LOCUS       gnlProkkaDGNHLIAC_1    17051 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DGNHLIAC_1.
ACCESSION   gnlProkkaDGNHLIAC_1
VERSION     gnlProkkaDGNHLIAC_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 14:48:17
            Original ID  :: gnl|Prokka|DGNHLIAC_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17051
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17051
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4626:7051]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4627..7051
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17051
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17051
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             175..288
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MPTKIWLKPEQLDLYIKHLERFRDLYSKLDCSGIVNL"
     CDS             517..618
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             788..1057
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1217..1516
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1616..2527)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2757..2846)
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2843..3445)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.2e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3539..4630)
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4627..5946)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_9"
                     /sec_met_domain="Streptide_RRE (E-value: 9.3e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.6e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6016..6108)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6191..7051)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.7e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7291..8127)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8121..8687)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8866..9024)
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9036..9167)
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9177..9689)
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNANQSKTNQTETRTVNLNYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPS
                     LPNTTTK"
     CDS             complement(10089..13268)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 497.2; E-value: 1.7e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIHKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13265..14473)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_18"
                     /sec_met_domain="Metallophos_2 (E-value: 4.1e-10, bitscore:
                     31.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 gtttatcaga taattgacgg taaaatgaca atcctggaga agtaatttaa tttatgacta
       61 aaaatcagca aaaatataat tatgactaag gaatatttta ttaactaaat gttgagatag
      121 cacaaggaaa tatttgtgct atctttttta tttattagga aaagagaaaa aattatgcca
      181 acgaaaatat ggttaaaacc agaacaatta gatttgtata ttaaacattt agaacgattt
      241 agagacttat atagtaaact agactgttct ggtatagtaa atttgtaaca ctcctaccta
      301 ataagttaaa ctattcatta gaataggaga cataacatga aacactatcc agacgaaaca
      361 cgataaaaaa ttgttcgact gcacattcaa gacggatgaa cattaaaaag cttagctgct
      421 gaatatggcg tatcccaagc ctcaatctct aattgggtaa gacattatcg caaagaatgc
      481 caaactaata ataaagaaaa atcacagctt gaactcatgg aggaggttcg taaattacgt
      541 caagaaaagg cagagcttga aaaggaaaat gatttcttaa aaaaagcagc ggcattcttt
      601 gcaaaggaaa tcgattagag gcatatcgtt ttattgataa ctataaagaa gattttggtt
      661 tgcgttggtt gttcttgcat atgaatattc atcccaatgc ttattataat tatcttaaaa
      721 agacaaggac taactatcat cgtcaaaaga aagctattct taatactatt cgagatatct
      781 accatgagtg caatggaaag aagtaaatca attcttcgaa acagaaagca tcaaactttc
      841 tgatatagag ccttcgaaag ttagttatag ggaggtacaa aggaatcaaa tcaataccac
      901 tatttataat gaaaaaggta atataaagga tattgatact agcattataa gagatatgta
      961 cgataaaagc aaacctactt taaaacaggg agcctatata tccgctatag cagcttctct
     1021 agaagggggg tactgcattt ataacagcaa taattaaaaa aagcgcttag ggaaaactat
     1081 tagtgagttt acaaaagacg attgtcttga aatttctaaa gatagtggaa ttggagctat
     1141 aaaaggaagt actcgaggca ttacgatata cgccctaacg aattacacag ctactcctgc
     1201 agcagtagca agttcattgt gcactgcttc atttggtatc gctaaagaag catacaaatt
     1261 ccgtaaaaac ttaatcacaa aagaagaatt tttactaaat tcgcaaatat tatgtgttga
     1321 agtatcagtt agtgcattat cctcaatatt aggacatgct gtaattccaa tacctatttt
     1381 aggatccgtt attggaaata atataggaac tttcctatat gaaatcgcta aagataatct
     1441 cacaatgaaa gagaaattac tgatagcaga ttatttcaaa gagatacaag aatataacta
     1501 ttttttagat aattaatttg aattatataa tcatcaactt cagagagatt aagaattact
     1561 ataaactttt agggaaggca ttttctcctg actataatat cgcttttcag ggatcttatg
     1621 aatttttaaa tatgtttttt aaaaatacgt taacctctcc tattttctct gcttcaggta
     1681 aatagataga aacggttgtc gaataaacaa aagaaggtac actcacaatt gaaagcaatt
     1741 gactaataac tgcataaata gccaacaatt ctactcctaa tctcgacatc aaggcatcaa
     1801 acaccataat aaacaaaaca ctctccagaa tttcttgacc aaccaaagga ataccaaatg
     1861 ttattaattc aaatttagtt gtagatgtaa tggataaagc cttcaaaatc attggataaa
     1921 ccataaacaa gtaactaagc gatatgaaag ctaaggatac aatcgttgat atggctgctc
     1981 ccttaattcc gatttgtggt accagtacat aatttaacac aacatctatt aatgaactga
     2041 taagtccaac ccacataatt ggttttgttt tcttttgaac tcttaataaa tttgtcagcg
     2101 aaaagtttaa taatgtcaat ccgatatatg gagacatgaa gactaaataa atggtggata
     2161 aggacaatag ttgcccttta aatccataga gctgcttcaa gattacattt ccaaaaataa
     2221 tgacaaaaac cgcaaaggca actccgataa ttaaatctaa ggttagattt gatttcaata
     2281 aatcatcaaa cctgttagtt tgccgattag agtacgcctt agagctttta atattaaatg
     2341 acaaactgaa tgctcctaaa agtccaccaa aagcaaataa gagattctga ataatggaaa
     2401 ttcctgacag agcaattgag gaattgttca cagcaaaatg caatgctatc tgcccaataa
     2461 ttacttgacc aatatttgtt aaaactaagg gaaaggcaaa tttgttaatt tcttttgaat
     2521 ctatcatttt tcctctctaa aaggcttcaa atgtaagtaa agatcagatt taactaaatt
     2581 tgcataaata atatgcaaaa taggagtttc ttctaaaaat gaaataattg cctgcttaca
     2641 atcattagca gatacctcat aatcttgctg taatagttct acaatcttgt ctaaagaaaa
     2701 atttttagaa atgcaataaa gtatttctgc tcctatttca tcaaatgaat agtactctaa
     2761 tcaagtagat cgtatcctat gtattcatct gctactttat ttacaatgaa atctctctta
     2821 cctcttatca caaaatgttc tttcatacga ctactccacc tcctttttgt tcataaaagc
     2881 aggctaaatc agagcccagt aacgttccat ctaattccaa ggcactgcat cgacatcccc
     2941 caccacacca tggtagggga cattctgaac atttcccaga aatatcatca aatgtaattg
     3001 atcttagttt attaaataca gcagaatggt gccaaatttc gctaaacttt tgttctttaa
     3061 catttccagc aactaattca tctataccat tcatcaagtc acacccgtat acatctcctt
     3121 tatgattaat tgaacatgct ctaactccag cttgacaaga tatttccctt ggcttatcaa
     3181 aatttatatc tactttttga tgccaaacat tttctaataa atctgatcta ttataaaatg
     3241 caagcggaaa ataatgtgtc aaaaaaacat cactttcatt aggaggaaca attttaaatt
     3301 taactttgaa ctctccttta gaaatccgct ctgttaaatc aagaaaaaca ggataccatt
     3361 gttttttatc tgctaaaata ctaccgtcat tagccctacc agtaggacaa ataaccataa
     3421 ctgacatata ctcaatacca agcatatcat tcaatcttat actctaaaga aaatatctgc
     3481 taaatttgca aacaattgtg ctatcaataa tttggcaaat gaattagaaa tacaactttt
     3541 aagttctttt ctctctgtta gaaaatgaat aagatactaa gcaacaaaga gctactatac
     3601 caaatattaa ataattgctc ctaatactaa agttatcagc aaaaatacca gctaggaaat
     3661 cagctaacat aaaactaatc gaaataaaca aattatatac tgaccatgat actgctctat
     3721 ttttttctat tgacatatta aatttataat aaaaatgatt attgtagttg gaattaagaa
     3781 cacgcattaa taaaaggatt ataatttgga tgattagatt agtttgaaaa aacatgagta
     3841 tagctaatac tggtaacatc aagcttactt caaacttaat ttttagataa ctccccaaag
     3901 ccatagatat attaaacata aatagtataa ttcccagcat atctagtgaa agtccctgtt
     3961 catttaagaa tatccctgca taagaattgc taatcataat tagagttgag aatgctactc
     4021 ctaatattat taataaccat ggaatatttt gaatattatc gaggctaaaa aatttttgtt
     4081 tattattttg ttccttttta atctcgggta atcctattaa atataataaa ctgaaaatta
     4141 caaatacaat ggatataata ataggataaa tataattcct atgcaataaa ggtggagata
     4201 taatcgtaat aatagcaata aaaatatatt ttaatgtgtt gagatttttc aaaaatgatt
     4261 tatatacaac ttcgtcatca attatttcaa aattataaga aataagaact cctgaagata
     4321 atgattctga caatccaaaa aatatcgctg aaatatatat tatatttgat tttccaaaca
     4381 ataggcccca taatgctaaa attaataata aatttgaaat agccaaaatt ttcttgtaac
     4441 caatcttact tgaaatataa cttaaaggaa tatcaaaaac tgagccacat agctcagtaa
     4501 taactgataa agtagctatt tctgtgaacg aaaaacctaa gtgctttaat agtaaaattc
     4561 ctacaaagta gtacggtaat ccagatagaa acatattcat tccgtataaa ttaaaaatct
     4621 tcttactcat aagttacaaa ctgggtctct aaaatatttt ggactcttct ccttaatcaa
     4681 gttaacatag cagccaccct cgcaaatttt taacaatcca caagataaac acttagaatt
     4741 cttcgttcta aaagaacgaa tccctccata caacggatca tcataccaaa catctaacaa
     4801 atctttttca aaggcattct gcttagtttg attaactcct aaaaaagcaa tgcaaggcaa
     4861 gatatcccca ttagacatta tttccatctt agtatatttt gcacgacatc cataatacat
     4921 ttcgccaaac tctgaaaatt caattgaatt atttatcaac tccggataag cggtgaaaag
     4981 atgacatccc tcagtagcaa aatttaaatt agcttcccgt tgagttatat aatctgtaac
     5041 atactcattc aaccttctca aatcagctaa atcgtatttt ttctttattt tcgtatatcc
     5101 tgttacctca gaataattag ctactgaaaa tctatctatt ttattctcta tacaaaaatc
     5161 aaccaattct ataatctgct catagctttg ctttgtatac actgcattaa ttctacattt
     5221 ttttccaacc tctttaaagt acttcgctaa tttaatttgt ctatcaggtc tcacccccat
     5281 taattcaaaa tttaatttag gatctaaagt ctgcaaagat aaaaccggtg taatatattt
     5341 agatttagct agaatttcca ctgtactttt ctttattaat tgggcattag ttgttatagt
     5401 agtctttatc ttcagttctt cacaagctat caacaaatta tcaatatcaa aatatctagt
     5461 cggttcccct cctaaaattg aaacacttaa cactccatta tcttttgctt ggcgcaaaat
     5521 tctttcccaa tctttagcag gtttggcatt tctatcttca cgatttgcta aaaaacaaaa
     5581 accacatttt aaatcacagt acatactggg gtatattact agttcaagcg gaaaactcaa
     5641 tatgttatgt ttttttaatt ttgctacatg ctttctcgca ttttgaagag tctcgtcagg
     5701 atttttcgat gatccctcaa tattattatc agaatagata tttaataaga gtactcgctc
     5761 tagtttccct gcttttattt ctttcttaaa aaaggacgta gcaatttcaa aaccatgatt
     5821 ttgaaccaaa taaagaaaat aagcttcact ctcatctaac tcaattcggt caaaagttac
     5881 tttatttatc aaaattccac caaacttttc tagtctaaat aaaaaatctt ctgaaattgt
     5941 catcatattg aatacctttc taaaaaagca gaggaaaata tagcctctgc ttaacttatg
     6001 ggataaatta ctttatcact cccagccgtc accttttgcc atcaccttcc agccgtcacc
     6061 ttttgccatt gaactagact caaggacttt ttcaagctct ttagacatat ttggtactcc
     6121 tttcgaatat gatactgtga ttatatttct tttcaacact tacaataaaa tattcccata
     6181 tttgcatttt ctaactacta gctaaaattt tttctaaatg tccttcataa gtctttgcta
     6241 agtgatgact tcctgctaat ttcatcgctc caacacactt cttcatttca ataattgctt
     6301 tcacatttcc atcctcttta tattgataaa gattttgtgc atacttaaag actaaacgtt
     6361 catatacttc tgtctcaata aaaaagcatt gatttagctg cttttcaaaa tataaagcat
     6421 ccataaattt ttctctttca acacatgtaa tatatccatt taaaagcatc gttgaaatta
     6481 atcgtctgtt atttggaatt tctttgtaaa aatcagaacg cctaaacatt tctcttgcta
     6541 agaccatgaa aacatcatga tttaatacat ctaaagtatt cgagaaaatc aataactcat
     6601 agtaccccca gtattctaca ctaaagagat aatctgttaa atatgtcaaa tcatcctttg
     6661 tatagtaagt ttctcctgat aaatcctgta gacgaatttt caataaaata atattgattt
     6721 gatgaaattt ttctcgccta tcttccagtt ccatctgaga ataaagtaat tttttcatac
     6781 cttctacgtc acgtgttgac acaaaatgac gtactttcga taacagttcg tttaactcat
     6841 ctctatgaaa atcatggacc gcatacataa attcatctat tggcatattg atttcatcta
     6901 aaataaacat gaactttgaa atcgttaaat ctgtttctcc tttctcaaat cgagagagct
     6961 gagacgttga tataccagcc tttgcgacgt cttttaatcg taatcctctc gattctcgaa
     7021 actttttaaa aatttctcca aattttttca tactacacct ccatcacgca tatatgggaa
     7081 taattttcat ttgctttcat catatcatac aataaagaaa aacaaaagtg aggattatca
     7141 catgaaaaag caaattttac taacacttct tcttgtcgta tttgaaggca ttatcgttat
     7201 cgtcgtggga taaagagtct gggacaaaag tcctttagct ccaaaaagca acggcataat
     7261 gtactgaccc caaaaagtta gacaaataat ttaagtaaag gatttagttc tgtattgtac
     7321 aggactgagt ccttttagtt ttaccttaat gcgtttgttg ttgtaataat taatatagtc
     7381 tgcaattgct tgttccaaat gctcaattga cttaaacgtc ttctcataac cataaaacat
     7441 ctcagactta agaatgccaa agaaggattc catcatgccg ttgtctggac tattgccttt
     7501 acgtgacatg gatggttgga ttcctttctc ctctaaaaaa tgatgataga aatcatgttg
     7561 atattgccat ccctggtcac tatggagaat tgtatttttg taatgtttct ctgtaaaggc
     7621 ttgttctaac atagctttca cttgtatcaa gttcggtgac ttagaaagat tgtaggcgat
     7681 aatttcacta ttgaagccat ctaaaattgg cgacaaatag agtttttggc tgcttgctgg
     7741 aatggcaaat tctgttacat ctgtgtagca tttttccaat ggtttggatg cttcgaactg
     7801 gcgttggatg agattctctg ctttcatacc aacctctcct tgatatgaag aatacttacg
     7861 tttacggcga attctagcgg ttaaaccaag tactttcata agacgttgaa ctctcttatg
     7921 attaatcaca attcctcgat ttctcaattc aagagtcatt cgacgatagc cgtaatttcc
     7981 tttatgctca gtaaaaatgg cttgaatttc agctttaatg tcataatcct tatcattttg
     8041 atccagctgt tttaagtggt aataataggt tgaacgagca agcttaataa tctttagaag
     8101 catatctaaa gaaaactcag ttaccaatcc tcggacaatt tccgtttttc ttcttgctct
     8161 ttttcttccc tcaatcggag ttctctcaac tttttaagaa ctgcattctc cgctctaagg
     8221 tactcatttt ctgcttgaag acgttccatt tcttccagtt ttttctttgg cttacgtccc
     8281 attttagata accttcctct tgttttctca acaatagtat acccgttttt cttatagtgt
     8341 gcgagccagt taggaagcgt cccacgattt gggagagcat attcaagaga aactctatct
     8401 tgagaatagc ctttatatag gactttatca atcatttctt gttttaattc aggagagtag
     8461 taacgattct ttcctttttt agcgatttct attccgtatc gatcaatcaa tttaatcatg
     8521 tagctaagat tagaaatgtt tatcccaaat ttatttgaaa gctgatctaa gctatatcct
     8581 tggtttctaa gttcatagat ttgaacctta tcttcataag tcaatttcat aataaaaaca
     8641 ccccgaaagt tagatttttt ctgtctaact tttggggtgc agttcataaa accgttgctt
     8701 tttgcatgat tgtgatagac ttggtgaaat agaattgacc aaaaatcttc tgaaatataa
     8761 caagagagtg actcgaattt aaaaagctag agttccacaa ttggaaatct ctagcttttt
     8821 tgtgactgag aactttttgt cccagcctct actttctact gactactatc ctgcatgccc
     8881 taagtcgaga tagagaatat ctcgcttagt ggcatactct agcgcatgtt caacagcctc
     8941 aaataaatct gaagctagaa accttttcgt aaagacggtt tcgtctttac gcttaaattt
     9001 cgcaacataa ctatgtttag tcattttttc tccttctaat attcatattg tcctttaaca
     9061 ccactataga tccagtaaac tgctttatca taaacttgtt taaaggagat acctaatcga
     9121 ttggctacat caagaattga aatttgctta cattcctcta tattcataaa atatcatcat
     9181 tttgtcgtag tattcggcaa tgatggaaca gatgaggatt cttctaaagt tttaggagtt
     9241 gccttatcta gatcatctaa cccagatttc caaacctgta cttggttgac caataactta
     9301 ccaggtagtt tcgaatagtt caaattaacc gttctggttt ctgtttggtt tgtctttgat
     9361 tggttggcat tctttaaatc agatacataa gttacattat aagagaccat ggcaatggct
     9421 tgattcgtag tctgattgac aaagatatct gctttttcaa aatgataatc caaaatatag
     9481 tccttataca cttggttcat ggcatcattt tgacttgtca attcttgaga ataggccgat
     9541 tcagtcatat aaggttgaat acgtgtatta ttttccccta gtttttcttt cgtatagtac
     9601 tgtgtcaaaa attcttttac agtatctgat gataaaatac ttgctttatc ttctgcttgt
     9661 ttgtcctcta caagtttagc tgcagccaat tcgatttctt ttcgactttg tttggcagta
     9721 gaatgttgac caatagaatt agcagtaagt tgtggtgttg atgaggtgga tatactaaaa
     9781 aatgaggagg aaattgataa ttacttcacc tagctaaaag ttcaacgaat tagggagaca
     9841 ttaggtagcc tcatattact ttgattagtt tttgctataa cattgtcaaa tatgatgaca
     9901 aaaaaatccg tccgcacttt tttacgagta ggacgaatta aatatgttat acaaaccatc
     9961 agctttttaa caattctaca taaggtagtt gttgatgcaa ctaccttttt tctatgctga
    10021 ttagaacaaa tttgacatgg ctacaactgc gattatctga tatagagtat tatataaact
    10081 gattcctcct accccttatc cacaatttta atacggctac tgccatcgtg cgacttgatg
    10141 ataactagtt gctgagcaat accttctttc atatcgtcta cgtggctgat gacaccgacc
    10201 atgcggtttt caccgatttg ttccagaaca gaaatggcct tggtcagggc ttccttatcc
    10261 agtgagccaa acccttcatc gatgaagaga gcttcaacaa cggcaccctt gctggtattt
    10321 tggacaactt ctgagaggga tagggcaatg gccagtgcag cgataaaggt ttcaccacca
    10381 gacaaggatt taacggagcg ttcactacct gtcagctggt catagacgtt gatatccaaa
    10441 ccgaagtgat cacgcgccct gcgtccttcc tcacttagaa caaaggaata gcggttatcc
    10501 gttaatagtc cgatgtagtt agcattggca tagtccaaga tttgttggaa atactgacgg
    10561 ataacgtaga cctcaagatt aagacgacca gttagagcag tattttctcc cttaaccacc
    10621 ttaaccaaat cactgagttc ttggtgggcc ttaaaggcct cttggttact gtcttgaagg
    10681 gttttagccg cttggtaggt agccgtcgca tccttaagtc ccttttccat gacagaaaac
    10741 tgagcgagct gcctatcata gatttcctga caattctgta ctgcttgcgc tagactatcg
    10801 agatctggtt gttcttgatt ttggagaagc tcttgcccct tatgaatctg cgcctgtaat
    10861 tcttgtttga gcgttgcata ggtcgttaat ttggcctgaa gcataggaat agcttgatta
    10921 tttacctcaa taagccagag ttcgacctgc tctaagtcat tagcgagggc tccttcagcc
    10981 ttgagacttt gctctaattc agcagataat cgcttaacat cttgatttac cttatcttta
    11041 gacttagtta tactctcaat ctgccccttt attcctttaa tgtcggcatg aagttggttg
    11101 taggcttcgc tattttcctt gacttgctta ttgtagaggt tcagctcctg atgagcaagg
    11161 gaaatccgtt cttgatatac ctcaacagac tcaagttctg gatgagcttc ctgcaggtcc
    11221 tctaggcgtt cttgagcttg gtcaagcact gccttggcct cttgataggt tttagccaaa
    11281 tctgtcgctt ttttttgagc cttacctagc tcatcttgat atcggatata atctgtctct
    11341 tccttatcat aacgtttttg taactcttga taatactgct caaccttcag gagtagggct
    11401 tgcccacggt cagtttcata gtctatcgaa aaatcaaaat caaaccgtcc cttaacgtgc
    11461 tcttctaatt cttgatagtg cttttcaaga gttgccttga ctttagccac ttggtcaagc
    11521 aaatcctgac gtttagatgc aacttcactc aaggtagcct gacgatttga taaagtagcg
    11581 acttgctttt ctttttgagc ttgaagcttc tccacctgat ccatgagatt tttcaaggcc
    11641 acttcatcag cctgtgctcc accaacatta gggtgttcca gagcaccaca aaccatacaa
    11701 ggatgcccct cctctaactc tgcctgcagt tggacaataa tgagttgacg gcgtgaaacc
    11761 aaagtccttc ttaactcctc ttccaattct ttgagaattt cttgagcttg atcaatatca
    11821 aaagataacg tttgatgacg tttttcggtc tttgtcaact cctgattcaa gttctctatt
    11881 tctttcaggt cctgagcaag ttgattctcc acactgtagc ccacaatctg gaagagtttt
    11941 tcggcctcat gtaaactatc taaactaaga cgattagcct ccaagtcaga caaggacttg
    12001 ttaagcatct caacctcttt tctagcctgc tgataggtct cttccaactg cttgtagtta
    12061 gtcgttgaac gtttgatttt ctcctgttct tgggcaagac tctgggcata gataatattc
    12121 tctttccaag tttcaagctc ctcttctttt tgaagaaaat ccttagattg aactgtgagt
    12181 tcctcttttt tagccttaac atcctcaaac gcctgttgct tttcacttaa ggcttcttga
    12241 gcaatttcaa ggtcctgctc taattgcatc aactgtttcc gatactgctt caaggtccga
    12301 atggtttcct gcagaccttg agcaaactgt aattcctcca gatgcacttt tgcctctgcc
    12361 tgtccttgag ccccctcctc aatttccaga cggtaacgtt ccttggcttg ctccaattct
    12421 tgaaaaatct ttgccaaatc ttgggcagtt tgcaagctct tctgcagttg tgccaaatcc
    12481 tcgtgggcag ccttcaagat acttttttgc ttcgtaacat tttcttgacg ctgagacaaa
    12541 aactcttcaa gacgtgtcaa tttttcagag gctggcgttt gctccaagac ggataattct
    12601 tcctcagacc aaacctgact ggcaaaatga ccatctagct gagcctgacg cttttccata
    12661 tccttattac tctgacgaag acgctcttcc aagctctttt gaaaatggtc aaaaataccc
    12721 gttccaaaga ttttctttaa aatttgagtc ttggtcttag aatcttcttt caagaaacgg
    12781 ctgaaatcat tttgtggaag gagaataatc tgtttgaact gctcagcatt gagccccaaa
    12841 atctgctcaa tctggtcact cacttccttg atcttatccc caagcttttc aatttcctga
    12901 ccaccaatct tatccacaat gactagagaa gccgtcgcct tttgcatggt agtgccccca
    12961 ccctgcttgg ccctctcttg ctggagaact cggtcaatgc gataaaggtg attgccttgt
    13021 tggaaataga aagtcacctt ggtcaaatca tcctctggac cagcgaaagt tgaccgcatc
    13081 tcctcaacat tacgatcacc actggtcgta gcaaacaagg ctaccgtcat ggcatcaaag
    13141 agagtactct taccagcccc tgtatcccct ccaatcaaaa agaggggagc atggtcaaac
    13201 tgagtgaaat taataacttc cttacgatat ggtccaaaat tggtcaattc taactggact
    13261 ggtctcattg tcgactcctc tcaatctcct caaaaacact ttccacaagg gcagtctgtc
    13321 tctcagataa gacatcgccc ccagttactg tctggtaaaa atcaaatacg atttcctggg
    13381 gcgactgcat ttccaaatct tttaagtgct gatcaacggt caagttttct tccctaacat
    13441 cacccagacg actgaaagta atttctacaa tgtctgtccc ataaatctct tccagtcggg
    13501 cacgcacatt gataccctct aattccttac gactagacag ttgaatatca aaggcgaacc
    13561 aggctttttg acaaggttga ttcttataaa attcaggtga catcaaggtt tcaaaagatt
    13621 cctgtaaagc cacaatcggc cgtttaacct ctagagtatg gaaggtctga gacatatcac
    13681 cagacgcatc caattcaaga atatagacac ccttttcttc cttacgcttg gcttctttga
    13741 cattaaaggc gactggactg cctgaatatt gcacgcgctt ggtaggacta gcaaaacgcg
    13801 tatggatatg ccctaaggca acataatcga aagacttgaa aaggtcactg gtcacattgg
    13861 taagaccacc taccgtatta ctggtttcag acaacatcaa ttctcgaaga ccctgaccat
    13921 cgctatcatc cttcttagaa accgcaaaat gcgtcaccaa gacatgagct ttgtcaggat
    13981 caaaagcttt ttccatatcc tcaagaatgt aggtcaaggc atcaccaatc ccctgaattt
    14041 cctttccctc atcatcctta tagtaaatac gagcatcaat aggatcgata aaaggcagca
    14101 gaaaaatctg gcaattctcc aactcaatgg gctcaaaagc ctcctccaaa cgtgtactta
    14161 aatgaaggcc ctgatgttga aagaagtcac gcccaaaatg taaacgttca gccccatcgt
    14221 gattaccact aatcgcatag acaggaatct gctcctccag taccaagcgg gccaaggtct
    14281 tattaaaaag cttaatcgca tccacagggg gcaccgcacg gtcatagagg tccccagaaa
    14341 tgataacccc atccactttt tcgctaatag ccaaatccac aatttgttga aaagcccact
    14401 cctgctcctc caacaaagac cagccattga gggttcgtcc tacatgccaa tctgacgtat
    14461 gtaaaaactt catgacaacc tcctcattca ttttgtctta cttctattgt accttatcaa
    14521 gctaaatact gcttaaaagt ttcacaggct ttgatagttt tcccgttttt tagctgtaaa
    14581 gatcaaaaaa tctctcccaa gctatcctgt actgacccca aaaagttaga caatttatgt
    14641 aagcaaagga tttagctctg tattgcacag gattgagtcc ttttagtttt accttaatgc
    14701 atttgttgtt gtagtaatca atatagtcta gattaccctg cctcaattgg ttaagtaatt
    14761 taaatacctc taaccaagaa aatcaatatt atctattctt ttaattgact tttatagatt
    14821 ctaagcatta tcatataggt tggtactagt gcacatcttg tattttaggc aataatattt
    14881 actcactttt cgttattgtc agtaccgatc ctttttaaat ttttcactat gaaaacctaa
    14941 aaataatccg aatcctaagg gctcctgact ttttacttta ttctaggctt tttttatccg
    15001 tagcttgtta gctgacttgg aactaggcat gtagtattta ctatttccct acttgagatt
    15061 ttttataagt cacatgcatt attccatctg aacgaatggt atgattttta tttcttttag
    15121 agaaacaccg gtaatagcta attcctatct taaatcactt gaaatatatt tataatgtgt
    15181 tggagtgcta atcagtaccg cttgtagatt tttggaagat actaacacac taatgattta
    15241 atctccttta aaacatgaaa agagaagcct ccaaagcttc tcttttataa ttatcaaata
    15301 atgtacaact agattcttaa taactaccta atttagtggt tcaatcatga agcttaattg
    15361 atagctatct gctgagctaa gcaagaattc gtcatgaact ggagcacccc atgtgtcgtc
    15421 accacctaca cccatttgag cagcaagaac tttaatccat gtagcatcag attcttgcaa
    15481 ctcatattgg tgacgagcat tttcaatttg ttcagtactg ttacgcaaag cactgaattc
    15541 gaatgcttta ttaagtgcgg tgaatttaag accattatgg ttatcatcag atactgtgaa
    15601 ttcacgagta ccatagtgat taccagattc ttgtggcatt agatatggag caaatgtctt
    15661 ttcaacagat gtttcatatc gaccaagata ggcaccagga agtttatcac ggtagctttc
    15721 ttctgcaccg tatccataat agctaaggtt tgtaaattgt gaaccgatag caaattctag
    15781 accaaattca gggaagtttg gcaaacctgc tttaccatca tagtttgcag taacaaagat
    15841 tcgacccttg taatcaactt gataagttac cttaacttcg acatcagaca agcctggcaa
    15901 ttcatgaaca taagtcactt taacagagtc gtcttcgatt tgaatttgag tatctgtaac
    15961 tttactatag tttccagcaa ccttccagcc tgccatttcg aatggatatc cagcaccacg
    16021 atcgttgtca gtgtaagcac gagtgaagct aagtttagga cctttctcaa tgaattcaac
    16081 accattatac ttagcagata ctaaagtatt ttgtgcacgt gaaagcaaga ttgagaagtt
    16141 ttgtccttga ataccgatgt tgaagtcgcc ttcaacaaca ttcaaaggtg ctttaactgg
    16201 tgtttcagtg ctaatctttt caacaacata ttgaccacga acaatttcat gacctttagg
    16261 agcccattca gttgcttccc tcagaacaca agcaacttcg taaatttgtt cagaatttga
    16321 agcctcgact acaaagttaa ctgggaatgt tgcttcttcg cctggtttaa catcaaagtg
    16381 atattcactt tcactaactt ttctaccatc ttcgtaaact ctagctagga aagtataagc
    16441 agaaagatct tcgaagagat tatcattctt gatagttact gatttttcat caacagcaat
    16501 cttaatatta gagtaaagat gtttaactgt ttgaagtttt ggagttaggg tacgatctgc
    16561 aaagacgata ccatttccac aaaattcgta gtcagaaggt ctatcatgcc agtcaccacc
    16621 atatgatagg aattcgctac catttggaag tgttttgtaa atagcttggt caatgaagtc
    16681 ccaaataaat ccaccttggt attctggata tttctctaag tcagtgtaga gttgcaatcc
    16741 accaccagag ttacccattg tgtgcatgta ttcacatgaa atataaggtt tttgaggttt
    16801 gttagttagg ttacctgaag caaagtgttt atcactaacg cttgaaagat caactagttt
    16861 accagttgtg aggtattctt cgatatcagc tggtttcgca tacatacgac tttcgatgtc
    16921 tgtaatgtaa tcaaactcac gacaccatgc aacaccttca tagtgaactg gacgagtatt
    16981 gtcaacacta cggaagtaat cagccatgtc agcaatatct ttaccagcat atgattcatt
    17041 accacaagac c
//
