LOCUS       gnlProkkaMILKMIMF_13   14317 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MILKMIMF_13.
ACCESSION   gnlProkkaMILKMIMF_13
VERSION     gnlProkkaMILKMIMF_13
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 09:35:06
            Original ID  :: gnl|Prokka|MILKMIMF_13
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1318490
            Orig. end    :: 1332807
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14317
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9317]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9317
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14317
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14317
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(166..1206)
                     /locus_tag="ctg13_1359"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
     CDS             complement(1206..1607)
                     /locus_tag="ctg13_1360"
                     /transl_table=11
                     /translation="MKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLL
                     YREHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVE
                     ISIEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             complement(1657..1956)
                     /locus_tag="ctg13_1361"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFLNMF"
     CDS             complement(1965..3224)
                     /locus_tag="ctg13_1362"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             complement(3520..3762)
                     /locus_tag="ctg13_1363"
                     /transl_table=11
                     /translation="MVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLN
                     LLWVKGRSDLSLRLEIIKRRLLYSFFLCQFHLGLR"
     CDS             complement(3939..4658)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_1364"
                     /sec_met_domain="Polysacc_synt (E-value: 4.7e-22, bitscore:
                     75.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKSFLL"
     CDS             complement(4861..5004)
                     /locus_tag="ctg13_1365"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(5001..5717)
                     /NRPS_PKS="Domain: Aminotran_5 (1-231). E-value: 1.4e-25.
                     Score: 81.8. Matches aSDomain:
                     nrpspksdomains_ctg13_1366_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 60.9; E-value:
                     1.8e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_1366"
                     /sec_met_domain="Aminotran_5 (E-value: 3.7e-22, bitscore:
                     75.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFD
                     IEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTG
                     EMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQS
                     GLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFK
                     VLKAALNHYNVTLPMS"
     aSDomain        complement(5025..5714)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg13_1366_Aminotran_5.1"
                     /evalue="1.40E-25"
                     /label="ctg13_1366_Aminotran_5.1"
                     /locus_tag="ctg13_1366"
                     /protein_end="231"
                     /protein_start="1"
                     /score="81.8"
                     /tool="antismash"
                     /translation="VYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDI
                     EKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGE
                     MHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSG
                     LVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKV
                     LKAALNHY"
     CDS             complement(5720..6124)
                     /locus_tag="ctg13_1367"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFIGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQEEILI"
     CDS             complement(6072..7259)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 57.9;
                     E-value: 1.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_1368"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.9e-18, bitscore:
                     63.6, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.6e-18, bitscore:
                     63.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFFKINIFDENRKKNIIKSWACHYY"
     CDS             complement(7276..8577)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_1369"
                     /sec_met_domain="CTP_transf_like (E-value: 3e-11, bitscore:
                     40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.1e-119, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.5e-61, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8598..9317)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_1370"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.5e-14, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9381..10529)
                     /locus_tag="ctg13_1371"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10540..12951)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_1372"
                     /sec_met_domain="Poly_export (E-value: 1.6e-16, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKEENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(12969..13337)
                     /locus_tag="ctg13_1373"
                     /transl_table=11
                     /translation="MDAIILQENIEGLLSLVRMLLPGGGSAGCVYLDDLSALQRSIHEK
                     INDLYSQRGETPEQDATLCLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLL
                     KQQLSAVCHGMQELCEIN"
     CDS             complement(13348..13926)
                     /locus_tag="ctg13_1374"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 tttgatcata aaacattccg ccatcagtcc aaacgccatc aatatctgta agtataagct
       61 ttatctcttt cattttttta gtattttacc cttatttatt aatcactact tagcttatag
      121 caggcagtac tctataccgt aatacaagtt gcagtaggaa tatatctatt caataaaatc
      181 aggatatatt atttcattcg ctgatatatc ttgtttagca aaatgaccaa ttacattttt
      241 tttatctatc catttataac catcaccagg actcagtaaa tgaatgtccg actcttgaat
      301 aatactacct gctggaatat attttcgagt ggcaatagaa cgttcaagtt ttatcttaga
      361 cttctccacc cctttttcta tataaagatc ttcagtacca agccaacact ctgctatgcg
      421 aatatctcga atcatacgat taaccccatc tggacctaaa gagccaagct ggtctgttcc
      481 tttcatatgc cgatcaattg ttacatgctt ttctataatt tccgctccca tcgctacagc
      541 agctgtagca gcagaaatac ctattgtatg atcagaaaaa cctatctcaa acttattgta
      601 atgcttcttc aaatatgtta ttgtacgtag attcaaatta tttggatgag ttggatactg
      661 agatacacaa tgtagaatag ctatattact atgatatctc gttatcacat ctaatgcatt
      721 gtcaagttct ctttgaccag ccattcctgt cgataatata ataggaatat gagtttctgc
      781 taatgcttca agcaatggta agttagtcaa atcacgacta gcaactttta gcctatccgg
      841 tgtgaacagt ttaagcaaag acagacatcc tttggcacat aacgtctcga taaaatctaa
      901 tcctaatgac ttagcatatt tataaatctc aaaatgcgct tgatcatcaa gctcaagaaa
      961 agcacgatgt tcaccataag tacgcccaaa agaattagga ttgtcatata tttgattcat
     1021 ttgagaaaca gccaattctt ctgataaatc tcttttagtc attttaacag cattcattgg
     1081 catgaaatcc ataccaaaaa catcctcatg tacaggtcgt gagattaatt caataatcaa
     1141 cttagccaag tcaacagaac cattatgatt ctgccctatt tcaccaataa tataagtatt
     1201 cttcattatt tagaattttt ttttatttgt tgtttcatca gttgaatgta ttctgcatgt
     1261 cttcgaacat agtctacaat cacttctatc gatatttcca ctcttttttc ttgtaaatcc
     1321 ctatatattc tctgtgctac agaaaaatct tctaacgtat caatcgtgag tcgaatatta
     1381 tgatgttttg acacgactgg agatcctgaa atccattgaa tattaaaaag ttcaggatga
     1441 ctatatatat aattagtaac atgttcacga tacaataaat catcagtaaa tcctataact
     1501 cgcttcagcg catcaagcgt tacaaattct ccccaaaaac cgaaatgagt tttaattgat
     1561 ggagtaccat caatatcaaa acttatataa tcgttacaag atttcattgc tatttcgacc
     1621 aattgccttg ccgcatgtac atctaaaaat ggattatcag aacatattca ggaatatacc
     1681 ctgtatatca aaatattcag caacatcaat gaatcgtttt aaaacatcat tctcctcacc
     1741 tctgaagcac tttaccccta atgcaagtgc cttcttttca ataggttcat tgataacaga
     1801 atttgttgta gcaataatta ctggaatatt cgatatagca gaaagcttat gaaccattaa
     1861 gtcaagaatc gattgattac catagaaagg tttcaatatt tttccaggca aacgtgtaga
     1921 acctaaacgt gcctgcacca caaatgcata attcatttta tttattatat ttcatttaaa
     1981 aatatgtcac atattctctt tgttgaatta tcatcttgaa attgattcat caataaagaa
     2041 atatgacgtc gatgttcagc atgaatatct ttcccagcca gaagtcccat cacagcatct
     2101 atcaattcat tataattgta aacaatatca cctgcacaaa aaaattctat tggctcaaat
     2161 gagaaacctc ttactctacg atattcttca atatcgtaga aattaaatat gactggctta
     2221 tttaccaata aaaaatcaaa ataggtagaa gtataatcag taatcattcc atctgaaaat
     2281 gacaaaagat catacaatcc atatttatat gtttgttcaa aaacaagtat acctttgggt
     2341 aaatcttttt ttaagactgt tttattctgc aaaggatgta atttaagaat taaagccgca
     2401 ttaaacttca atagtatttt cgataacttc aacaaatcac aatcaacata tccgagtatt
     2461 gaacgcaaat taccttcagt aacagtctca taatcacgaa aagttggagt ataaactata
     2521 tatttagtta catcatatcc cgcaaatttc gaaatttctc ttttaataac attgcaatta
     2581 tttttcgata tcaacaaatc atttctggga aatcctaaga ctttgaattt atcatatgag
     2641 attccacaat ctattgaaat tattctagca cttaaacaag aagtagcaat agagtaatca
     2701 aatgagttac atgttgtatt acgaaattta tcataagaat gatctcccat atgataatca
     2761 tctttgaatg gagtataata ccccaaacaa ataatctgtt gagagcgttt tttaaatgaa
     2821 aaatcataat aaaaagtagc tgtaaaacat ttacttgctc tacaaaaaca aaaaaaggca
     2881 tacaacatat ccttaaaaga tactttatta aagaaaaaac gtccaacaca tgcacataaa
     2941 aaagtacacc taatattagg atttatgcca taaatatatt cttgatattc tgaaatacga
     3001 gaagaatcat aaatttcaac atatatttta taatattcag cactatcttt ttttagcaaa
     3061 taatttaaca gaacgagaac attatctgac gaataattta taatatcata tttatctgtt
     3121 ctacaattag gatgaggaat aaaatacaat gatctactat caactggcac acaatggtta
     3181 attatcttta ctattacttg aaaaatcttt tttaatattt tcatctatgt ttttagtttt
     3241 aatgatcaat gttaaaataa aaaaaaagaa tctagcttaa aaagaaaaga aagtaaaata
     3301 tagaaggaca tcccagtaat acatccaatc acaattttta ctatatcagt ttcaaagaaa
     3361 gaaatacata taaaaacgat ccccccatta tgaaagagag tattaaactt ggaaatacat
     3421 ctttaacttg caactttaag gtcaaatcaa taagagaatt agtataatat gtattcaaat
     3481 atgtcgctat cagagagtaa ataactctac cccaacacat cacctcaagc ccaaatggaa
     3541 ttgacacaaa aagaatgaat atagcaatcg tctttttatt atttcaagac gtaacgacag
     3601 atcagatctt cctttaaccc ataataaatt caaattaatt tggctcaaat gatcaaacat
     3661 ccaatccaaa cataatatct gtaaaagaat aacaacccca gaccatttat ctgttaacaa
     3721 tagactaata ataggattag ccaaaacaag taaacctacc attaaaggaa aaattatata
     3781 tgaggataat ctgatataat ttcgatatgc gtttgttaaa catttatcat catcttgaat
     3841 ggaacttaaa ataggatacg ctactctaga aactaaagca tttaaattat tggaaggaaa
     3901 aatagcaaat tgttctgctc ttgtatagta accaagctct acaacagaaa actttttcct
     3961 attacaatgg tatacagatt acgatatact gtattgataa gacttgagat caataattta
     4021 gatccgaaat tgaataatct ttcaaaagaa cttttggaga aagtatgtaa aggtttccaa
     4081 tgaactaaac agtaaaacaa aattgtcaaa attatactat ttaagagagt ttgccaaact
     4141 aaagcccaaa ccccgcaacc gacataagcc atccatattc caatcacgcc tgatataaaa
     4201 gctgcaccta atgaaatttt agattgagtt ttaaagttta cagaaataat taatttcgtt
     4261 ctgtgaatag ccgataaagc atttattatc aacgacaatg ctataaaacg aattacaaga
     4321 actaaagtcg gcatattata aaagtctgca atcaaagaag ccgaaaaaaa caatatacca
     4381 tagaataata ctgcgacaag aatattaaaa taaaagacag tggcaaaatc ctcttcagtt
     4441 ctatcttttt tctggattaa agcatttgta aaaccgctat ctataaatac ttgagcgact
     4501 tgaagaaaaa tagctaacat cccgatcata ccataatccg atggtagtaa caaacgagct
     4561 aatattattt gaattataaa ctgtactcct tgtaaagaga aacgttctat agcgctccac
     4621 attattcctg atacagtttt ctgctttaga ttttccatta cttaaataca gtataaaaac
     4681 aactacattt accgatatca attatatttt tccaatattc tcactaattg gttattatct
     4741 tcttcgcccc ttaccgcaat tctaatatgg tctctcccac taaaagcaaa ttaccctaca
     4801 caaacattat ctcctataac taccgatgcc tttttataag aataaagaac tcctaatgca
     4861 tcacctcaaa ttaatattgc catatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc acccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga tttcttcttg caacacattt tccaccaccg
     5761 ataaatcagg acgttcgtaa acggaaaatt ccaaattaat atgaggcaaa ccataatatt
     5821 gacacacttc tacagcacgg gtactatatg ccccattatt cactataagc acccttttgt
     5881 cttcaggaag aagagaattt agacatatat caatattgat ggttcctgag ccacaaaata
     5941 atacagcggt atgtttttcc aaattcccat gagcaactct gaccaaatcg tcccgaagtt
     6001 gtttcatcat acctatgaat tctttctcgc gaggacaaat atccggaaca acttgtgcca
     6061 tttttacact gtcagtagta gtggcaggcc caggatttaa taatattttt ctttctattt
     6121 tcatcgaata tatttatttt aaaaaaatcc ataaaatgct ccttattctc tataggagta
     6181 gtcgtgggac gtcccaaatt ctcccgagaa tctattttaa cctttatttc caacaaaaca
     6241 ggaccacata actttggaag ctgcttcatt gcttcttcaa tttcaacttt tgtacaaaca
     6301 gtataagtat gcttatatcc gctcccccgg acaatagccg gaatatctaa actaaatcct
     6361 aaagtaggct gtcctcctac agactcgtga gcaccattgt taaacaaaat atgataatag
     6421 tttttaggag ataaatcgcc aatgttacta attgccccta aatgcataat aaatgctcca
     6481 tcaccatcca agcaataaac aggtctatct tgctttgcta tagcaatacc caaagagatt
     6541 gatgaactat gtcccataga gcctaccgtg agaaaatcat gttcatgacc ttgctctttc
     6601 atttctcgat attcaaataa ctcacgagaa agcttgccag tagtagaaac gaccactgaa
     6661 ttttcaggca gataatccac aactatttgc aaagcatcct cacgagataa aggataatta
     6721 catccgaact ctttttgaag tttatatttg ccaaaaacat ctttccgaat aattattgca
     6781 tgaggaatat tcttagtttt tgctgattgt atgatatcat ggagctgaat aaatgcatca
     6841 ttctcatttg aatcaagaat tatataagga atccgcattg ctttcaacaa atctaaagtt
     6901 acctcaccct gttttttatg ctgaggttca tcttttgttc ccggttcacc acgccagcca
     6961 atcatcaaaa gcattggaaa actgtatact tgttcatctg caagagacag cagaggatta
     7021 acagtattac ccaagccgga attttgcata taaaccacag gaaccttacc tgatgccata
     7081 taataacctg aagcaattcc tacagccgca ccttcattag cagctatgat atgtttctca
     7141 cgtgaagtat ggtctgtgat ataggcacaa atatttttta gtaatgagtc tggaactcct
     7201 gtaaaaaaat caacgtcatg actcagaaac gtttcataaa ctttttctac gcttaacata
     7261 atgatattcc tctttttatt tagtacctgg aatcagttcc aatatttctt ttatgggcat
     7321 acacagttcg cgcacctcta aagcacgttc attctctaat attatctttg cgacattcat
     7381 catagcagga taagcggcac gaagcatatg attagcataa ataattatat tcacacccca
     7441 atcacacaat tcagactcat aaatatgatc atatgtagta ggcacaacca cgataggtac
     7501 atgagcatac tgttttcgaa acgccaaaca aaattctttt atatcttcac ccgacttatt
     7561 tttgctatgt atcataatac cgtccgctcc cgcttggaca tatgcaaaag ctctctctaa
     7621 agcatcactt accggctttc ccgctataag gctctcaata cgagcgataa tcataaaatc
     7681 atcagtaatc tgagatgcct ttcctgcttt gatcttatta cagaaacctt cgattgtatc
     7741 ttgagtttga ataacatctg taccaaacaa tgaattcttt tttaatccaa ctttatcttc
     7801 aattattata gctgaaattc catgacgttc taaagtgcgt actgtaaata cgaaatgttc
     7861 aattttacca cctgtatctc catcaaaaat aataggttta gtagtacact ccagaatatt
     7921 attcaaatct tgcaatcggg tagttaaatc aaccgcctca atatcaggtt tacctttact
     7981 ggttgaatcc gtaaggctac tagaccacat tccgtcaaat acttccctct tatccccttt
     8041 taatatttcc tgattttcaa ttatcaagcc acatagtcca tcatgagctt ccaaaatacg
     8101 aactacgggt ttggcattta tcaaacgacg aagtgatttt aaacgtacat caggggttgt
     8161 acctatagcc ttaatatctt tatccaaaga agatgaatta attcccaaag tatatggaat
     8221 ttcgataacc tttcctccct gttcattcat cacttcaaat acgcgcacac gttcttcacg
     8281 taaaggcccg gttttccagt cgtcaccatg aattatatag tcaggtttaa tgcgtttgag
     8341 attctcaaca tagctccatt cttcttgagg aacaacttta catacgcctt taatattctg
     8401 aactacctct tttcgttgtt cataggtcag ataaggaagg cgtttatgct ccgcaatagc
     8461 tttatctgta agaagaccaa ttataacatc accgtattta gtagcctcat taataatgcg
     8521 gataagtcct ggatgcataa tatccgcagt catcccaata taaactgtct tactcataat
     8581 ttgatatatt attttaatta acaatacgga acaatatatt tctctgcata ttccaaatct
     8641 gatatgtcat cgatttcata ccatttcagc ccttctactt tatgcacata aacaggagat
     8701 tgagaacaag atattcgtag taattcatac tcatatccca aattgggttg ttcatcaaca
     8761 atactcgcat aatcagcaca cattattttg taaaaggaac cggatagttt atggatgccg
     8821 accaattcgc ctttagcgtt tagtttattc ttattgacag aacatgaaga aaggcgaaaa
     8881 ttatcatcat gttccacata atactgatct tgaaactttg tcactggagt tattagcatt
     8941 gcatctgccg caggacactc caataagctc attattgctt gtttctcaaa aatcaaatct
     9001 gactctaaca ataaaaaatc atcattgccc agaatctccc gcgtattata taaagtatac
     9061 atactatttg tttcagcata acgaggacta aaacaggttt caagcatagg atagtctgtc
     9121 ttcaattctt cataaacttc ttgtttatat cctgtaccga ttacaattcg ctcaatgtca
     9181 catgataaca aagtatcaat agaacgaact atcattggaa tacctcccac tttgacgaac
     9241 cctttaggta tcaattctgt atattggcca aaacgggttc ccatgcccgc agccattatc
     9301 atagctgtac gtatcattcg tttaataata tagtaagtga atttaattga tgtaagaatg
     9361 ttgtaaacga cgttttagca tcatttatcc tgttctatct ccttattttt cagttctttt
     9421 ctcaagctag ccagcagact tttgccaaaa aacacccaca cgagagtacc agatacggac
     9481 aggaacacaa ataataaaat ataaattttg agtcccatac ctgaaggttt caaaggtaca
     9541 acggcaggct caactactgc aaagactggc ttttcctcct gtactttggc tctggatacc
     9601 tgcaactgat tagcaacctg actatatatc tgataagcca aactcatgtc gttctgtaaa
     9661 cgctcctgct cagcacgtac actttgaaga accacattat catgggcgtc tacataatcc
     9721 gcatattttc tttgagcagc ataatattcc tgctgacgtt ctttaaacaa ccgttccaaa
     9781 tacgcacagt cttcttttac ttttgaagtt cgatacccaa taatatattc ctgtaattta
     9841 tgaacgacag aatctgctat aaccgcagtg atctgcggat tttgtaaggt gaccgtaatg
     9901 ctcgttatgg cggttttctt atcaatggat gcactaatct tctttttaag aaaattaatc
     9961 ttctcattta cttctttcgt caattcgata gttccttgcc gccctccact ggcaggaacc
    10021 gtatcttctc cgaataatga tttaactcct cctattacta tgcccggaaa acctataaga
    10081 taatcccacc aaggagatga ctcttcatcg agataagacc ccaaagtcat tttatcatcc
    10141 tttttagaaa cggagacttc catttctaaa agttccaata aaaaaggagt tgaagaaaca
    10201 atatctgctg aaagagaagc gttcaaggca tctgtgcttt cccctattag agccccatct
    10261 cccaaaaacg aggcagcaag tccggctaaa ccattacttc ccttcgcatt acccatttca
    10321 ggagaaaggg taacctttac tgtatattgc ttgggaatgc tcaatgccac cactatagca
    10381 attattactc ccactccagc agctttgcat agtactccac gaacagtaat aatcttataa
    10441 aaaatagcca tcaagtctat ttccatttca tcatctttcc ttttatccac ttcagaaaac
    10501 ggttcttgat aagattgctt ttcaatcata ataggtcatt tatttcttta tcaaattagc
    10561 aatagaagca atcatcattc ccaaagaact gaaggaagta gcataaccta aaatattagc
    10621 tatgttccct ttcttcttag ccttaccagg cacaataatc tcacaccccg gctcaatctg
    10681 tttcttacca ctacccttaa ccttcgtcac ctgaccattc atgtaaacaa tgaacttctt
    10741 actcttcctt gcattatcag aacagccacc ggcctgattc aggtaataat ccacattctt
    10801 tcccttcata taagaaaccg tattcggaac catgacagca ccattgatag ttacagtatt
    10861 agtattctta ggtatggaga tcacatcacc ttcacgtaag acaagatcgg cattactttt
    10921 aggattgctc aaggcttttt ccaaatctat tccaaccgta aaagtatctt caacacgaat
    10981 acccaaagag tcaatcatgg cttcgcccaa ttgcctgctc ataaggcgaa ttacatcacc
    11041 catacgtttc ttttcactag cgttagccac acgggtcagt ttcgcaccac gcagataggc
    11101 ataattggtc ggaccaccgg ctttattcac taaatcggaa agacgttcct cacggctggt
    11161 catggcgtaa tttcctccga aaaggatttc accttcaatg gctacattct gttgtgcctg
    11221 atagcccgga ctgcgacgga cataaacctg atcataaggc tcaaggataa aaccgggctg
    11281 accatctatt acaaaaccat cctttaaaga gaaggtatac atctgaccaa tcgtatcatt
    11341 atccgcagta ctacgaggat tcttgattcg tctcgatata tcaatacgga cagtagaggc
    11401 ggcttctttc aagccaccgg cctgaatgat cagatcctca agtgtcatgt tatccgcata
    11461 aggataggaa tcagggtggg caacctcacc gtgaactgtg acattacccc ggtcttccag
    11521 gtcatggata cttggaatgt agaggatgtc attcttcatt agggcaaggt ttggggaagt
    11581 gccgtccatg atagacttaa tgtctatctg aacaacttca ctggtcaggt cttcacgctg
    11641 gcgatagagg acggcacgat tcaggaaagc gtcaccggtc agaccctgag cttcatggac
    11701 aagttcgcgg atcgtgttca gtttaccgct gagctggtag ataccgggac gatagacagc
    11761 gccacggatt tccagtttgt ttgtgaagcg gttaaggatg gcttcggcgg ttactacgtc
    11821 accgttacgc attttataaa tgttgtaatc tatatctttg actgtgttga cttcgtattc
    11881 ctcaccattc tgacggacaa cacgtaatga acgggtgtag gcatcggctt caaagccgcc
    11941 ggcatatttg attaaagtgg caaggttctc ttctttcttc atttcaaaac gcataggacg
    12001 ttttaccttg ccgctgatct ttaccaatac atcataagcg ggaacaatca cgacgtcacc
    12061 ttcctgaagg cggatgtcat cctgtgtgtt gcctttcatg ataaattcgt agacgtcgat
    12121 ggtggcaata ttctttccgt tgcgtaccaa ctgaacgttt cggaggctac cgatatcact
    12181 cacaccgcct gcacgataaa gcgcatggaa gacggtagag aaggaagaaa gggcgtaggt
    12241 accgggctgt acgacttctc ccatcacatt aatctgaata gtacggatat tacctaacgt
    12301 cagacggatg tcggaagttg gatcggtcgt gttgttcaga ccgttatata ttttattcag
    12361 ggcgttcttc agatagtcat tggcggcaga gactgtcata ccgctaaggt tgacagggcc
    12421 gatcttctga atgttgatag taccttcagg agagatttgc tggcggatcg tgttctggct
    12481 cgcaccccag atatcaatga tgacttcatc accgggacca agacggtaat tggcaggagt
    12541 ggcaaggttg acactaggct cgaacgtcag gttgcgggta ttgaagatgt tacgtccgaa
    12601 gacctgatca ccacgggcaa ggtcctgagt agtcggatga tcctccagca tatcggaagt
    12661 attcttctta gtctcttcac gcaggcggga ttcgttgatg tccgtgcccg ttgatttcga
    12721 ggtatttaca ttgttctgct gctcgtatag ctgcttcaca cgcattgcct gttctttggt
    12781 tacaccctta cgggctagtt cggaagcaag ctgcttctgt tccttgcctt ggcggatgcc
    12841 gtcttttaca tattccagta cctgtgagtc actcatggac tgagccataa gcgagccact
    12901 tcccagcatc aaacagaaga gtagaatgct aaaaagtcgt tgtattttca ttgacaaata
    12961 aaaaagtttc agttgatttc acacagttcc tgcatcccat gacagacggc agataactgt
    13021 tgcttaagaa gagaaggggg aagaacatcg agaagagaca gagaacgggt caaaacagcc
    13081 tgttttcttt cttcgtcttc cggattggcg tacatcgaca cattatatcc ctgaaggatg
    13141 gccaaacaca gggtagcatc ctgctccggt gtctcccccc gttgagaata taaatcgtta
    13201 atcttttcgt ggatggatcg ttgtaatgct gaaagatcat ccaaatacac gcagcctgca
    13261 ctccccccac caggaagcag catacgtacc aaacttaata aaccctctat attttcttgt
    13321 aaaataatag catccatatc ccttgcctta aacagccgcc ataatcggct ctacataacc
    13381 gacaggcata tcaacacagg cgcatcccag catattcaag cgaacagcaa tcttactttt
    13441 accatccaca ttgaccagtt cgccaacaag acccgtcaac ggacctttga tcacgcgaac
    13501 cttttcgcca cgagccaaag gagaactgtt catgcttatc gattcttccg aataatcaag
    13561 catgaaacgg aaacgagcca tctgctcgtc aggaattaca gcaggactac tctcgccgcg
    13621 catcaccatg taacggctga cagtagaaaa actcaggact tccatgcgtt ccttagggtc
    13681 aacgtgtacg aagaccatca taggaagcaa gacggaggtg accagcttgc gacggtcgct
    13741 ccattggtgg aattcctgtt gaacgggaac gaaattctcg atacccatct tgtccagatg
    13801 ctcggaaacc ttcttttcat ggtgcatccg aaccaaagca acataccagc gttttgagtg
    13861 tgctacgcct tcccctgtcc cattaatagg cccagcattt agtgatttct tttttcttaa
    13921 aatcatattt ttttacccca tgtttatccg ttacttctta ggtaacgaac aagcataggg
    13981 caagcagaaa agggaacttt tttcaacgaa aacatcagaa gaggactggt attcaggaaa
    14041 taaagcagaa gtgaaggtgt ttttcatgaa ttggaataaa aaaagacata acacggatat
    14101 tgtcattttc cgcctgttat gcctgcattt gattcatttt ccgaaattaa tttcattttt
    14161 gtttgcgtat tttcataaat atgtccatct ttgcgccatg aatcattccg ttacctaaga
    14221 agtaacgcac accgataaac actgtatatc aagcttctaa atcagataca ctgacctact
    14281 ccgcaccgct ttacgtaaga caaattcatc cggttca
//
