcgac gcagcctggg aagcgctgaa
     5581 agacggggcc agcccgcgga ttcacatctt tatcgccacc tctgacattc atctgaagca
     5641 taagctgaaa atgacgcggg aagaggttaa ggaaaaagcg gttgaaatgg tgaagtatgc
     5701 aaaagaacgc tttccgatcg ttcaatggtc agcagaagac gcatgccgca ccgaacttcc
     5761 gtttctggct gaaatcgtag aaaaagtgat tgatgccggc gcgagcgtca tcaacctgcc
     5821 ggacactgta ggttacctga cgccggctga atacggaaac atctttaaat atatgaagga
     5881 acacgttccg aatatcggcc gggtaaagct ttcagcccat tgccacgatg atctcggaat
     5941 ggcggttgcc aactcacttt cggcaattga gaacggcgca gatcaaattg aatgcgccat
     6001 taacggcata ggagaaagag ccgggaacgc cgcgctagag gaaatcgccg ttgcgcttca
     6061 tgtcagaaat gacgcgcatc aagccgattc atccctcaat cttcatgaat tgaagcggac
     6121 gagtgatctt gtcagcaaac tgacgggcat ggccgttccc cgcaataaag caatcgtcgg
     6181 agataacgct ttcgcacatg agtccggcat tcaccaagac ggtttcctga aagaaaaatc
     6241 aacatatgaa atcatttcac cggaacttgt cggcgtgact gctgatgcgc tcgtactcgg
     6301 aaagcattcc ggacgccatg cgttcaaaga ccgcctgaat gcgcttggat tccagtttga
     6361 tagtgaggaa atcaataaat tttttacgat gtttaaagaa ctgaccgaaa agaaaaaaga
     6421 aatcaccgat gatgacttga tttctcttat tttagaagaa aaagtgacgg acaaaaaaat
     6481 cggctatgaa tttttgtctc tgcaagtgca ttacgggacg tctcaggtgc cgactgcaac
     6541 agtctcttta aaaaatcagg aaaacgaaca gctgattcaa gaggcggcaa cgggggcggg
     6601 cagcgtagaa gccgtttata atacgctcgg gcgctgcatc gataaaaata ttgaactgac
     6661 agactatcgc atccaatcca accggaaagg cgaagacgcg ctggctcaag tttttgtcag
     6721 agtgaccgtg aacggaaaag aaacatcagg gcggggaatc gcgcaggatg ttctggaagc
     6781 ttctgctaaa gcttatctga acgccgtgaa ccggcagttg gtgctggatt gcaatttaga
     6841 cggattaaag agacagactg cggtcggctc gtaatagaaa ggagaacgtt tgatttgaaa
     6901 aaacgcattg ctttgctgcc cggtgacgga atcggaccgg aagtggcgga atcagcggca
     6961 gatgtattga aaagcgttgc cgaacaattc ggacatgaat ttgaatttga aaacgggctg
     7021 atcgggggag cggctattga cgcccatcaa aacccccttc ctgaggagac ggtggctctt
     7081 tgtgaaagat ctgacgccat cctgctcggg gcagtcggcg ggccgaaatg ggaccaaaat
     7141 cctccagagc tcagaccgga aaaaggcctg cttggcatca gaaaaaaact cggcctgttt
     7201 gccaatctgc gtcccgtgac cgtatttgaa agcctgtctg aagcgtctcc gctgaaaaaa
     7261 gaatatatca gcggcgtcga ctttgtaatc gtcagggaac tgacgggcgg cctctacttc
     7321 ggagaaccga gcagacagta tgtcaatgaa gcgggagaaa aggaagcggt cgataccctt
     7381 ttttataaga aagaagaaat cgcacgcgtt gtcagagaag cctttaagat ggctgccggc
     7441 agaaaaggaa aagtgacgtc cgtcgataag gcgaatgtgc tttcttcaag caggctatgg
     7501 cgggaaacag cggatgaaat cgcaaaagaa tttcctgatg tgacgcttga acatatgctt
     7561 gtcgataatg ccgcgatgca gctcatctat gctccgagcc agtttgacgt catcgtaact
     7621 gagaatatgt tcggcgatat tttaagcgat gaagcctcca tgctgacagg ctcgctcggc
     7681 atgctgccgt cagccagttt atcaagttca ggtcttcact tgtttgaacc cgtgcatgga
     7741 tctgcgcctg acatcgccgg taaagggatg gccaatccgt ttgcggcgat tttatcagcg
     7801 gcgatgcttt tgagaacatc tttcggactt gaaaacgaag ctcaggcggt ggaaaaggcg
     7861 gtcgcaaagg tgcttgcaga cggcagccgt acacgtgata tcgcccggga cggccaatat
     7921 gccggaacgc atgacattac tgaaaaagta aaagccgcat tagccggctc gaatacaaaa
     7981 tctatagtgt gacgctttaa agaaagcggt cttagttcat aggtagaggg aggaaacaaa
     8041 gatgatgcct cgaacaatca tcgaaaagat ttgggatcgg catgttgtaa aaagcggtga
     8101 aggaaaaccc gaccttctct atattgatct gcacctaatt catgaggtga cgtctcctca
     8161 ggcgtttgaa gggttaaggc agaaggggag aaaggtcaga cggccgcaga acacattcgc
     8221 gacgatggac cacaatattc cgaccgtcaa ccgttttgac attaaagatg aagtcgcaaa
     8281 gcgccaagta accgcgcttg aacggaattg tgaggagttc ggcgtccgtc ttgcggatct
     8341 tcacagcgca gaccagggaa tcgttcacgt ggtcgggcct gagcttggtc tgacacttcc
     8401 gggaaaaacg atcgtttgcg gagacagcca tacatcgact cacggcgcgt tcggagcgct
     8461 tgccttcggt atcggcacaa gtgaggtgga acatgttctt tccacacaga cattatggca
     8521 gcaacggccg aaaacgcttg aaatccgcgt tgacggaacg ctccaaaaag gagtgaccgc
     8581 gaaggatgtc atcttgtcgg tcatcggaaa atacggggtg aaattcggta ccggatatgt
     8641 cattgaatac accggggaag tattcagaaa catgtctatg gacgaacgca tgacggtctg
     8701 caatatgtca atagaagcgg gagcacgggc gggactgatc gctccagatg acacgacgat
     8761 tgaatattgt aaaaaccgta aatacgcgcc aaaaggcgag gaatttgaaa aagccgccgc
     8821 agaatggaaa gcgttacaaa ccgatccggg cgccgtatac gatcattcca tcgtgttaga
     8881 cggcagcgag atttctccaa tggtaacatg gggcgtcaat cccggcatgg ttcttccggt
     8941 cgatgcccaa ataccggcgc cggaaaccat tgattctgaa ggcggtaaaa aagaagccat
     9001 ccgcgcgtac gaatacatgg gaatcgcacc gaatcaaaaa attgaagata ttaaagtcga
     9061 gcatgtgttt atcggctcct gtacaaattc gcggatgacc gatcttcgcc aggctgcgga
     9121 tatgatcaaa ggccgaaaag tcgctgacag cgtcagggcc attgtggtgc cgggttctca
     9181 aagcgtgaaa cagcaggccg aggaagaagg gctgcaccgc gtgtttctcg aggccggatt
     9241 tgaatggaga gaatcaggct gcagcatgtg cctcagtatg aacaatgatg tcgtgcctga
     9301 aggggaacga tgcgcttcca cctccaaccg caacttcgaa ggcagacagg gaaaaggcgc
     9361 gagaacacac cttgtcagtc cggcgatggc ggcaatggca gccattcacg ggcatttcgt
     9421 cgatgtaaga aagttttatc aagaaaaaac agttgtgtaa ggagtgcgcg aaaagatgga
     9481 acctttaaaa acgcatacgg gaaaagcggc cgtcttaaac cggatcaacg tcgatacgga
     9541 ccagattatt ccgaaacagt ttttgaaaag aattgaaaga accggatacg gcagattcgc
     9601 gttttttgat tggagatacc ttgagaacgg tgagcctgat cctgaatttg aattaaaccg
     9661 caaagtctat gaaggcgcgt ccatattaat tgccggagag aatttcggct gcggatcatc
     9721 ccgtgagcac gctccttggg cgctggatga ttacggcttc aaaatcatca ttgctccgtc
     9781 atttgccgat atttttcatc aaaactgttt taaaaacggt atgcttccca tccgtatgcc
     9841 gtatgatcag tggaaaaaac tcgccggtca atatgaaaat cagtctctta acatgacggt
     9901 tgatttggaa aaccagctca ttcacgacag tgaaggaaaa gagatttcat ttgaagtcga
     9961 tccgcactgg aaggaaatgc tgattaacgg ttatgatgaa atttcattaa cgcttctgct
    10021 ggaggacgac attcagcagt ttgaatcgaa aagaagttca tggcttcaag cctgaaaaaa
    10081 gccgcccggc atctgtccgg cggctttttt taccgtgcgc accatccttt cttgtgtttc
    10141 ctgacgcgtg ttgatacact tgaacaaaat agcgcctgaa aggaaataaa gtatgacgca
    10201 tgacaagaaa aaagctgata tcattccttt cccccgtctg aaagaacgct tggttgataa
    10261 agggatggcc gccatgaagg ataaacagta tcaggaggcc ctcgaactgt tttcagaggc
    10321 ggtaagccac ggtgataccg agtccgacgt acatttaggc atggcgattt gttttctgga
    10381 actcggggaa ttggaagaag caaaacaagt ttgcgagaaa atgctgaatg aagggtacgg
    10441 ccattatttt accgtactgc aggtgtatat gaccatttta attcagctga aacaatatga
    10501 agaagtcaaa agcacaattg aagctgtgct ggaagaaaac cagctgcccg cagaaagtgc
    10561 ggagcaattc taccggctgc tcgaattcag ccgcaaaatg accgatcccg accagcagga
    10621 tgaagcatgg gaggaggaat acgaggacat tcttgatgcg gaaaaagtgc tgaacagccc
    10681 cgctgaacaa atgaatctga ttcattctct taaagaccgc aatattgcaa aatacacggg
    10741 tctcttaaaa acaattcttc aagatccggc cgcgcatccg cttatcaaga cgatgatttt
    10801 gacgctgatg gcggagcatg actacagcaa gccggtccat attacaaaat tcggcgattc
    10861 aatgaccgcg gttccgagtg aaacggttca gcctgatgcg gctccgattt tgcatcgcgt
    10921 tctccgggtg cttgatgaaa cgctcggcaa tgaaaaccct acattatacg ctgccgtcga
    10981 ggagctgtgg agaaggcatc tgtatgtcct gcaccctttt atgccgaagt ttttgaacgc
    11041 agatttatgg gcggcggcgc ttcataaggt cggttacgag atgcacggca ttgacattga
    11101 gccggaggaa cttcatatga tgtacgagtt tgacagccgc gaactcgaag aagcctgcac
    11161 gatgattaag gatattgaag aaatttctta tttgtaaatc acgccatata gttgaaagcg
    11221 gtaggcgtta tgttataata tagtggttgt atttatgtat agcggtttaa ctgaaatgag
    11281 aattacggtt ggacaggctg ccagttcatt acataatgat tctgattcaa agcggttttt
    11341 tctttgacaa agccgcggat tgctttagaa tggaagaccg acacaacctg aatagatttt
    11401 tggagggaaa cacatgtctg taaaatggga aaaacaagaa ggcaacgaag gcgtattaac
    11461 ggttgaggtt gatgcggata cgttcaaaac agctcttgat gatgcattta aaaaagtagt
    11521 aaaacaggtt tctattcctg gattccgcaa agggaaagtt ccccgcggtt tattcgaaca
    11581 gcgtttcggc gttgaagctc tttaccagga tgctttagat attttacttc ctgtagaata
    11641 ccctaaagcg gttgaagaag ccggcatcga acctgtagac cgccctgaaa tcgatgttga
    11701 aaaaatcgat aaaggcgaaa gcttgatttt cactgcaaaa gtgactgtaa aaccggaagt
    11761 gaaacttggc gactacaaag gcttaggaat cgaaaaagat gacactgccg ttactgacga
    11821 agatgtacaa aacgaactta aagctcttca agagcgtcag gctgagcttg tcgtgaaaga
    11881 agaaggcgct gttgaaaacg gcgatacagt cgttcttgac ttcgaaggtt tcgttgacgg
    11941 cgaagcgttt gaaggcggaa aagctgagaa ctactcactt gaagtaggat caggttcatt
    12001 catcccgggc ttcgaagagc agttaacagg ccttgaagca ggcgctgaaa aggatgttga
    12061 agtaacattc cctgaagagt accacgctga agagcttgcc ggaaaaccag ctgttttcaa
    12121 agtgaaaatt catgaaatca aagcgaaaga gcttcctgag cttgacgacg aattcgcaaa
    12181 agacattgac gaagaagttg aaacgcttgc tgaattaact gagaaaacaa aaaaacgcct
    12241 tgaagaagca aaagaaaacg aagctgacgc taaattgcgt gaagagcttg ttctgaaagc
    12301 atctgaaaac gctgaagctg atgttcctca agcgatgatc gacactgagc ttgaccgcat
    12361 gctgaaagaa ttcgaacagc gtctgcaaat gcaaggcatg aaccttgagc tttacactca
    12421 attctcaggc caagatgaaa acgcgttaaa agagcaaatg aaagaagatg ccgcaaaacg
    12481 cgtaaaatca aacctgactc ttgaagcgat cgctcaagct gaaaaccttg aagtaacgga
    12541 cgaagaagtt gaagctgagc tgactaaaat ggctgaagct tacaacatgc cggttgaaaa
    12601 cattaagcag gcaatcggtt caactgacgc gatgaaagaa gatttaaaag ttcgaaaagc
    12661 aattgatttt cttgtagaaa accgttaata tggttcataa taatagacat aataaaacag
    12721 ggcgcgatta attcgtgcct tgttttgtac aattatgata taactctttt tcttggggca
    12781 agatagtcat tgccgggctg tttttcgtca tacatataga atgtgcaagt gcgaaacaca
    12841 ttgttaccgt cttactggaa agtatggtaa aatgcaatac atactcgatc gtagcaagaa
    12901 ccgttttctt ttgcccttca ggtaaaagaa aaagtgagac aagattaagg ggtgaaagaa
    12961 tgtttaaatt caacgaggaa aaaggacaat tgaaatgctc gttctgcgga aaaacgcaag
    13021 atcaggttcg taagctggtt gcaggaccgg gtgtatatat atgcgacgaa tgtattgagc
    13081 tctgtacaga aatcgtagag gaagagcttg gtacggaaga agaagtcgaa tttaaagacg
    13141 ttccgaagcc gcaggaaatc cgtgagattc tgaatgaata tgtcatcgga caggatcagg
    13201 cgaagaaatc acttgcggtt gcggtataca accattacaa acgcatcaat tccaacagta
    13261 aagtggatga tgttgagctt tctaaaagta atatttcttt aatcggaccg actggaagcg
    13321 ggaaaacact tcttgcccag acgcttgcgc gtattctgaa cgtgccgttt gcgatcgcgg
    13381 acgctacatc tctgactgaa gccggatatg tcggtgagga cgtagaaaac atcctcctca
    13441 agctgattca ggcagcagac tatgatgtgg aaaaagcaga aaaaggcatt atttatatcg
    13501 atgaaatcga taaagtagcg cgaaaatctg aaaatccgtc cattacacgc gacgtatcag
    13561 gcgaaggcgt tcagcaggcg ctgctgaaaa ttcttgaagg aacggttgca agcgtgccgc
    13621 ctcaaggagg acgcaaacat cctcatcagg aattcatcca gatcgatacg acgaacatct
    13681 tgttcatttg cggcggtgca tttgacggca tcgaacaaat catcaaacgc cgtctcggac
    13741 aaaaagtcat cggcttcggc tctgataata aagcggcaga ccttgaaaaa gaagaactgc
    13801 tttctaaagt tcttccggaa gacttgctcc gtttcggtct gattcctgaa ttcatcggcc
    13861 gtcttcctgt cattgcaagc cttgagcagc ttgacgaaac ggcactggtt gaaattctga
    13921 ctaaaccgaa aaacgcactc gtcaaacaat acaagaaaat gttagaactt gatgatgtcg
    13981 agcttgaatt tgaagacgag gcattatctg aaattgcgaa aaaagcgatc gagcgtaaaa
    14041 caggcgcacg cggcctgcgt tctatcattg aaggcatcat gcttgacgtc atgtttgatc
    14101 tgccgtcccg cgatgatatt gaaaaatgtg tcattaccgg agcgacagtc gcagacggtg
    14161 aagcaccgcg tcttgtatta aaagacggca cagttgtcgg ccaagataaa acatcagcat
    14221 aacatgacaa aacctcctga cccgaattga tcaggaggtt ttttttcttg tcctgaccct
    14281 tctgaaaatg tttattccgg gctttgctgg gagatactag cggacagagg aatgaattgg
    14341 atacataaat cgttttttca ggagggacca gcatgagttg gacagggatc gcattatttg
    14401 tacagctgtt tttcggaata gtcatcggat tatatttttg gaatctgctc aaaaaccagc
    14461 gtacacaaaa agtgacgata gataaagaat caaaaaaaga aatggaacag ctgcgcaaaa
    14521 tgcgcgccat cagtttatca gaacctttat cagaaaaggt gcggccgaaa agctttcagg
    14581 acattgtcgg ccaggaagac ggaattaaag cgttaaaagc agcgctttgc ggaccgaacc
    14641 cgcagcacgt cattatttac ggtcctccgg gagtcggtaa aacggctgcg gcgcggctgg
    14701 tattggaaga agcgaaaaaa cataaacagt caccgtttca aaagcaggct gtttttgttg
    14761 aacttgatgc gacgaccgcg cggtttgatg aacgggggat tgccgatccg cttatcggtt
    14821 cagtgcatga tcccatttat cagggagcgg gtgcgatggg ccaagcaggc attccgcagc
    14881 cgaaacaggg ggctgtgacc catgctcacg gcggggtatt gtttattgat gaaatcggcg
    14941 agcttcaccc gattcagatg aataaaatgc tgaaggtgct tgaagatcga aaagtatttt
    15001 tagacagtgc gtattacagt gaagaaaata cgcaaatacc gaatcacatt catgatattt
    15061 ttcaaaatgg gcttccggca gatttccgtt tgatcggagc gacaacgaga atgccgaatg
    15121 aaattccgcc ggccatccgt tcgcgctgtc ttgaagtatt tttccgcgag ttggaaaagg
    15181 atgaacttaa aatcgttgcg aaaaaagcag ccgacaaaat tcagaaagag atttctgacg
    15241 aagctctcag tgtgctgacc gcatatacga gaaacggacg tgaagccgtc aatatgatcc
    15301 agatcgccgc cggcatggcg gtgactgagg a
//
