LOCUS       gnlProkkaGOIILHAI_1    14313 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GOIILHAI_1.
ACCESSION   gnlProkkaGOIILHAI_1
VERSION     gnlProkkaGOIILHAI_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:52:05
            Original ID  :: gnl|Prokka|GOIILHAI_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 5996510
            Orig. end    :: 6010823
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14313
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9313]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9313
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14313
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14313
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             394..972
                     /locus_tag="ctg1_7345"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPVVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             1411..1923
                     /locus_tag="ctg1_7346"
                     /transl_table=11
                     /translation="MLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQKQLASELARKGVTK
                     EQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLEDHPTTQDLARGDQVF
                     GRNIFNTRNLTFEPSVNLATPANYRLIPVMKSSLISGVRARTRSASKSLLKVLSTFRRS
                     ALSTLAV"
     CDS             1920..2144
                     /locus_tag="ctg1_7347"
                     /transl_table=11
                     /translation="MTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNIRTIQINV
                     MGEVVQPMHLRPFFLLYRLPCALSCRRCE"
     CDS             2137..3780
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 71.1;
                     E-value: 1.1e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_7348"
                     /transl_table=11
                     /translation="MSDIGSLRNVQLVRNGKNIATIDVYEFIMKGNTQDDIRLQEGDVV
                     IVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGFEADAYTRSLRVVRQNGEEYE
                     VNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAVYRPGIYQLSGKLNTIRELVH
                     EAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGTSPNLALMKNDILYIPSIHDL
                     EDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEAASTVRIDISRRIKNPRSTAD
                     NDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPGYQAQQNVAIEGEILFGGNYA
                     MTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMIDS
                     LGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTVSY
                     MKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAKK
                     KGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3791..4339
                     /locus_tag="ctg1_7349"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVLPVEGGKELSN"
     CDS             4539..4937
                     /locus_tag="ctg1_7350"
                     /transl_table=11
                     /translation="MERLFKERQQEYYAAQRKYADYVDAHDNVVLQSVRAEQERLQNDM
                     SLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGLKIYILLFVFLSVSG
                     TLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7351"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.8e-13, bitscore:
                     49.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGIGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGYFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..7042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7352"
                     /sec_met_domain="CTP_transf_like (E-value: 1.2e-10,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.2e-118, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-60, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             7059..8051
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 48.9;
                     E-value: 7e-15)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7353"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.7e-18, bitscore:
                     64.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-15, bitscore:
                     54.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGADISILILFVQKLKLKKQ"
     CDS             8048..8182
                     /locus_tag="ctg1_7354"
                     /transl_table=11
                     /translation="MKQLPKLCGPVLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8192..9313
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg1_7355_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_7355"
                     /sec_met_domain="Aminotran_5 (E-value: 9e-29, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8282..9289
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_7355_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg1_7355_Aminotran_5.1"
                     /locus_tag="ctg1_7355"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9310..9453
                     /locus_tag="ctg1_7356"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9692..9961
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7357"
                     /sec_met_domain="Polysacc_synt (E-value: 6.6e-06, bitscore:
                     24.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKIELKRILPLSFILIFLSQYYSMVYCFFRLL"
     CDS             9958..10374
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7358"
                     /sec_met_domain="Polysacc_synt (E-value: 1.4e-06, bitscore:
                     26.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIADFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQS
                     KISLGAAFISGVIGIWMAYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSF
                     ERLFNFGSKLLISSLINTVYRNLYTIVIGKSFLL"
     CDS             11091..11351
                     /locus_tag="ctg1_7359"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKIVLNIIKYMLKFMILLVFQNIKNIFMA"
     CDS             11426..12349
                     /locus_tag="ctg1_7360"
                     /transl_table=11
                     /translation="MLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDY
                     HMGDHSYDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNN
                     CNVIKREISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFN
                     AALILKLHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLV
                     NKPVIFNFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRR
                     HISLLMNQFQDDNSTKRICDIFLNEI"
     CDS             12358..13131
                     /locus_tag="ctg1_7361"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKILNNEEYLYYW"
     CDS             13106..14080
                     /locus_tag="ctg1_7362"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKM"
ORIGIN
        1 gtgaaccgga tgaatttgtc ttacgtaaag cggtgcggag taggtcagtg tatctgattt
       61 agaagcttga tatacagtgt ttatcggtgt gcgttacttc ttaggtaacg gaatgattca
      121 tggcgcaaag atggacatat ttatgaaaat acgcaaacaa aaatgaaatt aatttcggaa
      181 aatgaatcaa atgcaggcat aacaggcgga aaatgacaat atccgtgtta tgtctttttt
      241 tattccaatt catgaaaaac accttcactt ctgctttatt tcctgaatac cagtcctctt
      301 ctgatgtttt cgttgaaaaa agttcccttt ttctgcttgc cctatgcttg ttcgttacct
      361 aagaagtaac ggataaacat ggggtaaaaa aatatgattt taagaaaaaa gaaatcacta
      421 aatgctgggc ctattaatgg gacaggggaa ggcgtagcac actcaaaacg ctggtatgtt
      481 gctttggttc ggatgcacca tgaaaagaag gtttccgagc atctggacaa gatgggtatc
      541 gagaatttcg ttcccgttca acaggaattc caccaatgga gcgaccgtcg caagctggtc
      601 acctccgtct tgcttcctat gatggtcttc gtacacgttg accctaagga acgcatggaa
      661 gtcctgagtt tttctactgt cagccgttac atggtgatgc gcggcgagag tagtcctgtt
      721 gtaattcctg acgagcagat ggctcgtttc cgtttcatgc ttgattattc ggaagaatcg
      781 ataagcatga acagttctcc tttggctcgt ggcgaaaagg ttcgcgtgat caaaggtccg
      841 ttgacgggtc ttgttggcga actggtcaat gtggatggta aaagtaagat tgctgttcgc
      901 ttgaatatgc tgggatgcgc ctgtgttgat atgcctgtcg gttatgtaga gccgattatg
      961 gcggctgttt aaggcaaggg atatggatgc tattatttta caagaaaata tagagggttt
     1021 attaagtttg gtacgtatgc tgcttcctgg tggggggagt gcaggctgcg tgtatttgga
     1081 tgatctttca gcattacaac gatccatcca cgaaaagatt aacgatttat attctcaacg
     1141 ggggagacac cggagcagga tgctaccctg tgtttggcca tccttcaggg atataatgtg
     1201 tcgatgtacg ccaatccgga agacgaagaa agaaaacagg ctgttttgac ccgttctctg
     1261 tctcttctcg atgttcttcc cccttctctt cttaagcaac agttatctgc cgtctgtcat
     1321 gggatgcagg aactgtgtga aatcaactga aactttttta tttgtcaatg aaaatacaac
     1381 gactttttta gcattctact attttgtttg atgctgggaa gtggctcgct tatggctcag
     1441 tccatgagtg actcacaggt actggaatat gtaaaagacg gcatccgcca aggcaaggaa
     1501 cagaagcagc ttgcttccga actagcccgt aagggtgtaa ccaaagaaca ggcaatgcgt
     1561 gtgaagcagc tatacgagca gcagaacaat gtaaatacct cgaaatcaac gggcacggac
     1621 atcaacgaat cccgcctgcg tgaagagact aagaagaata cttccgatat gctggaggat
     1681 catccgacta ctcaggacct tgcccgtggt gatcaggtct tcggacgtaa catcttcaat
     1741 acccgcaacc tgacgttcga gcctagtgtc aaccttgcca ctcctgccaa ttaccgtctt
     1801 attccggtga tgaagtcatc attgatatct ggggtgcgag ccagaacacg atccgccagc
     1861 aaatctctcc tgaaggtact atcaacattc agaagatcgg ccctgtcaac cttagcggta
     1921 tgacagtctc tgccgccaat gactatctga agaacgccct gaataaaata tataacggtc
     1981 tgaataatac taccgatcct acttccgaca tccgtctgac gttaggtaat atccgtacta
     2041 ttcagattaa tgtgatggga gaagtcgtac agcccatgca cctacgccct ttcttccttc
     2101 tctaccgtct tccatgcgct ttatcgtgca ggcggtgtga gtgatatcgg tagcctccga
     2161 aacgttcagt tggtacgcaa cggaaagaat attgccacca tcgacgtcta cgaattcatt
     2221 atgaaaggca acacacagga tgacatccgc ctacaggaag gtgacgttgt gattgttcct
     2281 gcctatgatg tattggtaaa gattagcggc aaggtaaaac gtcctatgcg ttttgaaatg
     2341 aagaaagacg agaaccttgc tactctcatt aaatatgccg gcggctttga agctgatgcc
     2401 tacacccgtt cattacgtgt tgtccgtcag aatggtgagg aatacgaagt caacacagtc
     2461 aaagatatag attacaacat ttataaaatg cgtaacggtg acgtagtaac cgccgaagcc
     2521 atccttaacc gcttcacaaa caaactggaa atccgtggcg ctgtctatcg tcccggtatc
     2581 taccagctca gcggtaaact gaacacgatc cgcgaacttg tccatgaagc tcagggtctg
     2641 accggtgacg ctttcctgaa tcgtgccgtc ctctatcgcc agcgtgaaga cctgaccagt
     2701 gaagttgttc agatagacat taagtctatc atggacggca cttccccaaa ccttgcccta
     2761 atgaagaatg acatcctcta cattccaagt atccatgacc tggaagaccg gggtaatgtc
     2821 acagttcacg gtgaggttgc ccaccctgat tcctatcctt atgcggataa catgacactt
     2881 gaggatctga tcattcaggc cggtggcttg aaagaagccg cctctactgt ccgtattgat
     2941 atatcgagac gaatcaagaa tcctcgtagt actgcggata atgatacgat tggtcagatg
     3001 tataccttct ctttaaagga tggttttgta atagatggtc agcccggttt tatccttgag
     3061 ccttatgatc aggtttatgt ccgtcgcagt ccgggctatc aggcacaaca gaatgtagcc
     3121 attgaaggtg aaatcctttt cggaggaaat tacgccatga ccagccgtga ggaacgtctt
     3181 tccgatttag tgaataaagc cggcggtccg accaattatg cctatctgcg tggtgcgaaa
     3241 ctgacccgtg tggctaacgc tagtgaaaag aaacgtatgg gtgatgtaat tcgccttatg
     3301 agcaggcaat tgggcgaagc catgattgac tctttgggta ttcgtgttga agatactttt
     3361 acggttggaa tagatttgga aaaagccttg agcaatccta aaagtaatgc cgatcttgtc
     3421 ttacgtgaag gtgatgtgat ctccatacct aagaatacta atactgtaac tatcaatggt
     3481 gctgtcatgg ttccgaatac ggtttcttat atgaagggaa agaatgtgga ttattacctg
     3541 aatcaggccg gtggctgttc tgataatgca aggaagagta agaagttcat tgtttacatg
     3601 aatggtcagg tgacgaaggt taagggtagt ggtaagaaac agattgagcc ggggtgtgag
     3661 attattgtgc ctggtaaggc taagaagaaa gggaacatag ctaatatttt aggttatgct
     3721 acttccttca gttctttggg aatgatgatt gcttctattg ctaatttgat aaagaaataa
     3781 atgacctatt atgattgaaa agcaatctta tcaagaaccg ttttctgaag tggataaaag
     3841 gaaagatgat gaaatggaaa tagacttgat ggctattttt tataagatta ttactgttcg
     3901 tggagtacta tgcaaagctg ctggagtggg agtaataatt gctatagtgg tggcattgag
     3961 cattcccaag caatatacag taaaggttac cctttctcct gaaatgggta atgcgaaggg
     4021 aagtaatggt ttagccggac ttgctgcctc gtttttggga gatggggctc taatagggga
     4081 aagcacagat gccttgaacg cttctctttc agcagatatt gtttcttcaa ctcctttttt
     4141 attggaactt ttagaaatgg aagtctccgt ttctaaaaag gatgataaaa tgactttggg
     4201 gtcttatctc gatgaagagt catctccttg gtgggattat cttataggtt ttccgggcat
     4261 agtaatagga ggagttaaat cattattcgg agaagatacg gttctgccag tggagggcgg
     4321 caaggaacta tcgaattgac gaaagaagta aatgagaaga ttaattttct taaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgttttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttacatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcataggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtga cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaataact ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 acttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca acccctgatg tacgtttaaa
     6181 atcacttcgt cgtttgataa atgccaaacc cgtagttcgt attttggaag ctcatgatgg
     6241 actatgtggc ttgataattg aaaatcagga aatattaaaa ggggataaga gggaagtatt
     6301 tgacggaatg tggtctagta gccttacgga ttcaaccagt aaaggtaaac ctgatattga
     6361 ggcggttgat ttaactaccc gattgcaaga tttgaataat attctggagt gtactactaa
     6421 acctattatt tttgatggag atacaggtgg taaaattgaa catttcgtat ttacagtacg
     6481 cactttagaa cgtcatggaa tttcagctat aataattgaa gataaagttg gattaaaaaa
     6541 gaattcattg tttggtacag atgttattca aactcaagat acaatcgaag gtttctgtaa
     6601 taagatcaaa gcaggaaagg catctcagat tactgatgat tttatgatta tcgctcgtat
     6661 tgagagcctt atagcgggaa agccggtaag tgatgcttta gagagagctt ttgcatatgt
     6721 ccaagcggga gcggacggta ttatgataca tagcaaaaat aagtcgggtg aagatataaa
     6781 agaattttgt ttggcgtttc gaaaacagta tgctcatgta cctatcgtgg ttgtgcctac
     6841 tacatatgat catatttatg agtctgaatt gtgtgattgg ggtgtgaata taattattta
     6901 tgctaatcat atgcttcgtg ccgcttatcc tgctatgatg aatgtcgcaa agataatatt
     6961 agagaatgaa cgtgctttag aggtgcgcga actgtgtatg cccataaaag aaatattgga
     7021 actgattcca ggtactaaat aaaaagagga atatcattat gttaagcgta gaaaaagttt
     7081 atgaaacgtt tctgagtcat gacgttgatt tttttacagg agttccagac tcattactaa
     7141 aaaatatttg tgcctatatc acagaccata cttcacgtga gaaacatatc atagctgcta
     7201 atgaaggtgc ggctgtagga attgcttcag gttattatat ggcatcaggt aaggttcctg
     7261 tggtttatat gcaaaattcc ggcttgggta atactgttaa tcctctgctg tctcttgcag
     7321 atgaacaagt atacagtttt ccaatgcttt tgatgattgg ctggcgtggt gaaccgggaa
     7381 caaaagatga acctcagcat aaaaaacagg gtgaggtaac tttagatttg ttgaaagcaa
     7441 tgcggattcc ttatataatt cttgattcaa atgagaatga tgcatttatt cagctccatg
     7501 atatcataca atcagcaaaa actaagaata ttcctcatgc aataattatt cggaaagatg
     7561 tttttggcaa atataaactt caaaaagagt tcggatgtaa ttatccttta tctcgtgagg
     7621 atgctttgca aatagttgtg gattatctgc ctgaaaattc agtggtcgtt tctactactg
     7681 gcaagctttc tcgtgagtta tttgaatatc gagaaatgaa agagcaaggt catgaacatg
     7741 attttctcac ggtaggctct atgggacata gttcatcaat ctctttgggt attgctatag
     7801 caaagcaaga tagacctgtt tattgcttgg atggtgatgg agcatttatt atgcatttag
     7861 gggcaattag taacattggc gatttatctc ctaaaaacta ttatcatatt ttgtttaaca
     7921 atggtgctca cgagtctgta ggaggacagc ctactttagg atttagttta gatattccgg
     7981 ctattgtccg gggagcggat ataagcatac ttatactgtt tgtacaaaag ttgaaattga
     8041 agaagcaatg aagcagcttc caaagttatg tggtcctgtt ttgttggaaa taaaggttaa
     8101 aatagattct cgggagaatt tgggacgtcc cacgactact cctatagaga ataaggagca
     8161 ttttatggat tttttaaaat aaatatattc gatgaaaata gaaagaaaaa tattattaaa
     8221 tcctgggcct gccactacta ctgacagtgt aaaaatggca caagttgttc cggatatttg
     8281 tcctcgcgag aaagaattcg caggtatgat gaaacaactt cgggacgatt tggtcagagt
     8341 tgctcatggg aatttggaaa aacataccgc tgtattattt tgtggctcag gaaccatcaa
     8401 tattgatata tgtctaaatt ctcttcttcc tgaagacaaa agggtgctta tagtgaataa
     8461 tggggcatat agtacccgtg ctgtagaagt gtgtcaatat tatggtttgc ctcatattaa
     8521 tttggaattt tccgtttacg aacgtcctga tttatcggtg gtggaaaatg tgttgcaaga
     8581 aaatcctgat atagctatgg tttatactac tcatcacgag acgggtacag gaattctgaa
     8641 ccctattcgc gagatgggcg ctatagctca taaatatcag gctaaatttg tcgtcgatac
     8701 tacttcttct ttgggcatga ttccttttga tatagagaaa gataatgtgg atttttgtat
     8761 ggcatctgct caaaaaggac ttcaagcgat gacaggtctt tcttttatta taggcaatga
     8821 ggaacagatt aagttttcaa aaaaatatcc caagcgttct tactattgta atctttattt
     8881 gcagtatgag aattttgaga gaacaggtga aatgcatttt actccaccgg tacaaactat
     8941 ttacgccact cgtcaggcat taaatgaata ttttgaagtg ggtgaagaag ctaagtttgc
     9001 ccgtcacaaa agagtttttg aggctattca ttcaggtata aatgaaattg gtcttaaaag
     9061 tgtaataaag cgtgaatggc agtcaggact ggttgtctca gttcaatacc cagaagatcc
     9121 caactgggat tttgagaaaa tacatgatta ttgttatgag cgtggattta cgatttatcc
     9181 aggtaagata tcaactgagg atacttttag aatctgtgct ttaggagaga tagaagtaga
     9241 tgatattgag aacttcttta aagtactaaa agctgcatta aatcattata acgtcacatt
     9301 accgatgtca tgattgcaga aatattattg aagattcgtc atttttattt ttcccttcgt
     9361 ggtatacact tccatccgga aagtgttatt tctggagtgc ctattcgtag ctttcgctta
     9421 gtaggcaaat atggcaatat taatttgagg tgatgcatta ggagttcttt attcttataa
     9481 aaaggcatcg gtagttatag gagataatgt ttgtgtaggg taatttgctt ttagtgggag
     9541 agaccatatt agaattgcgg taaggggcga agaagataat aaccaattag tgagaatatt
     9601 ggaaaaatat aattgatatc ggtaaatgta gttgttttta tactgtattt aagtaatgga
     9661 aaatctaaag cagaaaactg tatcaggaat aatgtggagc gctatagaac gtttctcttt
     9721 acaaggagta cagtttataa ttcaaataat attagctcgt ttgttactac catcggatta
     9781 tggtatgatc gggatgttag ctatttttct tcaagtcgct caagtattta tagatagcgg
     9841 ttttacaaat gctttaatcc agaaaaagat agaactgaag aggattttgc cactgtcttt
     9901 tattttaata ttcttgtcgc agtattattc tatggtatat tgtttttttc ggcttctttg
     9961 attgcagact tttataatat gccgacttta gttcttgtaa ttcgttttat agcattgtcg
    10021 ttgataataa atgctttatc ggctattcac agaacgaaat taattatttc tgtaaacttt
    10081 aaaactcaat ctaaaatttc attaggtgca gcttttatat caggcgtgat tggaatatgg
    10141 atggcttatg tcggttgcgg ggtttgggct ttagtttggc aaactctctt aaatagtata
    10201 attttgacaa ttttgtttta ctgtttagtt cattggaaac ctttacatac tttctccaaa
    10261 agttcttttg aaagattatt caatttcgga tctaaattat tgatctcaag tcttatcaat
    10321 acagtatatc gtaatctgta taccattgta ataggaaaaa gttttctgtt gtagagcttg
    10381 gttactatac aagagcagaa caatttgcta tttttccttc caataattta aatgctttag
    10441 tttctagagt agcgtatcct attttaagtt ccattcaaga tgatgataaa tgtttaacaa
    10501 acgcatatcg aaattatatc agattatcct catatataat ttttccttta atggtaggtt
    10561 tacttgtttt ggctaatcct attattagtc tattgttaac agataaatgg tctggggttg
    10621 ttattctttt acagatatta tgtttggatt ggatgtttga tcatttgagc caaattaatt
    10681 tgaatttatt atgggttaaa ggaagatctg atctgtcgtt acgtcttgaa ataataaaaa
    10741 gacgattgct atattcattc ttttgtgtca attccatttg ggcttgaggt gatgtgttgg
    10801 ggtagagtta tttactctct gatagcgaca tatttgaata catattatac taattctctt
    10861 attgatttga ccttaaagtt gcaagttaaa gatgtatttc caagtttaat actctctttc
    10921 ataatggggg ggatcgtttt tatatgtatt tctttctttg aaactgatat agtaaaaatt
    10981 gtgattggat gtattactgg gatgtccttc tatattttac tttcttttct ttttaagcta
    11041 gattcttttt tttgtatttt taacattgat cattaaaact aaaaacatag atgaaaatat
    11101 taaaaaagat ttttcaagta atagtaaaga taattaacca ttgtgtgcca gttgatagta
    11161 gatcattgta ttttattcct catcctaatt gtagaacaga taaatatgat attataaatt
    11221 attcgtcaga taatgttctc gttctgttaa attatttgct aaaaaagata gtgctgaata
    11281 ttataaaata tatgttgaaa tttatgattc ttctcgtatt tcagaatatc aagaatatat
    11341 ttatggcata aatcctaata ttaggtgtac ttttttatgt gcatgtgttg gacgtttttt
    11401 ctttaataaa gtatctttta aggatatgtt gtatgccttt ttttgttttt gtagagcaag
    11461 taaatgtttt acagctactt tttattatga tttttcattt aaaaaacgct ctcaacagat
    11521 tatttgtttg gggtattata ctccattcaa agatgattat catatgggag atcattctta
    11581 tgataaattt cgtaatacaa catgtaactc atttgattac tctattgcta cttcttgttt
    11641 aagtgctaga ataatttcaa tagattgtgg aatctcatat gataaattca aagtcttagg
    11701 atttcccaga aatgatttgt tgatatcgaa aaataattgc aatgttatta aaagagaaat
    11761 ttcgaaattt gcgggatatg atgtaactaa atatatagtt tatactccaa cttttcgtga
    11821 ttatgagact gttactgaag gtaatttgcg ttcaatactc ggatatgttg attgtgattt
    11881 gttgaagtta tcgaaaatac tattgaagtt taatgcggct ttaattctta aattacatcc
    11941 tttgcagaat aaaacagtct taaaaaaaga tttacccaaa ggtatacttg tttttgaaca
    12001 aacatataaa tatggattgt atgatctttt gtcattttca gatggaatga ttactgatta
    12061 tacttctacc tattttgatt ttttattggt aaataagcca gtcatattta atttctacga
    12121 tattgaagaa tatcgtagag taagaggttt ctcatttgag ccaatagaat ttttttgtgc
    12181 aggtgatatt gtttacaatt ataatgaatt gatagatgct gtgatgggac ttctggctgg
    12241 gaaagatatt catgctgaac atcgacgtca tatttcttta ttgatgaatc aatttcaaga
    12301 tgataattca acaaagagaa tatgtgacat atttttaaat gaaatataat aaataaaatg
    12361 aattatgcat ttgtggtgca ggcacgttta ggttctacac gtttgcctgg aaaaatattg
    12421 aaacctttct atggtaatca atcgattctt gacttaatgg ttcataagct ttctgctata
    12481 tcgaatattc cagtaattat tgctacaaca aattctgtta tcaatgaacc tattgaaaag
    12541 aaggcacttg cattaggggt aaagtgcttc agaggtgagg agaatgatgt tttaaaacga
    12601 ttcattgatg ttgctgaata ttttgatata cagggtatat tccgaatatg ttctgataat
    12661 ccatttttag atgtacatgc ggcaaggcaa ttggtcgaaa tagcaatgaa atcttgtaac
    12721 gattatataa gttttgatat tgatggtact ccatcaatta aaactcattt cggtttttgg
    12781 ggagaatttg taacgcttga tgcgctgaag cgagttatag gatttactga tgatttattg
    12841 tatcgtgaac atgttactaa ttatatatat agtcatcctg aactttttaa tattcaatgg
    12901 atttcaggat ctccagtcgt gtcaaaacat cataatattc gactcacgat tgatacgtta
    12961 gaagattttt ctgtagcaca gagaatatat agggatttac aagaaaaaag agtggaaata
    13021 tcgatagaag tgattgtaga ctatgttcga agacatgcag aatacattca actgatgaaa
    13081 caacaaataa aaaaaattct aaataatgaa gaatacttat attattggtg aaatagggca
    13141 gaatcataat ggttctgttg acttggctaa gttgattatt gaattaatct cacgacctgt
    13201 acatgaggat gtttttggta tggatttcat gccaatgaat gctgttaaaa tgactaaaag
    13261 agatttatca gaagaattgg ctgtttctca aatgaatcaa atatatgaca atcctaattc
    13321 ttttgggcgt acttatggtg aacatcgtgc ttttcttgag cttgatgatc aagcgcattt
    13381 tgagatttat aaatatgcta agtcattagg attagatttt atcgagacgt tatgtgccaa
    13441 aggatgtctg tctttgctta aactgttcac accggatagg ctaaaagttg ctagtcgtga
    13501 tttgactaac ttaccattgc ttgaagcatt agcagaaact catattccta ttatattatc
    13561 gacaggaatg gctggtcaaa gagaacttga caatgcatta gatgtgataa cgagatatca
    13621 tagtaatata gctattctac attgtgtatc tcagtatcca actcatccaa ataatttgaa
    13681 tctacgtaca ataacatatt tgaagaagca ttacaataag tttgagatag gtttttctga
    13741 tcatacaata ggtatttctg ctgctacagc tgctgtagcg atgggagcgg aaattataga
    13801 aaagcatgta acaattgatc ggcatatgaa aggaacagac cagcttggct ctttaggtcc
    13861 agatggggtt aatcgtatga ttcgagatat tcgcatagca gagtgttggc ttggtactga
    13921 agatctttat atagaaaaag gggtggagaa gtctaagata aaacttgaac gttctattgc
    13981 cactcgaaaa tatattccag caggtagtat tattcaagag tcggacattc atttactgag
    14041 tcctggtgat ggttataaat ggatagataa aaaaatgtaa ttggtcattt tgctaaacaa
    14101 gatatatcag cgaatgaaat aatatatcct gattttattg aatagatata ttcctactgc
    14161 aacttgtatt acggtataga gtactgcctg ctataagcta agtagtgatt aataaataag
    14221 ggtaaaatac taaaaaaatg aaagagataa agcttatact tacagatatt gatggcgttt
    14281 ggactgatgg cggaatgttt tatgatcaaa cag
//
