LOCUS       gnlProkkaNAFPDFEE_1    14312 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NAFPDFEE_1.
ACCESSION   gnlProkkaNAFPDFEE_1
VERSION     gnlProkkaNAFPDFEE_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:07:01
            Original ID  :: gnl|Prokka|NAFPDFEE_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 5810868
            Orig. end    :: 5825180
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14312
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9312]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9312
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14312
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14312
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(161..1003)
                     /locus_tag="ctg1_7718"
                     /transl_table=11
                     /translation="MTILILLGVLMVNIVLFLSLDDQAHFEIYKYAKSLGLDFIETLCA
                     KGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDNALDVITR
                     YHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATVAVAMGAE
                     IIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVEKSKIKLE
                     RSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEIIYPDFIE"
     CDS             complement(942..1202)
                     /locus_tag="ctg1_7719"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLEP"
     CDS             complement(1202..1951)
                     /locus_tag="ctg1_7720"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             complement(1960..3219)
                     /locus_tag="ctg1_7721"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             complement(3234..4622)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7722"
                     /sec_met_domain="Polysacc_synt (E-value: 9.7e-29, bitscore:
                     99.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIADFYNMPTLVLVI
                     RFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWMAYVGCGVWALVW
                     QTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLINTVYRNLYTIVIG
                     KKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCLTNAYRNYIRLSS
                     YIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLNLLWVKGRS
                     DLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYYTNSLIDLTLKLQ
                     VKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFLYF
                     NIDH"
     CDS             complement(4861..5004)
                     /locus_tag="ctg1_7723"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             complement(5001..6122)
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg1_7724_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7724"
                     /sec_met_domain="Aminotran_5 (E-value: 1e-28, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        complement(5025..6032)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_7724_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg1_7724_Aminotran_5.1"
                     /locus_tag="ctg1_7724"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             complement(6132..6839)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 59.3;
                     E-value: 5.1e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7725"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-18, bitscore:
                     65.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMHLFRLHDIIQSAKTKNIPHAIIIRKDVFGKYKLQKEFGCNYPL
                     SREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKEQGHEHDFLTVGSMGHSSSISL
                     GIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNYYHILFNNGAHESVGGQPTLGF
                     SLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGPVLLEIKVKIDSRENLGRPTTT
                     PIENKEHFMDFLK"
     CDS             complement(6814..7257)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7726"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.9e-17, bitscore:
                     62.3, seeds: 75, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQAP"
     CDS             complement(7274..8065)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 199.6;
                     E-value: 1e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7727"
                     /sec_met_domain="phosphonates (E-value: 3e-104, bitscore:
                     347.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 7e-58, bitscore:
                     194.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRL
                     QDLNNILECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTD
                     VIQTQDTIEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADG
                     IMIHSKNKSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHML
                     RAAYPAMMNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             complement(8079..8576)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7728"
                     /sec_met_domain="CTP_transf_like (E-value: 1.4e-11,
                     bitscore: 43.7, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     GS"
     CDS             complement(8597..8782)
                     /locus_tag="ctg1_7729"
                     /transl_table=11
                     /translation="MCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEID
                     DISDLEYAEKYIVPYC"
     CDS             complement(8782..9312)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7730"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.6e-10, bitscore:
                     39.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGITRFGQYTELIPKGFVKVGGIPMIVRSIDTLLSC
                     DIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLLE
                     SDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKGE
                     LVGIHKLSGYFTK"
     CDS             complement(9376..10365)
                     /locus_tag="ctg1_7731"
                     /transl_table=11
                     /translation="MALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGES
                     TDALNASLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGI
                     VIGGVKSLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQ
                     NPQITAVIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDA
                     HDNVVLQSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLK
                     PSGMGLKIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             complement(10313..10525)
                     /locus_tag="ctg1_7732"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKACW
                     SGSNNCYSGGIEHSQAIYSKGYPFS"
     CDS             complement(10536..10805)
                     /locus_tag="ctg1_7733"
                     /transl_table=11
                     /translation="MKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQI
                     EPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             complement(10802..11761)
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 56.7;
                     E-value: 2.7e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_7734"
                     /transl_table=11
                     /translation="MALSIVPVSTRLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQRE
                     DLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYA
                     DNMTLEDLIIQAGGLKEAASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQ
                     PGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNY
                     AYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSN
                     PKSNADLVLREGDVISIPKNTNTVTINGAVMVRIRFLI"
     CDS             complement(11718..11942)
                     /locus_tag="ctg1_7735"
                     /transl_table=11
                     /translation="MPAALKADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVV
                     TAEAILNRFTNKLEIRGAVYRPGIYQAQR"
     CDS             complement(11920..12906)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 145.1;
                     E-value: 3.6e-44)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_7736"
                     /sec_met_domain="Poly_export (E-value: 1.7e-16, bitscore:
                     58.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQKQLASELARKGVTK
                     EQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLEDHPTTQDLARGDQVF
                     GRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIRQQISPEGTINIQKI
                     GPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNIRTIQINVMGEVVQP
                     GTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRL
                     QEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGFEG"
     CDS             complement(12966..13334)
                     /locus_tag="ctg1_7737"
                     /transl_table=11
                     /translation="MDAIILQENIEGLLSLVRMLLPGGGSAGCVYLDDLSALQRSIHEK
                     INDLYSQRGETPEQDATLCLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLL
                     KQQLSAVCHGMQELCEIN"
     CDS             complement(13345..13923)
                     /locus_tag="ctg1_7738"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
ORIGIN
        1 tcataaaaca ttccgccatc agtccaaacg ccatcaatat ctgtaagtat aagctttatc
       61 tctttcattt ttttagtatt ttacccttat ttattaatca ctacttagct tatagcaggc
      121 agtactctat accgtaatac aagttgcagt aggaatatat ctattcaata aaatcaggat
      181 atattatttc attcgctgat atatcttgtt tagcaaaatg accaattaca ttttttttat
      241 ctatccattt ataaccatca ccaggactca gtaaatgaat gtccgactct tgaataatac
      301 tacctgctgg aatatatttt cgagtggcaa tagaacgttc aagttttatc ttagacttct
      361 ccaccccttt ttctatataa agatcttcag taccaagcca acactctgct atgcgaatat
      421 ctcgaatcat acgattaacc ccatctggac ctaaagagcc aagctggtct gttcctttca
      481 tatgccgatc aattgttaca tgcttttcta taatttccgc tcccatcgct acagcaactg
      541 tagcagcaga aatacctatt gtatgatcag aaaaacctat ctcaaactta ttgtaatgct
      601 tcttcaaata tgttattgta cgtagattca aattatttgg atgagttgga tactgagata
      661 cacaatgtag aatagctata ttactatgat atctcgttat cacatctaat gcattgtcaa
      721 gttctctttg accagccatt cctgtcgata atataatagg aatatgagtt tctgctaatg
      781 cttcaagcaa tggtaagtta gtcaaatcac gactagcaac ttttagccta tccggtgtga
      841 acagtttaag caaagacaga catcctttgg cacataacgt ctcgataaaa tctaatccta
      901 atgacttagc atatttataa atctcaaaat gcgcttgatc atcaaggctc aagaaaagca
      961 cgatgttcac cataagtacg cccaaaagaa ttaggattgt catatatttg attcatttga
     1021 gaaacagcca attcttctga taaatctctt ttagtcattt taacagcatt cattggcatg
     1081 aaatccatac caaaaacatc ctcatgtaca ggtcgtgaga ttaattcaat aatcaactta
     1141 gccaagtcaa cagaaccatt atgattctgc cctatttcac caataatata agtattcttc
     1201 attatttaga attttttttt atttgttgtt tcatcagttg aatgtattct gcatgtcttc
     1261 gaacatagtc tacaatcact tctatcgata tttccactct tttttcttgt aaatccctat
     1321 atattctctg tgctacagaa aaatcttcta acgtatcaat cgtgagtcga atattatgat
     1381 gttttgacac gactggagat cctgaaatcc attgaatatt aaaaagttca ggatgactat
     1441 atatataatt agtaacatgt tcacgataca ataaatcatc agtaaatcct ataactcgct
     1501 tcagcgcatc aagcgttaca aattctcccc aaaaaccgaa atgagtttta attgatggag
     1561 taccatcaat atcaaaactt atataatcgt tacaagattt cattgctatt tcgaccaatt
     1621 gccttgccgc atgtacatct aaaaatggat tatcagaaca tattcggaat ataccctgta
     1681 tatcaaaata ttcagcaaca tcaatgaatc gttttaaaac atcattctcc tcacctctga
     1741 agcactttac ccctaatgca agtgccttct tttcaatagg ttcattgata acagaatttg
     1801 ttgtagcaat aattactgga atattcgata tagcagaaag cttatgaacc attaagtcaa
     1861 gaatcgattg attaccatag aaaggtttca atatttttcc aggcaaacgt gtagaaccta
     1921 aacgtgcctg caccacaaat gcataattca ttttatttat tatatttcat ttaaaaatat
     1981 gtcacatatt ctctttgttg aattatcatc ttgaaattga ttcatcaata aagaaatatg
     2041 acgtcgatgt tcagcatgaa tatctttccc agccagaagt cccatcacag catctatcaa
     2101 ttcattataa ttgtaaacaa tatcacctgc acaaaaaaat tctattggct caaatgagaa
     2161 acctcttact ctacgatatt cttcaatatc gtagaaatta aatatgactg gcttatttac
     2221 caataaaaaa tcaaaatagg tagaagtata atcagtaatc attccatctg aaaatgacaa
     2281 aagatcatac aatccatatt tatatgtttg ttcaaaaaca agtatacctt tgggtaaatc
     2341 tttttttaag actgttttat tctgcaaagg atgtaattta agaattaaag ccgcattaaa
     2401 cttcaatagt attttcgata acttcaacaa atcacaatca acatatccga gtattgaacg
     2461 caaattacct tcagtaacag tctcataatc acgaaaagtt ggagtataaa ctatatattt
     2521 agttacatca tatcccgcaa atttcgaaat ttctctttta ataacattgc aattattttt
     2581 cgatatcaac aaatcatttc tgggaaatcc taagactttg aatttatcat atgagattcc
     2641 acaatctatt gaaattattc tagcacttaa acaagaagta gcaatagagt aatcaaatga
     2701 gttacatgtt gtattacgaa atttatcata agaatgatct cccatatgat aatcatcttt
     2761 gaatggagta taatacccca aacaaataat ctgttgagag cgttttttaa atgaaaaatc
     2821 ataataaaaa gtagctgtaa aacatttact tgctctacaa aaacaaaaaa aggcatacaa
     2881 catatcctta aaagatactt tattaaagaa aaaacgtcca acacatgcac ataaaaaagt
     2941 acacctaata ttaggattta tgccataaat atattcttga tattctgaaa tacgagaaga
     3001 atcataaatt tcaacatata ttttataata ttcagcacta tcttttttta gcaaataatt
     3061 taacagaacg agaacattat ctgacgaata atttataata tcatatttat ctgttctaca
     3121 attaggatga ggaataaaat acaatgatct actatcaact ggcacacaat ggttaattat
     3181 ctttactatt acttgaaaaa tcttttttaa tattttcatc tatgttttta gttttaatga
     3241 tcaatgttaa aatacaaaaa aaaagaatct agcttaaaaa gaaaagaaag taaaatatag
     3301 aaggacatcc cagtaataca tccaatcaca atttttacta tatcagtttc aaagaaagaa
     3361 atacatataa aaacgatccc ccccattatg aaagagagta ttaaacttgg aaatacatct
     3421 ttaacttgca actttaaggt caaatcaata agagaattag tataatatgt attcaaatat
     3481 gtcgctatca gagagtaaat aactctaccc caacacatca cctcaagccc aaatggaatt
     3541 gacacaaaaa gaatgaatat agcaatcgtc ttttttatta tttcaagacg taacgacaga
     3601 tcagatcttc ctttaaccca taataaattc aaattaattt ggctcaaatg atcaaacatc
     3661 caatccaaac ataatatctg taaaagaata acaaccccag accatttatc tgttaacaat
     3721 agactaataa taggattagc caaaacaagt aaacctacca ttaaaggaaa aattatatat
     3781 gaggataatc tgatataatt tcgatatgcg tttgttaaac atttatcatc atcttgaatg
     3841 gaacttaaaa taggatacgc tactctagaa actaaagcat ttaaattatt ggaaggaaaa
     3901 atagcaaatt gttctgctct tgtatagtaa ccaagctcta caacagaaaa cttttttcct
     3961 attacaatgg tatacagatt acgatatact gtattgataa gacttgagat caataattta
     4021 gatccgaaat tgaataatct ttcaaaagaa cttttggaga aagtatgtaa aggtttccaa
     4081 tgaactaaac agtaaaacaa aattgtcaaa attatactat ttaagagagt ttgccaaact
     4141 aaagcccaaa ccccgcaacc gacataagcc atccatattc caatcacgcc tgatataaaa
     4201 gctgcaccta atgaaatttt agattgagtt ttaaagttta cagaaataat taatttcgtt
     4261 ctgtgaatag ccgataaagc atttattatc aacgacaatg ctataaaacg aattacaaga
     4321 actaaagtcg gcatattata aaagtctgca atcaaagaag ccgaaaaaaa caatatacca
     4381 tagaataata ctgcgacaag aatattaaaa taaaagacag tggcaaaatc ctcttcagtt
     4441 ctatcttttt tctggattaa agcatttgta aaaccgctat ctataaatac ttgagcgact
     4501 tgaagaaaaa tagctaacat cccgatcata ccataatccg atggtagtaa caaacgagct
     4561 aatattattt gaattataaa ctgtactcct tgtaaagaga aacgttctat agcgctccac
     4621 attattcctg atacagtttt ctgctttaga ttttccatta cttaaataca gtataaaaac
     4681 aactacattt accgatatca attatatttt tccaatattc tcactaattg gttattatct
     4741 tcttcgcccc ttaccgcaat tctaatatgg tctctcccac taaaagcaaa ttaccctaca
     4801 caaacattat ctcctataac taccgatgcc tttttataag aataaagaac tcctaatgca
     4861 tcacctcaaa ttaatattgc catatttgcc tactaagcga aagctacgaa taggcactcc
     4921 agaaataaca ctttccggat ggaagtgtat accacgaagg gaaaaataaa aatgacgaat
     4981 cttcaataat atttctgcaa tcatgacatc ggtaatgtga cgttataatg atttaatgca
     5041 gcttttagta ctttaaagaa gttctcaata tcatctactt ctatctctcc taaagcacag
     5101 attctaaaag tatcctcagt tgatatctta cctggataaa tcgtaaatcc acgctcataa
     5161 caataatcat gtattttctc aaaatcccag ttgggatctt ctgggtattg aactgagaca
     5221 accagtcctg actgccattc acgctttatt acacttttaa gaccaatttc atttatacct
     5281 gaatgaatag cctcaaaaac tcttttgtga cgggcaaact tagcttcttc acccacttca
     5341 aaatattcat ttaatgcctg acgagtggcg taaatagttt gtaccggtgg agtaaaatgc
     5401 atttcacctg ttctctcaaa attctcatac tgcaaataaa gattacaata gtaagaacgc
     5461 ttgggatatt tttttgaaaa cttaatctgt tcctcattgc ctataataaa agaaagacct
     5521 gtcatcgctt gaagtccttt ttgagcagat gccatacaaa aatccacatt atctttctct
     5581 atatcaaaag gaatcatgcc caaagaagaa gtagtatcga cgacaaattt agcctgatat
     5641 ttatgagcta tagcgcccat ctcgcgaata gggttcagaa ttcctgtacc cgtctcgtga
     5701 tgagtagtat aaaccatagc tatatcagga ttttcttgca acacattttc caccaccgat
     5761 aaatcaggac gttcgtaaac ggaaaattcc aaattaatat gaggcaaacc ataatattga
     5821 cacacttcta cagcacgggt actatatgcc ccattattca ctataagcac ccttttgtct
     5881 tcaggaagaa gagaatttag acatatatca atattgatgg ttcctgagcc acaaaataat
     5941 acagcggtat gtttttccaa attcccatga gcaactctga ccaaatcgtc ccgaagttgt
     6001 ttcatcatac ctgcgaattc tttctcgcga ggacaaatat ccggaacaac ttgtgccatt
     6061 tttacactgt cagtagtagt ggcaggccca ggatttaata atatttttct ttctattttc
     6121 atcgaatata tttattttaa aaaatccata aaatgctcct tattctctat aggagtagtc
     6181 gtgggacgtc ccaaattctc ccgagaatct attttaacct ttatttccaa caaaacagga
     6241 ccacataact ttggaagctg cttcattgct tcttcaattt caacttttgt acaaacagta
     6301 taagtatgct tatatccgct cccccggaca atagccggaa tatctaaact aaatcctaaa
     6361 gtaggctgtc ctcctacaga ctcgtgagca ccattgttaa acaaaatatg ataatagttt
     6421 ttaggagata aatcgccaat gttactaatt gcccctaaat gcataataaa tgctccatca
     6481 ccatccaagc aataaacagg tctatcttgc tttgctatag caatacccaa agagattgat
     6541 gaactatgtc ccatagagcc taccgtgaga aaatcatgtt catgaccttg ctctttcatt
     6601 tctcgatatt caaataactc acgagaaagc ttgccagtag tagaaacgac cactgaattt
     6661 tcaggcagat aatccacaac tatttgcaaa gcatcctcac gagataaagg ataattacat
     6721 ccgaactctt tttgaagttt atatttgcca aaaacatctt tccgaataat tattgcatga
     6781 ggaatattct tagtttttgc tgattgtatg atatcatgga gcctgaataa atgcatcatt
     6841 ctcatttgaa tcaagaatta tataaggaat ccgcattgct ttcaacaaat ctaaagttac
     6901 ctcaccctgt tttttatgct gaggttcatc ttttgttccc ggttcaccac gccagccaat
     6961 catcaaaagc attggaaaac tgtatacttg ttcatctgca agagacagca gaggattaac
     7021 agtattaccc aagccggaat tttgcatata aaccacagga accttacctg atgccatata
     7081 ataacctgaa gcaattccta cagccgcacc ttcattagca gctatgatat gtttctcacg
     7141 tgaagtatgg tctgtgatat aggcacaaat attttttagt aatgagtctg gaactcctgt
     7201 aaaaaaatca acgtcatgac tcagaaacgt ttcataaact ttttctacgc ttaacataat
     7261 gatattcctc tttttattta gtacctggaa tcagttccaa tatttctttt atgggcatac
     7321 acagttcgcg cacctctaaa gcacgttcat tctctaatat tatctttgcg acattcatca
     7381 tagcaggata agcggcacga agcatatgat tagcataaat aattatattc acaccccaat
     7441 cacacaattc agactcataa atatgatcat atgtagtagg cacaaccacg ataggtacat
     7501 gagcatactg ttttcgaaac gccaaacaaa attcttttat atcttcaccc gacttatttt
     7561 tgctatgtat cataataccg tccgctcccg cttggacata tgcaaaagct ctctctaaag
     7621 catcacttac cggctttccc gctataaggc tctcaatacg agcgataatc ataaaatcat
     7681 cagtaatctg agatgccttt cctgctttga tcttattaca gaaaccttcg attgtatctt
     7741 gagtttgaat aacatctgta ccaaacaatg aattcttttt taatccaact ttatcttcaa
     7801 ttattatagc tgaaattcca tgacgttcta aagtgcgtac tgtaaatacg aaatgttcaa
     7861 ttttaccacc tgtatctcca tcaaaaataa taggtttagt agtacactcc agaatattat
     7921 tcaaatcttg caatcgggta gttaaatcaa ccgcctcaat atcaggttta cctttactgg
     7981 ttgaatccgt aaggctacta gaccacattc cgtcaaatac ttccctctta tcccctttta
     8041 atatttcctg attttcaatt atcaagccac atagtccatc atgagccttc caaaatacga
     8101 actacgggtt tggcatttat caaacgacga agtgatttta aacgtacatc aggggttgta
     8161 cctatagcct taatatcttt atccaaagaa gatgaattaa ttcccaaagt atatggaatt
     8221 tcgataacct ttcctccctg ttcattcatc acttcaaata cgcgcacacg ttcttcacgt
     8281 aaaggcccgg ttttccagtc gtcaccatga attatatagt caggtttaat gcgtttgaga
     8341 ttctcaacat agctccattc ttcttgagga acaactttac atacgccttt aatattctga
     8401 actacctctt ttcgttgttc ataggtcaga taaggaaggc gtttatgctc cgcaatagct
     8461 ttatctgtaa gaagaccaat tataacatca ccgtatttag tagcctcatt aataatgcgg
     8521 ataagtcctg gatgcataat atccgcagtc atcccaatat aaactgtctt actcataatt
     8581 tgatatatta ttttaattaa caatacggaa caatatattt ctctgcatat tccaaatctg
     8641 atatgtcatc gatttcatac catttcagcc cttctacttt atgcacataa acaggagatt
     8701 gagaacaaga tattcgtagt aattcatact catatcccaa attgggttgt tcatcaacaa
     8761 tactcgcata atcagcacac attattttgt aaaataaccg gatagtttat ggatgccgac
     8821 caattcgcct ttagcgttta gtttattctt attgacagaa catgaagaaa ggcgaaaatt
     8881 atcatcatgt tccacataat actgatcttg aaactttgtc actggagtta ttagcattgc
     8941 atctgccgca ggacactcca ataagctcat tattgcttgt ttctcaaaaa tcaaatctga
     9001 ctctaacaat aaaaaatcat cattgcccag aatctcccgc gtattatata aagtatacat
     9061 actatttgtt tcagcataac gaggactaaa acaggtttca agcataggat agtctgtctt
     9121 caattcttca taaacttctt gtttatatcc tgtaccgatt acaattcgct caatgtcaca
     9181 tgataacaaa gtatcaatag aacgaactat cattggaata cctcccactt tgacgaaccc
     9241 tttaggtatc aattctgtat attggccaaa acgggttatg cccgcagcca ttatcatagc
     9301 tgtacgtatc attcgtttaa taatatagta agtgaattta attgatgtaa gaatgttgta
     9361 aacgacgttt tagcatcatt tatcctgttc tatctcctta tttttcagtt cttttctcaa
     9421 gctagccagc agacttttgc caaaaaacac ccacacgaga gtaccagata cggacaggaa
     9481 cacaaataat aaaatataaa ttttgagtcc catacctgaa ggtttcaaag gtacaacggc
     9541 aggctcaact actgcaaaga ctggcttttc ctcctgtact ttggctctgg atacctgcaa
     9601 ctgattagca acctgactat atatctgata agccaaactc atgtcgttct gtaaacgctc
     9661 ctgctcagca cgtacacttt gaagaaccac attatcatgg gcgtctacat aatccgcata
     9721 ttttctttga gcagcataat attcctgctg acgttcttta aacaaccgtt ccaaatacgc
     9781 acagtcttct tttacttttg aagttcgata cccaataata tattcctgta atttatgaac
     9841 gacagaatct gctataaccg cagtgatctg cggattttgt aaggtgaccg taatgctcgt
     9901 tatggcggtt ttcttatcaa tggatgcact aatcttcttt ttaagaaaat taatcttctc
     9961 atttacttct ttcgtcaatt cgatagttcc ttgccgccct ccactggcag gaaccgtatc
    10021 ttctccgaat aatgatttaa ctcctcctat tactatgccc ggaaaaccta taagataatc
    10081 ccaccaagga gatgactctt catcgagata agaccccaaa gtcattttat catccttttt
    10141 agaaacggag acttccattt ctaaaagttc caataaaaaa ggagttgaag aaacaatatc
    10201 tgctgaaaga gaagcgttca aggcatctgt gctttcccct attagagccc catctcccaa
    10261 aaacgaggca gcaagtccgg ctaaaccatt acttcccttc gcattaccca tttcaggaga
    10321 aagggtaacc tttactgtat attgcttggg aatgctcaat gccaccacta tagcaattat
    10381 tactcccact ccagcaagct ttgcatagta ctccacgaac agtaataatc ttataaaaaa
    10441 tagccatcaa gtctatttcc atttcatcat ctttcctttt atccacttca gaaaacggtt
    10501 cttgataaga ttgcttttca atcataatag gtcatttatt tctttatcaa attagcaata
    10561 gaagcaatca tcattcccaa agaactgaag gaagtagcat aacctaaaat attagctatg
    10621 ttccctttct tcttagcctt accaggcaca ataatctcac accccggctc aatctgtttc
    10681 ttaccactac ccttaacctt cgtcacctga ccattcatgt aaacaatgaa cttcttactc
    10741 ttccttgcat tatcagaaca gccaccggcc tgattcaggt aataatccac attctttccc
    10801 ttcatataag aaaccgtatt cgaaccatga cagcaccatt gatagttaca gtattagtat
    10861 tcttaggtat ggagatcaca tcaccttcac gtaagacaag atcggcatta cttttaggat
    10921 tgctcaaggc tttttccaaa tctattccaa ccgtaaaagt atcttcaaca cgaataccca
    10981 aagagtcaat catggcttcg cccaattgcc tgctcataag gcgaattaca tcacccatac
    11041 gtttcttttc actagcgtta gccacacggg tcagtttcgc accacgcaga taggcataat
    11101 tggtcggacc accggcttta ttcactaaat cggaaagacg ttcctcacgg ctggtcatgg
    11161 cgtaatttcc tccgaaaagg atttcacctt caatggctac attctgttgt gcctgatagc
    11221 ccggactgcg acggacataa acctgatcat aaggctcaag gataaaaccg ggctgaccat
    11281 ctattacaaa accatccttt aaagagaagg tatacatctg accaatcgta tcattatccg
    11341 cagtactacg aggattcttg attcgtctcg atatatcaat acggacagta gaggcggctt
    11401 ctttcaagcc accggcctga atgatcagat cctcaagtgt catgttatcc gcataaggat
    11461 aggaatcagg gtgggcaacc tcaccgtgaa ctgtgacatt accccggtct tccaggtcat
    11521 ggatacttgg aatgtagagg atgtcattct tcattagggc aaggtttggg gaagtgccgt
    11581 ccatgataga cttaatgtct atctgaacaa cttcactggt caggtcttca cgctggcgat
    11641 agaggacggc acgattcagg aaagcgtcac cggtcagacc ctgagcttca tggacaagtt
    11701 cgcggatcgt gttcagttta ccgctgagcc tggtagatac cgggacgata gacagcgcca
    11761 cggatttcca gtttgtttgt gaagcggtta aggatggctt cggcggttac tacgtcaccg
    11821 ttacgcattt tataaatgtt gtaatctata tctttgactg tgttgacttc gtattcctca
    11881 ccattctgac ggacaacacg taatgaacgg gtgtaggcat cagccttcaa agccgccggc
    11941 atatttaatg agagtagcaa ggttctcgtc tttcttcatt tcaaaacgca taggacgttt
    12001 taccttgccg ctaatcttta ccaatacatc ataggcagga acaatcacaa cgtcaccttc
    12061 ctgtaggcgg atgtcatcct gtgtgttgcc tttcataatg aattcgtaga cgtcgatggt
    12121 ggcaatattc tttccgttgc gtaccaactg aacgtttcgg aggctaccga tatcactcac
    12181 accgcctgca cgataaagcg catggaagac ggtagagaag gaagaaaggg cgtaggtacc
    12241 gggctgtacg acttctccca tcacattaat ctgaatagta cggatattac ctaacgtcag
    12301 acggatgtcg gaagtaggat cggtagtatt attcagaccg ttatatattt tattcagggc
    12361 gttcttcaga tagtcattgg cggcagagac tgtcataccg ctaaggttga cagggccgat
    12421 cttctgaatg ttgatagtac cttcaggaga gatttgctgg cggatcgtgt tctggctcgc
    12481 accccagata tcaatgatga cttcatcacc gggaccaaga cggtaattgg caggagtggc
    12541 aaggttgaca ctaggctcga acgtcaggtt gcgggtattg aagatgttac gtccgaagac
    12601 ctgatcacca cgggcaaggt cctgagtagt cggatgatcc tccagcatat cggaagtatt
    12661 cttcttagtc tcttcacgca ggcgggattc gttgatgtcc gtgcccgttg atttcgaggt
    12721 atttacattg ttctgctgct cgtatagctg cttcacacgc attgcctgtt ctttggttac
    12781 acccttacgg gctagttcgg aagcaagctg cttctgttcc ttgccttggc ggatgccgtc
    12841 ttttacatat tccagtacct gtgagtcact catggactga gccataagcg agccacttcc
    12901 cagcatcaaa caaaatagta gaatgctaaa aagtcgttgt attttcattg acaaataaaa
    12961 aagtttcagt tgatttcaca cagttcctgc atcccatgac agacggcaga taactgttgc
    13021 ttaagaagag aagggggaag aacatcgaga agagacagag aacgggtcaa aacagcctgt
    13081 tttctttctt cgtcttccgg attggcgtac atcgacacat tatatccctg aaggatggcc
    13141 aaacacaggg tagcatcctg ctccggtgtc tccccccgtt gagaatataa atcgttaatc
    13201 ttttcgtgga tggatcgttg taatgctgaa agatcatcca aatacacgca gcctgcactc
    13261 cccccaccag gaagcagcat acgtaccaaa cttaataaac cctctatatt ttcttgtaaa
    13321 ataatagcat ccatatccct tgccttaaac agccgccata atcggctcta cataaccgac
    13381 aggcatatca acacaggcgc atcccagcat attcaagcga acagcaatct tacttttacc
    13441 atccacattg accagttcgc caacaagacc cgtcaacgga cctttgatca cgcgaacctt
    13501 ttcgccacga gccaaaggag aactgttcat gcttatcgat tcttccgaat aatcaagcat
    13561 gaaacggaaa cgagccatct gctcgtcagg aattacagca ggactactct cgccgcgcat
    13621 caccatgtaa cggctgacag tagaaaaact caggacttcc atgcgttcct tagggtcaac
    13681 gtgtacgaag accatcatag gaagcaagac ggaggtgacc agcttgcgac ggtcgctcca
    13741 ttggtggaat tcctgttgaa cgggaacgaa attctcgata cccatcttgt ccagatgctc
    13801 ggaaaccttc ttttcatggt gcatccgaac caaagcaaca taccagcgtt ttgagtgtgc
    13861 tacgccttcc cctgtcccat taataggccc agcatttagt gatttctttt ttcttaaaat
    13921 catatttttt taccccatgt ttatccgtta cttcttaggt aacgaacaag catagggcaa
    13981 gcagaaaagg gaactttttt caacgaaaac atcagaagag gactggtatt caggaaataa
    14041 agcagaagtg aaggtgtttt tcatgaattg gaataaaaaa aagacataac acggatattg
    14101 tcattttccg cctgttatgc ctgcatttga ttcattttcc gaaattaatt tcatttttgt
    14161 ttgcgtattt tcataaatat gtccatcttt gcgccatgaa tcattccgtt acctaagaag
    14221 taacgcacac cgataaacac tgtatatcaa gcttctaaat cagatacact gacctactcc
    14281 gcaccgcttt acgtaagaca aattcatccg gt
//
