LOCUS       gnlProkkaKHIPAOPB_5    14314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KHIPAOPB_5.
ACCESSION   gnlProkkaKHIPAOPB_5
VERSION     gnlProkkaKHIPAOPB_5
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:52:51
            Original ID  :: gnl|Prokka|KHIPAOPB_5
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3326687
            Orig. end    :: 3341001
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14314
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14314
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             489..968
                     /locus_tag="ctg5_2674"
                     /transl_table=11
                     /translation="MHHEKKVSEHLDKMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMV
                     FVHVDPRERMEVLSFSTVSRYMVMRGESSPAVIPDEQMARFRFMLDYSEESISMNSAPL
                     ARGEKVRVIKGPLTGLVGELVNVDGKSKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             979..1347
                     /locus_tag="ctg5_2675"
                     /transl_table=11
                     /translation="MDAVILQENIEGLLNLVRMLLPGGGSAGCVYLDDLSALQRSIHKQ
                     INDLYSQRGKTPEQDATLCLAILQGYNVSMYANPEDEDRKRSVLQRSLTLLDVLPPSLL
                     KQQLSAVCHGMQELCETN"
     CDS             1363..3774
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 30.3;
                     E-value: 2.7e-09)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_2676"
                     /sec_met_domain="Poly_export (E-value: 1.2e-15, bitscore:
                     55.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSQSTGTDINESRLREETKENTSDMLED
                     HPTTEDLAREDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKGALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVNEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIRSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTSLAYLRGAKLTRVASAGEKK
                     RMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIP
                     KNTNTVTINGAVMVPNTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3789..4937
                     /locus_tag="ctg5_2677"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2678"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.7e-14, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2679"
                     /sec_met_domain="CTP_transf_like (E-value: 9.1e-11,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.8e-119, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4.8e-61, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8183
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2680"
                     /sec_met_domain="TPP_enzyme_N (E-value: 5e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.3e-18, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8193..9314
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg5_2681_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2681"
                     /sec_met_domain="Aminotran_5 (E-value: 7.1e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8283..9290
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg5_2681_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg5_2681_Aminotran_5.1"
                     /locus_tag="ctg5_2681"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9311..9784
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_2682"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             9781..10086
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_2683"
                     /sec_met_domain="Polysacc_synt (E-value: 2.2e-14, bitscore:
                     52.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFF"
     CDS             10248..11225
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_2684"
                     /sec_met_domain="Polysacc_synt (E-value: 5.3e-12, bitscore:
                     44.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSGIIGIWAAYLDFGVGALVGQTLVNGLLIVVLYAYFCRWKPLW
                     IFSLKSFRLLFAFGSKLVLANILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSY
                     NLSAIISRVTYPILSLVQNDNDRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLT
                     EKWIGVVVLLQILCLDWMFDHLSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIP
                     WGIVGMCWGRVMYSLIAVYLNTYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMIL
                     LLEGEIVQIVVGSVIALLLYGTLLYCFSRSLFDEIWAVILKIKR"
     CDS             11225..11947
                     /locus_tag="ctg5_2685"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             11961..12173
                     /locus_tag="ctg5_2686"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIGNKFNLSKIVYIMI"
     CDS             12896..13192
                     /locus_tag="ctg5_2687"
                     /transl_table=11
                     /translation="MANYATNIFHASTENKQDLNKIEAFLDDNFNGFVNRYGDTVDAEF
                     DSRWEYPEKAINELIALLAAKDKIYIRILTYELEDEYVSFRIFSQGKWNIKLS"
     CDS             13211..13387
                     /locus_tag="ctg5_2688"
                     /transl_table=11
                     /translation="MYEYEEDSDIIGLSCTLLNPYKGYMEGTIVGDYGNTIVVRLESGK
                     EISEYRDEVIIHD"
     CDS             13402..13734
                     /locus_tag="ctg5_2689"
                     /transl_table=11
                     /translation="MTQIATKFVKWDIPELATLQDSKVYKLRVHLNNGGKLNREEKNWI
                     TRNVWESIYFKRGIALSGYHFDFSDILKRYFVKQHGSIHEYYAIDKTALRSILYGRIED
                     IVEVSG"
     CDS             13747..14043
                     /locus_tag="ctg5_2690"
                     /transl_table=11
                     /translation="MGEYKFYQDRKVTSWERDYFSVKADSYEEAEAIVRSWNCEDVSNI
                     IDNRLCYEEWQALTDTSESMLPEENDGNPTIEIFNQDGESIMTNVPETPQSNQ"
     CDS             14048..14305
                     /locus_tag="ctg5_2691"
                     /transl_table=11
                     /translation="MNVTIEHVFCRYSDEAEEIYFRIMNTILFATDETELRASMERLKN
                     ETTLDDYFIFGYGAHHIWIKQRRPSDKNRIFKHRIMVAHF"
ORIGIN
        1 aaaccggatg aatttgtctt acgttaagag gtgcggttct ggcctgtatg tgtgatttag
       61 aatcctgata tacagtgttt attggtgtgt gttacttctt aggtaactca caaacaaagg
      121 acaagcgaaa cagggaactt ttttcaacga aaacatcgga agaggactgg tattcaggaa
      181 ataaggcaga agtgaaggtg tttttcataa attggaataa aaaaagacat aacacggata
      241 ttgtcatttt ccgtctgtta tgccgacttt tgattcattt taagaaatta atttcatttt
      301 tgtttgcgta ttttcataaa tatgtccatc tttgcgccat gaatcattcc gttacctaag
      361 aagtaacgga taaacatggg gtaaaaaaac atgattttaa gaaaaagaaa tcactcaatg
      421 ctgggcctat taatgggaca ggggaaggcg tagcacactc aaaacgctgg tatgttgctt
      481 tggttcggat gcaccatgaa aagaaggttt ccgagcatct ggacaagatg ggtatcgaga
      541 atttcgttcc cgttcaacag gaattccacc aatggagcga ccgtcgcaag ctggtcacct
      601 ccgtcttgct tcctatgatg gtcttcgtac acgttgaccc tagggaacgc atggaagtcc
      661 tgagtttttc tactgtgagc cgttacatgg tgatgcgcgg cgagagtagt cctgccgtaa
      721 ttcctgacga gcagatggcc cgtttccgtt tcatgcttga ttattctgaa gaatcgatca
      781 gcatgaacag tgcccctttg gcccgtggcg aaaaggtccg cgtgattaaa ggccccctga
      841 cgggtcttgt tggcgaactg gttaatgtgg atggcaagag taagatcgcc gttcgcctga
      901 atatgctggg atgtgcctgt gtggatatgc ctgtcggtta tgtagagcct attatggcgg
      961 ctgtttaagg tgagggatat ggatgctgtt attttacagg aaaacataga gggtttatta
     1021 aatttggtac gcatgctgct tcctggtggg gggagtgcag gctgcgtgta tctggatgac
     1081 ctttccgcct tacaacgatc catccacaaa cagataaacg atttatattc acaacggggg
     1141 aagacaccgg agcaggatgc taccctgtgt ttggccatcc ttcagggata taatgtgtcg
     1201 atgtacgcca atccggaaga cgaggataga aaacggtctg tcttgcagcg ttctctgacc
     1261 ctccttgatg ttcttccccc ttctcttctt aaacaacagt tgtctgcggt ctgtcacggt
     1321 atgcaggaac tgtgtgaaac caactaactt ttttatttgt caatgaaaat acaacgactt
     1381 tttagcattc tacttttttg ttctatgctg ggaagtggct cgcttatggc ccagtccatg
     1441 agtgactcac aggtactgga atatgtaaag gacggcatcc ggcaaggcaa ggaacagaaa
     1501 cagcttgctt ccgagcttgc gcgtaaaggt gtgaccaagg aacaggctat gcgtgtgaag
     1561 cagctctatg agcagcagaa caatgtaaac acctcccaat ccacgggtac ggatatcaac
     1621 gagtcccgcc ttcgtgaaga gactaaggag aatacttccg acatgctgga ggatcatccg
     1681 actacggaag atttggcccg tgaggatcag gttttcgggc gcaacatctt caatacccgc
     1741 aacctgacgt tcgagcctag tgtcaacctt gccactcctg ccaattaccg tctgggtccc
     1801 ggtgatgaag tcatcatcga tatctggggt gccagccaga acacgatccg ccagcagatc
     1861 tctcctgaag gcaccatcaa tattcagaag atcgggcctg tcaaccttag cggtatgaca
     1921 gtctccgccg ccaacgacta tctgaagggc gccctgaata agatctataa cggtctgaac
     1981 aatactaccg accctacttc cgacatccgt ctgactttgg gtaatatccg tactattcag
     2041 atcaacgtga tgggagaggt cgtgcagccg ggtacctacg ccctttcttc cttctctacc
     2101 gtcttccacg cgctttaccg tgcaggcggc gtgagtgata tcggcagcct ccgaaacgtt
     2161 cagttggtac gcaacggaaa gaatatcgcc accatcgatg tttacgaatt tatcatgaaa
     2221 ggcaacacac aggatgacat ccgccttcag gaaggtgacg tggttatcgt ccccgcctac
     2281 gatgtcttgg taaagatcag cggcaaggta aaacgtccta tgcgtttcga aatgaagaaa
     2341 gacgagaacc ttgccacttt aatcaaatat gccggcggct ttgaagctga cgcctacacc
     2401 cgttcattac gtgttgtccg tcagaatggt gaggaatatg aggtcaacac agtcaaggat
     2461 atggactaca gcatctacac aatgcgtaac ggcgacgttg taacagccga agccatcctt
     2521 aaccgcttca caaacaaact ggaaatccgt ggcgctgtct atcgtcccgg catctaccag
     2581 ctcagcggta aactgaacac gatccgcgaa cttgtcaatg aagcccaggg tctgaccggt
     2641 gacgctttcc tgaatcgtgc cgtcctttat cgccagcgtg aggacctgac cagtgaagtt
     2701 gttcagatag acatcaggtc tatcatggac ggtacttccc cgaacctcgc cctgatgaag
     2761 aatgacatcc tttacattcc gagcattcac gatctggaag atcgtggcaa tgtcacagtt
     2821 cacggtgaag tcgcgcaccc tgattcctat ccctacgctg ataacatgac acttgaggat
     2881 ctgatcatcc aggccggtgg cttgaaagaa gccgcctcta ctgtccgcat tgatgtgtcg
     2941 agacgaatca agaatccccg tagtaccgcg gataatgata ctatcggtca gatgtatacc
     3001 ttctctttaa aggatggttt tgtcatcgac ggtcagcccg gttttatcct tcagccttat
     3061 gacgaagttt atgtccgtcg cagtcccggt tatcaggcgc aacagaatgt agtcattgat
     3121 ggtgaaatat tgtttggagg aaattatgcc atgaccaacc gtgaggaacg tctttccgat
     3181 ctggtgaata aagcgggtgg tcctaccagt cttgcctatc tccgtggtgc gaaattgacc
     3241 cgtgtggcaa gtgcgggtga gaagaaacgt atgggtgatg tgattcgcct gatgagcagg
     3301 caattgggtg aagccatgat tgactctttg ggtattggtg ttgaggatac ctttacggta
     3361 ggcattgatc tggagaaggc tttgactaat cctaagggta gtgccgacct tgtcctacgt
     3421 gaaggtgatg tggtctttat acctaagaat actaatactg taactatcaa tggtgctgtt
     3481 atggtcccca atacggtttc ttatatgaag ggaaaggatg tggattatta cctgaatcag
     3541 gccggtggct attctgataa tgcaaggaag agtaagaagt tcattgttta catgaatggt
     3601 caggtgacga aggttaaggg tagtggtaag aaacagattg agccggggtg tgagattatt
     3661 gtgcctggta aggctaagaa gaaagggaac atagctaata ttttaggtta tgctacttcc
     3721 ttcagttctt tgggtatgat gattgcttct attgctaatc ttataaagaa ataatagaat
     3781 ttacttttat gtcagaacaa cgacaggata aaaacttgct ctctgaacca cacaagacag
     3841 aaagtgatga gatagaaatt gatttggtcg atatctttcg caagattatt gctattcgta
     3901 aaaaattata caaagccgtt ggaattggtt ttattattgg aataattgta gcggtaagta
     3961 tccctaaaca gtatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggga
     4021 gtaatggttt agccggactt gctgcctcgt ttttaggaga tggggctcta ataggggaaa
     4081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     4141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgctttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttatatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtgg cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaatagct ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccccgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tctcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacgg atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agacaatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaagg aaatattgga
     7021 actgattccg ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     8041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     8101 aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     8161 attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa
     8221 atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt
     8281 gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag
     8341 ttgctcatgg gaatttggaa aaacataccg ctgtattatt ttgtggctca ggaaccatca
     8401 atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata
     8461 atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta
     8521 atttggaatt ttccgtttac gaacgtcctg atttatcggt ggtggaaaat gtgttgcaag
     8581 aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga
     8641 accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata
     8701 ctacttcttc tttgggcatg attccttttg atatagagaa agataatgtg gatttttgta
     8761 tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg
     8821 aggaacagat taagttttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt
     8881 tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta
     8941 tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggcgaagaa gctaagtttg
     9001 cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa
     9061 gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc
     9121 ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc
     9181 caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag
     9241 atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat
     9301 taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg
     9361 tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt
     9421 agtaggcaaa tatagcaata tctacttagg taaaaatgct gaaatacgtt caggctgtta
     9481 tctgattgct cgtgataaaa tcattattgg agaaaactca acactcgcct atggaacgac
     9541 tatattgaca actgctgatc ctaatggacc gtataatgca ttagcagttc tttatcctta
     9601 taaaaaggca ccggtagtta taggagataa tgtttggatt ggggctaatg ttaccatcct
     9661 tcctggagta actattggtg attacgttgt agtagcagct ggagctgttg taacaaaaga
     9721 tgtaccttca ggagtattgg tagctggtgt accagctatt gtgaaaaaac gttttaataa
     9781 atgaaagaaa aaacttcttt aaagaacaaa gccatatgtg gaatcttttg gagtgcagtt
     9841 gaacgatttt tatcacaggg gatacagttt gtagttacag tcattatggc gcgttttcta
     9901 ttgccatctg attatggaat ggtaggaatg ttagcaatag ttcttcaatt atctcaaacg
     9961 ttaatggata gtggttttac taatgccctt attcgttata aggaacgtac tgaaattgat
    10021 tattcaacag ttttcttttt taatatatta gcatcattag ttatttattt tctaattttt
    10081 ttctagctcc ttatatatcg tggttttata aaataggtca attagttgag attactagaa
    10141 ttttatctat tgttattgtt ttaaattcct ttgcgattat tcctaaaact aaattaataa
    10201 tagctgtaga ttttaaaact caatcaaaag tctcatttat tgcagctttg gtttcaggta
    10261 ttattggcat ttgggctgca tatttagatt ttggagttgg ggctttagtt ggacaaactt
    10321 tagtaaacgg attgttgatt gtagttttgt atgcatattt ttgtagatgg aaaccattgt
    10381 ggatattttc attgaaatcg tttcgtttat tatttgcttt tgggtcaaaa ttagtattag
    10441 ctaatattct taatacttta tataaaaatc tgtatgctat agttatagga aagaagtttt
    10501 cgtcggttga tttaggattt tatactcgtg cggaacaatt tgctcagttt ccttcatata
    10561 atttgagtgc aataatttct agagtgacat accccatatt gagccttgtg caaaatgata
    10621 atgatagatt atctgcttta tataggaaat atgtccgttt atcttctgct tttatctttc
    10681 cattgatgat tttgttaatt gtcatagctc agccactggt attattgctt ttgacagaaa
    10741 aatggatagg agtagttgta ttgcttcaaa tattgtgttt agattggatg tttgatcatt
    10801 tgagtagtat aaatttgaat ttactatatg taaagggacg ttcagacttg gctttacgtt
    10861 tagaagttat aaaaaaagtg ttagcgacgg ggatccttct tctatctatt ccttggggga
    10921 ttgtaggtat gtgttggggg cgtgttatgt attcattgat tgctgtgtat ttgaatactt
    10981 attatacaga atcattgatt aaattaagtc ttattagaca gatgagagat atactaccaa
    11041 gctttttttt agcattaata atgggaggag gtacttggta tatgatttta ttgttagagg
    11101 gtgaaattgt tcaaattgta gtaggaagtg ttattgcttt attgctatat ggaacgttgt
    11161 tgtattgctt ttctcgatcc ttgtttgatg aaatatgggc ggttatatta aaaataaaaa
    11221 ggtaatggat aaactgagtt tgattattag taaaatacga cggaatcatt ggtatagaac
    11281 ctatatgcgt cctatatatt tatttgttta tggcaataga aaattgaaga atagaaatag
    11341 aatatttttg cagtattcac aagagctgct aactaacttt catcaagcaa tgaatgaagt
    11401 gggaattcct tattggttag aatttggaac tcttttaggt gctgttagag aacacagttt
    11461 tataagtcat gattttgatc ttgatgtggg cctttttaag gaagattatt cagatataat
    11521 aagagaggtc ttaaaaaaat atggtttcaa aagaataagg tgtataaccg cccttgattt
    11581 tattgatgct tatgaggaaa cttatcttta taaaggtgtg acaattgatc ttttcctttt
    11641 ttcaagagag aaaaattgtg atggggtcta ttgttatgat tttgttccag tatattcaga
    11701 tataaagaga actaaaaaag gtgataatgc aatccggaga attcattttc ctagaattga
    11761 tttgattgaa tattcattta ttggaattaa tacttttgtt cctgaaaatt atgaggaaca
    11821 tctttgtatg cattatggta aagactatat gattccaaat cctcattgga aagattcaga
    11881 tgcgcaacat actgatatct tttatggtag agagattaga attgaattgt ttgataaaag
    11941 taaataatag tagataatac atgttctatc tatttttttt actaattgtg ctatttttgt
    12001 tatatataca aagtaggaaa agacaatatt ctactgtagc gggaatttgt gttcctatta
    12061 ttataatttt tgttgtaatt tgtcgttata gagtggggta tgactattta acgtattata
    12121 cattaattgg aaataaattc aatctctcaa aaatagttta tataatgatt tgaaaatcag
    12181 attgttgaaa atttcacgat tttaattaag gaacaaacaa gaaacaaaat cgttaattaa
    12241 aggtatttcc caattttttg ttttcactct gtttctttct ttgcacttgc ttataatcgg
    12301 gacttcttga acagcttccc accagatttt tttcgtccga tggttgcatg tgagcttcca
    12361 agaaccactg cagccaaaag aaaaaagcaa gtattcttta gttcatacaa agataaggaa
    12421 aaacttatag gcaggcaaat ttggctgcct aaatatagtt tactttgatt tagcatatat
    12481 ataggctaat ggactaaact aaaccttttc ccgaacttcg taaaacactc cggtcccatt
    12541 gtacagccaa aagaaaaaaa cattccacgt catatttttc ttttcgctgc aacccccttt
    12601 ttataaacca tcaacctttt acacgagatc ttctcttccc tgtgttcgca catccgcttt
    12661 cgggctgcct gatatgaatt gtgtcgcaaa ggtacttgtc atgtctttct tgtatgcaag
    12721 gtcaaagcct aacggttcac gacaaaatct ccaccctccg ttccgcacgg gtagtattta
    12781 atcgtgaaac cttgcataaa gagccatgac accttttgaa gcgacataat taaatcaagc
    12841 ccgaaagtag ctggatgcta caagagggaa aaaagaaaac ttaaaattca aagttatggc
    12901 aaactacgca acaaacattt tccacgcaag tacggaaaac aaacaagacc tcaataagat
    12961 agaggcattt ctggacgata atttcaacgg ctttgtcaac cggtatggcg acacggtaga
    13021 tgccgaattt gattcccgct gggaataccc ggaaaaagca atcaacgaat taatagcctt
    13081 attggcagcc aaagacaaaa tctatatccg catactgaca tacgagttag aggacgaata
    13141 cgtgagcttt cggatattct cgcaaggtaa atggaacatt aagttatcct aaacctaaac
    13201 acaattcact atgtacgaat acgaagaaga tagcgatatt atcggtttgt cctgcacgtt
    13261 gctcaatcca tataaaggtt acatggaagg cacaatcgtg ggcgactatg gcaataccat
    13321 agttgtccgc cttgaaagcg gcaaggaaat ttcagaatac cgtgatgaag tgattatcca
    13381 tgattaaacg atagcaaacg tatgacacag atagcaacaa aattcgtcaa atgggacatt
    13441 cccgaactgg cgacattgca ggacagcaag gtttacaaat tgcgggtaca cctgaacaac
    13501 ggaggcaagt taaaccggga agaaaagaac tggattaccc gtaacgtatg ggaaagtatc
    13561 tatttcaaac gtggaattgc cttgagcggt tatcactttg acttttccga catcctcaaa
    13621 cggtatttcg tcaaacagca cggaagtatt cacgagtatt atgcgattga caaaacagcg
    13681 ttacgctcga tactgtacgg cagaatagag gatattgtag aagtaagcgg ttaaaacaac
    13741 aaggatatgg gagaatacaa attttatcaa gaccgtaagg ttacaagttg ggaacgggat
    13801 tatttcagtg tgaaagcgga cagttatgaa gaagccgagg caatcgtccg ctcatggaac
    13861 tgtgaggacg tgtcgaacat cattgacaac cgtctttgct atgaagagtg gcaagcattg
    13921 accgatacat cggaatctat gctccccgaa gaaaacgacg gcaacccgac aatagaaatt
    13981 ttcaatcaag acggagaatc aataatgact aatgtacccg aaacacctca atcaaaccaa
    14041 tagaaccatg aacgtaacaa tcgaacacgt cttttgccgc tatagcgatg aagcggaaga
    14101 aatctatttc cgaatcatga acacgattct ttttgcaact gacgaaaccg aacttcgggc
    14161 aagtatggaa cgcttgaaga acgaaaccac gctcgacgac tatttcatat tcggatacgg
    14221 agcacaccat atctggataa agcaacggcg accgagcgat aaaaacagga ttttcaaaca
    14281 tcggattatg gtagcccatt tctgacagga acag
//
