LOCUS       gnlProkkaKLGOFCGL_6    14315 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KLGOFCGL_6.
ACCESSION   gnlProkkaKLGOFCGL_6
VERSION     gnlProkkaKLGOFCGL_6
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:13:41
            Original ID  :: gnl|Prokka|KLGOFCGL_6
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1061590
            Orig. end    :: 1075905
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14315
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9315]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9315
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14315
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14315
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             492..971
                     /locus_tag="ctg6_946"
                     /transl_table=11
                     /translation="MHHEKKVSEHLDKMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMV
                     FVHVDPKERMEVLSFSTVSRYMVMRGESSPAVIPDEQMARFRFMLDYSEESISMNSSPL
                     ARGEKVRVIKGPLTGLVGELVNVDGKSKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             1367..3778
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_947"
                     /sec_met_domain="Poly_export (E-value: 3.5e-16, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3789..4937
                     /locus_tag="ctg6_948"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_949"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.3e-14, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_950"
                     /sec_met_domain="CTP_transf_like (E-value: 6.4e-11,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.7e-119, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7.5e-61, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8246
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 57.9;
                     E-value: 1.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_951"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4e-18, bitscore:
                     63.6, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.4e-18, bitscore:
                     63.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFFKINIFDENRKKNIIKSWACHYY"
     CDS             8194..9315
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg6_952_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_952"
                     /sec_met_domain="Aminotran_5 (E-value: 5e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8284..9291
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg6_952_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg6_952_Aminotran_5.1"
                     /locus_tag="ctg6_952"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9312..9455
                     /locus_tag="ctg6_953"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9658..10377
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_954"
                     /sec_met_domain="Polysacc_synt (E-value: 1e-21, bitscore:
                     75.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKSFLL"
     CDS             10554..10796
                     /locus_tag="ctg6_955"
                     /transl_table=11
                     /translation="MVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLN
                     LLWVKGRSDLSLRLEIIKRRLLYSFFLCQFHLGLR"
     CDS             10796..11140
                     /locus_tag="ctg6_956"
                     /transl_table=11
                     /translation="MCWGRVIYSLIATYLNTYYTNSLIDLTLKLQVKDVFPSLILSFIM
                     GGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFCILTLIIKTKNIDENIK
                     KDFSSNSKDN"
     CDS             11094..11645
                     /locus_tag="ctg6_957"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFVFVEQVNVLQLLFIMIFHLKNALNRLFVWGIILHSKMIIIWEIIL
                     MINFVIQHVTHLITLLLLLV"
     CDS             12359..13027
                     /locus_tag="ctg6_958"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKEWKYR
                     "
     CDS             13107..14147
                     /locus_tag="ctg6_959"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 gtgaaccgga tgaatttgtc ttacgtaaag cggtgcggag taggtcagtg tatctgattt
       61 agaagcttga tatacagtgt ttatcggtgt gcgttacttc ttaggtaacg gaatgattca
      121 tggcgcaaag atggacatat ttatgaaaat acgcaaacaa aaatgaaatt aatttcggaa
      181 aatgaatcaa atgcaggcat aacaggcgga aaatgacaat atccgtgtta tgtctttttt
      241 ttattccaat tcatgaaaaa caccttcact tctgctttat ttcctgaata ccagtcctct
      301 tctgatgttt tcgttgaaaa aagttccctt ttctgcttgc cctatgcttg ttcgttacct
      361 aagaagtaac ggataaacat ggggtaaaaa aatatgattt taagaaaaag aaatcactaa
      421 atgctgggcc tattaatggg acaggggaag gcgtagcaca ctcaaaacgc tggtatgttg
      481 ctttggttcg gatgcaccat gaaaagaagg tttccgagca tctggacaag atgggtatcg
      541 agaatttcgt tcccgttcaa caggaattcc accaatggag cgaccgtcgc aagctggtca
      601 cctccgtctt gcttcctatg atggtcttcg tacacgttga ccctaaggaa cgcatggaag
      661 tcctgagttt ttctactgtc agccgttaca tggtgatgcg cggcgagagt agtcctgctg
      721 taattcctga cgagcagatg gctcgtttcc gtttcatgct tgattattcg gaagaatcga
      781 taagcatgaa cagttctcct ttggctcgtg gcgaaaaggt tcgcgtgatc aaaggtccgt
      841 tgacgggtct tgttggcgaa ctggtcaatg tggatggtaa aagtaagatt gctgttcgct
      901 tgaatatgct gggatgcgcc tgtgttgata tgcctgtcgg ttatgtagag ccgattatgg
      961 cggctgttta aggcaaggga tatggatgct attattttac aagaaaatat agagggttta
     1021 ttaagtttgg tacgtatgct gcttcctagt ggggggagtg caggctgcgt gtatttggat
     1081 gatctttcag cattacaacg atccatccac gaaaagatta acgatttata ttctcaacgg
     1141 gggagacacc ggagcaggat gctaccctgt gtttggccat ccttcaggga tataatgtgt
     1201 cgatgtacgc caatccggaa gacgaagaaa gaaaacaggc tgttttgacc cgttctctgt
     1261 ctcttctcga tgttcttccc ccttctcttc ttaagcaaca gttatctgcc gtctgtcatg
     1321 ggatgcagga actgtgtgaa atcaactgaa acttttttat ttgtcaatga aaatacaacg
     1381 actttttagc attctactat tttgtttgat gctgggaagt ggctcgctta tggctcagtc
     1441 catgagtgac tcacaggtac tggaatatgt aaaagacggc atccgccaag gcaaggaaca
     1501 gaagcagctt gcttccgaac tagcccgtaa gggtgtaacc aaagaacagg caatgcgtgt
     1561 gaagcagcta tacgagcagc agaacaatgt aaatacctcg aaatcaacgg gcacggacat
     1621 caacgaatcc cgcctgcgtg aagagactaa gaagaatact tccgatatgc tggaggatca
     1681 tccgactact caggaccttg cccgtggtga tcaggtcttc ggacgtaaca tcttcaatac
     1741 ccgcaacctg acgttcgagc ctagtgtcaa ccttgccact cctgccaatt accgtcttgg
     1801 tcccggtgat gaagtcatca ttgatatctg gggtgcgagc cagaacacga tccgccagca
     1861 aatctctcct gaaggtacta tcaacattca gaagatcggc cctgtcaacc ttagcggtat
     1921 gacagtctct gccgccaatg actatctgaa gaacgccctg aataaaatat ataacggtct
     1981 gaataatact accgatccta cttccgacat ccgtctgacg ttaggtaata tccgtactat
     2041 tcagattaat gtgatgggag aagtcgtaca gcccggtacc tacgcccttt cttccttctc
     2101 taccgtcttc catgcgcttt atcgtgcagg cggtgtgagt gatatcggta gcctccgaaa
     2161 cgttcagttg gtacgcaacg gaaagaatat tgccaccatc gacgtctacg aattcattat
     2221 gaaaggcaac acacaggatg acatccgcct acaggaaggt gacgttgtga ttgttcctgc
     2281 ctatgatgta ttggtaaaga ttagcggcaa ggtaaaacgt cctatgcgtt ttgaaatgaa
     2341 gaaagacgag aaccttgcta ctctcattaa atatgccggc ggctttgaag ctgatgccta
     2401 cacccgttca ttacgtgttg tccgtcagaa tggtgaggaa tacgaagtca acacagtcaa
     2461 agatatagat tacaacattt ataaaatgcg taacggtgac gtagtaaccg ccgaagccat
     2521 ccttaaccgc ttcacaaaca aactggaaat ccgtggcgct gtctatcgtc ccggtatcta
     2581 ccagctcagc ggtaaactga acacgatccg cgaacttgtc catgaagctc agggtctgac
     2641 cggtgacgct ttcctgaatc gtgccgtcct ctatcgccag cgtgaagacc tgaccagtga
     2701 agttgttcag atagacatta agtctatcat ggacggcact tccccaaacc ttgccctaat
     2761 gaagaatgac atcctctaca ttccaagtat ccatgacctg gaagaccggg gtaatgtcac
     2821 agttcacggt gaggttgccc accctgattc ctatccttat gcggataaca tgacacttga
     2881 ggatctgatc attcaggccg gtggcttgaa agaagccgcc tctactgtcc gtattgatat
     2941 atcgagacga atcaagaatc ctcgtagtac tgcggataat gatacgattg gtcagatgta
     3001 taccttctct ttaaaggatg gttttgtaat agatggtcag cccggtttta tccttgagcc
     3061 ttatgatcag gtttatgtcc gtcgcagtcc gggctatcag gcacaacaga atgtagccat
     3121 tgaaggtgaa atccttttcg gaggaaatta cgccatgacc agccgtgagg aacgtctttc
     3181 cgatttagtg aataaagccg gcggtccgac caattatgcc tatctgcgtg gtgcgaaact
     3241 gacccgtgtg gctaacgcta gtgaaaagaa acgtatgggt gatgtaattc gccttatgag
     3301 caggcaattg ggcgaagcca tgattgactc tttgggtatt cgtgttgaag atacttttac
     3361 ggttggaata gatttggaaa aagccttgag caatcctaaa agtaatgccg atcttgtctt
     3421 acgtgaaggt gatgtgatct ccatacctaa gaatactaat actgtaacta tcaatggtgc
     3481 tgtcatggtt ccgaatacgg tttcttatat gaagggaaag aatgtggatt attacctgaa
     3541 tcaggccggt ggctgttctg ataatgcaag gaagagtaag aagttcattg tttacatgaa
     3601 tggtcaggtg acgaaggtta agggtagtgg taagaaacag attgagccgg ggtgtgagat
     3661 tattgtgcct ggtaaggcta agaagaaagg gaacatagct aatattttag gttatgctac
     3721 ttccttcagt tctttgggaa tgatgattgc ttctattgct aatttgataa agaaataaat
     3781 gacctattat gattgaaaag caatcttatc aagaaccgtt ttctgaagtg gataaaagga
     3841 aagatgatga aatggaaata gacttgatgg ctatttttta taagattatt actgttcgtg
     3901 gagtactatg caaagctgct ggagtgggag taataattgc tatagtggtg gcattgagca
     3961 ttcccaagca atatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggaa
     4021 gtaatggttt agccggactt gctgcctcgt ttttgggaga tggggctcta ataggggaaa
     4081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     4141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgttttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttacatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtga cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaataact ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccctgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tttcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacag atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agataatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaaag aaatattgga
     7021 actgattcca ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     8041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     8101 aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     8161 attttatgga tttttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta
     8221 aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt
     8281 tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga
     8341 gttgctcatg ggaatttgga aaaacatacc gctgtattat tttgtggctc aggaaccatc
     8401 aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat
     8461 aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt
     8521 aatttggaat tttccgttta cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa
     8581 gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac aggaattctg
     8641 aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat
     8701 actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt ggatttttgt
     8761 atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat
     8821 gaggaacaga ttaagttttc aaaaaaatat cccaagcgtt cttactattg taatctttat
     8881 ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact
     8941 atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggtgaaga agctaagttt
     9001 gcccgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa
     9061 agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat
     9121 cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat
     9181 ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta
     9241 gatgatattg agaacttctt taaagtacta aaagctgcat taaatcatta taacgtcaca
     9301 ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc
     9361 gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct
     9421 tagtaggcaa atatggcaat attaatttga ggtgatgcat taggagttct ttattcttat
     9481 aaaaaggcat cggtagttat aggagataat gtttgtgtag ggtaatttgc ttttagtggg
     9541 agagaccata ttagaattgc ggtaaggggc gaagaagata ataaccaatt agtgagaata
     9601 ttggaaaaat ataattgata tcggtaaatg tagttgtttt tatactgtat ttaagtaatg
     9661 gaaaatctaa agcagaaaac tgtatcagga ataatgtgga gcgctataga acgtttctct
     9721 ttacaaggag tacagtttat aattcaaata atattagctc gtttgttact accatcggat
     9781 tatggtatga tcgggatgtt agctattttt cttcaagtcg ctcaagtatt tatagatagc
     9841 ggttttacaa atgctttaat ccagaaaaaa gatagaactg aagaggattt tgccactgtc
     9901 ttttatttta atattcttgt cgcagtatta ttctatggta tattgttttt ttcggcttct
     9961 ttgattgcag acttttataa tatgccgact ttagttcttg taattcgttt tatagcattg
    10021 tcgttgataa taaatgcttt atcggctatt cacagaacga aattaattat ttctgtaaac
    10081 tttaaaactc aatctaaaat ttcattaggt gcagctttta tatcaggcgt gattggaata
    10141 tggatggctt atgtcggttg cggggtttgg gctttagttt ggcaaactct cttaaatagt
    10201 ataattttga caattttgtt ttactgttta gttcattgga aacctttaca tactttctcc
    10261 aaaagttctt ttgaaagatt attcaatttc ggatctaaat tattgatctc aagtcttatc
    10321 aatacagtat atcgtaatct gtataccatt gtaataggaa aaagttttct gttgtagagc
    10381 ttggttacta tacaagagca gaacaatttg ctatttttcc ttccaataat ttaaatgctt
    10441 tagtttctag agtagcgtat cctattttaa gttccattca agatgatgat aaatgtttaa
    10501 caaacgcata tcgaaattat atcagattat cctcatatat aatttttcct ttaatggtag
    10561 gtttacttgt tttggctaat cctattatta gtctattgtt aacagataaa tggtctgggg
    10621 ttgttattct tttacagata ttatgtttgg attggatgtt tgatcatttg agccaaatta
    10681 atttgaattt attatgggtt aaaggaagat ctgatctgtc gttacgtctt gaaataataa
    10741 aaagacgatt gctatattca ttctttttgt gtcaattcca tttgggcttg aggtgatgtg
    10801 ttggggtaga gttatttact ctctgatagc gacatatttg aatacatatt atactaattc
    10861 tcttattgat ttgaccttaa agttgcaagt taaagatgta tttccaagtt taatactctc
    10921 tttcataatg ggggggatcg tttttatatg tatttctttc tttgaaactg atatagtaaa
    10981 aattgtgatt ggatgtatta ctgggatgtc cttctatatt ttactttctt ttctttttaa
    11041 gctagattct tttttttgta ttttaacatt gatcattaaa actaaaaaca tagatgaaaa
    11101 tattaaaaaa gatttttcaa gtaatagtaa agataattaa ccattgtgtg ccagttgata
    11161 gtagatcatt gtattttatt cctcatccta attgtagaac agataaatat gatattataa
    11221 attattcgtc agataatgtt ctcgttctgt taaattattt gctaaaaaaa gatagtgctg
    11281 aatattataa aatatatgtt gaaatttatg attcttctcg tatttcagaa tatcaagaat
    11341 atatttatgg cataaatcct aatattaggt gtactttttt atgtgcatgt gttggacgtt
    11401 ttttctttaa taaagtatct tttaaggata tgttgtatgc cttttttgtt tttgtagagc
    11461 aagtaaatgt tttacagcta ctttttatta tgatttttca tttaaaaaac gctctcaaca
    11521 gattatttgt ttggggtatt atactccatt caaagatgat tatcatatgg gagatcattc
    11581 ttatgataaa tttcgtaata caacatgtaa ctcatttgat tactctattg ctacttcttg
    11641 tttaagtgct agaataattt caatagattg tggaatctca tatgataaat tcaaagtctt
    11701 aggatttccc agaaatgatt tgttgatatc gaaaaataat tgcaatgtta ttaaaagaga
    11761 aatttcgaaa tttgcgggat atgatgtaac taaatatata gtttatactc caacttttcg
    11821 tgattatgag actgttactg aaggtaattt gcgttcaata ctcggatatg ttgattgtga
    11881 tttgttgaag ttatcgaaaa tactattgaa gtttaatgcg gctttaattc ttaaattaca
    11941 tcctttgcag aataaaacag tcttaaaaaa gatttaccca aaggtatact tgtttttgaa
    12001 caaacatata aatatggatt gtatgatctt ttgtcatttt cagatggaat gattactgat
    12061 tatacttcta cctattttga ttttttattg gtaaataagc cagtcatatt taatttctac
    12121 gatattgaag aatatcgtag agtaagaggt ttctcatttg agccaataga attttttgtg
    12181 caggtgatat tgtttacaat tataatgaat tgatagatgc tgtgatggga cttctggctg
    12241 ggaaagatat tcatgctgaa catcgacgtc atatttcttt attgatgaat caatttcaag
    12301 atgataattc aacaaagaga atatgtgaca tatttttaaa tgaaatataa taaataaaat
    12361 gaattatgca tttgtggtgc aggcacgttt aggttctaca cgtttgcctg gaaaaatatt
    12421 gaaacctttc tatggtaatc aatcgattct tgacttaatg gttcataagc tttctgctat
    12481 atcgaatatt ccagtaatta ttgctacaac aaattctgtt atcaatgaac ctattgaaaa
    12541 gaaggcactt gcattagggg taaagtgctt cagaggtgag gagaatgatg ttttaaaacg
    12601 attcattgat gttgctgaat attttgatat acagggtata ttccgaatat gttctgataa
    12661 tccattttta gatgtacatg cggcaaggca attggtcgaa atagcaatga aatcttgtaa
    12721 cgattatata agttttgata ttgatggtac tccatcaatt aaaactcatt tcggtttttg
    12781 gggagaattt gtaacgcttg atgcgctgaa gcgagttata ggatttactg atgatttatt
    12841 gtatcgtgaa catgttacta attatatata tagtcatcct gaacttttta atattcaatg
    12901 gatttcagga tctccagtcg tgtcaaaaca tcataatatt cgactcacga ttgatacgtt
    12961 agaagatttt tctgtagcac agagaatata tagggattta caagaaaaag agtggaaata
    13021 tcgatagaag tgattgtaga ctatgttcga agacatgcag aatacattca actgatgaaa
    13081 caacaaataa aaaaaaattc taaataatga agaatactta tattattggt gaaatagggc
    13141 agaatcataa tggttctgtt gacttggcta agttgattat tgaattaatc tcacgacctg
    13201 tacatgagga tgtttttggt atggatttca tgccaatgaa tgctgttaaa atgactaaaa
    13261 gagatttatc agaagaattg gctgtttctc aaatgaatca aatatatgac aatcctaatt
    13321 cttttgggcg tacttatggt gaacatcgtg cttttcttga gcttgatgat caagcgcatt
    13381 ttgagattta taaatatgct aagtcattag gattagattt tatcgagacg ttatgtgcca
    13441 aaggatgtct gtctttgctt aaactgttca caccggatag gctaaaagtt gctagtcgtg
    13501 atttgactaa cttaccattg cttgaagcat tagcagaaac tcatattcct attatattat
    13561 cgacaggaat ggctggtcaa agagaacttg acaatgcatt agatgtgata acgagatatc
    13621 atagtaatat agctattcta cattgtgtat ctcagtatcc aactcatcca aataatttga
    13681 atctacgtac aataacatat ttgaagaagc attacaataa gtttgagata ggtttttctg
    13741 atcatacaat aggtatttct gctgctacag ctgctgtagc gatgggagcg gaaattatag
    13801 aaaagcatgt aacaattgat cggcatatga aaggaacaga ccagcttggc tctttaggtc
    13861 cagatggggt taatcgtatg attcgagata ttcgcatagc agagtgttgg cttggtactg
    13921 aagatcttta tatagaaaaa ggggtggaga agtctaagat aaaacttgaa cgttctattg
    13981 ccactcgaaa atatattcca gcaggtagta ttattcaaga gtcggacatt catttactga
    14041 gtcctggtga tggttataaa tggatagata aaaaaaatgt aattggtcat tttgctaaac
    14101 aagatatatc agcgaatgaa ataatatatc ctgattttat tgaatagata tattcctact
    14161 gcaacttgta ttacggtata gagtactgcc tgctataagc taagtagtga ttaataaata
    14221 agggtaaaat actaaaaaaa tgaaagagat aaagcttata cttacagata ttgatggcgt
    14281 ttggactgat ggcggaatgt tttatgatca aacag
//
