LOCUS       gnlProkkaDEIGDKIO_21   13081 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DEIGDKIO_21.
ACCESSION   gnlProkkaDEIGDKIO_21
VERSION     gnlProkkaDEIGDKIO_21
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 08:14:46
            Original ID  :: gnl|Prokka|DEIGDKIO_21
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13081
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13081
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3816:8081]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3817..8081
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13081
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13081
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(3..281)
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="MNVLVTGAAGFIGSHVCKRLLQRGDEVVGLDNINSYYDINLKYGR
                     LSSLGVPQSELSWYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFD"
     CDS             complement(289..1158)
                     /locus_tag="ctg18_2"
                     /transl_table=11
                     /translation="MIVSSLRGGLGNQMFIYAMVKAMALRNNVPFAFNLTTDFANDEVY
                     KRKLLLSYFALDLPENKKLTFDFSYGNYYRRLSRNLGCHILHPSYRYICEERPPHFESR
                     LISSKITNAFLEGYWQSEKYFLDYKQEIKEDFVIQKKLEYTSYLELEEIKLLDKNAIMI
                     GVRRYQESDVAPGGVLEDDYYKCAMDIMASKVTSPVFFCFSQDLEWVEKHLAGKYPVRL
                     ISKKEDDSGTIDDMFLMMHFRNYIISNSSFYWWGAWLSKYDDKLVIAPGNFINKDSVPE
                     SWFKLNVR"
     CDS             complement(1155..2300)
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="MKILLVFIDMIRVDHLSLYNDNMEKTSLDLFFENLGGTILTNCYT
                     PAPDTPRSIACLQSGLLPYLNGCDSRVKWPRYFMKPNIETIFDIAVGLGYKVNLCATKS
                     DIETGLFKFKENENISIFTTIEDFTDTVHLSENTLSLIAIDDYHSAIDDYGGTSLGIKE
                     GQKVILYSLNNFLTPDIVNKYDYSFFFSDHGHALQSEIVMQKNKLELLSDGRTKLFMFY
                     HNINNKKIVKDSRLASILDLYASIVDLIGSGDFRQGFSFFRDSQRDILHIEDHADFRVS
                     PEQIVSQWRVISDEIDIRTNVFETLNKKGQIIDINVVKKYLDSFSPSFSYYMKQIEILK
                     MYEKMKQRKTHYFNGVKRANWWIRCYVRIINRLYILINRLK"
     CDS             complement(2304..3797)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_4"
                     /sec_met_domain="Polysacc_synt (E-value: 2.6e-09, bitscore:
                     32.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKKNVVKWNFVFYLLEFLYTILVGIILVPLYLKYIPKDLYGFW
                     LATGNILSILTLINPGFSDVIQQKVAYCYGLHDYKKIGLYTVSGICLTFVFSLIVLIIG
                     VVVNLLIGSIFTMQANYLYELKIAFGLMLVGTFLTINYYSFSSILYAFLSSKSIGLIVL
                     LGNSLGTLISIYLIIHGYGLIALGIASVVRGGVFLSCSVGYVIFKFRKKKIKIVFDLNN
                     VKEIFSFSIYNFLGKTGQTLLTNMNSFLTAKFVSPIDAANLRFTQTVPEFGKVLVLRFL
                     YSVAPIIPNLLAAKGLESIRIKLLNIVYFLISFIFLVCIGFYLLNEQFIYLWLGENNFS
                     GKIINFFIIILLFFSSINKVCFQFLFALGDIKKSNKILFYQSLLYLPIAVFTTKFCGII
                     GLLLSGILVELLALFIFFFPKMVDILNISKIDIRKKLFVELTKISFVTVITLLIGSCVK
                     FSNPSWLLFFVEIVFIVLTFFVLLFLCSKTFRNLLSICK"
     CDS             complement(3817..4917)
                     /NRPS_PKS="Domain: Aminotran_5 (30-293). E-value: 6.2e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg18_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_5"
                     /sec_met_domain="Aminotran_5 (E-value: 4.9e-30, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAVLKY"
     aSDomain        complement(4039..4827)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg18_5_Aminotran_5.1"
                     /evalue="6.20E-34"
                     /label="ctg18_5_Aminotran_5.1"
                     /locus_tag="ctg18_5"
                     /protein_end="293"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIK"
     CDS             complement(4914..6050)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_6"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.6e-21, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.2e-19, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(6062..7363)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_7"
                     /sec_met_domain="CTP_transf_like (E-value: 8.1e-11,
                     bitscore: 37.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 5.9e-121, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.9e-63, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(7383..8081)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_8"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.5e-13, bitscore:
                     44.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLSCGIERII
                     LGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLLESDLVFE
                     RKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKGELVGIHK
                     LSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEIDDEADLS
                     YAEEHIIRYC"
     CDS             complement(8095..9378)
                     /locus_tag="ctg18_9"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(9375..9860)
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MNTLTSQIEQLQSLAHELLYLGVDGAPIYTDHFRQLNKEVLEQSD
                     ALYPQRGATPEEEANICLALLMGYNATIYNQGDKEEKKQVVLNRCWDVLDQLPATLLKC
                     QLLTYCYGEVFEEELAKEAHTIIESWSNRELLKAEKEIAESLNNLEANPYPYSELHE"
     CDS             complement(9864..10388)
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MSEQQKYWFAARTRDKQEFAIRDSLEKLKTELDLNYYLPTQFVIR
                     QLKYRRKRVEVPVIKNLIFIQATKQDACDISNKYNIQLFYMKDLLTRAMLIVPDKQMQD
                     FIFVMDLDPNGVSFDNDHLSVGSRVQVVKGDFCGVEGELASEANKTYVVIRIAGVLSAS
                     VKVPKSYLRVI"
     CDS             10910..11248
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MNDNLVTIEVNGKVIFAGKADLQFSLNQKVREPLRITKGKGKLME
                     ALTESFIKGGINSMENRPIEELQETIKEYLTFEYQRKGIATEPNKRSFLSELKKYARAF
                     RKKRDESE"
     CDS             11389..11736
                     /locus_tag="ctg18_13"
                     /transl_table=11
                     /translation="MKKNRKAVSKNEMMKGKWKRQIMLEKDYTEQCSEWMAERLEALIE
                     YMQYGHAAVAYMKQDGTFKLVKGTLVGYEKDFGKQYDPMEIKNTVVYRDVEQQRWMTFK
                     IENFMEWRAIV"
     CDS             11786..12589
                     /locus_tag="ctg18_14"
                     /transl_table=11
                     /translation="MATTYDGINYFPIAVNFMEENAMEVIEAKYGMKGLAIVLKLLCKI
                     YKEGYYIPWGEEQCLIFANKTGKEADAEEVQGIIEIMIEKGMIDRGSYAEHKVLTSEAI
                     QKVWIEATKRRKRNWTAMPYLLIKPKETCNEEKTVCTQNVEQDAGSDAKNACNTEQSKV
                     KQSREFPPSAPPRGKEEEVNATPVSMPGYAFNTMTHNYVGLMGNLERFGITDEKEIEAI
                     LRLSDYGRKGTPVWKLICSTNWSNIGAKGKYMIAALNRAKKRSGT"
ORIGIN
        1 acatcaaaat ttccattagc aaacagcatt tgcatagcct gcctatcctc gaggttcatc
       61 cgcacaaaac taaatcgagg ataaacatta ctccgtgtga acttatacca tgacagttca
      121 gattgaggaa cacctaagct cgaaaggcgt ccatacttta aattaatatc ataatacgaa
      181 ttaatattat ccaagcccac aacttcatcc ccacgttgca aaagacgctt acaaacatgc
      241 gaacctataa atccggcagc accggttact aatacattca ttaagatttt atcttacatt
      301 caatttaaac caagattctg gtacagaatc cttatttata aaattacctg gagcaatcac
      361 cagcttatca tcatatttcg aaagccatgc tccccaccag taaaaagagc tattcgatat
      421 tatataatta cgaaaatgca tcattagaaa catatcatct atagtaccac tatcatcctc
      481 ctttttactt atcaaacgaa caggatattt tcccgctaga tgtttttcaa cccattctaa
      541 atcttgtgaa aaacaaaaga aaacaggaga agtaactttt gatgccataa tatccatagc
      601 acatttatag taatcatctt ctaacactcc accaggagct acatcacttt cctgataccg
      661 tctaacccca atcattatgg cattcttatc tagcaatttt atttcttcca attccaaata
      721 cgatgtgtat tctaattttt tttgtattac aaagtcctct tttatctctt gtttataatc
      781 aagaaaatat ttttctgact gccaatatcc ttccagaaaa gcatttgtaa tcttagaact
      841 aattaacctt gattcaaagt ggggagggcg ctcttcgcaa atataacgat atgatggatg
      901 aagtatatga caacctaaat tacgacttag ccttctataa taattcccat atgaaaaatc
      961 aaatgttaat tttttatttt caggcaagtc taatgcaaaa tatgataata aaagtttcct
     1021 tttataaact tcatcatttg caaaatcagt agtcaaatta aaagcgaatg gtacattgtt
     1081 tcttaatgcc atggccttca ccatagcgta aataaacatt tgattcccca atcctcctcg
     1141 caaagatgat acaatcattt caatctattt attagtatat ataacctatt tataattcta
     1201 acataacagc ggatccacca attagctcgc tttaccccat taaaataatg cgttttccgt
     1261 tgtttcattt tctcatacat ttttagaatc tctatctgtt tcatataata agaaaacgag
     1321 ggggaaaaac tatctaaata tttttttacc acatttatat cgattatttg tcctttttta
     1381 tttaaagttt caaatacatt agtcctaata tctatttcat ctgaaattac tcgccattga
     1441 ctcacaattt gctctggaga caccctaaaa tcagcatggt cctctatatg aagtatatct
     1501 ctttgactgt ctctaaaaaa ggaaaaacct tgcctaaaat ctccactacc aatcaaatca
     1561 acaatagagg cataaagatc caaaatagaa gcaagcctag aatcttttac tattttctta
     1621 ttattaatat tatgatagaa cataaaaagt ttagttcttc catcactaag tagttctagt
     1681 ttattttttt gcatgacaat ttcactctgc aaagcatgcc catggtctga aaagaaaaac
     1741 gaatagtcgt atttatttac gatatctgga gttagaaaat tatttaaaga atataatatc
     1801 actttctgcc cttctttaat tcccaatgag gttcctccat aatcatcaat ggcagaatga
     1861 taatcatcaa tggcaattaa ggacaatgta ttttctgaca aatgaacagt atcagtaaaa
     1921 tcttcaatag tagtaaatat actaatattt tcattttctt taaacttaaa caaccctgtt
     1981 tcaatatcag atttagtcgc acacaaattt actttatatc ctaaccctac tgcaatatca
     2041 aaaatagttt ctatattagg tttcataaaa tatcttggcc atttgacacg actatcgcag
     2101 ccattcaaat agggtaatag gccactttgc aaacaagcta tacttcttgg agtatcaggt
     2161 gcaggtgtat aacagttagt tagaattgta cctcctaaat tttcaaaaaa caaatccaac
     2221 gatgttttct ccatgttatc attatataat gataaatgat caacacgtat catatctata
     2281 aaaactagta gtatcttcat cttttattta caaatagaca ataaattacg aaaagtcttt
     2341 gaacataaaa acaacaaaac aaaaaatgtt aatacaataa aaacaatttc cacaaagaaa
     2401 agtagccaac taggattaga gaacttgaca caagaaccta ttaataatgt aataaccgta
     2461 acaaaagata ttttggttaa ctccacaaaa agtttctttc taatatctat tttcgaaata
     2521 ttaagaatat caaccatttt aggaaagaag aaaatgaata gtgccaataa ttctactaat
     2581 attccagata acaataaacc aattattcca caaaatttcg ttgtaaaaac agcaataggt
     2641 aaatacaaca aagattggta aaataaaatc ttattgcttt tctttatatc tcctaatgca
     2701 aaaagaaact gaaaacagac cttgtttata gaagaaaaaa acaataaaat aatgataaaa
     2761 aaattaatta ttttccctga aaaattgttc tcaccaagcc ataaatatat aaattgttca
     2821 ttcaatagat aaaaaccaat acatactaag aaaataaagg aaatcaaaaa atacacaata
     2881 ttcaaaagct ttattctaat agactccaac cccttagctg ctaacaaatt aggaataata
     2941 ggagcaacag aatataaaaa tcttaaaact aaaactttac caaattccgg cacagtttga
     3001 gtaaatctca aatttgcagc gtcaatagga gaaacaaact tagcagtcaa gaaagaattc
     3061 atattagtca acaatgtttg tcctgtttta cctaaaaaat tatatataga aaaagaaaag
     3121 atctccttaa cattatttaa atcaaataca atttttattt tcttttttcg aaatttaaat
     3181 attacatagc caacactaca tgacaaaaaa acacctcctc gaacaactga tgcaattccc
     3241 aaagctatta gaccatatcc atggataata agataaatag atattaaagt acctaaacta
     3301 ttgcctagaa gtacaattag cccgattgac ttactactaa gaaaagcata taatatagaa
     3361 gaaaaggaat aataattaat agttaaaaat gtaccaacaa gcattaagcc aaaagctatt
     3421 tttaattcat ataaataatt agcttgcatt gtaaatatac tacctattaa aaggttaact
     3481 actactccga ttatcaaaac aattaatgaa aaaacaaacg taagacaaat acctgaaacg
     3541 gtatataatc ctattttttt ataatcatgt aatccataac aatatgcaac tttttgttgt
     3601 atcacatctg aaaacccagg attgataaga gttaaaatag acaatatatt accagtagct
     3661 agccagaaac catataaatc ctttggaata tatttcaaat acaacggaac caaaataatc
     3721 ccaactaaaa ttgtatacaa aaattccaag agataaaata caaaattcca ttttactaca
     3781 ttttttttat ctttcatatc ccaattgaca atttctctag tattttaaaa cagcctccct
     3841 catcacctca aagaacctct caatatcctc cacatcaatc tctcccaacg cacaaagccg
     3901 gaatgtattc gttgtggaaa tcttacccgg gtagatcgta aagccacgtt catagcagta
     3961 atcatgaacc ttatcaaaat cccagagggg atcatcagga tacaatacag aaacaacaag
     4021 acccgactgc cattcacgtt tgatcgcata ctgaagacca agctcttgca aacctttatg
     4081 gatggcttca aagaccctct tgtgacgggc gaatttagcc tcttcaccta ctgcaaaata
     4141 ttcatcaaga gcctgacggg cagcgtaaac ggtttgaaca ggaggagtaa aatgcatctc
     4201 acccgtcttc tcaaagtaat cgtattgtaa atagaggtta caatagtagg agcgtttcgg
     4261 ataatccctt gaagcacgta tcagggattc atcacctatg ataaaggaaa gacccgtcat
     4321 ggcctgaagg cctttctgag ccgaagccat acaaaagtca acattatcct tcccgatatc
     4381 aaaaggaatc atacccaggg aggaagtggt gtcgacaaca aaaacggcac cgtgcgaatg
     4441 ggctattttt ccgatctcac ggatggggtt caagataccc gtacccgttt catggtgcgt
     4501 ggtatagacc aaagcgatgt ccggattgtc ggaaagcgtc ttttcgatta ccgacaggtc
     4561 gggaagttcg taaacggaaa acttcaaatc gatatgggga agaccgtaat attcgcagac
     4621 ttccaccgca cgggtgctat aggcaccgtt attgacaacc agaactttct tatccgcagg
     4681 aagaagagag ttcaggcaga tatcgatatt gatcgtaccc gagccgcaaa acaggacggc
     4741 cgtatgtttg gagaggtctc catgcgcaac gcggaccagg tcgtcacgta actgtttcat
     4801 catacccgca aactctttct cacgcggaca gatatcggga acaacctgcg ccagctttac
     4861 cgtatccgtc gtggtggcgg gacccggatt caaaaggatc tttctttcga tattcatgaa
     4921 tgcgtatctt ttaaaaatgc cataaaatgc tctttattct ctaccggagt agtcgtaggg
     4981 cgacccagat catcacgtga atcgatccgg accttaattt caagaagaac cgggccggac
     5041 aggccggaca gcttctcaag cgcacacgaa agcccttcct tgtcggaggc agtcagtaca
     5101 tgcgcataac cgcaaccttt cgctatcgag gcgatatcca gacggaaacc gagcgtgggt
     5161 tgaccgccga cagattcatg cgcaccgttg ttgaaaagga cgtgcctgta attcttggga
     5221 gaaagatcgc cgatattgct gacagcaccc atgtgcatga taaaggcacc gtcaccgtca
     5281 agacagtaga cacggcggtc aggcttctca agggcaatcc ccagggcaat ggaagaactg
     5341 tgacccatgg aacccacagt taggaaatcc cttgcgtgcc cctgcccttt cgattcacgg
     5401 tactcgaaaa gctcacggga gagcttgccc gtggtggaaa ccacaatgtc attgtccccg
     5461 aggtggtcga caacctgcat tagcgcctcc tcgcgggaca gaggatagtc attcaaggct
     5521 tcctgacgca atttatattt tccaaacgta tctttacgga tgacaatcgc atggggaatc
     5581 gaccggctct tcgccgagac aaccgcgtca tggatctgcg ccagggcctc gtcttcatcc
     5641 gtatccagaa ttataaaagg aattttcatg gctttcagaa gatcaagggt aacctcgccc
     5701 tgcttcttat gctggggttc gtcttttgtg ccgggctcac cgcgccagcc gaccagcaaa
     5761 agaagaggaa ggctgtacac tttctcgtcc gcaagggaca agaggggatt caccgtattt
     5821 cccagaccgg agttctgcat ataaaccaaa ggaacgttgc cagaagccat ataataaccg
     5881 caggcaatgc ccaccgcgga accttcattg gcggcgatga tatgcttacc acgcggagca
     5941 tgatccgtga tataggcgca aatattcttc aaaagggaat cgggaacacc cgtaaagaag
     6001 tcaacaccgt gatgaaggaa cgtatcgtat atcttttcta cacttaccat aaccgtctga
     6061 tttatttagt gcccggaatc aattccagaa tttccttgat aggcatacaa agcggacgga
     6121 cctcctcggc gcgctcgttt tcaaggatgg tcctggccac gttcatcatg gccgggtaag
     6181 cggcacggag aaggtggttg gcgtaaatga ctacgttggc accccattcg tgaagttcgg
     6241 attcgtgcac atggtcataa gtcgtcggaa caacgacaat gggaacatgg gcgtattctt
     6301 tgcggaaagt ccggcagaac tcacggatat cctcacccga cttatccttg ctgtggatca
     6361 tgatgccgtc cgcacccgcc tgtacatagg cataagcacg ttcgagggcg tcactcatgg
     6421 gtttgccggc aataaggctt tcgatacgcg caatgatcat aaagtcaccg gtgacctggg
     6481 cattcttccc tgctctgatc ttatcgcaga aaccctcgat actatcctga gtctggatag
     6541 cgtcagtacc aaaaagggaa ttcttcttca gaccgacttt atcttcaatg attactgcag
     6601 aaatgccatg acgttccaga gtgcgcacag taaagacaaa gtgttcgatc ttgccacccg
     6661 tgtctccatc aaaaataata ggcttggtgg tacattcaag gatattgttc aggtcctgta
     6721 aacgggtggt aaggtcgacc gcttcaatat ccggtttacc cttactcgtg gagtcggtca
     6781 ggctgctgga ccacatgccg tcaaagacct cgcgcttatc ccccttctgg acttcaagat
     6841 tctcaataat cagaccgcaa agaccgtcgt gagcctccag gatacggacc acaggcttgg
     6901 cctggatcag gcggcggagg gacttaagac gtacgtcagg ggtagtcccg atcgccttga
     6961 tatccttgtc gagcgaggag gagttgatgc cccgggtata agggatctcg attaccttgc
     7021 ccccctgggc gttcatcacc tcaaaaacct gttcgcgcac ctcgcgcaac gggcccgttt
     7081 tccagtcgtc gccgtggatg atatagtcag gcttgagttt ttccagattc ggaacatagc
     7141 tccagtcctc ctggggaaca acctcaaaaa cccccttgat attctcaaca acctccttac
     7201 gctgatcata ggtaaggtaa gggaggcgtt tgtgttcggc gatggccttg tccgtcagca
     7261 gaccgacgat gacatcaccg tatttagtag cttcatgaat aatatggatc agccccggat
     7321 gcatgatatc cgcggtcata ccgacataaa ttttcttgtt catatatgga aaagatttgt
     7381 ttttaacaat agcggatgat gtgctcctcg gcatacgaaa ggtcggcttc atcatcgatt
     7441 tcataccatt taagaccctc caccctgagc acacggacag gggaaacgga acgggacatg
     7501 cggagcagtt cgtattcgta acccagttta ggctgggact ccaggatggt cgcataatcg
     7561 gcgcacatcc ggcggtagaa agtattggaa agtttatgga taccgaccag ctcgcctttt
     7621 gcctcaaggg cgttcttgtc taccgaacag gaagtaagga tgtgattgcg gtcatattcc
     7681 acataatact gatcctggaa cttggtcaga gaagagacaa gcatcacatc cgggaattcg
     7741 tcatccagca gcgaaaggat ggccttgcgt tcaaaaacaa ggtccgattc aagcagcagg
     7801 aaactgtcat cgcctatcac gtcacgcgta ttgtacagag tgtacatact gttagtatcg
     7861 gcataacggg gactgaaaca ggtctctatc tgggggaaat ccgcctgaag ggcttcataa
     7921 gcctcttttt tataacccgt accgaggatg atacgttcga taccgcagga aagaagggtt
     7981 tcgatagagc ggataatcat aggttttcca ccaacctcca caaaaccttt gggcacaagc
     8041 tcggtataat gcccgaagcg ggtaccaaga ccggcagcca tgatcattgc tgttttaatc
     8101 atgaatttca gagggaatta atataagtga attcaattgt tgcttgaaat aacagtaaat
     8161 cgcaaaaatc gacaggacag aaacaaatcc tgaaaaaagg gcagtacgca ttagcatgac
     8221 agtccaggaa atgtcagcag aaacgaagtt cttgaccata aacacacccg tagtgcccag
     8281 atagccgaaa gaatcggcca aataaataat aaaaacagcc gtactaacca ccctaaggga
     8341 agcaatcaga cgttctatca ggtaagtgaa aggaatatac cccatataca gaccaagacc
     8401 ggaaagaatc atccaccaaa taggagaaag aaaaccgtac acataaagca atgtggaaaa
     8461 aaccattaag gaaccgcctg tgacggcaat gcaataaatg atattaagag ccaaacggtt
     8521 attacggaca aacacaatca ggaacatcag tacaaggaca aaaacggcaa tgggaacctc
     8581 tgtctgagta aagatcattg caccctcaat atggagctcc ttccaaatat cggcagcgaa
     8641 agagtcacga agctcacgga acacggtcag ggcaccgtaa aaaacaacca gcatgcagat
     8701 tccccagaag aattgcctca aaaatttacg cctgtcttta ccatccatcg gagcacgttt
     8761 ggtacgctgt atgatatctt gctcattggg agccggaatc tgattgagaa gccagctgca
     8821 aagcaacata acagggtata ccaacaaacc tgtggtaaaa ggcatccaat attccgacac
     8881 atgcaaatta tccatcacga attgtcccaa ggttttcacc aaaccggaag agactatcaa
     8941 agcaacgctc agcccgacat tcaatatttc actgatacga cgcccttcga tatagctaaa
     9001 aatgacaccc cagatcatac ccaggggaag accgctcaga aaaatagaac acaccttcaa
     9061 aggaaccgga agaagtgcaa aacccaacaa agcaacttcg gaaaaagtaa gcagccctat
     9121 tatataatag atgcggtgac ccgctttcat cgaaggcaaa atacgaacac cgatgaactt
     9181 ggaaagggcg tagccgataa tctcagaaag gacatacaga attttgacat cgaatcccca
     9241 aagaatctca ccttcataaa tggctgcggt aaatggctta cggtaggcat aggcacaagt
     9301 ataaaccaga aaaatcaaaa cgctggcata gagagccaaa acgtaaaggg gagaacggga
     9361 aagaaaggaa cgaatcattc gtgtagttcg ctgtacggat atggattagc ttccaaatta
     9421 ttcaaacttt cagctatttc tttttcagct tttaaaagtt ctcgattgct ccaactttct
     9481 atgatagtat gcgcctcttt cgccaactcc tcttcaaaca cctcaccata acaataagtc
     9541 aataactggc atttcaataa agtagcagga agttggtcaa gcacgtccca acaacgattg
     9601 agaacaactt gctttttctc ctccttgtca ccctgattat agatggttgc attgtaaccc
     9661 atcaataatg ccagacagat gtttgcttcc tcttcgggag tagcaccacg ctgaggatac
     9721 aacgcatcgg attgttctaa aacttctttg ttcaactgac ggaaatgatc ggtataaata
     9781 ggagcaccat ccacacctaa atagagtaac tcgtgcgcga gactctgtaa ttgttcaatt
     9841 tgagaagtga gtgtattcat aacttaaatg acacgtaaat aacttttagg aactttgacg
     9901 ctggcgctca atacaccggc aatacgaata acaacataag ttttgttggc ctcgctggca
     9961 agttcgccct cgacaccaca gaaatcacct ttaactacct gaaccctgct accgacagat
    10021 aaatggtcat tatcgaaact gacgccattc ggatctaaat ccatgacaaa tatgaagtcc
    10081 tgcatctgtt tatcaggaac tatcagcata gccctggtaa gcaggtcttt catataaaaa
    10141 agctggatat tgtatttatt agaaatatca caagcatctt gcttggtagc ttggatgaag
    10201 ataagattct taataacagg gacttccacc cgttttcgac gatatttcaa ctgccggatg
    10261 acaaactgag tgggaagata gtaattgaga tcaagttcag tcttcaattt ttcaagagag
    10321 tcacgaatag caaactcttg tttatctcgg gtacgggcgg caaaccaata cttctgttgt
    10381 tcagacattt acgatttata cttggggaaa ttttcctttg tttcgggtgc gcttcgcggt
    10441 ttgaacgaga catcttttct ctttcaaacc gtcaaatttt acgaaacatt tttagaagtt
    10501 gagaacgaac gaatgtgttt caaaaaacgt tcgtcttttg aaacagcatt ttttgagttt
    10561 ttttcgatga aaaaatgaat attgtaaagt tgctgagcag agaacttttt ttgctctata
    10621 tgtgtttgaa aatcaacaat ataaaatctt tgataaaatt ttatccacta aatattttgt
    10681 acattaaaac agactcctta cctttgttca atcaaacgaa cgttttttga aacaacacct
    10741 atatcttaag ataaataact aataacaaga tccttacact tcaagatttt ccctttaaac
    10801 taaaaaaact ccggtattct tttatattta tattttttta tacaaacttt gtcctttcat
    10861 aaattcattt aataactaac attatggaag aaaaaaagta gttatctcat tgaatgataa
    10921 cttagtaacc atcgaagtaa atggaaaagt aatctttgcg ggtaaagccg acttgcaatt
    10981 cagcctcaat caaaaggtta gagaaccact acgcatcaca aaaggcaaag gaaagctaat
    11041 ggaggcactt accgaaagct ttatcaaagg cggaatcaac agcatggaaa acagacccat
    11101 tgaagaacta caggaaacaa taaaagaata tctcaccttt gaatatcagc gcaaaggcat
    11161 tgctacagag cccaataaac gttcttttct atcagagctg aaaaaatatg ccagagcatt
    11221 ccggaaaaag cgagatgaaa gcgaataacc gattgttaaa atcctgtaaa agcccctttc
    11281 taaagtactt ttacaggatt agtctattca aaacttatta ccgtactttg ccatgggtaa
    11341 aaataaaagc ccgacaataa ctcattaata aacttaaaaa aatcaattat gaaaaagaac
    11401 aggaaagcag tatcgaaaaa cgaaatgatg aaaggaaaat ggaaaagaca aatcatgctc
    11461 gaaaaggact acacagaaca gtgctccgaa tggatggcag aacgactgga agccctcata
    11521 gaatatatgc aatatggaca tgcagccgta gcttatatga aacaggacgg aacattcaaa
    11581 ctggtgaaag gaacattggt gggatacgaa aaagatttcg gaaagcagta tgatccgatg
    11641 gaaataaaaa acacagtggt ctaccgggat gtggagcaac aaaggtggat gaccttcaaa
    11701 atagagaatt tcatggaatg gagagcgatc gtataggaga atctttcagt gaccaattaa
    11761 tcagtaacat aacaacttaa caattatggc aacaacatac gatggaataa attactttcc
    11821 gatagctgtg aattttatgg aagagaacgc aatggaggta atagaagcaa aatatggcat
    11881 gaaaggactc gcgattgtac tgaaactcct atgcaaaata tataaagaag gatattatat
    11941 tccgtggggt gaggaacaat gccttatttt cgccaacaag acgggaaaag aggcagacgc
    12001 agaagaggtg caggggatta tcgagataat gatcgagaaa ggaatgatag acaggggaag
    12061 ctatgcggaa cataaagtac tgacctctga agcaatacaa aaagtatgga tagaggcaac
    12121 caagcgaaga aagaggaact ggacagccat gccttatcta ctgataaaac cgaaagagac
    12181 atgtaatgaa gaaaagaccg tctgcacgca aaatgtagag caggatgcag gctctgatgc
    12241 aaaaaatgca tgcaataccg aacaaagtaa agtaaagcaa agtagagaat ttcccccctc
    12301 agctccccca agggggaagg aagaggaagt caatgctacg ccggtcagta tgcccggata
    12361 cgcatttaat acaatgacac acaactacgt gggattaatg ggaaacctgg aacgattcgg
    12421 aataacagac gaaaaagaga tcgaagcaat cctgcgactg tcagattacg ggagaaaagg
    12481 aacccctgta tggaaactga tttgcagcac gaactggagt aacatcggag caaaaggaaa
    12541 atacatgatc gcagcgttga accgggcaaa gaaaagaagc ggaacctaaa aaagaatttt
    12601 tctgacaaac agtacatttt atattctgga aaatgctatt tgcttgcaat caattaaaga
    12661 acgcagctgt tttcctccgg aaacgggcac tgattctcaa gggattgaaa agcgattcaa
    12721 aaagcactaa tacgaagtta aaatcgtgac ttcaggaagt taacttcccg aagatacgat
    12781 tttaacttcg taaaattatg atattaactt cgtaaacaac aagatgttaa cttcgtaaac
    12841 ggcatcatcc ggacatcaaa gcaatcaaaa aagattgtca gactatagta tttcaggcag
    12901 ttgccagact tgtatgtgac gaatcccttc tttggagggc aatgtggtat cgtccataga
    12961 aacgacccac ttttcataat tgtcttgtat catctccagc gtgttgtaca tttgctccac
    13021 ttgaaaatca tcattgagca gaggtgcaca ttgcaaatac acaatgcggt ctttcttcct
    13081 g
//
