LOCUS       c00045_gnlPro..        16500 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|POBLKHNG_334.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 15:46:41
            Original ID  :: gnl|Prokka|POBLKHNG_334
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 27943
            Orig. end    :: 44443
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16500
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[37943:43551]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15608
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16500
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16500
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             838..2364
                     /locus_tag="ctg45_22"
                     /transl_table=11
                     /translation="MAKETRIMGKRAAGILMPISSLPSDYGIGCFSKSAYEFVDWLKEA
                     GQTYWQILPLGPTSYGDSPYQSFSTFAGNPYFIDLDTLVEEGVLDKKDCEKVNWGKKPD
                     EVDYEKIYKGRYPLLRKAYENSDISKNPDYQKFVAENSWWLSDYALFMAVKDRFEGVEW
                     TKWAEDIRLRWNNAMDYYREELYFDIEFQQYMQFKFYEQWMKLKSYANSKGIQIIGDIP
                     IYVAMDSADAWAHPELFQLDQDNVPLAVAGCPPDGFSATGQLWGNPLYRWDYHRNTGYQ
                     WWISRMSYCFRLYDVVRIDHFRGFDEYFSIPYGDKDARGGHWEKGPGIDLFRKIEQALG
                     WKQVIAEDLGYMTDSVRHLVYESGFPGMKVLEFAFDSRDSGCASDYLPHNYPENCVAYT
                     GTHDNETIVGWWRSITAAERKLARDYLCDHATPEEELYKCFISLIMRSAARVCVIPMQD
                     YMGLDNRFRMNKPSTVGTNWKWRIKKRDLTKKLQKEIYDVTLRYGRKNWD"
     CDS             2693..3223
                     /locus_tag="ctg45_23"
                     /transl_table=11
                     /translation="MNYNRLENSLIDVIKEEQAKLGYMKEKIRLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVTVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             3477..4895
                     /locus_tag="ctg45_24"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDRKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             4895..5095
                     /locus_tag="ctg45_25"
                     /transl_table=11
                     /translation="MEQVMKRLVIKNKRKIWLWFLFIVLLILACRAAYVTGNKNMQIRD
                     EAVEEQQVENVVGQDKVERLC"
     CDS             5089..5853
                     /locus_tag="ctg45_26"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMDKLENARVAVFGIGGVGGYVCEALVRSG
                     VGAFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             6167..7351
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.3; E-value: 1.8e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg45_27"
                     /sec_met_domain="MFS_1 (E-value: 9.7e-25, bitscore: 78.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(7764..8729)
                     /locus_tag="ctg45_28"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDARTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(8988..9626)
                     /locus_tag="ctg45_29"
                     /transl_table=11
                     /translation="MNTTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTP
                     GLSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFI
                     VCIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYI
                     QGIVSSLGVSNPIVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             complement(10001..10360)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_30"
                     /sec_met_domain="ALS_ss_C (E-value: 3.1e-23, bitscore:
                     73.0, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSREDKAELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVV
                     RGGSVGIESISMMER"
     CDS             complement(10562..11275)
                     /locus_tag="ctg45_31"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDNAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAMKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPRLKVFLQTH"
     CDS             12038..13294
                     /locus_tag="ctg45_32"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKVTRASIMNNN
                     ARIGRKAKAQMKNEKMEEP"
     CDS             complement(13363..13872)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_33"
                     /sec_met_domain="ALS_ss_C (E-value: 1.5e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(13890..15608)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_34"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-48, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
ORIGIN
        1 gtaagaacct tccagatagg tgttggcaat catgaagttt ccgccatgtc caggaccgga
       61 aagcaggatc atatcaaggt cataacgttt gatgacacgg ttgcagtgtg cataaacgaa
      121 gttctgtccc ggtacagttc cccagtgacc aacaattttt ttcttgatct gatccatagt
      181 taatggctct ctcagaagcg gattgtcaag aagatagagc tgtccggcag acagatagtt
      241 agctgcacgc cagtaagcat cgattttgtc aagcatttcc tgatttaaag gctgcttttc
      301 cagacataat ttgttgtctt ccattttctt acctctttct ttgtctttga tgtgtatagc
      361 ttaagatgtc gaagatatct gtataagaaa ttttctgacg gtagttaatg ataaacgttt
      421 ctcaacagat aagttggagt gttactttgt tattttttaa ccgaacacat cctatcatat
      481 cagaaatgaa acgtaaaata gaaatattgc attgtaatta taagtttttg atatggataa
      541 aaaataagct ctttctgatg aaatgcggag cagttattcg gtatagagct gcgtagcgaa
      601 gcagattgtg aatatccgct tgacgacgat tctctgagtg gaaatgattg gtgtttaata
      661 tggaagatga cgaaaagaac taagcaatga ttagtaattt tcacgaaaaa atggataaca
      721 tgaaagttgt attgcaattt gcacaaaaaa tagatataat aaaaaaaaca attgcgcata
      781 aggtatagaa aaactgctta tatgtactag ataaagtata ggcggtaaaa gtgaagaatg
      841 gcgaaggaga caagaatcat gggaaaaaga gcagcaggaa tattaatgcc gatcagcagc
      901 cttccatcag actatggcat cggatgtttt tcaaaaagtg catatgaatt tgtagactgg
      961 ttaaaggaag ctggacagac ttactggcag attctgccat tgggaccgac cagctatgga
     1021 gattctccat atcagtcttt ctctacattt gcaggtaatc catattttat tgatctggat
     1081 acacttgtgg aagaaggagt tcttgataag aaagactgcg agaaagttaa ctggggaaag
     1141 aagcctgatg aggtagatta tgaaaaaatc tacaaaggcc gttatcctct tctgagaaaa
     1201 gcatacgaga acagtgatat cagcaagaat cctgactatc agaaattcgt agcagagaac
     1261 agctggtggc tgtcagatta tgctctgttt atggcagtaa aagaccgttt cgaaggtgta
     1321 gaatggacca aatgggctga ggatatcaga ctccgctgga acaatgccat ggattattat
     1381 cgtgaagaac tctattttga tattgaattc cagcagtata tgcagtttaa gttctatgag
     1441 cagtggatga aactgaaatc ctatgcaaat tcaaaaggaa tccagatcat tggagatatt
     1501 ccgatttatg ttgcaatgga cagtgctgat gcatgggcgc atccggagct gttccagctg
     1561 gatcaggata atgtaccact ggcagtagca ggatgccctc cggatggatt ttctgcaacc
     1621 ggtcagttat ggggaaatcc gttatatcgc tgggattatc acagaaatac aggatatcag
     1681 tggtggattt ccagaatgag ttactgcttc agactgtatg atgttgtgcg aatcgatcat
     1741 ttccgtggat ttgatgaata tttttctatt ccatacggag ataaagatgc aagaggcgga
     1801 cactgggaaa agggtcccgg aattgatctg ttccgtaaga ttgaacaggc gcttggatgg
     1861 aagcaggtta ttgcagagga cttgggatat atgacagatt ccgtacgtca tctggtatat
     1921 gagagcggct tcccgggaat gaaggttctg gaatttgcgt ttgactccag agattccgga
     1981 tgtgccagtg attatctgcc acataactat ccagagaact gcgtggcata tacaggaacc
     2041 catgataatg aaactatcgt gggatggtgg aggagcatca cagcagctga gagaaaactg
     2101 gcgagagatt atctgtgtga tcatgcaaca ccggaagaag aactgtataa atgtttcatc
     2161 agtctgatca tgcgcagtgc tgcgcgcgtc tgcgttatcc caatgcagga ctatatggga
     2221 ctggacaaca gattccgaat gaataaacca tctacagttg gtacgaactg gaagtggaga
     2281 atcaagaaga gagatcttac aaagaaactc cagaaggaaa tctatgatgt gacacttcgt
     2341 tacggacgta agaactggga ttaaatacat aatgaaataa ttggaataat gacagcgttt
     2401 cggatataaa taatattcgg aacgctgttt ttttaaccga atcaagcagt tatttggtta
     2461 aaaaagcaac gaagtggttg gttttatctg ttttgtttta tccagtcaga gtcatttgtc
     2521 agagggaaaa aagaacagtt tcgcaaggtc tttatttttg tatgaaaaag aaaacattga
     2581 aattgttttg acgggcgtac aattgaaaaa gaaatgcatt gattttcggg caatgtctga
     2641 taaaatatta accagaaaaa gcaaaagaac agattttcag gagggaaaat aaatgaacta
     2701 taacagatta gaaaacagtc tgattgatgt gattaaagag gaacaggcga agcttggata
     2761 tatgaaggag aagattcgcc tttattatcc gctcagttct ctgaatcatt tctttggcaa
     2821 tgagacggat gctgcaggca tgatggagat tttaaaagat tttccttctt atatagaaga
     2881 gaaatttggt gaagtaacag tatcacacag aggagatcgt ttctgcttca ctgtttcgga
     2941 aaaagcttcc gaatatgtac ataataatat gaaagagaat gaattcatca aggcattgat
     3001 cgaactggtt ggcagacatg gatgtacgat agaggaaatt aaagaactgt tccattctta
     3061 ttcagataaa atcattactg aaccaatgga taacgaggag tttgatgtga tgatccgctt
     3121 tgatgacgga tcagatcctt attattattg ttttaaagat gaaggatgcc atatcattta
     3181 ccacagattt ctgccggaag actatgcaga ttttggattc tgataagaat gagtgaaaaa
     3241 ttttccaact gtcggatcag caaaaatata tgtgatattt gcaacaaaag tatgttattt
     3301 ttttgtcaaa tatcaacaaa aataagtcga aattctatat tgacagatag tctcaataat
     3361 ggtaattttt atttgattta atgttttcat ttatagaaac aggtaaaatt ttattacatt
     3421 attttacagg aataaaatag ataaaattga gttgacagtt tggagggaaa gattaaatga
     3481 gaaaaaccaa aattatctgt acaatgggac cgtctactga taagggcgat gttatggagc
     3541 agcttgtgag agagggaatg gacgtagcac gtttcaactt ctcacatgga cctcacgatg
     3601 agcagagagg ccgtatccag aaactgagag aacttcgcaa gaaatatgac agacctgttg
     3661 cagcacttct tgatacaaag ggaccggaga tcagacttgg atgcttcaag gatggcaagg
     3721 tttctctgga agaaggacag atatttacat ttacaaataa agatattgaa ggaactaatg
     3781 agtgcgtaag cattacttat aaagagcttt ataaggatgt gcagccgggc ggacatattc
     3841 tggttgatga tggacttgta gacctggagg ttcaggacat cgcaggaaag gacattgtct
     3901 gcaaggttat taatgcaggt gtgattggcg acaggaaggg tgtcaatgtt ccgggtgcaa
     3961 acctgaagat gccattcatc agtaaaaaag accatgatga tcttctcttc ggtatccagg
     4021 aaggatttga tttcgttgca gcatctttta cacgtactgc aaacgatatc cgcgaagtaa
     4081 gaaaaatcct gaaagaaaac ggcggtgaag agattcagat cattgcaaag attgagaacc
     4141 agcagggcgt tgacaatatc gacgagatta ttgaagcagc agatggcatc atgatcgcca
     4201 gaggtgacat gggtgttgag atcccgccgg aatatgtacc tgttatccag cagaaaatca
     4261 tccagaaagt ttacacagca ggaaaaccgg ttattacagc aacacagatg cttgactcca
     4321 tgatctctca tccgagacca acccgtgcag aggctacaga cgttgccaat gcgattttcc
     4381 agggaacaag tgcaactatg ctttcaggag aaaccgcagc tggtaaatat ccggtacagg
     4441 cacttcagat gatgagccgt attgcagaac atatggagca gaatattgat tacaatacaa
     4501 tctttaagaa aacagacaga aatgagaatc cggatattac aaatgcaatc gcacatgcaa
     4561 cctgtctgac cgcaatcgac ttgaaggcca gtgcaatcct tgcagtgaca aaatccggaa
     4621 gcacagctca tatgatgtcc aaacacagac caggatgtct gatcggtgca tgcacaagtt
     4681 ctgagagagt ccttcgccag ctgaatctgt cctggggtgt ttacccgatg ctgatcaagg
     4741 aagaatacag ttctgagatc ctttgcctga gagcaatcga agcagcacag aagcataaac
     4801 ttgtaaaagt tggtgacact attgtatttg ccggtggtgt accgcttgga attccgggaa
     4861 gaacaaacct gatccgcgtc tgcacagtag aataatggag caggttatga aacggttagt
     4921 cataaaaaat aaaagaaaaa tctggctctg gtttctgttt atcgtgcttc tgatcctggc
     4981 atgcagggct gcgtatgtta cgggaaataa gaatatgcag ataagagacg aggcagtaga
     5041 ggaacagcag gtagagaatg tagtgggaca ggataaagtg gagagattat gctgaatcaa
     5101 ttttcgagaa ctgagcttct tcttggaaaa gaagcgatgg ataaactgga gaatgcccgt
     5161 gtggcagtat ttggaatcgg aggagttgga ggttatgtat gtgaagcatt ggtcagaagc
     5221 ggcgtagggg cctttgatct gatcgatgat gacaaagtat gcctgacgaa tcttaacaga
     5281 cagattattg ccaccaggaa aactgttggt caatataaaa cagaggtgat gcgggacagg
     5341 atcctggaca ttaatccgaa agcagatgtg agaatccata actgttttta tcttccggag
     5401 aatgctgctg atttcgattt tagtgagtat gattatgtgg tagatgctgt ggacacagtg
     5461 actgcgaaga ttgaactgat catgcgtgca aaggaggcag ggactcctgt tatcagcagt
     5521 atgggtgccg gaaataagct ggatgccagt gcgtttcggg tggcggatat ctataagacg
     5581 aaggtgtgtc cgctggcgaa ggttatgcgt agagagctga agaagcgtgg tgtgaagaaa
     5641 ctgaaggttg tttattcaga ggaacagccg atcagaccaa ttgaagatat ggcgatcagc
     5701 tgcaggtcgc attgtatttg tcctccgggt gctgcgcata agtgtacgga gcgcagagat
     5761 attccgggga gtgtggcctt tgtgccgtct gtcgccgggc tgattattgc aggagaggtt
     5821 attaaagacc tgactgcgga gtacagaaga taagaagtgt ttattttgag atgtgtatgg
     5881 tgtcagaaat ggtatggtac acatcttttt ttgcgggaaa tatttggaat cggatggggg
     5941 tattactttt tggattttat ggaattgtta tagggaaaaa gtcaaaataa tataaaaatt
     6001 tatgggattt tcaaaagata atgaaagaaa aaggagagaa tctgtgatac actgtcatta
     6061 ttgacggata gaaatctatt agaactgtgg agatatagaa gtttggtgga tcaatgtctg
     6121 aatgatgtca gcttaataaa tttcagattg gaggatataa catcggatga aaacaaatta
     6181 caacagaaca gtgcaggcct gttttatcgg atatgtagtg caggccattg tgaacaattt
     6241 cgttcctctg ctgtttctga catttcaggg cagttacggg atttcgctgc agaagatcac
     6301 acttctggtt acatttaatt tcgggatcca gttgctggta gatctggcat cgattggatt
     6361 tgtggacaga ataggttatc gtgcatctat gatcctggca catgcaatgg cggctgcagg
     6421 tctgattttg ctcacagtat tgccggagtg cctgggagat ccgtttgtgg gacttctcat
     6481 tgcagttatg atctatgcca tcggaggcgg attgctggag gtgttggtaa gtcctgtggt
     6541 ggaagcctgc cctacagata ataaggaaaa agcaatgagt ctccttcatt ccttttactg
     6601 ttggggacat gtgggagtgg tacttctttc tacattattc tttcgtattt tcgggattgc
     6661 aaactggaaa tatatggcgc tggtgtgggc attgattccc attgcaaatg gaatcctttt
     6721 taccagagtt cccattgctc cactgctgga tgagggtgaa aaggggctga ctatgggaga
     6781 gctttttaag aaaaaaatct tctgggttct gatgttaatg atgctctgtg caggagccag
     6841 tgagcaggcg gtaagccagt gggcttctac tctggctgag aaaagctttg gaatcaataa
     6901 aactatcgga gatctggcag gtcccatggc gtttgcaatt cttatgggaa gttcaagggc
     6961 attttatggg aaatttggag ataaaatcaa tctggaacgc tttatgcaat acagtgcagt
     7021 tctgtgcatg gtttcctatc tgatgatcgc atttatcccg gtacctgcgt tgggaatcct
     7081 tggatgtgcg gtttgcggtc tgtctgtagg tattatgtgg ccgggaacct tcagcatggc
     7141 ggctgcctca gtaaagcgtg gcggaacagc cttgtttgcc ctccttgccc ttgctggaga
     7201 tgtgggatgc tcatccggac caacctatgt ggggatgatt tcaggagcac tgaatgataa
     7261 tctgaaactt ggaatctttg cggcactgat tttccctgtg ttgatgataa tggggattaa
     7321 gatgattgga agtctgcaaa aatatgattg agatatatta aaaagtatgg aacgattaat
     7381 ttttcatatt gatgtaaaca gcgcatttct ttcctgggaa tcagccagaa gggtaagcca
     7441 gggactgccg gatctcaggg agattccctc ctgtgtggga ggaaatccaa agaaacggac
     7501 agagtacaca cgctgttccc ggacgaaata ccggagaaaa tgtggccact tcctgtccgt
     7561 aacctgttat ttctgggaaa agcctccgag cagaagcttc tgaatcaggg aatccgtact
     7621 attggtgatc tggcaaggga acgggaagca aatgtacagc tctggcttgg agaaaaacca
     7681 gagcacagat gaaaaatgaa gacagacagg aagaataaaa gcgcagagat gatacttttt
     7741 ctctgcgctt ttatagcgga ctgttataca tatttcagaa attcttcatc ctggatccgg
     7801 gaagtatgga tggcattttg gatagcctga gccatgactt ctgcggcgag agttcctgcc
     7861 atattgatat ctacagaaac atcgccaatg ctggcagcat agatggaatc gccgtcagcc
     7921 atagttgcta caggattgat gcatctggca taggcacagc gggtcataga ggcaatttta
     7981 ttcagttcag cctttgaaaa tgccccattg gtgatcacag ccccgatggt ggtattgccg
     8041 gtaaactggt catgaggtgt cataaagcgg tataattcgt ggacactatc cagaaacccg
     8101 cttctgtcag gcgttttcag ccctgcgatt ttctgaccat tttgtggact aaagatatct
     8161 cccagtgcat tgacaacgac aattgccgcc atctggaaat ttcccactga tacagcggca
     8221 ataccaagac ctgacttcat ggattgtttc ataccgtaaa gttttcccac agttgcaccg
     8281 gtacctgcgc cgatattccc ggttctggca tctgttcctg caaatgcctg acggcaggct
     8341 tcttcgccca tttttgcagt tggacgtatt ttaggatctc cgtaagagag gtcatagata
     8401 caggactggc atacaagagg aaccagggct gcaccggtgt tataaccgat attttgtgat
     8461 tccagatagt tcatcacacc gtcagcagca gccagtccat aagcagaacc tccggacaag
     8521 acaatagcat tgatgggatt gtcggcagtg acaggagagg tgagaggagt ttctctggaa
     8581 gcagggccgc ctccgcttat atcgcagcct gcttttgctc catttggaaa ataaagaaca
     8641 gttacaccgg tcttcgcatc atggtcagaa gtatgaccga tgcgtaaatt tgaaagctct
     8701 gtaatagaaa tctcttttaa taatgacata aaaatctcct ttattatgtg atagcaattc
     8761 tatgaaatac tgagagcaat ccagcccatc agaatgtgaa gtactgcgtc agatattttc
     8821 cttgtctttc gcactctgct gaactgtctt gattgcatta ttttgtgaga ttgctataga
     8881 tattaattga atcaggtagg atttctgttt taaatgtgcc agataaaaaa acctgactac
     8941 ggtgacaatg tagtcaggtt ttttggaaaa ggctgttctt ttaaagatta tgcacgtttc
     9001 agtgccacag aaagtgcctt ggaaacgata cttcccacta caaagcagaa gcccgcttcg
     9061 atcagtccct gaacgcccac aaaagcagca acgaagacaa taggattgct tactccaaga
     9121 ctggaaacaa taccctgaat gtaatctgtg ttgtagaaga agagacataa aaagcccatg
     9181 aagaagaaag tattcagtaa cgggcatgcc agtgaagcaa cgtaatagga aaatttcttc
     9241 gccggtgatt tatataatgc tgcgaaaata agtcctgtga tccatccttc cagcacacgt
     9301 gccacgatac atacaataaa agtgccaaat ggattaatgt taaaaagtgc ggcagcgaaa
     9361 gctgaacttc ctgtgacagc catatagaag ctggttgcac cgaaagcaag tccgcataca
     9421 gcaccacctt tcggtccgag gatgatagct cctacagcta ccgggatggt gagaagagtg
     9481 atggataagc cgggagtacg aaggtagccc agcggggtaa aggacatgag cagaataatg
     9541 gcaatcatca tagccagctc taccatgtaa agagtgctgc ttctttttgc ggcagctgtt
     9601 gtagtagttg tagttgttgt gttcatatga attctccttt tggtctgata aaacggcgca
     9661 atgcgtcccc tgcttttcag acagtttaga gtatggggat caggcgttat gaaaaatata
     9721 catcagaaca aaagatatga aacaagaaat atcttccggt aaaagtttcc ggtgtgtaga
     9781 cgccttacag gtcgcctcac aaatttaacc agactgtgaa gtggatgact ttatccacca
     9841 gactgtcaga tgtggaaatc agatgcattt tctttcgaat aacgctcccg taaacaataa
     9901 cacatttgat taaaaactgc aatattttat agtatgtttg aaaataaata caggatatag
     9961 aggtgtttct atatcctgta aaaaatattg attatgagat ttagcgttcc atcatgctga
    10021 tggattcaat tccaacgctt ccaccgcgta ccacttcaat tctgtggaat tcttccttga
    10081 tcagtttaac aactgcatca ttcttggtgg ctgtctggac aaattccaga agcagactgt
    10141 ctttgccata gtcaatgact tttgccttga aggtttctgc aatctgaaac agttctgctt
    10201 tatcttccct ggagcagttg aaaaccttga tatagagaat ttctttcatt ctgacaaata
    10261 catctgtgaa gtcgattacc ttgataacct cgatcatgcg gtttaactgt tttttgatct
    10321 gttcaaaggt ttcatcatcg ctgactgttg cgatagtcat tcgggatact gtggggtcct
    10381 cggtggttcc tacagtaaga ctgatctatc acgagatatg taaatggtta agtgagcttt
    10441 gttaattaaa atatactaaa atattgtctt ttttgacaag aaattataga aaataaacaa
    10501 aataacacaa tgcaaaaaac aatgcataaa ataaaagaat gtccctttga ggaacattct
    10561 tttaatgtgt ctgaaggaaa acttttaatc tgggaagctg gttgttaagg ataagagttt
    10621 ccggaaacat gagctggtga acgaattctt cggcataggt gaaatctcca acatgttctt
    10681 ttccgtggct gtcgctggac aaaataacag gaagctgata tttctgacag agatacagga
    10741 ttctggcggc attggctctt gtgtctcccc gatatcctcc gggtgcgagg gaagcttcgt
    10801 ttatttcaaa aataacattt tcccgtaaag ctgctcttgc cagcgtttca taatctacag
    10861 ggaaatgtgt atcgtcgcag tggccgagta tttttacagc aggatgtttc attgcattga
    10921 tgtaagcttc tgtattctga gatacagagc ctgaacggta gttctgccga tgcatactga
    10981 tgatagcgta atccaggttg ttcagcagtt catctgacag atctgtatgt cctgcattgt
    11041 ccaggatgtt tagttcaact ccgtaaagaa tatctatgcc gaatcttttt ctgggataaa
    11101 aaggaaggct tctgaaataa gaagaagttc cggaggccag agttcccggg ccgtggtcag
    11161 aaatcccaag gagtttcagt ccttttttgc tggctgcttt tgccatgtca gagatggtac
    11221 aggtggttcc gtgaccgctg gcgatagaat gtgtgtggat gtcagaaaga tacattgttt
    11281 gtctcctttc cagagcggtt tctatatatg ataagagcct tacggaagat gcaaagctgc
    11341 tgtttgatgg tacattcgtt atattcaagt atgacagatg aggatttaaa tgtcaatgag
    11401 gaaacaaaat aaaaacaact gaaatacaac aaaaatcaaa taaaaagcaa cacaaataaa
    11461 cggctgatac atgttaaatt atgttgactt cgggaaaatg agaaggtata atgggactat
    11521 atgaaaacac gggggcttat tgctgatcaa tgacagcgat agcactgttt gcttatgtgt
    11581 agacagttac ttcatgagaa aggagtaaca tggaaaaatt tcaaacatca gacatttccg
    11641 gaattctctt atgaatggct ggaggctgaa ctggatactg gtatgattcc acaaatatgg
    11701 acagcgaaga aattgctcct aacctttatg actaatcgat aagtatatat cgagaggaaa
    11761 tgaatcctca gaattaagta aaaaaagtta ccgggaacaa tgtgaccggc agcgaaatac
    11821 agacgccgca ctgccgtatg gcaagtgcgg cgttgttgtt caaaactctg atagcagagt
    11881 gaaatcaaac aaatataaat acagtaacag ctcagacaag atgatgcaaa taaagacatt
    11941 tttttggaca aacgaggttt ttaccctgga gagcagatca gggtaaaatg aaatcatcag
    12001 atatgaagag cgcaattcat atattggagg aagaacagtg aaaagtacgg aacggttaat
    12061 ttttcatatt gatgtaaaca gtgcatttct ttcctgggaa tcagccagaa gggtgagcca
    12121 ggggctgccg gatctcagag aaattccttc ctgtgtagga ggagatccaa agaaacggac
    12181 aggtatcgtg gttgccaaat ctatccctgc aaaaaaatac gggatccaga ccggcgagcc
    12241 agtagccatg gctcttcgga aatgtcccaa tctggtgatc gttcccagtg attttgaatt
    12301 atacgataaa tgttcccggg catttaaagc aatctgtgct tcctttgcac ctgtgatgga
    12361 atctttttcc attgatgagg tatttctgga tatgacaggt acttctctga tctatcctga
    12421 ccctgtagct gctgctcatg agctgaaagg caagattcac agagagctgg gatttacagt
    12481 aaatgtagga atttctacca ataagctttt ggcaaagatg gcatcagatt ttcaaaagcc
    12541 ggacagagta cacactctgt tcccggatga aatcccggag aaaatgtggc ctcttcctat
    12601 ccgtaatctg ctgtttctgg gaaaagcttc cgagcagaag cttctgaatc agggaatccg
    12661 taccatcggt gatctggcaa gagaaagagc atccaatgtg cagtactggc ttggggaaaa
    12721 aacgggacat cagctatggc aatatgccag aggtatcgat gattcccctg taaaagcagt
    12781 gcctgatgag gcaaaaggtt tcagcgtgga aactactttt aacgatgata ttacttccat
    12841 agagcaggtg tttcccatac ttttggagca gtgtgatgtt ctggcaacca gaatgcgcag
    12901 aaaagataag aaatgcaact gtatttccgt gactttccgt actttggatt tcagaaaccg
    12961 ttcacaccag acaaagctgg aaaatgctac agatcttaca gatgaaattt atataaatgc
    13021 tacaagactt tttaaagaat tctggaaagg acagccgcta cgtctgattg gtgtggcact
    13081 gacaggcctt acagatggca cttatgaaca gatgtctctg tttgaagata cagaaaataa
    13141 agaacgccac agaaagctgg atgcagctat ggatgagatc cggatgaaat ttggaaatga
    13201 taaggtcacc cgtgccagta ttatgaacaa caatgcacgg attgggcgaa aagcgaaagc
    13261 acagatgaaa aacgaaaaga tggaagaacc gtaagtaaag ggaggactga gcattaagaa
    13321 caatgcgaca atcctccctt tataaaaatt tcagaaaaag ttttatcgtt ccatcatact
    13381 gatagattcg attcctacac ttcctccacg taccacttca attctgtgaa attcttcctt
    13441 gatcagtttc actactgcgt cattcttggt tgctgtctgg acaaattcca ggagcaggct
    13501 gtctttgcca tagtcaatga cctttgcctt gaaggtttcg gcaatctgaa acagttcaac
    13561 cttatcttct ttggaacagt taaaaacctt aatatacaga atctctttca tgcggacaaa
    13621 tacgtctgtg aaatcaataa ccttaataac ctcgatcata cggttcaact gttttttgat
    13681 ctgctcaaaa gtttcatcat cactgacagt tgcgatcgtc attcgagata ctgtggggtc
    13741 ctcggtggtt cctacagtaa gactgtccag attgtagctt tttccggaga aaagtccgga
    13801 gattttggac agaacaccta cctggttctc aacatagaga gaaatccatc tttttttcat
    13861 tcctttatcc ataataattt tcctcctgat caacagtcca taatcatatc ttctagagtt
    13921 ccgcctggtt tgatcatagg ataaaccatt tcctcagggt caatgatgaa ttcaattact
    13981 gtaggtgcct ttgtgttctt ttttgcttcc tcgaaggctg ctgcaatttc ctctttcttt
    14041 gtgacacgga ttccttttgc cctgtagctc tctgcaagtc tgatgaaatc cggtgtgtac
    14101 tgtggatatt ccatgccttc agtgcggcgg gaaagtgctc ctgcgcgcag attggtcata
    14161 gcatagcgtt tgccgtagaa aagcttctgc cactggcgta ccattccaag gtattcattg
    14221 ttaaagatgc acaggataac aggaagttct tccagaactg cagttgcaag ctcctgaatg
    14281 ttcatctgca caccgccgtc accggagata acgatgacag gtctgtcggg atttccgatt
    14341 ttggctccga tgccgcctgg aagaccatag cccattgttc ccagaccacc ggacatgatc
    14401 atctgtttgc cctctgtgat ttccgcatac tgggagacaa gcatctgatg ctgtcctaca
    14461 tctgttacga taatactgtt ctcaaactgt tcgttgatct ctttcaggat atccatcgga
    14521 cttaaaagat catttggacg cattttaagc ggatgctctt ctttccagtt tttgatcagg
    14581 ttaagccact tgtccgttga acattcctgg acgtattcgt tcattttggt gatagcctct
    14641 tttgcatcag caacaatggg gatatccacc tgaatgtttc gggaaatgga tgctgtatca
    14701 atatcaatgt ggataatctg ggcatgtggt gcaaattcat gaagttttcc ggtgattctg
    14761 tcattgaatc tggttccgat ggagaacagc acatcgcagt tgctgactgc catatttgct
    14821 gcataggcac catgcatgcc aaggtttccg atatagagtg gatggtctgt ggggatagag
    14881 ccttttccca ttacggttgt gacaaccggt acttttgtct tttccactac ttcccggaaa
    14941 atttcatggg cgcgggagat tactacaccg ccgcctgcca ggaataaggg acgttttgct
    15001 ttatttaaaa gtttgatggc acgtttgagc tggccgatgt ggacatctgt gttgggcttg
    15061 tatccgcgga tatttacatt tttaggatat tcagcgctgc cgagttctgc cattacgtcc
    15121 tttggaaggt cgataaggac aggtcccgga cggccggtgc gggcaatgta gaaggcttct
    15181 ttgataattc tgccaaggtc ttcacgtctg cggacagtaa cgccgtattt ggtgatgctt
    15241 ctggtgattc ctacgatgtc tacctcctgg aatgcatcgt tgccgatgag gtggcgggct
    15301 acctggccgg tgaagcatac aagaggtacg ctgtcatagt tggcggttgc aagtcctgtt
    15361 acaaggttgg ttgctccggg accgctggtt accagacata cgccgacttt gccggtggtt
    15421 ctggcgtagg cgtcggcttc gtggacaagg gcctgttcgt gacgggggag gatgattttg
    15481 acatcgtcct gtttgtagag ttcatcactg atgtcgatgg tacaggctcc ggggtagccg
    15541 aagaggtatt ctacgccttc ttcttttaag gctttgacta agagtttgtt gccggatatt
    15601 tgtttcatat ttgggtaaac ctcctttgtg tatgtggata ggacgctcag aaatttattt
    15661 gtttggtgtg cggtttcgga gcctagtaga tctaagtgtc tgaaaatctg ctaaaagcgt
    15721 tcagaaaaat ctcaaactcg ctgcgctcag acagtgagat ttttctgaac aacgcagatt
    15781 tccaggcact aagatctaca cgactcctgc aaatgcacac caaacaaata aatttctgag
    15841 ctgtgtattg gctgatacag gggcagaatg gcgctgcgct gattctgctg agaacgctgt
    15901 aaagcagctc ccacaattct gaatatagta aaaaacgccc tgggcttgtt tgcccagggc
    15961 gaaaatgttt ccgcggtacc acctgtattc agagtctggc tctgcacttt gtcagtactg
    16021 atatactgtg ttcctgtaac gtggaactga cgttgaagcc tacttggcat gtctgtctgg
    16081 atctatggat catcagactg gatatgcggt ttggttcact gctcgggggc tacttccaca
    16141 attcgttcac gaaagctcgc accgactgct ttctctctgt gcttcccggg gttgtgtact
    16201 cctccctgtc atggcatttg gctgatatag ggatattcat tgtccgaata gggtggacaa
    16261 atgttttctt gggttacatt atacatttat agagaggaaa ttgtcaaccg ggttttggat
    16321 aattgctgta aaatttatgt tcctgaatga attttggcta cgttactgag aacggagtga
    16381 acagtaatgt aattgacaga tttctatatt gctgatataa aaaataaata atacagatgt
    16441 ttggaaggtt attaacagtt aaatataaat tataaaatca tataagcaca tgttgagttt
//
