LOCUS       gnlProkkaEPGDGCKK_93   17893 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPGDGCKK_93.
ACCESSION   gnlProkkaEPGDGCKK_93
VERSION     gnlProkkaEPGDGCKK_93
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 14:30:02
            Original ID  :: gnl|Prokka|EPGDGCKK_93
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 55061
            Orig. end    :: 72954
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17893
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10597]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10597
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..17893
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17893
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             17..895
                     /locus_tag="ctg66_53"
                     /transl_table=11
                     /translation="MSKKLLYAAQMTAFDKDGNINLDGIRALVRYNIDVNKVDGLYVCG
                     STGEAFMLNTDEKKQVMETVYDEANGAIDLVAQVGSLNLKEAKELAKFATDLGYPKLSA
                     VTPFYYNFTFEQIKDYYNEILKDVDNKLLIYSIPALTGVALTTDQFAELFENPKIIGIK
                     YTNADFYLLERVRNAFPDKLILSGFDEMLLPALALNVDGCIGSTYNLNAPRVREEMDAF
                     EAGDIDKARQLQNISNDMITDLIANDIYPTLKLVMKHMGVDAGYVKKPMSHPTPEMEAG
                     ATAIYEKYFKN"
     CDS             929..1615
                     /locus_tag="ctg66_54"
                     /transl_table=11
                     /translation="MKNTFLNTVKGSLIISCQALPNEPLHSSFIMSRMALAAKEAGAAG
                     IRANSVVDIQAIQDEVDLPLIGLSKIDYPDSPVYITPTIKEMRAVAATGCAVVACDVTG
                     QPRPNGEKLAEIVATMRTEFPDTLLMADTDTIENVKVADKLGFDIIGTTMHGYTPATTG
                     ANIADNDFAYLKEVLQATSRPVIAEGKVDTPEKMKRCLDLGCHAVVVGGTITRPLEIAQ
                     RFISTL"
     CDS             complement(1754..2959)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 123.3; E-value: 1.7e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_55"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.3e-54, bitscore:
                     176.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLDQTNNYRYVIVGGGMAAGYAIKGIRQEDPEGAILVISQEAD
                     VPYERPALSKKLWLDDEFTEENIRIGAENYPNVTFKFKTTVTAINRQDKVITLTDSEQI
                     KYEQLLLATGGEPRQIQGPADPHVLVFRQWSDYRKLRKFSGPNKRVVIIGGGYVGTELA
                     SSLTQNGTKVTMIFPEKALGEGKFPESIRAEYEATFKRNGVTLMSGQFVQSYQRQGDHL
                     TLLTKDSTAIAADTIIVGLGVTPRISLAEDSSLDLADGGVKVNEYLNTSDPAIWSAGDI
                     ASYPDHILGRQRIEHVDHARLSGELVGRNMAGAHMSYQHTPYFYSMIFDISWQAIGNID
                     PKLQLIFDRRTHGSLVYFIDAGKLVGVLVWNVKVNLDDVRALLANAPATDDLVGSIREQ
                     EG"
     CDS             3427..3798
                     /locus_tag="ctg66_56"
                     /transl_table=11
                     /translation="MRLWHEQLIHQLPRQQLLGQHRELAALRGNGWGKNHATVNYVFKY
                     SPYKLHQFHVLVMDEMQLRGYHPNKIWYDPNYRGQFCPPYDHLTPIALTTPIYPEHNAS
                     YLAECVRNLAAKGIIMPTT"
     CDS             complement(3994..4542)
                     /locus_tag="ctg66_57"
                     /transl_table=11
                     /translation="MSKLIAKNVFQLPKMNLLVLTTSAFLLALDVILYKIAIGPAYFQL
                     SFGFLSMACIGYLYGPIWGGLLEMISDILSFNIFGSGAFQIAFLLTAFLGGFIDGLFLY
                     RKSVNWLSVVMTQILVMIFVSLMMDSWLISVLFGTHFKVLLLGRLARVIIQIPLQVIAI
                     FYFIKALEKRHVFDRMRLR"
     CDS             complement(4737..4871)
                     /locus_tag="ctg66_58"
                     /transl_table=11
                     /translation="MIKSILKFCLAAILIVSGVLIGGTVLTAQGIDNLGDKLQDKLHG"
     CDS             complement(4888..5133)
                     /locus_tag="ctg66_59"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             5479..6933
                     /locus_tag="ctg66_60"
                     /transl_table=11
                     /translation="MTEKLTTETGQPWANNEHSQTAGARGPVLMQDYNLLEKLAHFDRE
                     RIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKKTPVILRFSQVAGEKGYPDTV
                     RDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFIHSQKRDPKTNRRTQNMQWDF
                     WAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVNQNGEQFWVKYHFISDQGIKN
                     MTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQILSYKEGLNYKWDIFDVTKVI
                     SHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPGIEPSPDKLLQGRLFSYKDAQ
                     RYRLGANFEDLLVNKPVVPVHNYERDGYMKINNQGAEVNYEPNALHGPEEVPDAALSPD
                     SVRGETRAQPYRYQVDYITQAGDLYRLMSEPEQERLINTIKDALGQVTLPDVKELEIKQ
                     FYEADKNYGTRVANALGMNIADIISD"
     CDS             complement(7091..7528)
                     /locus_tag="ctg66_61"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDPIINKRMVE"
     CDS             complement(7884..8627)
                     /locus_tag="ctg66_62"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDVNGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(8620..9882)
                     /locus_tag="ctg66_63"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENKFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(10001..10597)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_64"
                     /sec_met_domain="AgrB (E-value: 1.1e-34, bitscore: 111.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IGTGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             complement(10965..13079)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     962.9; E-value: 2.4e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg66_65"
                     /transl_table=11
                     /translation="MANFYENDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGKSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAFKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLTDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEAAKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(13470..13703)
                     /locus_tag="ctg66_66"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDCRYVM"
     CDS             complement(14332..14874)
                     /locus_tag="ctg66_67"
                     /transl_table=11
                     /translation="MVMLVFLKQSNFNHVTINEIIAALEPINQRPLKTIGLIRINFTIC
                     HTNLPVIVKGIQSPEDALLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHEIAQAVNGRV
                     PIIFDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHLNDELLIDMQ
                     LAGTKTIEDVKRAKLLR"
     CDS             15103..15639
                     /locus_tag="ctg66_68"
                     /transl_table=11
                     /translation="MLPLLILLVEFVLLIFLGKIRKKIMDYTRSDELYFWGLFLKKSDS
                     RQKMKQIKKKVLQTYRRSSLKNELLFWLEFTVARGCFYGSLMWLWYIVAFGNSIIQIRP
                     AIIGFMIAIPPTIALPQQLYHFWKQQPIWHEQPIEKQAFLLPNEQDHKALFKYHLQSYS
                     LLLLSLVIGWFGTGI"
     CDS             complement(15711..16169)
                     /locus_tag="ctg66_69"
                     /transl_table=11
                     /translation="MTISNNELPEADLTAILETKYKLPDWIGYLTVDGIGKWGISEKIK
                     KGNFELEIGDSKDGEFSFKLKYYVYQVEKGSLSETLTIEIDVTFNKSDFDNWPTYDPAE
                     SFGITLAATLSVAVIISMAPAIAGSASAAGVVAAFVALATKFLTNNKG"
     CDS             complement(16284..16841)
                     /locus_tag="ctg66_70"
                     /transl_table=11
                     /translation="MPKKAKNLTSDEISKLTAAGFSIFPIYEDGGYEVSYFTESQGTKD
                     AYLAAYAARALGFPDGTVIYFAADLDLQDGDIEGTVIAYLQAVRASLTDLGYKTGLYGT
                     RNVCLHAAESMGISNFFVANMSYGWSGNLGFPMPKNWCFDQFVEYTTGSGVDIDQDASS
                     GRDSGTKKFKSTGGVTADEALK"
     CDS             complement(16810..17703)
                     /locus_tag="ctg66_71"
                     /transl_table=11
                     /translation="MQYELKVSPLGEGFGNATRKAVDGFVANLKLNYKGNVAKLIQGAF
                     WCKGISPNDFSTVYSADTIAAVKKLQSDAGITANGTMTTNLMAALFDMSAFVLVQNGDA
                     KIRAMQQWLNANYESYIGIRPCDGIYQRDTNEALIYALQAIEGMSPSEANGYYGNQTIA
                     LTPTVKVGEHGNIVKLIQYGLYVNNYYQSGAFDGYFSTTVANEIVAFRKFMILPDGSLS
                     SASTYSGVADLRVIKGLLTSNGDTGRDSNTFDCATQLTDTSMIQRLYQAGFSIVGRYLT
                     GSVGTGSAEKSQELDI"
     CDS             complement(17806..17892)
                     /locus_tag="ctg66_72"
                     /transl_table=11
                     /translation="MSRTPWKHHLFKLDTYYMYEGISFTQDS"
ORIGIN
        1 aaggagtttt atacttatga gtaaaaaact attatatgca gcacaaatga cagccttcga
       61 caaagacggt aatattaatt tagatggcat ccgtgctctc gttcgctaca acattgacgt
      121 caataaggtt gatggcttgt atgtttgtgg tagtactggt gaagccttca tgctgaatac
      181 tgacgaaaag aaacaagtca tggagaccgt ctatgatgaa gcaaacggtg cgattgactt
      241 agttgcccaa gttggctcac taaatctaaa agaagctaaa gaactcgcta agtttgcgac
      301 tgatcttggc tatccgaaat tatcagccgt aacgcctttc tattacaact ttacttttga
      361 acaaatcaaa gactactaca acgaaatcct taaagatgtt gacaacaaat tattaatcta
      421 ttccatccct gctttaactg gtgttgcctt aacaaccgat caatttgcgg aactctttga
      481 aaatccaaag atcatcggaa tcaagtacac caacgcagac ttttacttac ttgaacgggt
      541 acgcaatgcc tttccagaca aactcatctt atctggattt gacgagatgc ttttgcctgc
      601 ccttgcattg aatgtcgacg gttgcatcgg ctcaacgtat aacttaaatg caccacgtgt
      661 tcgtgaggaa atggacgctt ttgaagctgg cgatattgac aaagcacgtc aactgcaaaa
      721 catcagtaac gatatgatta ctgatctaat tgccaacgac atttatccaa cgcttaaatt
      781 ggtcatgaaa catatgggtg ttgatgccgg ttacgttaag aaaccaatga gccatccaac
      841 ccctgaaatg gaagcaggag ctacggcaat ttacgaaaaa tacttcaaga actaatctaa
      901 tttatactag tagaaagcgg tcttttttat gaaaaataca ttcttaaata cagttaaggg
      961 atcattaatt atctcgtgtc aggcgttacc taatgaacca ctgcatagtt catttattat
     1021 gtcacgaatg gcccttgccg ctaaggaagc tggggccgcg ggtattcgcg ctaattccgt
     1081 tgttgatatt caggccattc aagacgaagt tgatctaccg ctcattggtt taagcaaaat
     1141 cgactatccc gactcacctg tttacatcac gccaacaatc aaagagatgc gagccgttgc
     1201 tgctacgggc tgtgccgtag ttgcctgcga tgtcacgggt cagccgcgtc ctaacggtga
     1261 aaaattggcg gagattgtgg ccaccatgcg aacagaattc cctgataccc tcttgatggc
     1321 tgatactgat accatcgaga acgtcaaagt agcggataag ttagggtttg atattattgg
     1381 gaccacgatg cacggctaca caccagccac gactggtgcc aacattgctg ataatgactt
     1441 cgcctactta aaggaagtcc tccaagccac atcacgccct gttatcgctg aaggtaaggt
     1501 ggatacgccc gagaagatga aacgttgcct tgacttaggg tgccacgcgg tcgttgtcgg
     1561 gggcaccatt acccggccac tcgaaatcgc acaacgcttc attagcacct tataatttta
     1621 gacattaaaa ataaaagcca gtcgtaagca aaataactta cggctgactt ttcatttgtt
     1681 actgaaccat cgttaatgat ggtggatttg tcctgacgta cattcacaat agcgcaaatg
     1741 tctcatccaa atactatccc tcttgctctc gaatggaacc taccaaatca tccgtggctg
     1801 gagcgttcgc aagcaatgcg cgaacatcat caaggttcac cttaacattc caaactaaaa
     1861 caccaactaa cttaccggca tctatgaaat agacaagcga tccatgcgtt cgccgatcaa
     1921 aaatcaattg caatttagga tcaatattac cgattgcttg ccaggaaata tcaaaaatca
     1981 tggaatagaa gtatggggta tgttgatagc tcatgtgagc acctgccata ttacggccaa
     2041 ctaattcacc agaaagtcgg gcatggtcca cgtgctcaat ccgttgccga cccaagatgt
     2101 gatctggata agaggcaata tctccagcag accagatggc tgggtcacta gtattgagat
     2161 actcattaac tttcacacca ccatcagcta aatccaaact actatcttca gccaaactaa
     2221 tccgcggcgt gacacctaac ccaacaataa tcgtatcggc tgcgatcgcc gtactatcct
     2281 ttgtcaatag agtcaaatga tcaccttggc gttgatatga ttggacaaac tgaccactca
     2341 tcagtgtgac accattacgt ttgaacgttg cttcatactc agcccgaatg gactcaggaa
     2401 atttaccctc gcccagcgct ttttctggaa aaatcatcgt aactttagtc ccattttgag
     2461 tcagtgacga tgcgagctct gtaccaacat atccaccacc aatgatcaca actcgcttgt
     2521 tcggaccact aaatttacgt aacttgcgat aatctgacca ctgtctaaag actagcacat
     2581 gtggatcagc aggtccctgg atttgtcgag gttctccgcc agttgccagc aatagctgtt
     2641 catacttgat ttgctcacta tcagtcaatg taatgacctt atcttgccga ttaatagccg
     2701 taaccgttgt cttgaactta aaagtcacat taggataatt ttcagcacca atccgaatgt
     2761 tctcttcagt aaactcatca tctagccata gctttttact cagtgccggc cgttcatacg
     2821 gaacatccgc ctcttgcgaa ataactaaga ttgcgccctc tggatcttcc tgtcgaattc
     2881 ccttgatggc atagccagca gccattccgc caccaacaat gacgtatcga tagttgtttg
     2941 tctgatccaa atcactcatt taatcgcctc cataacttta ctttttctag gaccattgta
     3001 atataaaaac gccatgattc gaaaaatgac gctcaagatt attaatcatt gattcctttt
     3061 atcagaacaa taattttatt tgcataccgt caaacatcta tcaaacaccg ctgtgatcaa
     3121 aattaagaac tgctgctaac acaacataaa ataatgttat ttttaattac tcaacccaac
     3181 tttcaaggta agcattctaa ggagtgtttg atcacatcag ttgttgctat ggccgttttt
     3241 tttgatcttg tactaaacta ttgatcaatt cgctatgcta taataattgc gaatattcac
     3301 tttaactatc cgtcgtttac aatcatcacc cgttcaaaag tatcagtata ttcggcatca
     3361 taatgatgag ttggtccttt taatattcac ctgttaattt taaaattcga taagggagtg
     3421 tggcctatgc gtctatggca tgaacaatta atccatcaat taccacgaca acaattacta
     3481 ggtcaacacc gtgagcttgc cgcattgaga ggcaatggtt ggggtaaaaa tcatgcaacc
     3541 gttaattatg ttttcaaata ttccccttac aagttgcatc aatttcatgt attagtgatg
     3601 gatgaaatgc aacttcgcgg ctatcatcct aataaaatat ggtatgatcc aaattatcgt
     3661 gggcagtttt gcccgcctta tgatcacctc actcctattg cattaacaac accaatctat
     3721 ccagaacaca acgctagcta cttagcagaa tgtgtccgca atttagctgc taagggaatt
     3781 atcatgccca ccacatagcc gctcttttat tttgctgggt accaactcaa ccatcgatac
     3841 ccaaattgtt tttccgcagt cataataagg ccagttaata ttaaaaaagg ttgaactaga
     3901 cttgaagtgc aatagaaaag ttagacttat ttgtttaacg attgtagcgc atttcatacc
     3961 atgttcaacc tctttttgta gcatccatcg atgttatcta agcctcattc tatcaaaaac
     4021 gtgtcgtttt tctaacgcct taatgaagta aaaaatagca atcacctgta atggtatctg
     4081 aatgatgacg cgtgccaatc ttcccaacaa taacacttta aaatgagtgc caaatagtac
     4141 tgaaattagc catgagtcca tcatcaaact aacaaaaatc attacaagta tttgcgtcat
     4201 cacaacggat aaccaattga ctgatttacg atataaaaac aaaccgtcaa taaatccccc
     4261 taaaaatgca gttaacaaaa aggcaatctg aaacgcgccg gaaccaaaaa tattaaagct
     4321 taatatatcg gagatcatct ccaagagacc accccaaatg ggaccatata gataaccaat
     4381 acaagccata gacaaaaagc caaaagataa ttgaaaatac gctggtccga tagcaatttt
     4441 gtataaaata acgtctaagg ccaataagaa agccgatgta gtcagcacta ataaattcat
     4501 ttttggcaac tgaaaaacat ttttcgcaat aagtttagac ataggccaat cctctttttt
     4561 tgattttaat cataccctca ttcttaataa aagtaaatat tacttttatt aagaatgagg
     4621 tagtttaaaa ttgtcgctct tgatttagtt ccttgaactc aatgatatta ctcatactaa
     4681 aagccactaa caggtcaact agtacaccca tcagtggctc attgtaaaat taatttttat
     4741 ccatgtaact tatcttgtaa tttatcaccc aagttatcaa ttccctgagc agtaagtacg
     4801 gtcccaccaa taagaacacc acttacgatt aagattgcag ctaaacaaaa ctttaaaatg
     4861 cttttaatca tcgcaatcat ctccttacta atccatccgt gtcagaacaa atgaggttat
     4921 cgcaacaaca atcacaccac caataattga aggaacaatt gccattccgg ctaattgtgg
     4981 tccccatgat cccaaaagag cttccccaat tgcagatcca accaatccgg caataatatt
     5041 actaatccac cccatcgatt tacctttatt agtaatagca cctgcaattg caccaataat
     5101 agcaccaatg atcaaaaccc ataaccaatg cataaaatcc ctcctagact tattaaaccg
     5161 cttaaataca ataatagaat tacacgaata tttaagccga ttcataaatg attacttctt
     5221 ataattatca ttatacaatt atcgataatg atagacaaat ataacacatt atttaataaa
     5281 tgggtcgcta ctatttctca tgtgacgatt ccgggtggcc tagaaaatat caaacagctt
     5341 gatagctgat taaaattaaa ctacgccaca tgaacgatta acttaactgt gcataatgat
     5401 tgaagtcact ctgttaaggt gttagcgttt aaattgtgca agagctttct tgtaatttac
     5461 gtgaaaaggg tgattaaaat gacggaaaaa ttaacgacgg aaaccggcca accatgggct
     5521 aacaatgaac attcccaaac ggcaggagct cgtggtcccg tattaatgca agactataat
     5581 cttttggaaa aactagccca ttttgatcgt gaacgaattc cagaacgggt cgttcatgct
     5641 aagggggccg gagcaaaagg tttttttgaa cttgaaaacg acatggggga atatactaag
     5701 gcagacttat ttaatggtgt cggtaagaaa actcccgtaa tcttaaggtt ctcacaagtt
     5761 gccggtgaaa aaggttatcc tgacaccgtt cgagacgtgc gcggttttgc cttaaaattt
     5821 tatactcagc aaggcaatta tgatctcgtt ggaaacaaca caccggtctt ttttgtaaac
     5881 gaccctttaa aatttcctga cttcatccat tcacaaaaac gggatcctaa aacgaaccgt
     5941 cgtacgcaaa atatgcaatg ggatttttgg gctcattctc cagaatcatt gcaccaggtc
     6001 acttatttaa tgggcgaccg aggacttcct gcgtcctatc gaaccatgaa tggttacggt
     6061 tcccatactt ttaaatgggt taatcagaat ggcgaacagt tttgggttaa gtatcacttc
     6121 atctcagacc aaggcattaa aaatatgact gctcaagcag ctgaaaaagc aatgagccaa
     6181 gatttagatt atttacaaga tgacttatat gatgcaattc aagaaaaaaa ttacccatca
     6241 tggacgatgt atgtccaaat cttgtcatat aaggaaggtc taaactataa atgggacatt
     6301 tttgatgtca ctaaagtcat ctcccacaaa gactatccac taattaaagt cggcaaacta
     6361 actttaaatg agaatcccac taataacttt accgatattg aagaggcggc catgtcgcca
     6421 gcaaattttg ttcctggtat cgaaccatct cccgacaaat tactacaagg tcgcctattc
     6481 tcctataaag atgcacagcg atatcggtta ggtgccaact ttgaagattt actcgtgaac
     6541 aagccggttg ttccagttca taattatgaa cgtgatggtt acatgaaaat taataatcaa
     6601 ggtgctgagg tcaactacga gcctaatgca ctgcatgggc cagaagaggt gccggatgcc
     6661 gcgctttcac ctgattctgt tcgtggtgaa acacgcgcac agccttatcg ctatcaagtt
     6721 gattacataa ctcaagcagg cgacctatat cgcttaatgt cagaacccga gcaagaacgc
     6781 ttaattaata ctatcaaaga tgcgttaggc caagttactt tgcctgatgt caaagaactc
     6841 gaaatcaagc aattttatga ggccgacaaa aactacggta cacgcgtggc taatgctctg
     6901 ggaatgaata ttgctgatat tatcagtgat taatattttg accggatgtt atccatcgcg
     6961 atattatttt tgttataaag aatgatgatg ccgtctcatg gttattaact aaagagcgac
     7021 aggttagact catatcgtgt aagtctagcc tgtcgctcct taattaacaa aaaatcttag
     7081 atatagctta ctactcgacc atccttttat taataatggg atcccctgta ttaccatcta
     7141 gacgactcaa caatgcattg aactttagtc gccgaactgg tcgtggaata aattggcgaa
     7201 tatcatcttc attaaagcca acttgaattt tactatcact aatgatgata ggccgacgta
     7261 acaacttcgg atgatcacac aacaatttaa gtgcctcatt caatggcatt tcgggtaact
     7321 taggcgcaat ttcaggatag tctttagatc gagctgagat aatatcgtct acaccatgtt
     7381 cggttaaact caaaatacgt tttagatctt gcaccgtggg cgaatcaaca ctaaaatttt
     7441 tctccttgaa ctcaatccca tgtgcttcca accattgccg tgcaactcta gaagaatgac
     7501 agcttgattg tgtatataac ctaatcattc ctaatctgcc cctctctcgt taaaattcat
     7561 cacagcgtat tgatcgacat taacttctgc ctgtcacaac atcctttaaa ctaaacgcat
     7621 tcgttactgc catgaccaat ccaatacccc gtgaacacat ctttattata ggctctgtac
     7681 aagggacata ccgaccgttt taagacgaat aatctgagga taatcgtttt aagtacactt
     7741 ttaaacggtt taggaaagaa cgaacccagt acacgtaatg ctgacaaata ccactgcaat
     7801 ttctaatcga ataacgctga attttcatca cgtagcacat aaaaagtcgc ctactaattt
     7861 ggcaggcgac ttccttggaa ctattatgac tttttagcaa gccatttagc tagataacga
     7921 ttagcttgtg cagaacaaag cactttttca ccatttgtca tggttaatcg tcgcaagtgc
     7981 ttgtccaatg acttaatgcg tttcaagtta acaacatatg acttatgaca tctatagaaa
     8041 ttaggactca aatcaggaac atcctttaac agtccatagt attctaattc accatcatcc
     8101 aaatggacta cgattttatg gggactggtt gaactttcaa aaaatataat gcttttaaca
     8161 ttaattgatc tgaccgtctc accaattttt atttgaacat agtcgtcttg gtcattttca
     8221 tcggtttgaa aacgatcttg cgccacgtgt aaaaccttgc taaatcgctc atacaaggaa
     8281 tctggaaaat ccttaagaat aaaatctaat gcctcaactt gatattgaaa caccatcaaa
     8341 gataactccg tgtgtgtcgt gataaaaata atcttgctgc gccggcccat gtcacgaatc
     8401 tggctagcta gttgaatacc attaacatct gaattaaggg caatatctaa cacatagatt
     8461 gccttttgag gctgctgtgc attaaccttg tctaacaatt cgtggggatc ttggcatgct
     8521 aaacagatac tcatgtctag ctgttgatcg acgattacct tagtaatgat ttgacgtatt
     8581 tgttgtaatt gtttcggatc atcttcgcaa atatagacac taatcattct gagatactcg
     8641 cttcaccgtc aagcgttgta agaataccgc tcctaagact ctggtttcga gtatcatgtt
     8701 ctcattgcga ttaacaatct tacttaaact attcaatcca atcccccgat tcttgccctt
     8761 agtggaataa cctgcctctt tcagcttcca taagggtggt aactgttcaa aaacattgtt
     8821 ttgaatcaag aacaccgtac tatttttttc gataaaaatg gcactcataa tctctccatc
     8881 agcatgtcct accgatgctt cgattgcatt atccaacata atccctaatg caatgtctaa
     8941 atccaattca ttaacagtaa tgtcaattaa tggttccttt aaatcaaaat gaacttcaat
     9001 ctcttgcgat tgtgcatagc tcaacttact aaataggata ctcttaatcg acttcacttt
     9061 gacccgactc aaatcttcaa gattatattt ttcttttaac acccgatttg aaaccggtgc
     9121 aagattcttt tgataatatt cttgtaaacc ttctaaatca tcagttttca aatattcatc
     9181 tatcgaaatc aacatattct gatagtcatg tctgaaacgt cgcaactcat tatagtgagc
     9241 ttcgatttca ttcatataac gagtatcatt ttgtatttgt attctttgct tttggacttc
     9301 atatttggct cttacatttt ttaaatattc gttataaatc accaatacta accccattac
     9361 aactgacaat ataattaaat tacttaatat aacctggaac ttattttcca gaccttcact
     9421 caacataata tacaagtata ttatcattaa taatagtgcg gttatgcgat ttaagctctg
     9481 attactaaac gtgggactga aattcgtgcg atccattaca atattaagaa aaattaagct
     9541 tacgacactc aatatgacaa acactaccac atacccatta ggaactttca ttaaacgagt
     9601 taatatatca caaatatggt caaccataat cgaccatatg aacacttgaa atgttataca
     9661 tagtgcaccg cttagaactc gtacatacca ccaagtgaaa aatataaaca tcattaacat
     9721 taaaaaagaa aaactaattc ctaactttgc taaaaaaata taactcatca gcatacagac
     9781 ggataagaat ataacatcaa aaagtctcac aaaaaatata tttctcaaca aagatttaat
     9841 tatcaaatag atagataatt cttggaagac aatcattaac atatatctac actaatcctt
     9901 gctttttaat tcatcaggaa ttttagtttc gaataatatc ccatggcagc acataaccaa
     9961 ctgtttagta cctacgtatt gaaaaagatg gctaagtact ttatacattt tttctttcat
    10021 aattttccct cctttcatag ggcattagca ataaagcggc taatgccatc gcaattaaaa
    10081 tgattgtgcc aaaataatta ttactaacta tttgtaacaa actcaaaatt aatgacaatc
    10141 caattgcccg tcgctttaat ttttttctca atgacttcga tgtaatagga ttctttaccg
    10201 tatcagctgg agcaaaaata cttatgatta ttacaaatat taaacttaat aacaatctgt
    10261 atacttcaga aataccagtt ccaatcacat acggcacacc cacaaacaca aagatagtta
    10321 atatcgtaca taacaaatcc gatttcaagt gacgtccata ggcaaagcca cgcaaaacta
    10381 aaaaactacc cataaaaact aacactggga ccaactcgtg tagcagcaac gctaagataa
    10441 tagtaattat cagcttagga ataacattta atacagtatc aatgcctagt ttaactagta
    10501 atgcctgccg tctttctagt tgaagattct tttgaatcgc agcgaataac cgatcgctta
    10561 atttataaag caatagtttt tgttctggct tttccatatc ccactcctat aatgctcaaa
    10621 tacatacctg tatcaacagt ttaaaacagt attaattaat tgaaaagaat acataaatag
    10681 attaattatt caatattgtt ttaagactag aaataaacat ttaaagatac atcagtttaa
    10741 ttattcatac gaaactaaag tttcatataa aaagatcgtt aatataaatc agtttcatcg
    10801 atactccccc ttaatttttc cttagattac aagtcaaact agacttaatt tcactaattc
    10861 acattactca atagattaat atcaaatggt gaaaatcaac gaaaaaagga gatctatcaa
    10921 gcaatctcct cttacataaa gttatttatg aacactgatt taagctaagc tgccgatatc
    10981 acaatctcag catccactaa atcagccttc aagtttttga catctaagtg gtcaaggtag
    11041 aaatccgtta ccttatcacg aatttgttgt tcaattactc gccgtaatgg ccgcgcaccc
    11101 attgcttcat catagccttg ttccatcagc caatctttgg ccgctttagt tacctcaagt
    11161 ttaatggatt ttttggctaa cgttttttgt acatccgcca acattaaatc gacaatttga
    11221 cttaagtctt gcttagtcag atgtgaaaac tccacgattc cattaaaacg gttcagaaat
    11281 tctgggcgga aaaatggtgc taacttatcc attaatgact gatctcgttg cttgtcacca
    11341 cttaatgctt cattaccaaa gccagcatta gaagtagcga taataatcgt atttttgaaa
    11401 ttaatgacat tgccttgtcc atccgttaag cgcccatcat ccatcacttg taacagtaac
    11461 gttaatactt gtggatcagc cttttcaatt tcatctaata atacaatgga atatggatta
    11521 cgccgaaccc gttcagttag agtattagca ttatcttcat agcctacgta tccagccgag
    11581 gtaccaatta atttcgacac agctgtacga tcagcatatt cactcatatc tagccgaata
    11641 atcgcatttt tatttccaaa catatctaag gctaattgct tagctaattc agtctttcct
    11701 acgccagttg ggcccacaaa cagaaaactt ccaattggct gatcaccctc tgaaaagccc
    11761 gcacggttac gccgaattgc cttcgctacc atttcaaccg cttcatcttg accgattacc
    11821 ttacttttca gacgcttatc aagatttttc aagtgctcaa tatcattagc gcccatatca
    11881 gcaactggta taccagttaa acgttcaacc gattgtgcca catcatcaat cgtggcagtg
    11941 attttttctt tttgatccgt ttttttaatt ttttgcttgg tttcctcgat cgacttcttg
    12001 atatcagcgg cttttgtaaa gtcctccgat ttaacggcgg cctccttagc tgcctctaat
    12061 tttttaacgc gttgatccaa tgtctcaaca tcagtttgcg aatttttagc cgctaaatga
    12121 gccgcagtca tgtcgatcaa atcgatagct ttatctggca aagtgcgttg tggtatatat
    12181 tggattgaat aatccacagc cgccttcaaa acatcatctg ttaatacaac atgatgatgc
    12241 ttttcgtaca gctttttaac accttgtaat atacgtaaag tgtcagcggc cgtcggttca
    12301 ttaatcacaa catcattgaa tcgccgtgcc aaagccgcat ttttcaaaat agtattgcga
    12361 tattcatctt gagtcgtagc cccgattaca gtcagctcgc cacgtgacaa agcaggttta
    12421 atgatatcag ccaatccctt gccaccgtct tcaccaccag tggcacccgt gccgataatc
    12481 tgatgaattt catcgaagaa tagaataata ttaccagctg ctttaacttc ctttaccaac
    12541 tgtttaatat tctcttcaaa agaaccgcga tattgagttc ctgcttccaa agacgataaa
    12601 tcaatcgaat agatttcttt atcttgaatc gtttctggaa ctttaccagc cacaattgct
    12661 tgtgccagac cttcgacgac tgcagtttta cctacaccgg catcaccaac taagattgga
    12721 ttatttttcg ttctacgact caaaatttct gcagtttctt gaatctcatt ctcacgtcca
    12781 atcactggat ctagtaatcc atcacgagcc tgttccgtca aattagtccc taacttttct
    12841 aaaatccctc cttttttaaa agcctgttta ccatctttag atacttctat tgttttatta
    12901 ttttggggta gcttaccagt tgctcggtat tgagcaaact catctggtgt caacgatttt
    12961 ccattaacta agtaccgtgc acgctccgaa ttttgattat ccatgcgccg aaataattga
    13021 ttgaaaacat catccatatc attgttgaaa aaaggatcat tttcgtagaa attcgccata
    13081 gtacaacacc tccataaaaa tttacacgtg taacttagtg accataatat cctttaaaac
    13141 ttcagctaat tgtatcacga ttttttatgt atcgttaagt aaagtgctta tagaatcaat
    13201 tagaaataat tagaataatt ttgtttaaac aaaagagaaa tcaatttcat aaaatgaatt
    13261 gatttcccta caaggttccc tatttaatag cccttgataa agaacttgaa ttaacaagtt
    13321 actttccaga ccaattttaa tttaagagac tacgactcaa caagcacacc cagtatcaag
    13381 ttaaggccaa ctagttatcg ttaatattgc cacttaaata tcaatactag caatcatgac
    13441 acacgtgtaa aatcataagc caaaacatat tacatgacgt aacggcagtc ttgggactgt
    13501 aaactcacag taatgattct attgagttgg ataaggtgcc gatgaccagt aattgccata
    13561 aatgcaattg ctttcggtac aatcgtagtg acatagccaa ctgtctcggc catctgccca
    13621 tttgttttat aaaaccgtaa tgagactcga catttttgat catgcgcttg ttgtaattta
    13681 caataattat tttcaacact caaattaaag tctcccgttc aaagaattca ggtttattta
    13741 ttcgtcagtg aatctatgtg tttgtttttc tcattgttga cggcgtaagt ccacattaag
    13801 gagtcagcta ttcagtaaaa actaaataac tagtattcat gttcagctca gtataatatg
    13861 cattgatggt tactaatcaa aaatcgatct ctaaatatcc taattactat gaaactttga
    13921 agttaattta tgagaaaaat aactcacaac aaaactcatg attacaacct tgtcatcata
    13981 actagattat gaaacattca gcctcctaaa taaaactggt atgtgcgcat gtgtacagta
    14041 tactattgcc aagtatgtct gaataaccgt tttaagactt gaaaaactca gctgggtgct
    14101 ttaggacgct ttttgtgcat tttaagacaa tatcctaact tcaacgccgg catagcttca
    14161 attcgtcaat cagtgtctta gtttctcagc tatttctgtt cagaacatct tcctattaca
    14221 ataaaaagcg ttgatctcag cagaatttac ttccaccaaa accaacgcta aagtgttatt
    14281 atatcaggta ttttaaattc atttcagaca ttatattcag cattacttct actacctaag
    14341 taatttagca cgtttaacat cttcaatcgt cttagttccc gctagttgca tatcgatcaa
    14401 cagctcatca ttaaggtgac tcactacgga agcgacaccc tgcgcaccac ccaatgctaa
    14461 tccatagata atcggccgag caagtgccac cagatctgca ccattggcta acgccttaaa
    14521 gacatgggag ccacgccgaa caccgctatc aaaaattatt gggacgcgcc cattaacggc
    14581 ttgcgcaatc tcgtgtaaaa catcaaagga agctggacca ccatttaatt gccgaccgcc
    14641 atggtttgaa acatagatac cttgagcacc agccccgatt gctaacaagg catcttctgg
    14701 tgactgaatc cccttcacaa taactggtaa attcgtatgg cagattgtaa aattaatccg
    14761 aataagtccg atagttttca atggccgttg attaataggt tcaagtgctg ctatgatctc
    14821 attaattgtt acatggttaa agttggactg tttgagaaaa accaacataa ccatcgatta
    14881 aaagattcat tagcaaccta catctataaa tagtatgata ccatgtcatt tatagatgta
    14941 gtcggctatt gtggcccaaa ttaataaata ccacgttggc gccaactgaa ttaactatta
    15001 aaatttcggt ggttaaaatc agcaatagta taactctaac attcacgata agtaactacc
    15061 agcgactgga taagtgtacc tttttaagga ggcccaaaat tgatgttacc attattgatc
    15121 ttattagttg agtttgtttt actcatattt cttggtaaga ttcgaaaaaa aattatggac
    15181 tatacaagat cagacgagtt atatttttgg ggcctctttc taaaaaaaag cgattcccgt
    15241 caaaagatga aacagatcaa gaaaaaagtc cttcaaacgt atcgtagaag ctccctaaaa
    15301 aacgaactac tcttctggct agagtttaca gttgctagag gttgctttta tggttcgctc
    15361 atgtggctct ggtacatagt tgctttcgga aatagtatca tccaaatccg accagcaatc
    15421 attggcttta tgattgctat tccacccacg atagcacttc cccaacagct atatcatttt
    15481 tggaaacaac aacctatttg gcatgagcag cctattgaaa aacaagcttt cctactacca
    15541 aacgaacaag atcacaaagc cttatttaag taccatttac aatcttactc tttattgtta
    15601 ctatcgttgg ttataggatg gtttggtaca ggaatctgag tgctcaaaga acaaggtgag
    15661 aaactaattt tggtttctca ccttgttctt ttttatctaa attttttatc ttatccttta
    15721 ttattcgtta aaaattttgt ggcaagtgct acaaatgctg cgacaacacc cgcagcagac
    15781 gctgaaccag caattgcagg cgccattgaa ataattacag ctactgaaag ggtagcggct
    15841 aatgttatcc caaatgattc agcagggtcg taggtaggcc agttatcgaa gtcgctcttg
    15901 ttgaaagtaa catcaatttc aattgttaag gtctcgctta atgagccttt ttcaacttga
    15961 tagacataat atttcaactt aaaactaaac tcaccgtcct tactatcacc aatttctaac
    16021 tcaaaatttc ctttctttat tttctctgaa atcccccatt ttccaatacc atcaacagtt
    16081 aaatacccaa tccaatctgg aagtttatac tttgtttcta gaatagctgt tagatcagct
    16141 tccggtaatt cgttatttga aatagtcaca atgtttgaac ttgatttatc agctacttca
    16201 ttagtagcaa gccaggtaac cttaaacggc ccaatagttt gaacgtattt cccaccaatt
    16261 tgcaggttcg tattccctaa aatctattta agcgcttcat cagcggtgac accacctgta
    16321 cttttaaatt ttttagtccc actatcacga ccagatgatg catcttggtc aatgtcaaca
    16381 ccagaaccag tagtatactc tacaaattga tcgaagcacc aattcttggg cattggaaac
    16441 ccgaggttac cgctccatcc ataagacata ttagccacaa agaaattcga aattcccata
    16501 ctttctgccg catgtaggca aacattccgt gtcccatata acccagtttt atagcctaag
    16561 tcagttagtg atgctcgtac ggcttgcaag tacgcaataa ccgtaccctc gatgtctcca
    16621 tcctgtaaat ctaagtccgc tgcaaagtag atcacggtac cgtctggaaa gccgagcgca
    16681 cgagccgcat atgctgctag gtatgcgtct ttagttcctt gtgattcagt gaaataacta
    16741 acttcatacc caccgtcctc atagatagga aaaatcgaaa aacccgcagc agttaattta
    16801 ctaatttcat cagatgtcaa gttcttggct tttttcggca ctacccgttc cgacagatcc
    16861 cgttaagtaa cggccaacga ttgaaaaacc agcttggtac agccgttgaa tcatactagt
    16921 atctgtcagt tgggttgcgc aatcaaaggt attagaatct cgaccggtat caccattact
    16981 agttagaagt cctttaatca ctcgcaaatc agctacgcct gaataagtcg aggcactact
    17041 taatgagcca tcgggtaaaa tcataaactt cctaaaagcc acaatctcat ttgcaacagt
    17101 agtgctgaaa tacccatcaa aggctccaga ctgatagtag ttattcacat aaagcccata
    17161 ctgaattagt ttaacgatat taccatgctc gccgaccttg acagtgggcg tcaaagcaat
    17221 agtttgatta ccgtaataac cattggcctc actgggtgac ataccttcga tagcctggag
    17281 agcatagatt agtgcctcat ttgtgtcgcg ctgatagatt ccatcacaag gtctaatacc
    17341 aatataactc tcataattgg catttaacca ttgctgcatt gcccgaattt tagcatctcc
    17401 attttggact aatacaaaag cactcatatc aaataatgca gccatcaagt tagttgtcat
    17461 tgtaccattg gcagtaatac cagcatcact ttgtaatttc ttaactgctg ctatcgtatc
    17521 agccgaataa acagttgaaa aatcatttgg tgaaattcct ttgcaccaaa aggctccttg
    17581 aattagcttg gcaacattac ctttataatt aagcttcaaa tttgcaacga agccatctac
    17641 cgccttccgg gtggcattac caaacccctc accaagtggc gaaactttta attcgtattg
    17701 caatccttca cgcaaactat aaatagttgc ccagccagtc tgtccatttt ctggtgcctt
    17761 tttaaaccct tcgacattac catatgttga atttaaccgg tagcgtcaag aatcttgtgt
    17821 aaatgaaatg ccttcgtaca tataatatgt atctaactta aataaatgat gcttccaagg
    17881 tgtcctggag tcc
//
