LOCUS       gnlProkkaBJPHDPLL_80   16543 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BJPHDPLL_80.
ACCESSION   gnlProkkaBJPHDPLL_80
VERSION     gnlProkkaBJPHDPLL_80
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 14:56:53
            Original ID  :: gnl|Prokka|BJPHDPLL_80
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16543
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16543
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5837:6543]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5838..6543
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16543
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16543
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             54..968
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 190.6;
                     E-value: 8e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg61_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-32, bitscore:
                     104.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDSGLVRIKLVICQVNNNLADLGKQHDADITVLADAKEFFQALL
                     QSEVTIKPTKFLKAAQRDKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLD
                     VGNNTEWAIRQLPLNKQQTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAM
                     VMPDLLTEVKYHLPVINVVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAI
                     GFKVTNLKELKATFQKVTQLQQNGNQLPIVIDAKIKNVDQIDTSFVPVDPENFDADTIA
                     KYRERYGIAEADQPALSQLLNEL"
     CDS             995..2095
                     /locus_tag="ctg61_2"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWDFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIMEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQSPEDALLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHE
                     IAQAVNGRVPIIFDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHL
                     NDELLIDMQLAGTKTIEDVKRAKLLR"
     CDS             2732..2965
                     /locus_tag="ctg61_3"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             3356..5470
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     961.7; E-value: 5.4e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg61_4"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEAAKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             5838..6434
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_5"
                     /sec_met_domain="AgrB (E-value: 1.7e-34, bitscore: 111.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYV
                     IGTGISEVYRLLLSLIFVIIISIFAPADTVKNPITSKSLRKKLKRRAIGLSLILSLLQI
                     VSNNYFGTIILIAMALAALLLMPYERRENYERKNV"
     CDS             6415..6543
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_6"
                     /sec_met_domain="TIGR04223 (E-value: 7.6e-08, bitscore:
                     25.3, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKMYKVLSHLFQYVGTKQLVMCCHGILFETKIPDELKSKD"
     CDS             6553..7815
                     /locus_tag="ctg61_7"
                     /transl_table=11
                     /translation="MLMIVFQELSIYLIIKSLLRNIFFVRLFDVIFLSVCMLMSYIFLA
                     KLGISFSFLMLMMFIFFTWWYVRVLSGALCITFQVFIWSIMVDHICDILTRLMKVPNGY
                     VVVFVILSVVSLIFLNIVMDRTNFSPTFSNQSLNRITALLLMIIYLYIMLSEGLENQFQ
                     VILSNLIILSVVMGLVLVIYNEYLKNVRAKYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDITVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             7808..8551
                     /locus_tag="ctg61_8"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MANGEKVLCSAQANRYLAKWLAKKS"
     CDS             8907..9344
                     /locus_tag="ctg61_9"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(9502..10956)
                     /locus_tag="ctg61_10"
                     /transl_table=11
                     /translation="MTEKLTTETGQPWANNEHSQTAGARGPVLMQDYNLLEKLAHFDRE
                     RIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKKTPVILRFSQVAGEKGYPDTV
                     RDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFIHSQKRDPKTNRRTQNMQWDF
                     WAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVNQNGEQFWVKYHFISDQGVKN
                     MTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQILPYEEGLNYKWDIFDVTKVI
                     SHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPGIEPSPDKLLQGRLFSYKDAQ
                     RYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVNYEPNALHGTEEVPDAALSPD
                     SVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINTIKDALGQVTLPGVKELEIKQ
                     FYEADKNYGTRVANALGMNIADIISD"
     CDS             11302..11547
                     /locus_tag="ctg61_11"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             11564..11698
                     /locus_tag="ctg61_12"
                     /transl_table=11
                     /translation="MIKSILKFCLAATLIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG"
     CDS             11893..12441
                     /locus_tag="ctg61_13"
                     /transl_table=11
                     /translation="MSKLIAKNVFQLPKMNLLVLTTSAFLLALDVILYKIAIGPAYFQL
                     SFGFLSMACIGYLYGPIWGGLLEMISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLY
                     RKSVNWLSVVMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAI
                     FYFIKALEKRHVFDRMGLR"
     CDS             complement(12637..13008)
                     /locus_tag="ctg61_14"
                     /transl_table=11
                     /translation="MRLWHEQLIHQLPRQQLLGQHRELAALRGNGWGKNHATVNYVFKY
                     SPYKLYQFHVLVMDEMQLRGYHPNKIWYDPNYRGQFCPPYDHLTPIALTTPIYPEHNAS
                     YLAECVRNLAAKGIIMPTT"
     CDS             13476..14681
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 125.1; E-value: 4.6e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg61_15"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-53, bitscore:
                     175.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLDQTNNYRYVIVGGGMVAGYAIKGIRQEDPEGAILVISQEAD
                     VPYERPALSKKLWLDDEFTEENIRIGAENYPNVTFKFKTTVTAINRQDKVITVTDSEQI
                     KYEQLLLATGGEPRQIQGPADPHVLVFRQWSDYRKLRKFSGPNKRVVIIGGGYVGTELA
                     SSLTQNGTKVTMIFPEKALGEGKFPESIRAEYEATFKRNGVTLMSGQFVQSYQRQGDHL
                     TLLTKDGTVIAVDTIIVGLGVTPRISLAEDSSLDLADGGVKVNEYLNTSDPAIWSAGDI
                     ASYPDHILGRQRIEHVDHARLSGELVGRNMAGAHMSYQHTPYFYSMIFDISWQAIGNID
                     PKLQLIFDRRTHGTLVYFIDAGKLVGVLVWNVKVNLDDVRALLANAPATDDLVGSIREQ
                     AG"
     CDS             complement(14820..15506)
                     /locus_tag="ctg61_16"
                     /transl_table=11
                     /translation="MKNTFLNTVKGSLIISCQALPNEPLHSSFIMSRMALAAKEAGAAG
                     IRANSVVDIQAIQDEVDLPLIGLSKVDYPDSPVYITPTIKEMRGVAATGCAVVACDVTG
                     QPRPNGEKLAEIVTTMRTEFPDTLLMADTDTIENVKVADKLGFDIIGTTMHGYTPATTG
                     ANIADNDFAYLKEVLQATSRPVIAEGKVDTPEKMKRCLDLGCHAVVVGGAITRPLEIAQ
                     RFISAL"
ORIGIN
        1 acttgaacta attaatcaac gaccattaaa aatacatcat caacagactg ccattgaaag
       61 attccgggct tgttcggatt aaacttgtaa tttgccaagt caataacaat ttagcagatt
      121 taggcaaaca acatgatgct gatattactg ttcttgcaga tgcaaaagaa tttttccaag
      181 cattacttca atccgaagtg acaattaagc caactaagtt cttgaaagct gctcaacgtg
      241 ataagcaaaa ctggaaccgg tggctcaaga caattgctac tgatgatcaa ggagggttga
      301 cggctgaagg ggtgctagaa gctattaaag acaatgctac tgatgatgcc gtctttggtc
      361 tggatgttgg gaataatacg gaatgggcaa tccgacagtt accattgaat aagcaacaga
      421 cttttacgat gtcggcttgg tatggcacga tgggttttgg tttgccagca ggtttggccg
      481 cccaattgaa ttatcctaag aagcaggttt ggagtatttc tggtgatggt ggttatgcca
      541 tggtgatgcc agacttacta acggaagtta aatatcattt gccagtcatt aacgtggttt
      601 tagaaaacaa agtattaggc tttattcaac atgaaaagtt actcgctaat caggcgccgt
      661 atgggattga cttgattggt gctgattggg ccaagatggc agacaacatg ggtgcgattg
      721 gttttaaagt gactaacctt aaagagttga aagcaacgtt tcagaaagtt actcaactac
      781 agcagaatgg taatcaacta ccaattgtga ttgatgcaaa aattaaaaat gttgatcaaa
      841 ttgatactag ttttgttcca gtagatccag aaaactttga tgcagatacg attgctaagt
      901 atcgtgaacg atatggtatc gctgaagcgg atcaaccggc acttagccaa ttattaaatg
      961 aattataaag ggttatgtaa aggagattag tataatgaca gttattaatg gatatgaaca
     1021 gagtgatcgt gagcaaaagt taacgatttt aaatttacca tcattggaag cagctgctaa
     1081 aaagatcatc ccgagcggag gctttggcta tattagtggt gggtcagaag acgaatggac
     1141 tttaaagcag aatacaatgg cctttaacca tgttcaaatt gtgccacgag cattgacgga
     1201 tatggaacag ccaagcacac agactcaagc ttttggcata gatctcaaaa cgcctattat
     1261 gatggctcca gcggccgctc aaggattggc acatgcacgg ggtgaagctg cgactgctga
     1321 agggatggct caagttgggg cacttatggc tcagagtact tactcttcaa cgtcaattgc
     1381 agatactgcc gcagctggta aaggtgcgcc ccaatttttc caattatata tgagcaaaga
     1441 ttgggatttt aatcagagtt tactggatga agcagtgaag gctggtgcta aggcaatcat
     1501 tttgacagtt gatgcaacag ttgacggtta tcgtgaagct gatattatca acaatttcca
     1561 gtttccaatc ccaatggcta acttgactaa gttcagcgaa ggggatggta aagggaaagg
     1621 tatcatggaa atctatgctg ctgcggcgca aaagattagc ccggctgatg ttcggcgtat
     1681 tacggaatat acgaatttac cagttattgt gaaggggatc cagtcaccag aagatgcctt
     1741 gttagcaatc ggggctggtg ctcaaggtat ctatgtttca aaccatggcg gtcggcaatt
     1801 aaatggtggt ccagcttcct ttgatgtttt acacgagatt gcgcaagccg ttaatgggcg
     1861 cgtcccaata atttttgata gcggtgttcg gcgtggctcc catgtcttta aggcgttagc
     1921 caatggtgca gatctggtgg cacttgctcg gccgattatc tatggattag cattgggtgg
     1981 tgcgcagggt gtcgcttccg tagtgagtca ccttaatgat gagctgttga tcgatatgca
     2041 actagcggga actaagacga ttgaagatgt taaacgtgct aaattactta ggtagtagaa
     2101 gtaatgctga atataatgtc tgaaatgaat ttaaaatacc tgatataata acactttagc
     2161 gttggttttg gtggaagtaa attctgctga gatcaacgct ttttattgta ataggaagat
     2221 gttctgaaca gaaatagctg agaaactaag acactgattg acgaattgaa gctatgccgg
     2281 cgttgaagtt aggatattgt cttaaaatgc acaaaaagcg tcctaaagca cccagctgag
     2341 tttttcaagt cttaaaacgg ttattcagac atacttggca atagtatact gtacacatgc
     2401 gcacatgcgc gcataccagt tttatttagg aggctgaatg tttcataatc tagttatgat
     2461 gacaaggttg taatcatgag ttttgttgtg agttattttt ctcataaatt aacttcaaag
     2521 tttcatagta attaggatat ttagagatcg atttttgatt agtaaccatc aatgcatatt
     2581 atactgagct gaacatgaat actagttatt tagtttttac tgaatagctg actccttaat
     2641 gtggacttac gccgtcaaca atgagaaaaa caaacacata gattcactga cgaataaata
     2701 aacctgaatt ctttgaacgg gagactttaa tttgagtgtt gaaaataatt attgtaaatt
     2761 acaacaagcg catgatcaaa aatgtcgagt ctcattacgg ttttataaaa caaatgggca
     2821 gatggccgag acagttggct atgtcactac gattgtaccg aaagcaattg catttatggc
     2881 aattactggt catcggcacc ttatccaact caatagaatc attactgtga gtttacagtc
     2941 ccaagaccgc cgttacgtca tgtaatatgt tttggtttat gattttacac gtgtgtcatg
     3001 attgctagta ttgatattta agtggcaata ttaacgataa ctagttggcc ttaacttgat
     3061 actgggtgtg ctttttgagt cgcagtctct taaattaaaa ttggtctgga aagtaacttg
     3121 ttaattcaag ttctttatca agggctatta aatagggaac cttgtaggga aatcaattca
     3181 ttttatgaaa ttgatttctc ttttgtttaa acaaaattat tctaattatt tctaattgat
     3241 tctataagca ctttacttaa cgatacataa aaatcgtgat acgattcagt tgtagtttta
     3301 aaggatatta tggtcactaa gttacacata taaattttta tggaggtgtt gtaatatggc
     3361 aaatttctac ggaaatgatc ctttttttaa caatgatatg gatgatgttt tcaatcaatt
     3421 atttcggcgc atggataatc aaaattcgga gcgtgcacgg tatttagtta atggacaatc
     3481 gctgacaccg gatgagtttg ctcaataccg agcaactggt aagctacccc aaaataataa
     3541 aacaatagaa gtatctaaag atggtaaaca ggctgttaaa aaagggggga ttttagaaaa
     3601 gttagggact aatttgacgg aacaggctcg tgatggatta ctagatccag tgattggacg
     3661 tgagaatgag attcaagaaa ctgcagaaat tttgagtcgt aggacgaaaa ataatccaat
     3721 cttagttggt gatgctggtg taggtaaaac tgcagtcgtc gaaggtctgg cacaagcaat
     3781 tgtggctggt aaagttccag aaacgattca agataaagaa atctattcga ttgatttatc
     3841 gtctttggaa gcaggaactc aatatcgcgg ttcttttgaa gaaaatatta aacagctagt
     3901 aaaggaagtt aaagcagctg gtaatattat tctattcttc gatgaaattc atcagattat
     3961 cggcacgggc gccactggtg gtgaagatgg tggcaaagga ttggctgata tcattaaacc
     4021 tgctttgtca cgtggcgagc tgactgtaat cggggctacg actcaagatg aatatcgcaa
     4081 tactattttg aaaaatgcgg ctttggcacg gcgattcaat gatgttgtga ttaatgaacc
     4141 gacggccgct gacactttac gtatattaca aggtgttaaa aagctgtacg aaaagcatca
     4201 tcatgttgta ttaccagatg atgttttgaa ggcggctgtg gattattcaa tccaatatat
     4261 accacaacgc actttgccag ataaagctat cgatttgatc gacatgactg cggctcattt
     4321 agcggctaaa aattcgcaaa ctgatgttga gacattggat caacgcgtta aaaaattaga
     4381 ggcagctaag gaggccgccg ttaaatcgga ggactttaca aaagccgctg atatcaagaa
     4441 gtcgatcgag gaaaccaagc aaaaaattaa aaaaacggat caaaaagaaa aaatcactgc
     4501 cacgattgat gatgtggcac aatcggttga acgtttaact ggtataccag ttgctgatat
     4561 gggcgctaat gatattgagc acttgaaaaa tcttgataag cgtctgaaaa gtaaggtaat
     4621 cggtcaagat gaagcggttg aaatggtagc gaaggcaatt cggcgtaacc gtgcgggctt
     4681 ttcagagggt gatcagccaa ttggaagttt tctgtttgtg ggcccaactg gcgtaggaaa
     4741 gactgaatta gctaagcaat tagccttaga tatgtttgga aataaaaatg cgattattcg
     4801 gctagatatg agtgaatatg ctgatcgtac agctgtgtcg aaattaattg gtacctcggc
     4861 tggatacgta ggttatgaag ataatgctaa tactctaact gaacgggttc ggcgtaatcc
     4921 atattccatt gtattattag atgaaattga aaaggctgat ccacaagtat taacgttact
     4981 gttacaagtg atggatgatg ggcgcttaac ggatggacaa ggcaatgtca ttaatttcaa
     5041 aaatacgatt attatcgcta cttctaatgc tggctttggt aatgaagcat taagtggtga
     5101 caagcaacga gatcagtcat taatggataa gttagcacca tttttccgcc cagaatttct
     5161 gaaccgtttt aatggaatcg tggaattttc acatctgact aagcaagact taagtcaaat
     5221 tgtcgatttg atgttggcgg atgtacaaaa aacgttagcc aaaaaatcca tcaaacttga
     5281 ggtaactaaa gcggccaaag attggctgat ggaacaaggc tatgatgaag caatgggtgc
     5341 gcggccatta cggcgagtaa ttgaacaaca aattcgtgac aaggtaacgg atttctacct
     5401 tgaccactta gatgtcaaaa acttgaaggc tgatttagtg gatgctgaga ttgtgatatc
     5461 ggcagcttag cttaaatcag tgttcataaa taactttatg taagaggaga ttgcttgata
     5521 gatctccttt tttcgttgat tttcaccatt tgatattaat ctattgagta atgtgaatta
     5581 gtgaaattaa gtctagtttg acttgtaatc taaggaaaaa ttaaggggga gtatcgatga
     5641 aactgattta tattaacgat ctttttatat gaaactttag tttcgtatga ataattaaac
     5701 tgatgtatct ttaaatgttt atttctagtc ttaaaacaat attgaataat taatctattt
     5761 atgtattctt ttcaattaat taatactgtt ttaaactgtt gatacaggta tgtatttgag
     5821 cattatagga gtgggatatg gaaaagccag aacaaaaact attgctttat aaattaagcg
     5881 accggttatt cgctgcgatt caaaagaatc ttcaactaga aagacggcag gcattactag
     5941 ttaaactagg cattgatact gtattaaatg ttattcctaa gctgataatt actattatct
     6001 tagcgttgct gctacacgag ttggtcccag tgttagtttt tatgggtagt tttttagttt
     6061 tgcgtggctt tgcctatgga cgtcacttga aatcggattt gttatgtacg atattaacta
     6121 tctttgtgtt tgtgggtgtg ccgtatgtga ttggaactgg tatttctgaa gtatacagat
     6181 tgttattaag tttaatattt gtaataatca taagtatttt tgctccagct gatacggtaa
     6241 agaatcctat tacatcgaag tcattgagaa aaaaattaaa gcgacgggca attggattgt
     6301 cattaatttt gagtttgtta caaatagtta gtaataatta ttttggcaca atcattttaa
     6361 ttgcgatggc attagccgct ttattactaa tgccctatga aaggagggaa aattatgaaa
     6421 gaaaaaatgt ataaagtact tagccatctt tttcaatacg taggtactaa acagttggtt
     6481 atgtgctgcc atgggatatt attcgaaact aaaattcctg atgaattaaa aagcaaggat
     6541 tagtgtagat atatgttaat gattgtcttc caagaattat ctatctattt gataattaaa
     6601 tctttgttga gaaatatatt ttttgtgaga ctttttgatg ttatattctt atccgtctgt
     6661 atgctgatga gttatatttt tttagcaaag ttaggaatta gtttttcttt tttaatgtta
     6721 atgatgttta tatttttcac ttggtggtat gtacgagttc taagcggtgc actatgtata
     6781 acatttcaag tgttcatatg gtcgattatg gttgaccata tttgtgatat attaactcgt
     6841 ttaatgaaag ttcctaatgg gtatgtggta gtgtttgtca tattgagtgt cgtaagctta
     6901 atttttctta atattgtaat ggatcgcacg aatttcagtc ccacgtttag taatcagagc
     6961 ttaaatcgca taaccgcact attattaatg ataatatact tgtatattat gttgagtgaa
     7021 ggtctggaaa atcagttcca ggttatatta agtaatttaa ttatattgtc agttgtaatg
     7081 gggttagtat tggtgattta taacgaatat ttaaaaaatg taagagccaa atatgaagtc
     7141 caaaagcaaa gaatacaaat acaaaatgat actcgctata tgaatgaaat cgaagctcac
     7201 tataatgagt tgcgacgttt cagacatgac tatcagaata tgttgatttc gatagatgaa
     7261 tatttgaaaa ctgatgattt agaaggttta caagaatatt atcaaaagaa tcttgcaccg
     7321 gtttcaaatc gggtgttaaa agaaaaatat aatcttgaag atttgagtcg ggtcaaagtg
     7381 aagtcgatta agagtatcct atttagtaag ttgagctatg cacaatcgca agagattgaa
     7441 gttcattttg atttaaagga accattaatt gacattactg ttaatgaatt ggatttagac
     7501 attgcattag gaattatgtt ggataatgca attgaagcat cggtaggaca tgctgatgga
     7561 gagattatga gtgccatttt tatcgaaaaa aatagtacgg tgttcttgat tcaaaacaat
     7621 gtttttgaac agttaccacc cttatggaag ctgaaagagg caggttattc cactaagggc
     7681 aagaatcggg ggattggatt gaatagttta agtaagattg ttaatcgcaa tgagaacatg
     7741 atactcgaaa ccagagtctt aggagcggta ttcttacaac gcttgacggt gaagcgagta
     7801 tctcagaatg attagtgtct atatttgcga agatgatccg aaacaattac aacaaatacg
     7861 gcaaatcatt actaaggtaa tcgtcgatca acagctagac atgagtatct gtttagcatg
     7921 ccaagatccc cacgaattgt tagacaaggt taatgcacag cagcctcaaa aggcaatcta
     7981 tgtgttagat attgccctta attcagatat taatggtatt caactagcta gccagattcg
     8041 tgacatgggc cggcgcagca agattatttt tatcacgaca cacacggagt tatctttgat
     8101 ggtgtttcaa tatcaagttg aggcattaga ttttattctt aaggattttc cagattcctt
     8161 gtatgagcga tttagcaagg ttttacacgt ggcacaagat cgttttcaaa ccgatgaaaa
     8221 tgaccaagac gactatgttc aaataaaaat tggtgagacg gtcagatcaa ttaatgttaa
     8281 aagcattata ttttttgaaa gttcaaccag tccccataaa atcgtagtcc atttggatga
     8341 tggtgaatta gaatactatg gactgttaaa ggacgttcct gatttgagtc ctaatttcta
     8401 tagatgtcat aagtcatatg ttgttaactt gaaacgcatt aagtcattgg acaagcactt
     8461 gcgacgatta accatggcaa atggtgaaaa agtgctttgt tctgcacaag ctaatcgtta
     8521 tctagctaaa tggcttgcta aaaagtcata atagttccaa ggaagtcgcc tgccaaatta
     8581 gtaggcgact ttttatgtgc tacgtgatga aaattcagcg ttattcgatt agaaattgca
     8641 gtggtatttg tcagcattac gtgtactggg ttcgttcttt cctaaaccgt ttaaaagtgt
     8701 acttaaaacg attatcctca gattattcgt cttaaaacgg tcggtatgtc ccttgttcag
     8761 agcctataat aaagatgtgt tcacggggta ttggattggt catgacagta acgaatgcgt
     8821 ttagtttaaa ggatgttgtg acaggcagaa gttaatgtcg atcaatacgc tgtgatgaat
     8881 tttaacgaga gaggggcaga ttaggaatga ttaggttata tacacaatca agctgtcatt
     8941 cttctagagt tgcacggcaa tggttggaag cacatgggat tgagttcaag gagaaaaatt
     9001 ttagtgttga ttcgcccacg gtgcaagatc taaaacgtat tttgagttta accgaacatg
     9061 gtgtagacga tattatctca gctcgatcta aagactatcc tgaaattgcg cctaagttac
     9121 ccgaaatgcc attgaatgag gcacttaaat tgttgtgtga tcatccgaag ttgttacgtc
     9181 ggcctatcat cattagtgat agtaaaattc aagttggctt taatgaagat gatattcgcc
     9241 aatttattcc acgaccagtt cggcgactaa agttcaatgc attgttgagt cgtctagatg
     9301 gtaatacagg ggatcacatt attaataaaa ggatggtcga gtagtaagct atatctaaga
     9361 ttttttgtta attaaagagc gacaagctag acttacacga tatgagtcta acctgtcgct
     9421 ctttagttaa taaccatgag acggcatcat cattctttat aacaaaaata atatcgcgct
     9481 ggataacatc cggtcaaaat attaatcact gataatatca gcaatattca ttcccagagc
     9541 attagccacg cgtgtaccgt agtttttgtc ggcctcataa aattgcttga tttcgagttc
     9601 tttgacacca ggcaaagtaa cttggcctaa cgcatctttg atagtattaa ttaagcgttc
     9661 ttgctcgggt tctgacatta agcgatatag gtcgcctgct tgagttgtgt aatcaacttg
     9721 atagcgataa ggctgtgcgc gtgtttcacc acgaacagaa tcaggtgaaa gtgcggcatc
     9781 cggcacctct tctgtcccat gcagtgcatt aggctcgtag ttgacctcag caccttgatt
     9841 attaattttc atgtaaccat cacgttcata attatgaact ggaacaaccg gcttgttcac
     9901 gggtaaatct tcaaagttgg cacctaaccg atatcgctgt gcatctttat aggagaatag
     9961 gcgaccttgt agtaatttgt cgggagatgg ttcgatacca ggaacaaaat ttgctggcga
    10021 catggccgcc tcttcaatat cggtaaagtt attagtggga ttctcattta aagttagttt
    10081 gccgacttta attagtggat agtctttgtg ggagatgact ttagtgacat caaaaatgtc
    10141 ccatttatag tttagacctt cctcatatgg caagatttgg acatacatcg tccatgatgg
    10201 gtaatttttt tcttgaattg catcatataa gtcatcttgt aaataatcta aatcttggct
    10261 cattgctttt tcagctgctt gagcagtcat atttttaacg ccttggtctg agatgaagtg
    10321 atacttaacc caaaactgtt cgccattctg attaacccat ttaaaagtat gggaaccgta
    10381 accattcatg gttcgatagg acgcaggaag tcctcggtcg cccattaaat aagtgacctg
    10441 gtgcaatgat tctggagaat gagcccaaaa atcccattgc atattttgtg tacgacggtt
    10501 cgttttagga tcccgttttt gtgaatggat gaagtcagga aattttaaag ggtcgtttac
    10561 aaaaaagacc ggtgtgttgt ttccaacgag atcataattg ccttgctgag tataaaattt
    10621 taaggcaaaa ccgcgcacgt ctcgaacggt gtcaggataa cctttttcac cggcaacttg
    10681 tgagaacctt aagattacgg gagttttctt accgacacca ttaaataagt ctgccttagt
    10741 atattccccc atgtcgtttt caagttcaaa aaaacctttt gctccggccc ccttagcatg
    10801 aacgacccgt tctggaattc gttcacgatc aaaatgggct agtttttcca aaagattata
    10861 gtcttgcatt aatacgggac cacgagctcc tgccgtttgg gaatgttcat tgttagccca
    10921 tggttggccg gtttccgtcg ttaatttttc cgtcatttta atcgcccttt tcacgtaaat
    10981 tacaagaaag ctcttgcaca atttaaacgc taacacctta acagagtgac ttcaatcatt
    11041 atgcacagtt aagttaatcg ttcatgtggc gtagtttaat tttaatcagc tatcaagctg
    11101 tttgatattt tctaggccac ccggaatcgt cacatgagaa atagtagcga cccatttatt
    11161 aaataatgtg ttatatttgt ctatcattat cgataattgt aaaatgataa ttataagaag
    11221 taatcattta tgaatcggct taaatattcg tgtaattcta ttattgtatt taagcgggtt
    11281 aataagtcta ggagggattt tatgcattgg ttatgggttt tgatcattgg tgctattatt
    11341 ggtgcaattg caggtgctat tactaataaa ggtaaatcga tggggtggat tagtaatatt
    11401 attgccggat tggttggatc tgcaattggg gaagctcttt tgggatcatg gggaccacaa
    11461 ttagccggaa tggcaattgt tccttcaatt attggtggtg tgattgttgt tgcgataacc
    11521 tcatttgttc tgacacggat ggattagtaa ggagatgatt gcgatgatta aaagcatttt
    11581 aaagttttgt ttagctgcaa ccttaatcgt aagtggtgtt cttattggtg ggaccgtact
    11641 tactgctaag ggaattgata acttgggtga taaattacaa gataagttac atggataaaa
    11701 attaatttta caatgagcca ctgatgggtg tactagttga cctgttagtg gcttttagta
    11761 tgagtaatat cattgagttc aaggaactaa atcaagagcg acgattttaa actaccttca
    11821 atcgaataaa agtaatattt acttttatta agaatgaggg tatgattaaa atcaaaaaaa
    11881 gaggattgtc ctatgtctaa acttattgcg aaaaatgttt ttcagttgcc aaaaatgaat
    11941 ttattagtgc tgactacatc ggctttctta ttagccttag acgttatttt atacaaaatt
    12001 gctatcggac cagcgtattt tcaattatct tttggctttt tgtctatggc ttgtattggt
    12061 tatctatatg gtcccatttg gggtggtctc ttggagatga tctccgatat attaagcttt
    12121 actatttttg gttccggcgc gtttcagatt gcctttttgt taactgcatt tttaggggga
    12181 tttattgacg gtttgttttt atatcgtaaa tcagtcaatt ggttatccgt tgtgatgacg
    12241 caaatacttg taatgatttt tgttagtctg atgatggact catggctgat ttcagtacta
    12301 tttggcacta attttaaagt gttattgttg ggaagattgg cacgcgtcat cattcagata
    12361 ccattacagg tgattgctat tttttacttc attaaggcgt tagaaaaacg acacgttttt
    12421 gatagaatgg ggcttagata acatcgatgg atgccacaaa aagaggttga acatggtatg
    12481 aaatgcgcta caatcgttaa acaaataagt ctaacttttc tattgcactt caagtctagt
    12541 tcaacctttt ttaatattaa ctggccttat tatgactgcg gaaaaacaat ttgggtatcg
    12601 atggttgagt tggtacccag caaaataaaa gagcggctat gtggtgggca tgataattcc
    12661 cttagcagct aaattgcgga cacattctgc taagtagctg gcgttgtgtt ctggatagat
    12721 tggtgttgtt aatgcaatag gagtgaggtg atcataaggc gggcaaaact gcccacgata
    12781 atttggatca taccatattt tattaggatg atagccgcga agttgcattt catccatcac
    12841 taatacatga aattgataca acttgtaagg ggaatatttg aaaacataat taacggttgc
    12901 atgattttta ccccaaccat tgcctctcaa tgcggcaagc tcacggtgtt gacctagtaa
    12961 ttgttgtcgt ggtaattgat ggattaattg ttcatgccat agacgcatag gccacactcc
    13021 cttatcgaat tttaaaatta acaggtgaat attaaaagga ccaactcatc attatgatgc
    13081 cgaatatact gatacttttg aacgggtgat gattgtaaac gacggatagt taaagtgaat
    13141 attcgcaatt attatagcat agcgaattga tcaatagttt agtacaagat caaaaaaaac
    13201 ggccatagca acaactgata tgatcaaaca ttccttagaa tgcttacctt gaaagttggg
    13261 ttgagtaatt aaaaataaca ttattttatg ttgtgttagc agcagttcta aattttgatc
    13321 acagcggtgt ttgatagatg tttggcggta tgcaaataaa attattgttc tgataaaagg
    13381 aatcaatgat taataatctt gagcgtcatt tttcgaatca tggcgttttt atattacaat
    13441 ggtcctagaa aaagtaaagt tatggaggcg attaaatgag tgatttggat cagacaaaca
    13501 attatcgata cgtcattgtt ggtggcggaa tggttgctgg ctatgccatc aagggaattc
    13561 gacaggaaga tccagagggc gcaatcttag ttatttcgca agaggcggat gttccgtatg
    13621 aacggccggc actgagtaaa aagctatggc tagatgatga gtttactgaa gagaacattc
    13681 ggattggtgc tgaaaattat cctaatgtga cttttaagtt caagacaacg gttacggcta
    13741 ttaatcggca agataaggtt attacagtga ctgatagtga gcaaatcaaa tatgaacagc
    13801 tattgctggc aactggcgga gaacctcgac aaatccaggg acctgctgat ccacatgtgc
    13861 tagtctttag acagtggtca gattatcgca agttacgtaa atttagtggt ccgaacaagc
    13921 gagttgtgat cattggtggt ggatatgttg gtacagagct cgcatcgtca ctgactcaaa
    13981 atgggactaa agttacgatg attttcccag aaaaagcgct gggcgagggt aaatttcctg
    14041 agtccattcg ggctgagtat gaagcaacgt tcaaacgtaa tggtgtcaca ctgatgagtg
    14101 gtcagtttgt ccaatcatat caacgccaag gtgatcattt gactctattg acaaaggacg
    14161 gtacggtgat cgcagtcgat acaattattg ttgggttagg tgttacgccg cggattagtt
    14221 tggctgaaga tagtagtttg gatttagctg atggtggtgt gaaagttaat gagtatctca
    14281 atactagtga cccagccatc tggtctgctg gagatattgc ctcttatcca gatcacatct
    14341 tgggtcggca acggattgag cacgtggacc atgcccgact ttctggtgaa ttagttggcc
    14401 gtaatatggc aggtgctcac atgagctatc aacatacccc atacttctat tccatgattt
    14461 ttgatatttc ctggcaagca atcggtaata ttgatcctaa attgcaattg atttttgatc
    14521 ggcgaacgca tggaacgctt gtctatttca tagatgccgg taagttagtt ggtgttttag
    14581 tctggaatgt taaggtgaac cttgatgatg ttcgcgcatt gcttgcgaac gctccagcca
    14641 cggatgattt ggtaggttcc attagagagc aagcgggata gtatctggat gagacatttg
    14701 cgctattgtg aatatacgtc aggacaaatc gaccatcatt aacgatggtt cagtaacaaa
    14761 tgaaaagtca gccgtaagtt attttgttta cgactggctt ttatttttaa tgtctaaaat
    14821 tataaggcgc taatgaagcg ttgtgcgatt tcgagtggcc gggtgatggc gcccccgaca
    14881 acgaccgcgt ggcaccctaa gtcaaggcaa cgtttcatct tctcgggcgt atccacctta
    14941 ccttcagcga taacagggcg tgatgtggct tggaggactt cctttaagta ggcaaagtca
    15001 ttatcagcaa tgttggcacc agtcgtggct ggtgtgtagc cgtgcatcgt ggtcccaata
    15061 atatcaaagc ctaacttatc cgctactttg acgttctcga tggtatcagt atcagccatc
    15121 aagagggtat cagggaattc tgttcgcatg gtggtcacaa tctccgccaa tttctcaccg
    15181 ttagggcgcg gctgacccgt gacatcgcag gcaactacgg cacagcctgt agcagcaacg
    15241 ccccgcatct ctttgattgt tggcgtgatg taaacaggtg agtcgggata gtcgactttg
    15301 cttaaaccaa tgagcggtag atcaacttcg tcttgaatgg cctgaatatc aacaacggaa
    15361 ttagcgcgaa tacccgcggc cccagcttcc ttagcggcaa gggccattcg tgacataata
    15421 aatgaactat gcagtggttc attgggtaac gcctgacacg agataattaa tgatccctta
    15481 actgtattta agaatgtatt tttcattgga tagtctctcc ccgtattatt tgtacttatg
    15541 ataacgttat cataaattga gtgggacgta tatgacaagg ctaatctttt agtggtggaa
    15601 ttccgctagt aattagcgtg tattgaccag agcacgttta tttatcagca caatttataa
    15661 atataaaatt aatgctaata aattaggagc gctagtatct gaattgatag agtcagaact
    15721 aattatatga ttaattgtgt ttgttataat agtaatagca aatataattg ctgactgacg
    15781 aaatggcgtg ggataattgg cttaatgata gcaataatat tagcgctttg gttcggtggt
    15841 taagagcaac atgaagattc agacctgagt ttgaataaat aaataggtag tactgagtgg
    15901 agtagtgtat ggaaaataaa tatcaaaaag tcaaagatgc cctgaaagaa gccattcttt
    15961 cgggagaata tgcaattgat gcaaaattac ctacggagac ggaaatgatg aaacgttttg
    16021 ccgtctcaag atatacgatt cgacgagctg taggagacct tgaaacggag catttcattt
    16081 atcgtattca aggcggggga atgtttgttc aagattggca taaggactgg tcgagtgaac
    16141 atgacagtaa aattattggt gtgattgcga cacatgttgc agattatatc tttccgcaaa
    16201 ttatttatgg gattgatcaa gttatttcgg agggtggtta ctcgttgcta cttggcaata
    16261 cgcataataa tcatcaacgt gaacgtaaaa atttgatcaa tatgctcaat agcaaggttg
    16321 cggggctaat cattgaacca actcagagtg ctttggacaa tcctaatatg gacttgtatc
    16381 aggaaattaa ggataatggt attcccgtgt tattcattaa tgcaagttat cctaatttgg
    16441 actttcaagc cgtcacaacc agtgatcaag aggccgaaca gcggatgatt gaatatttgt
    16501 ttgaaatggg tcatgagagc attctgggta tttttcaggt gga
//
