LOCUS       c00030_gnlPro..        16950 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DGCEBJHE_30.
ACCESSION   c00030_gnlPro..
VERSION     c00030_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 16:52:55
            Original ID  :: gnl|Prokka|DGCEBJHE_30
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16950
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16950
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3610:6950]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3611..6950
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..16950
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16950
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             113..214
                     /locus_tag="ctg30_1"
                     /transl_table=11
                     /translation="VPFSFSYIYQAHGIGIMPLHAVYTREENLRWNI"
     CDS             202..1212
                     /locus_tag="ctg30_2"
                     /transl_table=11
                     /translation="MEHLIIPKDYHSELNLHDTQIAIKTVKDFFQNLLALRLNLSRVSA
                     PLFVDPLSGLNDNLNGIERPVTFDIKEQNGKEAEVVQSLAKWKRYALKKYGFDYGEGLY
                     TDMNAIRRDEDTDNIHSIFVDQWDWEKIIHKEDRNIETLKETVTTVYNCLRKTEKYMAI
                     QYDYIEEILPHDIFFITTQELEEMFPDNTPKEREYYITKTKGAVCIMKIGDTLENGEPH
                     DGRAPDYDDWSLNADIVVYYPVLDIALEISSMGIRVDKKALLSQLKKAGCEERAKLPFQ
                     KAIINEELPYTIGGGIGQSRICMFFLRKAHIGEVQSSLWPEAIAKECEKNGIQLL"
     CDS             complement(1448..2260)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_3"
                     /sec_met_domain="CN_hydrolase (E-value: 9.3e-48, bitscore:
                     153.1, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKAAAEGANIILLPELFEREYFCQQRRYDFYSYARTVEESEAV
                     AMGVRLAKELGVVLPISFYERDVNNLYNSIACIDGDGTILGVYRKTHIPDDHYYQEKFY
                     FTPGDTGFKVFDTKYGCIGIGICWDQWFPETARAMALLGAELLFYPTAIGSEPILECDS
                     MPHWRRCMQGHAAANLMPVIAANRIGREVVQPCAENGGQESALEFYGSSFLTDETGEVI
                     LSASRDKEEILSQTYELDELRAKRLEWGLFRDRRPEYYGIIAGEKNGR"
     CDS             complement(2416..3639)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_4"
                     /sec_met_domain="PAD_porph (E-value: 1.1e-117, bitscore:
                     383.2, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISKADCPEMIKDTTPVQDGFFMPGEFEQHQGCIMIWPERPGSW
                     RNGAKEAETAFSAVIRAIAASETVYVAAGKKGIDHAKAFAESLKKEENLHPVVVFEMET
                     DDSWARDVAPTFLVNRTDGKISDLTAAGNGTAQTGDDVKNSQVRGVNWSFNAWGGEVDG
                     LYASYEKDNAFAWNFCRKFEFDCYDAEPFVLEGGSIHSDGEGTLLVTESCLLSAGRNPS
                     LTKEQIEEQLKCYLGVEKVLWLPRGIYQDETNEHVDNVCAFLRPGEVVLAWTNNQNDPQ
                     YAMSKASFEYLSSVRDAKARKLIIHKLPIPDIPVCITKEELEGYEFEEGEDVREVGERL
                     AASYVNFYFSNNAVVMPVFGGENEESDLRAQQIMAKLCPDRKIIPVYARDILTGGGNIH
                     CITQQIPL"
     CDS             complement(3611..4711)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_5"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 2.3e-13,
                     bitscore: 40.7, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VVDEKKLKQNLKILQNLEQETGCHVLLAQKAFSMFSLYPLIGQYI
                     SGTTASGIFEARLGKEEMGKENHVFAPAYKEKDMEELVQICDHVIFNSFAQYEKYQHYF
                     LQQECTASAGIRVNPECSTQEGHEIYDPCGPGSRLGVVKSEFPDQLPEGIEGLHFHTLC
                     EQNADDLITTWHAFEEKFGSYLKQVKWLNLGGGHHITRADYQLDELKKLICEIRRKYNV
                     RVYLEPGEAIALNAGYLVTEVMDIVHNGMDILILDASAACHMPDVLEMPYRPPLKDGYL
                     PGEKPHTCRLSSMTCLAGDVIGDYSFAQKKQVGDRLVFEDMAIYSMVKNNTFNGMPLPG
                     IAVLREDGDVEMIKEFGYEDFKGRLS"
     CDS             complement(4832..5914)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_6"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 6.9e-45, bitscore:
                     144.5, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 4.4e-20,
                     bitscore: 62.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDADNTEELIALIKKYQPDAVLNVALPYQDLTIMDACLACKVDYI
                     DTANYEPEDTDDKEWRAIYEKRCKEEGFTAYFDYSWQWAYREKFKEAGITALLGSGFDP
                     GVTSVFTAYALKHYFDEIETIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWENGH
                     WVETKPMEIKREYNFPQVGEKDMYLLHHEEIESLAKNVPGVKRIRFFMTFGQSYLTHMK
                     CLENVGMLSTSPIEYEGREIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGKKDGKEK
                     TIYIYNVCDHQECYKEVGSQAISYTTGVPAMIGAALVVDKVWDKDGVFNIEEFDPDPFM
                     DMLNQYGLPWVVDENPQTVA"
     CDS             complement(6189..6950)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_7"
                     /sec_met_domain="Spermine_synth (E-value: 3.7e-52,
                     bitscore: 166.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VFDSDEFGRFLSSDGSIVFSEKDEFVYDEMIVHVPMAVHPHVKKV
                     LVIGGGDGGVARELGYYDEIEQIDVVEPDRVFVEVCKEFFPDNACGLSDERVTVYYEDG
                     LKFLRMKHDEYDLIINDAIDPLGHTAGLFTKEFYGNCFRALKDDGIMVYQHGSPFYDED
                     EESCRGMHRKASHSFPISRVYQAHIPTCSSGYWLFGFASKKYHPLDDLDAKRWKERKIK
                     TWYYTTNLHKGAFMLPRYVEDMLEEEEGRKK"
     CDS             complement(7120..8574)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_8"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.1e-12, bitscore:
                     37.9, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.6e-130,
                     bitscore: 425.6, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKEQQMRAPVYEALEKLKKRRVVPFDVPGHKRGRGNPELVELLG
                     EKCVSLDVNSMKPLDNLCHPVSVIKEAEELAAEAFRAEHAFFMVGGTTSSVQGMVLSCC
                     KAGDKIILPRNVHKSVINALVLCGAIPVYVNPEVDVRLGISLGMQVSEVERAILENPDA
                     VAVLVNNPTYYGICSDLRSIVRVAHEHHMLVLVDEAHGTHLYFGENLPVCAMDAGADMA
                     SVSMHKSGGSLTQSSLLLTGKGVNWEYVSQIINLTQTTSASYLLMSSLDISRRNLALRG
                     KESFAKVAQMAEYARDEINSIGGFYAYGKDMVNGGSVYDFDVTKLSVYTRDIGLAGIEV
                     YDLLRDEYDIQIELGDIANILAYISIGDRIQDIERLVGALADIKRLYSKDPAKMLNTEY
                     INPKVLVSPQVAFYSQKESMPVRQTAGRICGEFVMCYPPGIPILAPGEMITPEIIEYIV
                     YAKEKGCSMQGTEDPEVENLNVLAKK"
     CDS             8632..8982
                     /locus_tag="ctg30_9"
                     /transl_table=11
                     /translation="MFFPDITVRLKNAKKEQASITCSSIVVIIIVILYVIYLHSAKTIF
                     SRVRVGIFASKYLRILLLLTVSQVILDSGYHPRNQLIKFELLTQSITRLTPQSAVAPPV
                     RMGLTNLLVGKQ"
     CDS             9063..9227
                     /locus_tag="ctg30_10"
                     /transl_table=11
                     /translation="MANAITYSVKFWYFLFYFVLGHFYFLFRFAAILPRPLPDHLYLPS
                     VPLIIVRCL"
     CDS             complement(9159..9986)
                     /locus_tag="ctg30_11"
                     /transl_table=11
                     /translation="MLIGNHLSASKGYAAMGKAALALDANTFAFFTRNPRGGKAKEIDE
                     KDVEKFLNFAKEHEFGKIVAHAPYTMNLCAAKEDVRSFSKEMLLDDLKRMEYTPYNYYN
                     FHPGSHVGQGAEKGIALIAEALNEALKPEQTTTVLLETMAGKGTEVGRTFEELREILDR
                     VELNDKMGVCLDTCHVWDGGYDIVNDLDDVLNEFDRVIGLDRLKAVHFNDSMNDCGSHK
                     DRHAKIGEGKIGAEAMRRVALHPLLEGRPFILETPNDDEGYRREIQMVREWTR"
     CDS             complement(10070..12034)
                     /locus_tag="ctg30_12"
                     /transl_table=11
                     /translation="MGQTDLRYLKSLSNQYPTIATAATEIINLQAILSLPKATEHFITD
                     VHGEYDQFLHVLKNGSGAIKRKIEDEFGNAISAAEKKAIATLIYYPEQKLEQVLKTEDN
                     LEDWYKVTLYRLIRICKNASSKYTRSKVRKALPKDFAYVIEELLTGRQEISDQEAYYNE
                     IIRSVIRTGRAAELVIAFCNLIRRLVVDHLHVVGDIFDRGPYPNLIMDTLMEHHSVDIQ
                     WGNHDVYWMGAASGSAACICNVIRISAKYGNLDLLEDGYGINLVPLARFAMKWYDKDSC
                     DCFKLDYREDEYDVHDAFLDEKMHKAITIMQFKLEGQLIKENPEFEMEKRLLLDKINIE
                     KGTVCVEETEYPLKDVSFPTIDWEDPYRLSEDEADVMERLVTAFVNCEKLQRHVRFLYT
                     QGSLYKVYNGNLLYHGCVPLNEDGTFTRVNVFGKEYAGKELYDVLEGYARKGYYAIDPK
                     EKKKGQDILWFIWENQNSPVFGKAKMTTFERYFIADKITHQEPKNPYYRLLEKEEVVNR
                     ILEEFGLEGAEAHIINGHIPVEAKKGESPVKCNGKLLIIDGGFSKAYQPKTGIAGYTLI
                     YNSYGLVLAAHEPFESVEKAVQDGSDIVSHTVLVQQVVRRKTVADTDIGKSLKESIHDL
                     EELLAAYRAGTIVEKNRAE"
     CDS             complement(12131..12898)
                     /locus_tag="ctg30_13"
                     /transl_table=11
                     /translation="MIRAIMSGCNGKMGQVITGICKEDAEIEIVAGIDLYDGIKNDYPV
                     FPNISVCDVAADVIIDFSNAKAVDDLLVYSVDKQIPVVLCTTGLSEEQLKKVDGASKKV
                     AVLKSANMSLGINMLMELLKQAATILAPAGFDMEIVEKHYNQKLDAPSGTALALADSMN
                     EALGNAYTYTYDRSKERKKREKTEIGISAVRGGSIVGEHEVIFAGLDEVIEFKHTAYSR
                     SVFAKGAVQAAKFLSGKPAGFYDMGDVIKATIA"
     CDS             complement(13002..13952)
                     /locus_tag="ctg30_14"
                     /transl_table=11
                     /translation="VCTKQCILTYHNTGTRRIINMSIFKGAGVAIVTPMKNNEEVNYDR
                     LEQMIEYQINQGTDCIIIAGTTGESSTLTTEEHAEVIKAAVKFAKHRIPVVAGTGSNCT
                     REAIHLSEEAEKAGVDGLLCVTPYYNKATQGGLIRYYTEIANSVKLPIIMYNVPSRTGC
                     NILPETAAKLYHDVENIVAIKEATGNVAQAAKTMYLTDGKLDLYSGEDGIVVPLMSIGA
                     IGVISVWSNVAPKDVHDMCMAFFDGDTKKAMEIQLKAQPLIEALFSEVNPIPVKKALNL
                     MGMEAGPLRSPLTEMTDANAAKLAEAMKNYGIKLA"
     CDS             complement(14287..14844)
                     /locus_tag="ctg30_15"
                     /transl_table=11
                     /translation="VYGEGFYMVDVAVNRLSNYMDYIPLMISERLIDVNEDMVGQNIYV
                     TGQFRSFNRHEEKKNRLVLSVFVRELEFLDEIDDEVKSNQIFLDGYVCKEPIYRKTPLG
                     REIADLLIAVNRSYGKSDYIPCICWGRNARFASGFDVGGHVQIWGRIQSREYVKKLSET
                     QTEKRVAYEVSVSKIDFLEELD"
ORIGIN
        1 aatatgtatc acaaaccgtt ttcgataaaa tttatattgt atacatgtat ttttcaagaa
       61 atcgtatgat cttttcttga aaatgagacc tgctgtgcta taataaatta gtgtgccatt
      121 ttctttttca tacatatatc aggcacacgg gattggtatc atgccgctgc atgcggttta
      181 taccagagag gagaacctta gatggaacat ttaatcattc caaaagatta tcattcagaa
      241 ttaaatctgc acgatacaca gattgcaatc aaaacagtaa aagatttttt ccagaacctg
      301 cttgcacttc gtctgaatct gtcccgcgtt tcggctccac tttttgttga tccgttatcc
      361 ggtctcaatg acaacttaaa cggtattgaa cgtccggtta ctttcgatat caaagagcag
      421 aacgggaaag aggcagaggt tgtacagtct ctcgcaaaat ggaaacgcta cgcattaaag
      481 aaatacggtt tcgactacgg tgaaggcctg tataccgata tgaatgcgat ccgcagagat
      541 gaagacacgg ataacatcca ctctattttc gtagaccagt gggactggga aaaaatcatc
      601 cataaagagg atcgtaatat cgagacatta aaagaaacag ttaccactgt ttataactgc
      661 ctgcgcaaga cagaaaaata tatggcgatc cagtacgatt atatagaaga gattcttcca
      721 catgatatct tctttatcac gactcaggaa ttggaagaaa tgttccctga caacacacca
      781 aaggaacgtg aatattatat tacaaaaacc aaaggtgccg tatgtatcat gaagatcggc
      841 gatactttgg aaaacggaga gcctcacgac ggacgtgctc cggattacga tgactggtcc
      901 ttaaacgcag atatcgttgt ttactatccg gtacttgaca tcgcacttga gatttcttcc
      961 atgggtatcc gggttgacaa gaaagcgctt ctctcccagc tcaaaaaagc aggctgtgag
     1021 gagcgtgcaa aacttccttt ccagaaagcg atcatcaacg aagagcttcc ttatacaatc
     1081 ggtggtggaa tcggacagtc ccgtatctgt atgttcttcc ttcgcaaggc acatattgga
     1141 gaagtacagt cttccctgtg gccggaagct atcgcaaaag aatgtgaaaa gaacggtatt
     1201 cagcttttgt aacaggaacg ggcatatgct ccgcagatat cctgtcatca acactgatgc
     1261 ctgataaaaa acaggtatgt ttcaaatgtc agcaatgagc tttccctgct ccctgctgac
     1321 aaaaacatac ctgttttttt catctttctg ttttttcagt cctgtgcggt ttccactatc
     1381 ttccggtctt ttcagtcccg tgtgatttcc actatcttcc ggtcttttca atcccgtctg
     1441 gttctcacta tctcccgttt ttttctcctg ctatgattcc gtaatattcc ggtcttctgt
     1501 cccggaaaag tccccattcc agtcgttttg cccgaagttc atccagttca taggtctggc
     1561 tcaggatttc ttctttatct ctggaagcac ttaagatcac ctctcctgtt tcatccgtca
     1621 gaaatgagga accataaaat tccagtgccg actcctgtcc gccattttcc gcacatggct
     1681 gcactacttc cctgccgatc cggtttgcgg caatgacagg catcagattc gcagccgcat
     1741 gtccctgcat gcagcgtctc cagtgcggca tactgtcaca ttctaaaatc ggttccgagc
     1801 cgatcgctgt cgggtaaaac aataattctg caccgagcag cgccatcgcg cgcgctgtct
     1861 ccgggaacca ctgatcccag cagattccaa taccgatgca accgtatttt gtatcaaaca
     1921 ctttaaatcc ggtatctccc ggtgtaaaat aaaatttttc ctgataataa tgatcatccg
     1981 ggatgtgggt tttccgatac acaccgagga tcgttccatc tccatcaatg catgcgatcg
     2041 aattatagag gttattgaca tcacgctcat aaaagctgat tggaagcacc acgcccaatt
     2101 cttttgcaag acgtactccc attgccacag cttcactctc ctccacagtt cttgcatagc
     2161 tgtaaaaatc atatctgcgc tgctggcaga aatattcccg ctcaaaaagt tccggcagta
     2221 aaatgatatt tgcgccttcc gcggcagctt tgcggatcat ttgttctgcc ttttgtaagt
     2281 ttttcttgtg ctccaggtcg catttcatct gaattgcggc tgcttttatc tgtctcatgc
     2341 gtgtatcctt tctgttcttt ttatttttgc acagtgaatt aattctccta tatggaaggt
     2401 tgtacaataa attccctata agggaatttg ctgtgtaata cagtggatgt ttccaccgcc
     2461 tgtcaatatg tctcttgcgt acaccggtat gatttttctg tccgggcaga gttttgccat
     2521 aatctgctgt gcacgcaggt cgctttcttc gttttctccg ccaaatacag gcatgactac
     2581 cgcattgttg gaaaaataaa agtttacata ggaggcggcg agccgttctc cgacttccct
     2641 gacatcttca ccttcctcaa attcatatcc ttcgagttct tctttggtga tacagaccgg
     2701 aatatccgga attggaagtt tgtggatgat cagctttctg gcctttgcgt cccgcaccga
     2761 acttagatac tcaaaactcg ctttcgacat cgcatactgc ggatcattct ggttattggt
     2821 ccatgcaagc acaacttcac ctggtcttag aaatgcacag acattgtcca catgctcgtt
     2881 ggtctcatcc tgatagatcc cgcgtggcag ccataaaact ttctccacgc caaggtaaca
     2941 ctttaactgt tcttcaatct gctcctttgt aagcgatggg tttctccccg cactgagcag
     3001 acaggactcc gtgacaagca atgttccctc tccgtcgctg tggatagaac cgccctctaa
     3061 cacaaacggt tcggcatcat aacagtcaaa ctcgaatttt ctgcagaaat tccatgcaaa
     3121 cgcattgtct ttttcataag aagcatatag tccatccact tcaccgcccc aggcattaaa
     3181 agaccagttt acaccgcgca cctgtgagtt ttttacatca tcacctgtct gcgccgtacc
     3241 atttcctgct gctgtcaggt ctgaaatctt tccatccgtt ctgtttacca gaaaggtcgg
     3301 cgcaacatcc cgcgcccagg aatcatcggt ctccatctca aagacaacca ccggatgtaa
     3361 gttttcttct tttttcagac tttccgcaaa tgcttttgca tggtcaatcc ccttttttcc
     3421 ggcagcgaca tacactgtct cactcgcggc gattgcacgg atcacagctg aaaacgctgt
     3481 ttctgcttcc ttcgcgccat ttctccagga accgggacgc tccggccaga tcatgataca
     3541 tccctgatgc tgctcaaact cacccggcat gaaaaatccg tcctgtaccg gtgttgtatc
     3601 ttttatcatc tcaggacagt ctgcctttga aatcttcata accaaactcc tttatcatct
     3661 cgacatctcc atcttcccgt aagactgcaa ttccgggcag cggcatcccg ttaaatgtat
     3721 tgtttttgac catggaataa attgccatat cctcaaagac cagacgatct cccacctgtt
     3781 ttttctgtgc aaagctgtaa tcaccgatca catccccggc aaggcaggtc atggaagaaa
     3841 gccggcaggt atgcggcttt tcgcccggca gataaccgtc ttttagcggc ggtctatatg
     3901 gcatttcaag cacatccggc atgtggcatg ccgccgatgc atccagaatc aggatatcca
     3961 ttccattgtg tacgatatcc ataacctccg tgacaagata gcccgcattt aatgcgatcg
     4021 cctcacccgg ttccaagtag acccggacat tatattttcg cctgatctca cagattaact
     4081 tctttaattc atccaactga tagtctgctc ttgtaatatg atgaccgccg cctaagttca
     4141 gccattttac ctgttttaaa taactgccaa acttctcctc aaacgcatgc caggtcgtga
     4201 tcagatcatc cgcattctgc tcgcagagtg tatgaaaatg taatccttcg attccctccg
     4261 gcagttgatc cggaaattca cttttaacca caccaagcct tgatcccggt ccgcatggat
     4321 catagatctc atgcccttcc tgtgtggagc actccgggtt cacgcggatc ccggcacttg
     4381 cagtgcactc ctgctgcaaa aaatagtgct gatacttttc atactgcgca aaggaattaa
     4441 aaataacgtg atcgcagatc tgcaccagtt cttccatatc tttttcctta taagccggtg
     4501 caaatacatg attttccttt cccatctcct cttttccaag gcgcgcctca aagattccgc
     4561 tcgccgtcgt tccgctgata tactgcccga tcagcggata cagtgaaaac atggaaaatg
     4621 ccttctgtgc cagaagcaca tggcagccgg tttcctgttc caaattctgc aatattttta
     4681 aattttgttt tagcttcttt tcatctacca cataacacgg ggtaggaatc tcctgccatt
     4741 tcatgataat tctccatttc tgcaaaaatc cgctgcgcaa aagctgacaa atttaaaatt
     4801 ttatccaacc cgtttcacac atattcttat tttatgccac cgtctgcgga ttttcgtcca
     4861 caacccatgg cagaccatac tggtttaaca tatccataaa cggatccgga tcaaactctt
     4921 caatattgaa tacaccgtct ttgtcccaga ctttatcgac aaccaacgct gcaccgatca
     4981 tagccgggac acctgttgta taagaaattg cctgggaacc gacttctttg taacattcct
     5041 gatggtcaca gacattatag atataaatcg tcttttcttt tccgtctttt tttcccgtaa
     5101 agatacagcc gatatttgtt tttccaaccg tgcgcggtcc taaagatgcc ggatccggaa
     5161 gcagcgcctt taagaactgg attggtacga tctccctgcc ctcatactcg atcggtgatg
     5221 ttgagagcat tccgacattt tctaaacatt tcatatgtgt cagatagctc tgtccaaagg
     5281 tcataaagaa acggatccgc tttactccag gtacattttt tgcaagggac tcaatttcct
     5341 catgatgcag cagatacata tctttctcgc caacctgtgg gaaattatat tctcttttaa
     5401 tttccattgg ttttgtttct acccagtgac cattctccca gtaagaaccg tttgcggaaa
     5461 cctcacgcag gttgatctcc gggttaaaat tggttgcaaa cggataaccg tggtcgccgc
     5521 cgttacagtc taagatatca atcgtctcga tctcatcgaa ataatgtttc agggcataag
     5581 cggtaaatac actggtcact cccggatcaa acccgcttcc aagcaatgcc gtaattcctg
     5641 cctctttgaa tttttcacgg tatgcccact gccaggaata gtcaaaatat gctgtaaatc
     5701 cctcttcttt acagcgtttt tcatagatgg cacgccattc tttgtcatcc gtatcctccg
     5761 gctcataatt tgcggtatcg atatagtcta ctttgcatgc aaggcaggca tccataattg
     5821 ttaaatcctg atatggcaaa gcaacattta acacagcatc cggctgatat tttttgatca
     5881 gggcgatcag ttcctccgta ttgtccgcat ccacctgtgc tgttgtgatg acagtgtccg
     5941 ttgttttttc cagtttctct tttaaggcgt cacatttcga ttttgttctg ctcgcaatgc
     6001 agatctccgt aaaagttttg ctgttctggc agcatttgtg aatcgcaact cctgcaactc
     6061 cgccacatcc gataattaat aatcttccca ttttaatctc ctttcctgcg ctgtcttttt
     6121 gcgcatctca agtttgtgcc ggggcacaaa tcttgcgtgt gaaaaaataa attttaattt
     6181 aatttttatt atttcttacg tccttcttct tcctctaaca tatcctccac atatcgcggc
     6241 agcataaatg ctcccttgtg cagattggtg gtataatacc aggtttttat cttccgctct
     6301 ttccagcgct ttgcatccag atcatcgagc ggatgatatt tctttgacgc aaacccgaac
     6361 agccagtatc cagaagaaca cgttggtata tgtgcctgat acacgcggct gattggaaag
     6421 ctatgactcg ctttccggtg cataccgcgg caggattcct catcttcatc gtaaaacgga
     6481 cttccatgct gatataccat gattccgtca tcttttaagg cacggaagca gtttccgtaa
     6541 aattccttgg taaacagtcc tgcagtatgt ccaagcggat caatcgcatc gttgatgatc
     6601 agatcatact cgtcatgttt catccgcaaa aatttcaatc catcctcata gtacaccgtc
     6661 acgcgttcat ccgataaccc gcatgcattg tccggaaaaa attccttgca gacctcgaca
     6721 aatacacggt ccggctccac gacatcgatc tgctctatct catcgtaata gccaagctct
     6781 cgtgccacgc cgccgtcacc gccgccgatg actaacacct ttttcacatg cggatgcacc
     6841 gccatcggaa catgcacgat catctcatca tagacaaact catctttttc cgaaaaaaca
     6901 atactaccgt cggaacttaa aaaacgccca aactcatccg aatcaaacac atcgatccgc
     6961 tgaaactcgg tctgtaaacc aaataactgt ttctgcacct tgaccgacac cttgactttt
     7021 tccgtgtggt aatccgaaaa ccaaagttcc atgatcttcc cccttctttt gaaaaaatct
     7081 tcttttcaca ggaatcttta tttttgctga tctatgctgt tatttctttg caagcacatt
     7141 cagattttca acttccggat cctccgttcc ctgcatagag catccctttt cttttgcata
     7201 aacaatgtac tcaatgatct ccggcgtgat catctcaccc ggcgctaaaa tcggaattcc
     7261 aggcggatag cacatgacaa attcaccgca gatccttccc gctgtctgac gaaccggcat
     7321 ggattccttt tgcgaataaa atgccacctg cggcgacact aaaaccttcg gattaatata
     7381 ttccgtattc agcatttttg ccggatcttt cgaatacagc cgtttgatgt ctgcaagtgc
     7441 acccacaagc cgctcaatat cctgtatccg gtcaccgatg gaaatatagg caagaatatt
     7501 tgcgatatct ccaagctcga tctgaatatc atattcatcc cgcagcagat catagacctc
     7561 aatgcctgca agcccgatat ctctcgtata tacagacagt tttgtcacat caaaatcata
     7621 gacactgcca ccgtttacca tatctttgcc atacgcataa aatccaccga tagaattgat
     7681 ctcatccctc gcgtactccg ccatctgtgc cactttcgca aaagattcct ttcctcgcag
     7741 ggcaaggttt ctccgcgaaa tatcaaggct cgacatcaga agataagatg cactcgtcgt
     7801 ctgcgtcaga ttgatgatct ggctgacata ttcccagttc acaccctttc cggtcagaag
     7861 aagagagctc tgcgtcaggc ttccccccga cttgtgcatg gagacagacg ccatatccgc
     7921 cccggcatcc atggcacata ccggaagatt ttccccaaaa tacagatgcg ttccgtgtgc
     7981 ctcatccacc agcaccagca tatgatgttc atgcgccact ctcacgatag accgcagatc
     8041 cgaacagatt ccatagtaag tcggattgtt gactaaaact gctactgcat ccgggttctc
     8101 caaaatcgca cgttccacct ctgacacctg cattcccagt gaaatgccaa gtctcacatc
     8161 gacctccgga ttgacgtaaa ccggaatcgc tccacagagc accagtgcat taatcacact
     8221 cttgtgcaca tttcgcggca aaatgatctt atcccctgcc ttacagcagg aaagcaccat
     8281 tccctgaacg gaggaagtgg ttccgccaac cataaaaaat gcatgttccg cgcgaaatgc
     8341 ctccgcggca agctcctccg cttccttgat caccgaaacc ggatgacaga gattgtcaag
     8401 cggcttcatg gaattgacat ccagactcac acatttttct cccaacagct ctaccagctc
     8461 cggatttccc cttcctctct tatgtcccgg cacatcaaac ggcaccactc ttcgtttttt
     8521 taacttttcc agtgcctcat aaaccggcgc acgcatctgc tgctctttgt ccatgactaa
     8581 aaaaatcccc cttggcttcc ataaaaatct gcatgctctg cttttcatca aatgtttttc
     8641 cctgacatta ccgtcaggct gaaaaacgca aaaaaagaac aggcatccat cacctgttct
     8701 tctatcgtcg ttatcatcat agtcatactt tatgtaatct atctacattc tgcaaaaact
     8761 attttctcca gagtccgcgt tggcatcttt gccagcaaat atttgcgtat actactctta
     8821 ttgaccgttt cacaagtgat attggattcc gggtatcatc cccgtaatca acttataaaa
     8881 tttgagcttc taactcaatc aataacgcgg cttacaccgc aatcggcagt tgccccgcct
     8941 gtccgtatgg gcttaaccaa tctcttggtg ggcaaacaat agatcctttt ccatctattg
     9001 taacgaatat ttgcatgaaa acaattttcg cattcatgtg atttgaagta tagcatacac
     9061 acatggcaaa tgcaataacg tattctgtaa aattctggta ttttcttttt tatttcgttt
     9121 taggacattt ttattttcta ttcaggtttg cagcgatctt accgcgtcca ctcccggacc
     9181 atctgtatct cccgtctgta cccctcatca tcgttcggtg tctctaagat aaacggtctt
     9241 ccttctaaaa gcgggtgcaa tgcaacgcgc cgcatcgcct ctgcaccgat ctttccctca
     9301 ccgatcttcg catgacggtc cttgtgggag ccacagtcgt tcatgctgtc attaaagtga
     9361 actgccttca gccggtcgag cccgatcaca cggtcaaact catttaacac atcgtcaagg
     9421 tcgtttacaa tgtcataacc gccatcccac acatggcagg tatcgaggca gactcccatt
     9481 ttatcgttta attccacacg gtctaagatt tctcttaact cctcaaacgt tcttccaacc
     9541 tcagttcctt ttcccgccat cgtctcaagt aaaacggtcg ttgtctgctc cggtttcaag
     9601 gcttcattta atgcttccgc aatcaatgcg atcccttttt ccgccccttg tcccacatgg
     9661 gaacccggat gaaaattata ataattgtac ggtgtatact ccatgcgttt taagtcatca
     9721 agcaacattt cctttgaaaa agaacggaca tcctcttttg cagcgcagag gttcatcgta
     9781 tatggcgcat gcgcaacaat ctttccaaat tcgtgctcct tcgcaaaatt taaaaacttt
     9841 tccacatctt tttcatcgat ttcttttgcc ttaccgccac gcggatttct tgtaaaaaaa
     9901 gcaaaggtat tggcatctaa cgccagcgct gcctttccca tcgccgcata tcctttggat
     9961 gcggataaat gatttcctat taacatatca atcctcattt ctgcactgcg cttcgcgcac
    10021 cttaattttg tgcacaataa tactcctgtc tgtatacgcg aatgctcttt tattctgccc
    10081 ggttcttctc cacgatcgtg cccgctctgt atgccgcgag cagctcctca agatcatgga
    10141 tcgactcttt taaacttttt ccgatatctg tatcggcaac cgtttttctc cgcacgacct
    10201 gctgcaccag aaccgtatgg gatacgatat cgcttccgtc ctgcaccgct ttttctaccg
    10261 attcaaacgg ttcatgcgcc gcaagcacca gaccataaga attataaatc agcgtatatc
    10321 cggcaatccc cgtctttggc tgatatgcct tggaaaaacc gccgtcaatg atcagaagct
    10381 ttccgttaca tttgaccgga gactctcctt tttttgcctc caccggaata tgaccgttaa
    10441 tgatgtgcgc ctccgcacct tcaagcccga attcctctaa aatccggttg accacttcct
    10501 ctttttcaag cagcctgtaa taaggatttt tcggctcctg atgcgttatt ttatctgcaa
    10561 taaaataacg ctcaaacgtc gtcatctttg cctttccaaa caccggggaa ttctggtttt
    10621 cccagataaa ccataaaatg tcctgtccct ttttcttctc cttcgggtcg atcgcataat
    10681 agccttttcg cgcatagccc tcaagcacat cataaagctc ttttccggca tattcttttc
    10741 caaaaacgtt aactctggta aacgtgccat cctcattcag cggcacgcat ccatgataga
    10801 gaagatttcc attatatact ttgtaaagac ttccctgtgt atacaaaaaa cgcacatgac
    10861 gctgcagttt ttcacagttc acaaatgcag tcacaagacg ctccatcaca tccgcctcat
    10921 cttctgagag acgatatgga tcttcccagt cgattgtcgg aaaactgaca tccttgagcg
    10981 gatactcggt ttcctccaca cacacggtcc ccttttcgat gttgatctta tcgagaagaa
    11041 gtcttttctc catctcaaat tccgggtttt ctttgatcag ctgaccttcc agtttaaact
    11101 gcatgatcgt gatcgcctta tgcatttttt catctaaaaa tgcgtcgtgc acatcatatt
    11161 catcttcccg gtaatccagc ttaaaacagt cacaggaatc cttatcatac cacttcatcg
    11221 caaatcttgc cagcggcacc agattaatcc cgtaaccgtc ctctaacaga tcaaggtttc
    11281 catattttgc agaaatgcgg atcacattac agatgcatgc cgcactgccc gacgccgctc
    11341 ccatccagta cacatcgtga ttgccccact ggatgtccac agagtgatgc tccatcagtg
    11401 tgtccatgat cagattcgga tatggtcccc tgtcaaaaat atccccgacc acatgcagat
    11461 gatccacaac aagccggcgg atcagattac agaacgcgat cacaagctcc gccgcccttc
    11521 cggtgcggat gaccgaccgg ataatttcat tataatatgc ctcctgatcg gatatctcct
    11581 gtctgccggt caaaagttcc tcgatcacat aggcaaagtc ttttggaagt gctttgcgca
    11641 cctttgatct tgtatacttg gaagatgcat ttttacagat gcggatcagg cggtataagg
    11701 tgactttgta ccagtcctcc aaattatctt ccgtctttaa cacctgttcc aacttctgtt
    11761 ccgggtaata gatcagcgtg gcgatcgctt ttttctccgc cgcgctgatt gcattgccaa
    11821 attcatcctc tattttccgc ttgatggcac cggatccatt ttttagcaca tgtaaaaact
    11881 ggtcgtactc cccgtgcaca tctgtgataa aatgttctgt tgcttttggc aggctaagaa
    11941 tcgcctgtaa attgataatc tctgtcgccg ctgtggcaat ggtcggatac tgatttgata
    12001 aactttttaa ataacgcagg tcggtctgcc ccatagtatt cctcatttct ttttcacgtt
    12061 catttgctgc ttttttatct tagcatagga aatgagcggg ggcaaccaac gttaatttat
    12121 tgtcaatgct ctacgcgatc gtagccttga tcacatcccc catatcatag aatcccgccg
    12181 gttttccgga caggaatttt gccgcctgca cagcgccctt tgcaaataca cttctggaat
    12241 atgcagtatg cttaaactcg atcacctcgt caagtcctgc aaagatcacc tcatgttctc
    12301 ctacgatgct gccgccacgc actgcagaga taccaatctc tgttttttct ctctttttgc
    12361 gctctttgct gcggtcataa gtataggtat atgcattgcc aagcgcctca ttcatggaat
    12421 cggcaagtgc aagtgccgta ccgctcggcg catcaagttt ctggttgtag tgtttctcga
    12481 cgatctccat atcaaaaccg gccggtgcta aaatggttgc agcctgtttt aacagctcca
    12541 ttaacatatt gattccaagc gacatgttgg cagattttaa tacggcaact tttttcgatg
    12601 ccccgtccac cttttttaac tgctcctcag aaagtcctgt cgtgcagagt acgaccggga
    12661 tctgcttgtc cacgctgtat accaaaagat catccactgc ctttgcattg gaaaaatcaa
    12721 tgatcacatc cgctgccaca tcacagacag agatattggg gaataccggg taatcgtttt
    12781 tgatgccatc gtagagatcg attcctgcca cgatctcaat ctctgcatcc tccttgcaga
    12841 tccctgtgat cacctgtccc atttttccgt tacatccact cataattgct cttatcatgt
    12901 tgtttttcct ctcttttctt tatttaaagc aacaccggaa acgctgcaaa ccaacatttc
    12961 cggtgttttt tcaaatctgg ctttccgtgt tccactgccc cttacgccag cttgatccca
    13021 taattcttca ttgcttccgc aagttttgca gcattggcat ctgtcatctc tgtgagcggg
    13081 gaacgaagcg gtcctgcctc catgcccatc agattcagcg ctttcttaac agggatcggg
    13141 ttcacttcgg agaacagcgc ctcaatgagc ggctgtgcct ttagctggat ctccattgct
    13201 tttttcgtat ctccgtcaaa gaatgccata cacatatcat gtacatcctt cggtgccacg
    13261 tttgaccata cggagatcac accgattgct ccgatcgaca ttaacggtac tacgattcca
    13321 tcctcgccgg aatacagatc aagctttcca tccgttaaat acatggtctt tgctgcctgt
    13381 gcaacatttc cggttgcctc tttgatcgca acgatgtttt caacatcatg gtacagtttt
    13441 gcagctgtct ccggaaggat attgcatccg gtacggcttg gaacattgta catgataata
    13501 ggaagtttta cagaatttgc aatctctgtg tagtagcgga tcagacctcc ctgtgttgct
    13561 ttgttataat atggagttac gcagagcagt ccatccacgc cggctttttc cgcttcttcc
    13621 gaaaggtgga ttgcctctct ggtacagttt gaaccggttc ctgcaacgac cggaatacgg
    13681 tgttttgcaa atttaacagc agctttgatc acctctgcat gctcttctgt cgtcagcgta
    13741 gagctctcac ctgttgtacc tgcgataatg atacagtccg ttccctgatt gatctgatac
    13801 tcgatcatct gctctaatct gtcataattt acttcctcat tgtttttcat tggtgttacg
    13861 attgccacac cggctccttt aaaaatagac atattaataa tcctcctggt tcctgtatta
    13921 tgatacgtta ggatacactg ctttgtgcac acggtatttt atttattcat aggacgtaat
    13981 ttccctatga attaaaaaaa ccgactctga tgagccggtt cgtaaattct aatcatatgt
    14041 attacccagt atatgtcgaa tccgatagcg ccccatcttt ctgccatttc agcttaagat
    14101 gacagtcata aggttcttta ccttatgccc aggaacatat ccgcagcaaa tatactcctt
    14161 cggcgttctt tccttttatc ctccatcctc tgcttctgcc acatccggaa aactactctt
    14221 aaagcacgca acctctatca agcaatatgt atcttttagc aatcatagca ccatctattt
    14281 ctactgtcaa tccaattcct ctaaaaaatc aattttgctg acggatactt cgtatgcaac
    14341 ccttttttcc gtctgcgtct ccgataattt tttgacatat tcgcggctct ggatcctgcc
    14401 ccagatctgc acatgtccgc ccacatcaaa accggaggca aatcttgcat ttcgtcccca
    14461 gcagatgcac ggaatgtaat ctgattttcc ataagagcgg ttcacagcga tcagaagatc
    14521 tgcgatctct cttccaagcg gtgttttccg gtaaattggc tccttacata catagccgtc
    14581 taaaaagatc tggttgctct ttacctcatc gtcaatctcg tctaaaaatt ccagttctct
    14641 cacaaaaacg gaaagtacaa gccggttttt cttttcctcg tgccggttga atgagcggaa
    14701 ctgtcctgtc acataaatat tctgtccgac catgtcctca ttgacatcga tcaatcgttc
    14761 cgaaatcatc aatggtatgt aatccatata attgctgaga cggttgactg ccacgtcgac
    14821 catataaaat ccctctccgt acacttcgtg gctgaaccgg aaatccgata caatctcccc
    14881 cacgatcgac acctggttgt tttcaaacat tttatctgcc atgaatattc tcccttcctt
    14941 gcggtcatac acctatatat ttttttgtgc gttttttctt ttcgaaccgt ttctgcccgg
    15001 tatgacctgc ctgacataat atttttacca tgtatcacat tcaaattttc atggaacatg
    15061 tcgataagaa aacgaatgta atgacaactt ttgtcaggtt tttgaataaa aaaatattgc
    15121 agaattccac aaatatgata aaatatatag gttggttttt taaccttatg ttacagttaa
    15181 tacatttcac acaggaaaga gagattttgt atatgaaaat gaaacgtgaa gatgtccgta
    15241 atattgccat tattgcacac gttgaccacg gtaaaacaac tctggtcgat gagctgctaa
    15301 agcagagcgg cgtattccgc gcgaatcagg aagttcagga acgtgtcatg gactccaatg
    15361 atatcgagag agaacgtggt atcacgatcc tttcaaaaaa cacagccatt acctataaag
    15421 gtacaaagat caatatcatc gatactcctg gtcatgcgga ctttggtggt gaggttgagc
    15481 gtgtccttaa aatggtaaac ggtgttatcc ttgtcgttga cgcattcgag ggtgttatgc
    15541 ctcagaccaa attcgtactg atgaaagcat tagaactttc tcttccggtt atcgtatgtt
    15601 taaataaagt agaccgtccg gaagcccgcc cgaacgaggt tgtcgatgaa gtacttgagt
    15661 tattcatgga cttagacgca tccgatgagc agttagactg tccgttcctg tttgcatctg
    15721 caagagacgg ttatgccgtt cgcgagatcg gagatcttgt aaataacaaa aaagatatga
    15781 cacctctgtt tgagaccatc attgattaca ttccggctcc agaaggggat ccggatgcaa
    15841 acacacaggt actcatcagt accatcgatt acaacgagta tgtcggacgt atcggtatcg
    15901 gtaaagtcga caacggatgc ttaaaagtaa atcaggaagc tgttgtggta aaccatcatg
    15961 aaccggacaa acagaaaaaa gtccgcatca gcaaattata tgaatttgac ggcttaaata
    16021 aagtagatgt cgcagaagca aagatcggat cgatcgtagc aatctccggt atcgcagata
    16081 tccacatcgg agatacgatc tgtgcaccgg aaaatccggt tgcaataccg ttccagaaga
    16141 tttctgagcc tacgctttcc atgaacttca tggtaaacga cagcccgctc gccggacagg
    16201 aaggtaaatt catcacttcc cgccatttaa gagaccgtct gttcaaagaa ttaaataccg
    16261 atgtttctct gcgtgtagaa gagacagaga gtccggactg ctacaaagta tccggccgtg
    16321 gtgagcttca cttatccgtt ttagttgaga acatgcgccg tgaaggttat gagtttgcag
    16381 tcagcaaagc agaagtttta taccacacag acgagaacgg taaaaagaca gagcctatgg
    16441 agatcgctta cgtcgatgtc ccggatgagt ttaccggtac tgttatcgat aaattaagcc
    16501 agcgtaaagg tgagcttgtc aatatgaaac cgatcaccgg cggttacacc cgtctggagt
    16561 ttaatattcc atcccgtggt ctcatcggtt accgtggaga tttcatgaca gacaccaaag
    16621 gaaacggtat catcaatacc attttcaacg gctatgctcc ttaccgtggt gagatcgcat
    16681 accgtaaact tggttccctg atcgcatttg aatccggcga atccgtaact tatggtctgt
    16741 tctctgccca ggaccgcggt actttattta tcggacctgg cgaaaaagtt tatgccggaa
    16801 tggtcatcgg ttcctgtgca agagctgagg atatcgagtt aaacgtatgt aagaaaaaac
    16861 atcttaccaa tacacgttct tcttctgctg atgaagcact gacactggtt ccgccaaaag
    16921 ttttaagctt agagcaggcg cttgacttca
//
