LOCUS       gnlProkkaKGDADLMN_16   15291 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KGDADLMN_16.
ACCESSION   gnlProkkaKGDADLMN_16
VERSION     gnlProkkaKGDADLMN_16
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 14:00:45
            Original ID  :: gnl|Prokka|KGDADLMN_16
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15291
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15291
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[661:5291]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      662..5291
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..15291
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /detection_rules="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /kind="chemical_hybrid"
                     /product="LAP"
                     /product="thiopeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..15291
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /product="thiopeptide"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /rules="((YcaO or TIGR03604) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /tool="antismash"
     protocluster    1..14502
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[661:4502]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      662..4502
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03604) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="2"
     CDS             3..665
                     /locus_tag="ctg16_1"
                     /transl_table=11
                     /translation="MNYQIDNNNDFKYMSTHINYKKAALHTLMHSIEKFLTYESERNKE
                     NTLWIADLDKDRFYIRGIASFIKKESSIHLIERIDITAKKLLQTIYHMTEIKEVLIGID
                     YLFKKDVGIVYLIDEDHYILYKSEVTTDFNESIIRGLTEIISNKANGLLKKGESVELSS
                     FQVRDIGRKRPNSLILAEMLEVFSDYDIKEKPWIYQPLFESSNLLIGSFQLTGENLS"
     CDS             662..2353
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_2"
                     /sec_met_domain="YcaO (E-value: 4.7e-66, bitscore: 215.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.2e-79, bitscore:
                     259.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMYSINKYYQKVKKEDIHGKVNYYETSSYVFIGPYVNDIEDPCFN
                     CFKEAVKANGSRYYWCIEQERTELTSFNLFADDDKCTEELRGAVLIFNKNTGSIEKKEI
                     YKNAFCENCSSDFFENKILKDNHNEKLNKEGRVVSFTNVINKLKKHEKLLIDQDTGIGR
                     MLFRDAESDVIPMYGIEAYIGQRQYHSYGRAESLSASKYSAILEMIERHASMIPQFTKP
                     LRASYHQLKQKKMDVINPESFILHKSVEGEHLYSHDKEIYWTACRRLDNNKEVLIPEQL
                     IYFDNQIIRGENRFIYETSNGAALGNSMKEAVMYGLFEVIERDCFLVHWYCKKTPKRID
                     VSSSNNLQIKLVLKQLDDLGYDVHLFDITLETDIPAVWVLAVNRKDGANLKYYNAAGAH
                     YNPEKAIFSGLVEVATSALIYEKKLDKEKSHLNYLIQNPSGVKKMEDHVNYYSFEENGK
                     AFDFLLNNLEQMELIEVHKMTPAFPFTYDALKRAVLDKHPDIYIADLTQYLTEKLDFHA
                     VKILIPSLQPMTFGLQNERLNLERLNQYCEDLSLLKNKEREPHPFP"
     CDS             2350..3663
                     /locus_tag="ctg16_3"
                     /transl_table=11
                     /translation="MSITLNDLTFNRYEKNRKSLSFQFVSPRGTSFKYEKDQKRNSHQN
                     KPFRKLALFVEELFRFQSYEYQSPYSFHKYAPSARGIYCLYPYVICMGYVWLYDALDHR
                     WVCIGYVPSKVQAVELIISCDFWRLCSVYGSFGLALGLLELGHMTADIKMDSEDHGFPV
                     KKVGYMFNRWHYSKILKAPEDILLGCLIEFEQSKPIDQPDVRHNIYKYKKTYNYQKELL
                     QIGIMDYINALTKMDESLKNNDWFYEESSKGNKAHRHSGNHVFGLLDISSAYCNKTFLA
                     LVLFLQNTKGRMNRSNQFSIYIAVQNIEDWKKGIYYITENGCKLISSDFEIKKFFYDTY
                     DFFEIERSPFTLFVTYTGDGETNQESIYYAHVGAAGLIQYVARYMADGKAYTRPIKNIN
                     DLYCHEKFKTEPNEQVIYAMLFGYNNTGMRKVEGRDFV"
     CDS             3660..4502
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.9e-45, bitscore:
                     146.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNWHSYHLFIHDQACHDLFLKEYLKKFLDKEKGLISKFFFIRYWQ
                     GGPHIRFRFQSHNPEKVLRKLKIVFADFLKNYNPSYRLKKEQYYHNHTFDGELPDEEDM
                     YWVEDGQIVSIPYKPEYERYGGFDIMEVSETIFHHSSQLALQVIEQINDPNVLTKIILA
                     CDFFMLAESQLAYSQRKILNERYHSFWLHFAGESETPIEENLSKIKNAYKARVKKTAPL
                     DLDIYHTFKKVLEEQIRHATAIKPDVNINHLIFSHIHMYNNRIGLPPYYENQIPVIIS"
     CDS             4521..5291
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="PF00881 (E-value: 5.8e-22, bitscore: 70.0,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWNFNQSITYENTLYRKYHLQSNHAPHIQMINAPRREYAIHSLD
                     SVGAKVKYKLKSIENLPSLEVELSEVLKKRRSSWVFSELDLTFEMLEQLLTYSFGISNI
                     REKKRTYPSGGQFYPIEVYFVPTARSVDSNLLEEKVYKYNIDHQEIVEICDFNIDDLKA
                     FSASTDVGFFSIDGCQIVLFLVAEDKDIFVKYLEFTYRIIHLDAGHMAQNFLLTSAALG
                     LSSIPIGGFYEKTVKQILGLDNTSKMIIYTLLGG"
     CDS             5297..6316
                     /locus_tag="ctg16_6"
                     /transl_table=11
                     /translation="MSEKLIKLKENYQIIRNPQNPSQVFVYDKNNEMVFLKFSMSSLEK
                     LEKVDFNRWGQHFQSLQILKSSIEGNIIISLYNRYPDLFISTNNSEDLMIDAKILEREN
                     IINYNHFYSTYQLSNHQYDSSRIFLWGASQTNLLVFHQLMNLSIDVTLIVSLKEKLTPY
                     ENILSGRSPFQQVPDFINSVKDHYNLENKKAKILIFEKIYDFKTLAGKNVIHIVDNKIL
                     DKYVLPELFNRIESSRNKGILYYGSYENELVIGPLVFSGETVSYSDFLFNYDKETKAPS
                     SVLNFLSAGMIQRVISYLNADSLKYLSEDAQLPLNSVFCIDKFSLNSRIIQLKREVLK"
     CDS             6313..7044
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 179.4; E-value:
                     1.5e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_7"
                     /transl_table=11
                     /translation="MKVITQGLNKSYKDKKVLQDISFTIENNEIVAVIGPNGVGKTTML
                     EILMTLKKYDSGDVQILGHNLHKESNIQKVRSKIGVVFQEGGMYAYLKTKEVLDLFASF
                     YDISNDRINEVVNLFSLTKHMNTKYEKLSGGWKKRVLLATAFLNQPELLFLDEPTTGLD
                     PKATKDLWDAIKLAKNNGTTILLSSHSMEEVDMYADRSLILKDGKIAEFDSPTVLKEKY
                     QCTYFKEVYFAILERESSHNE"
     CDS             7037..7774
                     /locus_tag="ctg16_8"
                     /transl_table=11
                     /translation="MSKSLFKLCKYDFVVFLREPFFALPILILPGIFFFVFMSIFKEQI
                     GGAENFGPYIPIYSLLISFLVLFFNIGLQYVTEKERGIHKRLIMSSITIYHVILTYIIR
                     GVLISLIGFIEILLVGKLVFHTILTDHMFLFILTFLIVIGITLLFSLSTHNLFKNSRQV
                     LPYTIVMFQYVLFGSGLMFPIESVPEFVKYIVYINPFYHMKNLLLSVWNWQQIINWQGI
                     AYLVLVIFVCICLIYIKSRSKEY"
     CDS             complement(8266..9798)
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 412.7; E-value:
                     2.5e-125)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_9"
                     /transl_table=11
                     /translation="MEQTAAKDASTKFVVIGLLLGILMSAMDNTIVATAMGNIVADLGS
                     FDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLILFLIGSALCGIAQTMDQLI
                     IYRVIQGIGGGALMPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGALITDSI
                     SWHWVFYINVPIGILSLFFILRYYKESLEHKKQKIDWAGAITLVVSIVGLMFALELGGK
                     TYDWNSVQIIGLFAVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFLYGATF
                     VILAVFIPIFVQAVYGSTATSAGFILTPMMIGSVIGSMIGGIFQTKVRFRTLMLISVVA
                     FFIGMLLLSNMTPDTARTMLTVFMLISGFGVGFNFSLLPAASMNDLEPRYRGSANSTNS
                     FLRSFGMTLGVTIFGTIQTNVFTNKLTDSFSGMKGAGGAMQNIGNPQEIFQAGTRAHIP
                     PHILDRIIDAMSQSITYVFTLALAPIVIAAVTILFMGKARVKTSQEMAKKAN"
     CDS             9912..10373
                     /gene_functions="regulatory (smcogs) SMCOG1135:MarR family
                     transcriptional regulator (Score: 66.8; E-value: 2.4e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg16_10"
                     /transl_table=11
                     /translation="MSTRNTRSETEETAIQLFRKMATRTILFHQAAAQSLGLFPTDLKS
                     ADILNEAGPMTAGELGKKTGLSTGSVTALIDRLEKAGYVMRKKDPEDKRRVIIVPLTAG
                     KANVKQLFSSLSQSTISLCRQYKEEELRLIFDFLGKATDMMEDELEKLK"
     CDS             10437..11066
                     /gene_functions="transport (smcogs)
                     SMCOG1116:Homoserine/threonine efflux protein (Score: 71.9;
                     E-value: 9.2e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_11"
                     /transl_table=11
                     /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGAM
                     AADGLYMILIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGVETLKNIREAMNVRSGKGKP
                     AFYKTFGAGFFISLSNPLSILFWLGIYGSILAKTAESFDANQLLIYSSGILLGILIWDF
                     CMAVAASTFRNLLHETALRWLTGAAGVSLIVFGFYFGWQGIQMLIS"
     CDS             11134..11895
                     /locus_tag="ctg16_12"
                     /transl_table=11
                     /translation="MASELYTKSCLEEKLLDLPNWQRVAFELLSEKVGDKADAFPCIPG
                     RQGFLTDQLRISFAGDPREEGTPEEVGMLLSEYGKISRNTGKYASLLVIFDTPEDLAEH
                     YSVEAYEELFWSFLNRLSGCDPKDWPEDIPEDPEHYKWEFCFDGEPYFILCATPAHEAR
                     QSRSFPFFMLAFQPRWVFEGLNDSTAFGRNMSRLIRKRLEAYDEAPLHPRLGWYGGKDN
                     LEWKQYFLRDDETQVSKCPFSYLKRLFKPTK"
     CDS             complement(11897..13225)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038:phenylalanine-specific permease (Score: 222.8;
                     E-value: 1e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_13"
                     /transl_table=11
                     /translation="MSKSQDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGYSA
                     LISFLIAGLGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGTWAGFSNGWVYWSSEMLIT
                     GSQLTAISLFTKHWFPNVPLWIFASIYAVLGLLIIFTGLSVFQKTENVLAVVKTAAIFM
                     FIVIAILALCGIFSHKPDVQVPNESKDLFPHGAMGLWTGLIYAFYAFGGIEVLGLMTVH
                     LKKPEEASKSGRLMLAVLAVIYVISLGLALLLVPLGKFTEQDSPFITSLKGFHLDIILD
                     IFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFRLKENKKICWPALGLTFAGLI
                     VSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSGKKLLETTKMGTVQIVIALVLIVA
                     AVSGTLFEKSSRPGFLVSLCFLAVIAIVTWIVQKKQGHSPAGS"
     CDS             13350..13946
                     /locus_tag="ctg16_14"
                     /transl_table=11
                     /translation="MTQQFIVPPKKGLGLKVHKGQIIKVVDVEGQQVADFTAYHAKDFY
                     EHLDQGATIDANQSIQVKTGDHIYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLLYG
                     KHKDELQDTCYDNMSGALEPFGVPRPHMHYPFAIFMNTVLDEKGNLSVETPLSDAGDYV
                     RLRAEMDLVVAFSSCPIEKGKCNGDSITALRVEIS"
     CDS             14081..14899
                     /locus_tag="ctg16_15"
                     /transl_table=11
                     /translation="MSIQKQIMNDLHVKPSIDPKQEIEDRVNFLKQYLKKTGAKGFVLG
                     ISGGQDSTLAGRLAQLAAESIREEGGNAEFIAVRLPHGTQQDEDDAQLALKFIKPDKSW
                     TFDIKSAVSAFADQYKKDTGDQLSDFNKGNVKARMRMIAQYAIGGQEGLLVIGTDHAAE
                     AVTGFFTKYGDGGADLLPLTGLTKRQGRRLLEELGAPERLYLKLPTADLLDEKPQQTDE
                     TELGITYNDIDDYLEGKDVSSEVIEALEKRYLSTEHKRQVPASMFDDWWK"
     CDS             15086..15283
                     /locus_tag="ctg16_16"
                     /transl_table=11
                     /translation="MALMPASAFVEIGLFSADADAVGDAAKAGAADISKARDSAEPVNT
                     FLNFISSTPFSNEMCYDVNN"
ORIGIN
        1 cagctaatta tcaaatagat aataacaatg attttaaata tatgagtaca catattaatt
       61 ataaaaaagc tgcattacat actttaatgc acagcataga aaaattctta acttacgaat
      121 ctgagagaaa taaagaaaat actttatgga tagcagatct tgataaagat cgtttttata
      181 taagagggat tgcctcattt ataaagaaag aaagctccat tcatcttatt gaacgaattg
      241 atattacagc aaaaaaattg cttcaaacga tttatcatat gactgaaatt aaagaagtat
      301 taattggaat tgactatttg tttaaaaagg atgtcggcat tgtttatctc attgatgaag
      361 atcattatat cctttataaa agcgaagtaa cgacagattt taatgaatca ataatccggg
      421 gattaacaga gatcataagc aacaaggcaa atggtttgct taaaaaaggt gaatcggttg
      481 aattatccag ctttcaagtc cgagatatcg gtcggaaaag accaaactca ctaatattgg
      541 ctgagatgct tgaagttttt tccgattatg atattaaaga aaaaccatgg atataccaac
      601 cactatttga gtccagtaat ttattaatag gaagttttca attaaccggg gagaatttat
      661 catgatgtac tctataaata aatattacca aaaagttaaa aaagaagata ttcatggtaa
      721 agtcaactat tatgaaactt cttcttatgt ttttatcggt ccgtatgtaa atgatataga
      781 agatccatgc tttaactgct ttaaagaagc ggttaaagca aatgggagca gatattattg
      841 gtgcatagag caggaacgaa ctgagttaac tagctttaac ctatttgcgg atgatgataa
      901 atgtacggaa gaattaaggg gcgcagtact aatttttaat aaaaatacag gaagcattga
      961 aaagaaagaa atttacaaaa atgctttttg tgaaaattgc agttctgatt tctttgagaa
     1021 caaaatactg aaagataatc ataatgaaaa attaaataaa gagggtagag tcgtttcatt
     1081 tactaatgtt attaataagc tgaagaagca tgaaaaactc ttaattgatc aggatacagg
     1141 aataggaaga atgctgttca gagatgcaga atcagatgtt atccctatgt atggtattga
     1201 agcgtatatc ggacaaaggc aatatcattc atatggccgg gcagagagtc taagtgcctc
     1261 taagtattcc gcaatacttg aaatgattga gcgccatgcg agtatgattc cccaattcac
     1321 taaaccgctg cgtgcttctt atcatcaact gaagcaaaag aaaatggatg taattaatcc
     1381 tgaatctttt attttgcata aaagtgttga aggagaacat ttatattctc atgataagga
     1441 aatttattgg acagcgtgcc gacgtttaga taacaataaa gaagttttaa ttccagagca
     1501 gttaatttat tttgataacc aaatcatacg tggagaaaat cgatttatat atgagacatc
     1561 aaatggggca gctcttggga acagtatgaa agaagcagtt atgtacggat tgtttgaggt
     1621 aattgaacga gattgttttt tggttcattg gtattgcaaa aaaacaccta aaagaataga
     1681 cgtttcatca tcaaataatt tacaaatcaa acttgtttta aaacaacttg acgatttggg
     1741 ctatgacgtg cacctttttg atattactct agaaactgat atccccgctg tatgggttct
     1801 tgcagtaaac cgtaaggatg gtgcgaattt aaagtattac aatgcagcag gagctcacta
     1861 caatccagaa aaagctattt tttctggttt agtagaggta gccacatctg ctttaattta
     1921 tgaaaaaaaa cttgataagg agaaatccca tttaaattac ttaatacaaa atccaagtgg
     1981 cgtaaaaaag atggaggacc atgttaatta ttattccttt gaagaaaatg gcaaagcttt
     2041 tgattttctt ctgaataatc tggagcaaat ggagctaata gaagtgcata aaatgactcc
     2101 agcatttcca tttacgtatg atgcacttaa aagagcggta ttagataagc accctgatat
     2161 ttacatagct gatttaactc aatatttaac tgaaaaatta gattttcacg ctgtgaaaat
     2221 tcttatccca agtttgcaac cgatgacttt tggacttcaa aatgagcgtc tgaatttgga
     2281 aagacttaat caatattgcg aagatctatc gcttttaaaa aataaggaaa gagagccgca
     2341 tccattccca tgagtattac tcttaatgac cttactttta atagatatga aaagaaccgt
     2401 aaatctttgt cttttcaatt tgtttcacca agaggcactt catttaaata tgaaaaggac
     2461 cagaaaagaa actctcatca aaataaacct ttccgaaaac tggccctatt tgttgaagag
     2521 ttgtttcgat ttcagagtta tgaataccaa agtccttact catttcataa atatgccccc
     2581 tcagctagag gaatctattg tttataccct tatgtcatct gtatgggata tgtatggctt
     2641 tatgatgctc tggaccatag atgggtgtgt attggatatg tcccttctaa agttcaagct
     2701 gtcgagctta tcatctcttg tgatttctgg aggttatgct ctgtttatgg aagttttggg
     2761 cttgcactag gattgttaga acttggacat atgacagcag atattaaaat ggattccgaa
     2821 gatcatggtt ttcctgttaa aaaggttggc tacatgttta accgttggca ttattcaaaa
     2881 atactgaagg ctcctgaaga tattcttctt ggatgtctaa tagagtttga gcagtcaaag
     2941 ccgattgatc agcctgacgt acgccacaat atttataagt ataaaaagac ttataactat
     3001 caaaaagaac ttcttcaaat tggcattatg gactacataa atgctttgac taaaatggat
     3061 gaaagtctta aaaataatga ttggttttac gaggagtctt caaaaggtaa taaagctcac
     3121 agacattcag gtaaccatgt atttggctta ctggatatta gctctgctta ttgtaacaag
     3181 acttttttag cactcgtttt atttttgcaa aatactaaag gaagaatgaa taggtctaat
     3241 cagttttcaa tttatattgc tgttcagaat atagaagatt ggaaaaaagg tatttattat
     3301 ataactgaaa acgggtgcaa attaatatca tctgattttg aaataaaaaa attcttttat
     3361 gatacatacg atttctttga aatagaaaga tctcctttca cactatttgt tacatatact
     3421 ggtgatggag aaacaaatca agaaagtata tattatgcac atgtgggagc agctggcctt
     3481 attcagtatg ttgctaggta tatggcagat gggaaggctt atacaaggcc cattaaaaat
     3541 ataaatgatt tatactgcca cgagaaattt aaaaccgaac ctaatgaaca ggtcatttat
     3601 gctatgcttt tcggttacaa caatacaggt atgaggaaag ttgaggggag agatttcgta
     3661 tgaattggca ttcttaccat ctgtttattc atgatcaagc atgtcatgat ctttttctga
     3721 aagagtattt aaaaaagttt ttagacaagg aaaagggttt aataagtaaa ttttttttta
     3781 taagatattg gcaaggaggg ccgcatatta ggtttcggtt tcaaagccac aatcctgaga
     3841 aggtactaag aaaattaaaa attgtatttg ctgatttttt aaaaaactac aacccttcct
     3901 ataggttaaa aaaggaacaa tattatcata atcatacatt tgacggagag ctgcctgatg
     3961 aagaggatat gtattgggtg gaagatggtc agatagtttc tattccttac aagcctgagt
     4021 acgaaagata cggaggcttt gatattatgg aggtttctga gacaattttt catcattcaa
     4081 gccaattagc cttgcaggtt attgaacaaa taaatgatcc taatgtgtta acaaagatta
     4141 tcttggcttg tgattttttt atgttggctg aaagtcagtt agcatatagc cagcgcaaga
     4201 tattaaatga aagatatcat tcgttttggc tgcactttgc aggtgaaagt gaaacaccca
     4261 ttgaagagaa cctttcaaaa ataaaaaatg catataaagc gagggtaaaa aaaacagccc
     4321 cattagatct cgatatatac cataccttta aaaaagtttt agaggaacag attcgacatg
     4381 ctacagccat aaaaccagat gtaaatataa atcatttgat tttttcacat attcatatgt
     4441 ataacaatcg tattgggttg ccaccttatt atgaaaatca gattcctgtt attatttcat
     4501 agactggagt gatgtaaaaa atgaaatgga acttcaatca atcaattact tatgaaaata
     4561 cactttacag aaaatatcat ctgcaatcaa accatgcccc ccatattcag atgataaatg
     4621 ccccaagaag ggaatatgct attcattcct tagacagtgt tggtgcaaaa gtgaaatata
     4681 agttaaaaag tatagagaat ttgccttctt tagaagtgga attatcagaa gtgctaaaaa
     4741 aaagaagatc ttcctgggta ttttctgaac tggatttaac ttttgaaatg ttagagcagt
     4801 tattgacata tagctttggt attagtaata ttagggaaaa aaagcggaca tatccctctg
     4861 gtggtcaatt ttaccccata gaagtctatt ttgtgccgac agcaagaagt gtagatagca
     4921 atttgttaga ggagaaagtg tataaatata acatagatca tcaagagatt gtggaaatct
     4981 gcgattttaa tattgatgat ttaaaagctt ttagtgcatc tactgatgtg ggtttttttt
     5041 ctattgatgg atgtcaaatt gttttatttt tggtagctga agacaaggat atatttgtga
     5101 aatatcttga gtttacatat agaattattc atttagatgc tgggcatatg gctcaaaatt
     5161 ttttacttac cagtgctgct cttggacttt caagtattcc tataggaggc ttttatgaaa
     5221 aaacagtaaa acaaatactc ggtttagata atacgtcaaa aatgattatt tatacactct
     5281 tagggggata atctgtatgt ctgagaagct cataaaactt aaagaaaact atcaaatcat
     5341 acgaaatccg caaaatccaa gtcaagtatt tgtttatgat aaaaataatg aaatggtttt
     5401 tttgaaattt agcatgagtt cattggaaaa attagagaaa gtagatttta atcgctgggg
     5461 gcagcatttt caatcacttc aaatattaaa atcctctatt gaaggtaata taatcatttc
     5521 attatataac agatatccag atttgtttat cagtactaat aatagcgaag atttaatgat
     5581 tgatgcaaaa atactggaga gagaaaacat tattaattat aatcactttt atagtacata
     5641 tcaattatcc aaccaccaat atgattcatc tcgaattttt ttgtggggag cttcccaaac
     5701 aaatctactt gtttttcatc agctcatgaa tctctcaata gatgtcacac ttattgtatc
     5761 gttaaaggaa aaattaactc catatgaaaa tattctttca ggcagaagtc catttcagca
     5821 agtgccggac tttataaata gtgtgaaaga ccattataac ctggaaaaca aaaaagcaaa
     5881 gattttaatt tttgaaaaaa tatatgattt taaaacatta gcaggaaaaa acgtgattca
     5941 tattgttgac aacaagatac tagataaata tgttttgcca gagctattta atagaatcga
     6001 atcctcaaga aataaaggta ttctatatta tggttcttat gaaaatgagt tagtgatcgg
     6061 tcccttagta ttctcaggtg aaactgtttc ttattccgat tttcttttta actacgataa
     6121 agaaacaaag gcgccatctt cagttttaaa tttcttatct gcaggaatga ttcaacgggt
     6181 tatctcatat cttaatgctg attcattaaa gtatctgtct gaagatgctc agcttccctt
     6241 aaattctgta ttttgcattg ataagttttc tcttaactct aggataatcc aattaaagag
     6301 agaggtttta aaatgaaagt tattactcaa ggtttgaaca aatcatataa agataaaaaa
     6361 gttctgcagg atattagctt cactattgaa aataacgaga ttgtggcagt aataggccct
     6421 aatggggttg ggaaaacaac catgttagaa attttaatga cattgaaaaa atacgattca
     6481 ggtgatgttc aaatattagg tcataactta cataaagaat ctaatattca aaaagtgcgt
     6541 tcaaagatcg gagttgtttt tcaggagggg gggatgtatg catacctaaa aacaaaagaa
     6601 gtgttagact tattcgcctc gttttatgat atatctaatg atagaatcaa tgaagttgtt
     6661 aacttattct cgcttacaaa acatatgaat acaaagtatg agaaactatc ggggggttgg
     6721 aagaaaagag ttttgttagc tactgcattt ttaaaccagc ctgaattact ttttctggac
     6781 gagcctacaa cgggacttga tcctaaagcg acaaaagatt tatgggatgc tattaagttg
     6841 gcgaaaaata acggaacaac aatcttattg tcttctcatt ctatggaaga agtggatatg
     6901 tacgcagacc gctctcttat tctaaaagat ggcaaaattg cagaattcga ttctccaaca
     6961 gtgttaaaag aaaagtatca atgtacgtat tttaaagaag tgtattttgc tattttagaa
     7021 agggagtctt cacataatga gtaaatcttt atttaaatta tgtaaatatg attttgttgt
     7081 ttttttacgt gaaccttttt tcgctttacc aattcttata ctgcctggga ttttcttttt
     7141 tgtctttatg tctattttca aagagcagat tggaggagct gaaaactttg gtccgtatat
     7201 tccaatttac agcttattaa tctcatttct cgtattgttt tttaatattg gtcttcaata
     7261 tgtaacagaa aaagaaagag gaattcataa acgtttaatt atgtcttcta ttacaatata
     7321 tcatgtaatt cttacatata ttattagagg ggttcttatc tcgttaattg gttttattga
     7381 gatattgctt gttggtaaac ttgttttcca tactattttg acagatcata tgtttttatt
     7441 cattctaact ttcctgattg taatcggtat aaccttgttg tttagtttat ctactcataa
     7501 tctctttaaa aattcaaggc aagttcttcc ttatacaata gtcatgtttc aatatgtatt
     7561 atttggatcc ggacttatgt ttcctattga gtctgttcct gaatttgtta agtatattgt
     7621 ttatataaac ccattttatc acatgaaaaa tttgttgtta tctgtgtgga attggcaaca
     7681 gataatcaac tggcaaggga tagcatattt ggtattggtt attttcgtat gtatatgctt
     7741 aatctatata aaatcgcgtt ctaaggaata ctaaattaaa gaattgtgta ttggctgttt
     7801 tagcggctta aaatttacac tataaaaaag caggattgtt tagaggtatt atactcccct
     7861 tagacaggca gatgttatcc taatctgcct gcctaagggg agtattttcg ataactatta
     7921 tctataaatt caaagcccga caaatttgct tagtggacat tattctcaat tagaaatgat
     7981 atacgagtgt ctaatatcca gttcgtcaat gtcaggaaaa tcgatgaaaa aggatagtca
     8041 taaagcagcc atgaacgaat ggttgcccta tgacaaaggg tagttcaaca atttgcttac
     8101 tataagttaa atagcatttc ttcccttata aagtttaagt atagaaatgt tgattgcata
     8161 agtatcaggc atttaatgaa ctcacctata agtgggtaaa tactatacta ttccatctct
     8221 acttgatagg ggataattaa gtttcactaa acccgatctt cttcgttaat tcgctttttt
     8281 cgccatttcc tgagaggttt ttactctcgc ttttcccata aacaaaatgg taacggccgc
     8341 aatgacgatc ggcgccagcg caagcgtaaa tacatatgtg atgctttgcg acatggcgtc
     8401 aataatgcga tccagaatgt gcggcggaat atgagcgcgc gtgccggcct ggaaaatctc
     8461 ctgcggattt ccgatgttct gcatcgcgcc gcccgctcct ttcatgccgc tgaatgaatc
     8521 tgtgagcttg ttagtaaaca cattcgtctg gatggttccg aaaatcgtca caccgagcgt
     8581 cataccgaat gatctcaaaa acgagtttgt tgagttggcg cttccgcggt aacgcggctc
     8641 cagatcgttc atggacgcag ccggcagcag tgagaagttg aagccgacgc cgaatccgga
     8701 gatcagcatg aataccgtca gcatcgtacg cgccgtatcc ggtgtcatat tggaaagcag
     8761 cagcattccg ataaagaaag cgaccacgga aatcagcatt aaagtgcgga accgcacttt
     8821 tgtctggaaa attccgccga tcatacttcc gataacagaa ccgatcatca tcggcgtcaa
     8881 aataaagccc gcgcttgtcg cggtgcttcc gtacacagcc tgaacgaaga tcgggataaa
     8941 caccgctaaa atgacgaacg tggctccgta aaggaacgcc agaatctgtg ccgtagcaaa
     9001 taaacggttt ttaaacatcc aaaatgagat aatcggttct tccgcttttc tttccacaat
     9061 aaaaaaggcg ataaagaaca cggcgaacac agcgaacaga ccgatgatct gcacggagtt
     9121 ccaatcatac gtttttccgc cgagctcaag agcgaacatc agaccgacaa tggaaaccac
     9181 cagcgtgatt gcgccggccc agtcgatttt ctgcttcttg tgttcaaggg attctttata
     9241 ataacgaaga atgaaaaaca atgataaaat accgatcggc acgttgatgt aaaacaccca
     9301 gtgccagctg atggagtcgg taatgagcgc gcctaaaagc ggcccgagaa cgctggacag
     9361 gccgaaaacg gcaccgaaca tgcccgacat ttttccgcgt ttttccggcg gaaataaatc
     9421 aaaaatgatc gtgaaggcga tcggcatcag cgcgcctccg ccgattccct gaatgacgcg
     9481 gtaaataatg agctgatcca ttgtttgggc gattccgcat aacgcggatc cgattaagaa
     9541 aagaataaga ccgaataaaa agaaacgttt gcgtccgtac atatcggaca gttttccgta
     9601 aatcggcata ccggccataa cggctaccat gtatgatgcc gtcacccacg cgaacttatc
     9661 gaaacttccg aggtccgcca cgatatttcc catcgcagtg gcaacgattg tattatccat
     9721 agccgacatt aaaatgccca gcaaaagacc gatgacgaca aacttcgtcg aggcgtcctt
     9781 cgcggctgtt tgttccatgc tttttcctcc catacttact tttgatcatt aaatttgcta
     9841 tgatcatatt agatttgccg aaaattatct tgatcgtcaa gataaattga ttttataggg
     9901 aggcctgtca gttgtcaaca agaaatacca gaagcgagac ggaggaaacc gcgatacagt
     9961 tattccgaaa gatggccaca aggacgatcc tttttcatca ggcggccgct caatctctcg
    10021 gtctgtttcc gaccgatttg aaatcagctg atatcttaaa tgaagcaggc ccgatgaccg
    10081 caggcgagct tgggaaaaaa accggcctca gcacaggttc ggtaacggcg ctcattgacc
    10141 ggctcgaaaa agcgggatat gtcatgagga aaaaagaccc cgaagacaaa cgtcgggtga
    10201 tcatcgtgcc gctgacagcc ggaaaagcga atgtgaagca attgttcagc tccttatccc
    10261 agtccacgat cagcctttgc cggcaatata aagaagaaga actgcggctg atattcgatt
    10321 ttttaggaaa agcgacggac atgatggaag acgagcttga gaaattaaaa taatatatca
    10381 tagcacggcc cattcatgaa taacttgtac aagttgcatg aatgaggggg aagccaatga
    10441 acatcttttt aagctacatc gttctcgggc tgtcattgtc agcacctgtc ggaccggtca
    10501 atgcggcgca aattgacaaa ggcatcaaaa acggcttttg gcatgcatgg attttcggtc
    10561 ttggcgccat ggccgcggac gggctgtata tgattctgat ctatttcggg ctgtctcaat
    10621 ttttgacggc gcctttcgtt aaaacgtttt tgtggctctt cggttttttc gtgctgacct
    10681 atacgggagt cgaaacgtta aaaaatataa gggaagccat gaatgtcaga agcggaaaag
    10741 gaaaaccggc tttttacaaa acattcggcg cgggattttt tatttctctt tccaatccgc
    10801 tgagtatttt attctggctc ggcatatacg ggagcattct cgccaaaacc gctgaatcct
    10861 tcgatgcaaa tcagcttttg atttacagct ccggcattct tctcggcatt ttgatctggg
    10921 atttttgcat ggcggtcgct gcgagcactt tcagaaatct tcttcatgaa acagcgcttc
    10981 gctggctgac gggagcggcg ggtgtgtctt tgatcgtttt cggattttat ttcggctggc
    11041 aggggattca aatgctcatc tcataaatag aaggactgtc acccatcgcc tgtctccatc
    11101 ataacgtatc ctgacgatac tggaggtggg ctgatggcaa gcgagctgta cacaaaaagt
    11161 tgccttgagg aaaagttgtt ggatctgcca aattggcaga gagtcgcttt tgagcttcta
    11221 tcagaaaaag taggtgataa agcggacgcg tttccgtgca ttccgggacg tcagggattt
    11281 ttgacagatc agctccggat atcctttgcg ggtgatcccc gcgaagaggg aaccccggag
    11341 gaagtgggga tgctgctgtc cgagtacgga aagatctcaa ggaataccgg aaaatacgcg
    11401 tcgctgcttg tgatttttga tacgcctgag gatttagctg agcattattc cgttgaggcg
    11461 tatgaagaac tgttctggtc ttttttaaac cggctgagcg gctgcgaccc gaaagactgg
    11521 ccggaagaca taccggagga ccctgaacat tataaatggg agttctgctt tgacggcgag
    11581 ccgtatttta ttctgtgcgc gacgcctgcg catgaagcga gacaaagcag aagcttcccg
    11641 ttttttatgc tggcgtttca gccgagatgg gttttcgaag gattaaatga ttcaaccgcc
    11701 ttcggacgaa acatgagccg gctgatcaga aaacgcttag aggcgtatga tgaagcccct
    11761 cttcatcccc gattggggtg gtacggagga aaagacaatt tagaatggaa gcaatatttc
    11821 ctccgtgatg atgagacgca agtgtcaaag tgtccctttt cttatttgaa gagactgttt
    11881 aaaccgacga aataagctat gatccggcag ggctgtgtcc ctgctttttt tgtacgatcc
    11941 atgtcacgat cgcaatgacg gcgagaaaac aaaggctgac cagaaaaccg ggccggctcg
    12001 atttctcaaa cagcgtcccg gagacggccg caacaatcag cacaagggcg ataacaatct
    12061 gaacggttcc catctttgtc gtttcaagca gtttcttgcc cgagaacaaa atgaacagcc
    12121 acgtataaag aagcatcagg cccgccgcgg ttgtcatgtg ttcatatata tttttcggca
    12181 gcaccaatga caggatgatg gagacgatga gtccggcaaa cgtcaatccg agcgcaggcc
    12241 agcagatttt tttgttttcc tttaatctga agcatttcgg cgcatccccg tcatcggcca
    12301 tcgtacaaag caatgtcgtc acggcaaaca gcgaggcgac gagcgtggaa aatcccgcaa
    12361 taataaaaat cccgttaaaa atatcaagaa tgatatctaa atgaaaaccc ttcagcgatg
    12421 taataaacgg gctgtcctgt tcggtgaatt tgcccagcgg cactaacagc agcgccaggc
    12481 cgagagaaat gacgtaaatc accgcaagaa cggcaagcat cagccggcct gattttgagg
    12541 cttcctccgg ctttttcaaa tgcacggtca tcagccccaa gacttcaatt cctccaaagg
    12601 cgtaaaatgc ataaatcaat cccgtccata accccatcgc tccgtgcggg aacaaatcct
    12661 ttgattcgtt cggcacctgc acatccggtt tatgagaaaa tataccgcac agcgccaata
    12721 tggcgatcac gataaacata aaaatcgccg ctgtcttgac aacagcgagc acattttccg
    12781 ttttttgaaa aacggacagc cccgtaaata taatcaaaag accgagcacc gcatagatgg
    12841 aggcgaaaat ccacagcggc acattcggaa accaatgctt tgtaaacagc gagatcgctg
    12901 tcagctggct tccagtgatc agcatctcgg acgaccagta cacccatccg ttgctgaaac
    12961 cggcccaagt gccgaaagcc tttctcgcat aagcgcaaaa agaccccttt tcgggctgtt
    13021 tggccgagag cttcgcgagc tgctcaaaga caaaataggt gccaagcccg gcaataagaa
    13081 atgagatcag cgcggaatat ccgcttttga caatagcgat gctggacccg agaaaaaagc
    13141 ccgtcccgat tgtgcagccg acgccgatta aggagagctg ccaccaagcg agattccctt
    13201 taggctggtc ctgtgattta ctcatgaagt tcaacccctt tatcaaagct tagattgcgg
    13261 ccgtcagaag gggaatatac atccaataaa ttgctttaca tgaaacaaac ggccgaagtt
    13321 cataatagaa gaaaaaaagg agcagtctga tgacacagca atttattgta ccgccgaaaa
    13381 aagggctcgg cctgaaggtt cacaaagggc agattataaa agtagtcgat gtggaagggc
    13441 agcaggtggc tgattttacg gcgtatcatg ccaaggactt ttatgaacat cttgatcagg
    13501 gcgcgacgat tgatgccaac cagtccattc aagtaaaaac gggtgatcat atttattcga
    13561 atttatacaa gccgatgctg acgctgattg aggatacagt cggcaagcat gacctgctgc
    13621 ttcccgcctg ccgtccggat atgaacaggc ttttatacgg aaagcataaa gacgagctcc
    13681 aggatacgtg ctatgacaat atgagcgggg cgcttgaacc gttcggggtg ccgcggccgc
    13741 atatgcatta cccatttgcc atctttatga acacggtgct cgatgagaag gggaacttat
    13801 cagtcgaaac gcctctttct gacgcgggtg attatgtacg gctccgtgcg gaaatggatc
    13861 tcgtcgtggc gttttcatcc tgtccgattg aaaaaggaaa atgcaacgga gacagcatca
    13921 cggcgctgcg ggtggaaatc agctgatccc ggtgtatttg attcacttaa aatctgcacc
    13981 tgtgctatat ttaacagaga gtcgtacata gtggcatgat tcattttcag catgaacggg
    14041 aaatggatca taaagaaaca atgcaggagg agtgattggg atgagcatcc agaaacaaat
    14101 tatgaatgat ctccatgtaa agccctcaat tgatccgaaa caagaaattg aggacagagt
    14161 gaactttctg aaacaatatt tgaaaaaaac aggtgccaaa ggctttgtgc tcggcatcag
    14221 cggggggcag gattccacgc ttgcgggacg cctcgcccaa ttggcggctg aaagcatcag
    14281 agaagaaggc ggaaacgctg aatttatcgc cgtccgtctt ccgcacggca cacagcagga
    14341 tgaggatgac gcccaattgg cgctcaaatt cattaaacct gataaatcat ggacatttga
    14401 tattaagtcc gctgtcagcg cgttcgctga tcagtataaa aaagacacgg gcgatcagct
    14461 gtctgacttt aacaaaggaa atgtaaaagc cagaatgaga atgatcgctc aatatgccat
    14521 cggcggacaa gaggggctgc ttgtcatcgg aaccgaccat gcggccgagg cggtgaccgg
    14581 tttcttcacg aaatacggtg acggcggagc tgatctgctg ccgctgaccg gattaacgaa
    14641 acgccagggc agacgtttat tagaagagct cggcgcgccg gaacgcctgt atttgaaatt
    14701 accgacggcc gatctgcttg atgaaaaacc gcagcagact gatgagaccg aactcggcat
    14761 cacatacaat gacattgatg attatttaga aggcaaggat gtttcttccg aagtgattga
    14821 agcgctggaa aaacgctacc tcagtacgga gcataagcgc caggtgccgg catcaatgtt
    14881 tgatgattgg tggaaataga atgaaaaaaa cctccctttt gaaagggagg ttttttgttt
    14941 atttcatttt tatttatcta cactttcata aatccctacc caataccctt tgctgctgtc
    15001 atagtatttg cttttgaaaa tccattttgt tccatctaaa acgaaagaag cagcgaaatt
    15061 gccgttaggg ctttgaacga gtttgatggc attaatgccg gcatctgctt tcgttgagat
    15121 tgggctattt tccgcggatg cggatgctgt tggtgatgcg gcaaaggcag gagcggcaga
    15181 catcagtaag gcaagagaca gcgcagaacc ggttaacact tttttgaatt tcatttcgag
    15241 cactcccttt tcaaatgaaa tgtgttacga tgttaataat tagataatta t
//
