LOCUS       c00008_gnlPro..        14733 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NFNJMHEK_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 11:11:44
            Original ID  :: gnl|Prokka|NFNJMHEK_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14733
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14733
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1243:4733]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1244..4733
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14733
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14733
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(3..581)
                     /locus_tag="ctg8_1"
                     /transl_table=11
                     /translation="VRLSGQPDPDPLPFEAIRIHEERKVGPPSTSADGHSAHGTFTIPE
                     GAEGKKLYGTCSLFLGVDDWGILEVKDSGGNVVAQVDLKENPQTAGEQGGHKYHTGTGG
                     AQLPSGTYSWEVSQTNIDYNPASGNTSICNYSIDVVPTEPGGRKEPEPCPCEGDTCDNS
                     GGTPPSPPQARSCPEAGMESGALGNYSSAG"
     CDS             complement(1244..2011)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_2"
                     /sec_met_domain="Fer2_3 (E-value: 2.2e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 7.5e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.3e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(2052..4010)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.2e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(4032..4733)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_4"
                     /sec_met_domain="SucD_FumR (E-value: 2.6e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             4934..5206
                     /locus_tag="ctg8_5"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             5239..6024
                     /locus_tag="ctg8_6"
                     /transl_table=11
                     /translation="MVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSADGFRDYFVQLT
                     ECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLGIGEIGLNRNT
                     SHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLDPCRVLVDHCE
                     EHTFPLVKEAGYWAGLTLYPTSKLNPKRAGDILELYGMDRVWANSAADWGDSDPLALTA
                     LACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(6058..6291)
                     /locus_tag="ctg8_7"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(6723..7430)
                     /locus_tag="ctg8_8"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATSLLDSSIVGYSDFASQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLTKINTPDAYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYNGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             complement(7461..7550)
                     /locus_tag="ctg8_9"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKHKYIH"
     CDS             7755..8465
                     /locus_tag="ctg8_10"
                     /transl_table=11
                     /translation="MGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGLGSSSLAPSDS
                     SSPSSLSGEIRLDSFTLRGAANGLGANVTYGFLVLNGSDNSVIGWSTNTGTTAAGINLT
                     FSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAPTANTEGDTVT
                     ISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEMVPEPATVSLG
                     LLGLAALMMRRRRA"
     CDS             complement(8683..8817)
                     /locus_tag="ctg8_11"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGRYVKATVYHMDEKRAAEFDGIFR"
     CDS             complement(8929..9102)
                     /locus_tag="ctg8_12"
                     /transl_table=11
                     /translation="MIIALRTEHVTREALWNYFVPGCNEHYLLHIMRVSPSFIPELDTV
                     AVHGSRIVGKHR"
     CDS             complement(9116..10321)
                     /locus_tag="ctg8_13"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSVLLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMVAIPGGTFLMGSTAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDVMTMHRLWNFSKG
                     EP"
     CDS             complement(10345..11118)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_14"
                     /sec_met_domain="adh_short_C2 (E-value: 2.7e-75, bitscore:
                     244.9, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILI
                     SRSPSSCGGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGIT
                     RDSLMLRMKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQA
                     NYAASKAGLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKE
                     QGSVEDIAALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(11218..11736)
                     /locus_tag="ctg8_15"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LMEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLAEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             complement(11799..13274)
                     /locus_tag="ctg8_16"
                     /transl_table=11
                     /translation="MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITP
                     EMEQAIHTIRTAENANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRP
                     AREMSGGWIMRAYLAKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHD
                     RDFMDELVESVYDIDNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFID
                     RFRSINSKAGQVQSRIKQLEKMKIIQKPVACRKVFKFNFPQPPRSTQKVIELEKVCQSY
                     GDRRVYENLDLLVERGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFS
                     QARTENLNPENTVLEEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLS
                     LVKFLVDPPNLLLMDEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLH
                     VNRGTITAYAGGYDYYLEKSGILDDEKGGITAE"
     CDS             13339..13485
                     /locus_tag="ctg8_17"
                     /transl_table=11
                     /translation="MVISVSLNKVRPAWDFVRFLIVSMVKRGCILPGWKGEGKSRQGGG
                     RHF"
     CDS             13649..14239
                     /locus_tag="ctg8_18"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQAALPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
ORIGIN
        1 ccccccgccg agctgtagtt tcccagggcg ccgctttcca tgcccgcctc agggcacgac
       61 cgggcctgcg gcggggaggg cggcgttccg ccgctgttgt cgcacgtgtc tccctcgcag
      121 ggacacggtt cgggttcttt cctgcccccc ggttccgtcg gcaccacgtc gatgctgtag
      181 ttgcagatgg aggtgttgcc gcttgccgga ttgtagtcga tgttggtctg gctgacttcc
      241 cagctgtagg tgccggaggg gagctgcgcc ccgccagtcc ccgtgtggta tttgtgcccg
      301 ccctgttcgc ccgccgtctg cgggttttct ttcagatcca cctgcgccac cacgttgccg
      361 ccggagtcct tcacctccag gattccccag tcgtccaccc caaggaagag cgagcaggtg
      421 ccgtagagtt ttttgccctc cgctccttcc gggatggtga atgtcccgtg cgcgctgtgc
      481 ccgtccgccg acgtgctcgg cggccccact ttcctttcct catggatccg gatcgcttca
      541 aacggcagcg gatcgggatc cggctggccg gataagcgca cgcggcgagt agagccggat
      601 tggctggcac cggaaccaaa gtaccatttc cggtaagcgg gaacggcaga acgatgggcg
      661 gaggaggaac gatgaggcgg attcatcagg tattcaagag ttgggagtaa tgaatgaagc
      721 gaggggtggc cgccctttcc tgatcgtttt atcaatagta tgatccgaag tcggtgtcga
      781 tagaatttta tttgtatgtt tttgattttt tataaaagat ggtcattatt ttacacgaaa
      841 agataatatt ataattctta cgttcagtgc attcccttaa tagacatcaa tgttgtctgt
      901 ttgttagaaa atgtttccct ctcatgctga gcccttgaca ggatgccatc ccttccgggc
      961 atcagtctaa ttcctgtaat caatgtttct ttctctcgaa gaaagatggg ggccgtcgct
     1021 gtcggaaggg ggcttgctta ggtttcgtcc ggcatttcca agtacagtct cctggattac
     1081 tgggaacctt ccagtgtaac atttattttt tacgctgcgc gacgatgagg aagcaactgt
     1141 ctgatatttt attcctggtt caaggaaacc tgataatgaa aaaaactccc gacagccgat
     1201 gccgccggga gtttttacag agcgtcttaa gaaggaatct tctttagaaa cagagacctt
     1261 ccttggcgtt ggctcgcatg aagtcgcggt tgaggcgggc gatgttgtcc acgctgatgc
     1321 ctttcgggca agcagcttca cattcatact ggttcgtgca gttgccgaag ccttccgctt
     1381 ccatttgctt catcatggcc aggacgcgct tggaacgttc cggctggccc tgcggcagca
     1441 gattgagatg ggcgatcttg gcggaggtga acagcatggc ggaggcgttt ttacaggagg
     1501 ccacgcaggc gccgcagccg atgcaggcgg ccgcgtcaaa ggcggcgtcc gccttcactt
     1561 tttccacggc gatgttgttg gcgttcggcg cggaaccggt acgcacgtca atatagcctc
     1621 cggcggcgat gatgcggtcc agggcggagc ggtccaccat caggtcccgc aggattggga
     1681 aagccttcgc gcggaagggt tcaatccaga cggtatcgcc gtccttgaac ttgcgcatgt
     1741 gaagctggca agtggtcacc tggcgttccg gcccgtgggg aatgccgttg atggtcaggg
     1801 agcacatgcc gcagatgcct tcccggcagt cgtggtcaaa atggatgggt tccttgcctt
     1861 ccttgaccag gccttcattg acgatgtcca gcatttccag gaaggaggcg tccaccggaa
     1921 tgtccttggc ggcataggtc tcaatgcggc ccttggcttc ccggttttcc tggcgccaga
     1981 ccttgagagt gagattgagt gttttagcca tgttataatc tttcttttga gtgttaatgt
     2041 attggctatc tttacttgta gctgcggatg gcaaggtgca cgttctcgaa ggtcagcggt
     2101 tccttgtgga gaacaggcag gctgtccacg ccagtgtatt cccaggcggc tacataggcg
     2161 tattcatcgt cgttgcgctt ggcttcgccg tccggcagct ggtattccac gcggaagtgg
     2221 gcgccgcagg attcctggcg gttcagggcg tcatagcaga gcagctgggc gaattccagg
     2281 aagtcggcca cgcggcaggc tttttccagt tccgcgttga tgccgtccgc cgtgccggtt
     2341 acgcgcacgt tttcccagaa ttccttgcgg agctggggaa tgcgttcaat ggcgtgggtc
     2401 aggctttctt ccgtgcgggc catgccgcag tcttcccaca tgatgaggcc cagttcccgg
     2461 tggaaggagt ccaccgtctt ggtgcccttc acattcagga gcttgttgat gcgttccttc
     2521 acttcgtctt ccgcagcctt gaattccggg gcggcggtgg tgacggcacc gggcttggtg
     2581 gtcgtcaggt aagcgggcag cgtggcggga atgacgaagt agccgtcaga caggccctgc
     2641 atcagggcgg aggctcccag gcggttggcg ccgtggtcgg agaagttggc ttcaccgagg
     2701 acgtgcaacc ccttcacgtt ggacatgagg ttgtagtcca cccacaggcc gcccatggtg
     2761 tagtgggagg cggggtagat catcatgggc gtttcatggg ggtcgtcgtc cgtgatttct
     2821 tcgtacatgt caaacagatt gccgtattgg ccgtcaatcc attcgcggcc catgcgcttg
     2881 atttcatccg caaaatccag gaagacgccc ttgccggtga cggccacgcc gcggccgtcg
     2941 tcgcaggctt ccttggcggc gcgggaggaa atgtcgcgcg gagccaggtt gccgaaggag
     3001 ggatacttgc gttccaggta gtagtcccgt tcttcttcgg gaacatcgga aggcttgatt
     3061 tccttcttac ggattttttc tgcggtttca cgggacttgg gcacccagat gcggccgctg
     3121 ttgcggaggg attccgacat cagcgtcagt ttggactggt agtcgccttt gaccggaatg
     3181 caggtggggt ggatttgcgt gaagcagggg ttggcgaaga aggcaccacg cttgtaggct
     3241 ttgtaggcgg cagtgacgtt gcaacccatc gcgttggtgg acaggaagaa cacgttgccg
     3301 tagccgcccg tgcagagcag gacggtatcc cctgcgtagg atttgatttc gccggtaacc
     3361 agattgcggg tgacgatgcc cttggcttcg ccgtccacca gcaccagatc catcatttca
     3421 tggcgggaga acatttcaat gtgtcccttg gccacttcct tttccagggc ctggtaggca
     3481 cccagcagga gctgctggcc cgtctgtccg cgtgcgtaga aggttcgctt gagctgggcg
     3541 ccgccgaagg agcggttgtc cagcaggccg ccgtattcac ggccgaaggg aacgccctgg
     3601 gccacacact ggtcaatgat gttggaggag acttccgcca gacggtagac attggcttca
     3661 cgggcgcgga agtcgccgcc tttaacggtg tcgtaaaaca ggcggtaaac ggagtcgccg
     3721 tcgttctggt agttcttggc cgcgttaatg ccgccctggg ccgcaatgga gtgggcgcgg
     3781 cgggggctgt cctggtagca gaagcatttg acgttgtagc caagttcggc aagcgtggcg
     3841 gcagcggagg cgccagccag gccggaacct accacaagta ccgtgtactt gcgcttgttg
     3901 ttcggattga tcagtttgga ctcaagtttg tatttggacc atttgtcctg aatagggccg
     3961 gagggaattt tggcatccgg catccagtcg cttacgggaa aattaatcat gactttgaga
     4021 ggagttgatg gttatttgat gatacccaga agaaccgaga ccggcacgga gatgaagccc
     4081 aggcagataa tcgcgccgta ggcgatggcg ataaagttgt agaagggccg gattttgcgg
     4141 gaatcgacgc ccacagtctg gaagatggac tgtaccccgt ggcgcagatg gctgaacagc
     4201 atcagaacgg ccaggatgta gaaggcggag caccatacgt tggagaatcc ggtcacgatc
     4261 atcttgtaca cgtcaaaggt ttccaccgta ccgtcggaaa tgaaggtggt gaactgggcg
     4321 gggtcgtatc ccacgcgcag ggtgtactgg tacaggtggt agatcaggaa caccaggacg
     4381 gtcaaaccgg tatagatcat gtagcgggag gagagcgttg ccttaatggt gttcttgaac
     4441 acgtagggtt cgcgggccgc atggttttcc agcttcagct ggatggtcag ccagacgtgg
     4501 atgatgaaga tcaccgcaag ccccgcgcgg attccccaga gggctgcttc cggcatggag
     4561 tgcaggccgt gggcgtaggt gttgatccat tcagggcctc cgaagatgag aaggttgcct
     4621 gccaggtgtc ccgcaaggaa caagaccaaa cataaccccg tcagagccac aatgattttg
     4681 cggccgatgg aggatgtcac gaatgtacat atggttttta ctagtgcatt cataggcgct
     4741 ctaatgaaat aaatgcgtct tcacaggatg cccggttcaa gcccggatgg caagcctctt
     4801 cttgaatttc cggcgctttt cggatttttg aaaaaccggg gaaagaggtt gctgtttatc
     4861 agtttggaat ggttatcatt ttgttgcctg ttccggcttg acgaggcttt ccgcataggc
     4921 gtatcgtctg tgcatgaaaa gaagtaaaaa ggaggtgctg gacgcggatt tcgcagcggc
     4981 gcgcgccggc gttctggatg tggccgcatt tctggaccgg gtggaccgcg gggaagggga
     5041 ggcggatttc cgctaccatg ccctgatgga tgttcttccc ctcttgtccg catccggccc
     5101 cggacgcgtc cgggccattc tggaagccct ttcctacagg gatgacaccg tgccggaaac
     5161 cgccgcagcc aaagcggcct gcggagcccc gaacctcagc aaataagaat gatggctttc
     5221 atagaacctc atatacatat ggtgtgccgc accacggacg aataccgggc catggcgcag
     5281 gccggctgcc tggcggtagg ggaaccggcg ttctgggccg gttacgaccg ttcgtccgcg
     5341 gacggtttcc gggattattt cgtacagctt acggaatgcg aacccgccag ggcggccaag
     5401 ttcggcatgg accattacac atggctgtgc atcaatccca aggaggcgca ggacgtggct
     5461 ttcgcgcggg atgtgatgaa actgattccg gagttcattg accggcccaa tgtcctcggc
     5521 atcggggaaa tagggctgaa ccggaatact tcccatgaaa tgactatttt tgaagagcat
     5581 ctggatctgg cggtgcgcct caaccagctt gtgctgattc acactcccca tctggaagac
     5641 aagcttaagg ggaccgtaat gattctttcc gccctgaaaa accgtccgga tctggaccct
     5701 tgccgcgtgc tggtggatca ctgtgaggaa cataccttcc cgctggtgaa ggaggccggt
     5761 tactgggccg ggctgaccct ttatcccacc agtaagctga atcccaagcg ggcgggggat
     5821 attctggaat tgtacggaat ggaccgtgtc tgggccaatt ccgcggcgga ctggggggat
     5881 tccgatcccc tggcgctgac ggccctggcc tgcgagctgc gcaggcgcgg tttttcccgg
     5941 caggaaacgg aacgtcttct cctggaaaat ccggagacat tcatgggaca gtccccgaag
     6001 ttccggaaag tgtcgtcccg ctaattccgc ccgaggcgcg gcggagggta cggccctcta
     6061 gtccccgtcc gggaaaaaga cggtgaggac ggcgcccagg atgaccgccg cgtcatccag
     6121 aaggcccagc ctgccgattc cgtcaaacag gaattcgtcg ggagtcagga tgtaggcgcc
     6181 ggcggcggcc agaaggcata tattccgttt gttgaaaaaa cgcggttctc cttttctgct
     6241 tttgaaatac cggaacaggc gcagtagcag ctgctgtttt tgaaggttca tggacgggaa
     6301 cgggggataa aggttcaagc tcggccattt tcccactcct tttccctgtt tcggggaagg
     6361 agtctgttgc cgacggacgg aaaccgcagc gatccggacc gtgcggggaa atggattgct
     6421 gaaaggatgg gctgttccgg atgctgaggg aagccgggct ttgcatgctc cggttccggc
     6481 tgtcccggca tgggaaaaag gggcgtgtac ggaagtgggg cggggccgga agctcttgaa
     6541 atgaccctcc cgggggagcc tgaatgccat ttccccgtca agtgctggcc gtgagggtac
     6601 cgcagcaaat ggaagcttct tcccccctgt tttttccggc agatgtttga acggataagg
     6661 aaaaggccgg ctcacgattt tgtgagccgg cctttgaata tagggaggcg gacggtacag
     6721 gcttatgccc tgcggcggcg catcatcagc gcggccagtc ccagcaggcc cagggaagcc
     6781 gtggcgggtt ccgggatgct ggcgatttca ctcatcagtt gaccaacttg ttcctgggaa
     6841 aggagggagt cgtggatgta gagctgttcg atggattcag ccagtcctgc gtccatgaga
     6901 atctgatcaa tttgctggtt gccgaatttc aggccgctgt tggaatagta cgtagcgctg
     6961 tctccaaaat agatgcgggt gccaagatct ccggtgacta cggaaatggt cagggaacct
     7021 tccgtgccca gcggggtgtc aacgacgggc ccgttgtatg aggtgttgtt ccataatccc
     7081 tggagtttcc ggtccgtgtt caggcccacg ccccagctta cactgctgtt tttggcgtta
     7141 aacagagcgg tataggcgtc cggagtgttg attttggtca ggtcaagaac catcgtcaca
     7201 gacataacgt cgcggttgtt ggcaccgtat ccgttgaagg ttatcccgga taacgtcaga
     7261 ttgctgtcgt cagacgtgat ggaaacggaa tctttcaggg tgccgaaatc cgccgtttgg
     7321 gaggcaaagt ccgaatatcc cacgatggag ctatccagca gagaggtagc cgcggtagcg
     7381 cttaggctca tgccggccga aagaatcagg gtggataata atttattcat ggtcagtatc
     7441 ttaataaaat gatgcaagat tcaatgtatg tacttgtgct tgaataacga atttggaatc
     7501 cgcaagcaat taaaaatatt aagagttagt atattgtatt tataattcat tgaaaataat
     7561 gattttttaa tatctctggt ccttttgcta agatgacggg tcagtctttg ttattcattg
     7621 gtttcatgat tgatttggcc tctttttcat tacttgacgg attccaaatc cgattgggga
     7681 attccaaatt cgctacaagt tgccatccaa aaggaataat aaatatgaag aaaacactga
     7741 catttttaat cgcgatggga agctttgctg tttcctcgga ggcagcgacc gtttttaatt
     7801 attacactcc cggtacggat aattacaata gtaccatcca tgggttttat cttggcctgg
     7861 ggtcttcttc cctggctcct tccgattcct cttctccctc ctccctgtcc ggagagatca
     7921 gactggacag ttttacgctg cgcggagccg ccaacggttt gggcgctaat gtcacttacg
     7981 gcttcctggt gctgaatggc tccgacaatt cggtcatcgg ctggagcacc aatacgggaa
     8041 ctactgcagc agggattaat ctgacgttca gtttttcttc cctggatggt tctcccctgc
     8101 ttcttgacgc ggcattgaca taccgtttcc tggccgtgag ccagtccgtg atggacttga
     8161 tgcaggatac gtctaaaacg tatttatatg ctgcgggggg aacagccgcc cctactgcta
     8221 acacggaagg agataccgta acgatcagcg gcggattgac tgctcccggc atccgcggcc
     8281 attatgacgc cgagggagcg cctggtgatt ctgtcgttat tacgggagcc aacggaacca
     8341 atactttcag cttattatcc ccgattttca cggaaatccg aggggaaatg gtgccggaac
     8401 cagccacggt ttccctgggc ctgctgggac tggccgcgct gatgatgcgc cgccgcaggg
     8461 cttgagcttc ctgatggcga aaaatcggcg gatgagagct gttcttgcgg aacagctctt
     8521 gttttttata tccagagagg aagaattgct tatccgtatg cgggattcat gccctccgga
     8581 aggtacggaa tttccggggg cagggggccg tatccggttt tttccgcatg gcggcaattt
     8641 gctggaaacg tttttgagac gcagtaccgg aaagcttttt ctttaccgga aaatgccgtc
     8701 aaattcggca gcgcgctttt cgtccatatg gtacacagta gctttcacat agcggccttt
     8761 caggccggat agggaccccc tttgcagctc acagacctgg agggccgccg catacatatt
     8821 attcgccgtc ctattccccg gcgctggtat ttcggaagaa cggcaatggg ccccatgccc
     8881 agcacttcat attcttttcc atcgtctgcc ctgatgacgg acgttgcatc aacgatgttt
     8941 cccgacgatg cggctgccgt ggacggcgac tgtatccagc tccgggatga aggaaggact
     9001 gacgcgcatg atatggagca ggtaatgttc attgcagccg gggacgaaat agttccagag
     9061 cgcttctctc gtgacatgtt ccgttcttaa tgcaatgatc atgaagggtt gttctttacg
     9121 gctccccctt ggagaaattc cagaggcggt gcatcgtcat aacgtccgga atgttcatgg
     9181 ggcgcaccac gcggaacccg atcatgcctc cgtccgtcag gtaccagatg cttttagggt
     9241 tttgaggatc ctgacggttc caggcagggg tgctggcgcg gcgcgcagcg cttctcaggc
     9301 tgtccgggtc gtcttcccac gaaccgccgc gaacgatgtg aggggcgccg gggatgatga
     9361 ccagggggtc tttcgcgggc aagccgctcc gtttgccgta ggcatccgga acgtaagagt
     9421 ccaaaaccca ttccgccaca tttccgtgca tgtcccggag tccccactta tttggttttt
     9481 tagagcctgt tttctggtag cggtcattgg agttgttcca gtaccaggcg tactggtcca
     9541 gagaggcttc cccgtttccg taagaatagg cgccggggga gccggcccgg caggcgtatt
     9601 cccattccgc ctccgtgggc aggcggtagt aatgcccggt ctgggcgctc agccattcgc
     9661 agaatttgct ggcggcgtgg tgggacatgg agatggcggg cagaccgtgt tcatagccgt
     9721 gacccatgcc caggttcatg gcggtgtagg gggcggtagg ctgcgtaacg gagtcccaca
     9781 gttcgtcatc cggctgttcc tccagaagct gaccgtcctt ggcgcgcgga cgcccgtttt
     9841 ccatgaaggc cgtataaagt tcccagggga tttccgtttc cgagatccag aagggagaga
     9901 tgctcacttt atgctgcggt ccttcgtccg gtttccggtg cggctcttcc gcggtactcc
     9961 ccatgaggaa cgttcctccc ggtatggcga ccatgcgcag ggaagctccc gccgcgggaa
    10021 ccgtttccgt gtaggattca aaacgtgccg gatttccgga agcttcaatg agctgatgga
    10081 tttggcgcgt cgtgccgacc agctcccggg acggcaggtc atccggaatg ggaagggcag
    10141 gaccggcagc gcggtccagt tcccgttttt gcagcgcgga tcggctttct ccccactggc
    10201 gtgcgctggt aatgcgcgcg gcatcttccg tggccgggcg gggggaatta ttttcttccc
    10261 ggcacccggc cagcaggacg cttcctccca gaaagcagga aacaaggaaa atgccgcgca
    10321 tggaatggtg aaaaccggaa tgccctacat cgtcatgcct ccgtcgcagg caatgacctg
    10381 cccggtgatg taacgggcat cgtcagaggc aaggaaggcc gtcagggcgg cgatatcttc
    10441 cacggaacct tgttctttca aaggtatttt cttaacgatt tcttccttga gattgtcggg
    10501 aatggcattg gacatttccg tggagatgaa gccgggagca atggcgttgc acgtgacttt
    10561 gcgcggagcg aattcctgag ccagtgattt ggtgaaaccg atgaggcccg ccttggaagc
    10621 ggcgtaattg gcctggccga tgttgccgac gagaccgatg acggagctca tgttgatgat
    10681 gcgcccggcc ggggatttca tgagaacgcg ctggagggcc ttgaccgtat tgaacgcgct
    10741 tttcaggttg gtgtccagaa cggcatccca gtcttcctct ttcatgcgga gcatcaggga
    10801 gtcccgcgtg atgccggcgt tgttcaccag gatgtcaatc tgcgggaagt ctttcaaaat
    10861 ggcggccatg gtttcctgaa cggccgcgta atccgctacg tcgcaggggt aggccttgca
    10921 ggaatccgga aattccttgt tgatttcttc tgcggccccc ccgcagctgg atggactgcg
    10981 gctgatcagg atgaccctgg ctccttccga agcgaagcgg cgcgcgacgg cattgccgat
    11041 tccgcggccc gcgccggtaa cgatggctgt tttacctgct aacttttgca tgctgcccac
    11101 agtaaacccg tttttcacgg ttccggcaag cttgaaatgg acttggccgc gcaggaaccc
    11161 atacggggaa agggcgtgcc gggaatgaaa aaaggggggg agaaacgggg cggggggcta
    11221 ctgtccggcc tcttcatttt cccggagtgc accggggggc gcaccgtctt catccggttc
    11281 tgccaggtcg ctgaattcat ccgaattttc caaaatgtcc tttaaggcgg cggaaccgta
    11341 atagcgggcc tcaaacaggc gtttgccttc ctgcctgcag cggttgtcca gcatttccat
    11401 tcgtttttcc attttttcca tcagggcgtc ttctttctcc ttttccgcat cgttcaattt
    11461 atcctgaagc tggaggaaat gccggatgtc cttctgaatg tcctgcagcg ttttgacggc
    11521 gttgtccgcg ctttccttgt cctgaacgcc tgccaacgtc tgctggatat tgatggcaaa
    11581 ggaaaaggcc tggttgatca gggattccgc ggaaggaatt ttttccgccg gagccgctgc
    11641 tgcgggggaa gccgttccgg cggccgtttc accaaatgca agagaggctc cggacagaag
    11701 cgcagaatat aagagaggaa caagaaaagc cttcatcctg ttcttttaag gcaggatgaa
    11761 atccacggca aggaaaaagg ggaaactgaa aaagagcctt attccgccgt gatgccgcct
    11821 ttttcatcgt ccagaatgcc tgacttttcc agatagtagt catatccgcc tgcgtaggcg
    11881 gtgatggtcc cccggttcac atgcagggtt ttttgtgcca gggaacggat gaagtgcaca
    11941 tcgtgggaga tgaagaccag tgttccttca taatgcttca gagcctgcac cagggcttct
    12001 acggacaaaa ggtccaggtg ggtggtcggc tcgtccatca gcaggaggtt gggcggatcc
    12061 accaggaatt tgaccaggct gagccgcgat ttttccccgc cggaaagaac gctgacgcgt
    12121 ttttccacat ccagcctccg gaacaggaag gaacccagga tggaacgcgc ttcttcctcc
    12181 cggatttcag cgctgcattt catgatttcc tccagcacgg tattttccgg gttcaggttt
    12241 tccgttcgcg cctgggagaa gtagccgatg cgcgtcgtgg taccgggagt gcgttgtccg
    12301 gagtcaatgg ggatgatgcc cgccaggatt ttgagaagag tggatttgcc cgcgccgttc
    12361 gggcctacaa gaacagtgcg ctccccgcgt tccaccagca ggtccaaatt ttcataaacc
    12421 ctgcggtcgc cataggattg gcagactttt tccagctcaa tgactttctg ggtgctgcgc
    12481 ggaggctggg ggaagttgaa tttaaatact ttcctgcagg ctaccggttt ttgaatgatt
    12541 ttcatctttt ccagctgctt gatgcggctc tggacttgcc cggctttgga attgatggag
    12601 cggaaacggt caataaattc ctgaatgtgc gctatttcct tctgctggtt gcggtaggcc
    12661 gcctgaagct gctcgaagcg cacgtccttt tgttggagga agtccgagta attgccgcgg
    12721 tattccacca gttcttcgtt gtcgatgtcg tacacgcttt ccaccagctc atccatgaaa
    12781 tcccggtcgt gggaaatcat caggatggct ccggggtagt ttttcaggta tcgctggagc
    12841 cacagcaggg acaggaggtc caggtggtta gtaggttcgt ccagcatcag gaggtccggc
    12901 tccaggacaa ggagcttggc caggtacgcg cgcataatcc agccgccgga catttcccgg
    12961 gcggggcggt ggaagtcgct ttcccgaaag gccagccctt tgagaatttt cttggctttg
    13021 ggctccagct ggtaaccgtt ggcggcgttg aaggtgtcaa tggcttccgc gtattccggc
    13081 gtatccgttt tgttggcgtt ttccgccgtc cggatggtgt ggatggcctg ttccatttcc
    13141 ggcgtgatgc ccagggcgat ttccaggacg gtttcatcct tcggttcgct ggcttcctgg
    13201 ggaagatagc ccacgatggc gtattcatcc atgctgatgg agccttcgtc cggcgtgtct
    13261 tctcccagaa tcatgcggaa cagggtggat ttgcctgctc cgttggggcc aaccagagcc
    13321 acccgttccc cccagttaat ggtcatttcc gtttccctga acaaggtccg tccggcgtgg
    13381 gattttgtga gatttttgat cgtcagcatg gtgaagagag gatgtattct accgggatgg
    13441 aaaggggaag gcaagagccg tcagggcgga ggcaggcatt tttgaaagct ttactggatt
    13501 tttacgcgta gtctgctagc cttggcgcgc catgccgacc acgcagacat tcaggctttt
    13561 gcttgctgcc gcccttttgt gcggatggag ttcctgctgt actcctccgg cggaggatta
    13621 tatacaaaaa ccttacgtgc agcagcaaat gtccgggctg gctaatgcct tcctggcgct
    13681 gctgccgccg gatcaggccg ctcttcccgc tgccggagcg gaggccaggt ggctggcgga
    13741 cacggccgtg gtccagtccg ccgcgattgc ccgggacaac aggactgtgc tgtttggctg
    13801 gctgaacaat attctggtca attccaacct gcgcgacagg gggctgtgct ggcaggtcca
    13861 gcaggatttg taccgggacc tgcgccgccg ccccgtgaag tatttccgca tagggctgac
    13921 gattcgagac cgtggaacgg gcagggagca cagttgcgtg tatgtcaatg ccgcggggaa
    13981 gggattgcag ggctccattg ttctggatgc ctggaagaac tgcgggcatc tggtgacgct
    14041 gacccagaag gaccgggaag gcggcaaatg ggaggaggac tggcgggaac catttgtttc
    14101 caaggccttt ccggagggcc attcctacgg catggaacat cacctggtct ggcccgggtg
    14161 ggccaggaaa cgccccatgc tggttcagcg gatattccag tccgatcagc agaatgaggc
    14221 gaaggcggcc gctgaataaa ggggaagcct gatccggcag gaatcggcac acggtgctgc
    14281 accgcggcgg tttgcggtat ccgccgtttt taaggaaaat cccggcgaat cggcaaatgg
    14341 cggagggaat ccggactcag ggcaaataaa aacgcactca gtgcgtacac cgagtgcgga
    14401 ttaattggat aatttgctag tgttgcaggg caaaaccccg ctgcaaactt acttgccctt
    14461 ggcctgcaca accggagcgg gagcaggagc ggtggtttgc tgttgctgct gctgctggga
    14521 gcaagaagcg accaggcaag cggcgccggc gatggcgagg atagcgatgt tcttcataat
    14581 tcgaattaaa tacagtgttt gttaactact ggaacctccg catccacgga ggtttgctgg
    14641 caccaatgta aatggtggca agtagaaatc aagagatttt cttgttccat gtcacggcat
    14701 tacagaaaag agcaggaccc ccggtttctg aag
//
