LOCUS       gnlProkkaBDAPNGAK_307  17454 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BDAPNGAK_307.
ACCESSION   gnlProkkaBDAPNGAK_307
VERSION     gnlProkkaBDAPNGAK_307
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:57:44
            Original ID  :: gnl|Prokka|BDAPNGAK_307
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17454
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17454
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7452:8007]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7453..8007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..17454
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17454
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(194..505)
                     /locus_tag="ctg307_1"
                     /transl_table=11
                     /translation="MPDADRAFYCCCKCTQEGEKNKWIGKNGISGERIKEAIGEIERYR
                     KDMITEHCTGYEADIEACTSLIEELSEWYGQVEGQRKNTGEIEALEGDKMEEGSTGEA"
     CDS             complement(572..2206)
                     /locus_tag="ctg307_2"
                     /transl_table=11
                     /translation="MGTTAKKVSVIPAKVQFDTSIKLSDKMLKVAAYCRVSTDEEEQDS
                     SYEAQVEYYTNKIQDNPNWKFAGIYADDGKSGTNTKKRADFKTMVKDALNGKIDMILTK
                     SVSRFARNTVDSLVTIRELKAKNIAIVFEKEGVNTLEGTGEILITILSSLAQEESRNIS
                     ENVRWGIARKFEKGKVIVNCAKFMGYTKNENGDLIIVPEEAEIVKLIYRLYLEGYSSVK
                     IKKYLEDKKIKTATGQERWHTTVIDNMLCNEKYMGDALLQKTYTVDFMTKKRVVNNGIV
                     PQYYVENDHEAIIPKEIYYRVQEERMRRANLCKAAVTRKKNQKSKYSSLYALTGIVICG
                     KCGHEYRRVTWSRNGQKKIVWRCSNRLTNGVKKCPNSETIKEEALNRAVMEAIHRITCD
                     DREFIETFRQNVISVINTKEALQEENDYDTLLKNKQEEMLALIMENAKAGEYTQEFDAR
                     YHAIAEEIQSIKKNQTETRKREETLRECNQRMYEIDDFLRTTTCRIPEFDNDLVRRLIS
                     TVKIISEEKLMIQFKSGIVVEQEIRYD"
     CDS             complement(2190..3116)
                     /locus_tag="ctg307_3"
                     /transl_table=11
                     /translation="MQCHMPIGYKVEEGRIIICEEARKIVKQIFTEYDCGIAATKIAAG
                     LKEKGIPNGNGKVSWTHVSIGRILENSNYLGNEYYPQIIEKDLFNRVQKRREGVRAELG
                     RANHRPGKDERILFGGAVWCGECGTMCIRIQKRHKYGTNVNWKCKGYLYKKQEKCRDRT
                     ITDDQIKQVCVDAINAAIQNQGLLYKKDPEDVISPEYRRMDRKIAEMKGKAVSEKEFIQ
                     ALYQRAEERYRTLTVKDALYKTEEIRDILAGREKIVEFDRELYKKLIRKIYLCNGNMAE
                     VEFLNGGRMKVGYTDKKPGKEANGYNS"
     CDS             complement(3088..4704)
                     /locus_tag="ctg307_4"
                     /transl_table=11
                     /translation="MTKKITVINATAGPQNVLAECKQRVCGYARVSTKSSSQATSYTAQ
                     VEYYTAKIGENPLWEFAGVYADWGITGTKTNHRDEFNMMIEDCEDGNIDMILTKSVTRF
                     ARNTVECIQAIRRLKEIGVAVYFEKEKINTLTEKGEMLLTVLASVAQGESESISSNVQW
                     AVRKRFQDGSFIVSTPPYGYQKDKNRNFVIVESEAEIVRWIYESYLNGLGTYVIARELN
                     MREIPTVRGAEEWKDTVILEILKNPVYEGNMIFQKKYTQSQFPFNRKRNYGQKAKYLVE
                     DAHPAIITHEEAEAVRNLIAYRTRSRNVEGTDYNKRYLFSSKIICEECGQKFRRQIVHK
                     DKNYEKVIWTCRRHMENKELCSTKAIREDVVQQAFLRMWNKLYTNRGALLEPLWKELTS
                     LADSRQDSEEMIQLDNEIKNLKEQSRILNQVMRNGYMDSAVFMEKSNQINWKLTECRRK
                     KLFLGRKQKRTKEIVRTEQLIHLLSGSDGLQQKFDEKLFRMTVQNIFISRDHDITFCLN
                     NGLRLTERGGMSDAMSYAHRI"
     CDS             complement(4793..4948)
                     /locus_tag="ctg307_5"
                     /transl_table=11
                     /translation="MGNGSNEIKYKLAEVLLKRMREADLLNEEEWERITVLNIQTFSPE
                     LAKVYL"
     CDS             complement(4976..5371)
                     /locus_tag="ctg307_6"
                     /transl_table=11
                     /translation="MKKEDREMIEKIMATEKVGYAYMYPMDGGARKEHYISMTPENIAN
                     YIGTYMVEAESMVFTDIADNLELNTFGCFINTCTSRKLCMELQELLFPIQCGDEEPGEV
                     LAVDRSVADKYFQQEDEAVTMAEMSMP"
     CDS             complement(6018..6443)
                     /locus_tag="ctg307_7"
                     /transl_table=11
                     /translation="MSKCIKIRIKDFYKDAVGETEYTYVTEEVYEALVNTFRKETHAEE
                     MRDLRHITVNGYVEGMTEDLIKETGISLEDMIIRQIEIEILQKAMQSLTEVQKERLHLY
                     FFKGMTTREIADKLGVSQNVVWKSIRGSINTLKKFFE"
     CDS             complement(6831..7154)
                     /locus_tag="ctg307_8"
                     /transl_table=11
                     /translation="MSNIEVGARIRELREIQNYTREGLAEKVDISAKFLYEIEMGKKGF
                     SADTLCRISKALSVSCDYIMLGEDAGSGGKEKIICVLEKLEPKQTSKIQDILKILSELC
                     EVI"
     CDS             7453..8007
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg307_9"
                     /sec_met_domain="AgrB (E-value: 4.9e-17, bitscore: 52.2,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRIKIYIKDKYGLSNYQMAQLTFVIKSTSSELSKILLMGIAFQN
                     HLKLYIFLLIIMCFLRTFSGGLHFYTYKKCLLASTTYMGIIIFFFSKILLPLYVQLLLL
                     TVCIMSCYSIGPVLSKYRTHFPRKQLYFCRNITCLNIFMYALILYIIPKNPYLTAGVWM
                     IILHSLQLFVAKIQKKGETTQ"
     CDS             8004..8117
                     /locus_tag="ctg307_10"
                     /transl_table=11
                     /translation="MIAHILVTVAAFSWIVDTSLPSIVLFGEYPYPSEGNE"
     CDS             complement(8145..9413)
                     /locus_tag="ctg307_11"
                     /transl_table=11
                     /translation="MLYHAGLMLEYIAIIVILQRIYNRKVCLNIDSVGLCLMSLTIVEL
                     VRYYGLSNLFTIIIYILIGIYCVRKYNDSVIGSIVSVLLLLIVIVVLQYIAIFPCSYLF
                     SNNLELQMLSTNGLVLAAAIWILPLVRIHKLHEIFMKRDTYVAIILGTVMAVILMIMLE
                     DKIGKQIHLAFFTISVPMLIVLLWGLSKWHIANEEAENSKNELSLNRTMQGKYEDLLTS
                     VRLREHGFKNHLAALLSIKYTSRSYEELVAEQERYYSKICDENKYNKLLYLKDSVVIGF
                     LYEKFRVAETMGVKIRCDIKGTFSQCVMPIYHLIDILGILIDNAVEAQESSIEIKQLKF
                     QFMEKEVAYIFNVSNPYLYVSYVEIQSWFQIDKSSKGKHRGLGLYNVKELCEKYDANIV
                     CRNKLDDSENWVEFTLEIAKTDK"
     CDS             complement(9462..10184)
                     /locus_tag="ctg307_12"
                     /transl_table=11
                     /translation="MKKVLILEDNLTTLMNLTQIVQDVDAKNAVYPFHELKDAYQCAMD
                     RVIDLFIVDIILDRNRPGDSSGLKFVENIRKINHYEFVPIIFVTSLEDAKLYTYENLHC
                     YSFIEKPFDVERLKQLVEQCLRFEESRNISKTLYFRKDGIILAVEREDIVYAESINHIM
                     HIHTKQSDPLEIPYITLKKFLDDLDCSDFIQCSRNTIINQKYIENLDIPNQVIKLKNGY
                     GRVGIGIRFKKNLKGIDV"
     CDS             complement(10197..10856)
                     /locus_tag="ctg307_13"
                     /transl_table=11
                     /translation="MSATYNEMLKRLIEERKCLGLSQQQMARLVHITQSNYSKVEKGLH
                     RLSYEELKYLSKANIDIFYIFTGYRCAGKYVAYFQQCAYVELCCYLGIIYLLIVLNDCR
                     SNTEQWKDIVKRVKYVPLVLDCEKSSNIFLVIRHTTCSRQEPMAEKLGVDIKKFRELEK
                     DRCLPDSEIIWKLYNLFHISPAVVLKDKNSMINEISSLLEAAEENGAEIIDIIRQI"
     CDS             complement(11250..11759)
                     /locus_tag="ctg307_14"
                     /transl_table=11
                     /translation="MKFEGFACSIRIYYKFEWKKKNLQSTTMSIQGKDFRLILLKYNDS
                     QNRSYDSGINLQYIKQQLQDLVECNNSSVHHSGFTSWQHGIWGLDTYEEIKKEYKKIPM
                     EKKSILGFVFTLYEHKILMLKRMEYLKERYSIESCSEKMSLVVKKWKCLKHCVKIQYYK
                     KRKLIM"
     CDS             13675..14817
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 188.1; E-value:
                     4.5e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg307_15"
                     /transl_table=11
                     /translation="MNNEELLNHYLVRGFMEMLVFRVNNQFFNEIRKAQKAKDEIVSSK
                     VKMRLIHEAFFTIFVLLVDMLNIIILIYAWSSKSLSVGSMVALFTLIENAYTPIAIFNV
                     IYVQYKLDKASYTRFEQFLHAKDDTQLTDGMLINESIEDISIRNLSFQYEERQILNDIC
                     LSIRKGEKIAFVGESGSGKSTLVKIVVGLLKYNKGQVCLNGVSLNGICLNELYNRVTYL
                     SQDAPIFDGTIKENVVFDKAVSDEKILEALMKVQLSYLLENVNNGLYTEIGEKGTCLSG
                     GEKQRLALSRLWFDESELVILDEATSALDNLTEENVMREVILHLKEKTVIAIAHRLNSV
                     ISFDRIVVFRDGKIVDQGTFEYLISNNDYFWELYNSSVQQ"
     CDS             15387..15641
                     /locus_tag="ctg307_16"
                     /transl_table=11
                     /translation="MQSMYAKDMTTRDISAHRKSVYGVDASAEMISHMTDRILPIAKEW
                     QNRLLEKKYAVVFMDAVHFHVRQDSQTVKKDVYVAIEFA"
     CDS             15665..15919
                     /locus_tag="ctg307_17"
                     /transl_table=11
                     /translation="MWLVGNESVKYRLGVLNEIKHRNVEDIKIVSVDGLTRFGDTIDVV
                     FPPTEIQRPSGTLHYEVCELQRFQALCKGFERSLSGCNR"
     CDS             complement(16324..17145)
                     /locus_tag="ctg307_18"
                     /transl_table=11
                     /translation="MNIKSFGQHYLENEKYLLLLIESAELKKEDVVLEVGAGDGRITKR
                     IAQQVKKVVSYEIDNSTKNELQEVKNEYYNVEIYFENFLKVKKLCKIDKVVASLPYQIT
                     EPFIEKIKDIPCQSITLIVGATFAKNVTNTFLHSKLALLTNCYFSAIKICDVPEDAFLP
                     PPKTLSSIIKLIPKSKKELVDEGGLYILREIFEQRDKKIKNALQYSIIRFYNIKGILLT
                     KRKCKKILKEYLVTLRREDIALEQMTNKEIVAMYKYICSVAESVNYFVQIS"
     CDS             complement(17251..17454)
                     /NRPS_PKS="Domain: PP-binding (8-61). E-value: 3.5e-12.
                     Score: 38.6. Matches aSDomain:
                     nrpspksdomains_ctg307_19_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg307_19"
                     /sec_met_domain="PP-binding (E-value: 1.2e-12, bitscore:
                     38.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKEMNKFELNYEENLFDLGMDSIKYVNLIVKLEMYYNIEFNNEI
                     MNMTEYDSISKISEYVAKLISS"
     aSDomain        complement(17272..17430)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg307_19_PP-binding.1"
                     /evalue="3.50E-12"
                     /label="ctg307_19_PP-binding.1"
                     /locus_tag="ctg307_19"
                     /protein_end="61"
                     /protein_start="8"
                     /score="38.6"
                     /tool="antismash"
                     /translation="ELNYEENLFDLGMDSIKYVNLIVKLEMYYNIEFNNEIMNMTEYDS
                     ISKISEYV"
     CDS_motif       complement(17383..17412)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg307_19_0001"
                     /evalue="5.70E-03"
                     /label="PCP_mC"
                     /locus_tag="ctg307_19"
                     /protein_end="24"
                     /protein_start="14"
                     /score="10.1"
                     /tool="antismash"
                     /translation="NLFDLGMDSI"
ORIGIN
        1 aaaaacagag aatttcgcca tgaattacta tgattataac agaaatccaa tattttttct
       61 ctaaaattat tcgatttcaa gcaattttta aagacacggt ggaatttacc tgtgcactgg
      121 aatttaaaat ttcaagtcag cccgttcata catatttatc attcacattc tcagcatttt
      181 ctgcccttgt tcttcaagcc tctccggtgc ttccttcctc cattttatcg ccctccagcg
      241 cctctatttc gcctgtattc ttcctttgcc cttctacctg tccataccac tctgacagtt
      301 cctcaataag gcttgtacac gcctcaatat ccgcctcata acctgtgcag tgttctgtaa
      361 tcatatcctt ccggtatctt tcaatttcgc ctattgcttc ctttatgcgt tcaccggaaa
      421 ttccattttt tccaatccat ttgttctttt ctccttcctg tgtgcatttg cagcaacaat
      481 aaaacgcccg atccgcatcg ggcattttat tcttaccgca accggcagga ataacgtttc
      541 ttattcactt actgccattc ccgccgtaat ctcagtcgta tcggatctcc tgttctacta
      601 cgatacctga tttaaactgt atcatcagtt tctcctcaga gattattttt accgtagaaa
      661 tcagtctcct tacgagatca ttatcgaatt ccggtatccg gcaggtagtc gttcttaaaa
      721 agtcatcaat ttcatacatt ctttgattgc attcccttaa tgtctcctcc ctttttctgg
      781 tttctgtttg atttttctta atcgactgaa tctcctctgc aattgcatgg tatctggcat
      841 caaattcctg tgtatattct cccgcctttg cattttccat gatcagggca agcatttctt
      901 cctgcttatt tttcagaagc gtatcatagt cattttcctc ctgcagtgct tccttcgtat
      961 ttatcacact tatgacattc tgccggaatg tctctatgaa ctctctgtca tcacaggtta
     1021 tcctatggat tgcctccatt accgctcgat ttaatgcttc ttccttgatc gtctcagagt
     1081 ttgggcattt cttcacgccg tttgtcagtc tgtttgagca tctccataca attttctttt
     1141 ggccgttcct cgaccatgtg actcttctgt attcgtgtcc acattttccg cagatcacta
     1201 tgccggtcag tgcatagagc gaagagtatt tgcttttctg atttttcttc cgtgttaccg
     1261 ccgccttaca cagatttgct ctccgcattc gttcttcctg tacccggtaa tatatttctt
     1321 tggggataat ggcttcatga tcgttttcga cataatactg tggcacaatt ccattattca
     1381 ctacacgttt ctttgtcata aagtctactg tatatgtttt ctgcagaagt gcatctccca
     1441 tatatttctc attacacagc atattatcaa tgactgtggt atgccacctt tcctgtccgg
     1501 tagccgtttt gattttcttg tcttccagat atttcttaat cttgacggaa ctgtatccct
     1561 ccagatatag ccggtagatc agttttacga tttccgcttc ctccggtact atgatcaggt
     1621 caccgttttc attcttggta tatcccatga attttgcaca gtttacaatg acctttcctt
     1681 tttcaaattt tcttgcgata ccccaccgga cattctcact gatgttacgg ctttcttcct
     1741 gcgcgaggct gcttaagatg gtgataagga tttctcccgt tccctccagc gtattcacac
     1801 cctctttttc aaaaactatg gcgatgtttt ttgccttcag ttctcgaatg gtcaccaggg
     1861 aatctaccgt atttcttgca aatcggctta cggatttagt aaggatcata tctatttttc
     1921 catttagggc atcctttacc atagtcttaa aatctgctct ttttttggtg ttagttccgc
     1981 tcttaccatc atccgcataa attcctgcga atttccagtt aggattatct tgtattttgt
     2041 tggtatagta ttccacctgc gcctcatagc tgctgtcctg ttcttcttcg tctgtactga
     2101 cacggcaata tgcagctacc ttcagcatct tatctgaaag tttaatgcta gtatcgaact
     2161 gtacttttgc aggtattaca gacacctttt tagctgttgt acccatttgc ctcctttccg
     2221 ggctttttat ccgtgtaccc taccttcatt cgtccaccat tcaggaattc tacttctgcc
     2281 atattcccgt tgcataaata aatcttccga atcagctttt tgtataattc cctgtcgaat
     2341 tccactatct tttcccggcc ggcaagaata tccctgattt cttccgtttt atacaaagca
     2401 tcttttactg ttaatgtccg gtagcgttcc tctgcccttt ggtacaatgc ctgtatgaat
     2461 tctttttccg agaccgcttt tcctttcatc tctgctattt tccgatccat tcttcggtat
     2521 tcaggactga ttacatcctc cgggtctttc ttatataaaa gtccctgatt ttgaatggct
     2581 gcattaattg cgtccacgca cacctgtttt atctgatcat ctgtgatagt tctgtctctg
     2641 catttctcct gttttttgta taagtaacct ttgcacttcc agttcacatt tgtaccatat
     2701 ttatgccgct tctggatacg gatacacata gttccgcatt ccccacacca cacagcacca
     2761 ccaaacagga ttctctcatc ctttcccggt ctgtggtttg ctctgccaag ttcggctctt
     2821 acaccctctc ttctcttttg tacccggtta aagagatcct tttcaatgat ctgaggataa
     2881 tactcgttac ccagataatt tgaattctcg agtattctcc ctatggatac atgtgtccat
     2941 gacacttttc cgtttccatt gggaattcct ttttccttta atccggcagc tattttcgtt
     3001 gcagctattc cacagtcata ttctgtaaaa atctgtttta cgattttgcg tgcctcttca
     3061 cagatgatga tccttccttc ctcaacttta tatccgatgg gcatatgaca ttgcatctga
     3121 cattcctccc ctctctgtaa ggcgcaaccc attattcaga caaaatgtaa tatcatgatc
     3181 cctggatatg aagatattct gtacagtcat ccgaaaaagt ttttcatcaa acttctgctg
     3241 cagcccatcg gacccggata gtaaatggat cagctgctct gttctcacaa tttcttttgt
     3301 ccttttttgc tttcttccca aaaacagttt ttttcttcgg cattccgtta gtttccagtt
     3361 aatctgatta cttttctcca taaaaacagc agagtccata tatccattcc tcattacctg
     3421 attcaggatt cgactctgct ctttcaaatt cttgatttca ttatccagtt gtatcatttc
     3481 ttcgctgtcc tgcctgctat cggcaagact ggtcagttct ttccacagag gctctaacaa
     3541 cgctcccctg ttcgtatata gcttattcca catccgtaga aatgcctgtt gtacgacatc
     3601 ttctctaatt gcctttgtgc tgcataattc cttattttcc atatgtcttc gacacgtcca
     3661 tatgactttc tcataatttt tatctttgtg gacgatttgc cttctgaatt tttgtccaca
     3721 ttcctcacag ataattttac tggaaaataa gtatctctta ttgtaatccg ttccttccac
     3781 gttcctcgat cttgtgcgat aagctatcaa attccttact gcctctgcct cctcatgcgt
     3841 aataatcgcc ggatgcgcat cttccacaag atactttgct ttctgtccgt aatttctctt
     3901 tctgttaaac gggaattgtg actgggtata tttcttctgg aaaatcatgt ttccttcata
     3961 aaccggattt ttcagtatct ccagaataac cgtatctttc cattcttctg ctcctcgtac
     4021 tgtgggaatt tctcgcatat ttaattctct tgctatcaca taagttccta aaccatttaa
     4081 gtacgactca taaatccatc ggacgatttc tgcctccgat tctacgataa caaaatttct
     4141 gtttttatcc ttttgatatc catatggtgg tgtggataca ataaaacttc catcttgaaa
     4201 tcttttccgg actgcccatt gaacgttgct agatatgctt tcggattctc cctgtgcaac
     4261 cgatgccagc actgttagga gcatttctcc cttttccgtc agggtattga tcttctcctt
     4321 ctcgaaataa actgcaaccc cgatctcttt cagtcgccgg attgcctgga tacattccac
     4381 cgtatttctt gcaaatcttg tcaccgactt tgtaagaatc atgtcaatgt ttccatcctc
     4441 acagtcttcg atcatcatat tgaattcatc tctgtgattg gttttagttc ctgtgattcc
     4501 ccagtctgcg tacaccccgg caaattccca caagggattc tcgccgatct ttgccgtata
     4561 atactccact tgtgcagtgt aagacgttgc ctgcgacgag ctttttgtac tgacacgcgc
     4621 atatccgcaa actctctgtt tacattctgc aagtacattc tgcggtcccg ctgttgcatt
     4681 tatgacggta atttttttcg tcatattctc tctcctttcc ctgtattttc aagggatacg
     4741 ccccttgtca gcaacataca ctaccacaca atttcacata tatccagtgt ttttacagat
     4801 atacttttgc aagttccgga gaaaaggtct gaatgttcaa aaccgtgatt ctttcccatt
     4861 cctcctcatt taacagatct gcctcacgca ttctttttaa cagcacttct gccagtttat
     4921 actttatttc atttgaaccg ttccccactt gctcctccca ataacatgat cccgattacg
     4981 gcatactcat ttccgccatc gtcactgctt cgtcctcttg ctgaaaatac ttatccgcca
     5041 cgcttctgtc tactgccagc acttctcccg gttcttcatc tccacactgg atcggaaaca
     5101 gaagttcctg taattccata cataatttcc ggctcgtaca ggtattaatg aagcagccaa
     5161 aggtattcag ttctagatta tctgcgatat ctgtgaacac catgctttcc gcttctacca
     5221 tatacgttcc gatgtaattc gcaatattct ctggagtcat ggaaatgtaa tgctccttcc
     5281 ttgccccacc atccatcggg tacatatacg cataccccac tttttctgtt gccatgattt
     5341 tctcaatcat ttcccgatct tcttttttca ttttctgctt tcctccgttt tgtcctttgg
     5401 gtaaacttaa taccacaaga atacggcgga agtctccctc cgccgcatga attctgttat
     5461 taagtcttac tgccataatc cttcactttt aatactctgg ttcctattcg acactactcc
     5521 ccggaaccga aatgccgcaa agacagaaag aataaacatc aaggcatttg ttgggcagtc
     5581 aatccagact gtctgcggtt cctaccgtaa aaggcagaca gacatcacag gaatctcacc
     5641 tccaccactg cgtgctggct aatctcaagg agtatcatta taggccattt ctttcttcgc
     5701 acctgtctac cacagaccgg ctgtatcctc ggttgtctcg ctcaactcct tagatgcgat
     5761 cttttttaca tttggcacac aaatgcagga gtatcttcgc gccccgttta cggctcaaga
     5821 aatggctaat gtatctggat tgctgggtat ggctggcaaa acacggtgta attctgtgtt
     5881 gctctcgaag taagtgtaaa aactcttctc cggcatttgt caatgtgcgt atcatgagaa
     5941 gattttcgga agagaccatc cgtccgataa agcacctctc ataaggtact cacacaaaat
     6001 cggcgtttga cacccctcta ctcaaaaaat ttttttaaag tatttataga tccccggata
     6061 gacttccaaa caacattttg agaaacaccc agtttatcag caatttctct agttgtcatt
     6121 cccttaaaaa aataaagatg cagtcgctct ttttgtactt ccgtgagtga ctgcatcgct
     6181 ttttgtaaaa tctctatttc aatctgcctg attatcatat cctccagaga gattcctgtt
     6241 tccttgatta aatcctctgt cattccctcc acataaccat ttactgttat gtgccgtaaa
     6301 tctctcattt cttctgcatg agtttctttt cggaaagtat taaccaaagc ttcatagacc
     6361 tcctcggtga cgtatgtata ttcagtttcg ccgactgcat ctttgtagaa atcctttatt
     6421 ctaatcttta tacactttga cattttgtat tctccattcc taaaattctc gaagtgaaga
     6481 acacatggcg gacctctgcc tctatgtata ccccagaaga ctccgactaa aaacacaatc
     6541 cattactccg gatgtatact aaaaacgtaa tgattgtata tatggtgtct tactttggat
     6601 aaatatcaaa aacccctcca aaattacttt cggaagggta tacttttctg ttctttttaa
     6661 actattcaat cctatatatc gtgagcaaaa aatactattt gtccaccaaa aagactttct
     6721 tctacaaaat ttcataaaac cctccacctc actaatgttt ttcacattat cctgcaaagc
     6781 ggaggacaat atttcctttt ttactaaaca atgctattta ttaactgaat ttatattact
     6841 tcacacaatt cggataaaat tttaagtata tcctgaatct tactcgtttg ttttggttcc
     6901 agcttttcta atacacaaat aatcttttct ttgccgccac ttcccgcatc ctcaccaagc
     6961 ataatataat cacagcttac agataaagct ttcgatattc tacataatgt atcagcagaa
     7021 aatcccttct tgcccatttc tatctcataa agaaatttag ccgaaatatc cactttttca
     7081 gccaaacctt ctcttgtata attttgtatt tcccggagtt ctcttatcct tgccccaact
     7141 tctatattcg acataatcta cctccagatg ctataattct acatcttatt accagtagtg
     7201 ttaaaccgtc cgttgttcat acgctctata cctccagttc taagtttaca tcataaacaa
     7261 ataagccata acttatttac ttaattaata aaaaaattgt ccgaaaatcc aagaaattcc
     7321 tctctgaaag ctttatcata tgcttatcta cccatttttg tatgtcagta aaaaaaaata
     7381 tatattcagt tcaaaatgaa gttttttcag ttttatggga tattcttgga atagatgaag
     7441 ggagatcttc gtatggacag gataaaaata tatattaaag acaaatatgg attaagtaat
     7501 tatcaaatgg ctcaacttac ctttgtaatc aaaagtactt catcagaatt aagcaaaata
     7561 ctactgatgg gtattgcgtt tcaaaaccat ctaaaactat atatcttctt attaataata
     7621 atgtgttttt taagaacatt ttccggtggt cttcattttt acacatacaa aaagtgccta
     7681 ctggcatcca ccacatatat gggaattatc atcttctttt tttcaaaaat attgcttcct
     7741 ttatatgtac aattgctttt attaactgtg tgtattatgt cctgctattc aataggtccg
     7801 gttctctcta aataccgaac tcattttcct agaaagcaat tatatttttg tcgtaatatc
     7861 acctgcctta acatttttat gtatgcatta atcctatata taatccctaa aaatccctat
     7921 cttacagcag gggtttggat gattatattg cattcgctcc aattgtttgt tgcgaaaata
     7981 caaaagaaag gagagacaac acaatgatag cgcatatctt agtaactgtt gctgcttttt
     8041 catggatcgt ggatacttca ctacccagta ttgttttatt tggagaatat ccctacccct
     8101 ctgaaggaaa tgaataatta gcagaaagac ggataagttt tttattactt atccgtcttc
     8161 gctatttcca gagtgaattc tacccagttt tcactatcat ctaatttatt tctgcataca
     8221 atatttgcat cgtatttctc acataactct ttaacattat atagtccaag tccacgatgc
     8281 tttcccttac tacttttatc tatctggaac caagattgga tttcgacata actcacatac
     8341 aaataaggat tggaaacatt aaatatatat gctacctctt tttccataaa ctgaaatttt
     8401 agctgtttta tttctattga actctcttgt gcctctaccg cattatcaat taatattccc
     8461 aatatatcaa tcaaatgata gattggcatt acacattgag aaaaagtacc ttttatatca
     8521 cagcgtattt tcactcccat tgtttccgcc acgcgaaatt tttcatatag aaatccaata
     8581 acaacactgt ctttcaagta tagcaactta ttgtatttat tttcgtcaca aatcttagaa
     8641 taataccgct cttgttctgc aaccagctcc tcatatgagc ggcttgtata ttttatagac
     8701 agtaaagctg ctaaatgatt cttaaatccg tgttctcgta atcttacaga agtcaataaa
     8761 tcttcatatt ttccctgcat cgtccgattt agcgataatt catttttaga attctcggct
     8821 tcttcattag caatatgcca tttacttaac ccccagagaa gaacaatcaa cataggtacc
     8881 gaaatagtga agaatgctaa atgtatttgt ttaccaattt tatcttctaa catgatcatc
     8941 aggataacag ccataactgt tcccaatatt atagcaacat aagtatctct cttcataaaa
     9001 atctcatgta gtttatgtat cctaactaat ggtagaatcc atattgcagc agctaaaacc
     9061 aacccatttg tacttaacat ttgcaattcc aaattatttg aaaagagata tgaacaagga
     9121 aatatcgcta tgtattgcaa aactactata actattagta acagtaaaac gcttactatt
     9181 gatccaatga ctgagtcatt atatttacga acacaatata tccctataag tatgtatatt
     9241 attattgtga acaaattact aagtccataa tatctcacaa gttctacaat agttaaagac
     9301 atcaaacaca gcccgactga gtcaatattc aagcatactt ttctattgta tattctttga
     9361 agtataacaa ttattgcaat atattcgagc atcagtcccg catgatataa catttattac
     9421 aaatctcctt ctcttcctcc ttctttgtgg atatgcacga tctatacatc tatacctttt
     9481 agatttttct taaatctaat acctattcca actcgaccat agccattttt caatttaatc
     9541 acttgattag gaatatctaa attctcaata tatttttgat taattatggt gtttcgactg
     9601 cattgaataa aatccgagca atccaaatcg tccaaaaatt tctttaaagt tatatatgga
     9661 atctcaagag ggtcactctg tttagtgtga atatgcatta tatgattaat actttctgcg
     9721 taaacaatgt cttcacgctc aacagccaaa ataattccgt cttttctaaa atatagcgtt
     9781 ttggatatat tccgggattc ttcaaaacgc aggcactgtt ccaccaactg cttaagtctt
     9841 tctacatcaa atggcttttc aataaaacta tagcaatgca gattctcata agtgtataat
     9901 tttgcgtctt ctaaagatgt aacaaatatg atcggcacaa actcatagtg atttattttt
     9961 ctgatatttt ccacaaactt tagtccagat gaatctcctg gcctatttct atctagaata
    10021 atatccacaa taaacaagtc aattacccta tccatggcac actgatatgc atcttttaat
    10081 tcatgaaacg gatatactgc atttttggca tcaacatctt gaacgatctg agtaagattc
    10141 ataagagtag ttaggttatc ttccagtatc aatacctttt tcataatgtg tcctcatcat
    10201 atctgtctga taatatctat tatttctgct ccgttttctt cagcagcttc cagaagagac
    10261 gatatttcat taatcatact atttttatcc ttcaatacta ctgccggaga tatatgaaat
    10321 agattgtata atttccaaat aatttcgcta tctggcaaac atctgtcctt ctctaattcg
    10381 cgaaattttt tgatatcaac acctaatttt tcagccattg gctcttgccg actacaagtc
    10441 gtgtgtctaa taacaagaaa tatattggaa gacttttcac aatccagtac taatggcaca
    10501 tattttaccc tcttcacgat atccttccat tgctctgtat tggatctgca atcattcaaa
    10561 actatcagta aataaataat gcctaaataa cagcacaatt caacatatgc acattgttgg
    10621 aaatacgcaa catactttcc agcacatcta tatcctgtaa atatataaaa aatatctatg
    10681 tttgctttgg aaagatattt taactcttca taactcagac ggtgtagccc cttttccact
    10741 ttactgtagt tactttgcgt aatatgaacc aaacgggcca tttgttgctg agataacccc
    10801 aagcattttc gctcttctat cagccttttt aacatttcat tatacgttgc actcataggt
    10861 aatcttcctt tgaactataa ttctattttt acccatttta agttatatta tttacctatt
    10921 ttgcaccgtt ctacgactat catcattgat gtgtcatttt atatagcata attagtataa
    10981 tcgtgataaa aacagccata ttaaagacca aaactgatcc ttaatatggc tgctaattaa
    11041 ccactaagta taaaattttt taatattaaa gtaacagtga cttttacact ctcttaaatg
    11101 aggttttacc tgctatcact aaaaacatga tgggtacttt tataaaaaac atacaaatat
    11161 gtgtatgttt aagttttaat atttgaaatg tattccgtat atatttcttt ttctaattcc
    11221 ccctaatttt gtcaagatca tgttcaaatt tacataataa gctttctttt tttgtaatat
    11281 tgtattttaa cacagtgttt taagcatttc cactttttta ctaccaaact catcttttct
    11341 gagcaacttt caattgaata tctttctttc aagtactcca ttctttttag cattaatatt
    11401 ttatgttcat acaacgtaaa tacaaaccct aatatcgact tcttttccat tggtattttc
    11461 ttatactctt tttttatttc ttcatatgta tctaagcccc atatgccatg ctgccaactt
    11521 gtgaagcctg aatgatgtac cgatgaatta ttacattcaa ccagatcctg aagctgttgc
    11581 tttatatatt gcaaattaat tccggaatca taacttctat tttgtgaatc gttatatttc
    11641 agaagtatta agcgaaaatc tttaccttga atactcatag tagtagattg taaatttttc
    11701 tttttccatt caaatttata gtatattcta atgctacaag caaatccctc aaatttcaat
    11761 ttataatttc caatttttca gaaatcccaa aattcattag ataaaaaata tgatctttct
    11821 tcatatccaa aaataaattg agaatgaatc acatctgaac gattaaaaaa tctgagtatt
    11881 tggtattttg actctgctag ataaaaaact atatagttac cattatcaat caatatttca
    11941 tatcttcgat tattgtttcg tgcctcattc tataattgtg ttggcacaac tctgttgcgc
    12001 tcaaatacaa tttatcctga tgtcacaaaa tctgagtttg gataataatc tacctttcca
    12061 aaccgttgtg gtatagtaac tgtatgagat tattatatat ccaatctgca cacacaatag
    12121 ctgaagacgc tatatggcaa atagcttgta attgagtaat tggaaaatac aatgttaatt
    12181 tttttctcta tttttcttca tatagttact ctcatataat atttatgatc taggcattta
    12241 tttaagtcag tatgcaaaaa aacaaacttt ttagttcact aaaaagaact cctctaaatg
    12301 ggttagaaac attaacccaa ggaaatcgtt gtgaaggcta ctctgcctat gcaaccatgc
    12361 ttttcaggca aagtgtctct ctttactgcc gaatacacct gccccactga gggcttatgt
    12421 cagtgttaat gaataacgtt tctgctgaca acactgaatg actctacatc tccggaatga
    12481 tagttcttaa aatccggaca aatggctcaa ataattattg ctatatttaa acaagcaaat
    12541 cttacttata ttatttacaa tgccttatag tacttatcaa ctctataaac cctaaagact
    12601 agaaaatgaa aaaatccctg ttcattgcag gtttcgttca aagcaaaaat ttctccgcgc
    12661 ataaatcaag agttataaat atgtttataa cttctcgtat tatgtttata ctatattttt
    12721 aatcataaac atatatttag gttataaggt agtttttacc ttattatctg gtgggcgaga
    12781 taaagctaaa ctgaggatat ataaatatta gtacttttga caatccccag aaaccatctt
    12841 ctatttcttt ctgtttatac caatagtgca gaaaaaatta ttatattaaa ttgaatttaa
    12901 atatacaaat tatataaact cagtattgaa aatgtagagc catagtagta taatctaacg
    12961 aatatgaaat atttatttag atgaaagagg gtgaaatcaa attgaaatac attcgagata
    13021 attactcagt acagttgact taaactgtta gcagattatg ctgagattaa tattaacttg
    13081 ctagcagtca caattgtact gttccgaaaa ttaaaaataa ggagtacaat tatgcgctat
    13141 ataaaaatag tattgaaaaa aacatattaa tagtattgac ttacatagga ttgggcattt
    13201 ttaatgcatt tatgtctaat tataaggctg attattttca acgatcattg acgggttatc
    13261 tgccggaaaa cttgcaactt tacaaacatt atgatttatg gttctatttt gattagtatt
    13321 cattgtatgt catattttga taattaccca gaccaaaagt tggcacaagg tatttactta
    13381 gactttaaat tattagccac taaaaaagta caatagacta tatggcatat caaaaaatag
    13441 gtaccggaaa acttgttcaa aaagaattga gaatggcgca tcggctggaa ggaaatgtta
    13501 tatataactt tttggctacg tgtaatacga gttgcttcca accatagtat tgcatctatt
    13561 tcattttgaa gaaataaata aagctattac ttatgcattg cttatcggct atgttattat
    13621 tttataataa ccaatctctt attaaaattt ttgtatcaaa taaaggaaag aatattgaat
    13681 aatgaagaac tattaaatca ctatttggtc cgtggcttta tggaaatgtt ggtatttcgt
    13741 gtaaataatc aattctttaa tgaaattaga aaagctcaaa aagccaaaga tgaaatagtt
    13801 tcttcaaaag taaaaatgcg tttgattcat gaagcatttt ttacaatatt tgtcttactc
    13861 gtagacatgt tgaacataat tatccttatt tacgcttgga gcagtaaaag tctttctgta
    13921 ggttccatgg tggctttatt tacacttata gagaatgctt atacaccaat agcgattttt
    13981 aatgtaattt atgttcaata caaattagac aaggcgtctt atactagatt tgaacaattc
    14041 ttacatgcta aagatgatac gcaattgaca gacggtatgc tgattaatga aagtattgag
    14101 gatatttcta taagaaatct ctcttttcaa tatgaagagc gtcaaatttt aaatgacata
    14161 tgcttatcta tcagaaaagg cgaaaaaatt gcttttgttg gggaaagtgg gtctggaaaa
    14221 tctacacttg taaaaattgt ggttggctta ctaaaatata acaaaggaca agtttgcctt
    14281 aacggagttt cattgaatgg aatttgtctt aatgaattgt ataatagagt tacttattta
    14341 tcacaagatg cccctatttt cgatggaact ataaaagaaa atgtagtttt tgataaagct
    14401 gtgtctgacg agaaaatctt agaagcattg atgaaagtac aattatcata tttgcttgag
    14461 aatgtgaata atgggttata tacagagatt ggtgaaaaag gaacttgttt atctggtggc
    14521 gaaaagcaac gccttgcttt atcacgccta tggttcgatg aatccgaact tgttatttta
    14581 gacgaagcca cgtcggcatt ggacaattta actgaagaaa atgttatgcg agaggttatt
    14641 ctgcatttaa aagagaaaac tgtaattgca attgctcatc gtttaaattc agttattagt
    14701 tttgatcgaa tagtagtatt tcgagacggg aaaattgttg accaaggcac ctttgagtat
    14761 cttatctcta ataatgacta tttttgggag ttatacaatt caagcgtaca acaatagaat
    14821 atttttctca atggatgttt atagcgactg taaagaattt gtgtgagcta gatatgtagt
    14881 atatatcctc ttggattgat gttaaaataa atattaatcc aggaggatat ttttaggata
    14941 atcaaggttt ttgaggtttt gtcaatctaa ttgaggattg aagtataccc tggcattaaa
    15001 tactctcact tgacaaaccc taaagctaga ccctaaaaaa ctttgaatac ccagaaaact
    15061 ttcaccagaa cgcgaggcgt tcatcaacag cttattggag cactaccagc caacagatgc
    15121 caatgatgtg caggaaatgc tcaagaactt actgggcgat acccttcagg gcatactgaa
    15181 ggctgaaacg gaccagaaaa ctgggctatt ccaagtacga ctatcagaac aaggttacag
    15241 atgacagcag aaacggctac agctagaaaa ccgatacctc atcacttggg gaaattgaac
    15301 tcgttattcc cagagatcac aagagcgagt ctgagccgta gattgtcagg aagaacctga
    15361 ctgacatctc aaacattgag gatcaggtgc agtccatgta tgctaaagat atgactaccc
    15421 gcgatatctc tgcccatcgg aaatctgttt acggtgtaga cgcttctgca gaaatgatat
    15481 cccacatgac ggatagaatt ctccctatcg ctaaggaatg gcagaatcgt ctccttgaga
    15541 agaagtatgc agtagtcttt atggatgctg tacattttca tgtgcggcaa gacagtcaga
    15601 ccgttaaaaa ggatgtatat gttgccattg aatttgctta aatggatgca aagaaaccct
    15661 gtgcatgtgg cttgtcggta atgaaagtgt caagtaccgg cttggtgttt tgaatgagat
    15721 taagcaccgt aacgtggagg atatcaagat tgtatccgta gacgggctga ccagatttgg
    15781 tgatacaatt gatgtagtgt tccctccgac agagattcag cgtccatcag gtacgttaca
    15841 ctacgaagtt tgtgaactcc aaagatttca agctctttgt aaaggatttg aaagaagtct
    15901 atcaggctgc aacagatgaa ctggcgctag aaacctcaac gcacttgaag agaaatggga
    15961 caagaagtat cattcttccg tagcctcatg cgtaataacc ggtcacagct gtccacatat
    16021 tttaagagta tccgcctgag atgcgaaaat catattcacc acgaatgcaa taaagaaaga
    16081 tttttaacca ttagctccgc aaagtgacaa agtcaaaaac cacctttcac cacggacgac
    16141 gcactcttca atatcctgta tttggccatg tatgatatca cagaaaaatg gtctggaacc
    16201 agctgaaacg gaggacagat cttagaccag ttgtgcattt attttgaggg tagaattttg
    16261 tgtaaaaaac aacatgtcgg gagttcaaat ccccccgaca ccataaactc aatatttttt
    16321 aatctaagag atttgcacaa aataatttac actctctgca actgagcaaa tatacttata
    16381 catagcaaca atttccttgt ttgtcatctg ttccaatgca atatcctccc tacgaagtgt
    16441 tacaagatat tcttttaaaa ttttcttaca ttttcgcttc gttaacaaga ttccctttat
    16501 attataaaac ctgattattg aatattgtaa tgcatttttt atttttttat ctctctgttc
    16561 aaatatttct cgcaaaatat aaagcccgcc ttcatcaacc aattcttttt ttgatttagg
    16621 aataagttta ataatagatg aaagagtttt aggtgggggc aaaaaagcgt cttctggcac
    16681 atcgcatatc tttattgcac taaaatagca atttgttaat aaggccaatt tactatgtaa
    16741 aaaagtattc gtaacatttt tagcaaaagt tgcacccaca attagagtaa tactttgaca
    16801 aggaatatct ttaatttttt caataaatgg ttctgttatt tgataaggca aactggctac
    16861 tactttatca attttacaaa gtttttttac tttcaagaaa ttttcgaaat agatttcaac
    16921 attatagtat tcattcttca cttcttgaag ttcgtttttt gtactattat caatctcgta
    16981 agaaactact tttttgactt gttgtgcgat ccttttagta atacgtccat caccggctcc
    17041 aacttctaaa actacatcct cttttttcaa ttccgcactt tcaattagta ataataaata
    17101 tttttcattt tccaaataat gttgaccaaa cgattttata ttcataatat aaaaatagcc
    17161 actttctcta ccgttaattc atctataatt gctatatctt ttccaccagt cagtaacact
    17221 actatttttt atgaaataaa atatattaaa ttaactactg ataagctttg caacatattc
    17281 tgaaatttta cttattgaat cgtattcagt catgttcata atttcattat taaattctat
    17341 gttataatac atttccagtt taactattag atttacatat tttattgaat ccattcctaa
    17401 atcaaataaa ttttcttcat aattcaattc aaatttattc atttctttat ccat
//
