LOCUS       gnlProkkaJEEINPAD_7    14314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JEEINPAD_7.
ACCESSION   gnlProkkaJEEINPAD_7
VERSION     gnlProkkaJEEINPAD_7
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:54:18
            Original ID  :: gnl|Prokka|JEEINPAD_7
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3495288
            Orig. end    :: 3509602
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14314
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14314
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             493..972
                     /locus_tag="ctg7_2968"
                     /transl_table=11
                     /translation="MHHEKKVSEHLDKMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMV
                     FVHVDPKERMEVLSFSTVSRYMVMRGESSPAVIPDEQMARFRFMLDYSEESISMNSSPL
                     ARGEKVRVIKGPLTGLVGELVNVDGKSKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             1410..3779
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 6.8e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg7_2969"
                     /sec_met_domain="Poly_export (E-value: 1e-15, bitscore:
                     55.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQKQLASELARKGVTK
                     EQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLEDHPTTQDLARGDQVF
                     GRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIRQQISPEGTINIQKI
                     GPVNLSGMTVSAANDYLKGALNKIYNGLNNTTDPTSDIRLTLGNIRTIQINVMGEVVQP
                     GTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRL
                     QEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQ
                     NGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNT
                     IRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYI
                     PSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDVSRRIKN
                     PRSIADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPGYQAQQNVAIEGEIL
                     FGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLG
                     EAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMV
                     PNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIV
                     PGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3790..4191
                     /locus_tag="ctg7_2970"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKRMIK"
     CDS             4188..4937
                     /locus_tag="ctg7_2971"
                     /transl_table=11
                     /translation="MTLGSYLDEESSPWWDYLIGFPGIVIGGVKSLFGEDTVPASGGRQ
                     GTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITAVIADSVVHKLQEYII
                     GYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVLQSVRAEQERLQNDMS
                     LAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGLKIYILLFVFLSVSGT
                     LVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2972"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.5e-14, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 205.1;
                     E-value: 2.2e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2973"
                     /sec_met_domain="CTP_transf_like (E-value: 7.9e-11,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 7.6e-118, bitscore:
                     391.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 4.4e-59, bitscore:
                     198.1, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKDKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8183
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2974"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.3e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-18, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8193..9314
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg7_2975_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2975"
                     /sec_met_domain="Aminotran_5 (E-value: 6.1e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8283..9290
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg7_2975_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg7_2975_Aminotran_5.1"
                     /locus_tag="ctg7_2975"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9311..9454
                     /locus_tag="ctg7_2976"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9657..9962
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_2977"
                     /sec_met_domain="Polysacc_synt (E-value: 2.6e-06, bitscore:
                     25.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKIELKRILPLSFILIFLSQYYSMVYCFFRLL"
     CDS             9980..11098
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_2978"
                     /sec_met_domain="Polysacc_synt (E-value: 2.3e-12, bitscore:
                     45.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAA
                     FISGVIGIWMAYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFG
                     SKLLISSLINTVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPIL
                     SSIQDDDKCLTNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILC
                     LDWMFDHLSQINLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYS
                     LIATYLNTYYTNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCI
                     TGMSFYILLSFLFKLDSFFCILTLIIKTKKHR"
     CDS             11370..12053
                     /locus_tag="ctg7_2979"
                     /transl_table=11
                     /translation="MYFFMCMCWTFFFNKVSFKDMLYAFFCFCRASKCFTATFYYDFSF
                     KKRSQQIICLGYYTPFKDDYHMGDHSYDKFRNTTCNSFDYSIATSCLSARIISIDCGIS
                     YDKFKVLGFPRNDLLISKNNCNVIKREISKFAGYDVTKYIVYTPTFRDYETVTEGNLRS
                     ILGYVDCDLLKLSKILLKFNAALILKLHPLQNKTVLKKIYPKVYLFLNKHINMDCMIFC
                     HFQME"
     CDS             12050..12352
                     /locus_tag="ctg7_2980"
                     /transl_table=11
                     /translation="MITDYTSTYFDFLLVNKPVIFNFYDIEEYRRVRGFSFEPIEFFCA
                     GDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLMNQFQDDNSTKRICDIFLNEI"
     CDS             12361..12795
                     /locus_tag="ctg7_2981"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFGENL"
     CDS             13106..14146
                     /locus_tag="ctg7_2982"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aggtgaaccg gatgaatttg tcttacgtaa agcggtgcgg agtaggtcag tgtatctgat
       61 ttagaagctt gatatacagt gtttatcggt gtgcgttact tcttaggtaa cggaatgatt
      121 catggcgcaa agatggacat atttatgaaa atacgcaaac aaaaatgaaa ttaatttcgg
      181 aaaatgaatc aaatgcaggc ataacaggcg gaaaatgaca atatccgtgt tatgtctttt
      241 tttattccaa ttcatgaaaa acaccttcac ttctgcttta tttcctgaat accagtcctc
      301 ttctgatgtt ttcgttgaaa aaagttccct tttctgcttg ccctatgctt gttcgttacc
      361 taagaagtaa cggataaaca tggggtaaaa aaatatgatt ttaagaaaaa gaaatcacta
      421 aatgctgggc ctattaatgg gacaggggaa ggcgtagcac actcaaaacg ctggtatgtt
      481 gctttggttc ggatgcacca tgaaaagaag gtttccgagc atctggacaa gatgggtatc
      541 gagaatttcg ttcccgttca acaggaattc caccaatgga gcgaccgtcg caagctggtc
      601 acctccgtct tgcttcctat gatggtcttc gtacacgttg accctaagga acgcatggaa
      661 gtcctgagtt tttctactgt cagccgttac atggtgatgc gcggcgagag tagtcctgct
      721 gtaattcctg acgagcagat ggctcgtttc cgtttcatgc ttgattattc ggaagaatcg
      781 ataagcatga acagttctcc tttggctcgt ggcgaaaagg ttcgcgtgat caaaggtccg
      841 ttgacgggtc ttgttggcga actggtcaat gtggatggta aaagtaagat tgctgttcgc
      901 ttgaatatgc tgggatgcgc ctgtgttgat atgcctgtcg gttatgtaga gccgattatg
      961 gcggctgttt aaggcaaggg atatggatgc tattatttta caagaaaata tagagggttt
     1021 attaagtttg gtacgtatgc tgcttcctgg tggggggagt gcaggctgcg tgtatttgga
     1081 tgatctttca gcattacaac gatccatcca cgaaaagatt aacgatttat attctcaacg
     1141 ggggagacac cggagcagga tgctaccctg tgtttggcca tccttcaggg atataatgtg
     1201 tcgatgtacg ccaatccgga agacgaagaa agaaaacagg ctgttttgac ccgttctctg
     1261 tctcttctcg atgttcttcc cccttctctt cttaagcaac agttatctgc cgtctgtcat
     1321 gggatgcagg aactgtgtga aatcaactga aactttttta tttgtcaatg aaaatacaac
     1381 gactttttag cattctacta ttttgtttga tgctgggaag tggctcgctt atggctcagt
     1441 ccatgagtga ctcacaggta ctggaatatg taaaagacgg catccgccaa ggcaaggaac
     1501 agaagcagct tgcttccgaa ctagcccgta agggtgtaac caaagaacag gcaatgcgtg
     1561 tgaagcagct atacgagcag cagaacaatg taaatacctc gaaatcaacg ggcacggaca
     1621 tcaacgaatc ccgcctgcgt gaagagacta agaagaatac ttccgatatg ctggaggatc
     1681 atccgactac tcaggacctt gcccgtggtg atcaggtctt cggacgtaac atcttcaata
     1741 cccgcaacct gacgttcgag cctagtgtca accttgccac tcctgccaat taccgtctgg
     1801 gtcccggtga tgaagtcatc atcgatatct ggggtgctag ccagaacacg atccgccagc
     1861 agatctctcc tgaaggcacc atcaatattc agaagatcgg tcctgtcaac cttagcggta
     1921 tgacagtctc cgccgccaac gactatctga agggcgccct gaataagatc tataacggtc
     1981 tgaacaatac taccgaccct acttccgaca ttcgtctgac gttaggtaat atccgtacta
     2041 ttcagatcaa tgtgatggga gaggtcgtgc agccgggtac ctacgccctt tcttccttct
     2101 ctaccgtctt ccacgcgctt taccgtgcag gcggcgtgag tgatatcggc agcctccgaa
     2161 acgttcagtt ggtacgcaac ggaaagaata tcgccaccat cgacgtctac gaatttatca
     2221 tgaaaggcaa cacacaggat gacatccgcc ttcaggaagg tgacgtggtt atcgtccccg
     2281 cctacgatgt cttggtaaag atcagcggca aggtaaaacg ccctatgcgt ttcgaaatga
     2341 agaaagacga gaaccttgcc actttaatca aatatgccgg cggctttgaa gccgatgcct
     2401 acacccgttc attgcgtgtt gtccgtcaga atggtgagga atatgaggtc aacacggtca
     2461 aggatatgga ctacagcatc tacacaatgc gtaacggtga cgttgtaaca gccgaagcca
     2521 tccttaaccg cttcacaaac aaactggaaa tccgtggcgc tgtctatcgt cccggtatct
     2581 accagctcag cggtaaactg aacacgatcc gcgaacttgt ccatgaagct cagggtctga
     2641 ccggtgacgc tttcctgaat cgtgccgtcc tttatcgcca gcgtgaggat ttgaccagtg
     2701 aagttgttca gatagacatc aagtctatca tggacggtac ttccccgaac cttgccctga
     2761 tgaagaatga catcctttac attccgagca ttcacgatct ggaagatcgt ggcaatgtca
     2821 cagttcacgg tgaagtcgcg caccctgatt cctatcccta tgctgataac atgacacttg
     2881 aggacctgat catccaggcc ggtggcttga aagaagctgc ttctactgtc cgcattgatg
     2941 tgtcgagacg aatcaagaat ccccgtagta tcgcggataa tgatactatc ggtcagatgt
     3001 ataccttctc tttaaaggat ggttttgtca tcgacggtca gcccggtttt atccttcagc
     3061 cttatgacga agtttatgtc cgtcgcagtc cgggctatca ggcacaacag aatgtagcca
     3121 ttgaaggtga aatccttttc ggaggaaatt acgccatgac cagccgtgag gaacgtcttt
     3181 ccgatttagt gaataaagcc ggcggtccga ccaattatgc ctatctgcgt ggtgcgaaac
     3241 tgacccgtgt ggctaacgct agtgaaaaga aacgtatggg tgatgtaatt cgccttatga
     3301 gcaggcaatt gggcgaagcc atgattgact ctttgggtat tcgtgttgaa gatactttta
     3361 cggttggaat agatttggaa aaagccttga gcaatcctaa aagtaatgcc gatcttgtct
     3421 tacgtgaagg tgatgtgatc tccataccta agaatactaa tactgtaact atcaatggtg
     3481 ctgtcatggt tccgaatacg gtttcttata tgaagggaaa gaatgtggat tattacctga
     3541 atcaggccgg tggctgttct gataatgcaa ggaagagtaa gaagttcatt gtttacatga
     3601 atggtcaggt gacgaaggtt aagggtagtg gtaagaaaca gattgagccg gggtgtgaga
     3661 ttattgtgcc tggtaaggct aagaagaaag ggaacatagc taatatttta ggttatgcta
     3721 cttccttcag ttctttggga atgatgattg cttctattgc taatttgata aagaaataaa
     3781 tgacctatta tgattgaaaa gcaatcttat caagaaccgt tttctgaagt ggataaaagg
     3841 aaagatgatg aaatggaaat agacttgatg gctatttttt ataagattat tactgttcgt
     3901 ggagtactat gcaaagctgc tggagtggga gtaataattg ctatagtggt ggcattgagc
     3961 attcccaagc aatatacagt aaaggttacc ctttctcctg aaatgggtaa tgcgaaggga
     4021 agtaatggtt tagccggact tgctgcctcg tttttgggag atggggctct aataggggaa
     4081 agcacagatg ccttgaacgc ttctctttca gcagatattg tttcttcaac tcctttttta
     4141 ttggaacttt tagaaatgga agtctccgtt tctaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgttttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttacatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtga cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaataact ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccctgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaagataaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tttcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacag atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agataatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaaag aaatattgga
     7021 actgattcca ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     8041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     8101 aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     8161 attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa
     8221 atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt
     8281 gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag
     8341 ttgctcatgg gaatttggaa aaacataccg ctgtattatt ttgtggctca ggaaccatca
     8401 atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata
     8461 atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta
     8521 atttggaatt ttccgtttac gaacgtcctg atttatcggt ggtggaaaat gtgttgcaag
     8581 aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga
     8641 accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata
     8701 ctacttcttc tttgggcatg attccttttg atatagagaa agataatgtg gatttttgta
     8761 tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg
     8821 aggaacagat taagttttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt
     8881 tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta
     8941 tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggtgaagaa gctaagtttg
     9001 cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa
     9061 gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc
     9121 ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc
     9181 caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag
     9241 atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat
     9301 taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg
     9361 tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt
     9421 agtaggcaaa tatggcaata ttaatttgag gtgatgcatt aggagttctt tattcttata
     9481 aaaaggcatc ggtagttata ggagataatg tttgtgtagg gtaatttgct tttagtggga
     9541 gagaccatat tagaattgcg gtaaggggcg aagaagataa taaccaatta gtgagaatat
     9601 tggaaaaata taattgatat cggtaaatgt agttgttttt atactgtatt taagtaatgg
     9661 aaaatctaaa gcagaaaact gtatcaggaa taatgtggag cgctatagaa cgtttctctt
     9721 tacaaggagt acagtttata attcaaataa tattagctcg tttgttacta ccatcggatt
     9781 atggtatgat cgggatgtta gctatttttc ttcaagtcgc tcaagtattt atagatagcg
     9841 gttttacaaa tgctttaatc cagaaaaaga tagaactgaa gaggattttg ccactgtctt
     9901 ttattttaat attcttgtcg cagtattatt ctatggtata ttgttttttt cggcttcttt
     9961 gattgcagac ttttataata tgccgacttt agttcttgta attcgtttta tagcattgtc
    10021 gttgataata aatgctttat cggctattca cagaacgaaa ttaattattt ctgtaaactt
    10081 taaaactcaa tctaaaattt cattaggtgc agcttttata tcaggcgtga ttggaatatg
    10141 gatggcttat gtcggttgcg gggtttgggc tttagtttgg caaactctct taaatagtat
    10201 aattttgaca attttgtttt actgtttagt tcattggaaa cctttacata ctttctccaa
    10261 aagttctttt gaaagattat tcaatttcgg atctaaatta ttgatctcaa gtcttatcaa
    10321 tacagtatat cgtaatctgt ataccattgt aataggaaaa aagttttctg ttgtagagct
    10381 tggttactat acaagagcag aacaatttgc tatttttcct tccaataatt taaatgcttt
    10441 agtttctaga gtagcgtatc ctattttaag ttccattcaa gatgatgata aatgtttaac
    10501 aaacgcatat cgaaattata tcagattatc ctcatatata atttttcctt taatggtagg
    10561 tttacttgtt ttggctaatc ctattattag tctattgtta acagataaat ggtctggggt
    10621 tgttattctt ttacagatat tatgtttgga ttggatgttt gatcatttga gccaaattaa
    10681 tttgaattta ttatgggtta aaggaagatc tgatctgtcg ttacgtcttg aaataataaa
    10741 aaagacgatt gctatattca ttctttttgt gtcaattcca tttgggcttg aggtgatgtg
    10801 ttggggtaga gttatttact ctctgatagc gacatatttg aatacatatt atactaattc
    10861 tcttattgat ttgaccttaa agttgcaagt taaagatgta tttccaagtt taatactctc
    10921 tttcataatg ggggggatcg tttttatatg tatttctttc tttgaaactg atatagtaaa
    10981 aattgtgatt ggatgtatta ctgggatgtc cttctatatt ttactttctt ttctttttaa
    11041 gctagattct tttttttgta ttttaacatt gatcattaaa actaaaaaac atagatgaaa
    11101 atattaaaaa agatttttca agtaatagta aagataatta accattgtgt gccagttgat
    11161 agtagatcat tgtattttat tcctcatcct aattgtagaa cagataaata tgatattata
    11221 aattattcgt cagataatgt tctcgttctg ttaaattatt tgctaaaaaa agatagtgct
    11281 gaatattata aaatatatgt tgaaatttat gattcttctc gtatttcaga atatcaagaa
    11341 tatatttatg gcataaatcc taatattagg tgtacttttt tatgtgcatg tgttggacgt
    11401 ttttctttaa taaagtatct tttaaggata tgttgtatgc ctttttttgt ttttgtagag
    11461 caagtaaatg ttttacagct actttttatt atgatttttc atttaaaaaa cgctctcaac
    11521 agattatttg tttggggtat tatactccat tcaaagatga ttatcatatg ggagatcatt
    11581 cttatgataa atttcgtaat acaacatgta actcatttga ttactctatt gctacttctt
    11641 gtttaagtgc tagaataatt tcaatagatt gtggaatctc atatgataaa ttcaaagtct
    11701 taggatttcc cagaaatgat ttgttgatat cgaaaaataa ttgcaatgtt attaaaagag
    11761 aaatttcgaa atttgcggga tatgatgtaa ctaaatatat agtttatact ccaacttttc
    11821 gtgattatga gactgttact gaaggtaatt tgcgttcaat actcggatat gttgattgtg
    11881 atttgttgaa gttatcgaaa atactattga agtttaatgc ggctttaatt cttaaattac
    11941 atcctttgca gaataaaaca gtcttaaaaa agatttaccc aaaggtatac ttgtttttga
    12001 acaaacatat aaatatggat tgtatgatct tttgtcattt tcagatggaa tgattactga
    12061 ttatacttct acctattttg attttttatt ggtaaataag ccagtcatat ttaatttcta
    12121 cgatattgaa gaatatcgta gagtaagagg tttctcattt gagccaatag aatttttttg
    12181 tgcaggtgat attgtttaca attataatga attgatagat gctgtgatgg gacttctggc
    12241 tgggaaagat attcatgctg aacatcgacg tcatatttct ttattgatga atcaatttca
    12301 agatgataat tcaacaaaga gaatatgtga catattttta aatgaaatat aataaataaa
    12361 atgaattatg catttgtggt gcaggcacgt ttaggttcta cacgtttgcc tggaaaaata
    12421 ttgaaacctt tctatggtaa tcaatcgatt cttgacttaa tggttcataa gctttctgct
    12481 atatcgaata ttccagtaat tattgctaca acaaattctg ttatcaatga acctattgaa
    12541 aagaaggcac ttgcattagg ggtaaagtgc ttcagaggtg aggagaatga tgttttaaaa
    12601 cgattcattg atgttgctga atattttgat atacagggta tattccgaat atgttctgat
    12661 aatccatttt tagatgtaca tgcggcaagg caattggtcg aaatagcaat gaaatcttgt
    12721 aacgattata taagttttga tattgatggt actccatcaa ttaaaactca tttcggtttt
    12781 ggggagaatt tgtaacgctt gatgcgctga agcgagttat aggatttact gatgatttat
    12841 tgtatcgtga acatgttact aattatatat atagtcatcc tgaacttttt aatattcaat
    12901 ggatttcagg atctccagtc gtgtcaaaac atcataatat tcgactcacg attgatacgt
    12961 tagaagattt ttctgtagca cagagaatat atagggattt acaagaaaaa gagtggaaat
    13021 atcgatagaa gtgattgtag actatgttcg aagacatgca gaatacattc aactgatgaa
    13081 acaacaaata aaaaaattct aaataatgaa gaatacttat attattggtg aaatagggca
    13141 gaatcataat ggttctgttg acttggctaa gttgattatt gaattaatct cacgacctgt
    13201 acatgaggat gtttttggta tggatttcat gccaatgaat gctgttaaaa tgactaaaag
    13261 agatttatca gaagaattgg ctgtttctca aatgaatcaa atatatgaca atcctaattc
    13321 ttttgggcgt acttatggtg aacatcgtgc ttttcttgag cttgatgatc aagcgcattt
    13381 tgagatttat aaatatgcta agtcattagg attagatttt atcgagacgt tatgtgccaa
    13441 aggatgtctg tctttgctta aactgttcac accggatagg ctaaaagttg ctagtcgtga
    13501 tttgactaac ttaccattgc ttgaagcatt agcagaaact catattccta ttatattatc
    13561 gacaggaatg gctggtcaaa gagaacttga caatgcatta gatgtgataa cgagatatca
    13621 tagtaatata gctattctac attgtgtatc tcagtatcca actcatccaa ataatttgaa
    13681 tctacgtaca ataacatatt tgaagaagca ttacaataag tttgagatag gtttttctga
    13741 tcatacaata ggtatttctg ctgctacagc tgctgtagcg atgggagcgg aaattataga
    13801 aaagcatgta acaattgatc ggcatatgaa aggaacagac cagcttggct ctttaggtcc
    13861 agatggggtt aatcgtatga ttcgagatat tcgcatagca gagtgttggc ttggtactga
    13921 agatctttat atagaaaaag gggtggagaa gtctaagata aaacttgaac gttctattgc
    13981 cactcgaaaa tatattccag caggtagtat tattcaagag tcggacattc atttactgag
    14041 tcctggtgat ggttataaat ggatagataa aaaaaatgta attggtcatt ttgctaaaca
    14101 agatatatca gcgaatgaaa taatatatcc tgattttatt gaatagatat attcctactg
    14161 caacttgtat tacggtatag agtactgcct gctataagct aagtagtgat taataaataa
    14221 gggtaaaata ctaaaaaaat gaaagagata aagcttatac ttacagatat tgatggcgtt
    14281 tggactgatg gcggaatgtt ttatgatcaa acag
//
