LOCUS       gnlProkkaEOJHIADM_2    14315 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EOJHIADM_2.
ACCESSION   gnlProkkaEOJHIADM_2
VERSION     gnlProkkaEOJHIADM_2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 09:36:18
            Original ID  :: gnl|Prokka|EOJHIADM_2
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2511892
            Orig. end    :: 2526207
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14315
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9315]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9315
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14315
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14315
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(262..1206)
                     /locus_tag="ctg2_2463"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPW"
     CDS             complement(1206..1955)
                     /locus_tag="ctg2_2464"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             complement(1964..2266)
                     /locus_tag="ctg2_2465"
                     /transl_table=11
                     /translation="MITDYTSTYFDFLLVNKPVIFNFYDIEEYRRVRGFSFEPIEFFCA
                     GDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLMNQFQDDNSTKRICDIFLNEI"
     CDS             complement(2263..3222)
                     /locus_tag="ctg2_2466"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKIYPKVYLFLNKHINMDCMIFCHFQME"
     CDS             complement(3339..4658)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_2467"
                     /sec_met_domain="Polysacc_synt (E-value: 2.5e-29, bitscore:
                     100.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGSFLYVFLSLKLI"
     CDS             complement(4861..5004)
                     /locus_tag="ctg2_2468"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg2_2469_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2469"
                     /sec_met_domain="Aminotran_5 (E-value: 3.7e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_2469_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg2_2469_Aminotran_5.1"
                     /locus_tag="ctg2_2469"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..7256)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2470"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.6e-18, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.2e-18, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             complement(7273..8307)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 210;
                     E-value: 7e-64)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2471"
                     /sec_met_domain="phosphonates (E-value: 2.2e-119, bitscore:
                     395.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.7e-61, bitscore:
                     204.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTTGKPGLLREERVRVFEVMNEQGGKVIEIPYTLGINSSSLDKD
                     IKAIGTTPDVRLKSLRRLINAKPVVRILEAHDGLCGLIIENQEILKGDKREVFDGMWSS
                     SLTDSTSKGKPDIEAVDLTTRLQDLNNILECTTKPIIFDGDTGGKIEHFVFTVRTLERH
                     GISAIIIEDKVGLKKNSLFGTDVIQTQDTIEGFCNKIKAGKASQITDDFMIIARIESLI
                     AGKPVSDALERAFAYVQAGADGIMIHSKNKSGEDIKEFCLAFRKQYAHVPIVVVPTTYD
                     HIYESELCDWGVNIIIYANHMLRAAYPAMMNVAKIILENERALEVRELCMPIKEILELI
                     PGTK"
     CDS             complement(8273..8575)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2472"
                     /sec_met_domain="CTP_transf_like (E-value: 4e-12, bitscore:
                     44.0, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPFT"
     CDS             complement(8596..9315)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2473"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.9e-14, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             complement(9383..10531)
                     /locus_tag="ctg2_2474"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGEPLIGESTDALN
                     ASLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGV
                     KSLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQIT
                     AVIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVV
                     LQSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMG
                     LKIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKGDRTG"
     CDS             complement(10542..11288)
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 35.3;
                     E-value: 8.9e-11)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_2475"
                     /transl_table=11
                     /translation="MVSPVLSFEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSR
                     EERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIR
                     VEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTVSYMKGK
                     NVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNI
                     ANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(11263..12954)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 125.8;
                     E-value: 2.8e-38)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_2476"
                     /sec_met_domain="Poly_export (E-value: 1.5e-16, bitscore:
                     57.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFIL"
     CDS             complement(12972..13286)
                     /locus_tag="ctg2_2477"
                     /transl_table=11
                     /translation="MLLPGGGSAGCVYLDDLSALQRSIHEKINDLYSQRGETPEQDATL
                     CLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGMQELCEIN
                     "
     CDS             complement(13351..13830)
                     /locus_tag="ctg2_2478"
                     /transl_table=11
                     /translation="MHHEKKVSEHLDKMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMV
                     FVHVDPKERMEVLSFSTVSRYMVMRGESSPAVIPDEQMARFRFMLDYSEESISMNSSPL
                     ARGEKVRVIKGPLTGLVGELVNVDGKSKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 ttgatcataa aacattccgc catcagtcca aacgccatca atatctgtaa gtataagctt
       61 tatctctttc atttttttag tattttaccc ttatttatta atcactactt agcttatagc
      121 aggcagtact ctataccgta atacaagttg cagtaggaat atatctattc aataaaatca
      181 ggatatatta tttcattcgc tgatatatct tgtttagcaa aatgaccaat tacatttttt
      241 ttatctatcc atttataacc atcaccaggg actcagtaaa tgaatgtccg actcttgaat
      301 aatactacct gctggaatat attttcgagt ggcaatagaa cgttcaagtt ttatcttaga
      361 cttctccacc cctttttcta tataaagatc ttcagtacca agccaacact ctgctatgcg
      421 aatatctcga atcatacgat taaccccatc tggacctaaa gagccaagct ggtctgttcc
      481 tttcatatgc cgatcaattg ttacatgctt ttctataatt tccgctccca tcgctacagc
      541 agctgtagca gcagaaatac ctattgtatg atcagaaaaa cctatctcaa acttattgta
      601 atgcttcttc aaatatgtta ttgtacgtag attcaaatta tttggatgag ttggatactg
      661 agatacacaa tgtagaatag ctatattact atgatatctc gttatcacat ctaatgcatt
      721 gtcaagttct ctttgaccag ccattcctgt cgataatata ataggaatat gagtttctgc
      781 taatgcttca agcaatggta agttagtcaa atcacgacta gcaactttta gcctatccgg
      841 tgtgaacagt ttaagcaaag acagacatcc tttggcacat aacgtctcga taaaatctaa
      901 tcctaatgac ttagcatatt tataaatctc aaaatgcgct tgatcatcaa gctcaagaaa
      961 agcacgatgt tcaccataag tacgcccaaa agaattagga ttgtcatata tttgattcat
     1021 ttgagaaaca gccaattctt ctgataaatc tcttttagtc attttaacag cattcattgg
     1081 catgaaatcc ataccaaaaa catcctcatg tacaggtcgt gagattaatt caataatcaa
     1141 cttagccaag tcaacagaac cattatgatt ctgccctatt tcaccaataa tataagtatt
     1201 cttcattatt tagaattttt ttttatttgt tgtttcatca gttgaatgta ttctgcatgt
     1261 cttcgaacat agtctacaat cacttctatc gatatttcca ctcttttttc ttgtaaatcc
     1321 ctatatattc tctgtgctac agaaaaatct tctaacgtat caatcgtgag tcgaatatta
     1381 tgatgttttg acacgactgg agatcctgaa atccattgaa tattaaaaag ttcaggatga
     1441 ctatatatat aattagtaac atgttcacga tacaataaat catcagtaaa tcctataact
     1501 cgcttcagcg catcaagcgt tacaaattct ccccaaaaac cgaaatgagt tttaattgat
     1561 ggagtaccat caatatcaaa acttatataa tcgttacaag atttcattgc tatttcgacc
     1621 aattgccttg ccgcatgtac atctaaaaat ggattatcag aacatattcg gaatataccc
     1681 tgtatatcaa aatattcagc aacatcaatg aatcgtttta aaacatcatt ctcctcacct
     1741 ctgaagcact ttacccctaa tgcaagtgcc ttcttttcaa taggttcatt gataacagaa
     1801 tttgttgtag caataattac tggaatattc gatatagcag aaagcttatg aaccattaag
     1861 tcaagaatcg attgattacc atagaaaggt ttcaatattt ttccaggcaa acgtgtagaa
     1921 cctaaacgtg cctgcaccac aaatgcataa ttcattttat ttattatatt tcatttaaaa
     1981 atatgtcaca tattctcttt gttgaattat catcttgaaa ttgattcatc aataaagaaa
     2041 tatgacgtcg atgttcagca tgaatatctt tcccagccag aagtcccatc acagcatcta
     2101 tcaattcatt ataattgtaa acaatatcac ctgcacaaaa aaattctatt ggctcaaatg
     2161 agaaacctct tactctacga tattcttcaa tatcgtagaa attaaatatg actggcttat
     2221 ttaccaataa aaaatcaaaa taggtagaag tataatcagt aatcattcca tctgaaaatg
     2281 acaaaagatc atacaatcca tatttatatg tttgttcaaa aacaagtata cctttgggta
     2341 aatctttttt aagactgttt tattctgcaa aggatgtaat ttaagaatta aagccgcatt
     2401 aaacttcaat agtattttcg ataacttcaa caaatcacaa tcaacatatc cgagtattga
     2461 acgcaaatta ccttcagtaa cagtctcata atcacgaaaa gttggagtat aaactatata
     2521 tttagttaca tcatatcccg caaatttcga aatttctctt ttaataacat tgcaattatt
     2581 tttcgatatc aacaaatcat ttctgggaaa tcctaagact ttgaatttat catatgagat
     2641 tccacaatct attgaaatta ttctagcact taaacaagaa gtagcaatag agtaatcaaa
     2701 tgagttacat gttgtattac gaaatttatc ataagaatga tctcccatat gataatcatc
     2761 tttgaatgga gtataatacc ccaaacaaat aatctgttga gagcgttttt taaatgaaaa
     2821 atcataataa aaagtagctg taaaacattt acttgctcta caaaaacaaa aaaaggcata
     2881 caacatatcc ttaaaagata ctttattaaa gaaaaaacgt ccaacacatg cacataaaaa
     2941 agtacaccta atattaggat ttatgccata aatatattct tgatattctg aaatacgaga
     3001 agaatcataa atttcaacat atattttata atattcagca ctatcttttt ttagcaaata
     3061 atttaacaga acgagaacat tatctgacga ataatttata atatcatatt tatctgttct
     3121 acaattagga tgaggaataa aatacaatga tctactatca actggcacac aatggttaat
     3181 tatctttact attacttgaa aaatcttttt taatattttc atctatgttt ttagttttaa
     3241 tgatcaatgt taaaatacaa aaaaagaatc tagcttaaaa agaaaagaaa gtaaaatata
     3301 gaaggacatc ccagtaatac atccaatcac aatttttact atatcagttt caaagaaaga
     3361 aatacatata aaaacgatcc ccccattatg aaagagagta ttaaacttgg aaatacatct
     3421 ttaacttgca actttaaggt caaatcaata agagaattag tataatatgt attcaaatat
     3481 gtcgctatca gagagtaaat aactctaccc caacacatca cctcaagccc aaatggaatt
     3541 gacacaaaaa gaatgaatat agcaatcgtc ttttttatta tttcaagacg taacgacaga
     3601 tcagatcttc ctttaaccca taataaattc aaattaattt ggctcaaatg atcaaacatc
     3661 caatccaaac ataatatctg taaaagaata acaaccccag accatttatc tgttaacaat
     3721 agactaataa taggattagc caaaacaagt aaacctacca ttaaaggaaa aattatatat
     3781 gaggataatc tgatataatt tcgatatgcg tttgttaaac atttatcatc atcttgaatg
     3841 gaacttaaaa taggatacgc tactctagaa actaaagcat ttaaattatt ggaaggaaaa
     3901 atagcaaatt gttctgctct tgtatagtaa ccaagctcta caacagaaaa cttttttcct
     3961 attacaatgg tatacagatt acgatatact gtattgataa gacttgagat caataattta
     4021 gatccgaaat tgaataatct ttcaaaagaa cttttggaga aagtatgtaa aggtttccaa
     4081 tgaactaaac agtaaaacaa aattgtcaaa attatactat ttaagagagt ttgccaaact
     4141 aaagcccaaa ccccgcaacc gacataagcc atccatattc caatcacgcc tgatataaaa
     4201 gctgcaccta atgaaatttt agattgagtt ttaaagttta cagaaataat taatttcgtt
     4261 ctgtgaatag ccgataaagc atttattatc aacgacaatg ctataaaacg aattacaaga
     4321 actaaagtcg gcatattata aaagtctgca atcaaagaag ccgaaaaaaa caatatacca
     4381 tagaataata ctgcgacaag aatattaaaa taaaagacag tggcaaaatc ctcttcagtt
     4441 ctatcttttt tctggattaa agcatttgta aaaccgctat ctataaatac ttgagcgact
     4501 tgaagaaaaa tagctaacat cccgatcata ccataatccg atggtagtaa caaacgagct
     4561 aatattattt gaattataaa ctgtactcct tgtaaagaga aacgttctat agcgctccac
     4621 attattcctg atacagtttt ctgctttaga ttttccatta cttaaataca gtataaaaac
     4681 aactacattt accgatatca attatatttt tccaatattc tcactaattg gttattatct
     4741 tcttcgcccc ttaccgcaat tctaatatgg tctctcccac taaaagcaaa ttaccctaca
     4801 caaacattat ctcctataac taccgatgcc tttttataag aataaagaac tcctaatgca
     4861 tcacctcaaa ttaatattgc catatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc acccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga ttttcttgca acacattttc caccaccgat
     5761 aaatcaggac gttcgtaaac ggaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgggt actatatgcc ccattattca ctataagcac ccttttgtct
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagcggtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct attttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccgaactctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gctgaataaa tgcatcattc
     6841 tcatttgaat caagaattat ataaggaatc cgcattgctt tcaacaaatc taaagttacc
     6901 tcaccctgtt ttttatgctg aggttcatct tttgttcccg gttcaccacg ccagccaatc
     6961 atcaaaagca ttggaaaact gtatacttgt tcatctgcaa gagacagcag aggattaaca
     7021 gtattaccca agccggaatt ttgcatataa accacaggaa ccttacctga tgccatataa
     7081 taacctgaag caattcctac agccgcacct tcattagcag ctatgatatg tttctcacgt
     7141 gaagtatggt ctgtgatata ggcacaaata ttttttagta atgagtctgg aactcctgta
     7201 aaaaaatcaa cgtcatgact cagaaacgtt tcataaactt tttctacgct taacataatg
     7261 atattcctct ttttatttag tacctggaat cagttccaat atttctttta tgggcataca
     7321 cagttcgcgc acctctaaag cacgttcatt ctctaatatt atctttgcga cattcatcat
     7381 agcaggataa gcggcacgaa gcatatgatt agcataaata attatattca caccccaatc
     7441 acacaattca gactcataaa tatgatcata tgtagtaggc acaaccacga taggtacatg
     7501 agcatactgt tttcgaaacg ccaaacaaaa ttcttttata tcttcacccg acttattttt
     7561 gctatgtatc ataataccgt ccgctcccgc ttggacatat gcaaaagctc tctctaaagc
     7621 atcacttacc ggctttcccg ctataaggct ctcaatacga gcgataatca taaaatcatc
     7681 agtaatctga gatgcctttc ctgctttgat cttattacag aaaccttcga ttgtatcttg
     7741 agtttgaata acatctgtac caaacaatga attctttttt aatccaactt tatcttcaat
     7801 tattatagct gaaattccat gacgttctaa agtgcgtact gtaaatacga aatgttcaat
     7861 tttaccacct gtatctccat caaaaataat aggtttagta gtacactcca gaatattatt
     7921 caaatcttgc aatcgggtag ttaaatcaac cgcctcaata tcaggtttac ctttactggt
     7981 tgaatccgta aggctactag accacattcc gtcaaatact tccctcttat ccccttttaa
     8041 tatttcctga ttttcaatta tcaagccaca tagtccatca tgagcttcca aaatacgaac
     8101 tacgggtttg gcatttatca aacgacgaag tgattttaaa cgtacatcag gggttgtacc
     8161 tatagcctta atatctttat ccaaagaaga tgaattaatt cccaaagtat atggaatttc
     8221 gataaccttt cctccctgtt cattcatcac ttcaaatacg cgcacacgtt cttcacgtaa
     8281 aaggcccggt tttccagtcg tcaccatgaa ttatatagtc aggtttaatg cgtttgagat
     8341 tctcaacata gctccattct tcttgaggaa caactttaca tacgccttta atattctgaa
     8401 ctacctcttt tcgttgttca taggtcagat aaggaaggcg tttatgctcc gcaatagctt
     8461 tatctgtaag aagaccaatt ataacatcac cgtatttagt agcctcatta ataatgcgga
     8521 taagtcctgg atgcataata tccgcagtca tcccaatata aactgtctta ctcataattt
     8581 gatatattat tttaattaac aatacggaac aatatatttc tctgcatatt ccaaatctga
     8641 tatgtcatcg atttcatacc atttcagccc ttctacttta tgcacataaa caggagattg
     8701 agaacaagat attcgtagta attcatactc atatcccaaa ttgggttgtt catcaacaat
     8761 actcgcataa tcagcacaca ttattttgta aaaggaaccg gatagtttat ggatgccgac
     8821 caattcgcct ttagcgttta gtttattctt attgacagaa catgaagaaa ggcgaaaatt
     8881 atcatcatgt tccacataat actgatcttg aaactttgtc actggagtta ttagcattgc
     8941 atctgccgca ggacactcca ataagctcat tattgcttgt ttctcaaaaa tcaaatctga
     9001 ctctaacaat aaaaaatcat cattgcccag aatctcccgc gtattatata aagtatacat
     9061 actatttgtt tcagcataac gaggactaaa acaggtttca agcataggat agtctgtctt
     9121 caattcttca taaacttctt gtttatatcc tgtaccgatt acaattcgct caatgtcaca
     9181 tgataacaaa gtatcaatag aacgaactat cattggaata cctcccactt tgacgaaccc
     9241 tttaggtatc aattctgtat attggccaaa acgggttccc atgcccgcag ccattatcat
     9301 agctgtacgt atcattcgtt taataatata gtaagtgaat ttaattgatg taagaatgtt
     9361 gtaaacgacg ttttagcatc atttatcctg ttctatctcc cttatttttc agttcttttc
     9421 tcaagctagc cagcagactt ttgccaaaaa acacccacac gagagtacca gatacggaca
     9481 ggaacacaaa taataaaata taaattttga gtcccatacc tgaaggtttc aaaggtacaa
     9541 cggcaggctc aactactgca aagactggct tttcctcctg tactttggct ctggatacct
     9601 gcaactgatt agcaacctga ctatatatct gataagccaa actcatgtcg ttctgtaaac
     9661 gctcctgctc agcacgtaca ctttgaagaa ccacattatc atgggcgtct acataatccg
     9721 catattttct ttgagcagca taatattcct gctgacgttc tttaaacaac cgttccaaat
     9781 acgcacagtc ttcttttact tttgaagttc gatacccaat aatatattcc tgtaatttat
     9841 gaacgacaga atctgctata accgcagtga tctgcggatt ttgtaaggtg accgtaatgc
     9901 tcgttatggc ggttttctta tcaatggatg cactaatctt ctttttaaga aaattaatct
     9961 tctcatttac ttctttcgtc aattcgatag ttccttgccg ccctccactg gcaggaaccg
    10021 tatcttctcc gaataatgat ttaactcctc ctattactat gcccggaaaa cctataagat
    10081 aatcccacca aggagatgac tcttcatcga gataagaccc caaagtcatt ttatcatcct
    10141 ttttagaaac ggagacttcc atttctaaaa gttccaataa aaaaggagtt gaagaaacaa
    10201 tatctgctga aagagaagcg ttcaaggcat ctgtgctttc ccctattaga ggttccccat
    10261 ctcccaaaaa cgaggcagca agtccggcta aaccattact tcccttcgca ttacccattt
    10321 caggagaaag ggtaaccttt actgtatatt gcttgggaat gctcaatgcc accactatag
    10381 caattattac tcccactcca gcagctttgc atagtactcc acgaacagta ataatcttat
    10441 aaaaaatagc catcaagtct atttccattt catcatcttt ccttttatcc acttcagaaa
    10501 acggttcttg ataagattgc ttttcaatca taataggtca tttatttctt tatcaaatta
    10561 gcaatagaag caatcatcat tcccaaagaa ctgaaggaag tagcataacc taaaatatta
    10621 gctatgttcc ctttcttctt agccttacca ggcacaataa tctcacaccc cggctcaatc
    10681 tgtttcttac cactaccctt aaccttcgtc acctgaccat tcatgtaaac aatgaacttc
    10741 ttactcttcc ttgcattatc agaacagcca ccggcctgat tcaggtaata atccacattc
    10801 tttcccttca tataagaaac cgtattcgga accatgacag caccattgat agttacagta
    10861 ttagtattct taggtatgga gatcacatca ccttcacgta agacaagatc ggcattactt
    10921 ttaggattgc tcaaggcttt ttccaaatct attccaaccg taaaagtatc ttcaacacga
    10981 atacccaaag agtcaatcat ggcttcgccc aattgcctgc tcataaggcg aattacatca
    11041 cccatacgtt tcttttcact agcgttagcc acacgggtca gtttcgcacc acgcagatag
    11101 gcataattgg tcggaccacc ggctttattc actaaatcgg aaagacgttc ctcacggctg
    11161 gtcatggcgt aatttcctcc gaaaaggatt tcaccttcaa tggctacatt ctgttgtgcc
    11221 tgatagccag gactgcgacg gacataaacc tgatcataag gctcaaagga taaaaccggg
    11281 ctgaccatct attacaaaac catcctttaa agagaaggta tacatctgac caatcgtatc
    11341 attatccgca gtactacgag gattcttgat tcgtctcgat atatcaatac ggacagtaga
    11401 ggcggcttct ttcaagccac cggcctgaat gatcagatcc tcaagtgtca tgttatccgc
    11461 ataaggatag gaatcagggt gggcaacctc accgtgaact gtgacattac cccggtcttc
    11521 caggtcatgg atacttggaa tgtagaggat gtcattcttc attagggcaa ggtttgggga
    11581 agtgccgtcc atgatagact taatgtctat ctgaacaact tcactggtca ggtcttcacg
    11641 ctggcgatag aggacggcac gattcaggaa agcgtcaccg gtcagaccct gagcttcatg
    11701 gacaagttcg cggatcgtgt tcagtttacc gctgagctgg tagataccgg gacgatagac
    11761 agcgccacgg atttccagtt tgtttgtgaa gcggttaagg atggcttcgg cggttactac
    11821 gtcaccgtta cgcattttat aaatgttgta atctatatct ttgactgtgt tgacttcgta
    11881 ttcctcacca ttctgacgga caacacgtaa tgaacgggtg taggcatcag cttcaaagcc
    11941 gccggcatat ttaatgagag tagcaaggtt ctcgtctttc ttcatttcaa aacgcatagg
    12001 acgttttacc ttgccgctaa tctttaccaa tacatcatag gcaggaacaa tcacaacgtc
    12061 accttcctgt aggcggatgt catcctgtgt gttgcctttc ataatgaatt cgtagacgtc
    12121 gatggtggca atattctttc cgttgcgtac caactgaacg tttcggaggc taccgatatc
    12181 actcacaccg cctgcacgat aaagcgcatg gaagacggta gagaaggaag aaagggcgta
    12241 ggtaccgggc tgtacgactt ctcccatcac attaatctga atagtacgga tattacctaa
    12301 cgtcagacgg atgtcggaag taggatcggt agtattattc agaccgttat atattttatt
    12361 cagggcgttc ttcagatagt cattggcggc agagactgtc ataccgctaa ggttgacagg
    12421 gccgatcttc tgaatgttga tagtaccttc aggagagatt tgctggcgga tcgtgttctg
    12481 gctcgcaccc cagatatcaa tgatgacttc atcaccggga ccaagacggt aattggcagg
    12541 agtggcaagg ttgacactag gctcgaacgt caggttgcgg gtattgaaga tgttacgtcc
    12601 gaagacctga tcaccacggg caaggtcctg agtagtcgga tgatcctcca gcatatcgga
    12661 agtattcttc ttagtctctt cacgcaggcg ggattcgttg atgtccgtgc ccgttgattt
    12721 cgaggtattt acattgttct gctgctcgta tagctgcttc acacgcattg cctgttcttt
    12781 ggttacaccc ttacgggcta gttcggaagc aagctgcttc tgttccttgc cttggcggat
    12841 gccgtctttt acatattcca gtacctgtga gtcactcatg gactgagcca taagcgagcc
    12901 acttcccagc atcaaacaga agagtagaat gctaaaaagt cgttgtattt tcattgacaa
    12961 ataaaaaagt ttcagttgat ttcacacagt tcctgcatcc catgacagac ggcagataac
    13021 tgttgcttaa gaagagaagg gggaagaaca tcgagaagag acagagaacg ggtcaaaaca
    13081 gcctgttttc tttcttcgtc ttccggattg gcgtacatcg acacattata tccctgaagg
    13141 atggccaaac acagggtagc atcctgctcc ggtgtctccc cccgttgaga atataaatcg
    13201 ttaatctttt cgtggatgga tcgttgtaat gctgaaagat catccaaata cacgcagcct
    13261 gcactccccc caccaggaag cagcatacgt accaaactta ataaaccctc tatattttct
    13321 tgtaaaataa tagcatccat atcccttgcc ttaaacagcc gccataatcg gctctacata
    13381 accgacaggc atatcaacac aggcgcatcc cagcatattc aagcgaacag caatcttact
    13441 tttaccatcc acattgacca gttcgccaac aagacccgtc aacggacctt tgatcacgcg
    13501 aaccttttcg ccacgagcca aaggagaact gttcatgctt atcgattctt ccgaataatc
    13561 aagcatgaaa cggaaacgag ccatctgctc gtcaggaatt acagcaggac tactctcgcc
    13621 gcgcatcacc atgtaacggc tgacagtaga aaaactcagg acttccatgc gttccttagg
    13681 gtcaacgtgt acgaagacca tcataggaag caagacggag gtgaccagct tgcgacggtc
    13741 gctccattgg tggaattcct gttgaacggg aacgaaattc tcgataccca tcttgtccag
    13801 atgctcggaa accttctttt catggtgcat ccgaaccaaa gcaacatacc agcgttttga
    13861 gtgtgctacg ccttcccctg tcccattaat aggcccagca tttagtgatt tctttttctt
    13921 aaaatcatat ttttttaccc catgtttatc cgttacttct taggtaacga acaagcatag
    13981 ggcaagcaga aaagggaact tttttcaacg aaaacatcag aagaggactg gtattcagga
    14041 aataaagcag aagtgaaggt gtttttcatg aattggaata aaaaaaagac ataacacgga
    14101 tattgtcatt ttccgcctgt tatgcctgca tttgattcat tttccgaaat taatttcatt
    14161 tttgtttgcg tattttcata aatatgtcca tctttgcgcc atgaatcatt ccgttaccta
    14221 agaagtaacg cacaccgata aacactgtat atcaagcttc taaatcagat acactgacct
    14281 actccgcacc gctttacgta agacaaattc atccg
//
