LOCUS       gnlProkkaMHAGGBEP_1    13792 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MHAGGBEP_1.
ACCESSION   gnlProkkaMHAGGBEP_1
VERSION     gnlProkkaMHAGGBEP_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 09:17:16
            Original ID  :: gnl|Prokka|MHAGGBEP_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 5974558
            Orig. end    :: 5988350
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13792
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8792]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8792
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13792
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13792
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(663..1436)
                     /locus_tag="ctg1_5110"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKILNNEEYLYYW"
     CDS             complement(1582..1746)
                     /locus_tag="ctg1_5111"
                     /transl_table=11
                     /translation="MITDYTSTYFDFLLVNKPVIFNFYDIEEYRRVRGFSFEPIEFFVQ
                     VILFTIIMN"
     CDS             complement(1743..2366)
                     /locus_tag="ctg1_5112"
                     /transl_table=11
                     /translation="MLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDY
                     HMGDHSYDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNN
                     CNVIKREISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFN
                     AALILKLHPLQNKTVLKKIYPKVYLFLNKHINMDCMIFCHFQME"
     CDS             complement(2440..2700)
                     /locus_tag="ctg1_5113"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKIVLNIIKYMLKFMILLVFQNIKNIFMA"
     CDS             complement(2654..3814)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_5114"
                     /sec_met_domain="Polysacc_synt (E-value: 2.4e-12, bitscore:
                     45.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAA
                     FISGVIGIWMAYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFG
                     SKLLISSLINTVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPIL
                     SSIQDDDKCLTNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILC
                     LDWMFDHLSQINLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYS
                     LIATYLNTYYTNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCI
                     TGMSFYILLSFLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             complement(3832..4137)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_5115"
                     /sec_met_domain="Polysacc_synt (E-value: 2.8e-06, bitscore:
                     25.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKIELKRILPLSFILIFLSQYYSMVYCFFRLL"
     CDS             complement(4340..4483)
                     /locus_tag="ctg1_5116"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(4480..5004)
                     /locus_tag="ctg1_5117"
                     /transl_table=11
                     /translation="MTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFT
                     PPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVS
                     VQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAA
                     LNHYNVTLPMS"
     CDS             complement(5001..5600)
                     /NRPS_PKS="Domain: Aminotran_5 (29-195). E-value: 4.9e-25.
                     Score: 80.0. Matches aSDomain:
                     nrpspksdomains_ctg1_5118_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 59.4; E-value:
                     4.9e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5118"
                     /sec_met_domain="Aminotran_5 (E-value: 4.5e-21, bitscore:
                     73.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKDFKR"
     aSDomain        complement(5016..5513)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_5118_Aminotran_5.1"
                     /evalue="4.90E-25"
                     /label="ctg1_5118_Aminotran_5.1"
                     /locus_tag="ctg1_5118"
                     /protein_end="195"
                     /protein_start="29"
                     /score="80.0"
                     /tool="antismash"
                     /translation="CPREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDIC
                     LNSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPD
                     IAMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMAS
                     AQK"
     CDS             complement(5610..6734)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5119"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.7e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4e-18, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(6751..8052)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5120"
                     /sec_met_domain="CTP_transf_like (E-value: 8.5e-11,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 8.8e-119, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.9e-61, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8073..8792)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5121"
                     /sec_met_domain="NTP_transf_3 (E-value: 7e-14, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(8856..10004)
                     /locus_tag="ctg1_5122"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10015..12384)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 6.8e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_5123"
                     /sec_met_domain="Poly_export (E-value: 4.6e-16, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQKQLASELARKGVTK
                     EQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLEDHPTTQDLARGDQVF
                     GRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIRQQISPEGTINIQKI
                     GPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNIRTIQINVMGEVVQP
                     GTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRL
                     QEGDVVIVPAYDVLVKISGKVKRPMRFEMKKEENLATLIKYAGGFEADAYTRSLRVVRQ
                     NGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNT
                     IRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYI
                     PSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDISRRIKN
                     PRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEIL
                     FGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLG
                     EAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMV
                     PNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIV
                     PGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(12822..13400)
                     /locus_tag="ctg1_5124"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 tttccgctcc catcgctaca gcagctgtag cagcagaaat acctattgta tgatcagaaa
       61 aacctatctc aaacttattg taatgcttct tcaaatatgt tattgtacgt agattcaaat
      121 tatttggatg agttggatac tgagatacac aatgtagaat agctatatta ctatgatatc
      181 tcgttatcac atctaatgca ttgtcaagtt ctctttgacc agccattcct gtcgataata
      241 taataggaat atgagtttct gctaatgctt caagcaatgg taagttagtc aaatcacgac
      301 tagcaacttt tagcctatcc ggtgtgaaca gtttaagcaa agacagacat cctttggcac
      361 ataacgtctc gataaaatct aatcctaatg acttagcata tttataaatc tcaaaatgcg
      421 cttgatcatc aagctcaaga aaagcacgat gttcaccata agtacgccca aaagaattag
      481 gattgtcata tatttgattc atttgagaaa cagccaattc ttctgataaa tctcttttag
      541 tcattttaac agcattcatt ggcatgaaat ccataccaaa aacatcctca tgtacaggtc
      601 gtgagattaa ttcaataatc aacttagcca agtcaacaga accattatga ttctgcccta
      661 tttcaccaat aatataagta ttcttcatta tttagaattt tttttatttg ttgtttcatc
      721 agttgaatgt attctgcatg tcttcgaaca tagtctacaa tcacttctat cgatatttcc
      781 actctttttt cttgtaaatc cctatatatt ctctgtgcta cagaaaaatc ttctaacgta
      841 tcaatcgtga gtcgaatatt atgatgtttt gacacgactg gagatcctga aatccattga
      901 atattaaaaa gttcaggatg actatatata taattagtaa catgttcacg atacaataaa
      961 tcatcagtaa atcctataac tcgcttcagc gcatcaagcg ttacaaattc tccccaaaaa
     1021 ccgaaatgag ttttaattga tggagtacca tcaatatcaa aacttatata atcgttacaa
     1081 gatttcattg ctatttcgac caattgcctt gccgcatgta catctaaaaa tggattatca
     1141 gaacatattc ggaatatacc ctgtatatca aaatattcag caacatcaat gaatcgtttt
     1201 aaaacatcat tctcctcacc tctgaagcac tttaccccta atgcaagtgc cttcttttca
     1261 ataggttcat tgataacaga atttgttgta gcaataatta ctggaatatt cgatatagca
     1321 gaaagcttat gaaccattaa gtcaagaatc gattgattac catagaaagg tttcaatatt
     1381 tttccaggca aacgtgtaga acctaaacgt gcctgcacca caaatgcata attcatttta
     1441 tttattatat ttcatttaaa aatatgtcac atattctctt tgttgaatta tcatcttgaa
     1501 attgattcat caataaagaa atatgacgtc gatgttcagc atgaatatct ttcccagcca
     1561 gaagtcccat cacagcatct atcaattcat tataattgta aacaatatca cctgcacaaa
     1621 aaattctatt ggctcaaatg agaaacctct tactctacga tattcttcaa tatcgtagaa
     1681 attaaatatg actggcttat ttaccaataa aaaatcaaaa taggtagaag tataatcagt
     1741 aatcattcca tctgaaaatg acaaaagatc atacaatcca tatttatatg tttgttcaaa
     1801 aacaagtata cctttgggta aatctttttt aagactgttt tattctgcaa aggatgtaat
     1861 ttaagaatta aagccgcatt aaacttcaat agtattttcg ataacttcaa caaatcacaa
     1921 tcaacatatc cgagtattga acgcaaatta ccttcagtaa cagtctcata atcacgaaaa
     1981 gttggagtat aaactatata tttagttaca tcatatcccg caaatttcga aatttctctt
     2041 ttaataacat tgcaattatt tttcgatatc aacaaatcat ttctgggaaa tcctaagact
     2101 ttgaatttat catatgagat tccacaatct attgaaatta ttctagcact taaacaagaa
     2161 gtagcaatag agtaatcaaa tgagttacat gttgtattac gaaatttatc ataagaatga
     2221 tctcccatat gataatcatc tttgaatgga gtataatacc ccaaacaaat aatctgttga
     2281 gagcgttttt taaatgaaaa atcataataa aaagtagctg taaaacattt acttgctcta
     2341 caaaaacaaa aaaaggcata caacatatcc ttaaaagata ctttattaaa gaaaaaacgt
     2401 ccaacacatg cacataaaaa gtacacctaa tattaggatt tatgccataa atatattctt
     2461 gatattctga aatacgagaa gaatcataaa tttcaacata tattttataa tattcagcac
     2521 tatctttttt agcaaataat ttaacagaac gagaacatta tctgacgaat aatttataat
     2581 atcatattta tctgttctac aattaggatg aggaataaaa tacaatgatc tactatcaac
     2641 tggcacacaa tggttaatta tctttactat tacttgaaaa atctttttta atattttcat
     2701 ctatgttttt agttttaatg atcaatgtta aaatacaaaa aaaagaatct agcttaaaaa
     2761 gaaaagaaag taaaatatag aaggacatcc cagtaataca tccaatcaca atttttacta
     2821 tatcagtttc aaagaaagaa atacatataa aaacgatccc ccccattatg aaagagagta
     2881 ttaaacttgg aaatacatct ttaacttgca actttaaggt caaatcaata agagaattag
     2941 tataatatgt attcaaatat gtcgctatca gagagtaaat aactctaccc caacacatca
     3001 cctcaagccc aaatggaatt gacacaaaaa gaatgaatat agcaatcgtc ttttttatta
     3061 tttcaagacg taacgacaga tcagatcttc ctttaaccca taataaattc aaattaattt
     3121 ggctcaaatg atcaaacatc caatccaaac ataatatctg taaaagaata acaaccccag
     3181 accatttatc tgttaacaat agactaataa taggattagc caaaacaagt aaacctacca
     3241 ttaaaggaaa aattatatat gaggataatc tgatataatt tcgatatgcg tttgttaaac
     3301 atttatcatc atcttgaatg gaacttaaaa taggatacgc tactctagaa actaaagcat
     3361 ttaaattatt ggaaggaaaa atagcaaatt gttctgctct tgtatagtaa ccaagctcta
     3421 caacagaaaa cttttttcct attacaatgg tatacagatt acgatatact gtattgataa
     3481 gacttgagat caataattta gatccgaaat tgaataatct ttcaaaagaa cttttggaga
     3541 aagtatgtaa aggtttccaa tgaactaaac agtaaaacaa aattgtcaaa attatactat
     3601 ttaagagagt ttgccaaact aaagcccaaa ccccgcaacc gacataagcc atccatattc
     3661 caatcacgcc tgatataaaa gctgcaccta atgaaatttt agattgagtt ttaaagttta
     3721 cagaaataat taatttcgtt ctgtgaatag ccgataaagc atttattatc aacgacaatg
     3781 ctataaaacg aattacaaga actaaagtcg gcatattata aaagtctgca atcaaagaag
     3841 ccgaaaaaaa caatatacca tagaataata ctgcgacaag aatattaaaa taaaagacag
     3901 tggcaaaatc ctcttcagtt ctatcttttt ctggattaaa gcatttgtaa aaccgctatc
     3961 tataaatact tgagcgactt gaagaaaaat agctaacatc ccgatcatac cataatccga
     4021 tggtagtaac aaacgagcta atattatttg aattataaac tgtactcctt gtaaagagaa
     4081 acgttctata gcgctccaca ttattcctga tacagttttc tgctttagat tttccattac
     4141 ttaaatacag tataaaaaca actacattta ccgatatcaa ttatattttt ccaatattct
     4201 cactaattgg ttattatctt cttcgcccct taccgcaatt ctaatatggt ctctcccact
     4261 aaaagcaaat taccctacac aaacattatc tcctataact accgatgcct ttttataaga
     4321 ataaagaact cctaatgcat cacctcaaat taatattgcc atatttgcct actaagcgaa
     4381 agctacgaat aggcactcca gaaataacac tttccggatg gaagtgtata ccacgaaggg
     4441 aaaaataaaa atgacgaatc ttcaataata tttctgcaat catgacatcg gtaatgtgac
     4501 gttataatga tttaatgcag cttttagtac tttaaagaag ttctcaatat catctacttc
     4561 tatctctcct aaagcacaga ttctaaaagt atcctcagtt gatatcttac ctggataaat
     4621 cgtaaatcca cgctcataac aataatcatg tattttctca aaatcccagt tgggatcttc
     4681 tgggtattga actgagacaa ccagtcctga ctgccattca cgctttatta cacttttaag
     4741 accaatttca tttatacctg aatgaatagc ctcaaaaact cttttgtgac gggcaaactt
     4801 agcttcttca cccacttcaa aatattcatt taatgcctga cgagtggcgt aaatagtttg
     4861 taccggtgga gtaaaatgca tttcacctgt tctctcaaaa ttctcatact gcaaataaag
     4921 attacaatag taagaacgct tgggatattt ttttgaaaac ttaatctgtt cctcattgcc
     4981 tataataaaa gaaagacctg tcatcgcttg aagtcctttt gagcagatgc catacaaaaa
     5041 tccacattat ctttctctat atcaaaagga atcatgccca aagaagaagt agtatcgacg
     5101 acaaatttag cctgatattt atgagctata gcgcccatct cgcgaatagg gttcagaatt
     5161 cctgtacccg tctcgtgatg agtagtataa accatagcta tatcaggatt ttcttgcaac
     5221 acattttcca ccaccgataa atcaggacgt tcgtaaacgg aaaattccaa attaatatga
     5281 ggcaaaccat aatattgaca cacttctaca gcacgggtac tatatgcccc attattcact
     5341 ataagcaccc ttttgtcttc aggaagaaga gaatttagac atatatcaat attgatggtt
     5401 cctgagccac aaaataatac agcggtatgt ttttccaaat tcccatgagc aactctgacc
     5461 aaatcgtccc gaagttgttt catcatacct gcgaattctt tctcgcgagg acaaatatcc
     5521 ggaacaactt gtgccatttt tacactgtca gtagtagtgg caggcccagg atttaataat
     5581 atttttcttt ctattttcat cgaatatatt tattttaaaa aatccataaa atgctcctta
     5641 ttctctatag gagtagtcgt gggacgtccc aaattctccc gagaatctat tttaaccttt
     5701 atttccaaca aaacaggacc acataacttt ggaagctgct tcattgcttc ttcaatttca
     5761 acttttgtac aaacagtata agtatgctta tatccgctcc cccggacaat agccggaata
     5821 tctaaactaa atcctaaagt aggctgtcct cctacagact cgtgagcacc attgttaaac
     5881 aaaatatgat aatagttttt aggagataaa tcgccaatgt tactaattgc ccctaaatgc
     5941 ataataaatg ctccatcacc atccaagcaa taaacaggtc tatcttgctt tgctatagca
     6001 atacccaaag agattgatga actatgtccc atagagccta ccgtgagaaa atcatgttca
     6061 tgaccttgct ctttcatttc tcgatattca aataactcac gagaaagctt gccagtagta
     6121 gaaacgacca ctgaattttc aggcagataa tccacaacta tttgcaaagc atcctcacga
     6181 gataaaggat aattacatcc gaactctttt tgaagtttat atttgccaaa aacatctttc
     6241 cgaataatta ttgcatgagg aatattctta gtttttgctg attgtatgat atcatggagc
     6301 tgaataaatg catcattctc atttgaatca agaattatat aaggaatccg cattgctttc
     6361 aacaaatcta aagttacctc accctgtttt ttatgctgag gttcatcttt tgttcccggt
     6421 tcaccacgcc agccaatcat caaaagcatt ggaaaactgt atacttgttc atctgcaaga
     6481 gacagcagag gattaacagt attacccaag ccggaatttt gcatataaac cacaggaacc
     6541 ttacctgatg ccatataata acctgaagca attcctacag ccgcaccttc attagcagct
     6601 atgatatgtt tctcacgtga agtatggtct gtgatatagg cacaaatatt ttttagtaat
     6661 gagtctggaa ctcctgtaaa aaaatcaacg tcatgactca gaaacgtttc ataaactttt
     6721 tctacgctta acataatgat attcctcttt ttatttagta cctggaatca gttccaatat
     6781 ttcttttatg ggcatacaca gttcgcgcac ctctaaagca cgttcattct ctaatattat
     6841 ctttgcgaca ttcatcatag caggataagc ggcacgaagc atatgattag cataaataat
     6901 tatattcaca ccccaatcac acaattcaga ctcataaata tgatcatatg tagtaggcac
     6961 aaccacgata ggtacatgag catactgttt tcgaaacgcc aaacaaaatt cttttatatc
     7021 ttcacccgac ttatttttgc tatgtatcat aataccgtcc gctcccgctt ggacatatgc
     7081 aaaagctctc tctaaagcat cacttaccgg ctttcccgct ataaggctct caatacgagc
     7141 gataatcata aaatcatcag taatctgaga tgcctttcct gctttgatct tattacagaa
     7201 accttcgatt gtatcttgag tttgaataac atctgtacca aacaatgaat tcttttttaa
     7261 tccaacttta tcttcaatta ttatagctga aattccatga cgttctaaag tgcgtactgt
     7321 aaatacgaaa tgttcaattt taccacctgt atctccatca aaaataatag gtttagtagt
     7381 acactccaga atattattca aatcttgcaa tcgggtagtt aaatcaaccg cctcaatatc
     7441 aggtttacct ttactggttg aatccgtaag gctactagac cacattccgt caaatacttc
     7501 cctcttatcc ccttttaata tttcctgatt ttcaattatc aagccacata gtccatcatg
     7561 agcttccaaa atacgaacta cgggtttggc atttatcaaa cgacgaagtg attttaaacg
     7621 tacatcaggg gttgtaccta tagccttaat atctttatcc aaagaagatg aattaattcc
     7681 caaagtatat ggaatttcga taacctttcc tccctgttca ttcatcactt caaatacgcg
     7741 cacacgttct tcacgtaaag gcccggtttt ccagtcgtca ccatgaatta tatagtcagg
     7801 tttaatgcgt ttgagattct caacatagct ccattcttct tgaggaacaa ctttacatac
     7861 gcctttaata ttctgaacta cctcttttcg ttgttcatag gtcagataag gaaggcgttt
     7921 atgctccgca atagctttat ctgtaagaag accaattata acatcaccgt atttagtagc
     7981 ctcattaata atgcggataa gtcctggatg cataatatcc gcagtcatcc caatataaac
     8041 tgtcttactc ataatttgat atattatttt aattaacaat acggaacaat atatttctct
     8101 gcatattcca aatctgatat gtcatcgatt tcataccatt tcagcccttc tactttatgc
     8161 acataaacag gagattgaga acaagatatt cgtagtaatt catactcata tcccaaattg
     8221 ggttgttcat caacaatact cgcataatca gcacacatta ttttgtaaaa ggaaccggat
     8281 agtttatgga tgccgaccaa ttcgccttta gcgtttagtt tattcttatt gacagaacat
     8341 gaagaaaggc gaaaattatc atcatgttcc acataatact gatcttgaaa ctttgtcact
     8401 ggagttatta gcattgcatc tgccgcagga cactccaata agctcattat tgcttgtttc
     8461 tcaaaaatca aatctgactc taacaataaa aaatcatcat tgcccagaat ctcccgcgta
     8521 ttatataaag tatacatact atttgtttca gcataacgag gactaaaaca ggtttcaagc
     8581 ataggatagt ctgtcttcaa ttcttcataa acttcttgtt tatatcctgt accgattaca
     8641 attcgctcaa tgtcacatga taacaaagta tcaatagaac gaactatcat tggaatacct
     8701 cccactttga cgaacccttt aggtatcaat tctgtatatt ggccaaaacg ggttcccatg
     8761 cccgcagcca ttatcatagc tgtacgtatc attcgtttaa taatatagta agtgaattta
     8821 attgatgtaa gaatgttgta aacgacgttt tagcatcatt tatcctgttc tatctcctta
     8881 tttttcagtt cttttctcaa gctagccagc agacttttgc caaaaaacac ccacacgaga
     8941 gtaccagata cggacaggaa cacaaataat aaaatataaa ttttgagtcc catacctgaa
     9001 ggtttcaaag gtacaacggc aggctcaact actgcaaaga ctggcttttc ctcctgtact
     9061 ttggctctgg atacctgcaa ctgattagca acctgactat atatctgata agccaaactc
     9121 atgtcgttct gtaaacgctc ctgctcagca cgtacacttt gaagaaccac attatcatgg
     9181 gcgtctacat aatccgcata ttttctttga gcagcataat attcctgctg acgttcttta
     9241 aacaaccgtt ccaaatacgc acagtcttct tttacttttg aagttcgata cccaataata
     9301 tattcctgta atttatgaac gacagaatct gctataaccg cagtgatctg cggattttgt
     9361 aaggtgaccg taatgctcgt tatggcggtt ttcttatcaa tggatgcact aatcttcttt
     9421 ttaagaaaat taatcttctc atttacttct ttcgtcaatt cgatagttcc ttgccgccct
     9481 ccactggcag gaaccgtatc ttctccgaat aatgatttaa ctcctcctat tactatgccc
     9541 ggaaaaccta taagataatc ccaccaagga gatgactctt catcgagata agaccccaaa
     9601 gtcattttat catccttttt agaaacggag acttccattt ctaaaagttc caataaaaaa
     9661 ggagttgaag aaacaatatc tgctgaaaga gaagcgttca aggcatctgt gctttcccct
     9721 attagagccc catctcccaa aaacgaggca gcaagtccgg ctaaaccatt acttcccttc
     9781 gcattaccca tttcaggaga aagggtaacc tttactgtat attgcttggg aatgctcaat
     9841 gccaccacta tagcaattat tactcccact ccagcagctt tgcatagtac tccacgaaca
     9901 gtaataatct tataaaaaat agccatcaag tctatttcca tttcatcatc tttcctttta
     9961 tccacttcag aaaacggttc ttgataagat tgcttttcaa tcataatagg tcatttattt
    10021 ctttatcaaa ttagcaatag aagcaatcat cattcccaaa gaactgaagg aagtagcata
    10081 acctaaaata ttagctatgt tccctttctt cttagcctta ccaggcacaa taatctcaca
    10141 ccccggctca atctgtttct taccactacc cttaaccttc gtcacctgac cattcatgta
    10201 aacaatgaac ttcttactct tccttgcatt atcagaacag ccaccggcct gattcaggta
    10261 ataatccaca ttctttccct tcatataaga aaccgtattc ggaaccatga cagcaccatt
    10321 gatagttaca gtattagtat tcttaggtat ggagatcaca tcaccttcac gtaagacaag
    10381 atcggcatta cttttaggat tgctcaaggc tttttccaaa tctattccaa ccgtaaaagt
    10441 atcttcaaca cgaataccca aagagtcaat catggcttcg cccaattgcc tgctcataag
    10501 gcgaattaca tcacccatac gtttcttttc actagcgtta gccacacggg tcagtttcgc
    10561 accacgcaga taggcataat tggtcggacc accggcttta ttcactaaat cggaaagacg
    10621 ttcctcacgg ctggtcatgg cgtaatttcc tccgaaaagg atttcacctt caatggctac
    10681 attctgttgt gcctgatagc ccggactgcg acggacataa acctgatcat aaggctcaag
    10741 gataaaaccg ggctgaccat ctattacaaa accatccttt aaagagaagg tatacatctg
    10801 accaatcgta tcattatccg cagtactacg aggattcttg attcgtctcg atatatcaat
    10861 acggacagta gaggcggctt ctttcaagcc accggcctga atgatcagat cctcaagtgt
    10921 catgttatcc gcataaggat aggaatcagg gtgggcaacc tcaccgtgaa ctgtgacatt
    10981 accccggtct tccaggtcat ggatacttgg aatgtagagg atgtcattct tcattagggc
    11041 aaggtttggg gaagtgccgt ccatgataga cttaatgtct atctgaacaa cttcactggt
    11101 caggtcttca cgctggcgat agaggacggc acgattcagg aaagcgtcac cggtcagacc
    11161 ctgagcttca tggacaagtt cgcggatcgt gttcagttta ccgctgagct ggtagatacc
    11221 gggacgatag acagcgccac ggatttccag tttgtttgtg aagcggttaa ggatggcttc
    11281 ggcggttact acgtcaccgt tacgcatttt ataaatgttg taatctatat ctttgactgt
    11341 gttgacttcg tattcctcac cattctgacg gacaacacgt aatgaacggg tgtaggcatc
    11401 ggcttcaaag ccgccggcat atttgattaa agtggcaagg ttctcttctt tcttcatttc
    11461 aaaacgcata ggacgtttta ccttgccgct gatctttacc aatacatcat aagcgggaac
    11521 aatcacgacg tcaccttcct gaaggcggat gtcatcctgt gtgttgcctt tcatgataaa
    11581 ttcgtagacg tcgatggtgg caatattctt tccgttgcgt accaactgaa cgtttcggag
    11641 gctaccgata tcactcacac cgcctgcacg ataaagcgca tggaagacgg tagagaagga
    11701 agaaagggcg taggtaccgg gctgtacgac ttctcccatc acattaatct gaatagtacg
    11761 gatattacct aacgtcagac ggatgtcgga agttggatcg gtcgtgttgt tcagaccgtt
    11821 atatatttta ttcagggcgt tcttcagata gtcattggcg gcagagactg tcataccgct
    11881 aaggttgaca gggccgatct tctgaatgtt gatagtacct tcaggagaga tttgctggcg
    11941 gatcgtgttc tggctcgcac cccagatatc aatgatgact tcatcaccgg gaccaagacg
    12001 gtaattggca ggagtggcaa ggttgacact aggctcgaac gtcaggttgc gggtattgaa
    12061 gatgttacgt ccgaagacct gatcaccacg ggcaaggtcc tgagtagtcg gatgatcctc
    12121 cagcatatcg gaagtattct tcttagtctc ttcacgcagg cgggattcgt tgatgtccgt
    12181 gcccgttgat ttcgaggtat ttacattgtt ctgctgctcg tatagctgct tcacacgcat
    12241 tgcctgttct ttggttacac ccttacgggc tagttcggaa gcaagctgct tctgttcctt
    12301 gccttggcgg atgccgtctt ttacatattc cagtacctgt gagtcactca tggactgagc
    12361 cataagcgag ccacttccca gcatcaaaca gaagagtaga atgctaaaaa gtcgttgtat
    12421 tttcattgac aaataaaaaa gtttcagttg atttcacaca gttcctgcat cccatgacag
    12481 acggcagata actgttgctt aagaagagaa gggggaagaa catcgagaag agacagagaa
    12541 cgggtcaaaa cagcctgttt tctttcttcg tcttccggat tggcgtacat cgacacatta
    12601 tatccctgaa ggatggccaa acacagggta gcatcctgct ccggtgtctc ccccgttgag
    12661 aatataaatc gttaatcttt tcgtggatgg atcgttgtaa tgctgaaaga tcatccaaat
    12721 acacgcagcc tgcactcccc ccaccaggaa gcagcatacg taccaaactt aataaaccct
    12781 ctatattttc ttgtaaaata atagcatcca tatcccttgc cttaaacagc cgccataatc
    12841 ggctctacat aaccgacagg catatcaaca caggcgcatc ccagcatatt caagcgaaca
    12901 gcaatcttac ttttaccatc cacattgacc agttcgccaa caagacccgt caacggacct
    12961 ttgatcacgc gaaccttttc gccacgagcc aaaggagaac tgttcatgct tatcgattct
    13021 tccgaataat caagcatgaa acggaaacga gccatctgct cgtcaggaat tacagcagga
    13081 ctactctcgc cgcgcatcac catgtaacgg ctgacagtag aaaaactcag gacttccatg
    13141 cgttccttag ggtcaacgtg tacgaagacc atcataggaa gcaagacgga ggtgaccagc
    13201 ttgcgacggt cgctccattg gtggaattcc tgttgaacgg gaacgaaatt ctcgataccc
    13261 atcttgtcca gatgctcgga aaccttcttt tcatggtgca tccgaaccaa agcaacatac
    13321 cagcgttttg agtgtgctac gccttcccct gtcccattaa taggcccagc atttagtgat
    13381 ttcttttttc ttaaaatcat atttttttac cccatgttta tccgttactt cttaggtaac
    13441 gaacaagcat agggcaagca gaaaagggaa cttttttcaa cgaaaacatc agaagaggac
    13501 tggtattcag gaaataaagc agaagtgaag gtgtttttca tgaattggaa taaaaaaaga
    13561 cataacacgg atattgtcat tttccgcctg ttatgcctgc atttgattca ttttccgaaa
    13621 ttaatttcat ttttgtttgc gtattttcat aaatatgtcc atctttgcgc catgaatcat
    13681 tccgttacct aagaagtaac gcacaccgat aaacactgta tatcaagctt ctaaatcaga
    13741 tacactgacc tactccgcac cgctttacgt aagacaaatt catccggttc ac
//
