LOCUS       gnlProkkaLBBFHEIB_4    14314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LBBFHEIB_4.
ACCESSION   gnlProkkaLBBFHEIB_4
VERSION     gnlProkkaLBBFHEIB_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 12:55:37
            Original ID  :: gnl|Prokka|LBBFHEIB_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3014641
            Orig. end    :: 3028955
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14314
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14314
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(638..1762)
                     /locus_tag="ctg4_2433"
                     /transl_table=11
                     /translation="MWLAIFIICVIPFITVLVNRATIEYNAIKRYAGVSLYMSSKSIIV
                     IGYFIVFFFISAFRSANVGCDTQSYLDLFDKVANSGYYIGDTRYEIGYVYLNKLVAFLY
                     DSHFFFLFFTSFLLMLGYAIFIRKLSKIIWLSFFLFFTLRYFDQSMNLLRQNFAIILIF
                     ISYLRLRKKKIYQSILWTFLASCFHLTAITFLLGILAYKMCNWNLNKILLCFSLLGIVL
                     YIACGSLTNLIFNNIASYASYANSVYNEGGARIAVVLQLLMSLLVITGGILCNRTDYER
                     EDYTENKMLLLLLLFGVMFLILSLQFNQMTRLASYFSVFAIIYLPNSLIAVSKKKRFIG
                     YILIFLVGVSSYLMINMLRPQWAGIYPYTFSFLN"
     CDS             complement(1762..2877)
                     /locus_tag="ctg4_2434"
                     /transl_table=11
                     /translation="MWKYDGLFKLLVKDSRFIPYIIPVLNPHDSLDLQEKHQKEMKDYF
                     LTYKSYSFVEGYDFQKQEIFDPLKLTPDLIFYTQPYNQGYSVCRIEHLWQNALFLYTPY
                     AFWIEKGSWGYNGLLHNIAWKLFYPTQIHLEHAQKYSWVKGVNVVVTGYPLADIFGDTR
                     RKSKNLWKTQKKDLKKIIWAPHHSILKDDTLDYSNFLNIAEDMLNIASKYKDYIQIAFK
                     PHPHLKRKLYKMQGWGIEKTNQYYLKWNELPNTILVEGDYIDLFMTSDAMIHDCSSFSV
                     EYLYVNKPVLYLTKNNHLDFLCNFGEMAFNMHYKGSTVGDVEKFLKNVILDGCDSMKMQ
                     RNMFMIKYLLPSHGINVAENMFNEVVAPWNK"
     CDS             complement(3059..4489)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_2435"
                     /sec_met_domain="Polysacc_synt (E-value: 1.1e-34, bitscore:
                     117.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKNIRKQTLLGIAWSAIERFSLQGVQFLVTLVMARFLLPSDYGM
                     IGMLTIFLQLSQILIDSGFANALIRDKERTETDFSTIFYFNILVAVLLYILLFLSATYI
                     ADFYGLPQLVHIIRVISLVIILNSLVIVHRTRLIIDIDFKTQSKISFLSAFLSGVIGIW
                     MAYTGYGVWALVVQVLLNGLLVVCFYVYFCRWKPHWEFSISSFKRMYSFGGKLLISNIL
                     HTLYKNLYTVVIGKRFSAIDLGYYTRAEQFAQFPSSNLNAIVSRVAYPILSSVQDNDKI
                     LVSIYRKYIRVISFVIFPLMIGLAALSKPLVLILLTDRWISVVLLLQILCFDWMFDHIS
                     AINLNLLYVKGRSDLALRLEVIKKTIATAILFLSIPFGLIGICLGRVLYSLIATYLNTY
                     YTQSLIGLSFGSQLRDIFPSFFAAVCMGLCVYFSMNLFSKDLVQLLMGVIMGILSYLLL
                     SRIFLMSILKELFSLSKK"
     CDS             complement(4534..5004)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73;
                     E-value: 4.1e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_2436"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFFLRGIHFHPESVIAGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGSVVTKDIPSGVLVAGVPAIVKKKLI"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-344). E-value: 2.8e-33.
                     Score: 107.2. Matches aSDomain:
                     nrpspksdomains_ctg4_2437_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 73; E-value:
                     3.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2437"
                     /sec_met_domain="Aminotran_5 (E-value: 3.9e-28, bitscore:
                     95.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPDDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGDIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKVSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHL
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWNFEKIHDYCYERGFTIYPGKISTANTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5091..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_2437_Aminotran_5.1"
                     /evalue="2.80E-33"
                     /label="ctg4_2437_Aminotran_5.1"
                     /locus_tag="ctg4_2437"
                     /protein_end="344"
                     /protein_start="30"
                     /score="107.2"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPDDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGDIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKVSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHLGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WNFEKIHDYCYERGFTIYPGKISTANTFRICAL"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.4;
                     E-value: 1.2e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2438"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.6e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.1e-19, bitscore:
                     65.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIARGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..8574)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2439"
                     /sec_met_domain="CTP_transf_like (E-value: 4.7e-11,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4.9e-119, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5.5e-61, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8595..9314)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2440"
                     /sec_met_domain="NTP_transf_3 (E-value: 8.8e-15, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9378..10526)
                     /locus_tag="ctg4_2441"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSELDKRKDDEVEIDLMAIFYKIITVRRVLYKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNTKGTNGLAGLAASFLGDGAAIGESTDALNA
                     SLSADIVSSAPFLLELLEMEVSVSKKDDKMTLESYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTIPAGGGRQGAIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10537..12948)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_2442"
                     /sec_met_domain="Poly_export (E-value: 2.6e-16, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(12966..13280)
                     /locus_tag="ctg4_2443"
                     /transl_table=11
                     /translation="MLLPGGGSAGCVYLDDLSALQRSIHEKINDLYSQRGETPEQDATL
                     CLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGMQELCEIN
                     "
     CDS             complement(13345..13923)
                     /locus_tag="ctg4_2444"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 ctgtatatag ccagacgtca cacagtgtac ttcatattta ttcctaggta tagtatataa
       61 gtgatctata cctttattag catcagcacg tcccacaaac aaaatcagct tcttattttt
      121 aggttctttt attcttaaat cagggaattg ttgaagccaa ttaggtatac atacaacatt
      181 cttatgaaac cttttaaaga aagcagtatc ttctttgttt atggtcgtta ttgtttttac
      241 ataataaaga caaggacgaa gtaataagaa aaagtatatt ttagctaaca aaggatgatt
      301 caacttctca aatggatgga aatgcggtgt atacacaatc ttcttacgta aaagaataga
      361 tattataaaa aattgtaaaa caacaataga agcgaatcca ttaatatgaa taatatcaca
      421 ttttcttaaa tcattatatt taaacaaatc tgtaaatgaa tatattttct tacctaacaa
      481 tttgaaagac tttaatcgta ttcgactgta atcaatttga attacttcca ccttagaatt
      541 agcagtaaaa agctcaacta gattctcgca atatcgatta atccctgcac acaaagaaga
      601 tgcttttaca tccaataaaa gtactgatct catgaattta atttaaaaaa gaaaaggtat
      661 atggataaat tcctgcccat tgcggacgta acatattaat catcaaatag gaactaactc
      721 caactagaaa tattaaaata taccctataa agcgtttttt tttagataca gctataagac
      781 tattaggtaa ataaatgata gcaaaaacag aaaaataaga ggccaaacga gtcatttgat
      841 taaactgtaa agaaagaatc aaaaacataa ctccaaataa caataataat aataacatct
      901 tattttctgt gtaatcttct ctttcatagt ctgtacgatt acacaaaatc ccccctgtga
      961 taactaaaag agacatcaat agttgcaaaa cgacagcaat tcttgctcca ccttcattat
     1021 aaacactatt agcataagaa gcataactag caatattatt aaatatcagg ttagttagcg
     1081 aaccacaagc tatatacaat acaattccca ataaactaaa gcatagcaat attttattta
     1141 aattccaatt acacatttta taagccaata tacctaataa aaaggtaata gcagtaagat
     1201 gaaaacatga agcaagaaat gtccataata tagattgata aatctttttc tttcgcaaac
     1261 gcagataaga gataaaaata aggataatag caaaattttg tcttagcaaa ttcatacttt
     1321 gatcaaaata ccttagtgta aaaaacaaga aaaaacttag ccaaattatt ttagataatt
     1381 tacgtataaa aattgcatac ccaagcatta gaagaaaact tgtaaaaaat agaaagaaaa
     1441 aatggctatc ataaagaaat gcaactaatt tatttaaata aacataacct atctcatatc
     1501 ttgtatctcc aatatagtaa cccgaattag ctaccttatc aaaaagatca agatatgatt
     1561 gagtatcaca tccaacattg gctgatctga aagcagaaat aaaaaaaaag acaataaaat
     1621 atcctattac aataatagat tttgaggaca tatacaaaga taccccagca taccttttta
     1681 ttgcattata ttcaattgta gctctattaa ccaacacagt tataaatgga ataacacaga
     1741 ttataaatat tgctaaccac atcatttatt ccatggagcc actacctcat taaacatatt
     1801 ttccgcaaca tttattccat gcgatggaag taaatatttt atcataaaca tatttcgttg
     1861 catcttcatt gaatcacatc catcaagtat tacatttttt aagaatttct ctacatctcc
     1921 caccgtactt cctttataat gcatattaaa tgccatttct ccaaaattac ataaaaagtc
     1981 taagtgatta ttctttgtaa ggtacagaac aggtttattt acgtataaat attccacaga
     2041 aaaagaacta caatcatgaa tcatggcatc cgaagtcata aataaatcaa tataatctcc
     2101 ttcaaccaat attgtattag gaagttcatt ccattttaaa taatactgat ttgtcttttc
     2161 tatcccccac ccttgcattt tatataattt tcttttcaaa tgtggatgag gtttaaatgc
     2221 aatttgtata taatctttat atttactagc aatattaagc atatcttcag caatatttag
     2281 aaagtttgaa taatccaatg tatcatcctt caatattgaa tgatgcggcg cccaaataat
     2341 tttttttaaa tctttttttt gtgttttcca taagttttta gattttcttc ttgtatcacc
     2401 aaagatatct gccaaaggat atccagtaac tactacattt actcctttca cccaagaata
     2461 tttttgtgca tgttccaagt gaatttgagt aggataaaat aatttccaag caatattatg
     2521 caataaacca ttatatcccc agctcccctt ttctatccaa aaagcatatg gcgtatacaa
     2581 gaataatgca ttctgccata aatgctcaat tctacacaca ctatagcctt ggttatatgg
     2641 ttgggtataa aagattaaat ccggagttaa ctttagtgga tcgaagattt cttgtttctg
     2701 aaaatcatat ccttctacaa aggaatatga tttgtatgtt aaaaagtaat ctttcatttc
     2761 tttttgatgt ttttcctgca aatccaaact atcatgcgga tttaaaaccg gaataatata
     2821 gggaatgaaa cgagaatctt tcactaacaa cttaaacaag ccatcatact tccacatcga
     2881 aatatctgtt acaagaaaaa gaacgtttat tttcttctta ctaaatatct ccttttctaa
     2941 agatggtatt ctttgcctat accttcttat ttttccccgc ataaaaaaac acttgatagg
     3001 ccaatagaaa ctgaaaggaa caaacctttt tactatcttt attataatac ttaacatttt
     3061 acttcttgga taaagaaaac aactctttta atattgacat tagaaatatt ctgcttaaaa
     3121 ggagataaga taatatcccc attattactc ccattaataa ttgaaccaaa tcttttgaaa
     3181 acaaattcat gctaaaatag acacagagcc ccatacatac agctgcgaaa aagctaggaa
     3241 atatatctct caattgtgac ccaaagctaa gaccaattaa tgattgagta taatatgtgt
     3301 tcaagtatgt agcaatcaga gaatacagaa ctcttcccaa acatatccct attaatccaa
     3361 aaggaataga caaaaaaaga atagctgtag caattgtttt ttttataacc tctaaacgca
     3421 gagctaaatc tgaccttcct ttaacatata ataaattcag atttatagcg ctaatatgat
     3481 caaacatcca gtcaaaacat aaaatttgaa gtaaaagaac aacactaatc catctatccg
     3541 ttaacaatat aagaaccaat ggtttagaca aagctgccaa tccaatcatc aatggaaaaa
     3601 taacaaatga aataacacga atgtactttc tatatataga tacaagaatt ttatcattat
     3661 cttgaacaga actcaatata ggataagcaa cccgcgaaac aatagcattc aaattagaag
     3721 aaggaaactg agcaaactgc tctgccctag tataataccc taaatctatt gctgaaaatc
     3781 ttttcccaat gacaacggta tacaaattct tatataacgt atgtaggata ttagatataa
     3841 gaagctttcc accaaatgaa tacatccttt tgaaggaaga gatagaaaac tcccaatgag
     3901 gtttccagcg acaaaaataa acataaaaac aaacgactaa taaaccattt aaaaggactt
     3961 gtactaccaa cgcccaaact ccataacctg tatatgccat ccaaatgcct attacccctg
     4021 aaagaaaagc agataaaaaa gaaatctttg attgagtttt gaaatcaata tcaataatta
     4081 aacgagttct atgtactatt accaacgagt tcaatattat caccaacgaa attactctga
     4141 taatatgaac caactgggga agaccataaa aatcagcgat ataggtagca gatagaaata
     4201 aaagtatata caataatact gctaccaaaa tattaaaata gaaaatcgtt gaaaaatctg
     4261 tttctgtacg ttccttatcc cgaataagtg cattagcaaa tccgctatct attaaaatct
     4321 gagataactg aagaaaaata gtcagcatcc caatcattcc ataatctgaa ggcaaaagga
     4381 aacgagccat taccaaagtt actagaaact gtactccttg taaagaaaaa cgttcaattg
     4441 cactccaagc aatacccaat agcgtttgtt ttctaatatt ttttaacatt cacttctttt
     4501 tatccaaaca aaagcatata aaaacaacca atatcaaata agtttttttt tcacaatagc
     4561 tggtacacca gctaccaata ctcctgaagg tatatctttt gttacaacag atccagctgc
     4621 tactacaacg taatcaccaa tagttactcc aggaaggatg gtaacattag ccccaatcca
     4681 aacattatct cctataacta ccggtgcctt tttataagga taaagaactg ctaatgcatt
     4741 atacggtcca ttaggatcag cagttgtcaa tatagtcgtt ccataggcga gtgttgaatt
     4801 ttctccaata atgattttat cacgagcaat cagataacag cctgaacgta tttcagcatt
     4861 tttacccaag tagatattgc tatatttgcc tactaagcga aagctacgaa taggaactcc
     4921 agcaataaca ctttccggat ggaagtgtat accacgaagg aaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatttctcc taaagcacag
     5101 attctaaaag tattcgcagt cgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaattccag ttgggatctt ctgggtattg aactgagaca
     5221 accaatcctg actgccattc acgctttatt acacttttaa gacctatttc atttatacct
     5281 aaatgaatag cctcaaaaac tcttttgtga cgggcaaatt tagcttcttc acccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaac cttaatctgt tcctcattgc ctataataaa agaaagacca
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatcaacatt atctttctct
     5581 atatcaaaag gaatcatacc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tatcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcatga
     5701 tgagtagtat aaaccatagc tatatctgga ttttcttgta acacattttc cactactgat
     5761 aaatcaggac gttcataaac agaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgtgt actatatgcc ccattattca ctataagcac ccttttgtcg
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagctgtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct atcttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccgggca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccgaattctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttttttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 gtattcctct ttttatttag tacccggaat cagttccaat atttccttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt atctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc ctgctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatccgtac caaacaatga attctttttt aatccaactt tatcttcaat
     7801 tattatagct gagattccat gacgttctaa agtgcgtact gtaaatacga aatgttcaat
     7861 tttaccacct gtatctccat caaaaataat aggtttagta gtacactcca gaatattatt
     7921 caaatcttgc aatcgggtag ttaaatcaac cgcctcaata tcaggtttac ctttactggt
     7981 tgaatccgta aggctactag accacattcc gtcaaatact tccctcttat ccccttttaa
     8041 tatttcctga ttttcaatta tcaagccaca tagtccatca tgagcttcca aaatacgaac
     8101 tacgggtttg gcatttatca aacgacgaag tgattttaaa cgtacatcgg gggttgtacc
     8161 tatagcctta atatctttat ccaaagaaga tgaattaatt cccaaagtat atggaatttc
     8221 gataaccttt cctccctgtt cattcatcac ttcaaatacg cgcacacgtt cttcacgtaa
     8281 aggcccggtt ttccagtcgt caccatgaat tatatagtca ggtttaatgc gtttgagatt
     8341 ctcaacatag ctccattctt cttgaggaac aactttacat acgcctttaa tattctgaac
     8401 tacctctttt cgttgttcat aggtcagata aggaaggcgt ttatgctccg caatagcttt
     8461 atctgtaaga agaccaatta taacatcacc gtatttagta gcctcattaa taatgcggat
     8521 aagtcctgga tgcataatat ccgcagtcat cccaatataa actgtcttac tcataatttg
     8581 atatattatt ttaattaaca atacggaaca atatatttct ctgcatattc caaatctgat
     8641 atgtcatcga tttcatacca tttcagccct tctactttat gcacataaac aggagattga
     8701 gaacaagata ttcgtagtaa ttcatactca tatcccaaat tgggttgttc atcaacaata
     8761 ctcgcataat cagcacacat tattttgtaa aaggaaccgg atagtttatg gatgccgacc
     8821 aattcgcctt tagcgtttag tttattctta ttgacagaac atgaagaaag gcgaaaatta
     8881 tcatcatgtt ccacataata ctgatcttga aactttgtca ctggagctat tagcattgca
     8941 tctgccgcag gacactccaa taagctcatt attgcttgtt tctcaaaaat caaatctgac
     9001 tctaacaata aaaaatcatc attgcccaga atctcccgcg tattatataa agtatacata
     9061 ctatttgttt cagcataacg aggactaaaa caggtttcaa gcataggata gtctgtcttc
     9121 aattcttcat aaacttcttg tttatatcct gtaccgatta caattcgctc aatgccacat
     9181 gataacaaag tatcaataga acgaactatc attggaatac ctcccacttt gacgaaccct
     9241 ttaggtatca attctgtata ttggccaaaa cgggttccca tgcccgcagc cattatcata
     9301 gctgtacgta tcattcgttt aataatatag taagtgaatt taattgatgt aagaatgttg
     9361 taaacgacgt tttagcatca tttatcctgt tctatctcct tatttttcag ttcttttctc
     9421 aagctagcca gcagactttt gccaaaaaac acccacacga gagtaccaga tacggacagg
     9481 aacacaaata ataaaatata aattttgagt cccatacctg aaggtttcaa aggtacaacg
     9541 gcaggctcaa ctactgcaaa gactggcttt tcctcctgta ctttggctct ggatacctgc
     9601 aactgattag caacctgact atatatctga taagccaaac tcatgtcgtt ctgtaaacgc
     9661 tcctgctcag cacgtacact ttgaagaacc acattatcat gggcgtctac ataatccgca
     9721 tattttcttt gagcagcata atattcctgc tgacgttctt taaacaaccg ttccaaatac
     9781 gcacagtctt cttttacttt tgaagttcga tacccaataa tatattcctg taatttatga
     9841 acgacagaat ctgctataac cgcagtgatc tgcggatttt gtaaggtgac cgtaatgctc
     9901 gttatggcgg ttttcttatc aatggatgca ctaatcttct ttttaagaaa attaatcttc
     9961 tcatttactt ctttcgtcaa ttcaatagct ccttgccgcc ctccaccagc aggaatcgta
    10021 tcttctccga ataatgattt tactccccct attactatgc ccggaaaacc tataagataa
    10081 tcccaccaag gagaggactc ttcatcgaga taagactcca aagtcatttt atcatccttt
    10141 ttagaaacgg agacctccat ttctaaaagt tccaataaaa aaggagctga agaaacaata
    10201 tctgcagaaa gagaagcatt caacgcatca gtgctttccc ctattgcagc cccatctcct
    10261 agaaatgaag cagccaatcc cgctaaacca ttagttccct tcgtattacc catttcaggg
    10321 gaaagagtaa ccttaactgt atattgctta ggaatgctca atgccaccac aatagcaatt
    10381 attaccccca ctccagcagc tttgtatagt actctacgaa cggtaattat cttataaaaa
    10441 atagccatca agtctatttc cacttcatca tctttccttt tatccaattc agaaaatggc
    10501 tcttgataag attgtttttc aatcataata ggtcatttat ttctttatca aattagcaat
    10561 agaagcaatc atcattccca aagaactgaa ggaagtagca taacctaaaa tattagctat
    10621 gttccctttc ttcttagcct taccaggcac aataatctca caccccggct caatctgttt
    10681 cttaccacta cccttaacct tcgtcacctg accattcatg taaacaatga acttcttact
    10741 cttccttgca ttatcagaac agccaccggc ctgattcagg taataatcca cattctttcc
    10801 cttcatataa gaaaccgtat tcggaaccat gacagcacca ttgatagtta cagtattagt
    10861 attcttaggt atggagatca catcaccttc acgtaagaca agatcggcat tacttttagg
    10921 attgctcaag gctttttcca aatctattcc aaccgtaaaa gtatcttcaa cacgaatacc
    10981 caaagagtca atcatggctt cgcccaattg cctgctcata aggcgaatta catcacccat
    11041 acgtttcttt tcactagcgt tagccacacg ggtcagtttc gcaccacgca gataggcata
    11101 attggtcgga ccgccggctt tattcactaa atcggaaaga cgttcctcac ggctggtcat
    11161 ggcgtaattt cctccgaaaa ggatttcacc ttcaatggct acattctgtt gtgcctgata
    11221 gcccggactg cgacggacat aaacctgatc ataaggctca aggataaaac cgggctgacc
    11281 atctattaca aaaccatcct ttaaagagaa ggtatacatc tgaccaatcg tatcattatc
    11341 cgcagtacta cgaggattct tgattcgtct cgacacatca atgcggacag tagaggcggc
    11401 ttctttcaag ccaccggcct gaatgatcag atcctcaagt gtcatgttat ccgcataagg
    11461 ataggaatca gggtgggcaa cctcaccgtg aactgtgaca ttaccccggt cttccaggtc
    11521 atggatactt ggaatgtaga ggatgtcatt cttcattagg gcaaggtttg gggaagtgcc
    11581 gtccatgata gacttaatgt ctatctgaac aacttcactg gtcaggtctt cacgctggcg
    11641 atagaggacg gcacgattca ggaaagcgtc accggtcaga ccctgagctt catggacaag
    11701 ttcgcggatc gtgttcagtt taccgctgag ctggtagata ccgggacgat agacagcgcc
    11761 acggatttcc agtttgtttg tgaagcggtt aaggatggct tcggctgtta caacgtcacc
    11821 gttacgcatt gtgtagatgc tgtagtccat atccttgacc gtgttgacct catattcctc
    11881 accattctga cggacaacac gcaatgaacg ggtgtaggca tcagcttcaa agccgccggc
    11941 atatttaatg agagtagcaa ggttctcgtc tttcttcatt tcaaaacgca taggacgttt
    12001 taccttgccg ctaatcttta ccaatacatc ataggcagga acaatcacaa cgtcaccttc
    12061 ctgtaggcgg atgtcatcct gtgtgttgcc tttcataatg aattcgtaga cgtcgatggt
    12121 ggcaatattc tttccgttgc gtaccaactg aacgtttcgg aggctaccga tatcactcac
    12181 accgcctgca cgataaagcg catggaagac ggtagagaag gaagaaaggg cgtaggtacc
    12241 gggctgtacg acttctccca tcacattaat ctgaatagta cggatattac ctaacgtcag
    12301 acggatgtcg gaagtaggat cggtagtatt attcagaccg ttatatattt tattcagggc
    12361 gttcttcaga tagtcattgg cggcagagac tgtcataccg ctaaggttga cagggccgat
    12421 cttctgaatg ttgatagtac cttcaggaga gatttgctgg cggatcgtgt tctggctcgc
    12481 accccagata tcaatgatga cttcatcacc gggaccaaga cggtaattgg caggagtggc
    12541 aaggttgaca ctaggctcga acgtcaggtt gcgggtattg aagatgttac gtccgaagac
    12601 ctgatcacca cgggcaaggt cctgagtagt cggatgatcc tccagcatat cggaagtatt
    12661 cttcttagtc tcttcacgca ggcgggattc gttgatgtcc gtgcccgttg atttcgaggt
    12721 atttacattg ttctgctgct cgtatagctg cttcacacgc attgcctgtt ctttggttac
    12781 acccttacgg gctagttcgg aagcaagctg cttctgttcc ttgccttggc ggatgccgtc
    12841 ttttacatat tccagtacct gtgagtcact catggactga gccataagcg agccacttcc
    12901 cagcatcaaa caaaatagta gaatgctaaa aagtcgttgt attttcattg acaaataaaa
    12961 aagtttcagt tgatttcaca cagttcctgc atcccatgac agacggcaga taactgttgc
    13021 ttaagaagag aagggggaag aacatcgaga agagacagag aacgggtcaa aacagcctgt
    13081 tttctttctt cgtcttccgg attggcgtac atcgacacat tatatccctg aaggatggcc
    13141 aaacacaggg tagcatcctg ctccggtgtc tccccccgtt gagaatataa atcgttaatc
    13201 ttttcgtgga tggatcgttg taatgctgaa agatcatcca aatacacgca gcctgcactc
    13261 cccccaccag gaagcagcat acgtaccaaa cttaataaac cctctatatt ttcttgtaaa
    13321 ataatagcat ccatatccct tgccttaaac agccgccata atcggctcta cataaccgac
    13381 aggcatatca acacaggcgc atcccagcat attcaagcga acagcaatct tacttttacc
    13441 atccacattg accagttcgc caacaagacc cgtcaacgga cctttgatca cgcgaacctt
    13501 ttcgccacga gccaaaggag aactgttcat gcttatcgat tcttccgaat aatcaagcat
    13561 gaaacggaaa cgagccatct gctcgtcagg aattacagca ggactactct cgccgcgcat
    13621 caccatgtaa cggctgacag tagaaaaact caggacttcc atgcgttcct tagggtcaac
    13681 gtgtacgaag accatcatag gaagcaagac ggaggtgacc agcttgcgac ggtcgctcca
    13741 ttggtggaat tcctgttgaa cgggaacgaa attctcgata cccatcttgt ccagatgctc
    13801 ggaaaccttc ttttcatggt gcatccgaac caaagcaaca taccagcgtt ttgagtgtgc
    13861 tacgccttcc cctgtcccat taataggccc agcatttagt gatttctttt ttcttaaaat
    13921 catatttttt taccccatgt ttatccgtta cttcttaggt aacgaacaag catagggcaa
    13981 gcagaaaagg gaactttttt caacgaaaac atcagaagag gactggtatt caggaaataa
    14041 agcagaagtg aaggtgtttt tcatgaattg gaataaaaaa aagacataac acggatattg
    14101 tcattttccg cctgttatgc ctgcatttga ttcattttcc gaaattaatt tcatttttgt
    14161 ttgcgtattt tcataaatat gtccatcttt gcgccatgaa tcattccgtt acctaagaag
    14221 taacgcacac cgataaacac tgtatatcaa gcttctaaat cagatacact gacctactcc
    14281 gcaccgcttt acgtaagaca aattcatccg gttc
//
