LOCUS       gnlProkkaCIIEEHFO_28   17049 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIIEEHFO_28.
ACCESSION   gnlProkkaCIIEEHFO_28
VERSION     gnlProkkaCIIEEHFO_28
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 15:04:33
            Original ID  :: gnl|Prokka|CIIEEHFO_28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17049
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17049
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4624:7049]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4625..7049
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17049
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17049
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             515..616
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             786..1055
                     /locus_tag="ctg15_2"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1215..1514
                     /locus_tag="ctg15_3"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1614..2525)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_4"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2755..2844)
                     /locus_tag="ctg15_5"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2841..3452)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_6"
                     /sec_met_domain="TIGR04085 (E-value: 5.7e-16, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDMLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERIS
                     KGEFKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGV
                     RACSINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCS
                     ECPLPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3537..4628)
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4625..5944)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_8"
                     /sec_met_domain="Streptide_RRE (E-value: 4.8e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.4e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.3e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.8e-14, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6014..6106)
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6189..7049)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_10"
                     /sec_met_domain="TIGR01716 (E-value: 2.4e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7289..8125)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8119..8685)
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8864..9022)
                     /locus_tag="ctg15_13"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9175..9687)
                     /locus_tag="ctg15_14"
                     /transl_table=11
                     /translation="MAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGESNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             complement(10087..13266)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 494.8; E-value: 9.1e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg15_15"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNHYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13263..14489)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.1; E-value: 1.1e-76)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_16"
                     /sec_met_domain="Metallophos_2 (E-value: 3.1e-10, bitscore:
                     31.3, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEEVVMKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEK
                     VDGVIISGDLYDRAVPPVDAIKLFNKTLTRLVLEEQIPVYAISGNHDGAERLHFGRDFF
                     QHQGLHLSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYIL
                     EDIEKAFDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFD
                     YVALGHIHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLE
                     VKRPIVVLQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTD
                     IVEITFSRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESV
                     FEEIERSRQ"
ORIGIN
        1 ttatcagata attgacggta aaatgacaat cctggagaag taatttaatt tatgactaaa
       61 aatcagcaaa aatataatta tgactaagga atattttatt aactaaatgt tgagatagca
      121 caaggaaata tttgtgctat cttttttatt tattaggaaa agagaaaaaa ttatgccaac
      181 gaaaatatgg ttaaaaccag aacaattaga tttgtatatt aaacatttag aacgatttag
      241 agacttatat agtaaactag actgttctgg tatagtaaat ttgtaacact cctacctaat
      301 aagttaaact attcattaga ataggagaca taacatgaaa cactatccag acgaaacacg
      361 ataaaaaatt gttcgactgc acattcaaga cggatgaaca ttaaaaagct tagctgctga
      421 atatggcgta tcccaagcct caatctctaa ttgggtaaga cattatcgca aagaatgcca
      481 aactaataat aaagaaaaat cacagcttga actcatggag gaggttcgta aattacgtca
      541 agaaaaggca gagcttgaaa aggaaaatga tttcttaaaa aaagcagcgg cattctttgc
      601 aaaggaaatc gattagaggc atatcgtttt attgataact ataaagaaga ttttggtttg
      661 cgttggttgt tcttgcatat gaatattcat cccaatgctt attataatta tcttaaaaag
      721 acaaggacta actatcatcg tcaaaagaaa gctattctta atactattcg agatatctac
      781 catgagtgca atggaaagaa gtaaatcaat tcttcgaaac agaaagcatc aaactttctg
      841 atatagagcc ttcgaaagtt agttataggg aggtacaaag gaatcaaatc aataccacta
      901 tttataatga aaaaggtaat ataaaggata ttgatactag cattataaga gatatgtacg
      961 ataaaagcaa acctacttta aaacagggag cctatatatc cgctatagca gcttctctag
     1021 aaggggggta ctgcatttat aacagcaata attaaaaaaa gcgcttaggg aaaactatta
     1081 gtgagtttac aaaagacgat tgtcttgaaa tttctaaaga tagtggaatt ggagctataa
     1141 aaggaagtac tcgaggcatt acgatatacg ccctaacgaa ttacacagct actcctgcag
     1201 cagtagcaag ttcattgtgc actgcttcat ttggtatcgc taaagaagca tacaaattcc
     1261 gtaaaaactt aatcacaaaa gaagaatttt tactaaattc gcaaatatta tgtgttgaag
     1321 tatcagttag tgcattatcc tcaatattag gacatgctgt aattccaata cctattttag
     1381 gatccgttat tggaaataat ataggaactt tcctatatga aatcgctaaa gataatctca
     1441 caatgaaaga gaaattactg atagcagatt atttcaaaga gatacaagaa tataactatt
     1501 ttttagataa ttaatttgaa ttatataatc atcaacttca gagagattaa gaattactat
     1561 aaacttttag ggaaggcatt ttctcctgac tataatatcg cttttcaggg atcttatgaa
     1621 tttttaaata tgttttttaa aaatacgtta acctctccta ttttctctgc ttcaggtaaa
     1681 tagatagaaa cggttgtcga ataaacaaaa gaaggtacac tcacaattga aagcaattga
     1741 ctaataactg cataaatagc caacaattct actcctaatc tcgacatcaa ggcatcaaac
     1801 accataataa acaaaacact ctccagaatt tcttgaccaa ccaaaggaat accaaatgtt
     1861 attaattcaa atttagttgt agatgtaatg gataaagcct tcaaaatcat tggataaacc
     1921 ataaacaagt aactaagcga tatgaaagct aaggatacaa tcgttgatat ggctgctccc
     1981 ttaattccga tttgtggtac cagtacataa tttaacacaa catctattaa tgaactgata
     2041 agtccaaccc acataattgg ttttgttttc ttttgaactc ttaataaatt tgtcagcgaa
     2101 aagtttaata atgtcaatcc gatatatgga gacatgaaga ctaaataaat ggtggataag
     2161 gacaatagtt gccctttaaa tccatagagc tgcttcaaga ttacatttcc aaaaataatg
     2221 acaaaaaccg caaaggcaac tccgataatt aaatctaagg ttagatttga tttcaataaa
     2281 tcatcaaacc tgttagtttg ccgattagag tacgccttag agcttttaat attaaatgac
     2341 aaactgaatg ctcctaaaag tccaccaaaa gcaaataaga gattctgaat aatggaaatt
     2401 cctgacagag caattgagga attgttcaca gcaaaatgca atgctatctg cccaataatt
     2461 acttgaccaa tatttgttaa aactaaggga aaggcaaatt tgttaatttc ttttgaatct
     2521 atcatttttc ctctctaaaa ggcttcaaat gtaagtaaag atcagattta actaaatttg
     2581 cataaataat atgcaaaata ggagtttctt ctaaaaatga aataattgcc tgcttacaat
     2641 cattagcaga tacctcataa tcttgctgta atagttctac aatcttgtct aaagaaaaat
     2701 ttttagaaat gcaataaagt atttctgctc ctatttcatc aaatgaatag tactctaatc
     2761 aagtagatcg tatcctatgt attcatctgc tactttattt acaatgaaat ctctcttacc
     2821 tcttatcaca aaatgttctt tcatacgact actccacctc ctttttgttc ataaaagcag
     2881 gctaaatcag agcccagtaa cgttccatct aattccaagg cactgcatcg acatccccca
     2941 ccacaccatg gtaggggaca ttctgaacat ttcccagaaa tatcatcaaa tgtaattgat
     3001 cttagtttat taaatacagc agaatggtgc caaatttcgc taaacttttg ttctttaaca
     3061 tttccagcaa ctaattcatc tataccattc atcaagtcac acccgtatac atctccttta
     3121 tgattaattg aacatgctct aactccagct tgacaagata tttcccttgg cttatcaaaa
     3181 tttatatcta ctttttgatg ccaaacattt tctaataaat ctgatctatt ataaaatgca
     3241 agcggaaaat aatgtgtcaa aaaaacatca ctttcattag gaggaacaat tttaaattta
     3301 actttgaact ctcctttaga aatccgctct gttaaatcaa gaaaaacagg ataccattgt
     3361 tttttatctg ctaaaatact accgtcatta gccctaccag taggacaaat aaccataact
     3421 gacatatact caataccaag catatcattc aatcttatac tctaaagaaa atatctgcta
     3481 aatttgcaaa caattgtgct atcaataatt tggcaaatga attagaaata caacttttaa
     3541 gttcttttct ctctgttaga aaatgaataa gatactaagc aacaaagagc tactatacca
     3601 aatattaaat aattgctcct aatactaaag ttatcagcaa aaataccagc taggaaatca
     3661 gctaacataa aactaatcga aataaacaaa ttatatactg accatgatac tgctctattt
     3721 ttttctattg acatattaaa tttataataa aaatgattat tgtagttgga attaagaaca
     3781 cgcattaata aaaggattat aatttggatg attagattag tttgaaaaaa catgagtata
     3841 gctaatactg gtaacatcaa gcttacttca aacttaattt ttagataact ccccaaagcc
     3901 atagatatat taaacataaa tagtataatt cccagcatat ctagtgaaag tccctgttca
     3961 tttaagaata tccctgcata agaattgcta atcataatta gagttgagaa tgctactcct
     4021 aatattatta ataaccatgg aatattttga atattatcga ggctaaaaaa tttttgttta
     4081 ttattttgtt cctttttaat ctcgggtaat cctattaaat ataataaact gaaaattaca
     4141 aatacaatgg atataataat aggataaata taattcctat gcaataaagg tggagatata
     4201 atcgtaataa tagcaataaa aatatatttt aatgtgttga gatttttcaa aaatgattta
     4261 tatacaactt cgtcatcaat tatttcaaaa ttataagaaa taagaactcc tgaagataat
     4321 gattctgaca atccaaaaaa tatcgctgaa atatatatta tatttgattt tccaaacaat
     4381 aggccccata atgctaaaat taataataaa tttgaaatag ccaaaatttt cttgtaacca
     4441 atcttacttg aaatataact taaaggaata tcaaaaactg agccacatag ctcagtaata
     4501 actgataaag tagctatttc tgtgaacgaa aaacctaagt gctttaatag taaaattcct
     4561 acaaagtagt acggtaatcc agatagaaac atattcattc cgtataaatt aaaaatcttc
     4621 ttactcataa gttacaaact gggtctctaa aatattttgg actcttctcc ttaatcaagt
     4681 taacatagca gccaccctcg caaattttta acaatccaca agataaacac ttagaattct
     4741 tcgttctaaa agaacgaatc cctccataca acggatcatc ataccaaaca tctaacaaat
     4801 ctttttcaaa ggcattctgc ttagtttgat taactcctaa aaaagcaatg caaggcaaga
     4861 tatccccatt agacattatt tccatcttag tatattttgc acgacatcca taatacattt
     4921 cgccaaactc tgaaaattca attgaattat ttatcaactc cggataagcg gtgaaaagat
     4981 gacatccctc agtagcaaaa tttaaattag cttcccgttg agttatataa tctgtaacat
     5041 actcattcaa ccttctcaaa tcagctaaat cgtatttttt ctttattttc gtatatcctg
     5101 ttacctcaga ataattagct actgaaaatc tatctatttt attctctata caaaaatcaa
     5161 ccaattctat aatctgctca tagctttgct ttgtatacac tgcattaatt ctacattttt
     5221 ttccaacctc tttaaagtac ttcgctaatt taatttgtct atcaggtctc acccccatta
     5281 attcaaaatt taatttagga tctaaagtct gcaaagataa aaccggtgta atatatttag
     5341 atttagctag aatttccact gtacttttct ttattaattg ggcattagtt gttatagtag
     5401 tctttatctt cagttcttca caagctatca acaaattatc aatatcaaaa tatctagtcg
     5461 gttcccctcc taaaattgaa acacttaaca ctccattatc ttttgcttgg cgcaaaattc
     5521 tttcccaatc tttagcaggt ttggcatttc tatcttcacg atttgctaaa aaacaaaaac
     5581 cacattttaa atcacagtac atactggggt atattactag ttcaagcgga aaactcaata
     5641 tgttatgttt ttttaatttt gctacatgct ttctcgcatt ttgaagagtc tcgtcaggat
     5701 ttttcgatga tccctcaata ttattatcag aatagatatt taataagagt actcgctcta
     5761 gtttccctgc ttttatttct ttcttaaaaa aggacgtagc aatttcaaaa ccatgatttt
     5821 gaaccaaata aagaaaataa gcttcactct catctaactc aattcggtca aaagttactt
     5881 tatttatcaa aattccacca aacttttcta gtctaaataa aaaatcttct gaaattgtca
     5941 tcatattgaa tacctttcta aaaaagcaga ggaaaatata gcctctgctt aacttatggg
     6001 ataaattact ttatcactcc cagccgtcac cttttgccat caccttccag ccgtcacctt
     6061 ttgccattga actagactca aggacttttt caagctcttt agacatattt ggtactcctt
     6121 tcgaatatga tactgtgatt atatttcttt tcaacactta caataaaata ttcccatatt
     6181 tgcattttct aactactagc taaaattttt tctaaatgtc cttcataagt ctttgctaag
     6241 tgatgacttc ctgctaattt catcgctcca acacacttct tcatttcaat aattgctttc
     6301 acatttccat cctctttata ttgataaaga ttttgtgcat acttaaagac taaacgttca
     6361 tatacttctg tctcaataaa aaagcattga tttagctgct tttcaaaata taaagcatcc
     6421 ataaattttt ctctttcaac acatgtaata tatccattta aaagcatcgt tgaaattaat
     6481 cgtctgttat ttggaatttc tttgtaaaaa tcagaacgcc taaacatttc tcttgctaag
     6541 accatgaaaa catcatgatt taatacatct aaagtattcg agaaaatcaa taactcatag
     6601 tacccccagt attctacact aaagagataa tctgttaaat atgtcaaatc atcctttgta
     6661 tagtaagttt ctcctgataa atcctgtaga cgaattttca ataaaataat attgatttga
     6721 tgaaattttt ctcgcctatc ttccagttcc atctgagaat aaagtaattt tttcatacct
     6781 tctacgtcac gtgttgacac aaaatgacgt actttcgata acagttcgtt taactcatct
     6841 ctatgaaaat catggaccgc atacataaat tcatctattg gcatattgat ttcatctaaa
     6901 ataaacatga actttgaaat cgttaaatct gtttctcctt tctcaaatcg agagagctga
     6961 gacgttgata taccagcctt tgcgacgtct tttaatcgta atcctctcga ttctcgaaac
     7021 tttttaaaaa tttctccaaa ttttttcata ctacacctcc atcacgcata tatgggaata
     7081 attttcattt gctttcatca tatcatacaa taaagaaaaa caaaagtgag gattatcaca
     7141 tgaaaaagca aattttacta acacttcttc ttgtcgtatt tgaaggcatt atcgttatcg
     7201 tcgtgggata aagagtctgg gacaaaagtc ctttagctcc aaaaagcaac ggcataatgt
     7261 actgacccca aaaagttaga caaataattt aagtaaagga tttagttctg tattgtacag
     7321 gactgagtcc ttttagtttt accttaatgc gtttgttgtt gtaataatta atatagtctg
     7381 caattgcttg ttccaaatgc tcaattgact taaacgtctt ctcataacca taaaacatct
     7441 cagacttaag aatgccaaag aaggattcca tcatgccgtt gtctggacta ttgcctttac
     7501 gtgacatgga tggttggatt cctttctcct ctaaaaaatg atgatagaaa tcatgttgat
     7561 attgccatcc ctggtcacta tggagaattg tatttttgta atgtttctct gtaaaggctt
     7621 gttctaacat agctttcact tgtatcaagt tcggtgactt agaaagattg taggcgataa
     7681 tttcactatt gaagccatct aaaattggcg acaaatagag tttttggctg cttgctggaa
     7741 tggcaaattc tgttacatct gtgtagcatt tttccaatgg tttggatgct tcgaactggc
     7801 gttggatgag attctctgct ttcataccaa cctctccttg atatgaagaa tacttacgtt
     7861 tacggcgaat tctagcggtt aaaccaagta ctttcataag acgttgaact ctcttatgat
     7921 taatcacaat tcctcgattt ctcaattcaa gagtcattcg acgatagccg taatttcctt
     7981 tatgctcagt aaaaatggct tgaatttcag ctttaatgtc ataatcctta tcattttgat
     8041 ccagctgttt taagtggtaa taataggttg aacgagcaag cttaataatc tttagaagca
     8101 tatctaaaga aaactcagtt accaatcctc ggacaatttc cgtttttctt cttgctcttt
     8161 ttcttccctc aatcggagtt ctctcaactt tttaagaact gcattctccg ctctaaggta
     8221 ctcattttct gcttgaagac gttccatttc ttccagtttt ttctttggct tacgtcccat
     8281 tttagataac cttcctcttg ttttctcaac aatagtatac ccgtttttct tatagtgtgc
     8341 gagccagtta ggaagcgtcc cacgatttgg gagagcatat tcaagagaaa ctctatcttg
     8401 agaatagcct ttatatagga ctttatcaat catttcttgt tttaattcag gagagtagta
     8461 acgattcttt ccttttttag cgatttctat tccgtatcga tcaatcaatt taatcatgta
     8521 gctaagatta gaaatgttta tcccaaattt atttgaaagc tgatctaagc tatatccttg
     8581 gtttctaagt tcatagattt gaaccttatc ttcataagtc aatttcataa taaaaacacc
     8641 ccgaaagtta gattttttct gtctaacttt tggggtgcag ttcataaaac cgttgctttt
     8701 tgcatgattg tgatagactt ggtgaaatag aattgaccaa aaatcttctg aaatataaca
     8761 agagagtgac tcgaatttaa aaagctagag ttccacaatt ggaaatctct agcttttttg
     8821 tgactgagaa ctttttgtcc cagcctctac tttctactga ctactatcct gcatgcccta
     8881 agtcgagata gagaatatct cgcttagtgg catactctag cgcatgttca acagcctcaa
     8941 ataaatctga agctagaaac cttttcgtaa agacggtttc gtctttacgc ttaaatttcg
     9001 caacataact atgtttagtc attttttctc cttctaatat tcatattgtc ctttaacacc
     9061 actatagatc cagtaaactg ctttatcata aacttgttta aaggagatac ctaatcgatt
     9121 ggctacatca agaattgaaa tttgcttaca ttcctctata ttcataaaat atcatcattt
     9181 tgtcgtagta ttcggcaatg atggaacaga tgaggattct tctaaagttt taggagttgc
     9241 cttatctaga tcatctaacc cagatttcca aacctgtact tggttgacca ataacttacc
     9301 aggtagtttc gaatagttca aattaaccgt tctggtttct gtttggtttg tctttgattg
     9361 gttggcattc tttaaatcag atacataagt tacattataa gagaccatgg caatggcttg
     9421 attcgtagtc tgattgacaa agatatctgc tttttcaaaa tgataatcca aaatatagtc
     9481 cttatacact tggttcatgg catcattttg acttgtcaat tcttgagaat aggccgattc
     9541 agtcatataa ggttgaatac gtgtattact ttcccctagt ttttctttcg tatagtactg
     9601 tgtcaaaaat tcttttacag tatctgatga taaaatactt gctttatctt ctgcttgttt
     9661 gtcctctaca agtttagctg cagccaattc gatttctttt cgactttgtt tggcagtaga
     9721 atgttgacca atagaattag cagtaagttg tggtgttgat gaggtggata tactaaaaaa
     9781 tgaggaggaa attgataatt acttcaccta gctaaaagtt caacgaatta gggagacatt
     9841 aggtagcctc atattacttt gattagtttt tgctataaca ttgtcaaata tgatgacaaa
     9901 aaaatccgtc cgcacttttt tacgagtagg acgaattaaa tatgttatac aaaccatcag
     9961 ctttttaaca attctacata aggtagttgt tgatgcaact accttttttc tatgctgatt
    10021 agaacaaatt tgacatggct acaactgcga ttatctgata tagagtatta tataaactga
    10081 ttcctcctac cccttatcca caattttaat acggctactg ccatcgtgcg acttgatgat
    10141 aactagttgc tgagcaatac cttctttcat atcgtctacg tggctgatga caccgaccat
    10201 gcggttttca ccgatttgtt ccagaacaga aatggccttg gtcagggctt ccttatccag
    10261 tgagccaaac ccttcatcga tgaagagagc ttcaacaacg gcacccttgc tggtattttg
    10321 gacaacttct gagagggata gggcaatggc cagtgcagcg ataaaggttt caccaccaga
    10381 caaggattta acggagcgtt cactacctgt cagctggtca tagacgttga tatccaaacc
    10441 gaagtgatca cgcgccctgc gtccttcctc acttagaaca aaggaatagt ggttatccgt
    10501 taatagtccg atgtagttag cattggcata gtccaagatt tgttggaaat actgacggat
    10561 aacgtagacc tcaagattaa gacgaccagt tagagcagta ttttctccct taaccacctt
    10621 aaccaaatca ctgagttctt ggtgggcctt aaaggcctct tggttactgt cttgaagggt
    10681 tttagccgct tggtaggtag ccgtcgcatc cttaagtccc ttttccatga cagaaaactg
    10741 agcgagctgc ctatcataga tttcctgaca attctgtact gcttgcgcta gactatcgag
    10801 atctggttgt tcttgatttt ggagaagctc ttgcccctta tgaatctgcg cctgtaattc
    10861 ttgtttgagc gttgcatagg tcgttaattt ggcctgaagc ataggaatag cttgattatt
    10921 tacctcaata agccagagtt cgacctgctc taagtcatta gcgagggctc cttcagcctt
    10981 gagactttgc tctaattcag cagataatcg cttaacatct tgatttacct tatctttaga
    11041 cttagttata ctctcaatct gcccctttat tcctttaatg tcggcatgaa gttggttgta
    11101 ggcttcgcta ttttccttga cttgcttatt gtagaggttc agctcctgat gagcaaggga
    11161 aatccgttct tgatatacct caacagactc aagttctgga tgagcttcct gcaggtcctc
    11221 taggcgttct tgagcttggt caagcactgc cttggcctct tgataggttt tagccaaatc
    11281 tgtcgctttt ttttgagcct tacctagctc atcttgatat cggatataat ctgtctcttc
    11341 cttatcataa cgtttttgta actcttgata atactgctca accttcagga gtagggcttg
    11401 cccacggtca gtttcatagt ctatcgaaaa atcaaaatca aaccgtccct taacgtgctc
    11461 ttctaattct tgatagtgct tttcaagagt tgccttgact ttagccactt ggtcaagcaa
    11521 atcctgacgt ttagatgcaa cttcactcaa ggtagcctga cgatttgata aagtagcgac
    11581 ttgcttttct ttttgagctt gaagcttctc cacctgatcc atgagatttt tcaaggccac
    11641 ttcatcagcc tgtgctccac caacattagg gtgttccaga gcaccacaaa ccatacaagg
    11701 atgcccctcc tctaactctg cctgcagttg gacaataatg agttgacggc gtgaaaccaa
    11761 agtccttctt aactcctctt ccaattcttt gagaatttct tgagcttgat caatatcaaa
    11821 agataacgtt tgatgacgtt tttcggtctt tgtcaactcc tgattcaagt tctctatttc
    11881 tttcaggtcc tgagcaagtt gattctccac actgtagccc acaatctgga agagtttttc
    11941 ggcctcatgt aaactatcta aactaagacg attagcctcc aagtcagaca aggacttgtt
    12001 aagcatctca acctcttttc tagcctgctg ataggtctct tccaactgct tgtagttagt
    12061 cgttgaacgt ttgattttct cctgttcttg ggcaagactc tgggcataga taatattctc
    12121 tttccaagtt tcaagctcct cttctttttg aagaaaatcc ttagattgaa ctgtgagttc
    12181 ctctttttta gccttaacat cctcaaacgc ctgttgcttt tcacttaagg cttcttgagc
    12241 aatttcaagg tcctgctcta attgcatcaa ctgtttccga tactgcttca aggtccgaat
    12301 ggtttcctgc agaccttgag caaactgtaa ttcctccaga tgcacttttg cctctgcctg
    12361 tccttgagcc ccctcctcaa tttccagacg gtaacgttcc ttggcttgct ccaattcttg
    12421 aaaaatcttt gccaaatctt gggcagtttg caagctcttc tgcagttgtg ccaaatcctc
    12481 gtgggcagcc ttcaagatac ttttttgctt cgtaacattt tcttgacgct gagacaaaaa
    12541 ctcttcaaga cgtgtcaatt tttcagaggc tggcgtttgc tccaagacgg ataattcttc
    12601 ctcagaccaa acctgactgg caaaatgacc atctagctga gcctgacgct tttccatatc
    12661 cttattactc tgacgaagac gctcttccaa gctcttttga aaatggtcaa aaatacccgt
    12721 tccaaagatt ttctttaaaa tttgagtctt ggtcttagaa tcttctttca agaaacggct
    12781 gaaatcattt tgtggaagga gaataatctg tttgaactgc tcagcattga gccccaaaat
    12841 ctgctcaatc tggtcactca cttccttgat cttatcccca agcttttcaa tttcctgacc
    12901 accaatctta tccacaatga ctagagaagc cgtcgccttt tgcatggtag tgcccccacc
    12961 ctgcttggcc ctctcttgct ggagaactcg gtcaatgcga taaaggtgat tgccttgttg
    13021 gaaatagaaa gtcaccttgg tcaaatcatc ctctggacca gcgaaagttg accgcatctc
    13081 ctcaacatta cgatcaccac tggtcgtagc aaacaaggct accgtcatgg catcaaagag
    13141 agtactctta ccagcccctg tatcccctcc aatcaaaaag aggggagcat ggtcaaactg
    13201 agtgaaatta ataacttcct tacgatatgg tccaaaattg gtcaattcta actggactgg
    13261 tctcattgtc gactcctctc aatctcctca aaaacacttt ccacaagggc agtctgtctc
    13321 tcagataaga catcgccccc agttactgtc tggtaaaaat caaatacgat ttcctggggc
    13381 gactgcattt ccaaatcttt taagtgctga tcaacggtca agttttcttc cctaacatca
    13441 cccagacgac tgaaagtaat ttctacaatg tctgtcccat aaatctcttc cagtcgggca
    13501 cgcacattga taccctctaa ttccttacga ctagacagtt gaatatcaaa ggcgaaccag
    13561 gctttttgac aaggttgatt cttataaaat tcaggtgaca tcaaggtttc aaaagattcc
    13621 tgtaaaacca caatcggccg tttaacctct agagtatgga aggtctgaga catatcacca
    13681 gacgcatcca attcaagaat atagacaccc ttttcttcct tacgcttggc ttctttgaca
    13741 ttaaaagcga ctggactgcc tgaatattgc acgcgcttgg taggactagc aaaacgcgta
    13801 tggatatgcc ctaaggcaac ataatcgaaa gacttgaaaa ggtcactggt cacattggta
    13861 agaccaccta ccgtattact ggtttcagac aacatcaatt ctcgaagacc ctgaccatcg
    13921 ctatcatcct tcttagaaac cgcaaaatgc gtcaccaaga catgagcttt gtcaggatca
    13981 aaagcttttt ctatatcctc aagaatgtag gtcaaggcat caccaatccc ctgaatttcc
    14041 tttccctcat catccttata gtaaatacga gcatcaatag gatcgataaa aggcagcaga
    14101 aaaatctggc aattctccaa ctcaataggc tcaaaagcct cctccaaacg tgtacttaaa
    14161 tgaaggccct gatgttgaaa gaagtcacgc ccaaaatgta aacgttcagc cccatcgtga
    14221 ttaccactaa tcgcatagac aggaatctgc tcctccagta ccaagcgggt caaggtctta
    14281 ttaaaaagct taatcgcatc cacagggggc accgcacggt catagaggtc cccagaaatg
    14341 ataaccccat ccactttttc gctaatagcc aaatccacaa tttgttgaaa agcccactcc
    14401 tgctcctcca acaaagacca gccattgagg gttcgtccta catgccaatc tgacgtatgt
    14461 aaaaacttca tgacaacctc ctcattcatt ttgtcttact tctattgtac cttatcaagc
    14521 taaatactgc ttaaaagttt cacaggtttt gatagtttta ccgtttttta gctgtaaaga
    14581 tcaaaaaatc tctcccaagc tatcctgtac tgaccccaaa aagttagaca atttatgtaa
    14641 gcaaaggatt tggctctgta ttgcacagga ttgagtcctt ttagttttac cttaatgcat
    14701 ttgttgttgt agtaatcaat atagtctaga ttaccctgcc tcaattggtt aagtaattta
    14761 aatacctcta accaagaaaa tcaatattat ctattctttt aattgacttt tatagattct
    14821 aagcattatc atataggttg gtactagtgc acatcttgta ttttaggcaa taatatttac
    14881 tcacttttcg ttattgtcag taccgatcct ttttaaattt ttcactatga aaacctaaaa
    14941 ataatccgaa ccctaagggc tcctgacttt ttactttatt ctaggctttt tttatccgta
    15001 gcttgttagc tgacttggaa ctaggcatgt agtatttact atttccctac ttgagatttt
    15061 ttataagtca catgcattat tccatctgaa cgaatggtat gatttttatt tcttttagag
    15121 aaacaccggt aatagctaat tcctatctta aatcacttga aatatattta taatgtgttg
    15181 gagtgctaat cagtaccgct tgtagatttt tggaagatac taacacacta atgatttaat
    15241 cccctttaaa acatgaaaag agaagcctcc aaagcttctc ttttataatt atcaaataat
    15301 gtacaactag attcttaata actacctaat ttagtggttc aatcatgaag cttaattgat
    15361 agctatctgc tgagctaagc aagaattcgt catgaactgg agcaccccat gagtcgtcac
    15421 caccgacacc catttgagca gcaagaactt taatccatgt agcatcagat tcttgcaact
    15481 catattggtg acgagcattt tcaatttgtt cagtactgtt acgcaaagca ctgaattcga
    15541 atgctttatt aagtgcggtg aatttaagac cattatggtt atcatcagat actgtgaatt
    15601 cacgagtacc atagtgatta ccagattctt gtggcattag atatggagca aatgtctttt
    15661 caacagatgt ttcatatcga ccaagatagg caccaggaag tttatcacgg tagctttctt
    15721 ctgcaccgta tccataatag ctaaggtttg taaattgtga accgatagca aattctagac
    15781 caaattcagg gaagtttggc aaacctgctt taccatcata gtttgcagta acaaagattc
    15841 gacccttgta gtcaacttga taagttacct taacttcgac atcagacaag cctggcaatt
    15901 catgaacata agtcacttta acagagtcgt cttcgatttg aatttgagta tctgtaactt
    15961 tactatagtt tccagcaacc ttccagcctg ccatttcgaa tggatatcca gcaccacgat
    16021 cgttgtcagt gtaagcacga gtgaagctaa gtttaggacc tttctcaatg aattcaacac
    16081 cattatactt agcagatact aaagtatttt gtgcacgtga aagcaagatt gagaagtttt
    16141 gtccttgaat accgatgttg aagtcgcctt caacaacatt caaaggtgct ttaactggtg
    16201 tttcagtgct aatcttttca acaacatatt gaccacgaac aatttcatga cctttaggag
    16261 cccatttagt tgcttccctc agaacacaag caacttcgta aatttgttca gaatttgaag
    16321 cctcgactac aaagttaact gggaatgttg cttcttcgcc tggtttaaca tcaaagtgat
    16381 attcactttc actaactttt ctaccatctt cgtaaactct agctaggaaa gtataagcag
    16441 aaagatcttc gaagagatta tcattcttga tagttactga tttttcatca acagcaatct
    16501 taatattaga gtaaagatgt ttaactgttt gaagttttgg agttagggta cgatctgcaa
    16561 agacgatacc atttccacaa aattcgtagt cagaaggtct atcatgccag tcaccaccat
    16621 atgataggaa ttcgctacca tttggaagtg ttttgtaaat agcttggtca atgaagtccc
    16681 aaataaatcc accttggtat tctggatatt tctctaagtc agtgtagagt tgcaatccac
    16741 caccagagtt acccattgtg tgcatgtatt cacatgaaat ataaggtttt tgaggtttgt
    16801 tagttaggtt acctgaagca aagtgtttat cactaacgct tgaaagatca actagtttac
    16861 cagttgtgag gtattcttcg atatcagctg gtttcgcata catacgactt tcgatgtctg
    16921 taatgtaatc aaactcacga caccatgcaa caccttcata gtgaactgga cgagtattgt
    16981 caacactacg gaagtaatca gccatgtcag caatatcttt accagcatat gattcattac
    17041 cacaagacc
//
