LOCUS       gnlProkkaEOGNBIFH_136  17037 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EOGNBIFH_136.
ACCESSION   gnlProkkaEOGNBIFH_136
VERSION     gnlProkkaEOGNBIFH_136
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 13:59:25
            Original ID  :: gnl|Prokka|EOGNBIFH_136
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17037
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17037
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4612:7037]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4613..7037
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17037
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17037
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             161..274
                     /locus_tag="ctg81_1"
                     /transl_table=11
                     /translation="MPTKIWLKPEQLDLYIKHLERFRDLYSKLDCSGIVNL"
     CDS             503..604
                     /locus_tag="ctg81_2"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             774..1043
                     /locus_tag="ctg81_3"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1203..1502
                     /locus_tag="ctg81_4"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1602..2513)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg81_5"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2743..2832)
                     /locus_tag="ctg81_6"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2829..3431)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_7"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.2e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3525..4616)
                     /locus_tag="ctg81_8"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4613..5932)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_9"
                     /sec_met_domain="Streptide_RRE (E-value: 9.3e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.6e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.4e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.6e-07, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNVFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6002..6094)
                     /locus_tag="ctg81_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6177..7037)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg81_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.7e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7277..8113)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg81_12"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8107..8673)
                     /locus_tag="ctg81_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8852..9010)
                     /locus_tag="ctg81_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9022..9153)
                     /locus_tag="ctg81_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9163..9675)
                     /locus_tag="ctg81_16"
                     /transl_table=11
                     /translation="MAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             complement(10075..13254)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 497.2; E-value: 1.7e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg81_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13251..14459)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg81_18"
                     /sec_met_domain="Metallophos_2 (E-value: 4.1e-10, bitscore:
                     31.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 tgacggtaaa atgacaatcc tggagaagta atttaattta tgactaaaaa tcagcaaaaa
       61 tataattatg actaaggaat attttattaa ctaaatgttg agatagcaca aggaaatatt
      121 tgtgctatct tttttattta ttaggaaaag agaaaaaatt atgccaacga aaatatggtt
      181 aaaaccagaa caattagatt tgtatattaa acatttagaa cgatttagag acttatatag
      241 taaactagac tgttctggta tagtaaattt gtaacactcc tacctaataa gttaaactat
      301 tcattagaat aggagacata acatgaaaca ctatccagac gaaacacgat aaaaaattgt
      361 tcgactgcac attcaagacg gatgaacatt aaaaagctta gctgctgaat atggcgtatc
      421 ccaagcctca atctctaatt gggtaagaca ttatcgcaaa gaatgccaaa ctaataataa
      481 agaaaaatca cagcttgaac tcatggagga ggttcgtaaa ttacgtcaag aaaaggcaga
      541 gcttgaaaag gaaaatgatt tcttaaaaaa agcagcggca ttctttgcaa aggaaatcga
      601 ttagaggcat atcgttttat tgataactat aaagaagatt ttggtttgcg ttggttgttc
      661 ttgcatatga atattcatcc caatgcttat tataattatc ttaaaaagac aaggactaac
      721 tatcatcgtc aaaagaaagc tattcttaat actattcgag atatctacca tgagtgcaat
      781 ggaaagaagt aaatcaattc ttcgaaacag aaagcatcaa actttctgat atagagcctt
      841 cgaaagttag ttatagggag gtacaaagga atcaaatcaa taccactatt tataatgaaa
      901 aaggtaatat aaaggatatt gatactagca ttataagaga tatgtacgat aaaagcaaac
      961 ctactttaaa acagggagcc tatatatccg ctatagcagc ttctctagaa ggggggtact
     1021 gcatttataa cagcaataat taaaaaaagc gcttagggaa aactattagt gagtttacaa
     1081 aagacgattg tcttgaaatt tctaaagata gtggaattgg agctataaaa ggaagtactc
     1141 gaggcattac gatatacgcc ctaacgaatt acacagctac tcctgcagca gtagcaagtt
     1201 cattgtgcac tgcttcattt ggtatcgcta aagaagcata caaattccgt aaaaacttaa
     1261 tcacaaaaga agaattttta ctaaattcgc aaatattatg tgttgaagta tcagttagtg
     1321 cattatcctc aatattagga catgctgtaa ttccaatacc tattttagga tccgttattg
     1381 gaaataatat aggaactttc ctatatgaaa tcgctaaaga taatctcaca atgaaagaga
     1441 aattactgat agcagattat ttcaaagaga tacaagaata taactatttt ttagataatt
     1501 aatttgaatt atataatcat caacttcaga gagattaaga attactataa acttttaggg
     1561 aaggcatttt ctcctgacta taatatcgct tttcagggat cttatgaatt tttaaatatg
     1621 ttttttaaaa atacgttaac ctctcctatt ttctctgctt caggtaaata gatagaaacg
     1681 gttgtcgaat aaacaaaaga aggtacactc acaattgaaa gcaattgact aataactgca
     1741 taaatagcca acaattctac tcctaatctc gacatcaagg catcaaacac cataataaac
     1801 aaaacactct ccagaatttc ttgaccaacc aaaggaatac caaatgttat taattcaaat
     1861 ttagttgtag atgtaatgga taaagccttc aaaatcattg gataaaccat aaacaagtaa
     1921 ctaagcgata tgaaagctaa ggatacaatc gttgatatgg ctgctccctt aattccgatt
     1981 tgtggtacca gtacataatt taacacaaca tctattaatg aactgataag tccaacccac
     2041 ataattggtt ttgttttctt ttgaactctt aataaatttg tcagcgaaaa gtttaataat
     2101 gtcaatccga tatatggaga catgaagact aaataaatgg tggataagga caatagttgc
     2161 cctttaaatc catagagctg cttcaagatt acatttccaa aaataatgac aaaaaccgca
     2221 aaggcaactc cgataattaa atctaaggtt agatttgatt tcaataaatc atcaaacctg
     2281 ttagtttgcc gattagagta cgccttagag cttttaatat taaatgacaa actgaatgct
     2341 cctaaaagtc caccaaaagc aaataagaga ttctgaataa tggaaattcc tgacagagca
     2401 attgaggaat tgttcacagc aaaatgcaat gctatctgcc caataattac ttgaccaata
     2461 tttgttaaaa ctaagggaaa ggcaaatttg ttaatttctt ttgaatctat catttttcct
     2521 ctctaaaagg cttcaaatgt aagtaaagat cagatttaac taaatttgca taaataatat
     2581 gcaaaatagg agtttcttct aaaaatgaaa taattgcctg cttacaatca ttagcagata
     2641 cctcataatc ttgctgtaat agttctacaa tcttgtctaa agaaaaattt ttagaaatgc
     2701 aataaagtat ttctgctcct atttcatcaa atgaatagta ctctaatcaa gtagatcgta
     2761 tcctatgtat tcatctgcta ctttatttac aatgaaatct ctcttacctc ttatcacaaa
     2821 atgttctttc atacgactac tccacctcct ttttgttcat aaaagcaggc taaatcagag
     2881 cccagtaacg ttccatctaa ttccaaggca ctgcatcgac atcccccacc acaccatggt
     2941 aggggacatt ctgaacattt cccagaaata tcatcaaatg taattgatct tagtttatta
     3001 aatacagcag aatggtgcca aatttcgcta aacttttgtt ctttaacatt tccagcaact
     3061 aattcatcta taccattcat caagtcacac ccgtatacat ctcctttatg attaattgaa
     3121 catgctctaa ctccagcttg acaagatatt tcccttggct tatcaaaatt tatatctact
     3181 ttttgatgcc aaacattttc taataaatct gatctattat aaaatgcaag cggaaaataa
     3241 tgtgtcaaaa aaacatcact ttcattagga ggaacaattt taaatttaac tttgaactct
     3301 cctttagaaa tccgctctgt taaatcaaga aaaacaggat accattgttt tttatctgct
     3361 aaaatactac cgtcattagc cctaccagta ggacaaataa ccataactga catatactca
     3421 ataccaagca tatcattcaa tcttatactc taaagaaaat atctgctaaa tttgcaaaca
     3481 attgtgctat caataatttg gcaaatgaat tagaaataca acttttaagt tcttttctct
     3541 ctgttagaaa atgaataaga tactaagcaa caaagagcta ctataccaaa tattaaataa
     3601 ttgctcctaa tactaaagtt atcagcaaaa ataccagcta ggaaatcagc taacataaaa
     3661 ctaatcgaaa taaacaaatt atatactgac catgatactg ctctattttt ttctattgac
     3721 atattaaatt tataataaaa atgattattg tagttggaat taagaacacg cattaataaa
     3781 aggattataa tttggatgat tagattagtt tgaaaaaaca tgagtatagc taatactggt
     3841 aacatcaagc ttacttcaaa cttaattttt agataactcc ccaaagccat agatatatta
     3901 aacataaata gtataattcc cagcatatct agtgaaagtc cctgttcatt taagaatatc
     3961 cctgcataag aattgctaat cataattaga gttgagaatg ctactcctaa tattattaat
     4021 aaccatggaa tattttgaat attatcgagg ctaaaaaatt tttgtttatt attttgttcc
     4081 tttttaatct cgggtaatcc tattaaatat aataaactga aaattacaaa tacaatggat
     4141 ataataatag gataaatata attcctatgc aataaaggtg gagatataat cgtaataata
     4201 gcaataaaaa tatattttaa tgtgttgaga tttttcaaaa atgatttata tacaacttcg
     4261 tcatcaatta tttcaaaatt ataagaaata agaactcctg aagataatga ttctgacaat
     4321 ccaaaaaata tcgctgaaat atatattata tttgattttc caaacaatag gccccataat
     4381 gctaaaatta ataataaatt tgaaatagcc aaaattttct tgtaaccaat cttacttgaa
     4441 atataactta aaggaatatc aaaaactgag ccacatagct cagtaataac tgataaagta
     4501 gctatttctg tgaacgaaaa acctaagtgc tttaatagta aaattcctac aaagtagtac
     4561 ggtaatccag atagaaacat attcattccg tataaattaa aaatcttctt actcataagt
     4621 tacaaactgg gtctctaaaa tattttggac tcttctcctt aatcaagtta acatagcagc
     4681 caccctcgca aatttttaac aatccacaag ataaacactt agaattcttc gttctaaaag
     4741 aacgaatccc tccatacaac ggatcatcat accaaacatc taacaaatct ttttcaaaga
     4801 cattctgctt agtttgatta actcctaaaa aagcaatgca aggcaagata tccccattag
     4861 acattatttc catcttagta tattttgcac gacatccata atacatttcg ccaaactctg
     4921 aaaattcaat tgaattattt atcaactccg gataagcggt gaaaagatga catccctcag
     4981 tagcaaaatt taaattagct tcccgttgag ttatataatc tgtaacatac tcattcaacc
     5041 ttctcaaatc agctaaatcg tattttttct ttattttcgt atatcctgtt acctcagaat
     5101 aattagctac tgaaaatcta tctattttat tctctataca aaaatcaacc aattctataa
     5161 tctgctcata gctttgcttt gtatacactg cattaattct acattttttt ccaacctctt
     5221 taaagtactt cgctaattta atttgtctat caggtctcac ccccattaat tcaaaattta
     5281 atttaggatc taaagtctgc aaagataaaa ccggtgtaat atatttagat ttagctagaa
     5341 tttccactgt acttttcttt attaattggg cattagttgt tatagtagtc tttatcttca
     5401 gttcttcaca agctatcaac aaattatcaa tatcaaaata tctagtcggt tcccctccta
     5461 aaattgaaac acttaacact ccattatctt ttgcttggcg caaaattctt tcccaatctt
     5521 tagcaggttt ggcatttcta tcttcacgat ttgctaaaaa acaaaaacca cattttaaat
     5581 cacagtacat actggggtat attactagtt caagcggaaa actcaatatg ttatgttttt
     5641 ttaattttgc tacatgcttt ctcgcatttt gaagagtctc gtcaggattt ttcgatgatc
     5701 cctcaatatt attatcagaa tagatattta ataagagtac tcgctctagt ttccctgctt
     5761 ttatttcttt cttaaaaaag gacgtagcaa tttcaaaacc atgattttga accaaataaa
     5821 gaaaataagc ttcactctca tctaactcaa ttcggtcaaa agttacttta tttatcaaaa
     5881 ttccaccaaa cttttctagt ctaaataaaa aatcttctga aattgtcatc atattgaata
     5941 cctttctaaa aaagcagagg aaaatatagc ctctgcttaa cttatgggat aaattacttt
     6001 atcactccca gccgtcacct tttgccatca ccttccagcc gtcacctttt gccattgaac
     6061 tagactcaag gactttttca agctctttag acatatttgg tactcctttc gaatatgata
     6121 ctgtgattat atttcttttc aacacttaca ataaaatatt cccatatttg cattttctaa
     6181 ctactagcta aaattttttc taaatgtcct tcataagtct ttgctaagtg atgacttcct
     6241 gctaatttca tcgctccaac acacttcttc atttcaataa ttgctttcac atttccatcc
     6301 tctttatatt gataaagatt ttgtgcatac ttaaagacta aacgttcata tacttctgtc
     6361 tcaataaaaa agcattgatt tagctgcttt tcaaaatata aagcatccat aaatttttct
     6421 ctttcaacac atgtaatata tccatttaaa agcatcgttg aaattaatcg tctgttattt
     6481 ggaatttctt tgtaaaaatc agaacgccta aacatttctc ttgctaagac catgaaaaca
     6541 tcatgattta atacatctaa agtattcgag aaaatcaata actcatagta cccccagtat
     6601 tctacactaa agagataatc tgttaaatat gtcaaatcat cctttgtata gtaagtttct
     6661 cctgataaat cctgtagacg aattttcaat aaaataatat tgatttgatg aaatttttct
     6721 cgcctatctt ccagttccat ctgagaataa agtaattttt tcataccttc tacgtcacgt
     6781 gttgacacaa aatgacgtac tttcgataac agttcgttta actcatctct atgaaaatca
     6841 tggaccgcat acataaattc atctattggc atattgattt catctaaaat aaacatgaac
     6901 tttgaaatcg ttaaatctgt ttctcctttc tcaaatcgag agagctgaga cgttgatata
     6961 ccagcctttg cgacgtcttt taatcgtaat cctctcgatt ctcgaaactt tttaaaaatt
     7021 tctccaaatt ttttcatact acacctccat cacgcatata tgggaataat tttcatttgc
     7081 tttcatcata tcatacaata aagaaaaaca aaagtgagga ttatcacatg aaaaagcaaa
     7141 ttttactaac acttcttctt gtcgtatttg aaggcattat cgttatcgtc gtgggataaa
     7201 gagtctggga caaaagtcct ttagctccaa aaagcaacgg cataatgtac tgaccccaaa
     7261 aagttagaca aataatttaa gtaaaggatt tagttctgta ttgtacagga ctgagtcctt
     7321 ttagttttac cttaatgcgt ttgttgttgt aataattaat atagtctgca attgcttgtt
     7381 ccaaatgctc aattgactta aacgtcttct cataaccata aaacatctca gacttaagaa
     7441 tgccaaagaa ggattccatc atgccgttgt ctggactatt gcctttacgt gacatggatg
     7501 gttggattcc tttctcctct aaaaaatgat gatagaaatc atgttgatat tgccatccct
     7561 ggtcactatg gagaattgta tttttgtaat gtttctctgt aaaggcttgt tctaacatag
     7621 ctttcacttg tatcaagttc ggtgacttag aaagattgta ggcgataatt tcactattga
     7681 agccatctaa aattggcgac aaatagagtt tttggctgct tgctggaatg gcaaattctg
     7741 ttacatctgt gtagcatttt tccaatggtt tggatgcttc gaactggcgt tggatgagat
     7801 tctctgcttt cataccaacc tctccttgat atgaagaata cttacgttta cggcgaattc
     7861 tagcggttaa accaagtact ttcataagac gttgaactct cttatgatta atcacaattc
     7921 ctcgatttct caattcaaga gtcattcgac gatagccgta atttccttta tgctcagtaa
     7981 aaatggcttg aatttcagct ttaatgtcat aatccttatc attttgatcc agctgtttta
     8041 agtggtaata ataggttgaa cgagcaagct taataatctt tagaagcata tctaaagaaa
     8101 actcagttac caatcctcgg acaatttccg tttttcttct tgctcttttt cttccctcaa
     8161 tcggagttct ctcaactttt taagaactgc attctccgct ctaaggtact cattttctgc
     8221 ttgaagacgt tccatttctt ccagtttttt ctttggctta cgtcccattt tagataacct
     8281 tcctcttgtt ttctcaacaa tagtataccc gtttttctta tagtgtgcga gccagttagg
     8341 aagcgtccca cgatttggga gagcatattc aagagaaact ctatcttgag aatagccttt
     8401 atataggact ttatcaatca tttcttgttt taattcagga gagtagtaac gattctttcc
     8461 ttttttagcg atttctattc cgtatcgatc aatcaattta atcatgtagc taagattaga
     8521 aatgtttatc ccaaatttat ttgaaagctg atctaagcta tatccttggt ttctaagttc
     8581 atagatttga accttatctt cataagtcaa tttcataata aaaacacccc gaaagttaga
     8641 ttttttctgt ctaacttttg gggtgcagtt cataaaaccg ttgctttttg catgattgtg
     8701 atagacttgg tgaaatagaa ttgaccaaaa atcttctgaa atataacaag agagtgactc
     8761 gaatttaaaa agctagagtt ccacaattgg aaatctctag cttttttgtg actgagaact
     8821 ttttgtccca gcctctactt tctactgact actatcctgc atgccctaag tcgagataga
     8881 gaatatctcg cttagtggca tactctagcg catgttcaac agcctcaaat aaatctgaag
     8941 ctagaaacct tttcgtaaag acggtttcgt ctttacgctt aaatttcgca acataactat
     9001 gtttagtcat tttttctcct tctaatattc atattgtcct ttaacaccac tatagatcca
     9061 gtaaactgct ttatcataaa cttgtttaaa ggagatacct aatcgattgg ctacatcaag
     9121 aattgaaatt tgcttacatt cctctatatt cataaaatat catcattttg tcgtagtatt
     9181 cggcaatgat ggaacagatg aggattcttc taaagtttta ggagttgcct tatctagatc
     9241 atctaaccca gatttccaaa cctgtacttg gttgaccaat aacttaccag gtagtttcga
     9301 atagttcaaa ttaaccgttc tggtttctgt ttggtttgtc tttgattggt tggcattctt
     9361 taaatcagat acataagtta cattataaga gaccatggca atggcttgat tcgtagtctg
     9421 attgacaaag atatctgctt tttcaaaatg ataatccaaa atatagtcct tatacacttg
     9481 gttcatggca tcattttgac ttgtcaattc ttgagaatag gccgattcag tcatataagg
     9541 ttgaatacgt gtattatttt cccctagttt ttctttcgta tagtactgtg tcaaaaattc
     9601 ttttacagta tctgatgata aaatacttgc tttatcttct gcttgtttgt cctctacaag
     9661 tttagctgca gccaattcga tttcttttcg actttgtttg gcagtagaat gttgaccaat
     9721 agaattagca gtaagttgtg gtgttgatga ggtggatata ctaaaaaatg aggaggaaat
     9781 tgataattac ttcacctagc taaaagttca acgaattagg gagacattag gtagcctcat
     9841 attactttga ttagtttttg ctataacatt gtcaaatatg atgacaaaaa aatccgtccg
     9901 cactttttta cgagtaggac gaattaaata tgttatacaa accatcagct ttttaacaat
     9961 tctacataag gtagttgttg atgcaactac cttttttcta tgctgattag aacaaatttg
    10021 acatggctac aactgcgatt atctgatata gagtattata taaactgatt cctcctaccc
    10081 cttatccaca attttaatac ggctactgcc atcgtgcgac ttgatgataa ctagttgctg
    10141 agcaatacct tctttcatat cgtctacgtg gctgatgaca ccgaccatgc ggttttcacc
    10201 gatttgttcc agaacagaaa tggccttggt cagggcttcc ttatccagtg agccaaaccc
    10261 ttcatcgatg aagagagctt caacaacggc acccttgctg gtattttgga caacttctga
    10321 gagggatagg gcaatggcca gtgcagcgat aaaggtttca ccaccagaca aggatttaac
    10381 ggagcgttca ctacctgtca gctggtcata gacgttgata tccaaaccga agtgatcacg
    10441 cgccctgcgt ccttcctcac ttagaacaaa ggaatagcgg ttatccgtta atagtccgat
    10501 gtagttagca ttggcatagt ccaagatttg ttggaaatac tgacggataa cgtagacctc
    10561 aagattaaga cgaccagtta gagcagtatt ttctccctta accaccttaa ccaaatcact
    10621 gagttcttgg tgggccttaa aggcctcttg gttactgtct tgaagggttt tagccgcttg
    10681 gtaggtagcc gtcgcatcct taagtccctt ttccatgaca gaaaactgag cgagctgcct
    10741 atcatagatt tcctgacaat tctgtactgc ttgcgctaga ctatcgagat ctggttgttc
    10801 ttgattttgg agaagctctt gccccttatg aatctgcgcc tgtaattctt gtttgagcgt
    10861 tgcataggtc gttaatttgg cctgaagcat aggaatagct tgattattta cctcaataag
    10921 ccagagttcg acctgctcta agtcattagc gagggctcct tcagccttga gactttgctc
    10981 taattcagca gataatcgct taacatcttg atttacctta tctttagact tagttatact
    11041 ctcaatctgc ccctttattc ctttaatgtc ggcatgaagt tggttgtagg cttcgctatt
    11101 ttccttgact tgcttattgt agaggttcag ctcctgatga gcaagggaaa tccgttcttg
    11161 atatacctca acagactcaa gttctggatg agcttcctgc aggtcctcta ggcgttcttg
    11221 agcttggtca agcactgcct tggcctcttg ataggtttta gccaaatctg tcgctttttt
    11281 ttgagcctta cctagctcat cttgatatcg gatataatct gtctcttcct tatcataacg
    11341 tttttgtaac tcttgataat actgctcaac cttcaggagt agggcttgcc cacggtcagt
    11401 ttcatagtct atcgaaaaat caaaatcaaa ccgtccctta acgtgctctt ctaattcttg
    11461 atagtgcttt tcaagagttg ccttgacttt agccacttgg tcaagcaaat cctgacgttt
    11521 agatgcaact tcactcaagg tagcctgacg atttgataaa gtagcgactt gcttttcttt
    11581 ttgagcttga agcttctcca cctgatccat gagatttttc aaggccactt catcagcctg
    11641 tgctccacca acattagggt gttccagagc accacaaacc atacaaggat gcccctcctc
    11701 taactctgcc tgcagttgga caataatgag ttgacggcgt gaaaccaaag tccttcttaa
    11761 ctcctcttcc aattctttga gaatttcttg agcttgatca atatcaaaag ataacgtttg
    11821 atgacgtttt tcggtctttg tcaactcctg attcaagttc tctatttctt tcaggtcctg
    11881 agcaagttga ttctccacac tgtagcccac aatctggaag agtttttcgg cctcatgtaa
    11941 actatctaaa ctaagacgat tagcctccaa gtcagacaag gacttgttaa gcatctcaac
    12001 ctcttttcta gcctgctgat aggtctcttc caactgcttg tagttagtcg ttgaacgttt
    12061 gattttctcc tgttcttggg caagactctg ggcatagata atattctctt tccaagtttc
    12121 aagctcctct tctttttgaa gaaaatcctt agattgaact gtgagttcct cttttttagc
    12181 cttaacatcc tcaaacgcct gttgcttttc acttaaggct tcttgagcaa tttcaaggtc
    12241 ctgctctaat tgcatcaact gtttccgata ctgcttcaag gtccgaatgg tttcctgcag
    12301 accttgagca aactgtaatt cctccagatg cacttttgcc tctgcctgtc cttgagcccc
    12361 ctcctcaatt tccagacggt aacgttcctt ggcttgctcc aattcttgaa aaatctttgc
    12421 caaatcttgg gcagtttgca agctcttctg cagttgtgcc aaatcctcgt gggcagcctt
    12481 caagatactt ttttgcttcg taacattttc ttgacgctga gacaaaaact cttcaagacg
    12541 tgtcaatttt tcagaggctg gcgtttgctc caagacggat aattcttcct cagaccaaac
    12601 ctgactggca aaatgaccat ctagctgagc ctgacgcttt tccatatcct tattactctg
    12661 acgaagacgc tcttccaagc tcttttgaaa atggtcaaaa atacccgttc caaagatttt
    12721 ctttaaaatt tgagtcttgg tcttagaatc ttctttcaag aaacggctga aatcattttg
    12781 tggaaggaga ataatctgtt tgaactgctc agcattgagc cccaaaatct gctcaatctg
    12841 gtcactcact tccttgatct tatccccaag cttttcaatt tcctgaccac caatcttatc
    12901 cacaatgact agagaagccg tcgccttttg catggtagtg cccccaccct gcttggccct
    12961 ctcttgctgg agaactcggt caatgcgata aaggtgattg ccttgttgga aatagaaagt
    13021 caccttggtc aaatcatcct ctggaccagc gaaagttgac cgcatctcct caacattacg
    13081 atcaccactg gtcgtagcaa acaaggctac cgtcatggca tcaaagagag tactcttacc
    13141 agcccctgta tcccctccaa tcaaaaagag gggagcatgg tcaaactgag tgaaattaat
    13201 aacttcctta cgatatggtc caaaattggt caattctaac tggactggtc tcattgtcga
    13261 ctcctctcaa tctcctcaaa aacactttcc acaagggcag tctgtctctc agataagaca
    13321 tcgcccccag ttactgtctg gtaaaaatca aatacgattt cctggggcga ctgcatttcc
    13381 aaatctttta agtgctgatc aacggtcaag ttttcttccc taacatcacc cagacgactg
    13441 aaagtaattt ctacaatgtc tgtcccataa atctcttcca gtcgggcacg cacattgata
    13501 ccctctaatt ccttacgact agacagttga atatcaaagg cgaaccaggc tttttgacaa
    13561 ggttgattct tataaaattc aggtgacatc aaggtttcaa aagattcctg taaagccaca
    13621 atcggccgtt taacctctag agtatggaag gtctgagaca tatcaccaga cgcatccaat
    13681 tcaagaatat agacaccctt ttcttcctta cgcttggctt ctttgacatt aaaggcgact
    13741 ggactgcctg aatattgcac gcgcttggta ggactagcaa aacgcgtatg gatatgccct
    13801 aaggcaacat aatcgaaaga cttgaaaagg tcactggtca cattggtaag accacctacc
    13861 gtattactgg tttcagacaa catcaattct cgaagaccct gaccatcgct atcatccttc
    13921 ttagaaaccg caaaatgcgt caccaagaca tgagctttgt caggatcaaa agctttttcc
    13981 atatcctcaa gaatgtaggt caaggcatca ccaatcccct gaatttcctt tccctcatca
    14041 tccttatagt aaatacgagc atcaatagga tcgataaaag gcagcagaaa aatctggcaa
    14101 ttctccaact caatgggctc aaaagcctcc tccaaacgtg tacttaaatg aaggccctga
    14161 tgttgaaaga agtcacgccc aaaatgtaaa cgttcagccc catcgtgatt accactaatc
    14221 gcatagacag gaatctgctc ctccagtacc aagcgggcca aggtcttatt aaaaagctta
    14281 atcgcatcca cagggggcac cgcacggtca tagaggtccc cagaaatgat aaccccatcc
    14341 actttttcgc taatagccaa atccacaatt tgttgaaaag cccactcctg ctcctccaac
    14401 aaagaccagc cattgagggt tcgtcctaca tgccaatctg acgtatgtaa aaacttcatg
    14461 acaacctcct cattcatttt gtcttacttc tattgtacct tatcaagcta aatactgctt
    14521 aaaagtttca caggctttga tagttttccc gttttttagc tgtaaagatc aaaaaatctc
    14581 tcccaagcta tcctgtactg accccaaaaa gttagacaat ttatgtaagc aaaggattta
    14641 gctctgtatt gcacaggatt gagtcctttt agttttacct taatgcattt gttgttgtag
    14701 taatcaatat agtctagatt accctgcctc aattggttaa gtaatttaaa tacctctaac
    14761 caagaaaatc aatattatct attcttttaa ttgactttta tagattctaa gcattatcat
    14821 ataggttggt actagtgcac atcttgtatt ttaggcaata atatttactc acttttcgtt
    14881 attgtcagta ccgatccttt ttaaattttt cactatgaaa acctaaaaat aatccgaacc
    14941 ctaagggctc ctgacttttt actttattct aggctttttt tatccgtagc ttgttagctg
    15001 acttggaact aggcatgtag tatttactat ttccctactt gagatttttt ataagtcaca
    15061 tgcattattc catctgaacg aatggtatga tttttatttc ttttagagaa acaccggtaa
    15121 tagctaattc ctatcttaaa tcacttgaaa tatatttata atgtgttgga gtgctaatca
    15181 gtaccgcttg tagatttttg gaagatacta acacactaat gatttaatct cctttaaaac
    15241 atgaaaagag aagcctccaa agcttctctt ttataattat caaataatgt acaactagat
    15301 tcttaataac tacctaattt agtggttcaa tcatgaagct taattgatag ctatctgctg
    15361 agctaagcaa gaattcgtca tgaactggag caccccatgt gtcgtcacca cctacaccca
    15421 tttgagcagc aagaacttta atccatgtag catcagattc ttgcaactca tattggtgac
    15481 gagcattttc aatttgttca gtactgttac gcaaagcact gaattcgaat gctttattaa
    15541 gtgcggtgaa tttaagacca ttatggttat catcagatac tgtgaattca cgagtaccat
    15601 agtgattacc agattcttgt ggcattagat atggagcaaa tgtcttttca acagatgttt
    15661 catatcgacc aagataggca ccaggaagtt tatcacggta gctttcttct gcaccgtatc
    15721 cataatagct aaggtttgta aattgtgaac cgatagcaaa ttctagacca aattcaggga
    15781 agtttggcaa acctgcttta ccatcatagt ttgcagtaac aaagattcga cccttgtaat
    15841 caacttgata agttacctta acttcgacat cagacaagcc tggcaattca tgaacataag
    15901 tcactttaac agagtcgtct tcgatttgaa tttgagtatc tgtaacttta ctatagtttc
    15961 cagcaacctt ccagcctgcc atttcgaatg gatatccagc accacgatcg ttgtcagtgt
    16021 aagcacgagt gaagctaagt ttaggacctt tctcaatgaa ttcaacacca ttatacttag
    16081 cagatactaa agtattttgt gcacgtgaaa gcaagattga gaagttttgt ccttgaatac
    16141 cgatgttgaa gtcgccttca acaacattca aaggtgcttt aactggtgtt tcagtgctaa
    16201 tcttttcaac aacatattga ccacgaacaa tttcatgacc tttaggagcc cattcagttg
    16261 cttccctcag aacacaagca acttcgtaaa tttgttcaga atttgaagcc tcgactacaa
    16321 agttaactgg gaatgttgct tcttcgcctg gtttaacatc aaagtgatat tcactttcac
    16381 taacttttct accatcttcg taaactctag ctaggaaagt ataagcagaa agatcttcga
    16441 agagattatc attcttgata gttactgatt tttcatcaac agcaatctta atattagagt
    16501 aaagatgttt aactgtttga agttttggag ttagggtacg atctgcaaag acgataccat
    16561 ttccacaaaa ttcgtagtca gaaggtctat catgccagtc accaccatat gataggaatt
    16621 cgctaccatt tggaagtgtt ttgtaaatag cttggtcaat gaagtcccaa ataaatccac
    16681 cttggtattc tggatatttc tctaagtcag tgtagagttg caatccacca ccagagttac
    16741 ccattatgtg catgtattca catgaaatat aaggtttttg aggtttgtta gttaggttac
    16801 ctgaagcaaa gtgtttatca ctaacgcttg aaagatcaac tagtttacca gttgtgaggt
    16861 attcttcgat atcagctggt ttcgcataca tacgactttc gatgtctgta atgtaatcaa
    16921 actcacgaca ccatgcaaca ccttcatagt gaactggacg agtattgtca acactacgga
    16981 agtaatcagc catgtcagca atatctttac cagcatatga ttcattacca caagacc
//
