LOCUS       gnlProkkaGPMBJKHM_47   17035 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPMBJKHM_47.
ACCESSION   gnlProkkaGPMBJKHM_47
VERSION     gnlProkkaGPMBJKHM_47
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 13:55:47
            Original ID  :: gnl|Prokka|GPMBJKHM_47
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17035
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17035
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4610:7035]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4611..7035
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17035
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17035
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             159..272
                     /locus_tag="ctg28_1"
                     /transl_table=11
                     /translation="MPTKIWLKPEQLDLYIKHLERFRDLYSKLDCSGIVNL"
     CDS             501..602
                     /locus_tag="ctg28_2"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             772..1041
                     /locus_tag="ctg28_3"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1201..1500
                     /locus_tag="ctg28_4"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1600..2511)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg28_5"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2741..2830)
                     /locus_tag="ctg28_6"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2827..3429)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_7"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.2e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3523..4614)
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4611..5930)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_9"
                     /sec_met_domain="Streptide_RRE (E-value: 9.3e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.6e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.4e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.6e-07, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNVFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6000..6092)
                     /locus_tag="ctg28_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6175..7035)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.7e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7275..8111)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg28_12"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8105..8671)
                     /locus_tag="ctg28_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8850..9008)
                     /locus_tag="ctg28_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9020..9151)
                     /locus_tag="ctg28_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9161..9673)
                     /locus_tag="ctg28_16"
                     /transl_table=11
                     /translation="MAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             complement(10073..13252)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 497.2; E-value: 1.7e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg28_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13249..14457)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_18"
                     /sec_met_domain="Metallophos_2 (E-value: 4.1e-10, bitscore:
                     31.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 acggtaaaat gacaatcctg gagaagtaat ttaatttatg actaaaaatc agcaaaaata
       61 taattatgac taaggaatat tttattaact aaatgttgag atagcacaag gaaatatttg
      121 tgctatcttt tttatttatt aggaaaagag aaaaaattat gccaacgaaa atatggttaa
      181 aaccagaaca attagatttg tatattaaac atttagaacg atttagagac ttatatagta
      241 aactagactg ttctggtata gtaaatttgt aacactccta cctaataagt taaactattc
      301 attagaatag gagacataac atgaaacact atccagacga aacacgataa aaaattgttc
      361 gactgcacat tcaagacgga tgaacattaa aaagcttagc tgctgaatat ggcgtatccc
      421 aagcctcaat ctctaattgg gtaagacatt atcgcaaaga atgccaaact aataataaag
      481 aaaaatcaca gcttgaactc atggaggagg ttcgtaaatt acgtcaagaa aaggcagagc
      541 ttgaaaagga aaatgatttc ttaaaaaaag cagcggcatt ctttgcaaag gaaatcgatt
      601 agaggcatat cgttttattg ataactataa agaagatttt ggtttgcgtt ggttgttctt
      661 gcatatgaat attcatccca atgcttatta taattatctt aaaaagacaa ggactaacta
      721 tcatcgtcaa aagaaagcta ttcttaatac tattcgagat atctaccatg agtgcaatgg
      781 aaagaagtaa atcaattctt cgaaacagaa agcatcaaac tttctgatat agagccttcg
      841 aaagttagtt atagggaggt acaaaggaat caaatcaata ccactattta taatgaaaaa
      901 ggtaatataa aggatattga tactagcatt ataagagata tgtacgataa aagcaaacct
      961 actttaaaac agggagccta tatatccgct atagcagctt ctctagaagg ggggtactgc
     1021 atttataaca gcaataatta aaaaaagcgc ttagggaaaa ctattagtga gtttacaaaa
     1081 gacgattgtc ttgaaatttc taaagatagt ggaattggag ctataaaagg aagtactcga
     1141 ggcattacga tatacgccct aacgaattac acagctactc ctgcagcagt agcaagttca
     1201 ttgtgcactg cttcatttgg tatcgctaaa gaagcataca aattccgtaa aaacttaatc
     1261 acaaaagaag aatttttact aaattcgcaa atattatgtg ttgaagtatc agttagtgca
     1321 ttatcctcaa tattaggaca tgctgtaatt ccaataccta ttttaggatc cgttattgga
     1381 aataatatag gaactttcct atatgaaatc gctaaagata atctcacaat gaaagagaaa
     1441 ttactgatag cagattattt caaagagata caagaatata actatttttt agataattaa
     1501 tttgaattat ataatcatca acttcagaga gattaagaat tactataaac ttttagggaa
     1561 ggcattttct cctgactata atatcgcttt tcagggatct tatgaatttt taaatatgtt
     1621 ttttaaaaat acgttaacct ctcctatttt ctctgcttca ggtaaataga tagaaacggt
     1681 tgtcgaataa acaaaagaag gtacactcac aattgaaagc aattgactaa taactgcata
     1741 aatagccaac aattctactc ctaatctcga catcaaggca tcaaacacca taataaacaa
     1801 aacactctcc agaatttctt gaccaaccaa aggaatacca aatgttatta attcaaattt
     1861 agttgtagat gtaatggata aagccttcaa aatcattgga taaaccataa acaagtaact
     1921 aagcgatatg aaagctaagg atacaatcgt tgatatggct gctcccttaa ttccgatttg
     1981 tggtaccagt acataattta acacaacatc tattaatgaa ctgataagtc caacccacat
     2041 aattggtttt gttttctttt gaactcttaa taaatttgtc agcgaaaagt ttaataatgt
     2101 caatccgata tatggagaca tgaagactaa ataaatggtg gataaggaca atagttgccc
     2161 tttaaatcca tagagctgct tcaagattac atttccaaaa ataatgacaa aaaccgcaaa
     2221 ggcaactccg ataattaaat ctaaggttag atttgatttc aataaatcat caaacctgtt
     2281 agtttgccga ttagagtacg ccttagagct tttaatatta aatgacaaac tgaatgctcc
     2341 taaaagtcca ccaaaagcaa ataagagatt ctgaataatg gaaattcctg acagagcaat
     2401 tgaggaattg ttcacagcaa aatgcaatgc tatctgccca ataattactt gaccaatatt
     2461 tgttaaaact aagggaaagg caaatttgtt aatttctttt gaatctatca tttttcctct
     2521 ctaaaaggct tcaaatgtaa gtaaagatca gatttaacta aatttgcata aataatatgc
     2581 aaaataggag tttcttctaa aaatgaaata attgcctgct tacaatcatt agcagatacc
     2641 tcataatctt gctgtaatag ttctacaatc ttgtctaaag aaaaattttt agaaatgcaa
     2701 taaagtattt ctgctcctat ttcatcaaat gaatagtact ctaatcaagt agatcgtatc
     2761 ctatgtattc atctgctact ttatttacaa tgaaatctct cttacctctt atcacaaaat
     2821 gttctttcat acgactactc cacctccttt ttgttcataa aagcaggcta aatcagagcc
     2881 cagtaacgtt ccatctaatt ccaaggcact gcatcgacat cccccaccac accatggtag
     2941 gggacattct gaacatttcc cagaaatatc atcaaatgta attgatctta gtttattaaa
     3001 tacagcagaa tggtgccaaa tttcgctaaa cttttgttct ttaacatttc cagcaactaa
     3061 ttcatctata ccattcatca agtcacaccc gtatacatct cctttatgat taattgaaca
     3121 tgctctaact ccagcttgac aagatatttc ccttggctta tcaaaattta tatctacttt
     3181 ttgatgccaa acattttcta ataaatctga tctattataa aatgcaagcg gaaaataatg
     3241 tgtcaaaaaa acatcacttt cattaggagg aacaatttta aatttaactt tgaactctcc
     3301 tttagaaatc cgctctgtta aatcaagaaa aacaggatac cattgttttt tatctgctaa
     3361 aatactaccg tcattagccc taccagtagg acaaataacc ataactgaca tatactcaat
     3421 accaagcata tcattcaatc ttatactcta aagaaaatat ctgctaaatt tgcaaacaat
     3481 tgtgctatca ataatttggc aaatgaatta gaaatacaac ttttaagttc ttttctctct
     3541 gttagaaaat gaataagata ctaagcaaca aagagctact ataccaaata ttaaataatt
     3601 gctcctaata ctaaagttat cagcaaaaat accagctagg aaatcagcta acataaaact
     3661 aatcgaaata aacaaattat atactgacca tgatactgct ctattttttt ctattgacat
     3721 attaaattta taataaaaat gattattgta gttggaatta agaacacgca ttaataaaag
     3781 gattataatt tggatgatta gattagtttg aaaaaacatg agtatagcta atactggtaa
     3841 catcaagctt acttcaaact taatttttag ataactcccc aaagccatag atatattaaa
     3901 cataaatagt ataattccca gcatatctag tgaaagtccc tgttcattta agaatatccc
     3961 tgcataagaa ttgctaatca taattagagt tgagaatgct actcctaata ttattaataa
     4021 ccatggaata ttttgaatat tatcgaggct aaaaaatttt tgtttattat tttgttcctt
     4081 tttaatctcg ggtaatccta ttaaatataa taaactgaaa attacaaata caatggatat
     4141 aataatagga taaatataat tcctatgcaa taaaggtgga gatataatcg taataatagc
     4201 aataaaaata tattttaatg tgttgagatt tttcaaaaat gatttatata caacttcgtc
     4261 atcaattatt tcaaaattat aagaaataag aactcctgaa gataatgatt ctgacaatcc
     4321 aaaaaatatc gctgaaatat atattatatt tgattttcca aacaataggc cccataatgc
     4381 taaaattaat aataaatttg aaatagccaa aattttcttg taaccaatct tacttgaaat
     4441 ataacttaaa ggaatatcaa aaactgagcc acatagctca gtaataactg ataaagtagc
     4501 tatttctgtg aacgaaaaac ctaagtgctt taatagtaaa attcctacaa agtagtacgg
     4561 taatccagat agaaacatat tcattccgta taaattaaaa atcttcttac tcataagtta
     4621 caaactgggt ctctaaaata ttttggactc ttctccttaa tcaagttaac atagcagcca
     4681 ccctcgcaaa tttttaacaa tccacaagat aaacacttag aattcttcgt tctaaaagaa
     4741 cgaatccctc catacaacgg atcatcatac caaacatcta acaaatcttt ttcaaagaca
     4801 ttctgcttag tttgattaac tcctaaaaaa gcaatgcaag gcaagatatc cccattagac
     4861 attatttcca tcttagtata ttttgcacga catccataat acatttcgcc aaactctgaa
     4921 aattcaattg aattatttat caactccgga taagcggtga aaagatgaca tccctcagta
     4981 gcaaaattta aattagcttc ccgttgagtt atataatctg taacatactc attcaacctt
     5041 ctcaaatcag ctaaatcgta ttttttcttt attttcgtat atcctgttac ctcagaataa
     5101 ttagctactg aaaatctatc tattttattc tctatacaaa aatcaaccaa ttctataatc
     5161 tgctcatagc tttgctttgt atacactgca ttaattctac atttttttcc aacctcttta
     5221 aagtacttcg ctaatttaat ttgtctatca ggtctcaccc ccattaattc aaaatttaat
     5281 ttaggatcta aagtctgcaa agataaaacc ggtgtaatat atttagattt agctagaatt
     5341 tccactgtac ttttctttat taattgggca ttagttgtta tagtagtctt tatcttcagt
     5401 tcttcacaag ctatcaacaa attatcaata tcaaaatatc tagtcggttc ccctcctaaa
     5461 attgaaacac ttaacactcc attatctttt gcttggcgca aaattctttc ccaatcttta
     5521 gcaggtttgg catttctatc ttcacgattt gctaaaaaac aaaaaccaca ttttaaatca
     5581 cagtacatac tggggtatat tactagttca agcggaaaac tcaatatgtt atgttttttt
     5641 aattttgcta catgctttct cgcattttga agagtctcgt caggattttt cgatgatccc
     5701 tcaatattat tatcagaata gatatttaat aagagtactc gctctagttt ccctgctttt
     5761 atttctttct taaaaaagga cgtagcaatt tcaaaaccat gattttgaac caaataaaga
     5821 aaataagctt cactctcatc taactcaatt cggtcaaaag ttactttatt tatcaaaatt
     5881 ccaccaaact tttctagtct aaataaaaaa tcttctgaaa ttgtcatcat attgaatacc
     5941 tttctaaaaa agcagaggaa aatatagcct ctgcttaact tatgggataa attactttat
     6001 cactcccagc cgtcaccttt tgccatcacc ttccagccgt caccttttgc cattgaacta
     6061 gactcaagga ctttttcaag ctctttagac atatttggta ctcctttcga atatgatact
     6121 gtgattatat ttcttttcaa cacttacaat aaaatattcc catatttgca ttttctaact
     6181 actagctaaa attttttcta aatgtccttc ataagtcttt gctaagtgat gacttcctgc
     6241 taatttcatc gctccaacac acttcttcat ttcaataatt gctttcacat ttccatcctc
     6301 tttatattga taaagatttt gtgcatactt aaagactaaa cgttcatata cttctgtctc
     6361 aataaaaaag cattgattta gctgcttttc aaaatataaa gcatccataa atttttctct
     6421 ttcaacacat gtaatatatc catttaaaag catcgttgaa attaatcgtc tgttatttgg
     6481 aatttctttg taaaaatcag aacgcctaaa catttctctt gctaagacca tgaaaacatc
     6541 atgatttaat acatctaaag tattcgagaa aatcaataac tcatagtacc cccagtattc
     6601 tacactaaag agataatctg ttaaatatgt caaatcatcc tttgtatagt aagtttctcc
     6661 tgataaatcc tgtagacgaa ttttcaataa aataatattg atttgatgaa atttttctcg
     6721 cctatcttcc agttccatct gagaataaag taattttttc ataccttcta cgtcacgtgt
     6781 tgacacaaaa tgacgtactt tcgataacag ttcgtttaac tcatctctat gaaaatcatg
     6841 gaccgcatac ataaattcat ctattggcat attgatttca tctaaaataa acatgaactt
     6901 tgaaatcgtt aaatctgttt ctcctttctc aaatcgagag agctgagacg ttgatatacc
     6961 agcctttgcg acgtctttta atcgtaatcc tctcgattct cgaaactttt taaaaatttc
     7021 tccaaatttt ttcatactac acctccatca cgcatatatg ggaataattt tcatttgctt
     7081 tcatcatatc atacaataaa gaaaaacaaa agtgaggatt atcacatgaa aaagcaaatt
     7141 ttactaacac ttcttcttgt cgtatttgaa ggcattatcg ttatcgtcgt gggataaaga
     7201 gtctgggaca aaagtccttt agctccaaaa agcaacggca taatgtactg accccaaaaa
     7261 gttagacaaa taatttaagt aaaggattta gttctgtatt gtacaggact gagtcctttt
     7321 agttttacct taatgcgttt gttgttgtaa taattaatat agtctgcaat tgcttgttcc
     7381 aaatgctcaa ttgacttaaa cgtcttctca taaccataaa acatctcaga cttaagaatg
     7441 ccaaagaagg attccatcat gccgttgtct ggactattgc ctttacgtga catggatggt
     7501 tggattcctt tctcctctaa aaaatgatga tagaaatcat gttgatattg ccatccctgg
     7561 tcactatgga gaattgtatt tttgtaatgt ttctctgtaa aggcttgttc taacatagct
     7621 ttcacttgta tcaagttcgg tgacttagaa agattgtagg cgataatttc actattgaag
     7681 ccatctaaaa ttggcgacaa atagagtttt tggctgcttg ctggaatggc aaattctgtt
     7741 acatctgtgt agcatttttc caatggtttg gatgcttcga actggcgttg gatgagattc
     7801 tctgctttca taccaacctc tccttgatat gaagaatact tacgtttacg gcgaattcta
     7861 gcggttaaac caagtacttt cataagacgt tgaactctct tatgattaat cacaattcct
     7921 cgatttctca attcaagagt cattcgacga tagccgtaat ttcctttatg ctcagtaaaa
     7981 atggcttgaa tttcagcttt aatgtcataa tccttatcat tttgatccag ctgttttaag
     8041 tggtaataat aggttgaacg agcaagctta ataatcttta gaagcatatc taaagaaaac
     8101 tcagttacca atcctcggac aatttccgtt tttcttcttg ctctttttct tccctcaatc
     8161 ggagttctct caacttttta agaactgcat tctccgctct aaggtactca ttttctgctt
     8221 gaagacgttc catttcttcc agttttttct ttggcttacg tcccatttta gataaccttc
     8281 ctcttgtttt ctcaacaata gtatacccgt ttttcttata gtgtgcgagc cagttaggaa
     8341 gcgtcccacg atttgggaga gcatattcaa gagaaactct atcttgagaa tagcctttat
     8401 ataggacttt atcaatcatt tcttgtttta attcaggaga gtagtaacga ttctttcctt
     8461 ttttagcgat ttctattccg tatcgatcaa tcaatttaat catgtagcta agattagaaa
     8521 tgtttatccc aaatttattt gaaagctgat ctaagctata tccttggttt ctaagttcat
     8581 agatttgaac cttatcttca taagtcaatt tcataataaa aacaccccga aagttagatt
     8641 ttttctgtct aacttttggg gtgcagttca taaaaccgtt gctttttgca tgattgtgat
     8701 agacttggtg aaatagaatt gaccaaaaat cttctgaaat ataacaagag agtgactcga
     8761 atttaaaaag ctagagttcc acaattggaa atctctagct tttttgtgac tgagaacttt
     8821 ttgtcccagc ctctactttc tactgactac tatcctgcat gccctaagtc gagatagaga
     8881 atatctcgct tagtggcata ctctagcgca tgttcaacag cctcaaataa atctgaagct
     8941 agaaaccttt tcgtaaagac ggtttcgtct ttacgcttaa atttcgcaac ataactatgt
     9001 ttagtcattt tttctccttc taatattcat attgtccttt aacaccacta tagatccagt
     9061 aaactgcttt atcataaact tgtttaaagg agatacctaa tcgattggct acatcaagaa
     9121 ttgaaatttg cttacattcc tctatattca taaaatatca tcattttgtc gtagtattcg
     9181 gcaatgatgg aacagatgag gattcttcta aagttttagg agttgcctta tctagatcat
     9241 ctaacccaga tttccaaacc tgtacttggt tgaccaataa cttaccaggt agtttcgaat
     9301 agttcaaatt aaccgttctg gtttctgttt ggtttgtctt tgattggttg gcattcttta
     9361 aatcagatac ataagttaca ttataagaga ccatggcaat ggcttgattc gtagtctgat
     9421 tgacaaagat atctgctttt tcaaaatgat aatccaaaat atagtcctta tacacttggt
     9481 tcatggcatc attttgactt gtcaattctt gagaataggc cgattcagtc atataaggtt
     9541 gaatacgtgt attattttcc cctagttttt ctttcgtata gtactgtgtc aaaaattctt
     9601 ttacagtatc tgatgataaa atacttgctt tatcttctgc ttgtttgtcc tctacaagtt
     9661 tagctgcagc caattcgatt tcttttcgac tttgtttggc agtagaatgt tgaccaatag
     9721 aattagcagt aagttgtggt gttgatgagg tggatatact aaaaaatgag gaggaaattg
     9781 ataattactt cacctagcta aaagttcaac gaattaggga gacattaggt agcctcatat
     9841 tactttgatt agtttttgct ataacattgt caaatatgat gacaaaaaaa tccgtccgca
     9901 cttttttacg agtaggacga attaaatatg ttatacaaac catcagcttt ttaacaattc
     9961 tacataaggt agttgttgat gcaactacct tttttctatg ctgattagaa caaatttgac
    10021 atggctacaa ctgcgattat ctgatataga gtattatata aactgattcc tcctacccct
    10081 tatccacaat tttaatacgg ctactgccat cgtgcgactt gatgataact agttgctgag
    10141 caataccttc tttcatatcg tctacgtggc tgatgacacc gaccatgcgg ttttcaccga
    10201 tttgttccag aacagaaatg gccttggtca gggcttcctt atccagtgag ccaaaccctt
    10261 catcgatgaa gagagcttca acaacggcac ccttgctggt attttggaca acttctgaga
    10321 gggatagggc aatggccagt gcagcgataa aggtttcacc accagacaag gatttaacgg
    10381 agcgttcact acctgtcagc tggtcataga cgttgatatc caaaccgaag tgatcacgcg
    10441 ccctgcgtcc ttcctcactt agaacaaagg aatagcggtt atccgttaat agtccgatgt
    10501 agttagcatt ggcatagtcc aagatttgtt ggaaatactg acggataacg tagacctcaa
    10561 gattaagacg accagttaga gcagtatttt ctcccttaac caccttaacc aaatcactga
    10621 gttcttggtg ggccttaaag gcctcttggt tactgtcttg aagggtttta gccgcttggt
    10681 aggtagccgt cgcatcctta agtccctttt ccatgacaga aaactgagcg agctgcctat
    10741 catagatttc ctgacaattc tgtactgctt gcgctagact atcgagatct ggttgttctt
    10801 gattttggag aagctcttgc cccttatgaa tctgcgcctg taattcttgt ttgagcgttg
    10861 cataggtcgt taatttggcc tgaagcatag gaatagcttg attatttacc tcaataagcc
    10921 agagttcgac ctgctctaag tcattagcga gggctccttc agccttgaga ctttgctcta
    10981 attcagcaga taatcgctta acatcttgat ttaccttatc tttagactta gttatactct
    11041 caatctgccc ctttattcct ttaatgtcgg catgaagttg gttgtaggct tcgctatttt
    11101 ccttgacttg cttattgtag aggttcagct cctgatgagc aagggaaatc cgttcttgat
    11161 atacctcaac agactcaagt tctggatgag cttcctgcag gtcctctagg cgttcttgag
    11221 cttggtcaag cactgccttg gcctcttgat aggttttagc caaatctgtc gctttttttt
    11281 gagccttacc tagctcatct tgatatcgga tataatctgt ctcttcctta tcataacgtt
    11341 tttgtaactc ttgataatac tgctcaacct tcaggagtag ggcttgccca cggtcagttt
    11401 catagtctat cgaaaaatca aaatcaaacc gtcccttaac gtgctcttct aattcttgat
    11461 agtgcttttc aagagttgcc ttgactttag ccacttggtc aagcaaatcc tgacgtttag
    11521 atgcaacttc actcaaggta gcctgacgat ttgataaagt agcgacttgc ttttcttttt
    11581 gagcttgaag cttctccacc tgatccatga gatttttcaa ggccacttca tcagcctgtg
    11641 ctccaccaac attagggtgt tccagagcac cacaaaccat acaaggatgc ccctcctcta
    11701 actctgcctg cagttggaca ataatgagtt gacggcgtga aaccaaagtc cttcttaact
    11761 cctcttccaa ttctttgaga atttcttgag cttgatcaat atcaaaagat aacgtttgat
    11821 gacgtttttc ggtctttgtc aactcctgat tcaagttctc tatttctttc aggtcctgag
    11881 caagttgatt ctccacactg tagcccacaa tctggaagag tttttcggcc tcatgtaaac
    11941 tatctaaact aagacgatta gcctccaagt cagacaagga cttgttaagc atctcaacct
    12001 cttttctagc ctgctgatag gtctcttcca actgcttgta gttagtcgtt gaacgtttga
    12061 ttttctcctg ttcttgggca agactctggg catagataat attctctttc caagtttcaa
    12121 gctcctcttc tttttgaaga aaatccttag attgaactgt gagttcctct tttttagcct
    12181 taacatcctc aaacgcctgt tgcttttcac ttaaggcttc ttgagcaatt tcaaggtcct
    12241 gctctaattg catcaactgt ttccgatact gcttcaaggt ccgaatggtt tcctgcagac
    12301 cttgagcaaa ctgtaattcc tccagatgca cttttgcctc tgcctgtcct tgagccccct
    12361 cctcaatttc cagacggtaa cgttccttgg cttgctccaa ttcttgaaaa atctttgcca
    12421 aatcttgggc agtttgcaag ctcttctgca gttgtgccaa atcctcgtgg gcagccttca
    12481 agatactttt ttgcttcgta acattttctt gacgctgaga caaaaactct tcaagacgtg
    12541 tcaatttttc agaggctggc gtttgctcca agacggataa ttcttcctca gaccaaacct
    12601 gactggcaaa atgaccatct agctgagcct gacgcttttc catatcctta ttactctgac
    12661 gaagacgctc ttccaagctc ttttgaaaat ggtcaaaaat acccgttcca aagattttct
    12721 ttaaaatttg agtcttggtc ttagaatctt ctttcaagaa acggctgaaa tcattttgtg
    12781 gaaggagaat aatctgtttg aactgctcag cattgagccc caaaatctgc tcaatctggt
    12841 cactcacttc cttgatctta tccccaagct tttcaatttc ctgaccacca atcttatcca
    12901 caatgactag agaagccgtc gccttttgca tggtagtgcc cccaccctgc ttggccctct
    12961 cttgctggag aactcggtca atgcgataaa ggtgattgcc ttgttggaaa tagaaagtca
    13021 ccttggtcaa atcatcctct ggaccagcga aagttgaccg catctcctca acattacgat
    13081 caccactggt cgtagcaaac aaggctaccg tcatggcatc aaagagagta ctcttaccag
    13141 cccctgtatc ccctccaatc aaaaagaggg gagcatggtc aaactgagtg aaattaataa
    13201 cttccttacg atatggtcca aaattggtca attctaactg gactggtctc attgtcgact
    13261 cctctcaatc tcctcaaaaa cactttccac aagggcagtc tgtctctcag ataagacatc
    13321 gcccccagtt actgtctggt aaaaatcaaa tacgatttcc tggggcgact gcatttccaa
    13381 atcttttaag tgctgatcaa cggtcaagtt ttcttcccta acatcaccca gacgactgaa
    13441 agtaatttct acaatgtctg tcccataaat ctcttccagt cgggcacgca cattgatacc
    13501 ctctaattcc ttacgactag acagttgaat atcaaaggcg aaccaggctt tttgacaagg
    13561 ttgattctta taaaattcag gtgacatcaa ggtttcaaaa gattcctgta aagccacaat
    13621 cggccgttta acctctagag tatggaaggt ctgagacata tcaccagacg catccaattc
    13681 aagaatatag acaccctttt cttccttacg cttggcttct ttgacattaa aggcgactgg
    13741 actgcctgaa tattgcacgc gcttggtagg actagcaaaa cgcgtatgga tatgccctaa
    13801 ggcaacataa tcgaaagact tgaaaaggtc actggtcaca ttggtaagac cacctaccgt
    13861 attactggtt tcagacaaca tcaattctcg aagaccctga ccatcgctat catccttctt
    13921 agaaaccgca aaatgcgtca ccaagacatg agctttgtca ggatcaaaag ctttttccat
    13981 atcctcaaga atgtaggtca aggcatcacc aatcccctga atttcctttc cctcatcatc
    14041 cttatagtaa atacgagcat caataggatc gataaaaggc agcagaaaaa tctggcaatt
    14101 ctccaactca atgggctcaa aagcctcctc caaacgtgta cttaaatgaa ggccctgatg
    14161 ttgaaagaag tcacgcccaa aatgtaaacg ttcagcccca tcgtgattac cactaatcgc
    14221 atagacagga atctgctcct ccagtaccaa gcgggccaag gtcttattaa aaagcttaat
    14281 cgcatccaca gggggcaccg cacggtcata gaggtcccca gaaatgataa ccccatccac
    14341 tttttcgcta atagccaaat ccacaatttg ttgaaaagcc cactcctgct cctccaacaa
    14401 agaccagcca ttgagggttc gtcctacatg ccaatctgac gtatgtaaaa acttcatgac
    14461 aacctcctca ttcattttgt cttacttcta ttgtacctta tcaagctaaa tactgcttaa
    14521 aagtttcaca ggctttgata gttttcccgt tttttagctg taaagatcaa aaaatctctc
    14581 ccaagctatc ctgtactgac cccaaaaagt tagacaattt atgtaagcaa aggatttagc
    14641 tctgtattgc acaggattga gtccttttag ttttacctta atgcatttgt tgttgtagta
    14701 atcaatatag tctagattac cctgcctcaa ttggttaagt aatttaaata cctctaacca
    14761 agaaaatcaa tattatctat tcttttaatt gacttttata gattctaagc attatcatat
    14821 aggttggtac tagtgcacat cttgtatttt aggcaataat atttactcac ttttcgttat
    14881 tgtcagtacc gatccttttt aaatttttca ctatgaaaac ctaaaaataa tccgaaccct
    14941 aagggctcct gactttttac tttattctag gcttttttta tccgtagctt gttagctgac
    15001 ttggaactag gcatgtagta tttactattt ccctacttga gattttttat aagtcacatg
    15061 cattattcca tctgaacgaa tggtatgatt tttatttctt ttagagaaac accggtaata
    15121 gctaattcct atcttaaatc acttgaaata tatttataat gtgttggagt gctaatcagt
    15181 accgcttgta gatttttgga agatactaac acactaatga tttaatctcc tttaaaacat
    15241 gaaaagagaa gcctccaaag cttctctttt ataattatca aataatgtac aactagattc
    15301 ttaataacta cctaatttag tggttcaatc atgaagctta attgatagct atctgctgag
    15361 ctaagcaaga attcgtcatg aactggagca ccccatgtgt cgtcaccacc tacacccatt
    15421 tgagcagcaa gaactttaat ccatgtagca tcagattctt gcaactcata ttggtgacga
    15481 gcattttcaa tttgttcagt actgttacgc aaagcactga attcgaatgc tttattaagt
    15541 gcggtgaatt taagaccatt atggttatca tcagatactg tgaattcacg agtaccatag
    15601 tgattaccag attcttgtgg cattagatat ggagcaaatg tcttttcaac agatgtttca
    15661 tatcgaccaa gataggcacc aggaagttta tcacggtagc tttcttctgc accgtatcca
    15721 taatagctaa ggtttgtaaa ttgtgaaccg atagcaaatt ctagaccaaa ttcagggaag
    15781 tttggcaaac ctgctttacc atcatagttt gcagtaacaa agattcgacc cttgtaatca
    15841 acttgataag ttaccttaac ttcgacatca gacaagcctg gcaattcatg aacataagtc
    15901 actttaacag agtcgtcttc gatttgaatt tgagtatctg taactttact atagtttcca
    15961 gcaaccttcc agcctgccat ttcgaatgga tatccagcac cacgatcgtt gtcagtgtaa
    16021 gcacgagtga agctaagttt aggacctttc tcaatgaatt caacaccatt atacttagca
    16081 gatactaaag tattttgtgc acgtgaaagc aagattgaga agttttgtcc ttgaataccg
    16141 atgttgaagt cgccttcaac aacattcaaa ggtgctttaa ctggtgtttc agtgctaatc
    16201 ttttcaacaa catattgacc acgaacaatt tcatgacctt taggagccca ttcagttgct
    16261 tccctcagaa cacaagcaac ttcgtaaatt tgttcagaat ttgaagcctc gactacaaag
    16321 ttaactggga atgttgcttc ttcgcctggt ttaacatcaa agtgatattc actttcacta
    16381 acttttctac catcttcgta aactctagct aggaaagtat aagcagaaag atcttcgaag
    16441 agattatcat tcttgatagt tactgatttt tcatcaacag caatcttaat attagagtaa
    16501 agatgtttaa ctgtttgaag ttttggagtt agggtacgat ctgcaaagac gataccattt
    16561 ccacaaaatt cgtagtcaga aggtctatca tgccagtcac caccatatga taggaattcg
    16621 ctaccatttg gaagtgtttt gtaaatagct tggtcaatga agtcccaaat aaatccacct
    16681 tggtattctg gatatttctc taagtcagtg tagagttgca atccaccacc agagttaccc
    16741 attatgtgca tgtattcaca tgaaatataa ggtttttgag gtttgttagt taggttacct
    16801 gaagcaaagt gtttatcact aacgcttgaa agatcaacta gtttaccagt tgtgaggtat
    16861 tcttcgatat cagctggttt cgcatacata cgactttcga tgtctgtaat gtaatcaaac
    16921 tcacgacacc atgcaacacc ttcatagtga actggacgag tattgtcaac actacggaag
    16981 taatcagcca tgtcagcaat atctttacca gcatatgatt cattaccaca agacc
//
