LOCUS       gnlProkkaCNGBMCEL_68   13585 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CNGBMCEL_68.
ACCESSION   gnlProkkaCNGBMCEL_68
VERSION     gnlProkkaCNGBMCEL_68
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 13:55:36
            Original ID  :: gnl|Prokka|CNGBMCEL_68
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13585
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..153
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_1"
                     /sec_met_domain="L_biotic_A (E-value: 1.7e-27, bitscore:
                     86.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.1e-07, bitscore:
                     23.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKETTIIESIQEVSLEELDQIIGAGKNGVFKTISHECHLNTWAFL
                     ATCCS"
     CDS_motif       1..72
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKETTIIESIQEVSLEELDQIIGA"
                     /locus_tag="ctg52_1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       73..153
                     /prepeptide="core"
                     /locus_tag="ctg52_1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2778.2"
                     /monoisotopic_mass="2776.3"
                     /core_sequence="GKNGVFKTISHECHLNTWAFLATCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKETTIIESIQEVSLEELDQIIGA"
                     /leader_location="[0:72](+)"
                     /alternative_weights="2796.2"
                     /alternative_weights="2814.2"
     protocluster    1..13585
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[798:3585]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      799..3585
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..13585
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13585
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             618..779
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_2"
                     /sec_met_domain="L_biotic_A (E-value: 5.9e-26, bitscore:
                     81.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNNNKICQDALESLQELKLEEVDELLGGAGHGVNTISAECRWNS
                     LQAIFSCC"
     CDS_motif       618..704
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKNNNKICQDALESLQELKLEEVDELLGG"
                     /locus_tag="ctg52_2_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       705..779
                     /prepeptide="core"
                     /locus_tag="ctg52_2_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.40"
                     /molecular_weight="2495.8"
                     /monoisotopic_mass="2494.2"
                     /core_sequence="AGHGVNTISAECRWNSLQAIFSCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNNNKICQDALESLQELKLEEVDELLGG"
                     /leader_location="[617:704](+)"
                     /alternative_weights="2513.8"
     CDS             799..3585
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     689.1; E-value: 1.7e-208)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_3"
                     /sec_met_domain="DUF4135 (E-value: 4e-82, bitscore: 267.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.7e-54, bitscore:
                     175.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQKEQLYSQFDKFPKVVIERLIPEVLNESDSLIKQIEEKISDYY
                     RSTLIYLINEKRINGTLVGETAELRYDFFNNVLCRNGTILDEIEERFPKINQRVFISIK
                     HYLDLLNCVKKHFVSDFLELKKLKFLKSNDESPDLNVLDIKVTGDIHNGSGVCILDYNR
                     QKLVYKKKSSRPNILLKELDSQASNYLKKEIRFIPDFLDKNEYFWEVFVESKPVSSLKE
                     ANEFYKRMGYLLVYSYILNISDLHFENLISHSIQPILVDAETVFSTNPYETVAENDATL
                     KIVENSRNSVLSTGLLPISEADKIFGGDTSGVLGGTLIGEAKVIINHNRDDIHVEKQKY
                     KTENQNHLPYFENNLGIKTYLNAEEYVEYIKEGFIELSKFIINNKEALKKLYLSFSDIK
                     TRVLFRNTRDYSLVRQLLLSPVYCNQDNILFEKMSNKLTNYDSHNLCQSEVKQLLNMDI
                     PYFYVCASDINVKDKDGNTNIWKLKKSSLSDTIEKLEKFDLDTMEEQLDLVEFSIKTPN
                     ALYSTELQESYKIFQNSNSNHSILFTGINTIVDTILKNEKFSKLDGSTNWLTLKVTDYD
                     AFQLEPMDSSIYEGIAGLSIALCEVYELVDDDRQQRIYNCLRRIFMTLMKAYYSTQNQS
                     YYVGKIGILSAMIRIQSITGQEIPVSIFDINNKYILDLNVQSADFLSSFPSEIVALRNS
                     NVSIGNLQQSFEKLVDLKIISEDYIAWDKLESNNVSLAHGNLGIELGLLYLAVALNSSE
                     AVELFYQATNFDSHQKLSNGWIDKRNNSTSANWCHGSTGVLAARLAQLQLDKKFHIISK
                     TKRSELEADMKHAASQIIEIGFDMTNFSICHGTSGNLLALSYYCSYLSGNEREELEKIL
                     DIEYRKLHSFGLENGWMCSFNTKYNVYGIMNGLSGILYSTAKYLKKDDSLDILIPTL"
     CDS             3612..5684
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 128.8; E-value:
                     4.3e-39)"
                     /gene_kind="transport"
                     /locus_tag="ctg52_4"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.4e-38, bitscore:
                     123.0, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNEEDCLLACYTMLLNDLGHKVPLYEVYDKDSLPADGLN
                     VSYLLSLNKRFGVALKAYHASFRDLLQVYNEKKQRIILHWNQDHFVVLDKITEKQVTIV
                     DPAIGRVKYSHDEFLNHYSETIVLINKDENFQTQKYKQIFWKYFKLTLKTKTIILFLLS
                     LVLIQISVLAFSILLRYMLSEKFQFLSNILVLFGVVLFQLLGYFIKNSALNEYNLDFDD
                     NYSKALFQKLLKKPLLYFRNHLSGGISEKINFKSTLRDNVTLKIIPSCVSFISAIVIFT
                     YLITISVRLTIILIIIILVYSVISIILYRKQNEYNQTYLQYLIDFNSELQTDLDDIDYI
                     KIMRREGLTFASWMKINQQVTEKYSQILKFENLSQLVSTIFNYISLSVIIVIATYYNKY
                     IKVSISDLLVYQTSISLLISAIEQVKGAVFEVVKLGIYAEKQSDLLKDSRPILVQSSDS
                     DEYLIKAESLNFSYGMSPIYKDINLTINRGEKIAIIGKSGSGKSTLLLLLAGMLRFSGS
                     LKYGIKNFEDSLSVVLQNMTLRKGSVLENLEWDTDNLEPLYQVLKDTSADEVIAQLPNK
                     IHSKLLKQGKNLSGGQIQKMLIAKSLLKKNSIIFWDEAFSNLDEQSKNRIYLNILQNSQ
                     YSERTMLIVSHHLDIVDYVDYVIYIDNEMGDVYKDTHINLMESNENYRNFINSKI"
     CDS             5788..6699
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 173.8; E-value:
                     7.9e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg52_5"
                     /transl_table=11
                     /translation="MMNNIIELKKVKKVYKDITTVDIEKITVREGEIYGFLGPNGAGKT
                     TTMKMILSLVDPTSGEIFVNKKDIRKDKNYLSQIGSMIEEPSYYPNLTGYENLLVFQKM
                     VGFDENNIWPTLELVGLADEKNRKKLVKAYSLGMKQRLSLAFALVKKPKILLLDEPTNG
                     LDPAGIHEIRELIVELAKEKGLTVFISSHILPEIEHIADRVGIINHGRLVYEGEIEAIK
                     SNTWIEIGGDFSQSNIVHTLVELGTVEILGASTSHVKLSNIDNNQLANVVSYLTENGYR
                     IFRVVRESETLEDIFLSLTKEA"
     CDS             6701..7465
                     /locus_tag="ctg52_6"
                     /transl_table=11
                     /translation="MIKVLQIELLKSKRTKSFMISFLMMFVAVTWSLLAASRSIGVPKL
                     RTIGLFFNNLQATPIFLPIAISLFVSRIVSNEKEGNTFKLQEANNINLITIFKRKLIFT
                     NTIFLLLNVVQVLIVYLYAVRYGIDVAVSNLLLQVVGLTMASFTLITFFLFLSMILEKH
                     GMVLGIGFVSGFLGMVLSEASKWLNLIFPFGGSSFLALYRIKVLHSGDKLDYIFVWDKS
                     VPLNYLIYLFYCIFVYFIIKYLLVKKKEENYD"
     CDS             7528..8265
                     /locus_tag="ctg52_7"
                     /transl_table=11
                     /translation="MIDYFKAEWIKNRKVVILAIGLIFLALSSFIGLANFFLNYDVLIE
                     EQMSRVLWGQLTFYNGQLLFPAMLAIFSGLIILPEFERKTLEMLRANQASVKKMVLSKF
                     LLALFLVSVVQAVLFAIYLLTLYLSQIPFQIEDLLLFLRATILSVIGSSSVLMIHSYLM
                     AKTRNFAKSVGVAAIGSFSGFIFIMLGGFINQLFPYSQPMIGLRSRALNDMSFLEFMLF
                     ITVNSLYSFIFYWLTVKKLENNE"
     CDS             8545..8769
                     /locus_tag="ctg52_8"
                     /transl_table=11
                     /translation="MYQRIRDLREDHDFTQRFVANLLSFSHTNYAKIERGEVALTADVL
                     VQLSKLYNVSTDYLLGLTDYPDRIKHKIK"
     CDS             8810..8917
                     /gene="allorf_08810_08917"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_08810_08917"
                     /protein_id="allorf_08810_08917"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGLSYLSSNLVRYAVIGAKIISYKIEWFSICHNHK"
     CDS_motif       8810..8863
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MGLSYLSSNLVRYAVIGA"
                     /locus_tag="allorf_08810_08917_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8864..8917
                     /prepeptide="core"
                     /locus_tag="allorf_08810_08917_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="2110.5"
                     /monoisotopic_mass="2109.1"
                     /core_sequence="KIISYKIEWFSICHNHK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGLSYLSSNLVRYAVIGA"
                     /leader_location="[8809:8863](+)"
                     /alternative_weights="2128.5"
     CDS             9229..11022
                     /locus_tag="ctg52_9"
                     /transl_table=11
                     /translation="MKKNNVEIIKADSLVRRRGVNVERHLKRVAAYCRVSSDSDDQKNS
                     YESQVRHYKDYISQRSDWELVDIYADEGISGTQVGKRQDFQRLINDCVNGEIDYIVTKA
                     IARFARNTLDTLKYVRMLKDMQIGVYFEEENIDTLTMDGELLLTILSSVAQQEVENTSA
                     HVKKGLKMKMQRGELIGFQGCLGYDYDVETKQLSINTKEAKIVRYIFERYLEGIGGKVI
                     ARELDELGYKSPRGLDHWNDTTVLGIIKNEKYKGDILMGKTFTVDPISKRRLSNLGEED
                     KYYIKDNHEPIVSKEDFEKAQAIRLRRAGNKKTAANVNGKRERYSKMYAFSSMLECGFC
                     GSLLSRRSWHCRSDYRKVVWHCVTSIKKGKKYCKHSKGLEELAIEGAFMEAYRQLYHSN
                     ENLMTDLLETIESELNDNSLNKELKRITNKLRTLLKKEENLVNLKLEGKISDTIYNEKY
                     NEISSEKVFLAEEKVNIETTLKSEIDVKKRLTEFKHLLSSQKMLTEFDRAVFESIVEKI
                     IVGGVNSDGEIDPAMLTIIFKTGETQNKDGNQFKSKRKNAKLETDKLCPQNSDEDKKMY
                     SQGPDNTHRVCRSAHSCGTVI"
     CDS             11296..11583
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MLVSMNRSDLPYLKEQDFASHTAIYVLIGGNKRYVGNLQAKPFIN
                     GYINTFLKKIRNGLSQFYFSPEQMENYQKLIPIIWRSDSFKISLRNQITK"
     CDS             11583..12056
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MNSTIGNKSYIGKLSKAQSDQLYETVFEIIDDIANIDLFGVSEGE
                     LTNEVSPSDMFEIQYDGHTLQSKSARGLFVDFVKSMLVDDKYKQQIEELIAPNAPTAGV
                     VLGRKVSTYNGRPISAEVAPGVWLFTNFSRKDTKNKLEKLTKQLGISAKINWK"
     CDS             12224..12445
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_12"
                     /transl_table=11
                     /translation="MGFSYERLWELTLKRRINKTSLRDMAGITNSTLSRLSKDETVSME
                     ALARLCEALQCQLEEIIEYKLENKDRVE"
     CDS_motif       12224..12307
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MGFSYERLWELTLKRRINKTSLRDMAGI"
                     /locus_tag="ctg52_12_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12308..12445
                     /prepeptide="core"
                     /locus_tag="ctg52_12_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.80"
                     /molecular_weight="5074.7"
                     /monoisotopic_mass="5071.6"
                     /core_sequence="TNSTLSRLSKDETVSMEALARLCEALQCQLEEIIEYKLENKDR
                     VE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGFSYERLWELTLKRRINKTSLRDMAGI"
                     /leader_location="[12223:12307](+)"
                     /alternative_weights="5092.7"
                     /alternative_weights="5110.7"
                     /alternative_weights="5128.7"
                     /alternative_weights="5146.8"
                     /alternative_weights="5164.8"
     CDS             12442..12903
                     /locus_tag="ctg52_13"
                     /transl_table=11
                     /translation="MMCYLGNKTKLLTFIEKVIDKYKIEGETFADLFAGTGSIGDYFKG
                     KYTVYSNDYMYFSKVISEAKLSNFKTPDFKEFHKKYGVSPFEWLNKKQYKTEKSYFTYN
                     NYTPLADRMYFTEDNTLNIDGMRLDIEELFHEGYISKAEYSYLLASLLD"
     CDS             complement(13070..13327)
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MVEPLISISLLGYIISTDIAENLSRSQIQKQGMDMLDKFIRIQTT
                     DASIIDDIVDISTPSKFTKGKKLHERGDNEEHLPLDDDLI"
ORIGIN
        1 gaaaaagaaa caacaattat tgaatcaatt caagaagtta gtcttgaaga gcttgaccaa
       61 attatcggtg caggaaaaaa tggcgtattt aaaaccattt cgcacgaatg tcacctaaat
      121 acatgggcgt ttcttgccac atgttgttct tgattttgga tgactaagtg tctaatatgt
      181 tacattaaaa aaggagggaa acctcttttt tatattcaga aattttaatt cttaaagata
      241 atagaattgc ttatcgaaaa atagaatcta ggagtaaaga tttgtaaagt attttgtgtc
      301 aagacgagat tctacccact aaatattctc cgttgtattc actaaagttt acgatttaat
      361 gatgaaggat aaaatgtgat gtgtatttaa agaaagtata tgatttacaa cttatgtaaa
      421 aaatattaag aagaggtata aattagtaat gtgaagttac tttatccttg tttgattctg
      481 aactaacaag atttatcaat aaattaacat tagctttaga ttagctttaa cttttcttta
      541 tgttgcgatt ttaaaattaa agcataaata aaaatatttt cgagttatgc tcggtataac
      601 atatgaggtg ataaattatg aaaaataata ataaaatttg tcaagatgct ttggaatcct
      661 tacaagaact taagttagaa gaagttgatg aacttttagg tggagcaggc catggagtaa
      721 atactatttc agcagaatgt cgttggaata gtttacaagc aatcttttca tgttgctaat
      781 ttttagagag gtaatattat gaatcagaaa gagcaactat atagtcagtt tgataaattt
      841 cctaaagtag taattgaaag gctcatccct gaagttttaa atgaaagtga ctcgctaatt
      901 aagcaaattg aggaaaaaat ttcagattat tatagatcta cattgattta tttaattaat
      961 gaaaagcgca ttaatgggac attggttggt gaaacagcag aacttcgata tgactttttt
     1021 aataatgtat tatgtagaaa cggtactatt ttagatgaaa tagaggaacg atttcctaag
     1081 attaatcagc gtgtatttat cagtattaaa cactatttag acttactaaa ttgcgtgaaa
     1141 aagcactttg tgagtgattt cttagaatta aaaaaattaa aatttttaaa gtctaatgat
     1201 gagagtcctg atttaaatgt tttagatata aaagtcacag gagatattca caatggaagc
     1261 ggagtctgta ttctagatta taatagacaa aaattggttt ataagaaaaa atcatcaaga
     1321 ccaaatattc ttttaaaaga attagatagt caagcaagta attatttgaa aaaggaaatt
     1381 aggttcattc ctgatttttt agataaaaat gaatattttt gggaagtatt tgtcgagagt
     1441 aagccagtat cctcacttaa agaagcaaac gagttttata agagaatggg gtatctttta
     1501 gtttactcct atattcttaa tatctctgat ttacactttg aaaatcttat atctcatagt
     1561 atccaaccta tattagtaga tgctgaaact gttttttcaa ctaatccata tgagacagta
     1621 gctgaaaatg atgcaacatt aaaaattgtt gaaaatagtc ggaattcagt tctttctacg
     1681 ggattattac ctatttctga ggctgacaaa attttcggag gtgatacgag tggtgtttta
     1741 ggaggaacgc ttattggtga agcaaaagtt attataaatc ataatagaga tgatatacat
     1801 gttgaaaaac agaagtacaa gactgaaaac cagaatcact taccatactt tgagaataat
     1861 ttgggaataa aaacgtattt aaacgctgaa gaatatgtag aatatattaa agaaggcttc
     1921 atagaattaa gtaaatttat tattaataat aaggaagcat tgaagaaact ttacttaagt
     1981 tttagtgata taaaaacacg tgttttattt agaaatacta gagattatag tctagttaga
     2041 caattattgc tttcaccagt ttactgcaac caggataata ttttgtttga aaaaatgtca
     2101 aataaattaa cgaactacga tagtcataat ttatgtcaat ctgaagtaaa acaacttttg
     2161 aacatggata ttccgtattt ttacgtttgt gcaagtgata ttaatgttaa agataaggac
     2221 ggtaatacta atatttggaa actaaaaaaa tcttcactga gtgatacaat tgaaaaattg
     2281 gaaaaatttg atttagatac tatggaagaa cagttagatt tagtagaatt ttcaattaaa
     2341 accccaaatg ctttatacag tacagagttg caagagtcat ataaaatttt tcaaaattca
     2401 aactcaaatc atagcatatt atttactggt attaatacta tagttgatac aattttaaaa
     2461 aatgaaaaat tttctaaatt agatggaagt acaaattggt taactttgaa agttacagac
     2521 tatgatgcat ttcaactaga acccatggat tcatcaattt atgagggtat tgcaggactg
     2581 tctattgcgt tatgtgaagt ttatgaattg gtcgatgatg atagacaaca gagaatttat
     2641 aactgtttac gcagaatttt catgacttta atgaaggctt attattctac acaaaatcaa
     2701 tcgtattatg ttggcaagat aggaatttta tctgcaatga ttagaataca gtcaattact
     2761 ggtcaagaaa taccagtatc tatttttgat attaataaca aatatatctt agatttgaat
     2821 gttcagagtg cagattttct atcaagtttt cctagtgaga ttgtagcctt acgaaatagt
     2881 aatgtatcaa ttggaaatct tcaacaatct tttgagaaat tagttgattt gaaaattatt
     2941 tctgaagatt atattgcgtg ggataaattg gaatctaata atgttagttt agcacatggg
     3001 aatttaggaa tagaactggg attactttat cttgcggtgg cattgaatag ttctgaagca
     3061 gtggaattgt tctatcaagc tacaaatttt gatagtcatc aaaaattatc aaatggatgg
     3121 atagataaaa gaaataattc gactagtgct aattggtgtc atggttctac aggggtgtta
     3181 gctgcaagat tagctcaatt acagctggat aaaaaattcc atattatatc taaaacaaag
     3241 agaagcgaat tagaggctga tatgaaacat gcagcatctc agataattga aattggtttc
     3301 gatatgacaa atttttctat ttgtcatgga acaagtggaa atttgttagc acttagttat
     3361 tattgctcgt atctatcagg aaatgaaaga gaagaattgg aaaaaatttt agatatagag
     3421 tatagaaaat tacattcatt tggtttagag aatggatgga tgtgcagctt taatactaaa
     3481 tataatgttt atggaataat gaatggtttg tcaggaattt tatattctac agcaaaatat
     3541 ttaaaaaaag atgattcgtt ggatatttta atccctactc tttaaaaaga gatagaaagg
     3601 aaaactcaag tatgaagatt attttacaaa acaacgaaga ggattgtctg ttagcgtgtt
     3661 acacaatgtt attaaatgat ttaggtcata aagttccact atatgaagta tacgataaag
     3721 actcattacc agcagacgga cttaatgtat catacttgct atctctaaac aaaagatttg
     3781 gagtagcttt gaaggcgtat cacgcgtcgt ttagagattt attacaagtc tacaatgaaa
     3841 aaaagcaaag aataattctt cactggaatc aagatcattt cgtagtatta gataaaatta
     3901 ctgaaaaaca agttacgatt gtagatcccg ctattggtcg tgtaaaatac agtcatgatg
     3961 agtttctaaa ccactattct gaaactatag tgttaataaa taaggatgaa aattttcaaa
     4021 ctcaaaaata caaacagata ttttggaaat attttaaact tactttgaaa acaaaaacaa
     4081 ttattctatt tttgctttcg ttggtactaa tccagataag cgttttagca ttttctatct
     4141 tattaagata tatgttatca gaaaagtttc aattcttgtc aaacatacta gttctatttg
     4201 gtgttgttct ttttcaacta ttaggctatt ttattaagaa tagtgcctta aatgaatata
     4261 acttagattt tgatgataac tatagtaaag cacttttcca aaaattgtta aaaaaaccac
     4321 tattatattt tagaaatcat ttaagtggcg gtatttcaga gaagataaat ttcaagtcta
     4381 ctttaaggga taatgtgaca ttgaagatta tcccctcttg tgtaagtttc atctcagcaa
     4441 ttgttatttt tacatattta ataacaattt ctgtaaggtt aacaataatc ttgatcataa
     4501 taattttggt ttacagtgta atttctatta tactttatcg taaacagaat gaatataacc
     4561 aaacttatct gcaatatttg attgacttta attcagagtt acaaacagat ttagatgata
     4621 ttgattatat caaaataatg agacgagaag gtctaacttt tgcatcgtgg atgaaaatta
     4681 atcaacaagt tactgaaaaa tattcacaga ttttaaagtt tgaaaactta tcacagttag
     4741 ttagcacgat ttttaattac attagtttgt ctgtaattat agttatagcg acttactata
     4801 ataaatatat taaagtatcc atctcggatt tactagtcta tcaaacaagt atttcattat
     4861 taatatctgc aattgaacaa gtgaagggtg cagtttttga agtagtaaag ttggggatat
     4921 atgctgaaaa acaaagtgat ttattaaaag atagtagacc aattttagta caaagttcag
     4981 attcggatga gtatttaatt aaggctgaaa gcctaaattt ttcttatggc atgagtccga
     5041 tttataagga tattaacttg acaattaata gaggtgaaaa gattgcaatc ataggtaaat
     5101 caggtagtgg aaaatcaacg ttactattac ttttagcggg tatgctacga tttagtggat
     5161 cgttgaaata tggtattaaa aattttgaag atagtttgag tgttgttcta cagaatatga
     5221 cattaagaaa aggaagcgtg ttagaaaatt tagaatggga tacagataat ttagagccat
     5281 tgtatcaagt attaaaagat acttcagctg atgaggttat tgcccagtta ccaaataaaa
     5341 ttcattcaaa gttattgaaa caggggaaaa atttatctgg aggacagatt caaaaaatgt
     5401 taattgctaa gtctttattg aaaaaaaact ctattatttt ctgggatgaa gctttcagta
     5461 atcttgatga acaaagtaaa aatagaatct atcttaatat tcttcagaac agtcaatact
     5521 ctgaaaggac aatgttgatt gttagtcatc atctagatat tgtcgactat gttgactatg
     5581 ttatttacat agataacgaa atgggtgatg tttataagga tacacatatt aatcttatgg
     5641 aaagtaacga aaactataga aattttatta attcaaaaat ttgagacttg cgttatacat
     5701 tcttaatgtt atctttaaga tgaacaggta caattattaa tgtaaagaaa ggagtagtct
     5761 aataaaatag attgctaaag gataatgatg atgaataata ttattgagct gaaaaaagta
     5821 aaaaaagttt acaaagatat tactactgta gatattgaaa aaattactgt acgggaggga
     5881 gaaatttatg gttttctagg gccaaacggt gctgggaaaa cgacaacgat gaaaatgatt
     5941 ctatcccttg tagatccgac ttcaggtgag atttttgtta ataaaaaaga cattcgaaaa
     6001 gacaaaaatt acctgagtca gattggatct atgatagaag agccttcata ttatcctaat
     6061 ttaacaggtt acgaaaattt attagtgttt caaaaaatgg tgggatttga tgaaaataat
     6121 atctggccaa cattagaact tgttggatta gctgatgaaa aaaatcgaaa aaaattagtt
     6181 aaggcctatt ctctaggtat gaaacaacgt ctttctttag cgtttgcatt agtaaaaaag
     6241 cctaaaatct tattattaga tgagcctact aatggtcttg atccagcagg tattcatgaa
     6301 attcgtgaat tgattgttga gttagccaaa gaaaaaggtc tgacagtctt tatttctagt
     6361 catattcttc cagaaattga acacattgca gatcgagtgg gtattatcaa tcatggtcgt
     6421 ctagtttatg aaggagaaat tgaagctatt aaatcaaata cctggattga gattggtggt
     6481 gatttttcac agagtaatat tgttcacact ttagttgaac tagggactgt agaaattttg
     6541 ggtgcatcca caagtcatgt aaaattaagt aatattgata ataatcaatt agctaatgtg
     6601 gtgagctatt tgacagaaaa cggataccgt attttccgag tggttagaga aagtgagacc
     6661 ctagaagata ttttcctttc gttaacgaag gaggcttaaa atgataaagg tattacaaat
     6721 cgaattattg aagagtaaac gaacaaaatc atttatgata tcgtttttga tgatgtttgt
     6781 agcagtaact tggtcattac tagcagcatc aagaagcata ggtgtaccaa agttaaggac
     6841 aattggatta tttttcaata atttacaagc tactcctatt tttttaccaa ttgcgattag
     6901 tctttttgta tcccgaattg ttagtaacga aaaagaagga aatacattta aactacaaga
     6961 agcgaataat ataaatctta taaccatttt caaacgaaag cttattttta cgaatactat
     7021 ttttctatta ttgaatgtag tacaagtatt gattgtatat ttatatgctg ttagatacgg
     7081 tatagatgtt gctgtttcaa atttactatt acaagttgta ggtttgacga tggctagttt
     7141 tactttaatt actttttttc tatttctatc tatgatatta gaaaaacatg gtatggtttt
     7201 aggaattgga tttgtatcag ggtttttagg gatggttcta tccgaagcat ctaaatggtt
     7261 aaatctaatc tttcctttcg ggggttcaag ttttcttgca ctttatcgca taaaagtttt
     7321 acattctgga gataaattag attacatatt tgtttgggac aagagtgtac cactcaacta
     7381 tcttatctat ctattttatt gtatatttgt ctattttatt attaagtacc tattggttaa
     7441 aaagaaggag gaaaactatg attgattatt ttaaagctga gtggattaag aatcgtaaag
     7501 tagtggttaa aaagaaggag gaaaactatg attgattatt ttaaagctga gtggattaag
     7561 aatcgtaaag tagttatttt agctattggt cttatttttc ttgctttgtc cagttttatt
     7621 ggattagcta attttttctt gaactacgat gtgttgattg aagaacagat gagtagggtt
     7681 ctttggggac agctgacttt ttataacggg cagttacttt ttccagctat gttagctata
     7741 ttctcaggtc taattatcct tcctgaattt gaacgaaaaa cacttgaaat gctacgagct
     7801 aatcaagcat cagttaagaa gatggtacta agtaagtttt tattagcttt gttcttggta
     7861 tctgtagttc aagcagtgct gtttgctatc tatttattaa ctctttatct tagtcaaatt
     7921 ccatttcaga tagaagattt attattattt ttgagagcta caatattatc agttattggt
     7981 tcaagttctg ttttgatgat tcacagttat cttatggcaa aaactaggaa ttttgctaaa
     8041 tcggttggag ttgcagcaat tggttccttc tcaggtttta tttttattat gctaggtggt
     8101 tttattaatc aattatttcc atattctcag ccgatgattg gtttacgaag tagggcattg
     8161 aatgatatgt catttttaga gtttatgtta tttattacag tgaactcctt gtatagtttc
     8221 attttttatt ggttaactgt taagaaattg gagaataatg aataacgtga tgataaattt
     8281 tttgtgtagt tcttcaacat agtagataaa atgaaactca gatccataaa ataatcgcta
     8341 tgctgatttt cgatttgttc ttgaaatgat agtaagcctg atttacgtaa agaatagaac
     8401 aacaactttc ttgcaaaatt aaatgataaa tttgcacgag ctattatcat aattacagga
     8461 atgacgcaat aattactgtc atattatgac aatttcccag cttttttctg aaagtgacat
     8521 atacttttct taggagaaag ctatatgtac caacggataa gggatttgag ggaagatcat
     8581 gatttcactc aaaggtttgt tgcaaattta ctttccttct ctcatacaaa ttatgcaaaa
     8641 attgagagag gagaggttgc cttaacggca gatgttctag tgcaactttc taaactctat
     8701 aacgttagta cagattacct attagggtta acagattatc cagataggat aaaacataaa
     8761 ataaaatagt ctctccttga tttgttcatt gacaattgaa taaaccgagg tgggactttc
     8821 ttatttgtcg agcaatttag tgagatacgc cgtgatagga gcgaaaatta ttagctataa
     8881 aatagagtgg ttctctatct gccataacca caaataagga caatgatact tctgaacgtt
     8941 caggctgcca tcgtaaaagg acagcgggtg aaatgcccat gaatgaatta accagtcata
     9001 cccacggagg aaattataaa attacaagtt atcaggaggg aaagttttgg aacaatcagt
     9061 tgtaaaatat agtctgcagt tatcaatgct taatttttta tactctaaag aattgttgtc
     9121 taaaaatgaa tacgaaaaaa tcagaaacag actgcgtatt aagtacacaa aatagctgac
     9181 ctttttattt gaacgcggta atatagaata aaaaggagga ttttcagtat gaaaaaaaat
     9241 aatgttgaaa taataaaagc tgattcttta gttcgacgta gaggtgtcaa tgtagaaaga
     9301 catttaaaaa gggttgctgc ctattgtcga gttagttctg atagcgatga tcagaaaaat
     9361 agttatgaat ctcaggtgag acattataaa gattacattt ctcagcgttc ggattgggaa
     9421 ctcgtagata tctacgcaga tgaggggatt tcgggaactc aagtgggaaa gagacaagat
     9481 tttcaacgtt taatcaatga ttgtgtaaat ggagaaattg attatattgt aacaaaagca
     9541 attgctagat ttgcaagaaa caccttagat actttgaagt atgtcagaat gttaaaggat
     9601 atgcaaattg gagtttattt tgaggaagag aacattgata cccttactat ggatggagaa
     9661 ttacttctaa ccattcttag ctctgttgca cagcaagaag tagaaaatac atctgcacat
     9721 gtgaaaaagg gcttaaaaat gaagatgcaa cgtggtgaac tgatagggtt tcaagggtgc
     9781 ttggggtatg actatgatgt agaaaccaag caactttcta tcaatacaaa agaagcaaaa
     9841 atagttcgtt atatctttga aaggtactta gaaggtattg gagggaaagt tatagcaagg
     9901 gaacttgatg aactaggtta caaatctccg agaggattag atcattggaa tgatacaacg
     9961 gtcttaggaa tcataaagaa tgaaaaatat aagggcgata ttctaatggg aaaaactttt
    10021 acagttgatc caataagtaa gagacgattg agtaatttgg gtgaagaaga taagtactac
    10081 atcaaagata atcatgaacc tatagtatct aaagaggact ttgaaaaagc acaggcgatt
    10141 aggttgcgaa gggcaggaaa taaaaagaca gctgcaaatg tgaacggaaa acgtgaacgc
    10201 tattcaaaaa tgtatgcttt cagtagtatg ttagaatgtg gcttttgtgg ttcattattg
    10261 tctaggagaa gttggcactg tcgttcagat tatcgcaaag ttgtgtggca ctgtgttact
    10321 tcgataaaaa aagggaaaaa atattgtaaa catagtaaag gattagaaga actagctatt
    10381 gagggagctt tcatggaagc ttacagacaa ctctatcatt caaatgaaaa tttaatgaca
    10441 gacttacttg aaacgattga atctgaattg aatgacaata gccttaacaa ggaactaaaa
    10501 aggattacaa acaaacttcg aacattactc aaaaaagagg agaatcttgt aaatctaaag
    10561 ctcgaaggga aaattagtga taccatatac aatgaaaagt acaatgaaat ttcctcagaa
    10621 aaagtgtttc tagcagaaga gaaggtaaat attgaaacaa ccttaaaatc agaaatcgat
    10681 gtaaagaaaa gactaactga gtttaagcac ttgctatctt cacagaaaat gcttacggag
    10741 tttgatcgtg cagtttttga aagtattgtt gagaaaatta ttgtaggtgg agttaatagc
    10801 gacggagaaa ttgatcctgc aatgttaacc ataatattca aaacaggtga aactcaaaac
    10861 aaggatggaa accaattcaa aagtaaacgt aaaaatgcta aactagaaac agataaattg
    10921 tgtcctcaaa acagtgacga ggataaaaaa atgtattctc aaggaccaga caacacacat
    10981 cgagtgtgta ggtctgctca ctcgtgtgga acggtgatat aataaggttt tgagcagctc
    11041 gggggaatcc tcggattgcc ctttttccgt gtaaaaatga ctttttcatg gcgaaccgta
    11101 gagttgacag aaatgttatg gagccttgag ttgacgggtt ttacaccgta gagttgatag
    11161 cttagatgat tttggtaacg gttacgtgat ataatatatt atcgaaattc catgggagac
    11221 aaggttatga agcagatttt tatattctaa gattcacaaa aagataatat ttcatatttt
    11281 gaacgtgagc cggcaatgct agtttccatg aatcgcagtg acttgcctta tctaaaagaa
    11341 caagactttg cgagtcatac agctatctat gttttaattg gtggaaataa acgctacgtg
    11401 ggcaatctgc aggccaaacc atttatcaac ggttatatca acacttttct aaagaagata
    11461 agaaatgggt tgagtcagtt ttatttttct ccagaacaga tggaaaacta tcaaaagctg
    11521 ataccgatta tttggagaag cgactcattc aagatttcac tgagaaatca gattaccaaa
    11581 tgatgaattc aactattgga aacaaatctt atattgggaa gctttcaaaa gcccagtcag
    11641 atcaattgta tgagactgtt tttgagatca ttgatgatat tgcaaatatt gatctgtttg
    11701 gtgtttcaga gggtgaatta acgaatgagg ttagtccatc agatatgttt gaaattcaat
    11761 atgatggtca tacactacaa tcaaagtctg caagaggtct gtttgttgat ttcgtaaaat
    11821 caatgcttgt cgacgataaa tacaaacaac agatagaaga gttaatagcg ccaaatgcac
    11881 caactgctgg agtcgtttta ggtagaaaag tttcaactta taatggcaga ccaatttcag
    11941 cagaagtggc tccaggtgta tggctattca caaatttttc aagaaaagat actaaaaata
    12001 agcttgaaaa gttaactaag cagctaggaa tttcagctaa aattaattgg aaataatgac
    12061 gggtgcactc tggtgaatga ttccctagag tgccttttta tcactcaaaa ctccaaaaaa
    12121 gtacataata agtttaaaac ggttaattat aaagtggcat tctgtgatat aacaattcta
    12181 tatttataga ataatattcc acttttgtgg acggaggaac tacatgggtt ttagttatga
    12241 acgactgtgg gagttaacgt tgaaaaggag aattaacaaa acatctttga gagatatggc
    12301 tgggattaca aattcgacat tatctagatt atctaaagat gagactgttt ctatggaggc
    12361 acttgcaagg ctatgtgaag cacttcaatg tcaactagaa gagattattg aatataaact
    12421 tgaaaataag gatagggttg aatgatgtgc tatttgggaa ataagacaaa attgttaact
    12481 tttattgaga aagttattga caaatataaa attgagggag aaacctttgc agacttattt
    12541 gcaggaactg gttcgatagg agattacttt aaagggaaat atacggttta ttcaaatgac
    12601 tatatgtatt tttctaaagt aataagtgaa gcaaagcttt cgaattttaa gacaccagat
    12661 tttaaagagt ttcacaagaa gtatggagta agtccatttg aatggctgaa taaaaaacag
    12721 tataaaacgg aaaaaagtta ttttacctat aataactaca cacctctcgc tgatagaatg
    12781 tattttacgg aagataacac attgaatatt gatggaatga gacttgatat agaagagttg
    12841 ttccatgaag gctatatttc aaaagcagag tattcgtatt tgttagcatc attattagat
    12901 tgaattgcta gatgctctta tagatttctt cttaagattt gaaaaaagag tgagatagat
    12961 aaccctaaat ttgtcgaggt aataccttta acgatgactt tatactatcg ttaaaaggtt
    13021 aagtggatat attcccacat aagaaaccaa actgaaaaac tatcagtact taaatgaggt
    13081 cgtcatcaag ggggagatgc tcttcattgt ctcctctctc atggagcttt ttcccctttg
    13141 tgaacttgct gggagtagag atatcgacga tatcatctat aatcgaggca tcagtggttt
    13201 gaatacggat gaatttgtcc agcatatcca ttccctgctt ttggatttga gaccgactaa
    13261 ggttttcagc aatatcggta ctaatgatat aaccgaggag acttatggaa atcagtggtt
    13321 ccaccatatg acggcgttca cctatatgcc aatgtctact taaaggtcta tgaatctctt
    13381 gaaccctacc tattggatta aaaaaatatg agagaatttc cagttcttac tcgctttttt
    13441 cccttgatta cagtacaata gacgtcaaaa gtgaaaaatt gaaatgaggt atccctatgt
    13501 ggaaatggtt taagcgactc cttatcctcg tcattgtgct ctttttggca gtggtggctc
    13561 tacttattcc ggacaagatt gatag
//
