LOCUS       gnlProkkaIGJFBCHL_27   14628 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IGJFBCHL_27.
ACCESSION   gnlProkkaIGJFBCHL_27
VERSION     gnlProkkaIGJFBCHL_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 08:47:45
            Original ID  :: gnl|Prokka|IGJFBCHL_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14628
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14628
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4217:4628]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4218..4628
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14628
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14628
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..127)
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="MADGFFHVFGGAVLGVEVFYGVTVGYDVATESHFATQAGGEP"
     CDS             complement(416..997)
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MPYGLGEGHCQLSTGVVVAEEDVGQGRSAFGAGIPGFEDGGDELV
                     CPVDGERASVDEYQYDGLARGLYGLKQLQLPAGQVEAGARFVFAAGALSTAQYYDGNIS
                     LAGIFYGFVYLGLLVVGQRIVYDFTFGPVGIYQVAAFGVEHLCLAFCLFLNAFQYSGHL
                     YGKGAVMGQRVAFFVGIGTTDGNLLGGVDV"
     CDS             complement(1112..1510)
                     /locus_tag="ctg27_3"
                     /transl_table=11
                     /translation="MGFNGFGTGLVVFYGQRSVQADVFGRGAGHEHEVAGFHHPFHVSV
                     QKLQVLAVDGEGQLLGFARFEVDALEACKILFVGGDAAQYVADIELHYFISGTFAGVGH
                     LQADGGRLVRGDDSGGDVEVGVLEGGVA"
     CDS             1526..1861
                     /locus_tag="ctg27_4"
                     /transl_table=11
                     /translation="MSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKVDKVAI
                     AFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRV
                     SIAEVKF"
     CDS             complement(2497..2910)
                     /locus_tag="ctg27_5"
                     /transl_table=11
                     /translation="MDAGGLITYLCQGPIFGIHGKDGDAVFFQTVAGVEVFPIRTEVDV
                     CTSTGGYGVGCDSLYLFQAAVVVTEGNDLTGQFGDEIGKLPVRAECQMARAGICLNANG
                     FQRSMRNRVVGVHHKAQDAVGTEVGGEDILSVR"
     CDS             complement(3275..4045)
                     /locus_tag="ctg27_6"
                     /transl_table=11
                     /translation="MCLARKVIGYTVHFLFAFLGGRYIGTFEVGDADIIRFTGKVIIGH
                     HSQLSGKTESHLIFHLFRRQPDGECLGFFLYFAREHFRHSRFLLVQIVKHQLELGAVLG
                     HIVCFAAQEGILAFADAVYFLSHQLGHLGTGVGHQYFFRQKTAWVNAAFGGFGFGRLGS
                     RLTAERNVDGADNSVFGKLHKGCYGLVFHLHEIDVVLIRYTGYAGFYLIQCPELLGFGR
                     HVVETQIAVGISAKFSGSVGMLGGLQYDFYFCFG"
     CDS             complement(4218..4628)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_7"
                     /sec_met_domain="PqqD_RRE (E-value: 4.3e-10, bitscore:
                     30.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.6e-17, bitscore: 52.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVISWKSLIFRNNRKSGYRMMEIPEGKVSLLDAVPVRCGHITTEW
                     EGECAVLAYPRFKYEWMRRFLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLA
                     RHFGEEENYIPRVTAYVMQLRKDGFIQLTIRN"
     CDS             complement(4591..5922)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 98.1; E-value: 7.3e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg27_8"
                     /transl_table=11
                     /translation="MIVAFTMMAAYYVNDVVAPLKTMLETDLAWSSTDFGFFTGGYSFL
                     NVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYYAMTGLAGADATLFGINEIFG
                     YKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKELATAMGVQVALARIGSQAGYA
                     VAIPLARAFGISTPVLLGLVLLLGGMIAFFVFAVMDKKLDKQMEAAAIAAGTEDEEEKF
                     SFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELMIIKYGINENVAGTFAGLPAL
                     GALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAIPDINYWLVAIVLMIILGIAF
                     SLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIPTLIGWVLDAYCISGKKPDGT
                     NMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEEPNIQK"
     CDS             complement(6136..6378)
                     /locus_tag="ctg27_9"
                     /transl_table=11
                     /translation="MEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTN
                     PYNMPVGTEAPQSEAPAATTPAETPAPAAEAPAAE"
     CDS             complement(6530..7303)
                     /locus_tag="ctg27_10"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLRLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(7308..7760)
                     /locus_tag="ctg27_11"
                     /transl_table=11
                     /translation="MKLGLAPISSIDYTKVKTISIADFQNRAEYVYAPLATEFNQKMKD
                     MFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDASGYSSKVKVTLTVNVRYTNNTNHE
                     EDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIAEQIFNATVANW"
     CDS             complement(7819..9069)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 379.9; E-value:
                     3.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg27_12"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             complement(9071..10168)
                     /locus_tag="ctg27_13"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLPTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             complement(10174..11217)
                     /locus_tag="ctg27_14"
                     /transl_table=11
                     /translation="MFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEPGLWE
                     RPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLYTQPK
                     FKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDKHSDY
                     IATKVKSQFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTFTKEY
                     FVHKRDSVMKVNIPGAREGMYMSTDSLMTDVRPISVQGDYALEARGLWRIKGDFMGGPF
                     VSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKQEGAEIPVGVTS
                     KDTTNNK"
     CDS             complement(11300..11689)
                     /locus_tag="ctg27_15"
                     /transl_table=11
                     /translation="MQRRELMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVND
                     SLPYAKELLKLLRGLDCRINLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSS
                     RGEDIFAACGMLSTAKQEENKEELI"
     CDS             11702..12325
                     /locus_tag="ctg27_16"
                     /transl_table=11
                     /translation="MKADSQMAVRFLNKTLQALLQSHRRKCNTLGTPRIPIRGGHYFQR
                     FQYLVQIIKWFTHAHHYHIGKLVPFGQRIDLINNLVGCQIGSKTLFAGHTELAIHLTAH
                     LRGDTKRSPVFVGYIDSFHEMPLACPVQVFHRTVYRAHGIYRRFGTYLIDFFQQFPMLQ
                     RKIAHFVYRSHLLVIQPGSYLLGRETGHSQILHHILQFRERQAQ"
     CDS             complement(12494..14590)
                     /locus_tag="ctg27_17"
                     /transl_table=11
                     /translation="MIVIGLALFAFIAGDAWKVLQPHQSQDVGEVNGESISAQDFQALV
                     EEYTEVIKFSSGNSALSDEQTNQIKDEVWRTYVNNKLIEKEAKKLGLVVSKAEIQAIIN
                     AGVHPMLQQTPFRNPQTGAFDKDMLKKFLVDYSKMNKAQMPSQYAEYYESMYKFWSFLE
                     KSLIQARLQEKYQALITKSLFSNPVEAQDAFDARVEQSDLLLAAVPYSSIVDSTIVIKD
                     SDLKAAYDKKKEQFKQYVETRNIKFIDVQVTASAEDRAALQKEMEEYTEQLTANPSDYT
                     TFIRSTGSEAPYTDLFYTTKSLPADVTARLDSVAVGGVFGPYYNVSDNTLNSFKKLATA
                     AMPDSIEFRQIQVVAEDAEKTKTLADSIYNAIKGGASFAEVAKKYGQTGEPTWISSANY
                     EGAQIDGDNLKYITAVTTLGQNELTNLALGQANVILQVTNKKAVKDKYKVAVIKRPVEF
                     SKETYSKAYNEFSQFIAANNTLEKMIANAEDAGYKLLDRADLYSSEHGIGGIRGTKDAL
                     KWAFEAKAGEVSGLYECGESDRMLVVGVASIVPEGYRPLALVKDQLRAEILRDKKAEKI
                     MADMKAANATSFEQYKNMANAVSDSVKHVTFSAPAYIPALRSSEPLVGAYASIAEVNKL
                     SAPIKGNGGVFVLQPYAKEKLNETFNKETEEANLANMHARMASQFISDLYLKANVKDQR
                     YLFF"
ORIGIN
        1 ctggctcacc acccgcctgc gtggcgaaat gggattccgt ggctacgtcg tatccgacag
       61 tgacgccgta gaatacctct acaccaagca cggcaccgcc aaagacatga aagaagccgt
      121 ccgccaaagc gtggaagccg ggctgaacgt acgctgtacc ttccgctcgc ccgactcctt
      181 tgtccttccc ctccgcgaac tggtgaagga aggcgggctg agcgaagaag tcattaacga
      241 ccgtgtgcgc gacatcctcc gggtaaagtt cctcattggt ctgttcgatg ccccctacca
      301 gacagacctt gccggtgccg accgtgaagt ggaaaaagaa gagaacgaag ccatcgcctt
      361 gcaggcatcc cgcgagtccg tcgttctgct gaagaatgcc ggtgagctgt tgcccttaga
      421 catcaactcc accaagaaga ttgccgtctg tggtcccaat gccaacgaag aaggctacgc
      481 gctgacccat tacggccccc ttgccgtaga ggtgaccact gtactggaag gcattcaaga
      541 aaagacaaaa ggcaaggcag aggtgctcta caccaaaggc tgcgacctgg tagatgccca
      601 ctggcccgaa agtgaaatca tagactatcc tctgaccgac gacgagcaag ccgagataga
      661 caaagccgta gaaaatgccc gccaagctga tgttgccgtc gtagtattgg gcggtggaca
      721 acgcacctgc ggcgaaaaca aatcgcgcac cagcctcgac ctgcccggcc ggcagttgca
      781 actgcttcaa gccatacaag ccacgggcaa gcccgtcgta ctgatactca tcaacggacg
      841 cccgctctcc atcaactggg cagacaagtt cgtccccgcc atcctcgaag cctggtatcc
      901 cggctccaaa ggcggaacgg ccctggccga catcctcttc ggcgactaca accccggtgg
      961 aaagctgaca gtgaccttcc ccaagaccgt agggcaaatc cccttcaact tcccctgcaa
     1021 gccttcttca cagatagacg gcggtaagaa tccggggccc acgggcaaca tgtcacgcat
     1081 caacggagca ctgtacccct tcggttacgg cttaagctac accaccttcg agtactccga
     1141 cctcgacatc cccccccgag tcatcacccc gaacgagtct gccaccgtcc gcctgaaggt
     1201 gaccaacacc ggcaaacgtg ccggagatga agtagtgcag ctctatatcc gcgacgtact
     1261 gagcagcatc accacctacg aaaagaatct tgcaggcttc cagcgcatcc acctcgaacc
     1321 gggcgaagcc caggagctgt ccttcaccat cgaccgcaag cacctggagc ttctggacgc
     1381 tgacatgaaa tgggtggtgg aacccggcga cttcgtgctc atggccggcg cctcttccga
     1441 agacatccgc ctgaacggaa cgctgaccgt agaagactac cagacccgtg ccaaagccat
     1501 tgaagcccaa aaaccagcaa agcgtgtgag tgccagcacc aacccagagg atgccgaaaa
     1561 cgtgctcgac gaaaaaatca ataccgcatg gcaaggaaat aagggagatt atattacctt
     1621 tgccttaaag aacggagcca aggtagataa agttgccatt gcctttacac gtgacaacaa
     1681 cctgccggca accttcgaaa tccagctctc gggcggtggc ggacagttcc tcaccgtata
     1741 ttcgggcacc gtcagcgaat acggcaaact gatttcctat ccgttcaaag gcactaccgc
     1801 cagcgacctc cgcatcgtgc tgaacgatga ccgcgtcagt attgccgaag ttaaatttta
     1861 atgtgctaat gtgccaatat gctaatgtac caatgaccat gcagcatata cagcgcagcc
     1921 aattagcaca ttagcatatt ggcacattaa cacattaaat taatgaaaac acttcttttc
     1981 tgtatgctcg gattaggttt gacagcatgt ggctcttctc caaagggcac taacggtgac
     2041 caggacgaac tcgccatgct aataggtact tacacgaatg gctcaagcaa gggtatctat
     2101 accttccgct ttaatcagga gacgggaaca gccgttccgc tcagttcagc ggcattgccc
     2161 aatccctcct acctcgtccc ctcggaagat ggcgaatttg tctatgccgt cagtgaaatg
     2221 aacgacagca cagcagccct cagctccctt gccttcgacc gggaaacggg agaactgcgc
     2281 ctgctgaaca ccgttcccac cttcggcgcc gacccctgct acgtggccac caatggccgg
     2341 gaagtgttga ctgccaacta cagcggtgga accatgtccg tctttccttt acagaaagac
     2401 ggcactttgg ctcctgcaga cacgctcttt caaggctctg ccaccggtcc cgacgccata
     2461 cggcaagcca ctccccacat ccattgcacg gtcttttcac cggacggaaa gtatatcttc
     2521 gccaccgact tcagtgccga ccgcatcctg cgctttgtga tgcaccccga caaccctatt
     2581 cctcatgctt ctctggaagc cgttggcatt gaggcagatt ccggcccgcg ccatctgaca
     2641 ttcagcccta acgggaagtt tgcctatctc atcaccgaac tgtccggtaa ggtcattgcc
     2701 ttcagttacg acgacggctg cctggaacag atacagacta tcacagccga caccgtagcc
     2761 gcccgtggaa gtgcagacat ccacctcagt ccggatggga aatacctcta cgccagcaac
     2821 cgtctgaaag aagacggcat cgccatcttt gccgtgaatc ccgaaaatgg gaccttggca
     2881 aaggtaggtt atcagcccac cggcatccat ccccgcaact tcaacatcac gcccaacggt
     2941 aaatacttgc ttgccgcctg ccgcgacagc aatgtcattc aggtatacaa acgaaacgaa
     3001 gttaccggac tcttggaaga tactcatcag gacattgtag tcgacatgcc ggtttgcgta
     3061 cagttcgtca gctctgttaa taatttataa agcaatattt agcaaagata acttcattaa
     3121 ctttgtccct tagctaaatc agtctaaacg aatgtacatt atgaagaaga atatattgat
     3181 gctctcagct ctgttcttgt ctatcactgc catggcgcaa acagacgtaa ccaccggtgt
     3241 gatgcgtggc aaagactacg gagtgactta tatgttaccc aaaacagaaa tagaaatcgt
     3301 attgcaagcc accaagcata cctacactcc cggagaattt tgcagatatg ccgaccgcta
     3361 tctgcgtctc aacaacgtgt ctgccgaacc cgaggagttc tggacactgg ataagataga
     3421 aacccgcata gccggtgtac cggataagga caacgtctat ttcgtgaaga tgaaagacaa
     3481 gaccgtagca ccccttatgg agcttaccga agacggaatt gtccgctcca tcaacattcc
     3541 gttcagcggt aagcctgctg ccaagacgcc cgaagccaaa gccaccgaaa gcagcattga
     3601 cccacgcagt tttctgacgg aagaaatact gatgtccaac tccagtgcca agatggccga
     3661 gctggtggct aaggaaatat acagcatccg cgaaagcaag aatgccctcc tgcgcggcga
     3721 agcagacaat atgcccaagg acggcgccca actcaagctg atgcttgaca atctgaacca
     3781 gcaggaaacg gctatgacgg aaatgttctc gggcaaaata aagaaagaac ccaagacatt
     3841 caccatccgg ctgacgccta aagagatgaa agatgaggtg gctttccgtt tttcccgaaa
     3901 gctgggagtg gtggccaata atgaccttgc cggtgaaccg tattatatca gcgtcaccga
     3961 cctcaaaagt cccgatgtat ctgccaccga ggaaggcaaa aagaaagtgg acggtgtagc
     4021 ctataacctt ccgggcaagg cacaagtgac attgatgtat aacaataaga aattgtttga
     4081 cgaccaactt cccattaccc aattcggcac cgtagaatac ctcgcaccgg tactgttcaa
     4141 caagaattct accatcaaag tgctgtttga tacggcaacg ggaggattga taaaagtgga
     4201 tagggaataa aggaattcta attccggatt gtcaactgga taaatccatc cttacgcaac
     4261 tgcattacgt aggcggtgac ccggggaata taattctctt cctccccaaa gtgcctggca
     4321 agtagagaga tgatttcgcg cacggtacga tgtccatcta tcagattcca gacagctgta
     4381 ccgtgttctt ccagcctcac atggatgtca ggagacatcc ccttcggcaa taaaaaacga
     4441 cgcatccatt cgtatttaaa ccgtgggtag gcgagtacgg cgcactcacc ttcccattcg
     4501 gttgttatat gtccacagcg gaccggaaca gcgtccaaca gacttacttt tccttcgggt
     4561 atttccatca tacggtatcc gcttttccta ttatttctga atattaggct cttccagctt
     4621 ataaccatac ttcttgtctg ccttcttcag cagtagagcc actataaggg acaagcaggc
     4681 aataccggta aaaatgcaca taggcaccgt atagtcatac atattcgttc catctggttt
     4741 cttgccggat atacaatagg catcaagcac ccaccctatc aatgtaggaa taccccaaag
     4801 accgatattc tggataaaga aaatcaatgc gtatgccgta cccaactggc ttaccgggaa
     4861 tatcttggcc acagccggcc acatggcaga aggtaccagc gagaaagcga tacccaaaat
     4921 tatcatcagc acaatagcta ccagccaata gtttatatcg ggaatagcat aaatgaaatg
     4981 cacacatatc agcatggccg agcccagcag catgatagat gcggacttgc cccgcttgtc
     5041 aatgaaacca ccaaagaccg gagtcagaat cagcgctccc aatgccggaa gtccggcaaa
     5101 tgtaccggcc acattctcat tgataccgta tttgataatc atcaactcgg aagcaaactt
     5161 ctggaatggg aatacacaag agtagaacaa tacacacagc aatgctatca gccagaaacc
     5221 gggattgacc agaatattct tcacatcctt aaaagagaac ttctcttcct catcttccgt
     5281 accggcagca atggcagcag cttccatctg tttgtccagc ttcttgtcca tcactgcaaa
     5341 gacgaagaaa gcaatcatac cgcccaacaa cagaaccaaa cccaacaaca ccggtgtgga
     5401 aataccgaaa gcacgggcca aaggaatggc tacggcataa ccggcttgcg aaccgatacg
     5461 tgctaaagca acttgtaccc ccatagccgt ggcaagctct ttccccttaa accacttggc
     5521 tatgattttg gaaactgtaa taccggcgac ctccgctcct actccaaaaa tggaataacc
     5581 ggcaaaagca acaaacacac ccgttttata gccaaatatt tcattgattc cgaataaagt
     5641 cgcgtcggca ccggcaagtc ccgtcattgc atagtattca agtgctgtac cacctaccat
     5701 caggatagtt gccagctttc cggtgaaacg gataccaaag cggtcgagga ttaatcctcc
     5761 ccaaatcaac atcaggaaaa aaacattcag aaaactataa ccaccggtaa agaatccgaa
     5821 atcggtactc gaccaagcca agtccgtttc caacattgtc ttcaacggtg ctaccacgtc
     5881 gtttacataa taagctgcca tcatcgtgaa ggcaacaatc accaatgccc cccaacgggt
     5941 agccttggaa tcattcaatt taagtttgag ttgttctgtc attgtactat ttggatttca
     6001 atttattaat cagattgcat aaattgctga caaaggtaaa taaatacttc atcaaaacga
     6061 aaaaaggctg acaccttttc agtatcaacc tttctcttat ttttccaagc gggagtcatc
     6121 cgcaatatcc ttatcttatt ctgctgcagg ggcttctgct gcaggagcag gagtttcagc
     6181 cggagttgta gctgcagggg cctccgattg cggagcttct gtacctacgg gcatgttata
     6241 aggattagtt ttttcttctt gttgcgcctg ttccagaatc acatcaccgc ccttgcctgt
     6301 ggaagaagga atagtgtaag cagaaacaat actgaagact accatgacag ctgccagagt
     6361 ccaggttgct ttttccaaaa agtccgtagt cttgcgcaca cccataattt ggttggatga
     6421 tgaaaagcct gatgccagac cacctccttt agaattttga atcaatacaa tgaagcacat
     6481 cagcacagat gcaatcagca ttaagataac taataataaa tacattttgt tattttgatt
     6541 tagcgttaat aatcaatttc tccaaaaatc tgatttggtc tgcaaagtaa gcattttttt
     6601 ttggataatt caatcttaat tttttaataa tttcaagcgc cttgtcatat cggtgctgtt
     6661 ttatatagat tttggctaaa gtttccgtaa aacagctatc gtccaactct tccgttaccg
     6721 gcgatactga gggttcttcc tcttcttcag tctcttcctc cttctctaca agaaactccc
     6781 ttctcgtatc cgaggcatcc gaagactcac tcttttggat aaagtcatct atcaattcat
     6841 gcccacgcag tttaggcact tccgactcat cttctgcatc cacaccgggt tcttcctgca
     6901 ttaaataggc cgtataatcc accgcataat ccagctccgt atgctgtgaa tgctcttcgg
     6961 gaacagtagc cagaaatgcg tcaatcaagg aaagggtacg gtccacactc ggctctttct
     7021 ccaaatcgcc ggaaaacagc gacgagacct tccgggattt caaagtatag cggtcaccct
     7081 ctataaagta aaacagcaca cgacggtctg ccacatacaa cacagccttg cgcaactccg
     7141 cgccaaagtt gatgtcgtgc agtagataga ggtttttcag atagagcaaa cggagcgact
     7201 ggaaataagg atagcgtgcc accaatgtgc gaagctcgta caaagtatcc ctattcagcg
     7261 tctcgggatg ctgaatccat tgttgcaaat gggtaggcgt catgagttta ccagttagct
     7321 acagttgcat tgaaaatctg ttcggcaatg tctttcacca tcaaggttat cagctggtcc
     7381 tgcacttcgg tcagcaattt tgaggaatca taggtctgga aagccgagaa ctgctgttca
     7441 aagtcctcct catggttcgt gttattggtg tagcgcacgt tgacagtcag cgtcaccttc
     7501 accttcgaag agtagccgct ggcatccacc gattcattat attgattgta gccggttatt
     7561 tctccgtcta tttccaggtc tcctccggaa ttcaccagtt gcaggcgagt ctgctgaatg
     7621 aacatatcct tcattttctg gttaaattct gttgccagcg gtgcatatac atactctgcc
     7681 cggttctgga aatcggcaat ggaaatcgtt tttacctttg tatagtcgat agagcttatc
     7741 ggagcaagtc ccaacttcat actacatgaa ttcaccagaa ataacaagct taccaacaag
     7801 gaagcaaatg ccgctttttt aatccaatcc atattctttt atctttctgt ataacgtacg
     7861 ctcagagata ttcaaatcct gagccgcact cttacgcttg ccgtgatgtt tttcaagcgc
     7921 cttacgtatc atttctttct ccacttcatc cagggagagt gactcctcca catattcttc
     7981 cgtatcctgg aaatcatcgt ccaccggagt aaccggcttt accgaaggat gtataatggt
     8041 ggggacactg gatgttaccg gaggtaccac cgccggagta gccggcgtat agtaggccga
     8101 tgtggcaacc gccggattgg ctaccgttcc cctttcagcc ataatctcat gcaccaactt
     8161 tttcaagtcc gttacatcct ggcgcatatc aaacagaacc tggtagagaa tttcccgttc
     8221 actcccaaag ctcttgtcct ccttcactcc aaacaaggca ggcaggcgct gcatattgtt
     8281 ctgctcaggc agatagccct tcagtatgga tgcattgatt tcacgattgg tctcaatgat
     8341 ggatatctgc tcggtgatat tcttcaactg gcgcacatta cccggccatg agtagcccag
     8401 caacacttgc ttgccgtctt ccgtcagctg aatggcaggc atacggtact tttctgcaaa
     8461 gtccgaagca aactttcgga acagcagcac cacgtcttca ccgcgttcgc gcaatggagg
     8521 gacctgaata ggaactgtgt tcaaacggta atacaagtct tcacgaaaac gtccgtcagc
     8581 aatggcttgt gtcaagttta cattggtagc ggcaacaata cgcacatcgg tcttttccac
     8641 cttagaagaa cctactttga tgaattcacc gctctcgagc acacgcaaca agcgtgcctg
     8701 ggtaggcaaa ggcaattcgc cgacttcatc aaggaagatt gttccgccgt tggcctcacc
     8761 gaaatacccc ttccgttcgc cgatagcccc ggtaaatgcg cccttctcat gaccgaacag
     8821 ttccgagtca atcgtccctt cgggaatggc tccacagttc acggcaatgt actgtccatg
     8881 cttgcgccgg ctgtactggt gtattatctg cggaaagctc tcctttccca caccactctc
     8941 tccggtaatc agtacagaca agtcggtggg cgctacctgg atagcgatat caatggcacg
     9001 catcagcgct tcattgttgc cgataatgcc gaaacgtaat tttacttgtt gtatttccgc
     9061 ttttgtcatt ctacaaatct tcttctacac tatcgagttt cagtttgtcg ctatcgtcac
     9121 gtttctcgta atattgcttg cgcagcggat ttgcatgtgc ctctttctca cgctggcggt
     9181 tacggaacac atctattgcc acatagatag cctgccggaa tgaatcttca gaggcgattc
     9241 ctttcccggc aatatcgtag gccgtgccat gagcaggcga agtgcgtatc accggcaagc
     9301 cggcagtata gttcacgccc tcgtccatag ccaatgcctt gaacggtgcc agcccctggt
     9361 cgtgatacat ggccaggata ccatcaaaat gggtaaagtt atctgagccc ataaacccgt
     9421 ctgccggata aggaccatag caaagcatac ccttagcagc catttcgttg atggccggaa
     9481 tgataatctc ctgctcttca gttcccagca atccgccgtc tcctgcatgc ggattcagcg
     9541 aaagcactgc aatacgcggt gcgctgatag caaaatcctg cttcaaggag cggttgaata
     9601 tcttcagttt ttcttgtatc agttctttgg tgatgcttcc ggctatctct ttaacgggaa
     9661 tatgtccggt caccaatgct acccggaagt catctttcat cagaatcata agggccttct
     9721 cgccatctcc caatttttgc tctatatact ccgtatgtcc ggggaaggca aactcctccg
     9781 actggatggt atgcttgttg atgggagctg tgacaatcac gtctatcatt ccctccttat
     9841 attcctcaat ggctttttcc agtgcaccaa gtgcagcttt accagcttca acgtcaggtt
     9901 tagagaactc aacctttact tcatcatccg tacagttcac tacactcaag cgattgggaa
     9961 ccgcttcgga ggcggagttg acgatactga agttggtagg caagtccaat gatttacgat
    10021 gataagctgc cactttaggc gaaccgtaga taatcggcgt gcacaattcc agcatcaccg
    10081 ggtctgcaaa cgtctttaaa atcacttcat accctacacc attaatgtcg ccttgtgtaa
    10141 tgccgactct tattttgttg tcttccattt ttattactta ttattagtag tatcttttga
    10201 ggttacgcct accggaattt ccgcaccttc ctgcttgctg ccgggcagtt tcaaggtata
    10261 gagcgaagcc tccatctgac gtaccagatt acgtttcatt ttatcaggtg aataaataaa
    10321 tatttcagat acgataatac gctgattggc cttgtccaaa cgtacatgcg atacgaacgg
    10381 accgcccatg aagtcaccct ttatgcgcca caagccgcgg gcctccagtg catagtctcc
    10441 ctgcacactg atggggcgta catcggtcat cagagaatcc gtcgacatat acatgccttc
    10501 acgggcacca gggatattaa ccttcatcac ggaatcgcgt ttatgaacaa aatattcttt
    10561 agtaaacgta tccttatccg tataaggata agagtagatt acaaagttct ggtcgccggt
    10621 agctgcattc gtacctgccc agaagaagtt ctcaccctcc ttggtagatg tcagttcgcc
    10681 cggcacccat acatcgcaat cgaactggct tttcaccttc gttgctatat agtcgctatg
    10741 cttgtccttc aatactgaaa tctgacgatt catttccgca tgggtaaaga aatcgatgat
    10801 tacctgccta ttctcctcca caaatttctc gaacgaagcc tcgtccggtg cctgaatagt
    10861 gagaatagac tgaggagcag catatacatt ccttgcatac ttgaatttag gctgggtata
    10921 gaggtccttg ttcacatcga caataatgat attacgaatc agttttaaag tggcatcata
    10981 attggaaggg gcagtataca tgattcggaa tgaacgttct gactggggaa gccccggaac
    11041 atcagaatca agcacatcga aaagcgccct accggcagga cgttcccaca agccgggctc
    11101 caccactacc agaacttcat acgcacgacc actggaggtc ggagtaaaca cacccttttt
    11161 accaccaccg caagcggaaa aaagtgtcag tacgagaacc atacttaaat aaaacaagtg
    11221 ctttctcata tctctatcat tttagttttt cacaaagcta cgaagaatgc gtaatatcct
    11281 ccctacctaa gttaataatt tatattaatt cttctttatt ctcctcctgc ttggcagtgg
    11341 acaacatgcc acaagcggca aatatatcct ctccacgcga tgaccgtata gtggtaaaca
    11401 gaccgtgcga agtcagataa tcacggaacg cagtcatggt ttccatatca gccccttcaa
    11461 gattcactcc aggtatggca tgaaaacgaa tcaggttaat ccggcagtcc agcccacgta
    11521 gcaacttcag aagttccttt gcatacggta acgagtcatt cactcctttg aaaacaatat
    11581 attcaaaaga tagtctgcgc tgtttgctaa aatcatagtt tcttaacaat tcaacaatct
    11641 ccgtgatgga gaaggccttc tctgccggca tcagctcgcg acgttgcaaa ggtatcggcg
    11701 aatgaaggct gatagccaga tggcagtccg attcctcaat aaaacgctgc aagcccttct
    11761 tcaatcccac agaagaaagt gtaacacgct tgggactcca cgcataccca taagaggcgg
    11821 tcattatttc cagcgctttc aatacctcgt ccagattatc aagtggttca cccatgccca
    11881 tcattaccac attggtaagc ttgtcccttt cgggcaacga attgatttga ttaataatct
    11941 ggttggatgt cagattggca gtaaaacctt gtttgccggt catacagaac ttgcaattca
    12001 tcttacagcc cacctgcgag gagacacaaa gcgtagccct gtcttcgtcg ggtatataga
    12061 cagcttccac gaaatgcccc tcgcctgccc ggtacaagta tttcaccgta ccgtctacag
    12121 agcgcatggc atctaccggc gcttcggcac ctacctcata gatttctttc agcaattccc
    12181 gatgcttcaa cgaaagattg ctcatttcgt ctatagaagt caccttcttg tcatacagcc
    12241 aggaagctat ctgcttggca gagaaaccgg gcattcccag attcttcacc acattctgca
    12301 attcagagag cgtcaagccc aatagaggtc gtttctgcat atcgtttttc attaaaaaca
    12361 aaactctttc aagaatgcaa aggtaggaat aaagttgcac aaagacaacg gagagtatag
    12421 aaaatgaaat gtacagagaa tgaaaaagcc gcccgggagt accgaacggc ttttcaatat
    12481 gggttttcta ttcttagaag aataaataac gttggtcttt tacgttggct ttcagataca
    12541 agtcactgat gaactggctt gccatgcgtg cgtgcatgtt agccaagtta gcctcttcag
    12601 tttccttgtt gaatgtttcg ttcagcttct cttttgcata aggttgcaga acgaatacac
    12661 caccgttacc cttgatagga gcactcagct tgttcacttc ggcaatagaa gcgtatgcgc
    12721 ctaccagagg ttcgctgcta cgcaatgccg ggatataggc aggagcagag aaagtaacgt
    12781 gctttacaga atcactaaca gcatttgcca tattcttgta ctgctcgaac gaagttgcat
    12841 tggcagcctt catatcagcc ataatcttct ctgctttctt gtcacggaga atttcagctc
    12901 tcaactggtc ctttaccaaa gccagtgggc gataaccttc aggaacaata cttgcaacac
    12961 ctactaccag catacggtcg ctctcgccac attcgtacaa accggaaact tcaccggctt
    13021 ttgcctcaaa cgcccatttc aaagcatctt tggttcctct gataccaccg ataccatgtt
    13081 cagagctgta caagtcggct ctatccagca acttgtaacc ggcatcttcc gcattggcaa
    13141 tcattttctc taaagtattg tttgcagcga tgaactggct aaactcattg tatgccttgc
    13201 tgtaagtttc cttgctgaat tctaccggac gcttgataac ggctacctta tatttatcct
    13261 tgacagcctt cttgttggtt acttgcaaaa tgacatttgc ttgtcccaac gccagattgg
    13321 tcagttcgtt ctgtcccaaa gttgtgacag cggtaatgta tttcaagttg tcaccgtcaa
    13381 tctgtgcgcc ttcgtagtta gcagaagaaa tccaggtagg ttcaccggtc tgaccgtact
    13441 tcttcgcaac ttcagcaaag ctggcaccac ccttaatagc attgtagatg ctgtcggcca
    13501 aagtcttcgt cttttcagca tcttcggcaa ctacctgaat ctgacggaac tcgatagagt
    13561 ccggcatggc agcagtagcc aatttcttga aagagttgag ggtattgtca gatacgttat
    13621 aataaggccc gaacacacca cccaccgcaa cagagtccaa acgggctgtc acatcagcag
    13681 gcagagactt agtagtgtag aacaagtctg tataaggagc ttcggaaccg gtagaacgga
    13741 tgaaggtagt atagtcagaa ggattggcag taagttgttc ggtgtattct tccatttcct
    13801 tctggagagc agctctgtct tctgcacttg cagtaacttg cacatcaatg aacttgatat
    13861 tgcgagtttc cacatattgc ttgaactgtt ctttcttctt gtcgtatgca gctttcaaat
    13921 cggaatcctt gataacgatg gtagagtcaa cgatagaaga atagggaact gcagcaagca
    13981 gcaggtctga ctgctctact cttgcatcaa aagcgtcctg agcttctacc gggttggaga
    14041 aaagagattt tgtaatcaaa gcctgatact tctcctgaag acgtgcctgg ataagagact
    14101 tttcgaggaa agaccagaac ttgtacatgg attcatagta ttctgcatat tgtgaaggca
    14161 tctgcgcctt attcattttt gaatagtcca ccaagaactt cttcaacata tccttatcaa
    14221 acgcaccggt ctgaggatta cggaacggag tctgttgcag catcggatgc acaccggcat
    14281 taatgatagc ctgaatctca gccttcgata caaccagacc gagtttcttt gcttcctttt
    14341 caatcagctt attattgacg tatgttctcc atacttcatc tttgatttgg tttgtctgct
    14401 catcgctcaa tgcactgttg ccactggaga acttgatgac ttctgtatat tcttctacca
    14461 atgcttgaaa atcctgagcg gaaattgatt ccccgttcac ttcacctacg tcttgtgact
    14521 ggtgtggctg aagcactttc cacgcgtcac ctgcgatgaa agcaaacagc gccaaaccaa
    14581 taacaatcac caataaaggt cctttagacc gaatgttttg taatgttg
//
