GCA_025544275.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaCFHMEBGC_1 (original name was: gnl|Prokka|CFHMEBGC_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	ranthipeptide	163,952	185,559
Region 1.2	RRE-containing	314,015	334,278
Region 1.3	HR-T2PKS,NRPS	566,630	654,523	leucomycin	Polyketide	3%

gnlProkkaCFHMEBGC_13 (original name was: gnl|Prokka|CFHMEBGC_13)

Region	Type	From	To	Most similar known cluster		Similarity
Region 13.1	cyclic-lactone-autoinducer	1	15,828

gnlProkkaCFHMEBGC_35 (original name was: gnl|Prokka|CFHMEBGC_35)

Region	Type	From	To	Most similar known cluster		Similarity
Region 35.1	RRE-containing	1	9,093

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	ranthipeptide	163,952	185,559
Region 1.2	RRE-containing	314,015	334,278
Region 1.3	HR-T2PKS,NRPS	566,630	654,523	leucomycin	Polyketide	3%
Region 13.1	cyclic-lactone-autoinducer	1	15,828
Region 35.1	RRE-containing	1	9,093

No secondary metabolite regions were found in these records:: gnlProkkaCFHMEBGC_2 (original name was: gnl|Prokka|CFHMEBGC_2); gnlProkkaCFHMEBGC_3 (original name was: gnl|Prokka|CFHMEBGC_3); gnlProkkaCFHMEBGC_4 (original name was: gnl|Prokka|CFHMEBGC_4); gnlProkkaCFHMEBGC_5 (original name was: gnl|Prokka|CFHMEBGC_5); gnlProkkaCFHMEBGC_6 (original name was: gnl|Prokka|CFHMEBGC_6); gnlProkkaCFHMEBGC_7 (original name was: gnl|Prokka|CFHMEBGC_7); gnlProkkaCFHMEBGC_8 (original name was: gnl|Prokka|CFHMEBGC_8); gnlProkkaCFHMEBGC_9 (original name was: gnl|Prokka|CFHMEBGC_9); gnlProkkaCFHMEBGC_10 (original name was: gnl|Prokka|CFHMEBGC_10); gnlProkkaCFHMEBGC_11 (original name was: gnl|Prokka|CFHMEBGC_11); gnlProkkaCFHMEBGC_12 (original name was: gnl|Prokka|CFHMEBGC_12); gnlProkkaCFHMEBGC_14 (original name was: gnl|Prokka|CFHMEBGC_14); gnlProkkaCFHMEBGC_15 (original name was: gnl|Prokka|CFHMEBGC_15); gnlProkkaCFHMEBGC_16 (original name was: gnl|Prokka|CFHMEBGC_16); gnlProkkaCFHMEBGC_17 (original name was: gnl|Prokka|CFHMEBGC_17); gnlProkkaCFHMEBGC_18 (original name was: gnl|Prokka|CFHMEBGC_18); gnlProkkaCFHMEBGC_19 (original name was: gnl|Prokka|CFHMEBGC_19); gnlProkkaCFHMEBGC_20 (original name was: gnl|Prokka|CFHMEBGC_20); gnlProkkaCFHMEBGC_21 (original name was: gnl|Prokka|CFHMEBGC_21); gnlProkkaCFHMEBGC_22 (original name was: gnl|Prokka|CFHMEBGC_22); gnlProkkaCFHMEBGC_23 (original name was: gnl|Prokka|CFHMEBGC_23); gnlProkkaCFHMEBGC_24 (original name was: gnl|Prokka|CFHMEBGC_24); gnlProkkaCFHMEBGC_25 (original name was: gnl|Prokka|CFHMEBGC_25); gnlProkkaCFHMEBGC_26 (original name was: gnl|Prokka|CFHMEBGC_26); gnlProkkaCFHMEBGC_27 (original name was: gnl|Prokka|CFHMEBGC_27); gnlProkkaCFHMEBGC_28 (original name was: gnl|Prokka|CFHMEBGC_28); gnlProkkaCFHMEBGC_29 (original name was: gnl|Prokka|CFHMEBGC_29); gnlProkkaCFHMEBGC_30 (original name was: gnl|Prokka|CFHMEBGC_30); gnlProkkaCFHMEBGC_31 (original name was: gnl|Prokka|CFHMEBGC_31); gnlProkkaCFHMEBGC_32 (original name was: gnl|Prokka|CFHMEBGC_32); gnlProkkaCFHMEBGC_33 (original name was: gnl|Prokka|CFHMEBGC_33); gnlProkkaCFHMEBGC_34 (original name was: gnl|Prokka|CFHMEBGC_34); gnlProkkaCFHMEBGC_36 (original name was: gnl|Prokka|CFHMEBGC_36); gnlProkkaCFHMEBGC_37 (original name was: gnl|Prokka|CFHMEBGC_37); gnlProkkaCFHMEBGC_38 (original name was: gnl|Prokka|CFHMEBGC_38); gnlProkkaCFHMEBGC_39 (original name was: gnl|Prokka|CFHMEBGC_39); gnlProkkaCFHMEBGC_40 (original name was: gnl|Prokka|CFHMEBGC_40); gnlProkkaCFHMEBGC_41 (original name was: gnl|Prokka|CFHMEBGC_41); gnlProkkaCFHMEBGC_42 (original name was: gnl|Prokka|CFHMEBGC_42); gnlProkkaCFHMEBGC_43 (original name was: gnl|Prokka|CFHMEBGC_43); gnlProkkaCFHMEBGC_44 (original name was: gnl|Prokka|CFHMEBGC_44); gnlProkkaCFHMEBGC_45 (original name was: gnl|Prokka|CFHMEBGC_45); gnlProkkaCFHMEBGC_46 (original name was: gnl|Prokka|CFHMEBGC_46); gnlProkkaCFHMEBGC_47 (original name was: gnl|Prokka|CFHMEBGC_47); gnlProkkaCFHMEBGC_48 (original name was: gnl|Prokka|CFHMEBGC_48); gnlProkkaCFHMEBGC_49 (original name was: gnl|Prokka|CFHMEBGC_49)

Compact view

gnlProkkaCFHMEBGC_1 - Region 1 - ranthipeptide

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Location: 163,952 - 185,559 nt. (total: 21,608 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaCFHMEBGC_1 - Region 2 - RRE-containing

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Location: 314,015 - 334,278 nt. (total: 20,264 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaCFHMEBGC_1 - Region 3 - HR-T2PKS,NRPS

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Location: 566,630 - 654,523 nt. (total: 87,894 nt) Show pHMM detection rules used

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 3, location 566629 - 654523:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 607191 - 654523:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_590

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASFLGGVYK
Nearest Stachelhaus code(s):: Ile DALFMGGVYK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1479..1869): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMKNLGTVSK
Nearest Stachelhaus code(s):: Asp DMKDLGMVDK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

gnlProkkaCFHMEBGC_13 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 15,828 nt. (total: 15,828 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

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resistance

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KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaCFHMEBGC_35 - Region 1 - RRE-containing

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Location: 1 - 9,093 nt. (total: 9,093 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.