LOCUS       gnlProkkaNCIDLHPG_60   12937 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NCIDLHPG_60.
ACCESSION   gnlProkkaNCIDLHPG_60
VERSION     gnlProkkaNCIDLHPG_60
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 13:40:31
            Original ID  :: gnl|Prokka|NCIDLHPG_60
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12937
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12937
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2748:10631]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2749..10631
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..12937
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12937
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             complement(208..1116)
                     /NRPS_PKS="Domain: PKS_ER (2-209). E-value: 3.2e-12. Score:
                     38.0. Matches aSDomain: nrpspksdomains_ctg35_1_PKS_ER.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 198.5; E-value:
                     2.2e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_1"
                     /sec_met_domain="ADH_N (E-value: 5e-12, bitscore: 35.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.9e-22, bitscore:
                     69.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGY
                     ATDSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPAEACMLSDMIPTGLHA
                     SEMAGVTFGDDVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIID
                     YHNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSIGNVNYLNGHDDVV
                     FNAGDWGVGMGHKTIHGGLMPGGRLRMEKLAVLVVNGRIDPSLMITHRFEGFEKIPDAI
                     ELMHHKSADLIKPVVICNDID"
     aSDomain        complement(490..1110)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg35_1_PKS_ER.1"
                     /evalue="3.20E-12"
                     /label="ctg35_1_PKS_ER.1"
                     /locus_tag="ctg35_1"
                     /protein_end="209"
                     /protein_start="2"
                     /score="38.0"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGYAT
                     DSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPAEACMLSDMIPTGLHASE
                     MAGVTFGDDVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIIDYH
                     NGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSI"
     CDS_motif       complement(685..711)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg35_1_0002"
                     /evalue="5.30E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg35_1"
                     /protein_end="144"
                     /protein_start="135"
                     /score="0.9"
                     /tool="antismash"
                     /translation="GAGRVFAVG"
     CDS_motif       complement(1072..1110)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg35_1_0001"
                     /evalue="6.00E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg35_1"
                     /protein_end="15"
                     /protein_start="2"
                     /score="9.7"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVG"
     CDS             complement(1131..1277)
                     /locus_tag="ctg35_2"
                     /transl_table=11
                     /translation="MKGFAMLGPNKTGFIEKEDPKVGSRDALVRPLAVAPCTSDIHTVF
                     EDA"
     CDS             complement(1508..2698)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 230.9; E-value: 3.3e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg35_3"
                     /transl_table=11
                     /translation="MDAKPNRRALSLGSFVILYLGYMLLFADRTVLNLSLAAIGKDFSV
                     SPAALGATSSVFFLGYTIMQIPGGWLTDRFSSRKVIIATLAFWSVMTIFTGLAWSLAAL
                     LVIRFLFGIAEGPYPPAAMKQVAQDFPVNKRAQLTAALISSNYAGAALAPFIIVPIIAA
                     TGWRSAFFWLGGFGLLLMVSYLFFRGHGGGQTVTKQERQKINWKEIDPRVWAFVVIGLA
                     LNIITKGMETWMPVYFLNARHINLANLAWLVPLPTIAGGIAALISGYVMVHIFKNHERL
                     MIILASFLTVLTMFGLYKSTSLVWLVIFQMATYFVKSLAFTGIFSYAAQLFPQKTYGSQ
                     IGTINFGGQLGGFFGPLLIGWIVQLSGSYDTAFFGLVISALVAGVASLFIGNLKAK"
     CDS             complement(2749..4173)
                     /NRPS_PKS="Domain: AMP-binding (8-379). E-value: 2.4e-71.
                     Score: 232.3. Matches aSDomain:
                     nrpspksdomains_ctg35_4_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     307.2; E-value: 2.9e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_4"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-76, bitscore:
                     245.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIPNWLLKQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQA
                     QTDQPRVGVMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDD
                     QLADRYYGGHRVLCSELTAGTAPAAVLTPTVDLDAVASIMYTSGTTGQPKGVLQTYGNH
                     LASAISSSLNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQIL
                     EDEPVTIISAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPIV
                     QCYGMTETCSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQ
                     PAKFAAKHDGDWYRTGDVGHFDEDGFLYVDGRLDEMIISGGENIFPAEVENVLRQYPGI
                     QEIAVVGRNDQQWGAVPVAVVVSKQPVDFQQLEAFGREHLAHYKVPKVYLQTDALPKNA
                     SGKVQKFRLQDLVANA"
     aSDomain        complement(3037..4149)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg35_4_AMP-binding.1"
                     /evalue="2.40E-71"
                     /label="ctg35_4_AMP-binding.1"
                     /locus_tag="ctg35_4"
                     /protein_end="379"
                     /protein_start="8"
                     /score="232.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQAQTDQPRVG
                     VMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDDQLADRYYG
                     GHRVLCSELTAGTAPAAVLTPTVDLDAVASIMYTSGTTGQPKGVLQTYGNHLASAISSS
                     LNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQILEDEPVTII
                     SAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPIVQCYGMTET
                     CSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQPAKFAAKH
                     DGDWYRTGDVGHFDEDGFLYVDGRLDEMIIS"
     CDS_motif       complement(3703..3753)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg35_4_0001"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg35_4"
                     /protein_end="157"
                     /protein_start="140"
                     /score="22.4"
                     /tool="antismash"
                     /translation="ASIMYTSGTTGQPKGVL"
     CDS             complement(4183..5004)
                     /NRPS_PKS="Domain: ECH (18-261). E-value: 4.2e-63. Score:
                     204.7. Matches aSDomain: nrpspksdomains_ctg35_5_ECH.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 197.1; E-value:
                     4.6e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_5"
                     /transl_table=11
                     /translation="MTSANWTPVKEYSEIIFERDDKIAKITMNRPEKHNAFTPVTVAEM
                     INAFNICRDDSTIGVIILTGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIR
                     IIPKPVIAMVKGWSVGGGNVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVI
                     GHKRAKEVWFLNHFYTADEAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKA
                     AMNADTDGLAGLQQFAGDATMLYYTTDEGKEGRDAFNQKRDPDFDKFPKFP"
     aSDomain        complement(4222..4950)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg35_5_ECH.1"
                     /evalue="4.20E-63"
                     /label="ctg35_5_ECH.1"
                     /locus_tag="ctg35_5"
                     /protein_end="261"
                     /protein_start="18"
                     /score="204.7"
                     /tool="antismash"
                     /translation="RDDKIAKITMNRPEKHNAFTPVTVAEMINAFNICRDDSTIGVIIL
                     TGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIRIIPKPVIAMVKGWSVGGG
                     NVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVIGHKRAKEVWFLNHFYTAD
                     EAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKAAMNADTDGLAGLQQFAGD
                     ATMLYYTTDEGKEGRDAFNQK"
     CDS             5039..5422
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144:thioesterase superfamily protein (Score: 100.2;
                     E-value: 1.1e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_6"
                     /transl_table=11
                     /translation="MNLLENLGIHQDLVTKDRVELSMPVQAKHLQPYGIVHGGINTVLA
                     ETAASLGANANVAPGRIAVGVNVTTQHIRAIREGEIFVVATPDHVGRTLQTWQARLLVN
                     DRLTATATITLMNVPAPTNNHKH"
     CDS             complement(5831..6208)
                     /locus_tag="ctg35_7"
                     /transl_table=11
                     /translation="MTNDINFWTGIKDPYLKPDKPFLTEDKELKIIHLIQSYPMHCPLC
                     GQLMRRNGFRKRPVTIKILTPAGKPAVLKIKKQQYLCPPSPQCPKRVTKVAEIQGVNFA
                     CRIANVVKYHIVQELSESVRN"
     CDS             complement(6421..7179)
                     /locus_tag="ctg35_8"
                     /transl_table=11
                     /translation="MMYEFPRLTAHHIQTTDQPVVTSTNEMAKERLKVKDQPFLISARQ
                     QTAGHGKTSRKFYSPAGSGAYFTLALPFSYLAKSAGQVTVTAAVAAYEVLSKQFTVPIT
                     IKWVNDLYCERKKVVGILAEMEMTANNQPRGIVVGWGINLAAPTAPLPPALQLRAGWLG
                     TTSIDDHQRLQIVDAVAAHFLDLLANASWKHILQVYQAHQYLINKLLLVDTGAERVRGY
                     FDHITDDGWLCVQTDNGPRAFMTGTVRELV"
     CDS             complement(7194..10631)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     92; E-value: 5.7e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_9"
                     /sec_met_domain="ATP-grasp (E-value: 8.4e-12, bitscore:
                     34.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2e-11, bitscore:
                     33.3, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-36, bitscore:
                     116.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKKVLVANRGEIATRIIRACHELGIKAVAVYAKEDEYSAHRFAA
                     DEAYQIGAGEHPLDAYLDIDEVIRVAKESGAEAVHPGYGFLAENADLAQACIDNGLKFI
                     GPKPEHLRMFGDKLVAKRVAVEAGLQPIPGLSGDVKNVDQVKDFAHQYGYPIMVKAANG
                     GGGRGMRIINDDQQLTDEFDQAKDEALKAFGSDEMYVEKDVQHPKHIEVQVIADEHGHV
                     MHLFERDCSVQRRHQKVIEFALSVVLTPERRVEVCGLAVKLMKSVHYQNAATIEFLATP
                     DHFYFIEVNPRVQVEHTVTELITGIDIVKTQIRVAAGEDLHQDIGLPQQDDLKFHGAAI
                     QCRVTTEDPENNFMPDTGQVTTYDAPGGTGVRLDGNVYPGYKVTPYFDSLLVKCCTRGE
                     DFSDARIKMLRALEEFKIRGVKTNIPFMINVLKHPTFIAGKCSTTFIDENPDLFSFAHR
                     PDTPNQLLQYIGNVTVNGFAGVTKRTKLVLPDMQEPQAGQLTPNQHTTKTAKDILDKQG
                     ADAAMQYVKDQPRVLLTDTTMRDAHQSLFATRMRTHDMLPAMKVYDRAMPNLFSVESWG
                     GATFDVCYRFLGEDPWTRLRLLKKYMPHTLQQMLLRASNAVGYQNYPDNELKRFIEHSA
                     ATGVDVFRIFDSLNWIDQMERSITYVRETGKIAEGTMCFTGDFLSPHEHKYTLDYYMKL
                     AQSLVDAGAQIIGIKDMAGLLKPKAAYELVGSLKAKFDVPVHLHTHDTTGNGVPTYVAA
                     TNAGVDVVDVAMSSMAGTTSQPSLATFYYALEGDKRQPDLNMHNVAVLNRYWSNVRPLY
                     NDFSNGVNAPQPDLYQTEMPGGQYSNLKQQAQSLGINDFSLVEEKYREVNQLLGDIIKV
                     TPSSKVVGDMAIFMIQNHLDKDNILTKGQRVDFPESVVNFFAGDLGQPYRGFPKDLQKV
                     VLKDHPAITVRPGSLAKPVDFAAVKQELAAKINQEPSEDDLQGYIMYPKVFTTYFRNHQ
                     RYGEVMDLDTTTYYQGMRPGEILHVKYGQGKEMIIKLDFVSAPDDDGDRFLFFELDRRI
                     LKIKVKDNSMKDKVVSVSKADPDKSNEIGMPLNGNVVKVNVAEGDQVKVGDVLVVTEAM
                     KMESAVKAPFTGKVTKVYAKVGDALKSQDLLLTLTEDA"
     CDS             11332..12276
                     /locus_tag="ctg35_10"
                     /transl_table=11
                     /translation="MTRKVAVVGMGHVGATVAHYLVAGGFTDDLALYDTNEAKVRADAL
                     DLRDAMANLPFHTNLTVNDDSQLADCDVVISTLGKSKLVDTPDHDRFAEFKFTRTQVPL
                     VAKKLVDNGFHGKLVDVTNPCDVITSMYQKLTGLPKNHVMGTGTLLDSARMRACVGEAL
                     HVDSRSVVGFNLGEHGNSQFTAWSTVRVLGKRVLDLVDERHLDLTDMEERARQGGYMVY
                     KGKKYTNYGVATAAVRLTNALLSDARTEMPVSNYREEYGTYLSYPAVVGRDGVVEQLHL
                     DLTAAEKEKLATSAKYIKDRLSAEEQRAAQQDA"
     CDS             12643..12936
                     /locus_tag="ctg35_11"
                     /transl_table=11
                     /translation="MVIDTHTEIYDLLREYERTCVTITFKDGTSKKIFFLDVDDEYQEN
                     DVRPEKDCIVYNITDSISYGNGIPLDKLRSSPKCWCKLNSANLSFHKLKHTGF"
ORIGIN
        1 tgcaaattgt gattcaaaca ctcatcagaa gggtgcttgc tcacaagcta ctgactttag
       61 tcagtggtgg ttgactttgc gtatgttaga tagaaaacgt ggtcaataac cacaggccta
      121 gtgtctaagc cggccgaaga acgatgcgtt ccgcccctag cttagtcata cgacctgcca
      181 agcaagttat ttgccactcc cttttaatta gtcgatatcg ttgcaaatta cgaccggctt
      241 gattaagtcc gccgacttgt ggtgcatcag ttcgatggcg tccggaatct tctcgaagcc
      301 ttcgaagcga tgggtgatca ttagtgatgg atcgatccgg ccgttcacca cgaggacggc
      361 cagcttttcc atccgcaggc ggccaccagg catcaggcca ccgtggatgg tcttgtgacc
      421 catcccaaca ccccagtcac cggcgttgaa gaccacgtcg tcgtgaccgt ttaagtagtt
      481 aacgttcccg attgagccac ccggcttgag catccggacg gcttcttcaa aggtgtcctt
      541 ggcgttccca ccggcgatca ggaccttgtc gaccccttgg ccaccagtgg cttccaggat
      601 ttggtcggaa atccggccgt tgtggtagtc aatgatgtcg gttgcgccgt actttttagc
      661 cacttcgacc gtcttttccc gtgaaccaac cgcaaagacg cggccagccc cgtggagcac
      721 cgccccgcgc agggccatca agccaaccgg gccgatccca atcacggcga cgtcatcccc
      781 aaaggtcacg cccgccattt cggaagcgtg gaggccagtt gggatcatgt cggaaagcat
      841 gcaggcctcg gccgggtcaa tttcatccgg taggtgagcc aggttcccgt cggcgtcgtt
      901 aacgtggaaa cgagtggcga agaccccgtc cttgatatta gagaacttcc agccgcccag
      961 catcccgtcg gaatcagtgg cgtagccagc ttgggagtaa acgtcagacc agtttggcgt
     1021 gatcgccgga acgagtaccc ggtcacccgg tttaaagtcc ttgacgtctt caccgacttc
     1081 cacaaccacc ccgcaggctt cgtggccgag aatcatattc tcccgtggcc ctaggcatct
     1141 tcaaacacgg tgtggatgtc agaagtacac ggggcaacgg ctaggggacg taccagggcg
     1201 tcacggctgc ccaccttggg atcttctttt tcaataaagc ccgtcttgtt ggggcccagc
     1261 attgcaaaac ctttcattca taactaccac ctttcttgat tagttgccgt cattctaaca
     1321 taaatcatgt tataaccaag tcttcatatg tgagtttaat taattttaaa gaaagcgtcc
     1381 acattctctg aaagggttaa aataacaggg attatgatag ttaagaaatt gatttgaaat
     1441 aaataaaatg actgtgataa tcccgtacga ggtcaccaca gtcattaatc attctataat
     1501 tagcggatta tttagctttt aaattcccaa tgaagaggga cgccaccccg gccaccaagg
     1561 cggagatgac caggccgaag aaggccgtgt cgtatgaacc gctcaactga acgatccagc
     1621 cgattaagag gggaccgaag aagcccccga gttggccacc aaagttaatc gtcccgatct
     1681 gggagccata agtcttttgc gggaagagtt gggccgcgta ggagaagatc ccggtgaagg
     1741 ctagcgactt gacgaagtag gtggccattt ggaagatcac taaccaaacc aggctggtgg
     1801 acttgtagag tccaaacatg gtcaggaccg ttaaaaagga ggccaggata atcatcaggc
     1861 gttcgtgatt tttaaagatg tgcaccatta cgtaaccgga aatcaaggcc gcaatccccc
     1921 cggcaatcgt cggtagggga actaaccaag ccaagttggc taagttgatg tggcgggcgt
     1981 ttaagaagta aaccggcatc caggtttcca tccccttggt gataatgttt aaggccagcc
     2041 cgatcaccac gaaggcccag acccgcgggt cgatttcctt ccagtttatc ttttgccgtt
     2101 cttgtttcgt taccgtttgt ccaccgccgt gaccgcggaa gaagaggtag ctgaccatca
     2161 agagtaggcc aaagcccccc aaccagaaga aggccgagcg ccaaccggta gcggcgatga
     2221 ttggcacgat gatgaaaggg gccagggccg cgccggcgta gttagaggaa attaaggcgg
     2281 cggtcagttg ggcacgcttg ttgaccggga agtcctgggc gacttgcttc atggcggccg
     2341 gtgggtaagg gccctcggcg atcccaaaca ggaaccgaat taccaagagg gcggctaagg
     2401 accaggccag cccggtaaag atcgtcatca ccgaccaaaa ggcgagggtg gcgatgatca
     2461 ccttacggga agagaagcgg tcggtcagcc agccccccgg gatttgcatg atcgtgtagc
     2521 ccaagaagaa gacggaacta gtcgccccca gtgcggccgg gctaacggag aaatccttgc
     2581 cgatcgcggc caacgataag ttaagcacgg tccggtcggc gaataagagc atgtaaccaa
     2641 ggtataaaat cacaaaggaa ccgagcgaca gcgcccggcg gttgggtttt gcatccatca
     2701 tttatttgta tctttctttt ctcaattgat tattctgttg tggcatgact aagcgttagc
     2761 gaccaggtct tgtaagcgaa acttttggac cttgccgctg gcgtttttcg gtagggcgtc
     2821 tgtttgcaag tagaccttgg gtaccttata gtgggccagg tgttcacgcc cgaaggcctc
     2881 caactgctga aagtcgacgg gttgtttgct gacgaccacg gccacgggaa cggcgcccca
     2941 ctgttgatca ttacggccga ccacggcaat ttcttggatg cctgggtact ggcgcaagac
     3001 gttttccacc tcggcgggga aaatgttttc gcccccggag atgatcattt catctaaccg
     3061 tccgtcgacg tacaagaaac cgtcttcatc aaagtggccg acgtcgccgg ttcggtacca
     3121 gtcgccatcg tgcttagccg caaacttggc cggttggttt aagtaacccg gggttaaggc
     3181 cggggtctgg atctcgattt cgtgatgctc acccaccaaa cgcagctggg tggtaaacag
     3241 gggcttaccg accgaaccaa ggtggtaagg cgcctcttca gccgagaggg caacgaactg
     3301 cgagcaagtt tcggtcatcc cgtaacactg gacaatcggc agcccacttt cttcgcaggc
     3361 gttaagggtc gcccggtcaa tcgtcccacc gccgagtagc accaggcgaa aggccgatga
     3421 gtaacagtgg tcatttgctt ggacgtcttc gagcatcttc tttagcatgt agggaacggc
     3481 cgaaatgatc gtaaccggtt cgtcctccag gatttggttg accacttgcg catcgaaatg
     3541 gttgactagg cgaacgccca tcccgtaaat caggccccgc attagaattg aaaagcccga
     3601 aatgtggaag atgggggcga cgcacaacca gaggtcgttt ggcaacaccc cgaggttcaa
     3661 agatgacgaa atggcggagg ccaagtggtt gccgtaggtt tgcaagacgc cctttggctg
     3721 accggtggtt cccgaggtgt acatgatcga ggccacggcg tctaggtcaa ccgtcggcgt
     3781 caacactgcc gccggggcag tgccggctgt caattccgaa cagaggaccc ggtgcccacc
     3841 gtaatagcgg tcggctagtt ggtcatcgac taagactagg tcgagccccg cgtcgccgat
     3901 ttggcggctc agttcttcag gggcaaggcg ccaatttagc caaacgatgg tcttgtcggc
     3961 ggctaagacc cccagggcgg ctaagtaacc agccaggtta ttgtgggtca tcaccccaac
     4021 ccggggctgg tccgtctgcg cttgaatctg gccagcacgg tgggcgacca ggggaaccag
     4081 ctgggcaaag gtgtaggcgg tggtaccgtc gttaaccgcc acccggttag ggtttagcga
     4141 agcctgtttg aggagccaat ttggaatctc catgacggcc tcctacggga acttcgggaa
     4201 cttatcgaag tcggggtcgc gcttttggtt aaaggcgtcg cgcccttcct ttccttcgtc
     4261 agtcgtgtag taaagcatcg tggcgtcacc ggcaaattgt tgaagccccg ctaaaccatc
     4321 tgtatcggcg ttcatggccg ccttaatgaa gcgaagggcg gtcggtgact tctttaagat
     4381 ttcatgacac cagtctaaag taactgattc gacctcagct aggggcgcca ccttgttaat
     4441 ccagttcatt tggtaagctt cgtcagccgt gtagaagtgg tttaagaacc aaacttcctt
     4501 ggcccgcttg tggccgatca cccgggctag gtaacccgag ccataaccgg cgtcaaagga
     4561 acccaccttc ggccccgttt gcccaaacat ggcgttatcg gcggcgatcg tcaggtcaca
     4621 aaccagttgt aagacgttcc cgcccccgac tgaccagccc ttgaccatgg caatcaccgg
     4681 cttggggatg atccgaatca agtgttggag gtccaaaacg ttgagccggg cgatgtggtc
     4741 ggggcccacg taacccccgt taccccgcac ggattggtca ccaccggaag aaaaggcctt
     4801 atcgccggct ccggtaagaa taatcacgcc aattgtgcta tcatcacgac agatgttaaa
     4861 cgcgttgatc atttcggcga ccgttaccgg ggtgaaggca ttgtgctttt ccggccggtt
     4921 cattgtaatc ttggcaatct tatcgtcgcg ttcaaaaata atttcggaat actccttaac
     4981 gggggtccag ttagcactcg tcataacaaa ctcctttaca aaatccagag gtacaaaaat
     5041 gaatttactt gaaaacttag gcattcacca ggacttggtg accaaagacc gcgttgaact
     5101 ctccatgccg gtccaagcaa agcacttgca accgtacggg atcgttcacg gcggaattaa
     5161 caccgtgctg gcggaaaccg cggcctccct aggggctaac gccaacgtag cgccggggcg
     5221 aatcgcggtc ggggtcaatg ttaccacaca acatatccgt gcgatacggg aaggggagat
     5281 ttttgtggtt gcaacccctg atcacgttgg tcgcacactt cagacctggc aagcccggct
     5341 actggttaac gaccgattaa cggctaccgc aaccatcacc ctgatgaacg tcccagcacc
     5401 aaccaacaat cataaacatt aattcacaaa ttggctacta ttatgcttag aaagttgccg
     5461 ggtgaccatt gggggattac ctaaatcaca ttttttaatt ttatattatg taaatcaatc
     5521 gagaagtcgt cggctaactg ttatgaaagg ggcgccacta cgcagtcgat ttaagttggc
     5581 cccgattttg tattagtgtt gcaaccagta cgcaaaagca cacataattt atcgagggga
     5641 ggaccagata tgaggaaatg gtgggtggaa ttgaaactgg tcgtcttttg catcgccgct
     5701 cttttcaggt aattactcta acggcgctaa ttagacttac ttctgtaaat ttacattatg
     5761 taaagatatc gtttgatgat taaagaagcc tcaaaggccc tccgaggatg acaatacaga
     5821 tgttcaagac ttaattacgt acgctctcac tgagttcctg aacaatatgg tatttaacga
     5881 cattcgcaat tcgacaggca aaattaactc cttgaatctc ggcaaccttg gtaactcgct
     5941 tggggcattg gggcgatggt ggacagagat actgttgttt cttgattttt aagacagctg
     6001 gttttccagc cggtgtaagg attttgatcg ttacgggccg cttacggaag ccattacgac
     6061 gcatcaactg gccgcaaagc ggacagtgca tgggataaga ctgaattaaa tggataatct
     6121 ttagttcttt atcttcagtt aaaaatggtt tgtcaggttt taagtaagga tccttgattc
     6181 cagtccaaaa attgatatca ttagtcatga ggaatatatc ctttctaaga caactgagtg
     6241 gttatgggga taacttaaga cagttgtctt tttttatttt taaatcaatg gtacagcaag
     6301 taacaaaaaa cggtaaagac aagaaatcat cttatcctta ccgaatatca tagaaccttc
     6361 aaggataact gcggtcaaaa cacgtccgcg tttgtccaag aaggactgct tttttaatta
     6421 ctaaaccagt tcccgaaccg tccccgtcat gaatgcgcgg ggcccgttat ctgtctgcac
     6481 acataaccag ccatcatccg taatatggtc aaagtatccc ctaacacgtt ccgctcctgt
     6541 atcaacgagg agcagcttgt taataaggta ttgatgagcc tggtaaacct gcaggatgtg
     6601 tttccaggac gcgtttgcta acaggtcaag gaagtgcgca gcgactgcat caacgatttg
     6661 tagccgttga tggtcatcaa ttgaggtggt gccgagccat cccgcacgta actgaagtgc
     6721 tggcggcaag ggagcagttg gtgccgccag gttaatcccc cagccgacca ctattccccg
     6781 cggctgatta ttcgcggtca tttccatttc agcaagaatc cccaccacct tctttcgctc
     6841 acagtacagg tcgttcaccc atttaatagt aatgggaaca gtgaattgct tgctgaggac
     6901 ttcataagca gcgaccgcgg cagtcaccgt tacctgacca gcactttttg ccaggtagct
     6961 aaagggtaag gcaagggtga agtaggcccc acttcccgcg ggtgaataaa acttccggct
     7021 ggtctttccg tggcctgccg tttgctgccg ggcggagatg agaaagggct gatctttcac
     7081 ctttaaccgt tcctttgcca tttcgttagt cgaagtgacc actggctgat cggttgtctg
     7141 gatatgatgt gctgtcagtc taggaaattc gtacatcatt gctactctcc ttatcaagca
     7201 tcctcagtca atgttagtaa gaggtcctga ctctttaacg catcgccaac cttagcgtat
     7261 actttcgtca ccttaccagt aaatggcgct ttaactgctg attccatctt catcgcctca
     7321 gtaacaacca gaacgtcacc aaccttgacc tggtcacctt ctgctacgtt aaccttgacc
     7381 acgttcccgt tcaacggcat cccgatctca ttactcttat cgggatcagc ctttgaaaca
     7441 ctgacaacct tgtccttcat gctattgtcc ttaactttta ttttaaggat ccgcctgtcc
     7501 agttcaaaga agaggaagcg atcaccgtca tcatctggtg ctgaaacaaa gtcgagtttt
     7561 ataatcattt cttttccctg accatactta acatgcaaaa tttcaccagg acgcatacct
     7621 tgatagtagg tcgtggtatc aaggtccatc acttcaccgt accgctgatg gttgcggaag
     7681 taagtggtaa agactttcgg atacatgatg taaccctgca ggtcgtcctc gctcggttcc
     7741 tggttgatct ttgcggccag ttcctgctta acggcggcaa aatcaaccgg tttagcaagg
     7801 ctcccgggcc gaaccgtgat tgcaggatgg tccttcaaga caaccttctg taggtccttg
     7861 gggaagcccc tatatggttg accaaggtcg ccagcaaaga agttaaccac tgattctgga
     7921 aagtcgactc gttgcccctt tgtcaggata ttgtctttat caaggtggtt ttggatcatg
     7981 aagattgcca tgtcgccaac caccttcgag cttggcgtca ccttgatgat gtcaccgagc
     8041 aactgattga cctcccggta tttttcttcc accaggctaa aatcattgat tcctagtgac
     8101 tgggcctgtt gcttcaggtt cgagtactgg ccacctggca tttccgtctg gtataggtct
     8161 ggttgcggtg cgttgacccc gttgctgaag tcgttgtaaa gcggccggac attggaccag
     8221 taccggttta agaccgccac gttatgcata ttaaggtccg gttggcgttt atctccttct
     8281 agcgcgtagt aaaaggtggc taaactaggc tgactggttg tccccgccat tgaagacatc
     8341 gccacgtcca ccacgtcaac acccgcattt gtggcggcaa cgtaggttgg aactccatta
     8401 cccgttgtgt catgagtgtg gaggtgaaca ggaacatcaa acttagcctt caaactaccg
     8461 actagttcgt aagcggcctt tggtttcaag aggccggcca tatccttaat accaataatc
     8521 tgcgctcccg cgtcgactaa tgactgtgcc aacttcatgt aataatctag ggtgtacttg
     8581 tgctcgtgag gactaaggaa gtcgccggta aagcacattg ttccttcggc gattttgccg
     8641 gtttcccgaa catatgtaat gctacgttcc atctggtcaa tccagttgag ggagtcaaag
     8701 atccggaaaa catccacccc ggttgcggca ctgtgctcaa tgaaccgctt cagttcatta
     8761 tccggataat tctggtaacc gaccgcgttc gacgcccgca acaacatctg ctggagagta
     8821 tgtggcatgt acttcttcaa taatcgtaat cgggtccacg ggtcttcacc aaggaaccgg
     8881 tagcacacgt caaaggttgc cccgccccag ctttcaacag aaaagaggtt aggcatcgcc
     8941 cggtcgtaaa ccttcattgc gggcaacata tcgtgcgtcc gcatccgagt ggcaaaaagg
     9001 ctttggtgag catcacgcat tgtggtatca gtcagtagta ccctcggctg gtccttaaca
     9061 tactgcatcg ccgcatcggc tccctgttta tccaggatgt cctttgctgt ttttgttgta
     9121 tgctggttag gtgtaagttg gcctgcttgt ggttcttgca tgtcaggcaa aacaagtttg
     9181 gtccgcttgg ttacccctgc aaagccattg acggtaacat tgccaatata ttggagcaac
     9241 tggttaggcg tatcgggccg gtgcgcaaag ctaaagaggt cgggattctc gtcgataaac
     9301 gttgtcgagc attttccggc aataaacgtg ggatgcttta acacgttgat catgaaggga
     9361 atattagttt tgactccccg aatcttgaat tcttcaagcg cccgcagcat cttaatccgg
     9421 gcatcactga agtcttcacc ccgggtacaa cacttaacga gcaaggaatc aaagtaagga
     9481 gtgaccttat agccgggata gacgttcccg tcaagccgga caccggttcc ccctggcgca
     9541 tcataggtcg taacctgtcc cgtatctggc ataaagttat tctcgggatc ttctgttgtg
     9601 acccggcact gaatggctgc cccgtggaac ttgagatcgt cttgctgggg aaggccaata
     9661 tcttgatgaa gatcttcacc ggccgcaacc cgaatctggg tcttaacaat atcaatccca
     9721 gtaatcaact cggtaacggt gtgttcaacc tgcacccggg gattaacctc aatgaagtaa
     9781 aaatgatccg gggtcgccaa gaattcgatc gtcgccgcat tctggtagtg aacactcttc
     9841 atcagcttga cggccaggcc acaaacttcg acccgccgct caggggtcaa gacaacgcta
     9901 agtgcaaatt caataacctt ctggtggcgg cgctggacag agcagtcacg ttcaaagagg
     9961 tgcatcacat gcccgtgctc atcagcaatt acctgcactt caatatgctt cgggtgttgg
    10021 acgtcctttt cgacatacat ctcatccgat ccaaacgcct tcagcgcctc atccttcgcc
    10081 tgatcaaact cgtcggtgag ttgctggtcg tcattgatga tccgcatccc ccgaccgcca
    10141 ccaccattag cagccttaac catgatcggg taaccatatt ggtgagcaaa atcctttacc
    10201 tggtcaacat ttttaacatc ccccgataaa ccgggaattg gttgcagccc tgcctcaacg
    10261 gccacacgtt tagcaaccaa cttatcccca aacatacgaa ggtgttccgg cttaggtcca
    10321 ataaacttta atccattatc aatacaggcc tgcgcaaggt cagcgttttc tgccaggaag
    10381 ccataaccag ggtgaacagc ttctgccccg ctttctttgg ccacccgaat tacttcatca
    10441 atatccaggt aagcatcaag cggatgttca ccagccccga tttggtacgc ctcatcagca
    10501 gcaaagcggt gcgcactata ctcatcctcc ttagcataaa ctgcgacggc tttgattccc
    10561 agctcatgac aggcgcgaat aatccgtgta gcaatttcac cacggttagc aactaaaact
    10621 tttttaaaca caattatcca ccatcctttt tattaatcct tcacgcccat cacgtcatta
    10681 ctattggcgg tgagggtggc tgtatttgta gaaatattaa tattaccaac cattgcactc
    10741 acctcctcat ttttctaatc aaattttaaa acaaactata atcaatctaa gctaacgtgt
    10801 caataatttt tcctcaagaa atgcccgcta tcaaacgaat ttatactata aattatctgc
    10861 ctttgcaccc atcttttctc atcttttttt aatttttatc ttgacttccc tatctgccta
    10921 gtgatatagt acttaacaat caattgaaac aagttaaaga cgttgagcga gaaacagcga
    10981 tgaggccgaa gcaagagagc tggtgggtgg tgtgaaccag tgagaggccg cacctactaa
    11041 tcactcgtga gtcgtacgcc gaacggattc cctagtagag cgtattggta gcacccatta
    11101 ccgtgccggc taataccaca ttatttgtgg cggttggttg aggcgacatt atgtcgtaaa
    11161 gaaaggtggt accacgcaca agcgtccttt ttagttctta gatttatcaa gagctagaaa
    11221 ggacgctttt tgttttgata ttaaaggtgg tggtgatcat ggcagacagt gatatttctg
    11281 acattagtaa gattaaaggc aacaatacga taatcgaaag gaagttttat tatgacaagg
    11341 aaagtagcag tagttggaat ggggcacgtt ggcgcaactg tcgcccatta tctcgttgct
    11401 ggtggattca ctgatgattt agccctctat gatactaacg aagcaaaggt ccgtgccgat
    11461 gcgcttgacc tccgtgacgc catggcgaat ctcccgttcc acacaaactt aaccgttaat
    11521 gatgattcac aattagctga ctgtgacgtt gtaatctcta ctctgggaaa gtctaagctg
    11581 gtggacacac ccgatcacga ccgctttgca gaatttaaat ttacccggac tcaggttcca
    11641 ttggtcgcta agaaactcgt tgataacggt tttcatggca aacttgtcga cgttaccaat
    11701 ccctgtgacg tcatcacttc aatgtatcag aagctcacgg ggctaccaaa gaatcacgtg
    11761 atgggtacgg ggaccctgct agactccgca cgaatgcgcg catgtgttgg ggaagccctc
    11821 catgttgact cacgatccgt ggtcggcttc aatcttggtg aacacggtaa ctcccaattt
    11881 actgcctggt caacagtccg ggttctcggc aaacgagtac tagatctggt ggatgaacgg
    11941 cacctcgacc ttaccgacat ggaagaacgc gcacggcaag gaggctacat ggtctataag
    12001 ggaaagaagt ataccaacta cggtgttgct actgccgcag tccggcttac caatgcccta
    12061 ctaagtgatg cccggactga aatgccagtt tcaaattacc gtgaagaata cggaacgtac
    12121 ctctcctacc ccgcagtcgt tggtcgtgac ggggtggtgg aacaacttca cctggacctt
    12181 accgctgctg aaaaagaaaa gctcgctacc tctgccaaat acatcaagga tcgcctttct
    12241 gcagaagaac aacgggcagc tcaacaagac gcctaacttg ctggtattaa atgatctctc
    12301 ctcaaacata tccctaataa agcaccaacc ttattctgta taactgaaac ttgaaagctg
    12361 ataaccatgt caaacaggcg aggttatcag ctttcaagtt tcagttaatt aatcaacggc
    12421 ggagccagct taaatagctg gcttttatta tgcagaaagg aggtaaaaat agctaaagtt
    12481 caaaacgaaa tggcgacccg gatcactgtt gatactgtcc aggcggctaa ttccatgcag
    12541 gcaatgcgtc aggctatctc agccaatacg aatgcatgga aggcaattaa aaatcaacca
    12601 ttctgtgaca gaatattaag tagtactggg gagtgaataa agatggtgat cgacacacat
    12661 actgaaatat atgacctcct aagggaatat gaacggactt gtgtgaccat tacgtttaaa
    12721 gacggaacgt ccaagaagat tttctttctg gatgttgacg atgaatacca agaaaatgat
    12781 gtgagacctg aaaaagattg tatcgtatac aatataacgg attcgatatc atatggtaat
    12841 ggcatcccgc tagataaact taggtcaagt ccaaaatgtt ggtgtaaatt aaattccgcg
    12901 aatttatcat ttcacaagct taagcatacc ggcttct
//
