LOCUS       gnlProkkaBGHIMFGF_4    14314 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BGHIMFGF_4.
ACCESSION   gnlProkkaBGHIMFGF_4
VERSION     gnlProkkaBGHIMFGF_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:02:35
            Original ID  :: gnl|Prokka|BGHIMFGF_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2969854
            Orig. end    :: 2984168
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14314
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9314]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9314
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14314
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14314
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             390..968
                     /locus_tag="ctg4_2138"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPRERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             979..1347
                     /locus_tag="ctg4_2139"
                     /transl_table=11
                     /translation="MDAVILQENIEGLLNLVRMLLPGGGSAGCVYLDDLSALQRSIHKQ
                     INDLYSQRGKTPEQDATLCLAILQGYNVSMYANPEDEDRKRSVLQRSLTLLDVLPPSLL
                     KQQLSAVCHGMQELCETN"
     CDS             1363..3774
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 30.3;
                     E-value: 2.7e-09)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_2140"
                     /sec_met_domain="Poly_export (E-value: 1e-15, bitscore:
                     55.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCSMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSQSTGTDINESRLREETKENTSDMLED
                     HPTTEDLAREDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKGALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDMDYSIYTMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVNEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMNGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTSLAYLRGAKLTRVASAGEKK
                     RMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVVFIP
                     KNTNTVTINGAVMVPNTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3789..4937
                     /locus_tag="ctg4_2141"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2142"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.4e-14, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2143"
                     /sec_met_domain="CTP_transf_like (E-value: 7.6e-11,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 7.8e-119, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 8.8e-61, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8183
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2144"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.1e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.6e-18, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8193..9314
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg4_2145_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2145"
                     /sec_met_domain="Aminotran_5 (E-value: 5.9e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8283..9290
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_2145_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg4_2145_Aminotran_5.1"
                     /locus_tag="ctg4_2145"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9311..9454
                     /locus_tag="ctg4_2146"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9657..10967
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_2147"
                     /sec_met_domain="Polysacc_synt (E-value: 4e-29, bitscore:
                     100.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGDRFYMYFFL"
     CDS             11096..12355
                     /locus_tag="ctg4_2148"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             12364..13113
                     /locus_tag="ctg4_2149"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             13113..14153
                     /locus_tag="ctg4_2150"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 accggatgaa tttgtcttac gttaagaggt gcggttctgg cctgtatgtg tgatttagaa
       61 tcctgatata cagtgtttat tggtgtgtgt tacttcttag gtaacggaat gattcatggc
      121 gcaaagatgg acatatttat gaaaatacgc aaacaaaaat gaaattaatt tcttaaaatg
      181 aatcaaaagt cggcataaca gacggaaaat gacaatatcc gtgttatgtc ttttttttat
      241 tccaatttat gaaaaacacc ttcacttctg ccttatttcc tgaataccag tcctcttccg
      301 atgttttcgt tgaaaaaagt tccctgtttc gcttgtcctt tgtttgtgag ttacctaaga
      361 agtaacggat aaacatgggg taaaaaaaca tgattttaag aaaaaagaaa tcactcaatg
      421 ctgggcctat taatgggaca ggggaaggcg tagcacactc aaaacgctgg tatgttgctt
      481 tggttcggat gcaccatgaa aagaaggttt ccgagcatct ggacaagatg ggtatcgaga
      541 atttcgttcc cgttcaacag gaattccacc aatggagcga ccgtcgcaag ctggtcacct
      601 ccgtcttgct tcctatgatg gtcttcgtac acgttgaccc tagggaacgc atggaagtcc
      661 tgagtttttc tactgtgagc cgttacatgg tgatgcgcgg cgagagtagt cctgccgtaa
      721 ttcctgacga gcagatggcc cgtttccgtt tcatgcttga ttattctgaa gaatcgatca
      781 gcatgaacag ttctcctttg gcccgtggcg aaaaggtccg cgtgattaaa ggccccctga
      841 cgggtcttgt tggcgaactg gttaatgtgg atggcaagag taagatcgcc gttcgcctga
      901 atatgctggg atgtgcctgt gtggatatgc ctgtcggtta tgtagagcct attatggcgg
      961 ctgtttaagg tgagggatat ggatgctgtt attttacagg aaaacataga gggtttatta
     1021 aatttggtac gcatgctgct tcctggtggg gggagtgcag gctgcgtgta tctggatgac
     1081 ctttccgcct tacaacgatc catccacaaa cagataaacg atttatattc acaacggggg
     1141 aagacaccgg agcaggatgc taccctgtgt ttggccatcc ttcagggata taatgtgtcg
     1201 atgtacgcca atccggaaga cgaggataga aaacggtctg tcttgcagcg ttctctgacc
     1261 ctccttgatg ttcttccccc ttctcttctt aaacaacagt tgtctgcggt ctgtcacggt
     1321 atgcaggaac tgtgtgaaac caactaactt ttttatttgt caatgaaaat acaacgactt
     1381 tttagcattc tacttttttg ttctatgctg ggaagtggct cgcttatggc ccagtccatg
     1441 agtgactcac aggtactgga atatgtaaag gacggcatcc ggcaaggcaa ggaacagaaa
     1501 cagcttgctt ccgagcttgc gcgtaaaggt gtgaccaagg aacaggctat gcgtgtgaag
     1561 cagctctatg agcagcagaa caatgtaaac acctcccaat ccacgggtac ggatatcaac
     1621 gagtcccgcc ttcgtgaaga gactaaggag aatacttccg acatgctgga ggatcatccg
     1681 actacggaag atttggcccg tgaggatcag gttttcgggc gcaacatctt caatacccgc
     1741 aacctgacgt tcgagcctag tgtcaacctt gccactcctg ccaattaccg tctgggtccc
     1801 ggtgatgaag tcatcatcga tatctggggt gccagccaga acacgatccg ccagcagatc
     1861 tctcctgaag gcaccatcaa tattcagaag atcgggcctg tcaaccttag cggtatgaca
     1921 gtctccgccg ccaacgacta tctgaagggc gccctgaata agatctataa cggtctgaac
     1981 aatactaccg accctacttc cgacatccgt ctgactttgg gtaatatccg tactattcag
     2041 atcaacgtga tgggagaggt cgtgcagccg ggtacctacg ccctttcttc cttctctacc
     2101 gtcttccacg cgctttaccg tgcaggcggc gtgagtgata tcggcagcct ccgaaacgtt
     2161 cagttggtac gcaacggaaa gaatatcgcc accatcgatg tttacgaatt tatcatgaaa
     2221 ggcaacacac aggatgacat ccgccttcag gaaggtgacg tggttatcgt ccccgcctac
     2281 gatgtcttgg taaagatcag cggcaaggta aaacgtccta tgcgtttcga aatgaagaaa
     2341 gacgagaacc ttgccacttt aatcaaatat gccggcggct ttgaagctga cgcctacacc
     2401 cgttcattac gtgttgtccg tcagaatggt gaggaatatg aggtcaacac agtcaaggat
     2461 atggactaca gcatctacac aatgcgtaac ggcgacgttg taacagccga agccatcctt
     2521 aaccgcttca caaacaaact ggaaatccgt ggcgctgtct atcgtcccgg catctaccag
     2581 ctcagcggta aactgaacac gatccgcgaa cttgtcaatg aagcccaggg tctgaccggt
     2641 gacgctttcc tgaatcgtgc cgtcctttat cgccagcgtg aggacctgac cagtgaagtt
     2701 gttcagatag atatcaagtc tatcatgaac ggtacttccc cgaaccttgc cctgatgaag
     2761 aatgacattc tctacatccc gagcattcac gatctggaag atcgtggcaa tgtcacagtt
     2821 cacggtgaag tcgcgcaccc cgattcctat ccctatgctg ataacatgac acttgaggat
     2881 ctgatcatcc aggccggtgg cttgaaagaa gccgcctcta ctgtccgcat tgatgtgtcg
     2941 agacgaatca agaatccccg tagtaccgcg gataatgata ctatcggtca gatgtatacc
     3001 ttctctttaa aggatggttt tgtcatcgac ggtcagcccg gttttatcct tcagccttat
     3061 gacgaagttt atgtccgtcg cagtcccggt tatcaggcgc aacagaatgt agtcattgat
     3121 ggtgaaatat tgtttggagg aaattatgcc atgaccaacc gtgaggaacg tctttccgat
     3181 ctggtgaata aagcgggtgg tcctaccagt cttgcctatc tccgtggtgc gaaattgacc
     3241 cgtgtggcaa gtgccggtga gaagaaacgt atgggtgatg tgattcgcct gatgagcagg
     3301 caattgggtg aagccatgat tgactctttg ggtattggtg ttgaggatac ctttacggta
     3361 ggcattgatc tggagaaggc tttgactaat cctaagggta gtgccgacct tgtcctacgt
     3421 gaaggtgatg tggtctttat acctaagaat actaatactg taactatcaa tggtgctgtt
     3481 atggtcccca atacggtttc ttatatgaag ggaaaggatg tggattatta cctgaatcag
     3541 gccggtggct attctgataa tgcaaggaag agtaagaagt tcattgttta catgaatggt
     3601 caggtgacga aggttaaggg tagtggtaag aaacagattg agccggggtg tgagattatt
     3661 gtgcctggta aggctaagaa gaaagggaac atagctaata ttttaggtta tgctacttcc
     3721 ttcagttctt tgggaatgat gattgcttct attgctaatc ttataaagaa ataatagaat
     3781 ttacttttat gtcagaacaa cgacaggata aaaacttgct ctctgaacca cacaagacag
     3841 aaagtgatga gatagaaatt gatttggtcg atatctttcg caagattatt gctattcgta
     3901 aaaaattata caaagccgtt ggaattggtt ttattattgg aataattgta gcggtaagta
     3961 tccctaaaca gtatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggga
     4021 gtaatggttt agccggactt gctgcctcgt ttttaggaga tggggctcta ataggggaaa
     4081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     4141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgttttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttacatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtgg cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaatagct ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccctgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tttcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacag atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agataatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaaag aaatattgga
     7021 actgattcca ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgtccg ggggagcgga tataagcata cttatactgt ttgtacaaaa gttgaaattg
     8041 aagaagcaat gaagcagctt ccaaagttat gtggtcctgt tttgttggaa ataaaggtta
     8101 aaatagattc tcgggagaat ttgggacgtc ccacgactac tcctatagag aataaggagc
     8161 attttatgga ttttttaaaa taaatatatt cgatgaaaat agaaagaaaa atattattaa
     8221 atcctgggcc tgccactact actgacagtg taaaaatggc acaagttgtt ccggatattt
     8281 gtcctcgcga gaaagaattc gcaggtatga tgaaacaact tcgggacgat ttggtcagag
     8341 ttgctcatgg gaatttggaa aaacataccg ctgtattatt ttgtggctca ggaaccatca
     8401 atattgatat atgtctaaat tctcttcttc ctgaagacaa aagggtgctt atagtgaata
     8461 atggggcata tagtacccgt gctgtagaag tgtgtcaata ttatggtttg cctcatatta
     8521 atttggaatt ttccgtttac gaacgtcctg atttatcggt ggtggaaaat gtgttgcaag
     8581 aaaatcctga tatagctatg gtttatacta ctcatcacga gacgggtaca ggaattctga
     8641 accctattcg cgagatgggc gctatagctc ataaatatca ggctaaattt gtcgtcgata
     8701 ctacttcttc tttgggcatg attccttttg atatagagaa agataatgtg gatttttgta
     8761 tggcatctgc tcaaaaagga cttcaagcga tgacaggtct ttcttttatt ataggcaatg
     8821 aggaacagat taagttttca aaaaaatatc ccaagcgttc ttactattgt aatctttatt
     8881 tgcagtatga gaattttgag agaacaggtg aaatgcattt tactccaccg gtacaaacta
     8941 tttacgccac tcgtcaggca ttaaatgaat attttgaagt gggtgaagaa gctaagtttg
     9001 cccgtcacaa aagagttttt gaggctattc attcaggtat aaatgaaatt ggtcttaaaa
     9061 gtgtaataaa gcgtgaatgg cagtcaggac tggttgtctc agttcaatac ccagaagatc
     9121 ccaactggga ttttgagaaa atacatgatt attgttatga gcgtggattt acgatttatc
     9181 caggtaagat atcaactgag gatactttta gaatctgtgc tttaggagag atagaagtag
     9241 atgatattga gaacttcttt aaagtactaa aagctgcatt aaatcattat aacgtcacat
     9301 taccgatgtc atgattgcag aaatattatt gaagattcgt catttttatt tttcccttcg
     9361 tggtatacac ttccatccgg aaagtgttat ttctggagtg cctattcgta gctttcgctt
     9421 agtaggcaaa tatggcaata ttaatttgag gtgatgcatt aggagttctt tattcttata
     9481 aaaaggcatc ggtagttata ggagataatg tttgtgtagg gtaatttgct tttagtggga
     9541 gagaccatat tagaattgcg gtaaggggcg aagaagataa taaccaatta gtgagaatat
     9601 tggaaaaata taattgatat cggtaaatgt agttgttttt atactgtatt taagtaatgg
     9661 aaaatctaaa gcagaaaact gtatcaggaa taatgtggag cgctatagaa cgtttctctt
     9721 tacaaggagt acagtttata attcaaataa tattagctcg tttgttacta ccatcggatt
     9781 atggtatgat cgggatgtta gctatttttc ttcaagtcgc tcaagtattt atagatagcg
     9841 gttttacaaa tgctttaatc cagaaaaaag atagaactga agaggatttt gccactgtct
     9901 tttattttaa tattcttgtc gcagtattat tctatggtat attgtttttt tcggcttctt
     9961 tgattgcaga cttttataat atgccgactt tagttcttgt aattcgtttt atagcattgt
    10021 cgttgataat aaatgcttta tcggctattc acagaacgaa attaattatt tctgtaaact
    10081 ttaaaactca atctaaaatt tcattaggtg cagcttttat atcaggcgtg attggaatat
    10141 ggatggctta tgtcggttgc ggggtttggg ctttagtttg gcaaactctc ttaaatagta
    10201 taattttgac aattttgttt tactgtttag ttcattggaa acctttacat actttctcca
    10261 aaagttcttt tgaaagatta ttcaatttcg gatctaaatt attgatctca agtcttatca
    10321 atacagtata tcgtaatctg tataccattg taataggaaa aaagttttct gttgtagagc
    10381 ttggttacta tacaagagca gaacaatttg ctatttttcc ttccaataat ttaaatgctt
    10441 tagtttctag agtagcgtat cctattttaa gttccattca agatgatgat aaatgtttaa
    10501 caaacgcata tcgaaattat atcagattat cctcatatat aatttttcct ttaatggtag
    10561 gtttacttgt tttggctaat cctattatta gtctattgtt aacagataaa tggtctgggg
    10621 ttgttattct tttacagata ttatgtttgg attggatgtt tgatcatttg agccaaatta
    10681 atttgaattt attatgggtt aaaggaagat ctgatctgtc gttacgtctt gaaataataa
    10741 aaaagacgat tgctatattc attctttttg tgtcaattcc atttgggctt gaggtgatgt
    10801 gttggggtag agttatttac tctctgatag cgacatattt gaatacatat tatactaatt
    10861 ctcttattga tttgacctta aagttgcaag ttaaagatgt atttccaagt ttaatactct
    10921 ctttcataat ggggggggat cgtttttata tgtatttctt tctttgaaac tgatatagta
    10981 aaaattgtga ttggatgtat tactgggatg tccttctata ttttactttc ttttcttttt
    11041 aagctagatt cttttttttg tattttaaca ttgatcatta aaactaaaaa catagatgaa
    11101 aatattaaaa aagatttttc aagtaatagt aaagataatt aaccattgtg tgccagttga
    11161 tagtagatca ttgtatttta ttcctcatcc taattgtaga acagataaat atgatattat
    11221 aaattattcg tcagataatg ttctcgttct gttaaattat ttgctaaaaa aagatagtgc
    11281 tgaatattat aaaatatatg ttgaaattta tgattcttct cgtatttcag aatatcaaga
    11341 atatatttat ggcataaatc ctaatattag gtgtactttt ttatgtgcat gtgttggacg
    11401 ttttttcttt aataaagtat cttttaagga tatgttgtat gccttttttt gtttttgtag
    11461 agcaagtaaa tgttttacag ctacttttta ttatgatttt tcatttaaaa aacgctctca
    11521 acagattatt tgtttggggt attatactcc attcaaagat gattatcata tgggagatca
    11581 ttcttatgat aaatttcgta atacaacatg taactcattt gattactcta ttgctacttc
    11641 ttgtttaagt gctagaataa tttcaataga ttgtggaatc tcatatgata aattcaaagt
    11701 cttaggattt cccagaaatg atttgttgat atcgaaaaat aattgcaatg ttattaaaag
    11761 agaaatttcg aaatttgcgg gatatgatgt aactaaatat atagtttata ctccaacttt
    11821 tcgtgattat gagactgtta ctgaaggtaa tttgcgttca atactcggat atgttgattg
    11881 tgatttgttg aagttatcga aaatactatt gaagtttaat gcggctttaa ttcttaaatt
    11941 acatcctttg cagaataaaa cagtcttaaa aaaagattta cccaaaggta tacttgtttt
    12001 tgaacaaaca tataaatatg gattgtatga tcttttgtca ttttcagatg gaatgattac
    12061 tgattatact tctacctatt ttgatttttt attggtaaat aagccagtca tatttaattt
    12121 ctacgatatt gaagaatatc gtagagtaag aggtttctca tttgagccaa tagaattttt
    12181 ttgtgcaggt gatattgttt acaattataa tgaattgata gatgctgtga tgggacttct
    12241 ggctgggaaa gatattcatg ctgaacatcg acgtcatatt tctttattga tgaatcaatt
    12301 tcaagatgat aattcaacaa agagaatatg tgacatattt ttaaatgaaa tataataaat
    12361 aaaatgaatt atgcatttgt ggtgcaggca cgtttaggtt ctacacgttt gcctggaaaa
    12421 atattgaaac ctttctatgg taatcaatcg attcttgact taatggttca taagctttct
    12481 gctatatcga atattccagt aattattgct acaacaaatt ctgttatcaa tgaacctatt
    12541 gaaaagaagg cacttgcatt aggggtaaag tgcttcagag gtgaggagaa tgatgtttta
    12601 aaacgattca ttgatgttgc tgaatatttt gatatacagg gtatattccg aatatgttct
    12661 gataatccat ttttagatgt acatgcggca aggcaattgg tcgaaatagc aatgaaatct
    12721 tgtaacgatt atataagttt tgatattgat ggtactccat caattaaaac tcatttcggt
    12781 ttttggggag aatttgtaac gcttgatgcg ctgaagcgag ttataggatt tactgatgat
    12841 ttattgtatc gtgaacatgt tactaattat atatatagtc atcctgaact ttttaatatt
    12901 caatggattt caggatctcc agtcgtgtca aaacatcata atattcgact cacgattgat
    12961 acgttagaag atttttctgt agcacagaga atatataggg atttacaaga aaaaagagtg
    13021 gaaatatcga tagaagtgat tgtagactat gttcgaagac atgcagaata cattcaactg
    13081 atgaaacaac aaataaaaaa aaattctaaa taatgaagaa tacttatatt attggtgaaa
    13141 tagggcagaa tcataatggt tctgttgact tggctaagtt gattattgaa ttaatctcac
    13201 gacctgtaca tgaggatgtt tttggtatgg atttcatgcc aatgaatgct gttaaaatga
    13261 ctaaaagaga tttatcagaa gaattggctg tttctcaaat gaatcaaata tatgacaatc
    13321 ctaattcttt tgggcgtact tatggtgaac atcgtgcttt tcttgagctt gatgatcaag
    13381 cgcattttga gatttataaa tatgctaagt cattaggatt agattttatc gagacgttat
    13441 gtgccaaagg atgtctgtct ttgcttaaac tgttcacacc ggataggcta aaagttgcta
    13501 gtcgtgattt gactaactta ccattgcttg aagcattagc agaaactcat attcctatta
    13561 tattatcgac aggaatggct ggtcaaagag aacttgacaa tgcattagat gtgataacga
    13621 gatatcatag taatatagct attctacatt gtgtatctca gtatccaact catccaaata
    13681 atttgaatct acgtacaata acatatttga agaagcatta caataagttt gagataggtt
    13741 tttctgatca tacaataggt atttctgctg ctacagctgc tgtagcgatg ggagcggaaa
    13801 ttatagaaaa gcatgtaaca attgatcggc atatgaaagg aacagaccag cttggctctt
    13861 taggtccaga tggggttaat cgtatgattc gagatattcg catagcagag tgttggcttg
    13921 gtactgaaga tctttatata gaaaaagggg tggagaagtc taagataaaa cttgaacgtt
    13981 ctattgccac tcgaaaatat attccagcag gtagtattat tcaagagtcg gacattcatt
    14041 tactgagtcc tggtgatggt tataaatgga tagataaaaa aaatgtaatt ggtcattttg
    14101 ctaaacaaga tatatcagcg aatgaaataa tatatcctga ttttattgaa tagatatatt
    14161 cctactgcaa cttgtattac ggtatagagt actgcctgct ataagctaag tagtgattaa
    14221 taaataaggg taaaatacta aaaaaatgaa agagataaag cttatactta cagatattga
    14281 tggcgtttgg actgatggcg gaatgtttta tgat
//
