LOCUS       c00089_gnlPro..        15568 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PJKACBDO_120.
ACCESSION   c00089_gnlPro..
VERSION     c00089_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 16:40:11
            Original ID  :: gnl|Prokka|PJKACBDO_120
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 150037
            Orig. end    :: 165605
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15568
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[160037:165418]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15381
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15568
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15568
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="2"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             1355..2671
                     /locus_tag="ctg89_132"
                     /transl_table=11
                     /translation="MNKKGMIFEGLKVRNEIKKALQQEEGLPNCIQEENGYLSAEPGEH
                     AGKNVLKGERELKRVLEKLLEEDGEEICLDVTYFLVFAAAQNPVCREELKRLAPEQIIG
                     YQQMFLNNGYHGDYFLSCLGYEEHYFAQVLIGMLEKIREGSEERAEEAYHQFMGCIRKG
                     WRSARRELFTEETLDFERIQEWAGPYTEQPAMGMSQICMICLLAETCHVEIKKNVNFYL
                     ILECMIDRNTIWDSKKEEILEYEVWGRAGCADSCFYRRLEETVRNPFQAALGFRVEGYE
                     EFDCYLQNLFHLGGIDRNVLCGEELDERSRRLLLELGEFEKYSGMEKYVYSLYIVLLSG
                     YVKKCLDKIRENDPVRWQQKLDEQEREKEELKKQLTESEERFRSMKRKNSELEEKLELA
                     ERTVRRKENQLLRAAKQHQSEKQELVRLRESLYNSGRAG"
     CDS             3063..4559
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Anth_synt_I_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg89_133"
                     /sec_met_domain="Anth_synt_I_N (E-value: 1e-33, bitscore:
                     109.7, seeds: 55, tool: rule-based-clusters)"
                     /sec_met_domain="Chorismate_bind (E-value: 8.4e-97,
                     bitscore: 316.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPLFGKGGKNMTITPDCNTILKLAEEYSIVPVCREIYADVTTPIT
                     LLRKLTGLSKRYYLLESIEGGETWGRYSFLGYDPVMRVTCRDSKVYIEKQGKTEIVETE
                     KPLNVLREIMKDYKSPRLSGMPPFTGGFVGYFAYSMIGYAEPVLHIKKGTFPDYDVMLF
                     DKVIAYDHLKQKICIIVNMRTDKVMENYGEATAEIARIAGLIKSAPVPAAEAEPEQIDF
                     TCNVSREEYCSIVEKTKEYIRDGDIFQAVISRQFCSPMRGSLLNAYRVLRTTNPSPYMV
                     YLHFDEEELMSTSPETLVRLQDGRLTTFPVAGSRPRGADAEEDEALEKDLLQDEKELSE
                     HNMLVDLGRNDLGRISQFGSVEVTKYMMIHRYSKIMHICSQVEGTIRDDKDALDAVEAV
                     LPAGTLSGAPKIRACEIIEELESMERGVYGGAIGYLDFAGNLDTCIAIRMAVKKDGKVY
                     VQAGGGIVADSVPELEYEESANKAAAVMQAIKNAGEVEEL"
     CDS             4556..6160
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_trans_3N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg89_134"
                     /sec_met_domain="GATase (E-value: 4.5e-49, bitscore: 160.0,
                     seeds: 97, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_trans_3N (E-value: 1.3e-21,
                     bitscore: 69.4, seeds: 1422, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_transf_3 (E-value: 6.9e-97,
                     bitscore: 317.1, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILLIDNYDSFTYNLVQMIGTINPDIRVIRNDEMTVEEIEALHPS
                     HIILSPGPGYPKDAGICEAVIQRLQGRVPILGVCLGHQAVCEVYGARISHARHLMHGKR
                     SRVFLQTESPIFAGMEEEIDAARYHSLIAEEGTIPQCLQVLSTDVENGEIMAVGHREYP
                     VYGLQFHPESILTPQGKNILENFLNIKAVRGDKIMIKEAIHTLMDGKDLNYEMAKAVMH
                     EMMDGIATQAQMGAFLAALRMQGESIDEITAFAEVMREKGIKIKPEREVIDIVGTGGDE
                     AGTFNISTTAAFVVAAGGVPVAKHGNRSVSSKSGAADVLENLGANVALDAKQNENILNK
                     TGMCFMFAPVYHSSMKYAAPVRKEMGVRTVFNILGPLSNPAAATMQLLGVYDKNLVEPL
                     AKVLGNLGVTRGVAVCGEDGLDEITLTGETTVCEIRFGETSCYTISPEQFGMKRCELSE
                     LVGGSPADNAQITRDILSGRETGPKRDVVLLNAGMSLYLGIDGITLQEGIDMARDLIES
                     KKAQAKFDEFVKATREQ"
     CDS             6177..6974
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IGPS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg89_135"
                     /sec_met_domain="IGPS (E-value: 7.8e-87, bitscore: 283.8,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILEQIARDTEIRVTQQKKKVPLGTLKKAAYQMETDTGFPFEKAL
                     AKEGLSFICEVKKASPSKGIIAEDFPYLDIAKEYEAAGADAVSCLTEPKYFLGADSYLK
                     EIAENVKIPVLRKDFVVEEYQIYEAKALGASAVLLICALIEPVLLKRYIQVCDTLGISA
                     LVEAHDEKEISHAVWAGARVIGVNNRNLKDFSVDVGNSTRLRALAPKEILFVAESGIKG
                     PEDIARLKENEVNAVLIGETLMKSRDKKKMLSYLKGEDTSNEQ"
     CDS             6964..7599
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PRAI"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg89_136"
                     /sec_met_domain="PRAI (E-value: 2.1e-46, bitscore: 151.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSKVKICGLRRPEDIETANLYRPDFIGFVFANSSRRITEEQAEC
                     LRAGLADGILAAGVFVNAPVREAARIAEKGIIDIIQLHGDEDEAYIRSLKTFTKKPVIK
                     AVRVQSREQILEAEKLPCEYLLLDTYTKGQYGGSGKGFDLSLIPRLARPFFLAGGLSAE
                     NVQSALESSGAFAADVSSAVETEGYKDRDKVREFIRAVREQDSDTKNH"
     CDS             7622..8806
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg89_137"
                     /sec_met_domain="PALP (E-value: 1.6e-50, bitscore: 165.3,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKGRFGNYGGQYIPETLMNAVQELEEAYEKYSRDPEFNRELDDL
                     LKNYAGRPSLLYYAEKMTKDLGGAKIYLKREDLNHTGSHKINNVLGQVLLAKKMGKTRV
                     IAETGAGQHGVATATAAALMGMECEVFMGREDTDRQALNVYRMELLGAKVHPVDSGTAT
                     LKDAVNETMREWTRRMDDTLYVLGSVMGPHPFPMIVRDFQKIIGKEIKEQLQEREGRLP
                     DAVIACVGGGSNAMGAFYEFIKDEQVQLIGCEAAGLGVDTEKHAATIAKGTEGVFHGMK
                     SLFCQDEYGQIAPVYSISAGLDYPGIGPEHANLNKTGRAKYVPITDAEAVEAFEYLSKT
                     EGIIPAIESAHAVAYARKLAPTMDKDKIIVVNISGRGDKDVAAIARYRGVEIYE"
     CDS             8799..9581
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_syntA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg89_138"
                     /sec_met_domain="Trp_syntA (E-value: 2.4e-96, bitscore:
                     314.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIYQAFENKKAFIPFITGGDPTLDVTEQLLYAMEEAGADLIEI
                     GIPFSDPTAEGPVIQEANERALKAGCTTDKLFDMIKRARQKVTVPIVFLTYVNPIFTYG
                     KERFMKKCVECGVDGIIVPDMPYEEKQELAPACDAYGIDIIPLIAPTSNARITMIAKEA
                     KGYIYCVSSLGVTGVRSEIKTDIGAMVELVRRATDVPCAVGFGISTPEQAYAMAKVSDG
                     AIVGSAIVKIVAKYGKDCVPYVAEYVKEMKAAVDRANN"
     CDS             10001..11437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg89_139"
                     /sec_met_domain="CT_Vparvula (E-value: 1e-137, bitscore:
                     452.9, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTAQSLASKRIASLLDENSFVEIGSCVTARNTDFNLSEKETPS
                     DGVITGYGVIDGSLVYVYSQDASVLNGTIGEMHAKKIVRLYDLAMKTGAPVIGLVDCAG
                     LRLQEATDALNAFGEIYTKQVMASGVIPQITGIFGTCGGGLAIVPALTDFTFMEEKSGK
                     LFVNSPNALEGNEISKCDTSSAKYQSEEAGLVDVLGSEDEILAQMRQLVSMLPSNYEDN
                     SSYEDCADDLNRVCPELENCVGDTAIALSQIADNNEFFEVKAAYAKDMVTGFIRLNGAV
                     VGCVANRSEVYNDEGEKTESFDNVLSARGCKKAADFVKFCDAFEIPVLSLTNVKGYKAT
                     KCSEANIAKAAAQLTYAFTNATVPKVNIVIGEAFGSAYLAMNSKSTGADMVFAWPGAQI
                     GMMDARLAAKIMYADSDAATINEKAAEYADLQSSALSAAKRGYVDSIIEAEDTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             11452..12219
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg89_140"
                     /sec_met_domain="OAD_gamma (E-value: 1e-24, bitscore: 80.2,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQTWKKLIGLILIGVCALAMTACGSSKDSTGGLKKLDDATVDSL
                     VESFGGVVGNIADLNEESIAGLMEGDDAFSASAAIAWDGASEDLGAYVETSKGDVEIKD
                     GNYILTLACKFENRDADCVFTLDKNGNPLNVTIDPKYSMGEKMAQAGQNTLLGIGTVFV
                     MLVFLCFVISLMKYIPGFVASFDKKKTAPEEIQVPAAPAAKAIPEAAEEEVVDDGELIA
                     VIAAAIAASENTSTDSFVVRSIRKSTKRNWQRA"
     CDS             12238..12609
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.4; E-value:
                     1.8e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg89_141"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.1e-19, bitscore:
                     61.4, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGVAYDVTVEEGAGNAAAPAAAPKAAPKAAPKAAPAA
                     KPAASAAGAVAVTASVPGKVFKVEANVGQAVKAGDNIIILEAMKMEIPVVAPQDGTIAS
                     IDVAVGDSVENGDTLASMN"
     CDS             12726..13883
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg89_142"
                     /sec_met_domain="OAD_beta (E-value: 4.9e-157, bitscore:
                     515.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVTDTLSNLLHQTAFFNLTWGNYLMILVAFGFLFLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMALPYTDAAGIEHAGGLLHYFYLMDEWSILPSLIFMGVGA
                     MTDFGPLIANPKSFLLGAAAQLGIYMAYFLAIFMGFNGKAAAAISIIGGADGPTSIFLA
                     GKLGQTVLMGPIAVAAYSYMSLVPIIQPPIMKLLTTEKERKIKMEQLRPVSKLEKILFP
                     IIITVVVCLILPTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVILLGTSVGAS
                     TSAEAFLKLDTLKIVVLGLVAFAIGTAGGVLLGKLMCKLSGGKINPLIGSAGVSAVPMA
                     ARVSQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             13969..15381
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg89_143"
                     /sec_met_domain="HMGL-like (E-value: 4.7e-44, bitscore:
                     144.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.5e-57, bitscore:
                     187.7, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEVVKKPIKITETILRDAHQSLIATRMSTEQMLPIVDKLDKVGY
                     HSVECWGGATFDASLRFLKEDPWERLRKFRDGFKNTKLQMLFRGQNILGYRPYGDDVVE
                     YFVQKSIANGIDIIRIFDCLNDLRNLQTAVKASNKEKGHAQVALSYTLGDAYTMDYWVD
                     MAKRVEDMGANSICIKDMAGLLVPYEATNLVTALKAAVDIPIQLHTHYTSGVASMTYLK
                     AVEAGVDVIDTAMSPFALGTSQPATEVMVETFKGTPYDTGFDQNLLAEIADYFRPIRDE
                     ALESGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYEVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVIMGERYKMVTKETKDVLSGKYGATVKPFDPEVQKKCIGD
                     TEPITCRPADLIPDELDTLRNEMAQWSEQEEDVLSYALFPQVATEFFKYREAQKTKVDP
                     KAADTENGAYPV"
ORIGIN
        1 atgatcggag atccttcagg gagaacggat atgcgccaga tgatgacaga ggagaccatt
       61 cagtataact gtgactgttt cagaaaacag atgagccgtt ttattgactt ctctgagggc
      121 aaagccctta tggtaaataa tgcggactgg cttctggatc tcaactatgt ggagatgtta
      181 agggaagttg gcgcccattt ttctgtaaac aatatgctgc gcgcagagtg ttacaaacag
      241 cgtatggaaa aaggactgag cttctttgaa tttaattaca tgatcatgca gagctatgac
      301 ttttacatgc tgtacaagaa ttacggctgt aatatgcagt tcggcggaga cgaccagtgg
      361 agcaatatgc tgggcggaac agagctgatc cgccgtaagc tgggaaaaga tgcgtatgcc
      421 atgaccatca ctctgcttct taattcagag ggcaagaaga tgggcaaaac tcagtcaggc
      481 gctgtctggc tggatcccaa taagacaaca ccttttgact tctatcagta ttggagaaat
      541 gtcagcgacg cagatgtgct gaaatgtctt cgcatgctta ccttcctgcc tttggagcag
      601 attgatgaga tggataaatg ggagggcagc cagctcaaca cagcaaaaga gatcctggct
      661 tacgaactga ctgatctggt acatggcgag gaagaggcta aaaagtccca ggaagcagca
      721 agggctttat ttaccagcgg taatgcagcg gatatgccat cagctttcat cgagcagtca
      781 gacttacagg gaggaaatat tgacctcatc acacttctgc acaagagcgg tttggtaggc
      841 agccgttccg agggaagaag agccattgag cagggcggtg tggcaattga cggtgagaag
      901 atcacagatg tcaaatatgt gatcccggga gaaaagttgg acggagacgg aatcgtgctg
      961 aaacgcggta agaaaaactt ccgtaaagtg acaataaaat aatataatac aagagatgcc
     1021 gggggctgac agagcttccc ggcatccgtt acattttgtg caaaatcatc aaaatggatt
     1081 ttctctgtta atgccattgc attttacctt tggatatggt aatctggatt cacgaaaagg
     1141 tcagcgctgt acgatcgaaa acgcgcagaa aacaattcta aagcaacacc ctatatccac
     1201 atttcaaaat tctatggaat tcccgtatat tttccattta tcagcattta gagtcaaagg
     1261 aatactaata ttgtttggag ctgtactaca ttcttacagt tacaattgtt tttctgatcg
     1321 tgacgcgcct gccggaacag agaggttatg aggaatgaac aaaaaaggaa tgatatttga
     1381 agggctgaaa gtgcgcaatg agatcaaaaa agcactgcag caggaggaag gactgcccaa
     1441 ttgtattcag gaggagaacg gatatctgtc agcagaaccg ggagagcatg caggaaaaaa
     1501 tgtactcaaa ggcgagagag agctgaaacg tgtattggaa aagctgctgg aggaggatgg
     1561 agaggagatc tgtctggatg taacttattt tctcgttttt gcagcagcgc agaatcctgt
     1621 ctgcagggaa gagttaaaaa ggctggcacc ggagcagatc attggatatc agcagatgtt
     1681 tttgaataac gggtatcacg gtgattactt tttgtcctgc ctgggctatg aggaacatta
     1741 ttttgcacag gtgctcattg gtatgcttga aaagatacgg gagggcagcg aagagagggc
     1801 ggaggaagct tatcatcagt ttatgggctg catccgcaaa ggatggcgca gtgccagacg
     1861 ggagcttttt acagaagaga ctctggactt tgaacggata caggagtggg ccgggcctta
     1921 cacagaacag ccggccatgg gtatgagcca gatctgtatg atctgcctgt tggctgagac
     1981 ctgccatgta gagattaaaa agaatgtaaa tttctatctc attctggagt gtatgattga
     2041 cagaaatacg atctgggaca gtaaaaaaga ggaaatttta gaatacgagg tctggggaag
     2101 agcgggctgc gcggacagtt gtttttaccg gagactggaa gaaacagtga ggaatccgtt
     2161 ccaggcagcc ttgggattta gggtggaggg atatgaagag tttgactgtt atctgcaaaa
     2221 tcttttccat ctggggggca tagacaggaa tgtgctgtgc ggagaagaac tggacgagag
     2281 atcacggcgg ctcttactgg aactgggtga gtttgagaaa tattcgggta tggagaagta
     2341 tgtctattct ctttatattg ttttactgtc cggatatgtg aaaaaatgtc tggataagat
     2401 ccgggaaaat gatccggtca gatggcagca gaaattagat gagcaggaaa gagaaaagga
     2461 ggaattaaaa aagcagctta cagaatcgga ggagcgtttc cgcagtatga aaaggaaaaa
     2521 cagtgagctg gaagaaaaac tggagctggc agaacggact gtgcgccgca aagagaacca
     2581 gctcctgcgc gcggccaagc agcaccagtc cgaaaaacag gagcttgtca ggctgagaga
     2641 aagtctatat aattcaggca gagccggatg atgccatgct tggccgaaga aaatttcaaa
     2701 tcatctattg acaaataccc catacggcat tataattgaa aaaaagttga attgattaac
     2761 actttaaacc gatgaacaag aagagtaagt aaaaatattt attcccagag agccgttgtt
     2821 ggtggaaata cggcagtaag agtttttacc gaatggcctt gtgagggcag cttgaaacct
     2881 tcctggaggg gagtagacgc tgacggggag cttatccgtt atcaaagagc agtgtatgat
     2941 agtacatgaa agagcggttc atattacgta aaggatatga gcaatatggg tggtaccgca
     3001 ggagtttaga atttacagct cttgtcccat tggagaaatc tgatggggca ggagcttttt
     3061 tattgccgct ctttggaaag ggaggaaaaa acatgacgat cacaccggac tgcaacacaa
     3121 ttttgaaact ggcggaggaa tattccattg tccctgtatg cagggaaatc tatgcggatg
     3181 ttacaacacc gatcactctg ctgcgcaagc tcacagggct ttctaagaga tattatcttc
     3241 tggagagtat agagggcgga gagacatggg gaagatattc ttttctggga tatgacccgg
     3301 tcatgcgggt gacctgcagg gacagtaaag tatatataga aaaacaggga aagacagaga
     3361 ttgtggagac agaaaagccc ttgaatgtat tgagagagat catgaaagac tacaagtctc
     3421 ccagactttc cggcatgcct ccgtttaccg gcggctttgt agggtatttt gcatattcta
     3481 tgatcggtta cgcggaaccg gtgctccata taaaaaaggg cacatttccc gattacgatg
     3541 ttatgctttt tgacaaagtc atcgcctatg accatctgaa gcagaagata tgtatcattg
     3601 tgaatatgcg gacggataaa gtgatggaga attatggcga ggctacagcg gagatcgcaa
     3661 ggatcgccgg gctgatcaaa agcgcaccgg tacctgcggc tgaagcggag ccagagcaga
     3721 ttgatttcac ctgtaatgtg agcagggagg aatactgcag cattgtagag aagacgaaag
     3781 aatatataag agatggggat atcttccagg ctgttatttc caggcagttt tgcagtccta
     3841 tgagaggaag ccttttaaac gcttacagag ttcttcggac aacaaatcct tccccgtata
     3901 tggtttacct gcattttgat gaggaagaac tgatgagcac ttcaccggag actctggtcc
     3961 gccttcagga tggccggctg actaccttcc cggtagcagg ctccaggcca aggggggcgg
     4021 atgcagagga ggatgaagct ttggaaaaag atcttctgca ggatgaaaag gaactgtcag
     4081 aacacaatat gctggtagac ctggggagaa atgatctggg acgcatcagt cagtttggtt
     4141 ctgtggaagt gacgaaatat atgatgatcc accgttattc taagatcatg cacatttgtt
     4201 cacaggtgga gggaaccatc cgggacgaca aggatgcatt ggatgcagtt gaagctgtac
     4261 ttcctgcggg aactctttcc ggcgcgccca aaatcagagc atgcgagatc atcgaggagc
     4321 tggagagtat ggagagaggt gtctacggag gtgccatcgg ctatctggat tttgccggca
     4381 atttggatac ctgtattgct atccgcatgg cagtcaaaaa agacggtaaa gtctacgtac
     4441 aggcaggcgg cggaattgtg gcagacagtg ttccggagct ggaatacgaa gaatcggcaa
     4501 ataaagcggc agcagtgatg caggccatta aaaatgccgg ggaggtggaa gagttatgat
     4561 attgctgatt gataattacg acagttttac atacaacctg gtacagatga taggcaccat
     4621 taacccggac atccgggtga taagaaatga tgagatgaca gtggaggaga tagaggcatt
     4681 acatccttcc cacattatcc tgtcaccggg accgggatat ccgaaggacg caggaatctg
     4741 tgaagcggtt attcagagac tgcagggcag ggtgcctatc ctgggtgtct gcctgggaca
     4801 tcaggctgtc tgtgaagtgt acggcgccag gatcagccat gccagacatt tgatgcacgg
     4861 aaaaagaagc cgggtatttc ttcagacaga gagtcccatt ttcgcaggca tggaggaaga
     4921 aatagacgcg gccagatacc actcccttat agcggaggag ggaaccattc cccaatgtct
     4981 tcaggtcttg tccacggatg tggaaaatgg ggaaatcatg gcagtagggc acagagagta
     5041 tccggtatat ggacttcagt ttcatccgga atccattctc acaccccagg gaaagaatat
     5101 acttgaaaat tttttaaata taaaagctgt aagaggagat aagatcatga tcaaagaggc
     5161 aattcataca ctgatggacg gcaaggattt aaattatgag atggcaaagg cagtcatgca
     5221 tgaaatgatg gatggcattg ccacacaggc acagatggga gcttttctgg cggcgcttcg
     5281 catgcaggga gagagtatag atgaaatcac agcttttgct gaggtcatga gggaaaaagg
     5341 gatcaagatc aaacccgaga gagaagtcat agatattgtg ggaacgggag gagacgaggc
     5401 aggaaccttt aatatttcca ccacagcggc gtttgtggtc gcagcgggcg gagtgcctgt
     5461 ggcaaaacac ggaaaccgca gcgtatccag taagagcggt gcggcagatg tcctggaaaa
     5521 tctgggtgcc aatgtggctc ttgacgcaaa acagaatgag aacattctca acaagactgg
     5581 gatgtgcttt atgtttgcgc cggtttatca ctcttctatg aaatacgcgg ctccggtgag
     5641 aaaagagatg ggggtgcgca ccgtgttcaa tattttaggc cccctctcca acccggcagc
     5701 agctaccatg cagcttcttg gcgtatacga caaaaatctg gtggaaccgc tggcaaaggt
     5761 gctgggcaac ttaggtgtga ccagaggagt cgctgtgtgc ggtgaggacg gcctggatga
     5821 gatcaccttg acaggggaga ccacagtctg cgaaatacgt tttggagaga cttcctgcta
     5881 caccatatca ccggagcagt ttggaatgaa acgctgtgaa ctttctgaac tggtgggcgg
     5941 ctctcctgct gataacgcac agatcaccag ggatattctc tccgggcgtg agacaggacc
     6001 aaaacgcgat gtggtgcttt taaatgcggg tatgagtctc tatctgggga ttgacggcat
     6061 cacattgcag gagggcattg atatggcccg ggatctgata gagagcaaaa aggcacaggc
     6121 aaaatttgat gaatttgtaa aggccacaag agaacagtaa aggaggagac tgaaaaatga
     6181 tactggaaca gatagcgaga gacacagaga tccgggtgac ccagcagaaa aagaaagtcc
     6241 ctctcggaac cctgaaaaaa gcggcatacc aaatggagac agatacagga ttcccctttg
     6301 aaaaagccct ggcaaaggag ggactcagct tcatatgtga ggtaaaaaaa gcctcccctt
     6361 caaaagggat catcgcagaa gattttccgt atctggatat cgcaaaggaa tacgaagcgg
     6421 cgggggcaga tgctgtctcc tgtctgactg agccgaaata ttttctggga gctgacagct
     6481 atctgaagga gattgcggaa aatgtgaaga ttccggttct caggaaagat tttgtggtgg
     6541 aagagtatca gatatatgag gcaaaggctc tgggtgccag cgctgtgctg ctgatctgtg
     6601 cgctcatcga gccggtgctt ctgaaacgat atattcaggt gtgcgacact ttgggcattt
     6661 ccgctttggt ggaagcccat gacgagaaag aaatttcaca tgccgtgtgg gcgggagcca
     6721 gagtcatcgg cgtgaataac cgcaatctga aggatttcag cgtggatgtg ggaaatagca
     6781 caaggcttcg cgctctggcg ccgaaagaga tcctgttcgt ggcagagagc ggtataaaag
     6841 gtcccgagga cattgcgcgc ttaaaggaaa atgaagtgaa tgctgtgctg atcggtgaga
     6901 cactgatgaa gagcagggat aagaaaaaaa tgctttctta cctaaaagga gaggatacat
     6961 ccaatgagca gtaaagtaaa gatctgcggc cttaggcgtc ctgaggacat agagacagcc
     7021 aacctgtacc gtccggattt tatcgggttt gtctttgcga acagcagccg gcggatcacg
     7081 gaagaacagg cagagtgctt aagggcagga ctggcggatg gaatcctggc ggcaggcgta
     7141 tttgtaaacg ctccggtccg ggaggcagca cggatcgctg aaaaggggat catagatatc
     7201 attcagcttc acggagatga ggatgaagcc tatatccgca gtctgaagac atttactaag
     7261 aaaccggtga taaaagcagt ccgcgtacag agccgggagc agatcctgga agcggagaag
     7321 ttgccctgcg agtatctgct ccttgacacc tatacaaagg gacagtacgg aggaagcgga
     7381 aaaggatttg acctgtcgct cattccaagg cttgccagac cattttttct ggccggaggc
     7441 ctgagtgccg aaaatgtgca gagtgctctt gaaagtagcg gtgcatttgc agcagatgtc
     7501 agcagcgcag tggagacaga gggatataaa gacagggaca aggtcaggga atttatccgg
     7561 gcggtccggg aacaggattc ggacacgaaa aaccattgat tataaagaag aggatgaaaa
     7621 tatgagcaaa ggaagatttg gcaattacgg aggacagtac attccggaga cactgatgaa
     7681 cgcagtgcag gagctggagg aagcctatga gaaatacagc agggacccgg aatttaacag
     7741 ggagctggac gatttgctga aaaattatgc gggccgccct tctctgctgt actatgccga
     7801 gaagatgaca aaggatctgg gaggcgcgaa gatctacctg aagagagagg atttgaacca
     7861 taccggttcc cataagatca acaatgttct gggacaggtg ctccttgcga agaagatggg
     7921 caagacgaga gttatcgctg agacgggagc gggacagcac ggtgtggcca cagctacggc
     7981 agcagccctt atggggatgg aatgtgaagt cttcatggga cgtgaggaca cagaccgcca
     8041 ggcactgaac gtataccgca tggaactgct gggggcaaag gttcaccctg tggacagcgg
     8101 aacagccact ttgaaggatg ctgtaaatga gaccatgaga gagtggacca gaaggatgga
     8161 cgataccctt tatgtgttgg gttctgtcat gggtccccac cccttcccta tgatcgttcg
     8221 tgatttccag aagatcatcg gaaaggagat caaagaacag cttcaggaaa gagaaggcag
     8281 acttccggat gctgtgatcg cctgtgtagg cggcggcagc aacgccatgg gagcgtttta
     8341 tgaattcatc aaggatgagc aggtgcagct catcggatgt gaagcggcag ggcttggtgt
     8401 ggatacggaa aaacatgcgg caaccatcgc aaaaggaaca gagggagttt tccatggtat
     8461 gaaatccctg ttctgccagg atgagtacgg acagatcgct ccagtatact ccatttccgc
     8521 aggactggat tacccgggta tcgggccgga acatgccaat ctgaacaaga cgggaagggc
     8581 caaatatgtg ccgatcacag acgccgaagc ggtggaggca tttgaatacc tctccaagac
     8641 agagggaatc ataccggcta tcgaaagcgc ccacgcagtg gcatatgcca ggaaactggc
     8701 tccgaccatg gataaggata agatcatagt ggtaaatatt tccggcagag gcgacaagga
     8761 cgtggctgcc attgcacgat acagaggagt ggaaatttat gagtaaaata tatcaggcat
     8821 ttgaaaacaa aaaggcattt attccgttta tcacaggcgg tgaccctacg cttgatgtga
     8881 cagagcagct tttgtacgcc atggaggagg caggagctga tctgatagag atcggcatcc
     8941 ctttttctga ccctacagca gaaggaccgg tgatccagga ggcaaatgag agagccttaa
     9001 aagcgggatg caccactgac aaattgtttg acatgataaa aagggcgaga cagaaggtca
     9061 cagtgccgat cgtgtttctt acctatgtga atcctatttt tacatatggc aaggagcgct
     9121 tcatgaaaaa atgtgtggag tgcggcgtgg acggtatcat cgttccggat atgccctatg
     9181 aagaaaaaca ggagctggcg cctgcgtgtg atgcctatgg cattgacatc attcctctta
     9241 tagcacccac ttcaaatgcc cgcatcacca tgatcgcaaa ggaggcaaag ggatatatct
     9301 actgtgtctc ttctctggga gtgaccggtg tgagaagtga gatcaagacg gacatcggcg
     9361 ccatggtaga gctggtgcgc cgggccacag atgtgccctg cgccgtgggc ttcggcattt
     9421 ccacaccgga acaggcatac gccatggcaa aggtttcaga cggagccatt gtaggctctg
     9481 caattgttaa aattgtggca aaatatggaa aggactgtgt gccctatgtg gcggagtatg
     9541 taaaagaaat gaaagctgcc gtggaccggg caaacaactg agaacagcgg aggatggaaa
     9601 attccatcct ccttttttgc gtaaagcccc gcatttccag accctgcctg cgtaaccatg
     9661 cagatcagcg cggtaaatac acggatatgg gggatcagat ctgtatggcg ccggctgctt
     9721 tgggattttg ccgggtatgg tgcagtatct ccccggggaa aacgccttgc gggataatgc
     9781 cccgtaaata gtaacaaaaa tattcataat aattaaatat ttcacaaatt tttgttgaaa
     9841 aatccccgga aacaaggtac aattaaaatc ggcagaaatt ggttttgtct tttaattcaa
     9901 caaagtaaaa ccaggaggcg atttctgcat gaaaaccgga ttatcacgca gatttttcgt
     9961 gcagaatcca ggtaaataat aaaaaatgga gggctgataa atgagtaata cagcacaaag
    10021 cttggcaagt aaaagaattg cttctttact tgatgagaac agttttgttg agatcggcag
    10081 ctgtgtcaca gcaagaaaca cagatttcaa cttatctgaa aaggaaacac cgtcagacgg
    10141 tgtcatcacc ggttatggtg tcatcgacgg cagcctggtg tatgtgtaca gccaggacgc
    10201 ttccgttctg aacggaacca ttggtgaaat gcatgccaaa aagattgtca gactttacga
    10261 tctggcaatg aagacaggcg ctccggttat cggacttgtg gactgcgcag gcttaagact
    10321 gcaggaagcc acagatgcgc tgaacgcttt tggcgagatt tataccaaac aggttatggc
    10381 atcaggtgtg atcccgcaga tcacaggtat ttttggaacc tgcggcggcg gccttgcaat
    10441 tgttccggct cttaccgatt tcaccttcat ggaagagaag agcggtaaac tgtttgtaaa
    10501 ctcccccaac gctttagagg gaaatgaaat ttccaaatgt gatacttcca gtgcaaaata
    10561 ccagagtgaa gaggctggtc tggtagatgt tctgggaagt gaagatgaaa tccttgcgca
    10621 gatgagacag ctggtatcca tgctgccttc caactacgaa gataattctt cctacgaaga
    10681 ctgcgcagat gacttaaacc gtgtttgccc ggaactggaa aattgtgtgg gtgataccgc
    10741 cattgcactt tcccagatcg cggacaacaa tgagttcttt gaagtgaaag ctgcatacgc
    10801 aaaagatatg gtgaccggat tcatccgtct gaacggtgct gttgtgggct gtgttgccaa
    10861 cagaagcgaa gtttacaacg atgaagggga gaagacagag tcctttgaca atgtactctc
    10921 tgcaagagga tgtaaaaaag cagcggattt cgtgaaattc tgtgatgctt ttgaaatccc
    10981 ggttctgtct ctgacaaatg taaaaggcta taaagcaaca aaatgctctg aagccaacat
    11041 tgccaaggca gccgcacagc ttacttacgc atttacaaat gcaaccgtac cgaaggtgaa
    11101 catcgtgatc ggtgaggcat tcggcagtgc atatctggca atgaacagca aatccacagg
    11161 agcagacatg gtattcgcat ggccgggtgc tcagatcggt atgatggacg cacgtcttgc
    11221 tgcgaagatc atgtatgcag acagcgatgc tgcaacgatc aatgaaaaag ctgctgaata
    11281 tgctgactta cagtcaagtg ccctgtctgc tgccaagaga ggctatgtgg attccatcat
    11341 tgaggcagaa gatacaagaa aatatgtgat tggtgctttt gaaatgttat tcacaaagag
    11401 agaagatcgt ccaagcaaga aacacggcac ggtttaggtg aggtgaatca tatgaagcag
    11461 acatggaaaa aattaattgg tttaatcctg atcggagtat gcgctctggc tatgacagcc
    11521 tgcggcagca gcaaagactc cacaggcggt ttaaaaaagc tggatgatgc aaccgttgac
    11581 tctcttgtgg agagctttgg cggcgttgtc ggcaacattg ctgatctgaa cgaggagtct
    11641 attgcgggtc tcatggaagg cgatgacgca ttcagtgctt ccgctgcaat tgcgtgggac
    11701 ggtgccagcg aagatctggg cgcatatgtg gagacatcca aaggcgatgt ggagatcaaa
    11761 gacggaaatt atatcctgac actggcatgt aagtttgaga accgtgacgc agactgcgtc
    11821 tttacattgg ataaaaacgg caatcctctc aatgtgacca ttgaccccaa atattcaatg
    11881 ggtgaaaaaa tggcacaggc aggacagaat acacttctgg gtataggaac tgtttttgtt
    11941 atgctggtct tcctgtgttt tgttatttcc ttaatgaaat acattccggg atttgtagcg
    12001 tcctttgaca agaagaaaac tgctccggaa gaaattcaag ttccggctgc tcctgctgct
    12061 aaagctatac cggaggcagc agaggaagag gttgtggatg acggcgagct gatagcagtc
    12121 attgcggcag caatcgcagc atctgaaaat acatctacag acagttttgt agttcgttcc
    12181 atcagaaaat caacaaaaag aaattggcag agagcctaat cacaggagga aatggttatg
    12241 aaatcttata caattacagt taatggcgtt gcatatgatg taacagtaga agagggcgca
    12301 ggaaacgcag cagctcctgc ggcagcaccg aaagctgctc ctaaggcagc accaaaagcc
    12361 gctccggcag caaaacctgc agcatccgca gcaggcgcag tggcagttac cgcatctgtt
    12421 ccgggtaaag tgttcaaagt ggaagctaat gttggacagg cagtaaaagc cggcgataac
    12481 atcatcattc tggaagccat gaaaatggaa attccggttg ttgctccgca ggacggtacc
    12541 attgcaagta ttgacgtggc agttggtgat tccgtagaaa acggtgatac actggcatcc
    12601 atgaactaga atttacaaac aattgtaaat tcccgacagc taagagataa atcttgctga
    12661 tacaatagaa agcacaaatc gaaaactttc tattgtcacg aatacgaaca atgggaggta
    12721 atataatgtc taacgttaca gatacactgt ctaacctgct ccaccagaca gcgtttttca
    12781 atctgacatg gggaaattac cttatgattt tagttgcctt tggttttctt ttcctggcaa
    12841 ttaaaaaagg atttgaaccg cttcttctgg tgccgattgc cttcggtatg ctgttggtta
    12901 atatctatcc ggatattatg gcactgccat acacggacgc agcaggaatt gagcatgcag
    12961 gtggacttct tcactatttt tatctgatgg atgaatggag tattcttccg tccctgatct
    13021 tcatgggcgt aggtgccatg acggacttcg gtcctctgat cgccaatccc aagagctttc
    13081 ttttgggtgc tgcggcacag cttggtatct acatggcata cttcctggca atctttatgg
    13141 gattcaatgg aaaagcagca gcagccatct ctatcatcgg tggtgctgac ggcccgactt
    13201 ccatcttcct ggcaggtaag cttggacaga cagtccttat gggaccgatt gcggtggcgg
    13261 catattccta tatgtccctg gttcccatca tccagccgcc gatcatgaaa cttctcacta
    13321 cagagaaaga acgtaagatc aaaatggaac agcttcgccc ggtttccaaa ctggaaaaaa
    13381 tcctgttccc gatcatcatc accgttgttg tttgtctgat tcttcctaca acagctccgc
    13441 tggttggtat gctgatgctt ggtaacctgt tccgcgaatc aggtgttgta aaacagttaa
    13501 gtgagacagc atccaatgct cttatgtata ttgtagttat cttactggga acttccgtag
    13561 gtgcttctac aagcgcagag gcatttttga aactggatac cctgaaaatc gtcgttttag
    13621 gtctggttgc atttgcgatc ggtacggcag gcggtgtact tcttggtaaa ctgatgtgta
    13681 aactgtccgg cggtaagatc aacccgctga tcggttcagc cggagtatct gccgttccta
    13741 tggcagcccg tgtatcccag aaggttggtg ctgaggcaga cccgactaac ttcctgctga
    13801 tgcacgcaat gggcccgaat gttgcaggcg ttatcggtac tgcagtagca gcgggtacct
    13861 tcatggcaat cttcggtgtt taatatttaa gaaaatccat ataacgattc taaatttatt
    13921 taggattttc ttattgtcat gatttcaaaa ttttaggagg aaattaagat ggcagaggta
    13981 gtaaaaaaac ctattaagat tactgaaaca atcttacgtg atgcacatca gtccctgatt
    14041 gcgaccagaa tgtccacaga gcagatgctg ccgatcgtag ataaactgga taaagtcggt
    14101 tatcattccg tagagtgctg gggcggtgca acctttgatg catcccttcg tttcttaaaa
    14161 gaagatccat gggagagact gcgtaagttc cgtgacggat ttaagaatac gaaactgcag
    14221 atgctgttcc gtggtcagaa cattctggga taccgtcctt atggggatga cgtggtagag
    14281 tatttcgtac agaaatccat tgccaacggt attgacatta tccgtatttt tgactgtctg
    14341 aatgacttga gaaacctgca gacagcagta aaagcttcca acaaggaaaa aggacatgca
    14401 caggtggctc tgtcctacac cttgggcgat gcttacacta tggattactg ggtagacatg
    14461 gcaaaaagag tagaggatat gggtgcaaat tctatctgta tcaaggatat ggccggtctg
    14521 ttggttccgt atgaggcaac aaatctggta actgctctga aagctgctgt ggatattccg
    14581 atccagctcc acacacacta tacctcaggt gttgcttcca tgacttactt aaaagctgta
    14641 gaggcaggcg tagacgtgat cgatactgct atgtctcctt tcgctctggg aacatcccag
    14701 ccggctacag aggttatggt tgagacattc aagggaacac cttatgacac aggatttgac
    14761 cagaatcttc tggcagagat cgctgattat ttccgcccga tccgtgatga ggcgctggaa
    14821 agcggtctgc tgaatcctaa gaacctgggt gttaatatta agactctgct gtatcaggtg
    14881 ccgggcggta tgctctccaa cctgaccagc cagttaaagg aacagcacgc agaagacaag
    14941 ttctacgagg ttctggagga agtgccgaga gtgcgtaaag acctgggcga gccgcctctg
    15001 gtaactccgt cctcacagat cgttggtaca caggctgtat tcaacgtaat tatgggcgag
    15061 cgctacaaaa tggttacaaa agagacaaaa gacgttctca gcggaaaata cggtgctacg
    15121 gttaaaccgt ttgatcctga agtacagaag aagtgtatcg gtgatacaga gccgatcacc
    15181 tgccgtccgg ctgatttgat cccggatgaa ctggatactt taagaaatga aatggcacag
    15241 tggtccgaac aggaagagga cgtattgtct tatgcgttat tcccgcaggt ggcaaccgag
    15301 ttcttcaagt atagagaagc acagaagact aaggtggatc ctaaggctgc ggatacggag
    15361 aatggggctt atcctgttta atgtttagca tagaagggcg agggtgccgt ggtgacggtg
    15421 cctttggcct tcttttttta ttaaggggga cggaagcgga gatgagaggg ccggggacgc
    15481 aggaggccgg ggaacgaagc gttccgctgc cgtggagcta acctgctccc agttactaaa
    15541 ttcatcggca ttggcctctt cattaagt
//
