LOCUS       gnlProkkaHHEELPKI_68   13517 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HHEELPKI_68.
ACCESSION   gnlProkkaHHEELPKI_68
VERSION     gnlProkkaHHEELPKI_68
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 14:22:17
            Original ID  :: gnl|Prokka|HHEELPKI_68
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13517
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13517
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[6878:9875]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6879..9875
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13517
                     /SMILES="NC(C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13517
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(230..1084)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_1"
                     /sec_met_domain="TIGR01716 (E-value: 2.7e-61, bitscore:
                     196.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKLGSTLRKVRNGKQISICSVADEHLSKSQISRFERGESEISC
                     IRLINILDKLHITLDEFLILHDEDYTKTESFANLVQYIRKQYSLQNINNIQSLLSDSSN
                     YTLDPFEKTMVKSILHTMDSSIIPSDDELLQLADYLFKVEKWGYYEIILLGNCVRTIDY
                     NSVFLLTKEMLNNYIYSSLNKTNKRIVTQLAINCLILSIDMEEFTNCFYLIDEIKALLD
                     NELNFYEQTVFLYATGYFEFKRWQSTSGIEKMKQAIQVLDILGEDNLKLHYTIHFDKLI
                     NNK"
     CDS             1338..2246
                     /locus_tag="ctg42_2"
                     /transl_table=11
                     /translation="MKLFEDLQWRGLVKQYSSDSLIEKLNNGKLTFYIGTDPTADSLHL
                     GHYSSFLIAKRLAKYGHQPIILIGGATALVGDPRGTSERDLAEQEKIFDNFEKLKNQIQ
                     KIFPYEIVNNYDWTKNIMAIDFLREFGKHITAGYMSNKELVKRQFATGISFTEFSYMLL
                     QGMDFYHLFTTKGVTLQIAGSDQWGNMTTGIDLVRKKTGEEVFAMTMPLITDEEGKKFG
                     KSEGNAIWISENKNTPEELHNFLLNVSDDIVISLLKKLTFLSRKDIEEIESRHKNGTGY
                     AQGILADTVTFDIHGVSINKK"
     CDS             3040..3648
                     /locus_tag="ctg42_3"
                     /transl_table=11
                     /translation="MEYTSAGVILINMNSKVLIVQYPEGHWGFPKGYKETEDKSLVDTA
                     KRELKEEIDISPNFFLDTNRYQFNESYGKKKIIYFIAFTINSNINLCNGLNSYKWVDIE
                     DLDKFPGFLSKQIVRKLVELKLDDITIVKKVNLKDNITKTNEKVDIPPSKHAYSRLVPL
                     ELINDNIKIENIPNTIDSYYLNNLLNRVNKHCSNECFFY"
     CDS             3629..4696
                     /locus_tag="ctg42_4"
                     /transl_table=11
                     /translation="MSVFFIDDDEISNCWSMVNILPAVVWKVGKVYLPGKPSGCSIGKR
                     PMNLYLKIMKDFGFEITENNGGFYLEKGNAGISEITLPFPSFTGTSIAIYLAMLSNNEI
                     NINNVSIEPEIIYLISVIKNLGYKIIFDKIARVIKFKGKTENNGVLSVRVPFDRNVLVT
                     RMVSDLVSYGKFEWLNEEQHYLEELLLFLKKCGFEIYSDDYRIKIVALDKVVDQERVVL
                     NCGHFPKICSDWQPLLVILLCHYLIPFELSDDVFENRFQIFSQLVYLNNNIVLNKKSSN
                     KIVIDYCDTTEKITTSSNLEFKLLNIRDAAAILIASHQSKLNIEFSNLLQLFRGYETLE
                     NVLGEKVELYSYEKQ"
     CDS             4683..6293
                     /locus_tag="ctg42_5"
                     /transl_table=11
                     /translation="MKNNDIIEFIRTKISREFNLEDELDGISIHIVGSLAIKIRLGRSL
                     ENYFNGESDIDCIVVVLENGIITQNSKIFERKVLDTFLNNQVDVINYSIVYGKKRNSIN
                     IKFIKKENLYKLTDIREVNFKSMRKDSLVRHKPVTKFYGEESEIEFEFEYLEKQAGELY
                     MIEYHFFTFSNNIFFLCDIHSMLLFSLNISNKNYKDLPEIFFFKMELYSILKKKDDLYY
                     FSMFKNFHHIVKSPKELSKLVPKLSIFLIDKDESIDLLTYFEIRKLTRDASLDPIIINC
                     GVREPHDFIRTDFLNFKIYTALEILENFSWIKTIQDPKIYLEANENDNLYSVIELFSLF
                     EEFSNKLNNIFASKKICSDKNMSRFEDYYDKKLFFQMDSKVSSNLNFLGGLEDCFYKLV
                     KLNDTELIKMSDEFFSEKTKKIENIIQKYNIIVKLVSFLCNEDASNTSKSLKNFFEELT
                     NTKAKMLKNIKKIPPSSDTASLIDVLFLSGDFKSKNELHRLFKQNSVKSLSGEILKQGC
                     IDFKGEVIKIGKRRYYKIE"
     CDS             6286..6834
                     /locus_tag="ctg42_6"
                     /transl_table=11
                     /translation="MSKNFSKENNVGVLIWARSTPKENIFQEMISLVEQNYKKNIIFFV
                     DDLCPQQVYNRSKETQNFYNEKYRSYFKSKNVQFYFSSQLVSLEKIDNHYLQEMIDDMT
                     IKEYVTILPHKKHENGEFELNEVIHTIFQELLLKEALSMVSTILLGKFSQNLVIFHKKI
                     TGQNIETIIIERMSYNRRK"
     CDS             6879..9875
                     /NRPS_PKS="Domain: AMP-binding (9-397). E-value: 1.8e-65.
                     Score: 213.0. Matches aSDomain:
                     nrpspksdomains_ctg42_7_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (498-564). E-value: 6.7e-17.
                     Score: 53.7. Matches aSDomain:
                     nrpspksdomains_ctg42_7_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     185.1; E-value: 3e-56)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_7"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-70, bitscore:
                     227.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-17, bitscore:
                     53.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPISNVILKLEESASHYPKKTAIYGINKNFTYEEVQRITSFFSNY
                     LGKIVGKNKNIGLILEHNENIIISFFSILKSNNTYVPFSTKTNFNRIKDSIDDLNINYL
                     ITDNYNFSTIQEEFKGNYIINIDDYLDISQIPSNYKKEIEDSETQDIVYIMHTSGSTGK
                     PKGVKVTVNNLNYITENVQRITPCDEDSTLLFMTPYTFDVSITEICGWVYNGGAVVCRD
                     LNSNTWFDDIREVLYKYNITHVAACPSVFLTMMNIYSNEINIFNNLKFVVLAGERFSLN
                     IHKVWKESNWSFRLFNAYGPTETTVYCTLYELSKESSYDEIPIGTPLQGVEYIIDENTS
                     ELLVSGQCITNGYLDYENTSKYFINVNDCLYYKTGDLVELNGGLLYFKGRNDKQIQLNG
                     MRVELGEIENRIEEIEYVDQSKVIYKNNKIIAFIKTKYFDEEYFKNYFSQNFEKHLIPN
                     NFHLVSEFPLNQSKKVDKDRLMYNFLDTEESDSMLNELELEIKDLFENVITIGKEKITK
                     NSNFFNLGGDSLSSVLLLMGLEERFNISITLSDIYNYPTIMQLSKYIDSLKKNKNIDDE
                     PKKNENIKIDINTMTAELKNVENYIYRSGQIVSKYETLHLQRVYYYDNFESFIEFEYVF
                     QKGEAFEVVVGLINDLIANVTMLRTSFVFEDDKLYFVEKAMENLDSMPIFDVSYQSIDY
                     ISDIKKNIRMILMDSRKEGGLLNSLILLKNDKQYTLIGLMDHSIADASTPATILEIISN
                     LKNGKKINFESTYEDYIKLIHKNNNMYEIMKSSFYQDLVKCGEDSEFEIKKMESSLNVY
                     KVDLESDAKSLSTQQINLFLAYNIGQYLLKLFNQHSIVIKCLANGKDYLGTKYKYTLGD
                     FHTSIYIVVYKDENYLDYKKRVEDSIKTNYVEKVFRPTYVYGSNYPIKNNDQKLLKNSL
                     RHTTNTSIDFLGIIKEDDLERYTKSVKQSLYQLTQIDDTLYVTVYLVNNQLVIYTNKDF
                     LDFETFVKL"
     aSDomain        6906..8069
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg42_7_AMP-binding.1"
                     /evalue="1.80E-65"
                     /label="ctg42_7_AMP-binding.1"
                     /locus_tag="ctg42_7"
                     /protein_end="397"
                     /protein_start="9"
                     /score="213.0"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="LEESASHYPKKTAIYGINKNFTYEEVQRITSFFSNYLGKIVGKNK
                     NIGLILEHNENIIISFFSILKSNNTYVPFSTKTNFNRIKDSIDDLNINYLITDNYNFST
                     IQEEFKGNYIINIDDYLDISQIPSNYKKEIEDSETQDIVYIMHTSGSTGKPKGVKVTVN
                     NLNYITENVQRITPCDEDSTLLFMTPYTFDVSITEICGWVYNGGAVVCRDLNSNTWFDD
                     IREVLYKYNITHVAACPSVFLTMMNIYSNEINIFNNLKFVVLAGERFSLNIHKVWKESN
                     WSFRLFNAYGPTETTVYCTLYELSKESSYDEIPIGTPLQGVEYIIDENTSELLVSGQCI
                     TNGYLDYENTSKYFINVNDCLYYKTGDLVELNGGLLYFKGRNDKQIQL"
     aSModule        6906..8570
                     /complete
                     /domains="nrpspksdomains_ctg42_7_AMP-binding.1"
                     /domains="nrpspksdomains_ctg42_7_PP-binding.1"
                     /locus_tags="ctg42_7"
                     /monomer_pairings="Ala -> Ala"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       7335..7388
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg42_7_0001"
                     /evalue="6.00E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg42_7"
                     /protein_end="170"
                     /protein_start="152"
                     /score="21.9"
                     /tool="antismash"
                     /translation="YIMHTSGSTGKPKGVKVT"
     CDS_motif       8037..8102
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg42_7_0002"
                     /evalue="3.90E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg42_7"
                     /protein_end="408"
                     /protein_start="386"
                     /score="25.6"
                     /tool="antismash"
                     /translation="FKGRNDKQIQLNGMRVELGEIE"
     aSDomain        8373..8570
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg42_7_PP-binding.1"
                     /evalue="6.70E-17"
                     /label="ctg42_7_PP-binding.1"
                     /locus_tag="ctg42_7"
                     /protein_end="564"
                     /protein_start="498"
                     /score="53.7"
                     /tool="antismash"
                     /translation="EIKDLFENVITIGKEKITKNSNFFNLGGDSLSSVLLLMGLEERFN
                     ISITLSDIYNYPTIMQLSKYI"
     CDS             10059..11288
                     /locus_tag="ctg42_8"
                     /transl_table=11
                     /translation="MKILLNKYTPTLAKLNYLADQDAIVIAPLDTQKKYEKYLMKGNRL
                     PKIIYLEDYTLPKMISIIRESIDVDSIEEVLTLDEHYMWHAGFLNDYFKKKNSSYLVNS
                     LFQDKYLMRSVLFEIVPQPMFRLIETQKDIELFWKNTAGDKSIIKPRFGAACVGIKKYS
                     RGEQIPEKFINSQYIIEEYVDLQKMLTCDGYSQGSNIIRFYSHEYEELLLGTIGTSDEF
                     TVRTNSLYEKNIPFLRKIFSECSKVLKEFVNDYSIIPFHFEWFFDENKGEFVFCEVGKR
                     FGGGDIPNLIQRSFGVNIFEEFWGNVFDNKELHPSTDLERPKFISATYCPYKKRGKLVS
                     APDMELFEWTDEIYVFSKVGEESDGITSVVEGDFIAIIVSETEEQHNQKLSKLRELSEQ
                     FIWEERFERR"
     CDS             11275..11538
                     /locus_tag="ctg42_9"
                     /transl_table=11
                     /translation="MKDVKKKNILYLVSSKGVSRIGDTMFDFANNTFLAGINPTSLSLV
                     AVYQSLESVIGVLFNLFGGVFADSFKRKKLLLLQISCVVLLA"
     CDS             11517..12485
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 198.4; E-value: 3e-60)"
                     /gene_kind="transport"
                     /locus_tag="ctg42_10"
                     /transl_table=11
                     /translation="MCGIACLVLSFISQDQWLVYAIVLTNVILAFMSTFSGPSYKAFTK
                     EIVKKDSISQLNSLLETTSTVIKVTIPMVAIFLYKLLGIHGVLLLDGLSFLIAALLIFF
                     IVPINEAVVTKEKMTFRGIINDLKIGFKYVYNHKSIFIIIVLSALVNFFLAAYNLLLPY
                     SNQMFGEISTGLYGTFLTAEAIGGFIGAILSSFVNKKLSSKKLMLFLSLSGLVLMLATP
                     FYIMFHNVIILAISPALFSLFLSIFNIQFFSIVQRDVDNEFLGRVFGIIFTVAILFMPI
                     GTGFFSVVLNPNNTFNLFIIGASITVLSLVFGILFKRYNMS"
     CDS             complement(12691..13515)
                     /gene_functions="other (smcogs) SMCOG1206:transposase
                     (Score: 269.5; E-value: 8.1e-82)"
                     /gene_kind="other"
                     /locus_tag="ctg42_11"
                     /transl_table=11
                     /translation="MHYDKLPAVMSWDEFGFKKGELAFVAQNYETNQLITILDNRRQTT
                     IRNYFLKYPLKVRQQVQFITMDMSGAYIPLARKLFPNAKIVLDRFHIIQHLGRAFLKTR
                     IAIMNQFDKKSLPYRALKNHWRLFQKDSCKLSLNSFYSKTFRQTLAPHEVVKKTLVFSK
                     ELTDYYTLYQILLFHFQEKRVGEFFDLIEENRSKVNHYFQTVFRTFLRHKQYIQNALET
                     DYSNAKLEATNKLIKDIKRLGFGFRNFINFKKRVFITLNIHKKRTYPVLSRC"
ORIGIN
        1 cgtgttttca tcactctgaa catacaaaaa gagaagacct atcaggtcct ctctagatgt
       61 tagcttttcg tcacccacta cagttgacaa agaaccatag taaaaagcct tgactaccaa
      121 gactttttac tatggcttca agctagtttc taagcaggtt caaattttcc atttatagct
      181 taagtgatca ggccagaaaa ggaggaaaat taaatagtag ataattactt tatttgttgt
      241 ttatcagttt atcaaaatga atagtatagt gtaattttaa attatcctct cctaaaatat
      301 caagtacttg tatagcctgt ttcatttttt caattccact agttgattgc caacgtttaa
      361 attcaaagta accagttgca tagagaaaaa ctgtctgttc ataaaagttt aattcgttat
      421 ctaacaatgc ttttatctca tcgattaaat agaagcaatt agtaaattct tccatatcta
      481 tgctaaggat taaacaattg atagcaagct gagtgacaat tcgcttatta gttttattca
      541 atgaagagta gatataattg tttaacattt ctttcgttaa tagaaagacg gagttgtagt
      601 caatggttcg tacacagtta cctaataaaa tgatctcata gtatccccat ttttcaactt
      661 taaagagata atctgctagt tgaagtaatt catcatctga tggaatgatg cttgaatcca
      721 ttgtgtgtaa aatggatttt accattgttt tttcaaaagg atctaaagtg taatttgagg
      781 aatccgaaag tagagattgt atattattga tgttttgtaa tgaatattgt ttacggatat
      841 actgtactaa gttggcaaat gactcagttt ttgtatagtc ttcatcgtgt aaaataagaa
      901 actcatccaa agtaatgtgt aatttgtcta gaatattgat cagtcggata catgatatct
      961 ctgactctcc acgttcaaat cgggatattt gcgattttga aagatgctca tcagcaacag
     1021 agcatatact tatttgtttg ccgttacgaa cttttctaag tgtgctacca agttttgatt
     1081 tcataatttt cccatttccc caacaaaaaa gttaacttag ttttaattat tgtacaataa
     1141 atagaaattg aaaggaagtc taaatatgga gaaagtttca aaaattttgc cgattttgat
     1201 tttagtgatg gatattatca ttattgttgg tgggtaattt acttaggtgt acacctaagt
     1261 ctttagaaga ctctaaagac ttaatattat aactgtttga ttatagtaca gattttttaa
     1321 gaaagaggta taaacaaatg aaattatttg aagacttaca atggagaggg cttgttaaac
     1381 aatattctag tgatagtcta attgaaaagc taaataatgg aaaattaact ttttacatag
     1441 gaacagatcc aactgcagac agcttacatt tagggcacta ttcatcgttc ttaattgcaa
     1501 aacgactagc taaatatgga catcaaccta tcattttaat tgggggggct actgcattgg
     1561 taggggatcc gcgcggaacc tcagaaagag atttagcaga gcaagagaaa atatttgata
     1621 attttgaaaa attaaaaaat caaattcaaa aaatattccc atacgagatt gtgaataact
     1681 atgattggac aaaaaatata atggcgattg atttcttaag ggaattcggt aaacacataa
     1741 cggcaggtta tatgtctaat aaagaactag taaagagaca atttgcgaca ggaatatcat
     1801 ttactgaatt ttcatatatg cttttacaag gaatggattt ttaccatctt tttactacta
     1861 agggagtgac acttcaaata gctggatcag atcaatgggg aaatatgaca actggaattg
     1921 atttggtaag aaaaaaaact ggagaagaag tgtttgctat gactatgcca ctaataacag
     1981 atgaagaggg gaaaaaattt ggaaagtctg aaggaaatgc tatttggatt tctgaaaata
     2041 agaatacgcc agaagaactt cataattttc tactaaatgt ttcagacgat attgttattt
     2101 ctttattaaa aaaattaact tttttgtcta gaaaagacat tgaagaaatt gagagtagac
     2161 ataaaaacgg aactggctat gcacagggca ttttagcaga tactgtaaca tttgacattc
     2221 atggagtaag tataaataaa aaataaactc ttagatggag gtagataaac tgtaataaaa
     2281 attcatagtt tcttgctcca agtcatattc ttggatgcac gacaaatgat catgaaatgt
     2341 ggccgatttt aaagataaca ttctatcggt cacatgagtt agatcatctg tttattttca
     2401 aaaatttagt aaatttgata ggtttattga actaagtaaa tcaattatgc agattacctt
     2461 gtgtgttatt ctttccaact cgcttacttc tttttaagag atatgtctgt taagaaattt
     2521 taactatcct gtttattaac ataattgtat tgttcacatt ttttggggtg agaagagttt
     2581 tttatgtgat actaacaatt gatgttgttg gtttagtata aagcttatag tcctggctac
     2641 gagagaaatg aaggagaaaa agttacgatg tccagagtca gagtctttta gagtgataag
     2701 aacttcttga ttgagatatt ttagactgct gtgtaagaat tcaagcatat attagtttaa
     2761 aaaatctaag cgagtgtgac cgactttttc tagttcgtat agtgttcaat cgaacttgct
     2821 actctatgca atttttgttg aatcatctaa cgtgagatga aacataagta tgttaccaaa
     2881 tagataatca attgcgataa aaattgtgat aagggaatcc cccaaaaaat acatgatttg
     2941 aataaaataa cctatctaca gtcgcttatt ctaagttaat cgcttaggct ttggcagtag
     3001 ctaactgcac taaatactag tataaggata agttaacata tggagtatac atctgctgga
     3061 gtaattttaa ttaatatgaa ttcaaaagta ctgatagtac agtatccaga gggacattgg
     3121 gggtttccaa aggggtataa agagaccgaa gataagtcac ttgtcgatac agcaaaaaga
     3181 gaattgaaag aagaaattga catatcacca aatttctttt tggatactaa taggtatcaa
     3241 tttaatgaaa gttatgggaa aaagaaaatt atatatttta tagcttttac tattaatagt
     3301 aatattaatc tatgtaacgg cttaaactca tataaatggg ttgatattga agatttggat
     3361 aaatttcctg gctttttatc taaacaaata gtcagaaaat tggtagaact aaaattggat
     3421 gatattacta ttgttaagaa agtaaatttg aaagataata ttactaaaac taatgaaaaa
     3481 gtggatatac caccgtcaaa acatgcttac tctaggttag tccctttaga attgattaat
     3541 gataatatca aaatagaaaa cattcctaat acaatagatt catattattt gaataattta
     3601 ctaaatagag tgaacaagca ttgttcaaat gagtgttttt tttattgatg atgatgagat
     3661 ttcgaattgc tggtcaatgg ttaatatctt accagctgta gtttggaagg taggaaaagt
     3721 ttatttaccc ggaaaaccta gtggttgcag tattgggaaa cggccaatga atctttattt
     3781 gaaaattatg aaagattttg ggtttgaaat tactgaaaat aatggaggat tttatttgga
     3841 aaaaggtaat gcaggaataa gtgaaattac tttaccattt ccttcattta caggaacatc
     3901 tatagcaatt tacttggcaa tgttatcaaa taatgaaata aatattaaca atgtttcaat
     3961 tgaaccagag ataatatatt taatttctgt tataaaaaat cttggctaca aaattatatt
     4021 tgataaaatt gcaagagtta tcaaatttaa aggaaagact gaaaataatg gagttttatc
     4081 tgtcagagtg ccatttgata gaaatgtttt agttactaga atggtatcag atctagtaag
     4141 ttatggaaaa tttgaatggc ttaacgagga gcaacactat ttggaggaat tgttactatt
     4201 tttgaaaaaa tgtggctttg aaatttattc agatgattat cggataaaaa ttgtagcact
     4261 agataaagta gtagaccaag agcgtgtggt tttaaattgt ggccatttcc ctaaaatttg
     4321 ctcagattgg caaccattac ttgttatttt attatgtcat tatttgattc cgttcgaact
     4381 ttcagatgat gtttttgaaa atagatttca aattttttca caactagtgt atttaaataa
     4441 taatattgtt ttaaataaga aatcttcaaa taagattgta attgattatt gcgataccac
     4501 agaaaaaatt acaaccagct ctaatttaga gtttaaatta ttaaatatca gagatgctgc
     4561 cgcaatttta atcgcaagtc atcaaagtaa attaaatata gaatttagta atttgttgca
     4621 gctttttaga ggttatgaga ctcttgagaa tgtattaggt gaaaaagtag aattatatag
     4681 ctatgaaaaa caatgatatt atagaattta taagaacaaa aatttctaga gaattcaatt
     4741 tggaagatga actagatggt ataagtattc acattgtcgg atcattagca attaaaataa
     4801 gattagggcg gagtctagaa aattacttta atggtgaaag tgatatagac tgtattgtgg
     4861 tagttcttga aaatggaata ataacacaaa atagcaaaat ttttgaaaga aaagtgctag
     4921 acactttctt aaataatcaa gtagatgtga ttaactattc tattgtatat ggtaaaaaaa
     4981 gaaacagtat caatatcaaa tttatcaaaa aagaaaattt atacaagctt actgacatta
     5041 gagaagtaaa ctttaaaagt atgagaaaag attctttagt aagacataaa ccagttacca
     5101 aattttatgg agaagaaagt gagattgagt ttgagtttga gtatttagaa aagcaggctg
     5161 gagaattata tatgattgaa tatcattttt ttacattttc aaataatatt ttcttcttgt
     5221 gtgatataca ctcaatgtta ttatttagct taaatataag taataaaaat tataaagatc
     5281 ttccggaaat attcttcttt aagatggaat tatattccat cttaaagaaa aaagatgatc
     5341 tatattattt ttcgatgttt aaaaattttc atcatatagt aaaatctcct aaagagcttt
     5401 caaagttggt tccgaagtta agtatttttt taattgataa agatgaatca atagatttac
     5461 tcacatattt cgaaattaga aaattaacta gagatgcatc tctagacccc atcattatta
     5521 attgcggagt aagagagcca cacgatttta taagaactga ttttttaaat tttaagattt
     5581 atactgctct cgaaatttta gagaattttt catggataaa aaccatacaa gatccaaaaa
     5641 tctatttaga agctaatgaa aatgataatc tgtactctgt aattgaatta tttagtttat
     5701 ttgaagaatt ttcgaataaa ctaaataata tttttgcatc aaaaaaaatt tgtagcgata
     5761 aaaatatgag tagattcgaa gattattatg ataagaaatt attttttcaa atggatagca
     5821 aagtatcttc taatttaaac tttttaggcg gtttggaaga ttgcttctac aaattggtca
     5881 aacttaacga tacagaatta attaaaatga gtgatgagtt tttttctgaa aaaactaaaa
     5941 aaattgagaa tattattcaa aaatataata ttattgtgaa gttagtatca tttttatgta
     6001 atgaagatgc ttccaatacc tcaaaaagtt taaagaattt ttttgaagaa ttaacgaata
     6061 caaaagcaaa aatgttaaaa aacataaaaa aaataccccc ctctagtgat actgctagct
     6121 taattgatgt actgttttta tctggtgatt ttaagtcaaa aaatgaactt catcggcttt
     6181 ttaagcaaaa ctcagtaaag tcattatctg gtgaaatact aaaacaaggt tgtatagatt
     6241 ttaaaggaga agtaattaaa ataggtaaaa ggagatacta taaaattgag taaaaacttt
     6301 agtaaggaaa acaatgtagg tgttttaata tgggctagaa gtactcccaa ggagaatatt
     6361 tttcaagaaa tgataagtct tgttgagcaa aattataaga aaaatattat attctttgtt
     6421 gacgatttat gtcctcagca agtctacaat agaagtaagg aaactcaaaa tttttataat
     6481 gaaaaatata gaagttattt caagtcaaag aatgtgcaat tttattttag tagtcagtta
     6541 gttagtttag aaaaaattga taatcactat ttacaagaaa tgattgatga tatgacaata
     6601 aaagaatatg tcacaattct tccgcataaa aagcatgaaa atggtgaatt tgagctaaat
     6661 gaagttatcc atacaatttt tcaagaatta ttacttaagg aagcactttc tatggtctca
     6721 acgattttgt taggaaagtt tagtcagaat ctagtgattt tccataaaaa aatcacgggg
     6781 caaaatattg aaactattat cattgaaaga atgagttata atagaagaaa gtaaattatt
     6841 tgaaatttat taatttaaag tgcattgagg agaaaactat gcctatcagt aatgtaattt
     6901 taaagttaga ggagagtgcg tcgcactatc ctaaaaaaac tgccatttat ggaataaata
     6961 aaaactttac atacgaggaa gtacaacgta tcacaagttt tttttctaat tatctaggaa
     7021 aaatagttgg aaaaaataaa aatataggat taattttgga acataatgaa aatattatta
     7081 tttcattttt ttcaatacta aagtccaaca atacctatgt tccgtttagt acaaagacta
     7141 attttaatag aattaaagat agtattgacg atttgaatat aaattatctg attacagata
     7201 attacaattt ttctactata caagaagaat ttaaagggaa ttacattatt aatatagatg
     7261 attatcttga tattagccaa atcccttcca attataaaaa agaaatagaa gatagtgaaa
     7321 ctcaggatat tgtttatata atgcatacct cagggagtac tggaaaacct aagggggtta
     7381 aggtaacggt aaataacttg aattacatta cagaaaatgt tcaaagaata actccttgtg
     7441 atgaagattc gactctacta tttatgactc cgtatacttt tgatgtttca attactgaaa
     7501 tatgtgggtg ggtttataat ggtggcgcag tagtttgtag ggatttaaat tcaaatactt
     7561 ggtttgatga tataagagaa gtactataca aatataatat tacgcatgtt gccgcatgcc
     7621 cttctgtatt tttaactatg atgaatatat actcaaatga aataaatata tttaacaatt
     7681 tgaaatttgt ggtacttgcg ggtgaacgat ttagtttaaa tatccataag gtttggaaag
     7741 aaagtaattg gtcgtttcga ttattcaatg cgtatggtcc cactgagaca accgtttatt
     7801 gtactttata tgaattatca aaagaaagca gctatgatga aattccaatt gggacacctt
     7861 tgcaaggtgt tgaatatatt atagatgaga atacttcgga attattggtc agtggtcagt
     7921 gtataactaa tggctattta gattatgaaa acacaagtaa atattttata aatgtaaatg
     7981 attgcctata ctataagaca ggagacttag ttgaattaaa tggtggatta ttatatttta
     8041 aaggtaggaa tgataagcaa atacaattaa atggaatgag agtagaatta ggtgagattg
     8101 aaaatagaat tgaagaaatt gaatatgtag atcaatcaaa agttatttat aaaaataaca
     8161 aaattatagc atttatcaag acaaaatatt ttgatgaaga atattttaaa aattatttta
     8221 gtcaaaattt tgagaaacat ctgataccta ataattttca tttagtgtct gaatttcctt
     8281 taaatcagag taaaaaagtc gataaagata ggttaatgta taatttttta gataccgaag
     8341 aatctgatag tatgttaaat gaactagaac tagaaatcaa agatttattt gaaaatgtta
     8401 taactattgg taaagaaaaa ataaccaaaa attctaattt ttttaattta ggtggagact
     8461 cgttgtcgtc agttttactt ttgatgggac ttgaagaaag atttaacatt tcaattactt
     8521 tgagtgatat ctataattat ccgacgataa tgcaactgag taaatatata gattctttaa
     8581 agaagaataa aaatatagat gatgaaccaa agaagaatga gaacattaaa attgacatca
     8641 atactatgac tgcagaattg aaaaatgttg agaattatat ttatcgaagt ggtcagattg
     8701 taagtaagta tgagacatta catttacaaa gagtatatta ttatgataac tttgaaagtt
     8761 ttattgaatt tgaatatgtt tttcaaaaag gagaagcgtt tgaagtagtt gtaggtctaa
     8821 taaatgattt aattgctaac gtaactatgt tacgaactag ttttgttttt gaagatgaca
     8881 agttatattt tgtagaaaaa gcaatggaaa atttggacag tatgccaata tttgatgttt
     8941 catatcaatc tatcgactac attagcgata taaagaaaaa tatcagaatg attttgatgg
     9001 acagtagaaa agaaggaggt ttactaaatt ctttaatttt attaaaaaat gataagcaat
     9061 atactctgat cggtcttatg gaccattcaa ttgctgatgc ctcaactcca gctacaatat
     9121 tggaaattat tagtaaccta aagaatggaa aaaaaatcaa ttttgaatca acttatgaag
     9181 attatattaa gctaattcat aaaaacaata atatgtatga aataatgaaa agttcttttt
     9241 atcaggattt agttaaatgc ggggaagatt cagaatttga gattaaaaag atggagagta
     9301 gtttgaatgt ttacaaagtt gatttagaat ctgatgcgaa atcattaagt actcaacaaa
     9361 tcaatttatt tttagcatat aatatcggtc aatatcttct taaacttttc aatcaacata
     9421 gtattgttat aaaatgcctt gctaatggaa aagactattt aggcactaaa tataagtaca
     9481 cgcttggaga ttttcataca agcatttata ttgttgttta taaagacgaa aattatttag
     9541 attataagaa acgtgtggag gatagtataa aaacaaatta tgtagaaaaa gtattcaggc
     9601 ctacatatgt gtatggtagc aattatccta ttaaaaataa tgatcaaaaa cttctaaaaa
     9661 atagtttaag gcatacaaca aatacctcta tagatttttt aggtataatt aaagaagatg
     9721 atttggagag atatactaaa tctgtaaaac agtctctata tcagctaact cagattgatg
     9781 atactttata tgttactgtt tatctagtaa ataatcaatt agttatctat acaaataagg
     9841 attttttaga ttttgagact tttgttaaac tttaaagaaa aaaatttatt gctaatagaa
     9901 gatatttaga aactccaaaa tataatgaga tataactcta gcaatcttgt aaaatcaatt
     9961 ttcttaattt aaaaaaatta atttttagag gcgccaagta gaaatgcatc ttgcaatatt
    10021 agatagcaaa ttatatacat aaacgaggaa agagtagaat gaaaatttta ttaaacaaat
    10081 acactccaac actagccaag ttaaattatt tagcagatca agatgcaatt gtaattgctc
    10141 cgcttgatac gcagaaaaaa tatgaaaaat accttatgaa aggtaataga ttaccaaaaa
    10201 taatatattt agaagactat acattaccaa agatgatttc aattatcaga gaatctattg
    10261 atgtggatag tatagaggaa gttttaacac ttgatgagca ttatatgtgg catgcgggtt
    10321 ttctaaacga ttacttcaag aaaaaaaatt catcatattt agttaattca ttgtttcagg
    10381 ataaatattt aatgagatct gtactgtttg agatagtacc tcagcctatg tttcgtctta
    10441 ttgagacgca aaaagatatc gaattatttt ggaaaaatac agcaggagat aaatctataa
    10501 ttaaacctcg atttggagca gcttgtgttg ggataaaaaa atattctaga ggtgaacaaa
    10561 ttccggagaa gttcattaat tctcagtata ttattgaaga gtacgtagat ttacaaaaaa
    10621 tgctgacttg tgatggttat tcgcaaggta gtaatataat cagattttac tcacatgaat
    10681 atgaagaatt attattggga acaattggaa ctagtgatga attcacagtc agaacgaata
    10741 gtctctatga aaaaaatatc ccctttttac gaaaaatatt tagtgaatgt agcaaagttc
    10801 ttaaagaatt tgttaatgac tactcaatta ttccttttca ctttgaatgg ttttttgatg
    10861 agaacaaggg ggaatttgta ttttgtgaag taggaaaaag atttggtgga ggcgatattc
    10921 caaatttaat tcaaagaagt tttggtgtta acatttttga agaattttgg ggaaatgtct
    10981 ttgataataa agagctacat ccaagtactg atttagaacg tcctaaattt atttctgcta
    11041 catattgtcc atataaaaaa cgaggaaaac tagtttcggc tcctgatatg gaattatttg
    11101 aatggactga tgagatatat gtattttcaa aagtaggaga ggagtcagat ggtataactt
    11161 ctgtagtaga aggagatttt attgcaatta ttgtaagtga gaccgaggaa caacataatc
    11221 aaaaattgtc taaactacgg gaactatctg agcagtttat atgggaggaa cgttttgaaa
    11281 gacgttaaga aaaagaatat tttatactta gttagtagta aaggggtgtc tcgtatagga
    11341 gatactatgt ttgattttgc taacaataca tttcttgctg ggattaatcc aacttcacta
    11401 tcattagttg cagtatatca gtcgctagaa agtgtgatag gtgttctatt taatttattt
    11461 ggtggtgtat ttgcggatag ttttaaaaga aaaaaattat tattgctaca aatatcttgt
    11521 gtggtattgc ttgcttagta ctttcattca tatcacaaga tcaatggttg gtttatgcaa
    11581 ttgtactaac taatgtaatt ttggcattca tgagtacttt ttctggacca tcttataaag
    11641 cttttacgaa agaaattgta aaaaaggata gtatatcaca acttaattca ttgctagaga
    11701 caacaagtac tgtaattaaa gtaacaattc ctatggtggc aattttttta tataagctac
    11761 ttgggataca tggtgtgtta ctattggatg gattgtcgtt tctaatagct gctttactaa
    11821 ttttctttat tgtacctatt aatgaagcag tggtcacaaa ggagaaaatg acattcagag
    11881 gaatcattaa tgatttaaaa attggattta agtatgttta caatcataag tcaatcttta
    11941 ttattatcgt actttctgca cttgttaatt tttttctagc tgcttataat ttattattgc
    12001 cctatagtaa tcaaatgttt ggagaaattt caactggact ttatggcacc tttttaacag
    12061 cggaagcaat cggcggattt attggagcaa tattaagtag ttttgtgaat aaaaagttat
    12121 caagtaagaa attaatgttg tttctatctt tatcaggact agtgttaatg ttagctactc
    12181 cgttttatat tatgtttcat aatgtaatta ttttagctat ttctccagca ctttttagtt
    12241 tatttctttc tatctttaat attcagtttt tctctattgt tcaaagagat gtcgataacg
    12301 aatttttagg gagagtgttt ggtattatat tcacagtagc tattcttttt atgcctattg
    12361 gtactggttt tttttcggta gtattaaatc ctaataatac ttttaatctt tttattattg
    12421 gtgcgtctat tacagtatta tcgctggtat ttggaatact atttaaaaga tataatatga
    12481 gttgaaatat attactaagc gaaaataagt aagaaattac ctcaaaagaa aataaaagca
    12541 cagagctaat ataaactgca ccccaaaagt tagacagaaa aatcggctct tttctaccat
    12601 ttgtcaagtc tatcaaggct ttaagtaaaa aaatgagcta agacagtagc tattatgggc
    12661 tctttgtcaa ctgtagtggg tgacgaaaag ctaacatcta gagaggaccg gataggtcct
    12721 ctttttatgt atgttcagtg tgatgaagac acgtttctta aagttgatga agtttctaaa
    12781 accgaagccc aagcgtttaa tgtctttaat taacttatta gtcgcttcaa gttttgcgtt
    12841 tgaatagtct gtttctagtg cattttggat gtattgcttg tgtctaagaa aagtcctaaa
    12901 gaccgtttga aaatagtgat tgaccttgct tctattttcc tctatcaggt caaagaactc
    12961 acctactctc ttctcctgaa aatgaaaaag taagatctga taaagtgtat agtagtcagt
    13021 aagctctttt gaaaagacta gtgtcttctt aacaacttca tgtggtgcta aagtttggcg
    13081 gaaagtcttt gaatagaaag agttgagaga taacttacag ctgtcctttt ggaagagtcg
    13141 ccagtgattt ttcaaggctc gatagggtag tgacttctta tcgaactggt tcataattgc
    13201 aattctagtc tttaaaaagg cacgtccaag gtgctggatg atgtggaaac gatcaagaac
    13261 gatttttgcg tttggaaaga gcttgcgagc cagtggaata taagctccag acatatccat
    13321 cgtgataaac tgtacctgtt gccggacttt caatggatac ttcaaaaagt agtttcgtat
    13381 agtagtttgg cggcgattat caaggatggt tatgagttgg tttgtctcat aattctgcgc
    13441 cacaaaagcc aattcccctt tcttgaaccc aaactcatcc caggacataa cagcagggag
    13501 tttgtcataa tgttcct
//
