GCA_024463055.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaMPBGEHGH_24 (original name was: gnl|Prokka|MPBGEHGH_24)

Region	Type	From	To	Most similar known cluster		Similarity
Region 4.1	NRPS-like	1,044	43,473

gnlProkkaMPBGEHGH_35 (original name was: gnl|Prokka|MPBGEHGH_35)

Region	Type	From	To	Most similar known cluster		Similarity
Region 5.1	RRE-containing	46,642	68,276
Region 5.2	resorcinol	86,278	127,417

gnlProkkaMPBGEHGH_89 (original name was: gnl|Prokka|MPBGEHGH_89)

Region	Type	From	To	Most similar known cluster		Similarity
Region 12.1	phosphonate	301,279	314,838	polysaccharide B	Saccharide	13%

gnlProkkaMPBGEHGH_100 (original name was: gnl|Prokka|MPBGEHGH_100)

Region	Type	From	To	Most similar known cluster		Similarity
Region 23.1	phosphonate	369,342	393,184	polysaccharide B	Saccharide	30%

gnlProkkaMPBGEHGH_133 (original name was: gnl|Prokka|MPBGEHGH_133)

Region	Type	From	To	Most similar known cluster		Similarity
Region 56.1	phosphonate	173,258	201,465	polysaccharide A	Saccharide	40%

gnlProkkaMPBGEHGH_166 (original name was: gnl|Prokka|MPBGEHGH_166)

Region	Type	From	To	Most similar known cluster		Similarity
Region 59.1	RRE-containing	205,455	225,808	polysaccharide C	Saccharide	20%

Region	Type	From	To	Most similar known cluster	Similarity
Region 4.1	NRPS-like	1,044	43,473
Region 5.1	RRE-containing	46,642	68,276
Region 5.2	resorcinol	86,278	127,417
Region 12.1	phosphonate	301,279	314,838	polysaccharide B	Saccharide	13%
Region 23.1	phosphonate	369,342	393,184	polysaccharide B	Saccharide	30%
Region 56.1	phosphonate	173,258	201,465	polysaccharide A	Saccharide	40%
Region 59.1	RRE-containing	205,455	225,808	polysaccharide C	Saccharide	20%

Compact view

gnlProkkaMPBGEHGH_24 - Region 1 - NRPS-like

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Location: 1,044 - 43,473 nt. (total: 42,430 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1043 - 43473:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg4_25

AMP-binding (12..401): X

nrpys: Ile, Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALFLGVVLK
Nearest Stachelhaus code(s):: Leu or Ile DAIYLGVVLK (59% 8Å match); aIle DALVFGVVLK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

gnlProkkaMPBGEHGH_35 - Region 1 - RRE-containing

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Location: 46,642 - 68,276 nt. (total: 21,635 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

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KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMPBGEHGH_35 - Region 2 - resorcinol

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Location: 86,278 - 127,417 nt. (total: 41,140 nt) Show pHMM detection rules used

resorcinol: DarB

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaMPBGEHGH_89 - Region 1 - phosphonate

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Location: 301,279 - 314,838 nt. (total: 13,560 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

gnlProkkaMPBGEHGH_100 - Region 1 - phosphonate

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Location: 369,342 - 393,184 nt. (total: 23,843 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

gnlProkkaMPBGEHGH_133 - Region 1 - phosphonate

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Location: 173,258 - 201,465 nt. (total: 28,208 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

Legend:

core biosynthetic genes

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resistance

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

gnlProkkaMPBGEHGH_166 - Region 1 - RRE-containing

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Location: 205,455 - 225,808 nt. (total: 20,354 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1