LOCUS       gnlProkkaNCNHKHDH_72    6795 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NCNHKHDH_72.
ACCESSION   gnlProkkaNCNHKHDH_72
VERSION     gnlProkkaNCNHKHDH_72
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 14:43:15
            Original ID  :: gnl|Prokka|NCNHKHDH_72
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6795
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6795
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[3556:6448]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3557..6448
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..6795
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6795
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(680..1888)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 278.7; E-value: 1.3e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MNKKEQQNTYLLVGSRIISRVGDIMFDFANNTFLSSVNVKSLMLV
                     GIYQTLENIISVIFNLFGGVLSDNFQRKRIIILTDILSGVLCLALSFISNQQWLIYAVV
                     ITNIILAFFSSFSGPAYKAFTKEVVEADNISKLNSLLESFITVVKVVVPLVSVSLYGLL
                     GLYGILRLDGITFIASGLLILFIRPILEESTGKQVFSLSKIFSDLFEGGRYLASQKEIL
                     YLVILSAIVNFFLAAYNLLLPYSNQMFPRVTVGLYGVFLGAEAVGGLIGASLSSILNKV
                     LKIKTMILYLGVSGVFLSLTPMVYCVFPSAYMLALYPALFNLFLTMFNLQFFSYIQKNV
                     DNVFLGRVFGIIFTVAILFMPIGTMTFTFLLSPKNIFNFVIVGLSIGGISLLFYRIFSK
                     RLR"
     CDS             complement(1914..3560)
                     /locus_tag="ctg53_2"
                     /transl_table=11
                     /translation="MSIYKDIVEGYQLNNIQEKDKLNNVLVQLNEKDDQEMINRKNFIG
                     HFTASAFVISKDNRRLLMVHHNILKRYLQPGGHIDKNDRNPLDAAKRELFEETGIDSEI
                     LTYQCAEPLNSLIPFNVSVHKIPENKLKNERSHYHYDLQYLFYIENEVDVKIDSNESSS
                     YEWIQLDNVKDMDGYKEIIKKIEKLEAASQERFLSNMLKGASFEDISCITVQHIIPSTI
                     PIIMTLQKIFGHRLLVCAKPNSVDKMVWHKLENMGVRLTLASRDEYFNVDYLGIKSKTI
                     LLDIGGYFASIAQIPNLPIECIIEDTENGIQKYENVIDQIEYPLFSVARNPLKKNEDYL
                     VGADIVFGTDYILHQKNLLMQYMQVVCIGYGKIGYGICTKLRELGIRPKVLEKDSMRTI
                     QAVRDGCDILLEKDFKNIDLIFCATGSKSLDILDFRSIKDGTFLVSATSSDDEFNYSYL
                     LDEYEEIVETSLITRYESEDNYFYLLNQGTPTNFVVNSALGNYILLVQAAILYTAKKFI
                     EDREMAIAKQVNTLSDEDNYNIAKQWLEEFC"
     CDS             complement(3557..6448)
                     /NRPS_PKS="Domain: AMP-binding (6-388). E-value: 7.5e-65.
                     Score: 210.9. Matches aSDomain:
                     nrpspksdomains_ctg53_3_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     172.5; E-value: 2e-52)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="AMP-binding (E-value: 9.9e-65, bitscore:
                     206.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.5e-07, bitscore:
                     20.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILKTFSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLL
                     NSDEETVPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDR
                     DVKLENHSVTLLLLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNID
                     WLVKEFYKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGET
                     IEKKKITHLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRV
                     FNLYGPSETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVT
                     EGYRLQPELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQVNGIRIELDEVK
                     SIVDKLKSVKSSRVVFYKKKLVVFYEADLNIKEDIIRSLPSYLNPTVVKVESYYLNQNR
                     KLDVPKMLEIYYYKKQSQQGDDVRKNILDVLSKFERVDITDLDSLELVRFYLEIEDIFD
                     IEIKENDFYRLKSVDSIVDYIRNKSFFQERSTEPNDSFTKEHDLVNLEYNLTKMNYRYL
                     KNIITPSPTQKRLYKNNQNRVIGFNLALEEVTYLELNKLHHIIKYLSYKIDIFRLVVEK
                     EQTRFSIGIVNEGDYSPNIIVLNNLPTELELQGILDNIEVIPIPIIVVGTRDKKVRFYF
                     PYHSIDASSLNKLGDTVYQLYEKKIVIDEVPSSSLVAFSQFKREVLQNDVSGDVLARLP
                     KIKPAIEFEKLNDEVQCFQVSLPEDIKGDDVYLFTIYAISQCILSDYNLSAISGGLSLD
                     FRDYEQFDAYDLIGDIHKKIPFQVNRTETFEEFKNSHFKILEIYRTGIDYYEIAMLGND
                     MSAKEVQERLNNLSLSINFIGEAFRLKDTINNIIDVDFDKNFINVFVHERFAYAVIKSE
                     LLSNSVYDLMHKDSKFELKVIDKKRLENEETNR"
     CDS_motif       complement(4628..4675)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg53_3_0004"
                     /evalue="1.30E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg53_3"
                     /protein_end="607"
                     /protein_start="591"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="NNQNRVIGFNLALEEV"
     CDS_motif       complement(5255..5311)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg53_3_0003"
                     /evalue="2.60E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg53_3"
                     /protein_end="398"
                     /protein_start="379"
                     /score="20.0"
                     /tool="antismash"
                     /translation="SRIDSQVQVNGIRIELDEV"
     aSDomain        complement(5285..6430)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_3_AMP-binding.1"
                     /evalue="7.50E-65"
                     /label="ctg53_3_AMP-binding.1"
                     /locus_tag="ctg53_3"
                     /protein_end="388"
                     /protein_start="6"
                     /score="210.9"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="FSDTVKQYPSKVAVMYSGGEFTFQEVDVMSNFIAKQLLLNSDEET
                     VPFYIEKNKYVLPVVLGIMKSGKIPLPITNSLEVKISLERISEVVFDVLISDRDVKLEN
                     HSVTLLLLPKKLESYSEYQEVATTKENEIAHIICTSGTTGVPKKVFLTDDNIDWLVKEF
                     YKIVKFTSESKFLFTTPYTFDVSLTEILAPVYTGGTLVCYDGGIQNIIRLGETIEKKKI
                     THLSLSPSFAETIIDISGPEVFQNLRALCLAGETFPSSLANRLRGLIQQGCRVFNLYGP
                     SETTIYATYYELKDRKYNTVPIGKPLPGVQLKIASQKENSKMAELLIGGNGVTEGYRLQ
                     PELNKAKFKLIGSNRYYVTGDYVYYQGDNLVFSSRIDSQVQV"
     CDS_motif       complement(5387..5458)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg53_3_0002"
                     /evalue="2.80E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg53_3"
                     /protein_end="354"
                     /protein_start="330"
                     /score="19.7"
                     /tool="antismash"
                     /translation="ELLIGGNGVTEGYRLQPELNKAKF"
     CDS_motif       complement(5975..6031)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg53_3_0001"
                     /evalue="1.00E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg53_3"
                     /protein_end="158"
                     /protein_start="139"
                     /score="15.1"
                     /tool="antismash"
                     /translation="AHIICTSGTTGVPKKVFLT"
     CDS             complement(6638..6793)
                     /locus_tag="ctg53_4"
                     /transl_table=11
                     /translation="MADNQKDLQKFVNKRLEELQKDGTLAKLAEKFFGNKDYIPTKDAL
                     KVPSKK"
ORIGIN
        1 ttattgtaac agaattcact aagcttaact aatacttaaa cataatcaaa gtgataagaa
       61 aatactatca cctaaaaata tcaattgttt gacaaagagc cgaattgctt cgtctttctg
      121 aacgcagacg ggttgtctta aacgacatgg tagctctagc tcagccttta ccagagtatg
      181 acatcttacg gtcaattcct ggcatcgcag aaaccacagc gacatctatc attggcgaat
      241 tgggagatat tcgtcgcagt ataccaatca aatcaacgct tttattggca ttgacctgag
      301 acactatgaa tctgggaact ttctcgctaa ggaacacatc actaaacgag ggaatcccta
      361 tgccagtaaa atcttgttca agtacattca caacatcgct tcagctagtc ataccaatcc
      421 ctgcaatatc gctgactttt atgagaaacg aacaagacat ttagagctat ttctaaacta
      481 atcggcgacc catctactgt ctctaaaaaa gtatgtaaac accttaccat caaggaatca
      541 atcaacactc aaaatgtgag gcccgcccac ttctaaaacg attaccttat gtgtgtaatg
      601 gttgccctaa caagtatata aattgtgact ttactaagca attttactac gccatcggag
      661 ctaaaattac tctgaaaatt tacctcaatc ttttgctaaa aatcctataa aagagaagcg
      721 aaatacctcc tatagataaa ccaacgataa caaaattaaa gatattttta gggcttaaaa
      781 gaaaagtaaa tgtcattgtc ccaatgggca taaataaaat tgcaacagta aaaataatcc
      841 caaaaactct accaagaaag acattatcca cattcttttg gatatatgaa aaaaactgta
      901 agttgaacat agtcaaaaac aagttgaata aagcaggata taacgcaagc atataagcac
      961 ttggaaaaac acagtatacc ataggtgtca aagatagaaa aacacctgat actccaagat
     1021 ataaaatcat tgtttttatt ttcaaaactt tattgagaat actgcttaaa gacgctccaa
     1081 taagaccacc tactgcttct gctcctagga aaacaccgta taagccaacg gtaactcttg
     1141 ggaacatctg attgctatat ggtaacaaca gattataagc tgctaaaaag aaattaacaa
     1201 tcgcagataa aataaccaag tacaaaattt ccttttgact agctagatac cttcctcctt
     1261 caaaaagatc tgaaaagatt ttcgataatg aaaacacctg tttcccagta ctttcttcaa
     1321 gtatgggacg aataaagaga ataagcaacc cagatgcaat aaatgttatc ccatctagac
     1381 gtaaaatacc atataatcct agtaaaccgt atagagatac cgataccagg ggaacaacga
     1441 ctttaactac cgttataaac gattctagta atgagtttag ttttgaaata ttatctgctt
     1501 ccaccacttc tttagtaaaa gccttataag cagggcctga aaatgatgag aaaaaagcta
     1561 atataatgtt tgtgataacc acagcataaa tcaaccactg ctgattagaa ataaaagata
     1621 aggcaagaca caatactccg cttaaaatat ctgttaaaat gataatccgt tttctttgaa
     1681 agttatcaga cagaacacca ccaaaaagat taaaaatcac actgatgatg ttttctaatg
     1741 tctgataaat accaactaac ataagtgact taacatttac actcgataaa aaagtgttat
     1801 tcgcaaagtc aaacataata tctccaacac gagaaataat acggctccct acaagtaaat
     1861 atgtattttg ttgttctttt ttattcaaaa taaactcctc agatatttgt tcattagcag
     1921 aactcttcta accattgctt cgcaatatta tagttatcct catccgaaag agtgtttact
     1981 tgcttagcta tagccatttc tctatcttca ataaacttct tagctgtata tagaatggct
     2041 gcctggacta ataaaatata atttcccaaa gcggagttta ctacaaaatt agttggtgtt
     2101 ccttgattta acagatagaa atagttgtct tcactttcat atctagtgat taatgaagtt
     2161 tcgactattt cttcatattc atccaataaa tagctataat taaattcatc atcactagat
     2221 gttgcagaga ctaggaaggt tccatctttg atagagcgaa aatctaaaat atctagactt
     2281 tttgaaccgg tcgcacaaaa aatcaaatca atattcttga aatctttttc tagcaaaatg
     2341 tcgcaaccat cacgtaccgc ttgaatagtt ctcatgctat ctttttccag caccttcggt
     2401 ctaataccaa gttctcttaa tttggtacag atgccgtaac cgattttccc atatccaata
     2461 caaaccactt gcatatattg cattaataaa tttttttgat gtaatatata atctgtccca
     2521 aaaacaatat ccgcaccaac taagtaatcc tcattcttct tcaggggatt tctagcgaca
     2581 gaaaataacg gatattctat ttgatcaata acattctcat atttttgaat cccattttct
     2641 gtatcttcaa tgatacactc gataggtaag tttggaatct gagcaattga ggcaaaatac
     2701 ccaccaatgt ctaataaaat tgttttactc tttatcccca gataatctac attaaaatat
     2761 tcatcccttg aagctaatgt taatcttacc cccatatttt ctagcttgtg ccataccatc
     2821 ttatcaacag agtttggttt agcacacact aacaaacgat gcccaaatat tttttgcaat
     2881 gtcatgataa tcggtattgt acttggaata atatgttgta cagtaataca tgatatgtct
     2941 tcaaacgatg cacctttcag catattagat aaaaaacgtt cttgagaagc tgcttcaagt
     3001 ttttcaatct tcttaatgat ttccttatag ccgtccatgt cctttacatt atctagctga
     3061 atccactcat aggaactcga ttcgttgctg tcaattttca catcaacctc attttcaata
     3121 taaaataaat attgcaagtc ataatggtag tgggaacgct cattcttcaa tttattttct
     3181 ggtatcttat gcacagaaac attaaaaggt atcaagctat tcaatggttc tgcacattga
     3241 tacgtcaata tttcagaatc tatcccagtc tcctcaaaca gctcacgttt cgctgcatct
     3301 agcgggtttc tatcattttt atcaatatgc cccccaggct gtaggtatct ttttaaaata
     3361 ttatggtgaa ccatcaataa acgcctgtta tcttttgaaa taacaaatgc tgatgctgta
     3421 aaatgcccaa tgaaattctt tctatttatc atctcttgat catctttttc attaagctgt
     3481 accaaaacgt tattcaattt atccttttcc tgaatattat tcagttggta cccctctact
     3541 atatctttat aaatactcat cggtttgtct cctcattttc cagtcgtttt ttatcaatta
     3601 cttttagctc gaatttgcta tctttatgca ttaagtcata aacactatta ctcaataact
     3661 cagattttat aactgcgtat gcaaatcgct catgtacaaa tacattaata aaatttttat
     3721 caaaatcaac atcaattata ttattaatag tatcttttaa cctaaatgct tcgccaatga
     3781 aatttattga tagagacaga ttatttaatc gttcttgcac ttctttagca ctcatatcat
     3841 ttcctaacat tgcaatttca tagtaatcaa tacctgtacg atagatctcc aaaattttga
     3901 aatgagagtt tttaaactcc tcaaaagttt cagttcgatt tacttggaat ggaattttct
     3961 tgtgaatgtc tcctattaag tcatacgcat caaactgttc ataatctcta aaatccaaag
     4021 atagaccccc agatatagca gacagattat agtcgcttaa aatacactgt gagatagcat
     4081 aaattgtaaa aagatataca tcgtctcctt taatatcttc tggtaaagaa acttgaaaac
     4141 attgaacttc atcatttaat ttctcaaact caatagcagg ctttatcttt ggcaatctag
     4201 caagaacatc cccagagaca tcattctgta acacctccct tttaaactgc gaaaaagcaa
     4261 ccagtgaact actaggtact tcatcaataa ctatcttttt ttcgtacagt tgatatactg
     4321 tatctccaag tttatttaat gatgatgcat caatagaatg atatggaaaa taaaatctta
     4381 cttttttatc tcttgttccc accacaataa ttggaatagg aatcacttct atattatcta
     4441 atattccttg taattctaac tctgttggta aattatttag tacaataata ttaggtgagt
     4501 aatctccttc attcacaata cctatgctaa atcgagtttg ctccttttcg acaacaagtc
     4561 taaatatatc aattttatag cttaaatatt taataatatg gtgcagctta ttcaattcta
     4621 aataagtcac ttcttccagt gctaaattaa aaccaataac acgattttga ttgtttttat
     4681 aaagtctctt ttgtgtcggg ctaggagtaa taatattttt caaataacga taattcattt
     4741 ttgtgagatt atactctaaa ttaaccaagt catgttcttt agtaaaacta tcgtttggct
     4801 cagttgaacg ttcttgaaaa aatgatttat ttctaatata gtccacaatc gaatctacac
     4861 tctttagcct ataaaaatca ttttctttaa tttcaatatc aaagatatcc tcaatctcta
     4921 aataaaatct aactaattct aacgaatcca aatctgtgat atcaactctt tcaaatttag
     4981 atagtacatc taaaatattt tttctaacat catctccttg ttgactttgt tttttataat
     5041 aatatatctc aagcattttt ggaacatcca actttctatt ctgattgaga taataactct
     5101 caactttaac taccgtcgga tttaagtaac taggtaaact tctaataata tcttctttaa
     5161 tattcaaatc ggcttcataa aatacgacaa gtttcttctt ataaaaaaca actcgtgatg
     5221 atttaactga tttaagttta tctacaatag attttacctc atctaattca atacgaatac
     5281 catttacttg gacttggcta tctattcttg aactaaatac caagttatct ccttggtaat
     5341 aaacgtagtc ccccgttaca tagtacctat ttgaacctat caacttaaac ttagctttat
     5401 ttaattcggg ttgtagtcta tacccttccg ttactccatt accaccaatt agaagttctg
     5461 ccatcttaga attctctttt tgagaagcta tctttagttg aaccccaggc aaaggcttac
     5521 caattggaac agtattatat tttctatctt tcaactcata gtaggttgca taaattgttg
     5581 tttctgaagg cccatataaa ttaaatactc gacacccttg ctgaataagc cctctcaacc
     5641 tattcgctaa tgaactagga aatgtctcac ctgctagaca caacgctctt aaattctgga
     5701 atacttctgg cccactaata tcaataatag tttcagcaaa agacggagat aatgataaat
     5761 gagttatctt ctttttctca attgtttctc ctagtcgaat aatattctga atcccaccat
     5821 cgtaacaaac caaagtacca cccgtatata caggtgccaa aatctctgtt aatgaaacat
     5881 caaaagtata gggagttgta aataaaaatt ttgattcgga agtaaacttc acaattttat
     5941 aaaattcttt tacaagccaa tctatgttat catcagttaa aaatactttt ttaggaaccc
     6001 cagtagttcc agaagtacag ataatatgtg caatttcatt ctctttagtt gtagctactt
     6061 cttgatactc actgtaactt tctaattttt tgggtaagag caaaagagtt actgaatgat
     6121 tttcaagttt aacatcccta tcacttatca acacgtcaaa gacaacttcg ctaatacgtt
     6181 ctaatgatat tttgacctca agactatttg ttataggtaa cggaatttta cccgatttca
     6241 ttatccccaa aacaactggt aaaacatact tatttttttc tatataaaaa ggtacagtct
     6301 cttcatcgct attgagtagt agctgcttag caataaaatt agacatcaca tctacttctt
     6361 gaaaagtaaa ctctcctccg ctatacataa cagcaacttt agaaggatat tgtttcaccg
     6421 tatcactaaa agtttttaat atggtcattt ctcttctcct taatttgatt gattatgcac
     6481 tgtcattcat aatttatcca cacacaacaa taagaatttc aaaagcaatt ttcaaagttg
     6541 gcaaaaattt tacctttttc atcatttccc tcttttattt atcatataat aaacaaaggc
     6601 ttttcgtcac cgactacagt tgacaaaaga gactttctta ttttttgctt ggaactttca
     6661 aagcatcttt agttggaata taatctttgt ttccaaagaa tttttcagcc aacttagcca
     6721 aagtaccatc tttttggagt tcttccaaac gtttgtttac aaatttttga agatcttttt
     6781 gattatctgc gaaca
//
