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### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaEDPMNEJH_1 (original name was: gnl|Prokka|EDPMNEJH_1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | cyclic-lactone-autoinducer | 658,078 | 678,946 |
Region 2 | lanthipeptide-class-ii,ranthipeptide | 882,564 | 919,690 | ruminococcin A | RiPP:Lanthipeptide | 14%
Region 3 | cyclic-lactone-autoinducer | 1,136,659 | 1,163,133 |
Region 4 | cyclic-lactone-autoinducer | 1,213,997 | 1,234,401 |
Region 5 | cyclic-lactone-autoinducer | 1,314,506 | 1,335,236 |
Region 6 | cyclic-lactone-autoinducer | 1,465,636 | 1,486,369 |
Region 7 | NRPS | 1,897,541 | 1,946,525 | dipeptide aldehydes | NRP | 82%
Region 8 | cyclic-lactone-autoinducer | 2,164,991 | 2,185,560 |
Region 9 | lanthipeptide-class-ii | 2,189,041 | 2,212,007 | xantholipin | Polyketide | 6%
Region 10 | ranthipeptide | 2,715,265 | 2,736,853 |
Region 11 | lanthipeptide-class-ii | 3,300,589 | 3,323,282 |

gnlProkkaEDPMNEJH_1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 658,078 - 678,946 nt. (total: 20,869 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 2 - lanthipeptide-class-ii,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 882,564 - 919,690 nt. (total: 37,127 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg1_785

ctg1_784
Leader:
MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS
Core:
Q F C T S T K E C N W G T I M F V C C
Core with dehydrations:
Q F Cys Dhb Dha Dhb K E Cys N W G Dhb I M F V Cys Cys

#### MIBiG 3.1 matches for ctg1_784

26.3% BGC0000503 (cinA): Lanthipeptide: cinnamycin
7
K E C N W G T I M F V C
18
+ C++G F V C
3
Q S C S F G P F T F V C
14
20.0% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide
2
F C T S T K E C
9
+C T T K E C
18
W C T L T K E C
25
17.9% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α
2
F C T S T K E C
9
+C T T E C
16
Y C T L T V E C
23
with 3 more sequence matches
13.6% BGC0000553 (SSGG_RS09925): Lanthipeptide: SRO15-2212
9
C N W G T I M F V C C
19
C + ++ V C
10
C E Y S S L S V V L C
20
12.8% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
3
C T S T K E C
9
C T +K E C
28
C T L S K E C
34
10.8% BGC0001229 (SBI_06989)and 1 other:
BGC0002110 (QKV49894.1) Lanthipeptide: birimositide
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
2
F C T S T K
7
F C +T K
27
F C P T T K
32

#### antiSMASH-DB 4.0 matches for ctg1_784

100.0% NZ_CP102267.1 and 11 others:
NZ_FMUW01000051.1 Lanthipeptides: BLP57_RS16830_lanthipeptide NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07130_lanthipeptide NZ_JAQEHQ010000024.1 Lanthipeptides: PGR68_RS13915_lanthipeptide NZ_JAQESL010000043.1 Lanthipeptides: PG840_RS15980_lanthipeptide NZ_JAQESS010000001.1 Lanthipeptides: PG808_RS00050_lanthipeptide NZ_LN913006.1 Lanthipeptides: BN3261_RS01470_lanthipeptide NZ_QRPQ01000011.1 Lanthipeptides: DWZ74_RS14610_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03120_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16305_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06255_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03580_lanthipeptide
Lanthipeptides: NQ550_RS04155_lanthipeptide
1
Q F C T S T K E C N W G T I M F V C C
19
Q F C T S T K E C N W G T I M F V C C
1
Q F C T S T K E C N W G T I M F V C C
19
42.9% NZ_QRHZ01000008.1 and 2 others:
NZ_QSRF01000021.1 Lanthipeptides: DXC87_RS15310_lanthipeptide NZ_QUEQ01000033.1 Lanthipeptides: DXA48_RS19000_lanthipeptide
Lanthipeptides: DW272_RS13830_lanthipeptide
2
F C T S T K E C N W G T I M F V C C
19
F C T S T E C N G T+ C C
11
F C T S T G E C N M G T L N I F C C
28
40.0% NZ_JAFCGV010000005.1: Lanthipeptides: JQI09_RS04275_lanthipeptide
4
T S T K E C N W G T I M F V C C
19
T+T E C G T F V C C
7
T A T S E C Y L G T F A F V C C
22
with 18 more sequence matches
40.0% NZ_WBPF01000002.1: Lanthipeptides: F8162_RS00195_lanthipeptide
1
Q F C T S T K E C N W G T--I M F V C C
19
Q F T + E C+W T +F C C
4
Q F D T I S H E C H W N T W Q F L F T C C
24
36.0% NZ_CP045267.1 and 1 other:
NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide
Lanthipeptides: FDZ14_RS00155_lanthipeptide
4
T S T K E C N W G T I M F V C C
19
T+T E C G T F C C
7
T A T S E C Y L G T F A F A C C
22
34.6% NZ_CP117876.1: Lanthipeptides: PQ460_RS01735_lanthipeptide
4
T S T K E C N W G T I M F V C C
19
T+T E C G T+ F+C C
7
T A T S E C Y L G T V A F I C C
22
33.3% NZ_CYXV01000003.1: Lanthipeptides: ARB75_RS04585_lanthipeptide
3
C T S T K E C N W G T I M F V C C
19
C T T E C N G T + C C
12
C T L T G E C N I G T H I K F C C
28
29.2% NC_012470.1 and 42 others:
NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptide NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptide NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptide NZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptide NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptide NZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide
Lanthipeptides: SZO_RS10260_lanthipeptide
4
T S T K E C N W G T I--M F V C C
19
T + E C W ++ +F C C
7
T I S A E C R W N S L Q A I F T C C
24
29.2% NZ_ALSD01000046.1 and 5 others:
NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide
Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide
4
T S T K E C N W G T I--M F V C C
19
T + E C W ++ +F C C
7
T I S A E C R W N S L Q A I F S C C
24
27.6% NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
Q F C T S T K E C
9
Q F C T T K E C
15
Q F C T L T K E C
23
26.3% NZ_CP059557.1: Lanthipeptides: H2Q94_RS19875_lanthipeptide
7
K E C N W G T I M F V C
18
+ C+W G + V C
3
Q S C S W G P V T A V C
14
25.0% NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
Q F C T S T K E C
9
Q+C T T K E C
15
Q W C T L T K E C
23
24.1% NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
Q F C T S T K E C
9
+F C T T K E C
15
R F C T L T K E C
23
21.6% NZ_CP016767.1: Lanthipeptides: BCV50_RS18735_lanthipeptide
1
Q F C T S T K E C N W G T I
14
Q+C T + E C +G T I
21
Q Y C T V S A E C-F G T I
33
20.6% NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
1
Q F C T S T K E C N W G T I M
15
+ C T T E C T I+
18
R L C T G T A E C P I M T I I
32
19.2% NZ_CZAY01000009.1 and 12 others:
NZ_CZBA01000009.1 Lanthipeptides: ARA06_RS08755_lanthipeptide NZ_CZBB01000003.1 Lanthipeptides: ARA29_RS04330_lanthipeptide NZ_JADPDU010000003.1 Lanthipeptides: I4V06_RS02990_lanthipeptide NZ_JAOQJU010000001.1 Lanthipeptides: OCV99_RS00835_lanthipeptide NZ_JAQCSY010000025.1 Lanthipeptides: PGZ10_RS13865_lanthipeptide NZ_JAQEDC010000020.1 Lanthipeptides: PHA23_RS12680_lanthipeptide NZ_QRZZ01000001.1 Lanthipeptides: DWV87_RS01465_lanthipeptide NZ_QSUB01000001.1 Lanthipeptides: DXB81_RS03120_lanthipeptide NZ_QUCI01000019.1 Lanthipeptides: DW648_RS14740_lanthipeptide NZ_QULD01000003.1 Lanthipeptides: DXB83_RS07060_lanthipeptide NZ_QULI01000007.1 Lanthipeptides: DXB71_RS08970_lanthipeptide NZ_SLZV01000043.1 Lanthipeptides: EDD74_RS14380_lanthipeptide
Lanthipeptides: ARA07_RS06830_lanthipeptide
2
F C T S T K E C N W G T I M F V C C
19
C T S T E C +G T++ C C
32
L C T S T A E C Y F G T L L K P C C
49
17.5% NZ_CM001792.1 and 1 other:
NZ_CM001792.1 Lanthipeptides: C794_RS17980_lanthipeptide
Lanthipeptides: C794_RS17980_lanthipeptide
2
F C T S T K E C
9
F C T T K E C
26
F C T I T K E C
33
17.1% NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptide
Lanthipeptides: BUE45_RS13060_lanthipeptide
1
Q F C T S T K E C N
10
+F C T T E C N
26
R F C T V T V E C N
35
16.7% NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide
Lanthipeptides: CN325_RS21845_lanthipeptide
1
Q F C T S T K E C
9
++C T++K E C
16
K Y C T A S K E C
24
15.8% NZ_BMRY01000003.1 and 28 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
1
Q F C T S T K E C
9
F C T+T E C
25
N F C T A T A E C
33
14.7% NZ_CAKMMP010000011.1 and 5 others:
NZ_CP018620.1 Lanthipeptides: BS614_RS05680_lanthipeptide NZ_CP062165.1 Lanthipeptides: JNUCC31_RS16755_lanthipeptide NZ_FMVM01000006.1 Lanthipeptides: BLQ13_RS10365_lanthipeptide NZ_RIAS01000010.1 Lanthipeptides: EC604_RS18225_lanthipeptide NZ_VEJI01000010.1 Lanthipeptides: FS576_RS22075_lanthipeptide
Lanthipeptides: L6H98_RS19925_lanthipeptide
2
F C T S T K E C N W G T I
14
F C T + E C++ ++
13
F C T V S H E C H Y N S V
25
allorf_0889319_0889417
Leader:
MIRSSIIFFVLNKLQGS
Core:
C Q V S V R F L S E K Y I I L
Core with dehydrations:
Cys Q V Dha V R F L Dha E K Y I I L

#### antiSMASH-DB 4.0 matches for allorf_0889319_0889417

100.0% NZ_CP102267.1 and 7 others:
NZ_JAQDBP010000004.1 Lanthipeptides: allorf_177044_177142_lanthipeptide NZ_JAQEHQ010000024.1 Lanthipeptides: allorf_20164_20253_lanthipeptide NZ_JAQESL010000043.1 Lanthipeptides: allorf_02084_02182_lanthipeptide NZ_JAQESS010000001.1 Lanthipeptides: allorf_017059_017148_lanthipeptide NZ_LN913006.1 Lanthipeptides: allorf_0097924_0098022_lanthipeptide NZ_QRPQ01000011.1 Lanthipeptides: allorf_103379_103477_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: allorf_092199_092297_lanthipeptide
Lanthipeptides: allorf_0889319_0889417_lanthipeptide
1
C Q V S V R F L S E K Y I I L
15
C Q V S V R F L S E K Y I I L
1
C Q V S V R F L S E K Y I I L
15
allorf_0904640_0904792
Leader:
MVISLHYIIGS
Core:
F T Y T V R T E Y V F I L G E V R C T Y C V S I G Y C Q R K V Y G Y K K S T D
Core with dehydrations:
F Dhb Y Dhb V R Dhb E Y V F I L G E V R Cys Dhb Y Cys V Dha I G Y Cys Q R K V Y G Y K K Dha Dhb D

#### MIBiG 3.1 matches for allorf_0904640_0904792

7.7% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide
20
Y C V S I G Y C Q R K
30
+C C Q
18
W C T L T K E C Q P N
28

#### antiSMASH-DB 4.0 matches for allorf_0904640_0904792

100.0% NZ_CP102267.1: Lanthipeptides: allorf_0904640_0904792_lanthipeptide
1
F T Y T V R T E Y V F I L G E V R C T Y C V S I G Y C Q R K V Y G Y K K S T D
39
F T Y T V R T E Y V F I L G E V R C T Y C V S I G Y C Q R K V Y G Y K K S T D
1
F T Y T V R T E Y V F I L G E V R C T Y C V S I G Y C Q R K V Y G Y K K S T D
39
20.5% NZ_CP011129.1: Lanthipeptides: allorf_3545239_3545370_lanthipeptide
4
T V R T E Y V F I L G E V R C T Y C V S I G
25
T+ T + F R C C S G
5
T L A T A H A F D Q S R R R C K T C E S R G
26
15.4% NZ_CP013140.1: Lanthipeptides: allorf_2670844_2670996_lanthipeptide
18
C T Y C V S I G Y C Q
28
C T C V G C+
10
C T P C V R A G A C R
20
with 1 more sequence matches
12.8% NZ_CP036019.1 and 1 other:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27195_lanthipeptide
Lanthipeptides: EXW52_RS27195_lanthipeptide
21
C V S I G Y C Q R K V Y
32
+S+G C K+Y
17
A I S V G L C P T K M Y
28
allorf_0904958_0905074
Leader:
MKLISHVLPMSKEIKKSAKKTINMVVNAM
Core:
T W Y K E C T N T
Core with dehydrations:
Dhb W Y K E Cys Dhb N Dhb

#### antiSMASH-DB 4.0 matches for allorf_0904958_0905074

100.0% NZ_CP102267.1: Lanthipeptides: allorf_0904958_0905074_lanthipeptide
1
T W Y K E C T N T
9
T W Y K E C T N T
1
T W Y K E C T N T
9

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_784 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 2127.9 Da
  Molecular weight: 2129.5 Da
  Number of bridges: 4
allorf_0889319_0889417 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 1761.0 Da
  Molecular weight: 1762.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1780.1 Da N = 1
allorf_0904640_0904792 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 4512.3 Da
  Molecular weight: 4515.2 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4533.2 Da N = 1
    4551.2 Da N = 2
    4569.2 Da N = 3
    4587.2 Da N = 4
allorf_0904958_0905074 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 1090.5 Da
  Molecular weight: 1091.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1109.2 Da N = 1
    1127.2 Da N = 2

gnlProkkaEDPMNEJH_1 - Region 3 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,136,659 - 1,163,133 nt. (total: 26,475 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,213,997 - 1,234,401 nt. (total: 20,405 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 5 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,314,506 - 1,335,236 nt. (total: 20,731 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 6 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,465,636 - 1,486,369 nt. (total: 20,734 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,897,541 - 1,946,525 nt. (total: 48,985 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 1897540 - 1946525:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1713: X - X - X
  AMP-binding (20..419): X
  nrpys: Leu, Trp
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVLTDGGISK
    Nearest Stachelhaus code(s):
      Leu or Trp DVLTDGGISK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1033..1421): X
  nrpys: Leu, Trp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAMFSGAIFK
    Nearest Stachelhaus code(s):
      Leu or Trp DAMFSGAIFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2027..2418): X
  nrpys: Leu, Trp
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAITTGGVSK
    Nearest Stachelhaus code(s):
      Leu or Trp DAITTGGVSK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaEDPMNEJH_1 - Region 8 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,164,991 - 2,185,560 nt. (total: 20,570 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 9 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,189,041 - 2,212,007 nt. (total: 22,967 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg1_1965

ctg1_1962
Leader:
MKTCSERNEQRINSLQLSESLEDEIKELDGKNVEAGDVIFT
Core:
T D T S S F L T I V C C
Core with dehydrations:
Dhb D Dhb Dha Dha F L Dhb I V Cys Cys

#### antiSMASH-DB 4.0 matches for ctg1_1962

100.0% NZ_CP102267.1 and 2 others:
NZ_JADMOE010000006.1 Lanthipeptides: I2G55_RS05425_lanthipeptide NZ_LT635469.1 Lanthipeptides: BQ7352_RS14540_lanthipeptide
Lanthipeptides: NQ550_RS10225_lanthipeptide
1
T D T S S F L T I V C C
12
T D T S S F L T I V C C
1
T D T S S F L T I V C C
12
50.0% NZ_CP113781.1: Lanthipeptides: GGADHKLB_RS14125_lanthipeptide
2
D T S S F L T I V C C
12
+ + F L T I+C C
2
N C T H F L T I L C C
12
40.0% NZ_AP025566.1: Lanthipeptides: MWL92_RS00840_lanthipeptide
4
S S F L T I V C C
12
+S F T I+C C
7
T S F C T I I C C
15
with 10 more sequence matches
33.3% NZ_CP036524.1: Lanthipeptides: LAJLEIBI_RS18025_lanthipeptide
4
S S F L T I V C C
12
++F T I+C C
7
T T F F T I I C C
15
31.6% NZ_CP036170.1: Lanthipeptides: HDCHBGLK_RS18795_lanthipeptide
4
S S F L T I V C C
12
+F L T I C C
11
G T F L T I Y C C
19
29.2% NZ_CP048626.1: Lanthipeptides: GXM18_RS04600_lanthipeptide
2
D T S S F L T I V C C
12
D +S F T I C C
14
D N A S F F T I F C C
24
26.9% NZ_CP070036.1 and 3 others:
NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16805_lanthipeptide NZ_JADNGF010000061.1 Lanthipeptides: I2E06_RS15650_lanthipeptide NZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16660_lanthipeptide
Lanthipeptides: I6K72_RS03970_lanthipeptide
4
S S F L T I V C C
12
S+F L T I C C
18
S A F L T I Y C C
26
20.6% NZ_JADPCB010000035.1: Lanthipeptides: I4W51_RS14990_lanthipeptide
3
T S S F L T I V C C
12
T +F L T I+C C
25
T G A F L T I L C C
34
17.9% NZ_CP094681.1: Lanthipeptides: K5I26_RS05295_lanthipeptide
1
T D T S S F L T I V C C
12
+D + F L T I C C
28
S D C A L F L T I F C C
39
17.9% NZ_JAOQJV010000004.1: Lanthipeptides: OCV65_RS05205_lanthipeptide
4
S S F L T I V C C
12
S F L T I+C C
31
S G F L T I I C C
39
17.6% NZ_MCGI01000004.1 and 1 other:
NZ_MPDJ01000004.1 Lanthipeptides: BLA28_RS33805_lanthipeptide
Lanthipeptides: BEH84_RS33640_lanthipeptide
1
T D T S S F L T I V C C
12
T+++ F L+I C C
23
T E S T P F L S I F C C
34
15.8% NZ_LT969517.1 and 1 other:
NZ_QVLV01000012.1 Lanthipeptides: DXC51_RS29565_lanthipeptide
Lanthipeptides: C1733_RS32195_lanthipeptide
1
T D T S S F L T I V C C
12
T ++ F L+I C C
27
T A S T G F L S I F C C
38
15.4% NZ_JADNBM010000025.1 and 2 others:
NZ_JAQDZW010000013.1 Lanthipeptides: PGT55_RS13345_lanthipeptide NZ_QVMC01000003.1 Lanthipeptides: DWV46_RS15805_lanthipeptide
Lanthipeptides: I2A62_RS14145_lanthipeptide
4
S S F L T I V C C
12
++F L T I C C
31
T A F L T I F C C
39

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_1962 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 1198.6 Da
  Molecular weight: 1199.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1217.4 Da N = 1
    1235.4 Da N = 2
    1253.4 Da N = 3

gnlProkkaEDPMNEJH_1 - Region 10 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,715,265 - 2,736,853 nt. (total: 21,589 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaEDPMNEJH_1 - Region 11 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,300,589 - 3,323,282 nt. (total: 22,694 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg1_2988

ctg1_2989
Leader:
MNEMNDKIIGNVEKELDEIEIIDTESIEEKLSFIVYG
Core:
T I V C C
Core with dehydrations:
Dhb I V Cys Cys

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg1_2989 - Class II
  Cleavage pHMM score: -5.90
  RODEO score: 0
  Monoisotopic mass: 519.2 Da
  Molecular weight: 519.7 Da
  Number of bridges: 1