Select genomic region:
Overview
4.1
7.1
8.1
12.1
12.2
12.3
15.1
15.2
23.1
23.2
34.1
56.1
67.1
89.1
89.2

### Identified primary metabolite regions

c00004_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_18)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 4.1 | Flavoenzyme_AA_peptides_catabolism | Putative | 40,704 | 69,105 |

c00007_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_35)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 7.1 | OD_fatty_acids,OD_unknown,porA | SCFA | 53,338 | 106,429 | Acetate to butyrate C. sporogenes | BUT | 66%

c00008_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_39)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 8.1 | OD_unknown,porA | SCFA | 20,760 | 45,476 | porA C. sporogenes | POR | 60%

c00012_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_43)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 12.1 | PFOR_II_pathway | SCFA | 17,625 | 41,155 | PFOR II pathway B. thetaiotaomicron | PFORII | 100%
Region 12.2 | TPP_AA_metabolism,Flavoenzyme_AA_peptides_catabolism,Others_HGD_unassigned | Putative | 201,831 | 234,557 |
Region 12.3 | Others_HGD_unassigned | Putative | 283,280 | 307,527 |

c00015_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_46)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 15.1 | GR_eut-pdu-related,EUT_pathway | SCFA-other | 7,189 | 47,817 | Ethanolamine degradation S. typhimurium | EUT | 47%
Region 15.2 | Rnf_complex | E-MGC | 81,104 | 103,739 | Rnf complex C. sporogenes | RNF | 83%

c00023_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_54)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 23.1 | Flavoenzyme_AA_peptides_catabolism | Putative | 122,319 | 143,916 |
Region 23.2 | Pyruvate2acetate-formate | SCFA | 177,195 | 208,961 | Pyruvate to acetate and formate C. acetobutylicum | PFL_acetate | 100%

c00034_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_65)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 34.1 | OD_unknown,porA | SCFA | 201,859 | 226,510 | porA C. sporogenes | POR | 60%

c00056_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_87)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 56.1 | OD_unknown,porA | SCFA | 166,725 | 191,405 | porA C. sporogenes | POR | 40%

c00067_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_98)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 67.1 | Putrescine2spermidine | Aliphatic_amine | 103,341 | 127,433 | Arginine2putrescine R. gnavus | PUTR | 100%

c00089_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_120)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 89.1 | Acetyl-CoA_pathway | SCFA | 23,694 | 58,812 | Acetyl-CoA pathway B. hydrogenotrophica | Acetate | 57%
Region 89.2 | succinate2propionate | SCFA | 150,038 | 165,605 | Succinate to propionate B. theta | PRO | 33%

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 4.1 | Flavoenzyme_AA_peptides_catabolism | Putative | 40,704 | 69,105 |
Region 7.1 | OD_fatty_acids,OD_unknown,porA | SCFA | 53,338 | 106,429 | Acetate to butyrate C. sporogenes | BUT | 66%
Region 8.1 | OD_unknown,porA | SCFA | 20,760 | 45,476 | porA C. sporogenes | POR | 60%
Region 12.1 | PFOR_II_pathway | SCFA | 17,625 | 41,155 | PFOR II pathway B. thetaiotaomicron | PFORII | 100%
Region 12.2 | TPP_AA_metabolism,Flavoenzyme_AA_peptides_catabolism,Others_HGD_unassigned | Putative | 201,831 | 234,557 |
Region 12.3 | Others_HGD_unassigned | Putative | 283,280 | 307,527 |
Region 15.1 | GR_eut-pdu-related,EUT_pathway | SCFA-other | 7,189 | 47,817 | Ethanolamine degradation S. typhimurium | EUT | 47%
Region 15.2 | Rnf_complex | E-MGC | 81,104 | 103,739 | Rnf complex C. sporogenes | RNF | 83%
Region 23.1 | Flavoenzyme_AA_peptides_catabolism | Putative | 122,319 | 143,916 |
Region 23.2 | Pyruvate2acetate-formate | SCFA | 177,195 | 208,961 | Pyruvate to acetate and formate C. acetobutylicum | PFL_acetate | 100%
Region 34.1 | OD_unknown,porA | SCFA | 201,859 | 226,510 | porA C. sporogenes | POR | 60%
Region 56.1 | OD_unknown,porA | SCFA | 166,725 | 191,405 | porA C. sporogenes | POR | 40%
Region 67.1 | Putrescine2spermidine | Aliphatic_amine | 103,341 | 127,433 | Arginine2putrescine R. gnavus | PUTR | 100%
Region 89.1 | Acetyl-CoA_pathway | SCFA | 23,694 | 58,812 | Acetyl-CoA pathway B. hydrogenotrophica | Acetate | 57%
Region 89.2 | succinate2propionate | SCFA | 150,038 | 165,605 | Succinate to propionate B. theta | PRO | 33%

No primary metabolite regions were found in these records:
  c00001_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_1)
  c00002_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_2)
  c00003_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_12)
  c00005_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_24)
  c00006_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_30)
  c00009_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_40)
  c00010_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_41)
  c00011_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_42)
  c00013_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_44)
  c00014_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_45)
  c00016_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_47)
  c00017_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_48)
  c00018_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_49)
  c00019_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_50)
  c00020_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_51)
  c00021_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_52)
  c00022_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_53)
  c00024_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_55)
  c00025_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_56)
  c00026_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_57)
  c00027_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_58)
  c00028_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_59)
  c00029_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_60)
  c00030_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_61)
  c00031_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_62)
  c00032_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_63)
  c00033_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_64)
  c00035_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_66)
  c00036_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_67)
  c00037_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_68)
  c00038_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_69)
  c00039_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_70)
  c00040_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_71)
  c00041_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_72)
  c00042_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_73)
  c00043_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_74)
  c00044_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_75)
  c00045_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_76)
  c00046_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_77)
  c00047_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_78)
  c00048_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_79)
  c00049_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_80)
  c00050_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_81)
  c00051_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_82)
  c00052_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_83)
  c00053_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_84)
  c00054_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_85)
  c00055_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_86)
  c00057_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_88)
  c00058_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_89)
  c00059_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_90)
  c00060_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_91)
  c00061_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_92)
  c00062_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_93)
  c00063_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_94)
  c00064_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_95)
  c00065_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_96)
  c00066_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_97)
  c00068_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_99)
  c00069_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_100)
  c00070_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_101)
  c00071_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_102)
  c00072_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_103)
  c00073_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_104)
  c00074_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_105)
  c00075_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_106)
  c00076_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_107)
  c00077_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_108)
  c00078_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_109)
  c00079_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_110)
  c00080_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_111)
  c00081_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_112)
  c00082_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_113)
  c00083_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_114)
  c00084_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_115)
  c00085_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_116)
  c00086_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_117)
  c00087_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_118)
  c00088_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_119)
  c00090_gnlPro.. (original name was: gnl|Prokka|PJKACBDO_121)

Compact view
c00004_gnlPro.. - Region 1 - Flavoenzyme_AA_peptides_catabolism
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 40,704 - 69,105 nt. (total: 28,402 nt) Show pHMM detection rules used
Flavoenzyme_AA_peptides_catabolism: ((cds(Pyr_redox_2 and Oxidored_FMN) or baiCD or baiH) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00007_gnlPro.. - Region 1 - OD_fatty_acids,OD_unknown,porA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 53,338 - 106,429 nt. (total: 53,092 nt) Show pHMM detection rules used
OD_fatty_acids: (minimum(1, [PFOR_II, POR, POR_N]) and (minimum(2, [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase, CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1, ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C, Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and not (Gly_radical_scatole or Gly_radical or Gly_430_pcre or Gly_8-9_TMA))
OD_unknown: (minimum(1, [PFOR_II, POR, POR_N]) and minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC, Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical or Gly_430_pcre or Gly_8-9_TMA))
porA: (Fer4_7 and TPP_enzyme_C and POR and POR_N and PFOR_II and not (EKR or Fer4_16))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00008_gnlPro.. - Region 1 - OD_unknown,porA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 20,760 - 45,476 nt. (total: 24,717 nt) Show pHMM detection rules used
OD_unknown: (minimum(1, [PFOR_II, POR, POR_N]) and minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC, Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical or Gly_430_pcre or Gly_8-9_TMA))
porA: (Fer4_7 and TPP_enzyme_C and POR and POR_N and PFOR_II and not (EKR or Fer4_16))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00012_gnlPro.. - Region 1 - PFOR_II_pathway
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 17,625 - 41,155 nt. (total: 23,531 nt) Show pHMM detection rules used
PFOR_II_pathway: cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00012_gnlPro.. - Region 2 - Flavoenzyme_AA_peptides_catabolism,Others_HGD_unassigned,TPP_AA_metabolism
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 201,831 - 234,557 nt. (total: 32,727 nt) Show pHMM detection rules used
TPP_AA_metabolism: (TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))
Flavoenzyme_AA_peptides_catabolism: ((cds(Pyr_redox_2 and Oxidored_FMN) or baiCD or baiH) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]))
Others_HGD_unassigned: (minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans, CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III, ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C, BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C, Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00012_gnlPro.. - Region 3 - Others_HGD_unassigned
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 283,280 - 307,527 nt. (total: 24,248 nt) Show pHMM detection rules used
Others_HGD_unassigned: (minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans, CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III, ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C, BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C, Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00015_gnlPro.. - Region 1 - EUT_pathway,GR_eut-pdu-related
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 7,189 - 47,817 nt. (total: 40,629 nt) Show pHMM detection rules used
GR_eut-pdu-related: (minimum(1, [Gly_430_pcre, Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol, PFL_acetate1, PFL_acetate2, PFL_proline, PFL_toluene]) and minimum(2, [Aldedh, EutN_CcmL, EutQ, PTAC, PduV-EutP]) and not (PFL_9_tma or Gly_8-9_TMA or NRDD) and not EutB and not EutC and not (POR or POR_N or PFOR_II))
EUT_pathway: (minimum(3, [Aldedh, BMC, Cob_adeno_trans, EutA, EutH, EutK_C, EutN_CcmL, EutQ, Fe-ADH, Fe-ADH_2, Malic_M, MreB_Mbl, PTA_PTB, PduV-EutP, malic]) and EutB and EutC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00015_gnlPro.. - Region 2 - Rnf_complex
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 81,104 - 103,739 nt. (total: 22,636 nt) Show pHMM detection rules used
Region on contig edge.
Rnf_complex: (Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00023_gnlPro.. - Region 1 - Flavoenzyme_AA_peptides_catabolism
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 122,319 - 143,916 nt. (total: 21,598 nt) Show pHMM detection rules used
Flavoenzyme_AA_peptides_catabolism: ((cds(Pyr_redox_2 and Oxidored_FMN) or baiCD or baiH) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00023_gnlPro.. - Region 2 - Pyruvate2acetate-formate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 177,195 - 208,961 nt. (total: 31,767 nt) Show pHMM detection rules used
Pyruvate2acetate-formate: ((PFL_acetate1 or PFL_acetate2) and Radical_SAM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00034_gnlPro.. - Region 1 - OD_unknown,porA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 201,859 - 226,510 nt. (total: 24,652 nt) Show pHMM detection rules used
OD_unknown: (minimum(1, [PFOR_II, POR, POR_N]) and minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC, Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical or Gly_430_pcre or Gly_8-9_TMA))
porA: (Fer4_7 and TPP_enzyme_C and POR and POR_N and PFOR_II and not (EKR or Fer4_16))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00056_gnlPro.. - Region 1 - OD_unknown,porA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 166,725 - 191,405 nt. (total: 24,681 nt) Show pHMM detection rules used
OD_unknown: (minimum(1, [PFOR_II, POR, POR_N]) and minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC, Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical or Gly_430_pcre or Gly_8-9_TMA))
porA: (Fer4_7 and TPP_enzyme_C and POR and POR_N and PFOR_II and not (EKR or Fer4_16))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00067_gnlPro.. - Region 1 - Putrescine2spermidine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 103,341 - 127,433 nt. (total: 24,093 nt) Show pHMM detection rules used
Putrescine2spermidine: (minimum(2, [AdoMet_dc, Spermine_synt_N, Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00089_gnlPro.. - Region 1 - Acetyl-CoA_pathway
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 23,694 - 58,812 nt. (total: 35,119 nt) Show pHMM detection rules used
Acetyl-CoA_pathway: (CdhC and CdhD and minimum(8, [CbiA, FTCD_C, FTHFS, FeS, Fer2, GCV_H, MTHFR, MTHFR_C, Prismane, Pterin_bind, Pyr_redox_2, Pyr_redox_dim, RACo_C_ter, THF_DHG_CYH, THF_DHG_CYH_C]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00089_gnlPro.. - Region 2 - succinate2propionate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 150,038 - 165,605 nt. (total: 15,568 nt) Show pHMM detection rules used
Region on contig edge.
succinate2propionate: (minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not Cytidylate_kin)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.