LOCUS       c00104_gnlPro..        15409 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DGCEBJHE_104.
ACCESSION   c00104_gnlPro..
VERSION     c00104_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 16:52:55
            Original ID  :: gnl|Prokka|DGCEBJHE_104
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3863
            Orig. end    :: 19272
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15409
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[13863:19107]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15244
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..15409
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15409
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(232..501)
                     /locus_tag="ctg104_6"
                     /transl_table=11
                     /translation="MCRADLTERAAEEKDMLVLAKEEENIVVNKPALSQIRSICELATL
                     ECYYHNVEKSAKTKGTGLAHVGEKEKNSGSNTPELLRLKSTCRM"
     CDS             complement(718..2379)
                     /locus_tag="ctg104_7"
                     /transl_table=11
                     /translation="VLTNGETFSYDKNEIESYVVTGLKYVPVKVKTEDYEAFKAAYTVV
                     ENGSTLSGGFSEGNLKNYTDLVAEVTENTNGLKTVTQNEDGSFSFAARVNNGTDSGIKY
                     AALKTAENITTTVKEASGSYGEFLRVDLTGEGYGALGADMQAVEWTYYGSDSTYTDPLQ
                     SYGTKFASDNWMHKAQGIQLGLTDSLRCKLPAGTDGTGYWTITVYALGYNDYTVKFKVT
                     DANIVKDEEETVDTTALEAAIKSAENLTESDYTAASWSDLCVELKEAKDELAAPHTQST
                     VDEATEHLNAAIKALVKAETKEETKTDVTKLNAVIEKAEALKQSDYTAESWKNLQTALD
                     AAKKLTDATAEQTVVDQAASDLETAILALVKADTENTGTTDKKKKPAVGTVKTVGQIKY
                     KVTGKNTVTVNKYAKKNITKASIPATVKINGYTFKVTAIADSAFSGCSKLTKVTVGSNV
                     KAIGNKSFYKCTKLTTFTASSTGLNKIGKEAFSGDKKLANITLKTTKLKKSGVGKDAFK
                     NIKKNATFKVPAKKVSDYKAIFKSKGAGKKIKVKKL"
     CDS             complement(2373..2720)
                     /locus_tag="ctg104_8"
                     /transl_table=11
                     /translation="MKRKNVSARILTGVLAFSMVAATGTSSMTVFAAEESAVEAEQITG
                     TEVKSETGETQEYQYAYAALSLTRVHLIPYREQPPITDCTGEVISVRQKLQKKMVQSSK
                     WHIIQEQPPVC"
     CDS             complement(2798..3334)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg104_9"
                     /sec_met_domain="Fer4_4 (E-value: 0.00039, bitscore: 11.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTAALSLIKYAVRLLILFLCFGGTYVKLKGSSPWDVFSMLHAG
                     NFALEGYFAGVVLLILILCGMCVQERFFCRILCPMGAIFSLLPVLPYFALRRERENCIS
                     GCAACTKKCPSDIGLPELGSIETRGDCFMCQKCTGICPKGNIHCGVSGKLKGNELWFTA
                     IRAVFLLFLYLWIGI"
     CDS             complement(3374..3733)
                     /locus_tag="ctg104_10"
                     /transl_table=11
                     /translation="LESTKLKNIAEIIQKNCISKERKTNGAVFWKKHKKQIPAWIRAGI
                     QLLFFVFFPSAFTAAFSGVKYIAGQMGTGAQIEITSFVLSLIILCASTVVFGRFFCGFA
                     CAFGSLSDWVRAAYV"
     CDS             complement(3748..4185)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMN_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg104_11"
                     /sec_met_domain="FMN_bind (E-value: 5.1e-17, bitscore:
                     52.9, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDFLIRSFCLAAVILILAGYNQVLKDRSKDEEITKLEVQVTKLQ
                     QEKEKTVDIKGTYPDGRWEGGAKGFGGMITVLVTVENGTISEIEITSADGEDKAYLSMA
                     EDIIPKIIEAQSADVDTVSGATFSSTGIRDAVSEALKQAEQ"
     CDS             complement(4199..5902)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FMN_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg104_12"
                     /sec_met_domain="FMN_bind (E-value: 1.3e-16, bitscore:
                     51.6, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNISGIVPVILAAVVGIGAVVSLSDYTASVYGSESEDELTETET
                     IIESAGMESVEETEVENTEAAAVLDGAFDLADGTYEGSANGFSGKIKVSVVIKNQTIRS
                     INILSNSDDAAFFNRAKEGVIAGIIAKQSTDADTVSGATYSSRGIINAVKDALSSSDGE
                     EQTVVAKGDFALNDGYYEGTGNGFAGPVKLFIEIKDKSIIGIYIVKISDDAGFFNRAKE
                     GVTASILEKQSTDVDTVSGATYSSRGIIEAVSNAMEAAKKAKKGETDTETEDDTEKPDT
                     SKASSYYGVVVCNPDESGAFTAYNLHVKVMFQNGKIIAVSDVYGDGDSQNDTYITKAVS
                     GSSKHPGVVTQIVNKNGIDGVDTVSGATCTSKAVLHAVDVVVKAAAKDGNYTFSGSQSC
                     DDDTKNSEDTEKDSEDTEKNSENTENNSENTENNSEDTENSSENTESGGDTEKNDTENT
                     ENSGETTLIYKNGDYKVSVVCIPDEDEDFDEYKLTLTLVIENDQIKEIKDISGDGGKSN
                     SFYIKTASKGVVSQILQKNSTEGIDTVSSATCSSKAIIEACQKALEQAKN"
     CDS             complement(5929..6969)
                     /locus_tag="ctg104_13"
                     /transl_table=11
                     /translation="MSEGKVKRKIIFLIFAAVMVVAGGCGTDGGDTEASRDLFAMDTYM
                     TVTAYGKGATEAVDQAADEISRLDQLLSTGNEDSEIYKINQSGDGILSEETAYLVERSL
                     DLYEATDGAFDIAIYPVMKAWGFTDDNFRVPGADELKDLLTLTDASDISYDKETSQIAF
                     KKDGMQIDFGGIAKGYTSARIMDIFRACGIKSGLVNLGGNVQALGTKKDGSSWRVAVQD
                     PQDTDQYLRVLSIQDKAVITSGGYERYFEQDGRTYHHIIDPKTGYPVENGLISVSIVTA
                     DGTLADGLSTSVFIMGKEAATEYWRNHSDEFDMILMTDDREIYVTEGIADSFESEMDTK
                     IIEKKV"
     CDS             complement(7165..7848)
                     /locus_tag="ctg104_14"
                     /transl_table=11
                     /translation="LRNEHASVILNNVVKLHITRKEEETMTQKKFSTKYLVEMALLVAI
                     ILIMAFTPIGYIRTAGLEITLIVVPVAVGAVTLGPAAGAILGGVFGVTSFIQCFGMSPF
                     GAALLGINGFLTFLVCVPTRILMGWLTGLIYKGLRKTKLPSGASVTISNLCCPLLNTTF
                     FMGMLVIGFYNTEYIQSFVSALGAKNALLFILAFVGVNGLVEAIVCFVVGTAISAALKK
                     ALKYN"
     CDS             complement(7919..8527)
                     /locus_tag="ctg104_15"
                     /transl_table=11
                     /translation="MNKKKFSTKFLVEMALLVAIILIMAFTPLGYIKTAGIEITLIVVP
                     VAVGAVTLGPAAGAILGGVFGLASFLRCFGLNAFGAMLLSINPFLAFLLYVPTRILTGW
                     LTGLIYQGIRKTKIPSNVSITIANLCCPLLNTTFFMSMLVFGFYQTEYIQSFVQTLGVS
                     NPFLFVIAFVGINGLVEAVVCFIVGTAISAALKKALKYS"
     CDS             8830..9444
                     /locus_tag="ctg104_16"
                     /transl_table=11
                     /translation="MIQKKNVLNTVPIICLGALLLGAAYGQLHTPMTPPPITALASDIL
                     PTTGNVRALVVVVDFADAKYDTDRRLSDEEISSYLFGTDNTEFYPCESLTSYFDRASYG
                     SLHMTGNVFHYTAKGTIASYEKTNDGYETLVREVLSGLNDTIDYTDYDSDGDGYIDALC
                     LSVPSRGNADFWYGCTASWWASTLPDLDGEKLRKLSDHTAH"
     CDS             complement(10001..11047)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 161.3;
                     E-value: 7.7e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_17"
                     /sec_met_domain="ETF (E-value: 2.7e-50, bitscore: 161.3,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 1.2e-38, bitscore:
                     121.7, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALEEYKGVFVFAQQVDNVLDGVAFELLGKGKDLAKDLGTDVTAV
                     LIGSGVKGLADQLAEYGADKVIVVDDPELKDYRTEPYAHALASVINEFKPEIMLVGATA
                     IGRDLGPTVSARVKTGLTADCTSLEIGDFPLVAAPGKESEQKHNQLLMTRPAFGGNTIA
                     TIACPDNRPQMATVRPGVMQKIAPISGAKANVVEYNPGFTPNNRYVEILNIVKAVKSTA
                     NIMEAKILVSGGRGVGSKENFKLLEDLAEVLGGTVSCSRAVVENGWLPVDLQVGQTGKT
                     VRPQIYFAIGISGAIQHVAGMEDSDLIIAINKDEDAPIFDVADYGLVGDLNKIVPALTT
                     ALKAELGK"
     CDS             complement(11074..11856)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 159.1;
                     E-value: 3.7e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_18"
                     /sec_met_domain="ETF (E-value: 1.3e-49, bitscore: 159.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVVCIKQVPDTKGGVKFNPDGTLDRAAMLAIMNPDDKAGLEAA
                     LRIKDETGAKVTVLTMGLPKADAVLREALAMGADEAVLVTDRVLGGADTWATSTTIAGA
                     LRNLDYDLIITGRQAIDGDTAQVGPQIAEHLGLPVISYAADIKVEGDSVVVKRQYEDRY
                     HELKAKMPCLVTALSELNEPRYMTPGGIFDAFDKEVTVWGRADLKDVDDSDLGLKGSPT
                     KIAKASDKVAKGAGEKVNLDPAESVAYLIGKFKEKHII"
     CDS             complement(11913..13067)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_19"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.2e-52, bitscore:
                     168.6, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.5e-31, bitscore:
                     97.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.5e-40, bitscore:
                     126.6, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLDKKHEMARSLFKEFAETEVKPLAQETDETEAFPAETVKKM
                     QKYGFMGIPVPKEYGGQGCDPLTYVMCVEELSKVCATTGVVVSAHTSLCIDPIMTYGTE
                     EQKQKYVKPLATGEKLGAFALTEPGAGTDAQGAQTKAVLDGDEWVLNGSKCFITNGKVA
                     DVYIVIAITSITEDKRGRKKKNFSAFIVDKGAPGFSFGTKEKKMGIRGSSTYELIFEDC
                     RIPKENLLGPEGKGFPIAMHTLDGGRIGIAAQALGIAEGALDRAIAYTKERKQFGRSIA
                     QQQNTQFKLADMAARIEAAQLLVYKAAMAKATQKVYSVEAAKAKLFAAETAMAVTTEVV
                     QLFGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGALLK"
     CDS             complement(13097..13969)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_20"
                     /sec_met_domain="HCDH (E-value: 3.7e-35, bitscore: 111.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 1.8e-63, bitscore: 204.2,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGQGIAKAFAQVEGYEVALCDIKQEWAEGGKEKIK
                     KGYARLVEKGKMTQEAVDGILAKITPGLKEDLCKDCDLIVEAAFENMEVKKTTFKELDE
                     IAKPDCIFASNTSSLSITEIGNGLNRPMVGMHFFNPADRMKLIEVIAGVNTPDETVAAI
                     KKISEEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYKETGDSKYRACPLIRKMVRGGNLGAKSGKGFYVYNAD
                     RTKTPVDAQ"
     CDS             complement(14063..15244)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg104_21"
                     /sec_met_domain="Thiolase_N (E-value: 9.9e-98, bitscore:
                     317.1, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 1e-50, bitscore:
                     161.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKVVLAGACRTAIGKMGGALSNTPAADLGAIVIKEALRRANVK
                     PEMVDEVKMGCVIQAAQGQNVARQAAIKAGLPIEVPAITINVVCGSGLKCVNDAATMIM
                     AGEADIVVAGGMENMSMAPYAMTKARFGYRMNNATIIDTMVNDALTDAFNHYHMMITAE
                     NVCDKYGITREELDEFSANSQQKCEKAIAEGKFDDEIVPVPVKVKKEIVDFVKDEGPRA
                     GTTAESLAKLKCCSGKEGGLVTAGNASGINDGAAAIVVMSEEKAKELGVTPMATWVAGA
                     LGGVEPEIMGVGPVASTRKVLAKTGLSIDDMDLIEANEAFAAQSIAVARDLKFDMSKVN
                     VNGGAIALGHPVGASGCRILVTLLHEMQKRDAKRGLATLCIGGGMGFSPIVER"
     CDS             complement(15259..15408)
                     /locus_tag="ctg104_22"
                     /transl_table=11
                     /translation="FKMKEKKINFNRKFEFIFLKKIVKKLTAFFGNFKEKETNSLQKQS
                     FVLN"
ORIGIN
        1 gccagtcagc ttccatgatc ttctcattaa attcttttcc gtgctctgcc caggtaactc
       61 ccactgaaat gctaatattg ttgttcatca tttcacagac agatcttaca ttatcataaa
      121 attgcgtttc tgtcgtatcc ggatcaaata ctgcaatgcc aacctgaaac tgatccatac
      181 tctgatattt ttctatttcc tcattgtatc tgttacgatt atctttcata tttacatccg
      241 acatgtcgat ttcagtctta gcaactccgg tgtattcgat ccagaatttt tttctttttc
      301 tcccacatgt gccaatccgg taccttttgt tttcgcggac ttttccacat tgtgataata
      361 acattctagt gttgcaagtt cacagatcga ccggatctgt gatagggcag gtttattgac
      421 aacaatattt tcctcttcct ttgccagcac aagcatatcc ttctcttctg ctgcacgctc
      481 tgtcagatcc gctctgcaca tttcatacgt ttcctgcgat atcgtttctg tttcatattt
      541 ttattttcaa aaatataatc catagaacca aaacctaccg ccatgttctg tatctcactc
      601 tccggaagtg tgagggtgat tgtttttgtt tcctcctcaa aggttcaatt acacattcca
      661 ttctacaata aggtctcttc accccctgtt tttttaacaa aagaatattt tttcacccta
      721 cagtttcttt accttaattt tttttccagc accctttgac ttaaaaatag ctttataatc
      781 agaaactttt tttgccggta ctttaaaggt tgcatttttc ttaatgttct tgaatgcatc
      841 ctttccaaca cctgattttt tcagttttgt tgtctttaat gtgatatttg caagtttttt
      901 atcaccggaa aacgcttcct ttccaatctt gtttaatccg gtagaagatg ccgtaaatgt
      961 ggtaagtttt gtacatttat aaaatgattt atttccgatt gcctttacat tagaaccaac
     1021 cgtaactttc gtaagtttac tgcatccgga aaatgcgctg tctgcaattg cagttacctt
     1081 aaatgtatat ccgttgattt taaccgttgc aggaatagat gcctttgtaa tgtttttctt
     1141 tgcatattta tttacagtta ctgtattttt tccggttact ttatacttga tctgtccaac
     1201 tgttttcaca gttccaactg ccggtttttt ctttttgtct gtagttccgg tattttccgt
     1261 atcagctttt accagcgcca aaatcgctgt ttccagatca cttgctgcct gatctactac
     1321 agtctgttct gctgttgcat ctgtaagttt ctttgcagca tcgagcgcag tctgtaaatt
     1381 tttccagctc tctgctgtgt aatcactctg ctttaatgcc tccgctttct cgattacagc
     1441 gttaagtttt gtaacatctg tttttgtttc ttcctttgtc tctgccttta ccagtgcttt
     1501 gattgcagca ttcagatgct ctgttgcctc atctacagta gactgtgtgt gcggagccgc
     1561 aagctcatct tttgcctctt tcaattcaac gcaaagatca gaccagcttg ctgccgtata
     1621 atcactctca gttaagttct ctgcactttt aattgcagct tcaagtgccg tcgtatccac
     1681 cgtttcctct tcatccttaa caatatttgc atcggttacc ttaaatttta ccgtgtaatc
     1741 attgtaacca agtgcatata ccgtgattgt ccagtatccg gttccgtctg ttcccgccgg
     1801 cagtttacaa cgcagtgaat ctgtaagacc aagctggatt ccctgtgctt tgtgcatcca
     1861 gttatctgat gcaaacttgg ttccataaga ttgaagtgga tcggtataag tactgtcgga
     1921 tccataataa gtccactcta ctgcctgcat atcagcacca agtgcaccgt agccctcccc
     1981 agtcagatcg acacgaagga attctccgta agaaccgctt gcctctttta ccgttgttgt
     2041 aatattctct gctgttttta atgcagcgta cttgattccg gaatccgttc cattgtttac
     2101 tctcgcagca aacgaaaaac ttccgtcctc attttgggta actgttttta gaccattggt
     2161 gttttctgtt acttctgcaa ccagatccgt atagtttttc agatttccct ccgaaaatcc
     2221 accggataaa gtactgccat tttccactac ggtatatgct gctttaaaag cttcataatc
     2281 ttcagttttt actttgactg gaacatattt aagtcctgtt accacataac tttcaatctc
     2341 atttttatca taggaaaaag tctctccgtt cgtcagcaca ccggtggctg ctcctgtata
     2401 atatgccact ttgagctttg taccatcttt ttttgtaatt tctgacgtac actgataact
     2461 tcccctgtgc agtccgtgat tggtggttgc tctcgatacg gtatcaaatg cacccttgtc
     2521 aagctcagcg ctgcataagc atactgatac tcctgcgttt ctcccgtttc actcttcacc
     2581 tcggttccag tgatctgctc tgcttccact gcactttctt ctgcggcaaa aaccgtcatg
     2641 gacgatgtcc ctgttgctgc caccatggaa aaagccaata ctccggtcag aatccgggca
     2701 gatacatttt ttcttttcat tttttaaatc ctccttcatt tagctttatc tatcaaaagt
     2761 tagtttttgc taactctcaa tcaaaaaatt cacactatca gattccgatc cacaggtata
     2821 agaaaagcag aaataccgcc cttatggcag taaaccacaa ttcattcccc ttcaattttc
     2881 cagagacacc acagtggata tttcctttcg gacagatgcc ggtacatttc tgacacataa
     2941 aacagtcgcc tctcgtctca atcgacccca gctccggcag tccgatatcc gagggacatt
     3001 ttttcgtgca tgctgcacag ccagagatac agttctccct ttctcttctg agcgcaaaat
     3061 atggcagtac tggaagaagt gaaaatatcg ctcccatcgg gcacaaaata cggcagaaaa
     3121 aacgctcctg cacgcacatg ccacacagga tgagaatgag caggacgact cccgcaaaat
     3181 atccttccaa tgcaaaattt cctgcatgaa gcatggaaaa gacatcccac ggactgctgc
     3241 ctttcagttt cacataggta cctccaaaac acagaaaaag aatcagcagt cgtacggcat
     3301 acttgatcag tgataatgct gccgtaagtt ccatgccaag cgtgaccggt ttctttttta
     3361 attttttaca gactcagaca taagctgcac gcacccagtc cgacagactt ccaaatgcac
     3421 aggcaaatcc acagaaaaaa cggccgaaca ctacggtaga tgcacagagt atgataagcg
     3481 acagcacaaa tgaagtgatt tcaatctgtg cacccgttcc catctgtccg gcaatatatt
     3541 tcacaccgga aaatgcagcc gtgaacgctg acgggaaaaa tacaaaaaac aataactgta
     3601 ttcccgcacg gatccatgcc ggaatctgct ttttatgctt cttccagaaa acagctccat
     3661 ttgtctttcg ttcctttgat atacaatttt tttgaattat ttcagctata ttttttaact
     3721 tcgtactttc caaatttttc ttcactctta ctgttctgcc tgtttcagtg cctcgctgac
     3781 agcatccctg atcccggtag aactgaacgt tgcaccgctt acggtatcca catctgcgga
     3841 ctgcgcctct atgatctttg gaatgatatc ttccgccatg gataaatagg ctttatcctc
     3901 gccgtctgcg gaagttatct caatttcgct gattgttcca ttttccacgg tcacaagcac
     3961 ggtgatcatt ccgccaaaac cttttgcccc gccttcccat ctgccgtccg gataagttcc
     4021 ttttatatcg acagtttttt ctttttcctg ctgcagtttt gtcacctgca cctctaactt
     4081 tgtgatctct tcatccttgc ttctgtcctt taatacctga ttgtaacctg ccagtatcaa
     4141 tatgaccgca gccagacaaa atgaccggat caaaaaatct ttcatctgct attctccctt
     4201 aattttttgc ctgctccaat gccttttgac aggcttcaat gattgctttt gaggaacagg
     4261 ttgcagacga taccgtatcg atcccttctg tactgttctt ttgtaatatc tgactgacaa
     4321 caccttttga cgcggttttt atatagaatg aattgctctt tcctccgtct ccggaaatat
     4381 ctttgatctc cttgatctga tcgttttcga tcacaagcgt gagcgtcagt ttatattcat
     4441 caaaatcttc atcctcatcc ggaatgcaga caacactgac cttataatca ccatttttat
     4501 agatcagcgt tgtctcgcca ctattctcgg tattttccgt atcatttttt tcagtatctc
     4561 cgccactctc agtattttca ctgctatttt ccgtatcctc gctgttattt tccgtatttt
     4621 cgctgttatt ttccgtattt tcgctgttct tttccgtatc ctcactgtct ttttccgtgt
     4681 cttcgctgtt ctttgtatcg tcatcacagc tctggctgcc agagaacgtg tagtttccat
     4741 cttttgccgc agcttttacc accacatcca cggcatgcag tactgccttt gatgtacagg
     4801 ttgcaccgga gaccgtatcc accccgtcaa ttccgttttt atttacgatc tgtgttacaa
     4861 cccccggatg cttactactg ccggaaaccg cctttgtaat ataagtatca ttctgggaat
     4921 ctccatcccc gtacacatcg gaaactgcaa tgatttttcc attctgaaac atcactttta
     4981 catgcaggtt gtacgccgta aaagcaccgc tctcatccgg gttacagaca acaactccat
     5041 aataggagct cgcttttgat gtgtccggct tttcggtatc atcttctgtt tcggtatccg
     5101 tctccccctt tttcgctttt tttgcagcct ccatcgcatt tgatactgcc tcaatgattc
     5161 ccctcgaact atatgttgca ccagaaactg tatctacatc cgtgctctgc ttttctaaaa
     5221 tacttgccgt cacgccctcc tttgcacggt taaaaaatcc tgcatcatct gatattttta
     5281 caatataaat cccaatgatc gacttgtctt tgatctcgat aaacaatttg accggtccgg
     5341 caaatccatt tccagttcct tcataatagc catcattcaa cgcaaaatct ccctttgcca
     5401 caaccgtttg ttcttccccg tcactggaag ataacgcatc ttttactgca tttatgattc
     5461 ctcttgaact gtatgttgca ccggaaaccg tatccgcatc cgtactctgt tttgcaataa
     5521 tgcctgctat cacaccttct tttgcacgat tgaaaaaggc tgcatcatct gaattactca
     5581 aaatgttgat cgaccggatc gtctgatttt ttatcacaac tgaaactttg atcttaccgg
     5641 aaaatccgtt cgcactgcct tcataagttc cgtctgcaag atcaaacgca ccgtctaaaa
     5701 cagcagccgc ttccgtattt tcaacttccg tctcttctac cgactccata ccggcacttt
     5761 cgataatagt ttccgtctct gtcagttcat cttctgactc tgaaccataa accgatgctg
     5821 tataatcact cagggaaacc actgcaccaa ttcccaccac cgctgccaga atgacgggta
     5881 caattcctga aatatttttc atacttgtct ccataccaaa tcattcgttt atactttttt
     5941 ttcaatgatc ttcgtatcca tttccgactc aaaactgtct gcgattccct ctgtgacata
     6001 gatttccctg tcatccgtca tcagaatcat gtcaaattca tcactgtgat ttctccaata
     6061 ttccgttgcg gcttctttcc ccataataaa aacggatgta gaaagtccgt ccgcaagcgt
     6121 tccatctgct gtgacaatgg aaacggaaat taacccgttc tccaccggat aaccggtttt
     6181 gggatctatg atatgatgat atgtcctgcc gtcctgctca aaataacgtt cataaccgcc
     6241 ggaagtgatc accgccttat cctgtatgga aagcacccta agatactgat ctgtatcctg
     6301 tgggtcctgc actgccacgc gccagctgct tccatccttc tttgttccaa gtgcctgcac
     6361 atttccacca agattgacca gtccgctctt gatcccgcag gcacgaaaaa tgtccatgat
     6421 acgtgcagaa gtataacctt tcgcgattcc tccaaagtcg atctgcattc cgtccttttt
     6481 aaaagcgatc tgcgatgtct ctttatcata agaaatatcc gatgcatctg tcagcgtgag
     6541 cagatcctta agttcgtctg cgcccggcac cctgaaattg tcatctgtaa atccccatgc
     6601 tttcataacc ggataaatcg caatatcaaa tgcaccatct gtagcttcat acagatccag
     6661 tgagcgttcc accagatatg ctgtctcctc cgagagtatt ccatctccgc tctgattgat
     6721 tttatatatc tcactgtcct catttcccgt agacaacaat tgatccagcc ggctgatctc
     6781 atctgccgcc tgatccacgg cctctgtggc tcctttgcca taagcagtta ccgtcatata
     6841 tgtgtccatt gcaaagagat ctctgctcgc ctcggtatct cccccatcgg taccacagcc
     6901 acctgccaca accatgactg ctgcaaaaat cagaaatata atttttcttt ttactttacc
     6961 ttcgctcatt ttccatctaa ctttagttag tattttctaa ccaatttagt ttacaatgca
     7021 ccagacgcaa atatcaatct gcacttttga gactttttct cattttgatc tccatttccc
     7081 atgttaccgc aaaaaaatcc cctcacatac agacaacaac ctgcatataa gaggattcct
     7141 caattatatt atatttcatt caatttaatt atatttcaat gcctttttga gagctgctga
     7201 aatcgccgtt cccacaacaa agcagacaat tgcctcaacc agtccgttga cacctacaaa
     7261 tgctaaaatg aacagcaatg cattttttgc accaagagct gatacaaatg actggatgta
     7321 ttccgtattg taaaatccaa tcactaacat tcccataaaa aatgtggtgt tcagcagcgg
     7381 acagcaaagg ttgctaatcg taacagatgc acctgacggc agctttgttt tacgaagtcc
     7441 tttatagatc agacctgtca gccatcccat taaaatacgg gtaggtacgc atactaaaaa
     7501 tgttaaaaat ccgttgattc caagcagtgc agcaccaaat gggctcatgc cgaagcactg
     7561 gatgaaactt gtaacaccga acacgccgcc taagattgcg cctgccgccg gtcctaacgt
     7621 aacagctcct accgctaccg gaacgacgat cagcgtgatc tcaagaccag ctgttctgat
     7681 atatccgatc ggggtaaaag ccatgatgag aatgatagca actaaaagtg ccatctccac
     7741 aagatacttt gtggaaaact ttttctgagt catagtctct tcctcttttc ttgtaatatg
     7801 taattttaca acgttattaa gtataacact tgcatgctca ttccgcaatc ccgcatccat
     7861 atttacttcg taatgtcatg tttttatttt catccaattt ttaccatatt ccatccaatt
     7921 aactatattt caatgctttc ttcaaagccg cggaaattgc ggttccgacg ataaaacata
     7981 ccaccgcctc aaccagtccg ttgattccga caaatgctat cacaaacaaa aatggattgc
     8041 tgacaccaag cgtctgaaca aacgactgga tgtactcggt ctggtaaaac ccaaatacca
     8101 gcatgctcat aaaaaacgtg gtatttaaaa gcggacagca cagattcgcg attgtgattg
     8161 atacattcga tggtattttt gttttgcgga ttccctgata aatcagtcct gtcagccagc
     8221 ccgtcaggat acgggtcggt acatacagca aaaatgccag aaacggattg atgctaagaa
     8281 gcatcgcacc aaatgcattc agtccgaagc agcgcaaaaa actggcaagt ccaaatacac
     8341 ctcctaaaat tgcaccagcc gcaggcccta aagtaacagc tcctaccgcc accggaacaa
     8401 cgatcagtgt aatctcaata cctgccgtct taatgtatcc gagtggggta aaagccatga
     8461 taagaatgat ggcaactaaa agtgccattt ccacaagaaa ctttgtggag aactttttct
     8521 tgttcatagt cccttcctct tttctcgttt ttatgtaatt ttatacgaaa cacaggacga
     8581 gccatttgta gatcagtatg aatttccggc atcctgtatc tctgcaacgt tactaagtat
     8641 aacatctggc agaattttcc gcaatcttag attgcgttaa tcctaaaatc ctaaaattgt
     8701 gccattctca gaattgcact accacttttt tatattttta ttgtttcctt aattatcaat
     8761 aaatgccatt gactttctgc tttttgcgtg caaagctaac catatattta taagaaaaga
     8821 gtttttacca tgatacagaa aaaaaatgta cttaacaccg ttccgattat ctgccttggt
     8881 gccctgcttt tgggggcggc atacgggcag cttcacacgc caatgacgcc gccaccgatt
     8941 acagctctcg cctcagatat tctgccgacg acaggcaatg tccgagcact tgttgttgtg
     9001 gtcgattttg cggatgcgaa atatgataca gacagacgcc tgtccgatga agaaatttcc
     9061 tcctatctgt ttggcacaga caatactgaa ttttatccct gtgagagcct gactagttat
     9121 tttgaccgtg cttcatacgg atcactgcat atgaccggaa atgtatttca ttacacagcg
     9181 aaaggtacga tcgcatccta cgaaaaaacg aacgatggat acgaaacgct ggtgcgtgag
     9241 gttctttccg gtttaaatga tacgatcgac tataccgatt atgattctga cggcgatggc
     9301 tatatcgacg ctctctgcct ttctgttcca agcagaggca atgctgattt ctggtatggc
     9361 tgtacggcat cctggtgggc ttccaccctg ccggatttag atggcgaaaa attaaggaag
     9421 ctgtctgatc ataccgcgca ctgatgcttc cagttatttt tcagaataca tgatccttga
     9481 ctatatcacc ccgaatggta attatgacgg tctgttttct tccggcggac ttcgtattta
     9541 tcacgtcgat gccacccttg caaacgacga atacggtacc ccctatctga ctgctgataa
     9601 ctacagtcct gtctacgatt ccaccaataa cggcaggcgg atcttagact ggtcaataac
     9661 ggaaatggct tttaccggga cggtgacgtg atcggaggca ctgccacagg ctttggctgg
     9721 tatgacaaca acggacagtt gaccattgat accgggtata cgatcacggt cgactccgta
     9781 tctgaggatc agaaaaactg taccataacg attttgacaa acaactaagt atattttccc
     9841 tcaactcctg accaagagcc tcaaatttcc tccaactcca aacaagaagc ctcaaatttt
     9901 ctccagctcc cagcaaaaag cccgtccttc ctgtcagctt cctcacagaa gccgcacacg
     9961 aaagacgggc tttctatctt acaggttatt cacctatgta ttatttgcct aactcagctt
    10021 ttaatgctgt tgttaaagca ggaacgatct tattcagatc accaaccaga ccgtaatcag
    10081 ctacgtcgaa gattggagca tcttcatctt tgttgattgc gatgatcagg tcagaatctt
    10141 ccataccagc tacgtgctgg attgctccgg aaataccgat tgcaaagtag atctgaggac
    10201 gaacagtttt accagtctga cctacctgta aatcaactgg taaccagcca ttctctacaa
    10261 ctgcacggga gcagcttaca gtaccgccaa gtacctctgc aagatcttcc aaaagtttga
    10321 agttctcttt ggaaccaact ccacgaccac cggaaacaag gatctttgct tccataatgt
    10381 ttgctgtgct cttaacagct tttacgatgt ttaagatctc aacatatctg ttgtttggtg
    10441 taaatcccgg gttgtactct acaacgtttg cttttgcacc gctgatcgga gcgatcttct
    10501 gcataacacc tggacgtaca gttgccatct gaggacggtt gtccgggcag gcaattgttg
    10561 cgatggtgtt accaccaaat gcaggacgtg tcattaataa ctggttgtgt ttctgctctg
    10621 attctttacc aggtgcagca accagtggga aatcaccgat ctcaagagat gtacagtctg
    10681 ctgtcagacc tgtttttact cttgcagaaa cagtaggtcc taagtcacgg ccgatagcag
    10741 ttgcaccaac taacatgatt tcaggtttga actcgttaat tacagatgct aatgcatgag
    10801 catacggctc tgttctgtag tcttttaatt caggatcatc tactacgata actttgtcag
    10861 caccatactc agctaactga tctgccaatc cttttacacc agaaccaatt aatacagcag
    10921 ttacgtctgt acctaaatct tttgctaagt ctttgccttt tccaagtaac tcaaatgcaa
    10981 cgccatctaa tacgttatct acctgctgtg caaagacaaa tactccttta tattcttcta
    11041 atgccatgtt attcaccact tttccttttt ttattagata atgtgtttct ctttgaattt
    11101 accgatcaaa tatgctacgg attctgccgg atcaaggttt actttctcac cagcaccctt
    11161 tgcaacttta tcagatgctt ttgcaatctt agtaggagat ccctttaaac caagatcaga
    11221 atcgtcaaca tcctttaagt ctgctctgcc ccaaacggtt acttctttgt caaatgcatc
    11281 gaagattccg cccggtgtca tgtaacgcgg ctcatttaat tcagaaagag cagttaccag
    11341 acaaggcatt tttgctttta actcatgata tctgtcttcg tactgacgtt ttacaacaac
    11401 agaatcaccc tctactttga tgtctgctgc gtaagagata accggaagtc caagatgctc
    11461 agcgatctga ggaccaacct gtgcagtatc accatcgata gcctgacgtc ctgtgatgat
    11521 caggtcatag tctaagttac gaagtgcacc agcgattgtg gtagatgttg cccatgtatc
    11581 agctccacct aatacgcggt ctgttacaag aactgcttca tcagcaccca ttgctaatgc
    11641 ttcacgaaga actgcatcag cctttggaag tcccatggta agaactgtaa cttttgctcc
    11701 tgtctcatct ttgattctaa gtgctgcttc aagaccagct ttatcatctg ggttcatgat
    11761 agcaagcatt gctgctctgt caagcgttcc atccgggttg aacttaacgc cgccctttgt
    11821 atcaggaacc tgtttaatac atactacgat attcatgtat ttttcactcc ttatgtttta
    11881 tatgtttaaa ttttacgcgg attgattcga aattacttta acagtgcacc ggagattacc
    11941 atacgctgga cttcgcttgt accctcgtag atctcagtga tcttagcatc acgcatcata
    12001 cgctctacat cgtactctct gatatatccg tatccaccga ataactgaac aacctcagtt
    12061 gtaacagcca ttgcagtctc tgctgcgaat aattttgctt ttgcagcttc tacagaatat
    12121 actttctgag tagcttttgc cattgctgct ttgtaaacta aaagctgtgc agcttcgatt
    12181 cttgcagcca tatcagcaag tttgaactgt gtattctgct gctgtgcgat tgaacgtcca
    12241 aactgttttc tctcttttgt ataagcgata gctctgtcta atgcgccctc agcgatacca
    12301 agtgcctgag cagcaatacc gatacgtcca ccatcaagtg tgtgcattgc gatcgggaaa
    12361 ccttttcctt ccggtcctaa cagattctct ttcgggattc tgcagtcttc gaagatcagc
    12421 tcataagtag atgatccacg gatacccatc ttcttctctt ttgttccgaa tgagaagcct
    12481 ggagctccct tatcaacgat gaatgcagag aagtttttct tctttctgcc tctcttatcc
    12541 tctgtgatgc ttgtgatagc gattacaata taaacatctg caactttacc attggtaatg
    12601 aagcattttg atccatttaa tacccactcg tcaccatcta aaacagcttt tgtctgtgca
    12661 ccctgtgcat cagtaccagc ccccggctca gttaatgcga atgcacctaa cttctcgcct
    12721 gttgcaagtg gttttacata tttctgtttc tgctcttctg taccatatgt catgatcgga
    12781 tcgatgcaga gagatgtatg tgcagataca acaacacctg tggttgcgca aactttagat
    12841 aactcttcta cgcacataac gtatgtaaga ggatcacaac cctgtccacc atattctttc
    12901 ggaaccggga ttcccatgaa tccgtatttc tgcattttct taaccgtttc tgccgggaaa
    12961 gcttctgtct catctgtttc ctgtgcaagc ggttttactt ctgtttcagc aaattccttg
    13021 aataaggaac gcgccatttc atgtttcttg tctaaagtga aatccatgat ctaattttcc
    13081 tccataaata tttattttac tgagcatcga ccggagtctt tgtacgatca gcattgtata
    13141 catagaatcc cttgccgctc tttgctccaa ggttaccacc acgaaccatc ttacggatca
    13201 gtgggcatgc acgatatttg ctgtcgcctg tctctttgta aagtacatcc atgatagcaa
    13261 ggcagatatc aagaccgatg aaatcaccta actctaacgg tcccattggg tggttagcac
    13321 caagtttcat agctgcatcg ataccagcga tatcggaaac accttccatt ttgatgaatg
    13381 cagcttcgtt gatcattggg attaagatac ggtttacaac gaaaccagca gcctcattaa
    13441 cctgtaccgg agtttttccg atctcttcag aaattttctt aatagctgca acagtttcat
    13501 ccggagtatt cacaccagcg ataacctcga tcagtttcat acggtctgcc gggttgaaga
    13561 aatgcatacc aaccattgga cggtttaatc cgtttccgat ctctgtgata gaaagactgg
    13621 atgtgttaga agcgaagata caatctggtt ttgcgatctc gtctaattct ttgaaagtag
    13681 ttttctttac ttccatgttc tcgaaagctg cctctacgat cagatcacag tctttgcaaa
    13741 ggtcttcttt taaacctgga gtgatttttg caaggatgcc atcaacagct tcctgtgtca
    13801 tttttccttt ttctactaat cttgcataac cttttttgat tttctctttt ccgccttcag
    13861 cccactcctg cttgatatcg caaagtgcta cttcatatcc ttctacctga gcaaatgctt
    13921 ttgcaatgcc ctgtcccata gttcctgcac caataacgcc aaccttcatt tcggttacct
    13981 cctgaaaata attatgttaa ctgtatgttt gaaaaatgca atccccggga agtcattccc
    14041 cgggaattac tatcaaaaac tattatctct caacgattgg agagaatccc ataccaccgc
    14101 cgatgcaaag tgtagcaaga cctctcttag cgtctctctt ctgcatctca tgcagtaatg
    14161 taacaaggat acggcatccg gaagcaccta ccgggtgtcc taatgcgatt gcgccaccgt
    14221 ttacgtttac ttttgacata tcgaatttca gatctcttgc tactgcgata gactgagctg
    14281 cgaatgcttc gtttgcttcg attaagtcca tatcatcaat agataaacca gtttttgcta
    14341 atacttttct tgtagaagca acaggtccaa cacccatgat ttcaggctca actccgccaa
    14401 gagcacctgc tacccatgta gccattggtg taacaccaag ttcttttgct ttctcttcgc
    14461 tcataacaac gattgctgct gcaccatcgt tgataccgga agcgttacct gctgtaacaa
    14521 gtccgccctc tttaccagag cagcatttta attttgctaa agactcagca gttgtaccgg
    14581 cacgtggtcc ctcatctttc acgaaatcaa cgatctcttt tttcacttta acaggaaccg
    14641 gaacgatctc atcatcaaat ttgccttcag cgattgcttt ttcacatttc tgctggctgt
    14701 ttgctgagaa ctcgtcaagt tcttctcttg taatgccata tttatcacat acgttctctg
    14761 cagtgatcat catatgatag tggttgaatg catctgttaa tgcatcattt accattgtat
    14821 cgatgatcgt tgcattgttc atacgatatc caaaacgagc ttttgtcata gcatatggtg
    14881 ccatagacat gttttccata ccacctgcaa caacgatatc agcttcacct gccatgatca
    14941 tggtagctgc atcattgaca cattttaaac cagaaccaca aacaacgttg attgtgattg
    15001 ccggaacttc gattggcagt cctgctttga ttgctgcctg acgtgcaacg ttctgtccct
    15061 gagctgcctg gattacacaa cccattttta cctcgtcaac catctccggt ttaacgtttg
    15121 ctcttcttaa agcctctttg ataacgattg cacctaagtc tgctgctgga gtattgctta
    15181 atgctccacc cattttaccg attgcggtac ggcaggcacc tgctaaaact actttctttg
    15241 ccattttgaa ttctcctttc aatttaacac aaagctctgc ttttgcagag aatttgtttc
    15301 tttctcttta aagttgccga aaaatgctgt taatttttta acaatctttt ttaaaaaaat
    15361 aaattcaaac tttcggttga aatttatctt tttttctttc attttaaaa
//
