LOCUS       c00008_gnlPro..        14734 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CKOKCHHB_8.
ACCESSION   c00008_gnlPro..
VERSION     c00008_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 15:55:38
            Original ID  :: gnl|Prokka|CKOKCHHB_8
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14734
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..582)
                     /locus_tag="ctg8_1"
                     /transl_table=11
                     /translation="VRLSGQPDPDPLPFEAIRIHEERKVGPPSTSADGHSAHGTFTIPE
                     GAEGKKLYGTCSLFLGVDDWGILEVKDSGGNVVAQVDLKENPQTAGEQGGHKYHTGTGG
                     AQLPSGTYSWEVSQTNIDYNPASGNTSICNYSIDVVPTEPGGRKEPEPCPCEGDTCDNS
                     GGTPPSPPQARSCPEAGMESGALGNYSSAGG"
     protocluster    1..14734
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1244:4734]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1245..4734
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14734
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14734
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(1245..2012)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_2"
                     /sec_met_domain="Fer2_3 (E-value: 2.2e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 7.5e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.3e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(2053..4011)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.2e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(4033..4734)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_4"
                     /sec_met_domain="SucD_FumR (E-value: 2.6e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             4935..5207
                     /locus_tag="ctg8_5"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             5210..6025
                     /locus_tag="ctg8_6"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAGDILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(6059..6292)
                     /locus_tag="ctg8_7"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(6724..7431)
                     /locus_tag="ctg8_8"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATSLLDSSIVGYSDFASQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLTKINTPDAYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYNGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             complement(7462..7551)
                     /locus_tag="ctg8_9"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKHKYIH"
     CDS             8137..8466
                     /locus_tag="ctg8_10"
                     /transl_table=11
                     /translation="VSQSVMDLMQDTSKTYLYAAGGTAAPTANTEGDTVTISGGLTAPG
                     IRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEMVPEPATVSLGLLGLAALMM
                     RRRRA"
     CDS             complement(8684..8818)
                     /locus_tag="ctg8_11"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGRYVKATVYHMDEKRAAEFDGIFR"
     CDS             complement(8930..9103)
                     /locus_tag="ctg8_12"
                     /transl_table=11
                     /translation="MIIALRTEHVTREALWNYFVPGCNEHYLLHIMRVSPSFIPELDTV
                     AVHGSRIVGKHR"
     CDS             complement(9117..10322)
                     /locus_tag="ctg8_13"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSVLLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMVAIPGGTFLMGSTAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDVMTMHRLWNFSKG
                     EP"
     CDS             complement(10346..11119)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_14"
                     /sec_met_domain="adh_short_C2 (E-value: 2.7e-75, bitscore:
                     244.9, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILI
                     SRSPSSCGGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGIT
                     RDSLMLRMKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQA
                     NYAASKAGLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKE
                     QGSVEDIAALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(11219..11737)
                     /locus_tag="ctg8_15"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LMEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLAEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             complement(11800..13365)
                     /locus_tag="ctg8_16"
                     /transl_table=11
                     /translation="LFRETEMTINWGERVALVGPNGAGKSTLFRMILGEDTPDEGSISM
                     DEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAENANKTDTPEYAEAIDT
                     FNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYLAKLLVLEPDLLMLDE
                     PTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDIDNEELVEYRGNYSDF
                     LQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQSRIKQLEKMKIIQKPV
                     ACRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVERGERTVLVGPNGAGK
                     STLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVLEEIMKCSAEIREEEA
                     RSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLMDEPTTHLDLLSVEAL
                     VQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYDYYLEKSGILDDEKGG
                     ITAE"
     CDS             13533..14240
                     /locus_tag="ctg8_17"
                     /transl_table=11
                     /translation="MPTTQTFRLLLAAALLCGWSSCCTPPAEDYIQKPYVQQQMSGLAN
                     AFLALLPPDQAALPAAGAEARWLADTAVVQSAAIARDNRTVLFGWLNNILVNSNLRDRG
                     LCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCVYVNAAGKGLQGSIVLDAWKN
                     CGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGMEHHLVWPGWARKRPMLVQRIF
                     QSDQQNEAKAAAE"
ORIGIN
        1 gccccccgcc gagctgtagt ttcccagggc gccgctttcc atgcccgcct cagggcacga
       61 ccgggcctgc ggcggggagg gcggcgttcc gccgctgttg tcgcacgtgt ctccctcgca
      121 gggacacggt tcgggttctt tcctgccccc cggttccgtc ggcaccacgt cgatgctgta
      181 gttgcagatg gaggtgttgc cgcttgccgg attgtagtcg atgttggtct ggctgacttc
      241 ccagctgtag gtgccggagg ggagctgcgc cccgccagtc cccgtgtggt atttgtgccc
      301 gccctgttcg cccgccgtct gcgggttttc tttcagatcc acctgcgcca ccacgttgcc
      361 gccggagtcc ttcacctcca ggattcccca gtcgtccacc ccaaggaaga gcgagcaggt
      421 gccgtagagt tttttgccct ccgctccttc cgggatggtg aatgtcccgt gcgcgctgtg
      481 cccgtccgcc gacgtgctcg gcggccccac tttcctttcc tcatggatcc ggatcgcttc
      541 aaacggcagc ggatcgggat ccggctggcc ggataagcgc acgcggcgag tagagccgga
      601 ttggctggca ccggaaccaa agtaccattt ccggtaagcg ggaacggcag aacgatgggc
      661 ggaggaggaa cgatgaggcg gattcatcag gtattcaaga gttgggagta atgaatgaag
      721 cgaggggtgg ccgccctttc ctgatcgttt tatcaatagt atgatccgaa gtcggtgtcg
      781 atagaatttt atttgtatgt ttttgatttt ttataaaaga tggtcattat tttacacgaa
      841 aagataatat tataattctt acgttcagtg cattccctta atagacatca atgttgtctg
      901 tttgttagaa aatgtttccc tctcatgctg agcccttgac aggatgccat cccttccggg
      961 catcagtcta attcctgtaa tcaatgtttc tttctctcga agaaagatgg gggccgtcgc
     1021 tgtcggaagg gggcttgctt aggtttcgtc cggcatttcc aagtacagtc tcctggatta
     1081 ctgggaacct tccagtgtaa catttatttt ttacgctgcg cgacgatgag gaagcaactg
     1141 tctgatattt tattcctggt tcaaggaaac ctgataatga aaaaaactcc cgacagccga
     1201 tgccgccggg agtttttaca gagcgtctta agaaggaatc ttctttagaa acagagacct
     1261 tccttggcgt tggctcgcat gaagtcgcgg ttgaggcggg cgatgttgtc cacgctgatg
     1321 cctttcgggc aagcagcttc acattcatac tggttcgtgc agttgccgaa gccttccgct
     1381 tccatttgct tcatcatggc caggacgcgc ttggaacgtt ccggctggcc ctgcggcagc
     1441 agattgagat gggcgatctt ggcggaggtg aacagcatgg cggaggcgtt tttacaggag
     1501 gccacgcagg cgccgcagcc gatgcaggcg gccgcgtcaa aggcggcgtc cgccttcact
     1561 ttttccacgg cgatgttgtt ggcgttcggc gcggaaccgg tacgcacgtc aatatagcct
     1621 ccggcggcga tgatgcggtc cagggcggag cggtccacca tcaggtcccg caggattggg
     1681 aaagccttcg cgcggaaggg ttcaatccag acggtatcgc cgtccttgaa cttgcgcatg
     1741 tgaagctggc aagtggtcac ctggcgttcc ggcccgtggg gaatgccgtt gatggtcagg
     1801 gagcacatgc cgcagatgcc ttcccggcag tcgtggtcaa aatggatggg ttccttgcct
     1861 tccttgacca ggccttcatt gacgatgtcc agcatttcca ggaaggaggc gtccaccgga
     1921 atgtccttgg cggcataggt ctcaatgcgg cccttggctt cccggttttc ctggcgccag
     1981 accttgagag tgagattgag tgttttagcc atgttataat ctttcttttg agtgttaatg
     2041 tattggctat ctttacttgt agctgcggat ggcaaggtgc acgttctcga aggtcagcgg
     2101 ttccttgtgg agaacaggca ggctgtccac gccagtgtat tcccaggcgg ctacataggc
     2161 gtattcatcg tcgttgcgct tggcttcgcc gtccggcagc tggtattcca cgcggaagtg
     2221 ggcgccgcag gattcctggc ggttcagggc gtcatagcag agcagctggg cgaattccag
     2281 gaagtcggcc acgcggcagg ctttttccag ttccgcgttg atgccgtccg ccgtgccggt
     2341 tacgcgcacg ttttcccaga attccttgcg gagctgggga atgcgttcaa tggcgtgggt
     2401 caggctttct tccgtgcggg ccatgccgca gtcttcccac atgatgaggc ccagttcccg
     2461 gtggaaggag tccaccgtct tggtgccctt cacattcagg agcttgttga tgcgttcctt
     2521 cacttcgtct tccgcagcct tgaattccgg ggcggcggtg gtgacggcac cgggcttggt
     2581 ggtcgtcagg taagcgggca gcgtggcggg aatgacgaag tagccgtcag acaggccctg
     2641 catcagggcg gaggctccca ggcggttggc gccgtggtcg gagaagttgg cttcaccgag
     2701 gacgtgcaac cccttcacgt tggacatgag gttgtagtcc acccacaggc cgcccatggt
     2761 gtagtgggag gcggggtaga tcatcatggg cgtttcatgg gggtcgtcgt ccgtgatttc
     2821 ttcgtacatg tcaaacagat tgccgtattg gccgtcaatc cattcgcggc ccatgcgctt
     2881 gatttcatcc gcaaaatcca ggaagacgcc cttgccggtg acggccacgc cgcggccgtc
     2941 gtcgcaggct tccttggcgg cgcgggagga aatgtcgcgc ggagccaggt tgccgaagga
     3001 gggatacttg cgttccaggt agtagtcccg ttcttcttcg ggaacatcgg aaggcttgat
     3061 ttccttctta cggatttttt ctgcggtttc acgggacttg ggcacccaga tgcggccgct
     3121 gttgcggagg gattccgaca tcagcgtcag tttggactgg tagtcgcctt tgaccggaat
     3181 gcaggtgggg tggatttgcg tgaagcaggg gttggcgaag aaggcaccac gcttgtaggc
     3241 tttgtaggcg gcagtgacgt tgcaacccat cgcgttggtg gacaggaaga acacgttgcc
     3301 gtagccgccc gtgcagagca ggacggtatc ccctgcgtag gatttgattt cgccggtaac
     3361 cagattgcgg gtgacgatgc ccttggcttc gccgtccacc agcaccagat ccatcatttc
     3421 atggcgggag aacatttcaa tgtgtccctt ggccacttcc ttttccaggg cctggtaggc
     3481 acccagcagg agctgctggc ccgtctgtcc gcgtgcgtag aaggttcgct tgagctgggc
     3541 gccgccgaag gagcggttgt ccagcaggcc gccgtattca cggccgaagg gaacgccctg
     3601 ggccacacac tggtcaatga tgttggagga gacttccgcc agacggtaga cattggcttc
     3661 acgggcgcgg aagtcgccgc ctttaacggt gtcgtaaaac aggcggtaaa cggagtcgcc
     3721 gtcgttctgg tagttcttgg ccgcgttaat gccgccctgg gccgcaatgg agtgggcgcg
     3781 gcgggggctg tcctggtagc agaagcattt gacgttgtag ccaagttcgg caagcgtggc
     3841 ggcagcggag gcgccagcca ggccggaacc taccacaagt accgtgtact tgcgcttgtt
     3901 gttcggattg atcagtttgg actcaagttt gtatttggac catttgtcct gaatagggcc
     3961 ggagggaatt ttggcatccg gcatccagtc gcttacggga aaattaatca tgactttgag
     4021 aggagttgat ggttatttga tgatacccag aagaaccgag accggcacgg agatgaagcc
     4081 caggcagata atcgcgccgt aggcgatggc gataaagttg tagaagggcc ggattttgcg
     4141 ggaatcgacg cccacagtct ggaagatgga ctgtaccccg tggcgcagat ggctgaacag
     4201 catcagaacg gccaggatgt agaaggcgga gcaccatacg ttggagaatc cggtcacgat
     4261 catcttgtac acgtcaaagg tttccaccgt accgtcggaa atgaaggtgg tgaactgggc
     4321 ggggtcgtat cccacgcgca gggtgtactg gtacaggtgg tagatcagga acaccaggac
     4381 ggtcaaaccg gtatagatca tgtagcggga ggagagcgtt gccttaatgg tgttcttgaa
     4441 cacgtagggt tcgcgggccg catggttttc cagcttcagc tggatggtca gccagacgtg
     4501 gatgatgaag atcaccgcaa gccccgcgcg gattccccag agggctgctt ccggcatgga
     4561 gtgcaggccg tgggcgtagg tgttgatcca ttcagggcct ccgaagatga gaaggttgcc
     4621 tgccaggtgt cccgcaagga acaagaccaa acataacccc gtcagagcca caatgatttt
     4681 gcggccgatg gaggatgtca cgaatgtaca tatggttttt actagtgcat tcataggcgc
     4741 tctaatgaaa taaatgcgtc ttcacaggat gcccggttca agcccggatg gcaagcctct
     4801 tcttgaattt ccggcgcttt tcggattttt gaaaaaccgg ggaaagaggt tgctgtttat
     4861 cagtttggaa tggttatcat tttgttgcct gttccggctt gacgaggctt tccgcatagg
     4921 cgtatcgtct gtgcatgaaa agaagtaaaa aggaggtgct ggacgcggat ttcgcagcgg
     4981 cgcgcgccgg cgttctggat gtggccgcat ttctggaccg ggtggaccgc ggggaagggg
     5041 aggcggattt ccgctaccat gccctgatgg atgttcttcc cctcttgtcc gcatccggcc
     5101 ccggacgcgt ccgggccatt ctggaagccc tttcctacag ggatgacacc gtgccggaaa
     5161 ccgccgcagc caaagcggcc tgcggagccc cgaacctcag caaataagaa tgatggcttt
     5221 catagaacct catatacata tggtgtgccg caccacggac gaataccggg ccatggcgca
     5281 ggccggctgc ctggcggtag gggaaccggc gttctgggcc ggttacgacc gttcgtccgc
     5341 ggacggtttc cgggattatt tcgtacagct tacggaatgc gaacccgcca gggcggccaa
     5401 gttcggcatg gaccattaca catggctgtg catcaatccc aaggaggcgc aggacgtggc
     5461 tttcgcgcgg gatgtgatga aactgattcc ggagttcatt gaccggccca atgtcctcgg
     5521 catcggggaa atagggctga accggaatac ttcccatgaa atgactattt ttgaagagca
     5581 tctggatctg gcggtgcgcc tcaaccagct tgtgctgatt cacactcccc atctggaaga
     5641 caagcttaag gggaccgtaa tgattctttc cgccctgaaa aaccgtccgg atctggaccc
     5701 ttgccgcgtg ctggtggatc actgtgagga acataccttc ccgctggtga aggaggccgg
     5761 ttactgggcc gggctgaccc tttatcccac cagtaagctg aatcccaagc gggcggggga
     5821 tattctggaa ttgtacggaa tggaccgtgt ctgggccaat tccgcggcgg actgggggga
     5881 ttccgatccc ctggcgctga cggccctggc ctgcgagctg cgcaggcgcg gtttttcccg
     5941 gcaggaaacg gaacgtcttc tcctggaaaa tccggagaca ttcatgggac agtccccgaa
     6001 gttccggaaa gtgtcgtccc gctaattccg cccgaggcgc ggcggagggt acggccctct
     6061 agtccccgtc cgggaaaaag acggtgagga cggcgcccag gatgaccgcc gcgtcatcca
     6121 gaaggcccag cctgccgatt ccgtcaaaca ggaattcgtc gggagtcagg atgtaggcgc
     6181 cggcggcggc cagaaggcat atattccgtt tgttgaaaaa acgcggttct ccttttctgc
     6241 ttttgaaata ccggaacagg cgcagtagca gctgctgttt ttgaaggttc atggacggga
     6301 acgggggata aaggttcaag ctcggccatt ttcccactcc ttttccctgt ttcggggaag
     6361 gagtctgttg ccgacggacg gaaaccgcag cgatccggac cgtgcgggga aatggattgc
     6421 tgaaaggatg ggctgttccg gatgctgagg gaagccgggc tttgcatgct ccggttccgg
     6481 ctgtcccggc atgggaaaaa ggggcgtgta cggaagtggg gcggggccgg aagctcttga
     6541 aatgaccctc ccgggggagc ctgaatgcca tttccccgtc aagtgctggc cgtgagggta
     6601 ccgcagcaaa tggaagcttc ttcccccctg ttttttccgg cagatgtttg aacggataag
     6661 gaaaaggccg gctcacgatt ttgtgagccg gcctttgaat atagggaggc ggacggtaca
     6721 ggcttatgcc ctgcggcggc gcatcatcag cgcggccagt cccagcaggc ccagggaagc
     6781 cgtggcgggt tccgggatgc tggcgatttc actcatcagt tgaccaactt gttcctggga
     6841 aaggagggag tcgtggatgt agagctgttc gatggattca gccagtcctg cgtccatgag
     6901 aatctgatca atttgctggt tgccgaattt caggccgctg ttggaatagt acgtagcgct
     6961 gtctccaaaa tagatgcggg tgccaagatc tccggtgact acggaaatgg tcagggaacc
     7021 ttccgtgccc agcggggtgt caacgacggg cccgttgtat gaggtgttgt tccataatcc
     7081 ctggagtttc cggtccgtgt tcaggcccac gccccagctt acactgctgt ttttggcgtt
     7141 aaacagagcg gtataggcgt ccggagtgtt gattttggtc aggtcaagaa ccatcgtcac
     7201 agacataacg tcgcggttgt tggcaccgta tccgttgaag gttatcccgg ataacgtcag
     7261 attgctgtcg tcagacgtga tggaaacgga atctttcagg gtgccgaaat ccgccgtttg
     7321 ggaggcaaag tccgaatatc ccacgatgga gctatccagc agagaggtag ccgcggtagc
     7381 gcttaggctc atgccggccg aaagaatcag ggtggataat aatttattca tggtcagtat
     7441 cttaataaaa tgatgcaaga ttcaatgtat gtacttgtgc ttgaataacg aatttggaat
     7501 ccgcaagcaa ttaaaaatat taagagttag tatattgtat ttataattca ttgaaaataa
     7561 tgatttttta atatctctgg tccttttgct aagatgacgg gtcagtcttt gttattcatt
     7621 ggtttcatga ttgatttggc ctctttttca ttacttgacg gattccaaat ccgattgggg
     7681 aattccaaat tcgctacaag ttgccatcca aaaggaataa taaatatgaa gaaaacactg
     7741 acatttttaa tcgcgatggg aagctttgct gtttcctcgg aggcagcgac cgtttttaat
     7801 tattacactc ccggtacgga taattacaat agtaccatcc atgggtttta tcttggcctg
     7861 gggtcttctt ccctggctcc ttccgattcc tcttctccct cctccctgtc cggagagatc
     7921 agactggaca gttttacgct gcgcggagcc gccaacggtt tgggcgctaa tgtcacttac
     7981 ggcttcctgg tgctgaatgg ctccgacaat tcggtcatcg gctggagcac caatacggga
     8041 actactgcag cagggattaa tctgacgttc agtttttctt ccctggatgg ttctcccctg
     8101 cttcttgacg cggcattgac ataccgtttc ctggccgtga gccagtccgt gatggacttg
     8161 atgcaggata cgtctaaaac gtatttatat gctgcggggg gaacagccgc ccctactgct
     8221 aacacggaag gagataccgt aacgatcagc ggcggattga ctgctcccgg catccgcggc
     8281 cattatgacg ccgagggagc gcctggtgat tctgtcgtta ttacgggagc caacggaacc
     8341 aatactttca gcttattatc cccgattttc acggaaatcc gaggggaaat ggtgccggaa
     8401 ccagccacgg tttccctggg cctgctggga ctggccgcgc tgatgatgcg ccgccgcagg
     8461 gcttgagctt cctgatggcg aaaaatcggc ggatgagagc tgttcttgcg gaacagctct
     8521 tgttttttat atccagagag gaagaattgc ttatccgtat gcgggattca tgccctccgg
     8581 aaggtacgga atttccgggg gcagggggcc gtatccggtt ttttccgcat ggcggcaatt
     8641 tgctggaaac gtttttgaga cgcagtaccg gaaagctttt tctttaccgg aaaatgccgt
     8701 caaattcggc agcgcgcttt tcgtccatat ggtacacagt agctttcaca tagcggcctt
     8761 tcaggccgga tagggacccc ctttgcagct cacagacctg gagggccgcc gcatacatat
     8821 tattcgccgt cctattcccc ggcgctggta tttcggaaga acggcaatgg gccccatgcc
     8881 cagcacttca tattcttttc catcgtctgc cctgatgacg gacgttgcat caacgatgtt
     8941 tcccgacgat gcggctgccg tggacggcga ctgtatccag ctccgggatg aaggaaggac
     9001 tgacgcgcat gatatggagc aggtaatgtt cattgcagcc ggggacgaaa tagttccaga
     9061 gcgcttctct cgtgacatgt tccgttctta atgcaatgat catgaagggt tgttctttac
     9121 ggctccccct tggagaaatt ccagaggcgg tgcatcgtca taacgtccgg aatgttcatg
     9181 gggcgcacca cgcggaaccc gatcatgcct ccgtccgtca ggtaccagat gcttttaggg
     9241 ttttgaggat cctgacggtt ccaggcaggg gtgctggcgc ggcgcgcagc gcttctcagg
     9301 ctgtccgggt cgtcttccca cgaaccgccg cgaacgatgt gaggggcgcc ggggatgatg
     9361 accagggggt ctttcgcggg caagccgctc cgtttgccgt aggcatccgg aacgtaagag
     9421 tccaaaaccc attccgccac atttccgtgc atgtcccgga gtccccactt atttggtttt
     9481 ttagagcctg ttttctggta gcggtcattg gagttgttcc agtaccaggc gtactggtcc
     9541 agagaggctt ccccgtttcc gtaagaatag gcgccggggg agccggcccg gcaggcgtat
     9601 tcccattccg cctccgtggg caggcggtag taatgcccgg tctgggcgct cagccattcg
     9661 cagaatttgc tggcggcgtg gtgggacatg gagatggcgg gcagaccgtg ttcatagccg
     9721 tgacccatgc ccaggttcat ggcggtgtag ggggcggtag gctgcgtaac ggagtcccac
     9781 agttcgtcat ccggctgttc ctccagaagc tgaccgtcct tggcgcgcgg acgcccgttt
     9841 tccatgaagg ccgtataaag ttcccagggg atttccgttt ccgagatcca gaagggagag
     9901 atgctcactt tatgctgcgg tccttcgtcc ggtttccggt gcggctcttc cgcggtactc
     9961 cccatgagga acgttcctcc cggtatggcg accatgcgca gggaagctcc cgccgcggga
    10021 accgtttccg tgtaggattc aaaacgtgcc ggatttccgg aagcttcaat gagctgatgg
    10081 atttggcgcg tcgtgccgac cagctcccgg gacggcaggt catccggaat gggaagggca
    10141 ggaccggcag cgcggtccag ttcccgtttt tgcagcgcgg atcggctttc tccccactgg
    10201 cgtgcgctgg taatgcgcgc ggcatcttcc gtggccgggc ggggggaatt attttcttcc
    10261 cggcacccgg ccagcaggac gcttcctccc agaaagcagg aaacaaggaa aatgccgcgc
    10321 atggaatggt gaaaaccgga atgccctaca tcgtcatgcc tccgtcgcag gcaatgacct
    10381 gcccggtgat gtaacgggca tcgtcagagg caaggaaggc cgtcagggcg gcgatatctt
    10441 ccacggaacc ttgttctttc aaaggtattt tcttaacgat ttcttccttg agattgtcgg
    10501 gaatggcatt ggacatttcc gtggagatga agccgggagc aatggcgttg cacgtgactt
    10561 tgcgcggagc gaattcctga gccagtgatt tggtgaaacc gatgaggccc gccttggaag
    10621 cggcgtaatt ggcctggccg atgttgccga cgagaccgat gacggagctc atgttgatga
    10681 tgcgcccggc cggggatttc atgagaacgc gctggagggc cttgaccgta ttgaacgcgc
    10741 ttttcaggtt ggtgtccaga acggcatccc agtcttcctc tttcatgcgg agcatcaggg
    10801 agtcccgcgt gatgccggcg ttgttcacca ggatgtcaat ctgcgggaag tctttcaaaa
    10861 tggcggccat ggtttcctga acggccgcgt aatccgctac gtcgcagggg taggccttgc
    10921 aggaatccgg aaattccttg ttgatttctt ctgcggcccc cccgcagctg gatggactgc
    10981 ggctgatcag gatgaccctg gctccttccg aagcgaagcg gcgcgcgacg gcattgccga
    11041 ttccgcggcc cgcgccggta acgatggctg ttttacctgc taacttttgc atgctgccca
    11101 cagtaaaccc gtttttcacg gttccggcaa gcttgaaatg gacttggccg cgcaggaacc
    11161 catacgggga aagggcgtgc cgggaatgaa aaaagggggg gagaaacggg gcggggggct
    11221 actgtccggc ctcttcattt tcccggagtg caccgggggg cgcaccgtct tcatccggtt
    11281 ctgccaggtc gctgaattca tccgaatttt ccaaaatgtc ctttaaggcg gcggaaccgt
    11341 aatagcgggc ctcaaacagg cgtttgcctt cctgcctgca gcggttgtcc agcatttcca
    11401 ttcgtttttc cattttttcc atcagggcgt cttctttctc cttttccgca tcgttcaatt
    11461 tatcctgaag ctggaggaaa tgccggatgt ccttctgaat gtcctgcagc gttttgacgg
    11521 cgttgtccgc gctttccttg tcctgaacgc ctgccaacgt ctgctggata ttgatggcaa
    11581 aggaaaaggc ctggttgatc agggattccg cggaaggaat tttttccgcc ggagccgctg
    11641 ctgcggggga agccgttccg gcggccgttt caccaaatgc aagagaggct ccggacagaa
    11701 gcgcagaata taagagagga acaagaaaag ccttcatcct gttcttttaa ggcaggatga
    11761 aatccacggc aaggaaaaag gggaaactga aaaagagcct tattccgccg tgatgccgcc
    11821 tttttcatcg tccagaatgc ctgacttttc cagatagtag tcatatccgc ctgcgtaggc
    11881 ggtgatggtc ccccggttca catgcagggt tttttgtgcc agggaacgga tgaagtgcac
    11941 atcgtgggag atgaagacca gtgttccttc ataatgcttc agagcctgca ccagggcttc
    12001 tacggacaaa aggtccaggt gggtggtcgg ctcgtccatc agcaggaggt tgggcggatc
    12061 caccaggaat ttgaccaggc tgagccgcga tttttccccg ccggaaagaa cgctgacgcg
    12121 tttttccaca tccagcctcc ggaacaggaa ggaacccagg atggaacgcg cttcttcctc
    12181 ccggatttca gcgctgcatt tcatgatttc ctccagcacg gtattttccg ggttcaggtt
    12241 ttccgttcgc gcctgggaga agtagccgat gcgcgtcgtg gtaccgggag tgcgttgtcc
    12301 ggagtcaatg gggatgatgc ccgccaggat tttgagaaga gtggatttgc ccgcgccgtt
    12361 cgggcctaca agaacagtgc gctccccgcg ttccaccagc aggtccaaat tttcataaac
    12421 cctgcggtcg ccataggatt ggcagacttt ttccagctca atgactttct gggtgctgcg
    12481 cggaggctgg gggaagttga atttaaatac tttcctgcag gctaccggtt tttgaatgat
    12541 tttcatcttt tccagctgct tgatgcggct ctggacttgc ccggctttgg aattgatgga
    12601 gcggaaacgg tcaataaatt cctgaatgtg cgctatttcc ttctgctggt tgcggtaggc
    12661 cgcctgaagc tgctcgaagc gcacgtcctt ttgttggagg aagtccgagt aattgccgcg
    12721 gtattccacc agttcttcgt tgtcgatgtc gtacacgctt tccaccagct catccatgaa
    12781 atcccggtcg tgggaaatca tcaggatggc tccggggtag tttttcaggt atcgctggag
    12841 ccacagcagg gacaggaggt ccaggtggtt agtaggttcg tccagcatca ggaggtccgg
    12901 ctccaggaca aggagcttgg ccaggtacgc gcgcataatc cagccgccgg acatttcccg
    12961 ggcggggcgg tggaagtcgc tttcccgaaa ggccagccct ttgagaattt tcttggcttt
    13021 gggctccagc tggtaaccgt tggcggcgtt gaaggtgtca atggcttccg cgtattccgg
    13081 cgtatccgtt ttgttggcgt tttccgccgt ccggatggtg tggatggcct gttccatttc
    13141 cggcgtgatg cccagggcga tttccaggac ggtttcatcc ttcggttcgc tggcttcctg
    13201 gggaagatag cccacgatgg cgtattcatc catgctgatg gagccttcgt ccggcgtgtc
    13261 ttctcccaga atcatgcgga acagggtgga tttgcctgct ccgttggggc caaccagagc
    13321 cacccgttcc ccccagttaa tggtcatttc cgtttccctg aacaaggtcc gtccggcgtg
    13381 ggattttgtg agatttttga tcgtcagcat ggtgaagaga ggatgtattc taccgggatg
    13441 gaaaggggaa ggcaagagcc gtcagggcgg aggcaggcat ttttgaaagc tttactggat
    13501 ttttacgcgt agtctgctag ccttggcgcg ccatgccgac cacgcagaca ttcaggcttt
    13561 tgcttgctgc cgcccttttg tgcggatgga gttcctgctg tactcctccg gcggaggatt
    13621 atatacaaaa accttacgtg cagcagcaaa tgtccgggct ggctaatgcc ttcctggcgc
    13681 tgctgccgcc ggatcaggcc gctcttcccg ctgccggagc ggaggccagg tggctggcgg
    13741 acacggccgt ggtccagtcc gccgcgattg cccgggacaa caggactgtg ctgtttggct
    13801 ggctgaacaa tattctggtc aattccaacc tgcgcgacag ggggctgtgc tggcaggtcc
    13861 agcaggattt gtaccgggac ctgcgccgcc gccccgtgaa gtatttccgc atagggctga
    13921 cgattcgaga ccgtggaacg ggcagggagc acagttgcgt gtatgtcaat gccgcgggga
    13981 agggattgca gggctccatt gttctggatg cctggaagaa ctgcgggcat ctggtgacgc
    14041 tgacccagaa ggaccgggaa ggcggcaaat gggaggagga ctggcgggaa ccatttgttt
    14101 ccaaggcctt tccggagggc cattcctacg gcatggaaca tcacctggtc tggcccgggt
    14161 gggccaggaa acgccccatg ctggttcagc ggatattcca gtccgatcag cagaatgagg
    14221 cgaaggcggc cgctgaataa aggggaagcc tgatccggca ggaatcggca cacggtgctg
    14281 caccgcggcg gtttgcggta tccgccgttt ttaaggaaaa tcccggcgaa tcggcaaatg
    14341 gcggagggaa tccggactca gggcaaataa aaacgcactc agtgcgtaca ccgagtgcgg
    14401 attaattgga taatttgcta gtgttgcagg gcaaaacccc gctgcaaact tacttgccct
    14461 tggcctgcac aaccggagcg ggagcaggag cggtggtttg ctgttgctgc tgctgctggg
    14521 agcaagaagc gaccaggcaa gcggcgccgg cgatggcgag gatagcgatg ttcttcataa
    14581 ttcgaattaa atacagtgtt tgttaactac tggaacctcc gcatccacgg aggtttgctg
    14641 gcaccaatgt aaatggtggc aagtagaaat caagagattt tcttgttcca tgtcacggca
    14701 ttacagaaaa gagcaggacc cccggtttct gaag
//
