LOCUS       gnlProkkaEFGLMPBB_4    14313 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EFGLMPBB_4.
ACCESSION   gnlProkkaEFGLMPBB_4
VERSION     gnlProkkaEFGLMPBB_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:02:55
            Original ID  :: gnl|Prokka|EFGLMPBB_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1826045
            Orig. end    :: 1840358
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14313
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9313]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9313
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14313
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14313
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(234..1208)
                     /locus_tag="ctg4_1545"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKM"
     CDS             complement(1288..1956)
                     /locus_tag="ctg4_1546"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKEWKYR
                     "
     CDS             complement(2102..2266)
                     /locus_tag="ctg4_1547"
                     /transl_table=11
                     /translation="MITDYTSTYFDFLLVNKPVIFNFYDIEEYRRVRGFSFEPIEFFVQ
                     VILFTIIMN"
     CDS             complement(2263..3222)
                     /locus_tag="ctg4_1548"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKIYPKVYLFLNKHINMDCMIFCHFQME"
     CDS             complement(3340..3519)
                     /locus_tag="ctg4_1549"
                     /transl_table=11
                     /translation="MCWGRVIYSLIATYLNTYYTNSLIDLTLKLQVKDVFPSLILSFIM
                     GGSFLYVFLSLKLI"
     CDS             complement(3519..4658)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_1550"
                     /sec_met_domain="Polysacc_synt (E-value: 1.1e-29, bitscore:
                     100.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKRRLLYSFFLCQFHLGLR"
     CDS             complement(4861..5004)
                     /locus_tag="ctg4_1551"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg4_1552_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_1552"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_1552_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg4_1552_Aminotran_5.1"
                     /locus_tag="ctg4_1552"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_1553"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-18, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..7671)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 96.7;
                     E-value: 2.1e-29)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_1554"
                     /sec_met_domain="phosphonates (E-value: 1.8e-50, bitscore:
                     168.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.2e-28, bitscore:
                     95.7, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKNKSGEDI
                     KEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAMMNVAKI
                     ILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(7668..8573)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 77;
                     E-value: 2.1e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_1555"
                     /sec_met_domain="CTP_transf_like (E-value: 1.8e-11,
                     bitscore: 41.4, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-48, bitscore:
                     159.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 8.6e-24, bitscore:
                     81.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKRIHCLVQMLFKLKIQ
                     SKVSVIRSKQERHLRLLMIL"
     CDS             complement(8594..9313)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_1556"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.5e-14, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9377..10525)
                     /locus_tag="ctg4_1557"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10536..12947)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_1558"
                     /sec_met_domain="Poly_export (E-value: 1.7e-16, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKEENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(12965..13279)
                     /locus_tag="ctg4_1559"
                     /transl_table=11
                     /translation="MLLPGGGSAGCVYLDDLSALQRSIHEKINDLYSQRGETPEQDATL
                     CLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGMQELCEIN
                     "
     CDS             complement(13344..13922)
                     /locus_tag="ctg4_1560"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 ctgtttgatc ataaaacatt ccgccatcag tccaaacgcc atcaatatct gtaagtataa
       61 gctttatctc tttcattttt ttagtatttt acccttattt attaatcact acttagctta
      121 tagcaggcag tactctatac cgtaatacaa gttgcagtag gaatatatct attcaataaa
      181 atcaggatat attatttcat tcgctgatat atcttgttta gcaaaatgac caattacatt
      241 tttttatcta tccatttata accatcacca ggactcagta aatgaatgtc cgactcttga
      301 ataatactac ctgctggaat atattttcga gtggcaatag aacgttcaag ttttatctta
      361 gacttctcca cccctttttc tatataaaga tcttcagtac caagccaaca ctctgctatg
      421 cgaatatctc gaatcatacg attaacccca tctggaccta aagagccaag ctggtctgtt
      481 cctttcatat gccgatcaat tgttacatgc ttttctataa tttccgctcc catcgctaca
      541 gcagctgtag cagcagaaat acctattgta tgatcagaaa aacctatctc aaacttattg
      601 taatgcttct tcaaatatgt tattgtacgt agattcaaat tatttggatg agttggatac
      661 tgagatacac aatgtagaat agctatatta ctatgatatc tcgttatcac atctaatgca
      721 ttgtcaagtt ctctttgacc agccattcct gtcgataata taataggaat atgagtttct
      781 gctaatgctt caagcaatgg taagttagtc aaatcacgac tagcaacttt tagcctatcc
      841 ggtgtgaaca gtttaagcaa agacagacat cctttggcac ataacgtctc gataaaatct
      901 aatcctaatg acttagcata tttataaatc tcaaaatgcg cttgatcatc aagctcaaga
      961 aaagcacgat gttcaccata agtacgccca aaagaattag gattgtcata tatttgattc
     1021 atttgagaaa cagccaattc ttctgataaa tctcttttag tcattttaac agcattcatt
     1081 ggcatgaaat ccataccaaa aacatcctca tgtacaggtc gtgagattaa ttcaataatc
     1141 aacttagcca agtcaacaga accattatga ttctgcccta tttcaccaat aatataagta
     1201 ttcttcatta tttagaattt ttttttattt gttgtttcat cagttgaatg tattctgcat
     1261 gtcttcgaac atagtctaca atcacttcta tcgatatttc cactcttttt cttgtaaatc
     1321 cctatatatt ctctgtgcta cagaaaaatc ttctaacgta tcaatcgtga gtcgaatatt
     1381 atgatgtttt gacacgactg gagatcctga aatccattga atattaaaaa gttcaggatg
     1441 actatatata taattagtaa catgttcacg atacaataaa tcatcagtaa atcctataac
     1501 tcgcttcagc gcatcaagcg ttacaaattc tccccaaaaa ccgaaatgag ttttaattga
     1561 tggagtacca tcaatatcaa aacttatata atcgttacaa gatttcattg ctatttcgac
     1621 caattgcctt gccgcatgta catctaaaaa tggattatca gaacatattc ggaatatacc
     1681 ctgtatatca aaatattcag caacatcaat gaatcgtttt aaaacatcat tctcctcacc
     1741 tctgaagcac tttaccccta atgcaagtgc cttcttttca ataggttcat tgataacaga
     1801 atttgttgta gcaataatta ctggaatatt cgatatagca gaaagcttat gaaccattaa
     1861 gtcaagaatc gattgattac catagaaagg tttcaatatt tttccaggca aacgtgtaga
     1921 acctaaacgt gcctgcacca caaatgcata attcatttta tttattatat ttcatttaaa
     1981 aatatgtcac atattctctt tgttgaatta tcatcttgaa attgattcat caataaagaa
     2041 atatgacgtc gatgttcagc atgaatatct ttcccagcca gaagtcccat cacagcatct
     2101 atcaattcat tataattgta aacaatatca cctgcacaaa aaattctatt ggctcaaatg
     2161 agaaacctct tactctacga tattcttcaa tatcgtagaa attaaatatg actggcttat
     2221 ttaccaataa aaaatcaaaa taggtagaag tataatcagt aatcattcca tctgaaaatg
     2281 acaaaagatc atacaatcca tatttatatg tttgttcaaa aacaagtata cctttgggta
     2341 aatctttttt aagactgttt tattctgcaa aggatgtaat ttaagaatta aagccgcatt
     2401 aaacttcaat agtattttcg ataacttcaa caaatcacaa tcaacatatc cgagtattga
     2461 acgcaaatta ccttcagtaa cagtctcata atcacgaaaa gttggagtat aaactatata
     2521 tttagttaca tcatatcccg caaatttcga aatttctctt ttaataacat tgcaattatt
     2581 tttcgatatc aacaaatcat ttctgggaaa tcctaagact ttgaatttat catatgagat
     2641 tccacaatct attgaaatta ttctagcact taaacaagaa gtagcaatag agtaatcaaa
     2701 tgagttacat gttgtattac gaaatttatc ataagaatga tctcccatat gataatcatc
     2761 tttgaatgga gtataatacc ccaaacaaat aatctgttga gagcgttttt taaatgaaaa
     2821 atcataataa aaagtagctg taaaacattt acttgctcta caaaaacaaa aaaaggcata
     2881 caacatatcc ttaaaagata ctttattaaa gaaaaaacgt ccaacacatg cacataaaaa
     2941 agtacaccta atattaggat ttatgccata aatatattct tgatattctg aaatacgaga
     3001 agaatcataa atttcaacat atattttata atattcagca ctatcttttt ttagcaaata
     3061 atttaacaga acgagaacat tatctgacga ataatttata atatcatatt tatctgttct
     3121 acaattagga tgaggaataa aatacaatga tctactatca actggcacac aatggttaat
     3181 tatctttact attacttgaa aaatcttttt taatattttc atctatgttt ttagttttaa
     3241 tgatcaatgt taaaatacaa aaaaaggaat ctagcttaaa aagaaaagaa agtaaaatat
     3301 agaaggacat cccagtaata catccaatca caatttttac tatatcagtt tcaaagaaag
     3361 aaatacatat aaaaacgatc cccccattat gaaagagagt attaaacttg gaaatacatc
     3421 tttaacttgc aactttaagg tcaaatcaat aagagaatta gtataatatg tattcaaata
     3481 tgtcgctatc agagagtaaa taactctacc ccaacacatc acctcaagcc caaatggaat
     3541 tgacacaaaa agaatgaata tagcaatcgt ctttttatta tttcaagacg taacgacaga
     3601 tcagatcttc ctttaaccca taataaattc aaattaattt ggctcaaatg atcaaacatc
     3661 caatccaaac ataatatctg taaaagaata acaaccccag accatttatc tgttaacaat
     3721 agactaataa taggattagc caaaacaagt aaacctacca ttaaaggaaa aattatatat
     3781 gaggataatc tgatataatt tcgatatgcg tttgttaaac atttatcatc atcttgaatg
     3841 gaacttaaaa taggatacgc tactctagaa actaaagcat ttaaattatt ggaaggaaaa
     3901 atagcaaatt gttctgctct tgtatagtaa ccaagctcta caacagaaaa cttttttcct
     3961 attacaatgg tatacagatt acgatatact gtattgataa gacttgagat caataattta
     4021 gatccgaaat tgaataatct ttcaaaagaa cttttggaga aagtatgtaa aggtttccaa
     4081 tgaactaaac agtaaaacaa aattgtcaaa attatactat ttaagagagt ttgccaaact
     4141 aaagcccaaa ccccgcaacc gacataagcc atccatattc caatcacgcc tgatataaaa
     4201 gctgcaccta atgaaatttt agattgagtt ttaaagttta cagaaataat taatttcgtt
     4261 ctgtgaatag ccgataaagc atttattatc aacgacaatg ctataaaacg aattacaaga
     4321 actaaagtcg gcatattata aaagtctgca atcaaagaag ccgaaaaaaa caatatacca
     4381 tagaataata ctgcgacaag aatattaaaa taaaagacag tggcaaaatc ctcttcagtt
     4441 ctatcttttt tctggattaa agcatttgta aaaccgctat ctataaatac ttgagcgact
     4501 tgaagaaaaa tagctaacat cccgatcata ccataatccg atggtagtaa caaacgagct
     4561 aatattattt gaattataaa ctgtactcct tgtaaagaga aacgttctat agcgctccac
     4621 attattcctg atacagtttt ctgctttaga ttttccatta cttaaataca gtataaaaac
     4681 aactacattt accgatatca attatatttt tccaatattc tcactaattg gttattatct
     4741 tcttcgcccc ttaccgcaat tctaatatgg tctctcccac taaaagcaaa ttaccctaca
     4801 caaacattat ctcctataac taccgatgcc tttttataag aataaagaac tcctaatgca
     4861 tcacctcaaa ttaatattgc catatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc acccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga ttttcttgca acacattttc caccaccgat
     5761 aaatcaggac gttcgtaaac ggaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgggt actatatgcc ccattattca ctataagcac ccttttgtct
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagcggtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct attttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccgaactctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttttttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 atattcctct ttttatttag tacctggaat cagttccaat atttctttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt atctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc ctgctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatctgtac caaacaatga attcttttta atccaacttt atcttcaatt
     7801 attatagctg aaattccatg acgttctaaa gtgcgtactg taaatacgaa atgttcaatt
     7861 ttaccacctg tatctccatc aaaaataata ggtttagtag tacactccag aatattattc
     7921 aaatcttgca atcgggtagt taaatcaacc gcctcaatat caggtttacc tttactggtt
     7981 gaatccgtaa ggctactaga ccacattccg tcaaatactt ccctcttatc cccttttaat
     8041 atttcctgat tttcaattat caagccacat agtccatcat gagcttccaa aatacgaact
     8101 acgggtttgg catttatcaa acgacgaagt gattttaaac gtacatcagg ggttgtacct
     8161 atagccttaa tatctttatc caaagaagat gaattaattc ccaaagtata tggaatttcg
     8221 ataacctttc ctccctgttc attcatcact tcaaatacgc gcacacgttc ttcacgtaaa
     8281 ggcccggttt tccagtcgtc accatgaatt atatagtcag gtttaatgcg tttgagattc
     8341 tcaacatagc tccattcttc ttgaggaaca actttacata cgcctttaat attctgaact
     8401 acctcttttc gttgttcata ggtcagataa ggaaggcgtt tatgctccgc aatagcttta
     8461 tctgtaagaa gaccaattat aacatcaccg tatttagtag cctcattaat aatgcggata
     8521 agtcctggat gcataatatc cgcagtcatc ccaatataaa ctgtcttact cataatttga
     8581 tatattattt taattaacaa tacggaacaa tatatttctc tgcatattcc aaatctgata
     8641 tgtcatcgat ttcataccat ttcagccctt ctactttatg cacataaaca ggagattgag
     8701 aacaagatat tcgtagtaat tcatactcat atcccaaatt gggttgttca tcaacaatac
     8761 tcgcataatc agcacacatt attttgtaaa aggaaccgga tagtttatgg atgccgacca
     8821 attcgccttt agcgtttagt ttattcttat tgacagaaca tgaagaaagg cgaaaattat
     8881 catcatgttc cacataatac tgatcttgaa actttgtcac tggagttatt agcattgcat
     8941 ctgccgcagg acactccaat aagctcatta ttgcttgttt ctcaaaaatc aaatctgact
     9001 ctaacaataa aaaatcatca ttgcccagaa tctcccgcgt attatataaa gtatacatac
     9061 tatttgtttc agcataacga ggactaaaac aggtttcaag cataggatag tctgtcttca
     9121 attcttcata aacttcttgt ttatatcctg taccgattac aattcgctca atgtcacatg
     9181 ataacaaagt atcaatagaa cgaactatca ttggaatacc tcccactttg acgaaccctt
     9241 taggtatcaa ttctgtatat tggccaaaac gggttcccat gcccgcagcc attatcatag
     9301 ctgtacgtat cattcgttta ataatatagt aagtgaattt aattgatgta agaatgttgt
     9361 aaacgacgtt ttagcatcat ttatcctgtt ctatctcctt atttttcagt tcttttctca
     9421 agctagccag cagacttttg ccaaaaaaca cccacacgag agtaccagat acggacagga
     9481 acacaaataa taaaatataa attttgagtc ccatacctga aggtttcaaa ggtacaacgg
     9541 caggctcaac tactgcaaag actggctttt cctcctgtac tttggctctg gatacctgca
     9601 actgattagc aacctgacta tatatctgat aagccaaact catgtcgttc tgtaaacgct
     9661 cctgctcagc acgtacactt tgaagaacca cattatcatg ggcgtctaca taatccgcat
     9721 attttctttg agcagcataa tattcctgct gacgttcttt aaacaaccgt tccaaatacg
     9781 cacagtcttc ttttactttt gaagttcgat acccaataat atattcctgt aatttatgaa
     9841 cgacagaatc tgctataacc gcagtgatct gcggattttg taaggtgacc gtaatgctcg
     9901 ttatggcggt tttcttatca atggatgcac taatcttctt tttaagaaaa ttaatcttct
     9961 catttacttc tttcgtcaat tcgatagttc cttgccgccc tccactggca ggaaccgtat
    10021 cttctccgaa taatgattta actcctccta ttactatgcc cggaaaacct ataagataat
    10081 cccaccaagg agatgactct tcatcgagat aagaccccaa agtcatttta tcatcctttt
    10141 tagaaacgga gacttccatt tctaaaagtt ccaataaaaa aggagttgaa gaaacaatat
    10201 ctgctgaaag agaagcgttc aaggcatctg tgctttcccc tattagagcc ccatctccca
    10261 aaaacgaggc agcaagtccg gctaaaccat tacttccctt cgcattaccc atttcaggag
    10321 aaagggtaac ctttactgta tattgcttgg gaatgctcaa tgccaccact atagcaatta
    10381 ttactcccac tccagcagct ttgcatagta ctccacgaac agtaataatc ttataaaaaa
    10441 tagccatcaa gtctatttcc atttcatcat ctttcctttt atccacttca gaaaacggtt
    10501 cttgataaga ttgcttttca atcataatag gtcatttatt tctttatcaa attagcaata
    10561 gaagcaatca tcattcccaa agaactgaag gaagtagcat aacctaaaat attagctatg
    10621 ttccctttct tcttagcctt accaggcaca ataatctcac accccggctc aatctgtttc
    10681 ttaccactac ccttaacctt cgtcacctga ccattcatgt aaacaatgaa cttcttactc
    10741 ttccttgcat tatcagaaca gccaccggcc tgattcaggt aataatccac attctttccc
    10801 ttcatataag aaaccgtatt cggaaccatg acagcaccat tgatagttac agtattagta
    10861 ttcttaggta tggagatcac atcaccttca cgtaagacaa gatcggcatt acttttagga
    10921 ttgctcaagg ctttttccaa atctattcca accgtaaaag tatcttcaac acgaataccc
    10981 aaagagtcaa tcatggcttc gcccaattgc ctgctcataa ggcgaattac atcacccata
    11041 cgtttctttt cactagcgtt agccacacgg gtcagtttcg caccacgcag ataggcataa
    11101 ttggtcggac caccggcttt attcactaaa tcggaaagac gttcctcacg gctggtcatg
    11161 gcgtaatttc ctccgaaaag gatttcacct tcaatggcta cattctgttg tgcctgatag
    11221 cccggactgc gacggacata aacctgatca taaggctcaa ggataaaacc gggctgacca
    11281 tctattacaa aaccatcctt taaagagaag gtatacatct gaccaatcgt atcattatcc
    11341 gcagtactac gaggattctt gattcgtctc gatatatcaa tacggacagt agaggcggct
    11401 tctttcaagc caccggcctg aatgatcaga tcctcaagtg tcatgttatc cgcataagga
    11461 taggaatcag ggtgggcaac ctcaccgtga actgtgacat taccccggtc ttccaggtca
    11521 tggatacttg gaatgtagag gatgtcattc ttcattaggg caaggtttgg ggaagtgccg
    11581 tccatgatag acttaatgtc tatctgaaca acttcactgg tcaggtcttc acgctggcga
    11641 tagaggacgg cacgattcag gaaagcgtca ccggtcagac cctgagcttc atggacaagt
    11701 tcgcggatcg tgttcagttt accgctgagc tggtagatac cgggacgata gacagcgcca
    11761 cggatttcca gtttgtttgt gaagcggtta aggatggctt cggcggttac tacgtcaccg
    11821 ttacgcattt tataaatgtt gtaatctata tctttgactg tgttgacttc gtattcctca
    11881 ccattctgac ggacaacacg taatgaacgg gtgtaggcat cggcttcaaa gccgccggca
    11941 tatttgatta aagtggcaag gttctcttct ttcttcattt caaaacgcat aggacgtttt
    12001 accttgccgc tgatctttac caatacatca taagcgggaa caatcacgac gtcaccttcc
    12061 tgaaggcgga tgtcatcctg tgtgttgcct ttcatgataa attcgtagac gtcgatggtg
    12121 gcaatattct ttccgttgcg taccaactga acgtttcgga ggctaccgat atcactcaca
    12181 ccgcctgcac gataaagcgc atggaagacg gtagagaagg aagaaagggc gtaggtaccg
    12241 ggctgtacga cttctcccat cacattaatc tgaatagtac ggatattacc taacgtcaga
    12301 cggatgtcgg aagttggatc ggtcgtgttg ttcagaccgt tatatatttt attcagggcg
    12361 ttcttcagat agtcattggc ggcagagact gtcataccgc taaggttgac agggccgatc
    12421 ttctgaatgt tgatagtacc ttcaggagag atttgctggc ggatcgtgtt ctggctcgca
    12481 ccccagatat caatgatgac ttcatcaccg ggaccaagac ggtaattggc aggagtggca
    12541 aggttgacac taggctcgaa cgtcaggttg cgggtattga agatgttacg tccgaagacc
    12601 tgatcaccac gggcaaggtc ctgagtagtc ggatgatcct ccagcatatc ggaagtattc
    12661 ttcttagtct cttcacgcag gcgggattcg ttgatgtccg tgcccgttga tttcgaggta
    12721 tttacattgt tctgctgctc gtatagctgc ttcacacgca ttgcctgttc tttggttaca
    12781 cccttacggg ctagttcgga agcaagctgc ttctgttcct tgccttggcg gatgccgtct
    12841 tttacatatt ccagtacctg tgagtcactc atggactgag ccataagcga gccacttccc
    12901 agcatcaaac agaagagtag aatgctaaaa agtcgttgta ttttcattga caaataaaaa
    12961 agtttcagtt gatttcacac agttcctgca tcccatgaca gacggcagat aactgttgct
    13021 taagaagaga agggggaaga acatcgagaa gagacagaga acgggtcaaa acagcctgtt
    13081 ttctttcttc gtcttccgga ttggcgtaca tcgacacatt atatccctga aggatggcca
    13141 aacacagggt agcatcctgc tccggtgtct ccccccgttg agaatataaa tcgttaatct
    13201 tttcgtggat ggatcgttgt aatgctgaaa gatcatccaa atacacgcag cctgcactcc
    13261 ccccaccagg aagcagcata cgtaccaaac ttaataaacc ctctatattt tcttgtaaaa
    13321 taatagcatc catatccctt gccttaaaca gccgccataa tcggctctac ataaccgaca
    13381 ggcatatcaa cacaggcgca tcccagcata ttcaagcgaa cagcaatctt acttttacca
    13441 tccacattga ccagttcgcc aacaagaccc gtcaacggac ctttgatcac gcgaaccttt
    13501 tcgccacgag ccaaaggaga actgttcatg cttatcgatt cttccgaata atcaagcatg
    13561 aaacggaaac gagccatctg ctcgtcagga attacagcag gactactctc gccgcgcatc
    13621 accatgtaac ggctgacagt agaaaaactc aggacttcca tgcgttcctt agggtcaacg
    13681 tgtacgaaga ccatcatagg aagcaagacg gaggtgacca gcttgcgacg gtcgctccat
    13741 tggtggaatt cctgttgaac gggaacgaaa ttctcgatac ccatcttgtc cagatgctcg
    13801 gaaaccttct tttcatggtg catccgaacc aaagcaacat accagcgttt tgagtgtgct
    13861 acgccttccc ctgtcccatt aataggccca gcatttagtg atttcttttt tcttaaaatc
    13921 atattttttt accccatgtt tatccgttac ttcttaggta acgaacaagc atagggcaag
    13981 cagaaaaggg aacttttttc aacgaaaaca tcagaagagg actggtattc aggaaataaa
    14041 gcagaagtga aggtgttttt catgaattgg aataaaaaaa agacataaca cggatattgt
    14101 cattttccgc ctgttatgcc tgcatttgat tcattttccg aaattaattt catttttgtt
    14161 tgcgtatttt cataaatatg tccatctttg cgccatgaat cattccgtta cctaagaagt
    14221 aacgcacacc gataaacact gtatatcaag cttctaaatc agatacactg acctactccg
    14281 caccgcttta cgtaagacaa attcatccgg ttc
//
