LOCUS       c00040_gnlPro..        14066 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CFHMEBGC_40.
ACCESSION   c00040_gnlPro..
VERSION     c00040_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 16:18:05
            Original ID  :: gnl|Prokka|CFHMEBGC_40
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14066
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14066
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1166:4066]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1167..4066
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14066
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14066
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(303..920)
                     /locus_tag="ctg40_1"
                     /transl_table=11
                     /translation="MAEETNSNCLFNNYDYKYLKYKIGVGRSLKQRAYEEIFSPVFPNE
                     LVLHNYAFCSELKCENCLNYVSCRSDYLKEIESQMLKIIEWRNRDEICQAISVFQSIID
                     SNYCIENEKELEEIKREFREKQIKINKNINKIFPKIKRWTNITSVIATPFAISSALANN
                     TKLAITGSVFAGTSTIVNELMKYYENKNKWVGFINNSHNNTL"
     CDS             1167..2438
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_2"
                     /sec_met_domain="HGD-D (E-value: 3.7e-48, bitscore: 154.7,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLIELFGNHIYKTALTNPLSARKKLCFAFSTAGLMCKYFPTKK
                     LLPSRQFMQWAAADSAITPLKTGKNSAIVSLYLPCEILHSMGISTLFPEALACYLAAAR
                     SEQVFIDTAEQNFVSQTMCSYHKAFIGMVETGVLPKPDFIINTTLACDANHLSFRRAAE
                     HYNVPQYMIDVPYNYSSGAVDYVAKQIKDMVTFIEKQGYTFDEAKLIETVEKSKQTLKN
                     FNDILALRANRSLSDEMTSQMLSVFATHVMLGTDNALKYSTDLKNELAAVPEGKKGVRL
                     LWVHTLPYWQDALRDLINFTDRCEIVACDMVMDAMYCDLEETDPYRFMADRLVRNTVNG
                     NGTNRINATLELAKKLNANGIVWYCHWGCKQTAGLSNIAKSTFEANGFPTLILDGDGCN
                     WNNVNDGQTVTRTEAFLELLENRK"
     CDS             2435..4066
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_3"
                     /sec_met_domain="HGD-D (E-value: 1.2e-17, bitscore: 54.5,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 5.5e-60, bitscore:
                     192.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGYNCKYTPVEILACFDDYRLINNEAEHFDYSSQAMHSNVCSHI
                     KAICEEIHRGDYDKLVFMNCCDSTRRLFDVAESKTKYKTILDLPIDNGACAVKRLKNDL
                     LFLIKDLESVTGKAFDTKEFLHNFSDKPIAFPNSKFILVLGANANGSLMNVIREAFQIP
                     VINMTCSNNRCVSNENMSENDSLDELMEKYARALMAQTPCMRMSDTTSRKQLLNNENLA
                     GIVYHTIKFCDYYCFEYTKLADSKTPILKIETDYTTQQLGQLSTRLEAFCETLNTENNS
                     KIKMNKNGKYYAGIDSGSTSTELVIFDENKNIVKAVMVRTGANAQAGAQKALDEAQISL
                     DEIKTVTATGYGRKNIDFANDDVTEITCHARGARFLYPEARYIIDIGGQDSKFITLDEN
                     GNVASFVMNDKCAAGTGRFLENMAKALEISMEQMANDGLKYSEDISISNMCTVFAESEV
                     ISLISENKKIADIIHGLNKSVAIKTKALASKAHGADGVMMTGGVANNKGVVTELEKQLN
                     TKIFISDKPEFCGAIGAGLFAVDSDR"
     CDS             4193..4498
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lipase_GDSL_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_4"
                     /sec_met_domain="Lipase_GDSL_2 (E-value: 1.6e-18, bitscore:
                     57.6, seeds: 1564, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VLFGDSITEIFNSYELFYAFSQTTGQAVYNRGISGDTSDRLLERL
                     ECNALNINPKNLVILIGTNDIGIGVPTEYTLKNVKEILQRTQKLCPNTAVKSSIRA"
     CDS             complement(4597..5424)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hydrolase_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_5"
                     /sec_met_domain="Hydrolase_4 (E-value: 3.5e-15, bitscore:
                     45.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFKKPVLSDGITESTFECKRDGLTIRGTVYRPKGEHLPIAIVCH
                     GFMAWQDSVKHYAAFLAEMGYAAFTFDFCGGSAMCGKSDGKTTEMSVLTETKDLEAVIE
                     YVRNLSYTDSEKILLMGCSQGGFVSALVAAKNNFPIEKLVLFYPALCIPDDARAGKMMI
                     ARFDPQNVPDTFRCGLMKLGRCYAMDVMQMDAFAEIKNYAGRVCIVHGTKDKIVDVSYA
                     NRAAEAYKSTMPIGMQESKRVQLHFIDGGGHMFSKKHDVIAMKLLKEFAAKHE"
     CDS             5958..6929
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hydrolase_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_6"
                     /sec_met_domain="Hydrolase_4 (E-value: 5.9e-15, bitscore:
                     45.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRKNVGIAFGALCGLAALTATAAEIFYDISINTKSPIHMSKLNN
                     LVQKATNTAGNEEEASAKYSGMTGTPEIKEWYATHGEDVYILSDSLRLHGKRFKNTGTK
                     YVLVCHGYTSKAKHMAGFVHKFYTLGYNVLAVDARAHGDSEGTKIGMGWPERVDIIKWI
                     NRILSWEPNARIVLHGVSMGAATVLMASGEDLPGNVKAVIADCGYTSEWDEFQREADAL
                     HIPWFPVLNATSVLSKIRDGYDFKQASALAQVKKSRIPTLFIHGLSDELVPYSMLGELY
                     AAAACEKEELTVEGAGHALSSSVAPTLYWRTVEDFIAKYLDR"
     CDS             7187..7651
                     /locus_tag="ctg40_7"
                     /transl_table=11
                     /translation="VYENKHRPITDDERRMILETIPKHYAGTIVLTMLCCGLRPIEIRR
                     MKWDWIDFENAILTVGKSKTKAGTGRKIPIPPVLLDALKEHKAKELNNEYVFVKYEKHT
                     RMDDNRKKCYQCFLFVIKYDLTILQQRSNTSEKKNSVYLIFSERNMFIWL"
     CDS             7590..7934
                     /locus_tag="ctg40_8"
                     /transl_table=11
                     /translation="VKKRILFILFLVSVICLSGCNSNTSLIEGNSDPEPIKSEDQEIQN
                     FLDVEVDSSYDNIIVKMEKDSYSVDSDQIICTVQDNNVGKAFYFYEIPFIEKKLMIIGL
                     DFIIIQTALT"
     CDS             complement(8313..8849)
                     /locus_tag="ctg40_9"
                     /transl_table=11
                     /translation="MKFKKYATKTLMIVIGSIISAYGITLAIGAGFGGATLAILWQGLT
                     NVTGMSIGTILYQIIYSFFVDVFTKIQHYTDIKALNFVIMLLGIAIFSFGTGIYSAADF
                     GRGSYEAVTFSLAEKNGWKIKIVRMALDIIMVIIGVLLGGKFGICTIATVLLSGPIIQA
                     TVSTVKKSKILKNIS"
     CDS             complement(8895..9077)
                     /locus_tag="ctg40_10"
                     /transl_table=11
                     /translation="MTETFDRHRSNQNRNTNSNEQNSEQIQKIIFITVDFIKARVYNQK
                     NKAVSADEDYKFCCF"
     CDS             complement(9070..9189)
                     /locus_tag="ctg40_11"
                     /transl_table=11
                     /translation="MDEQEKEIEEILRTFDKAPSPSSENSVQSHFSAIGGIYD"
     CDS             complement(9293..13255)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fn3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_12"
                     /sec_met_domain="fn3 (E-value: 6.3e-12, bitscore: 35.7,
                     seeds: 98, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKITAIFLALCMAISVLPMTIQAASKPDIKVGDYVKMGAYNNA
                     SILWRCVSIDNNGPLMLADKIVDTLAYDAKTNDNSNSKSHSRSYKRDDYGSNYWKDSNM
                     RSWLNSTAAEGKVDWLCGNPPKDGYVSGVGAYNEKAGFLNAFSKSEIAAMKTVTQRSLV
                     SHPEYNKGIVDGDANSDLLYYTDISEAVANYDSSYFETTTEKVFLLDVKQANAVWKNLK
                     GYYVAYNNDGMAWPYWLRTPVTDCNHDMRYISSSGQVGRYAPWYSDLGVRPAFYLDSEY
                     FVTTSGSGSQSSPYIGSAPNKQEDDYTISEPAEDANPDWNVSTEQSIQLTLGPWYSNDG
                     KYSNPTIPVYTIQKTRSDTENMVVVVCGEGYTKSQQGKFINDVKRLWQDAMKYEPYRSY
                     ADRFNVYALCTASESTFDNGGSTFFDVIVDKYNSPVISNNLHGSQWKNHIFERCIGPEF
                     IEKIHDAHIKKKCDPNTIPSGSEYEPYYYVHDYIAQFAMVVNTKSDFGGAYNNREYGFH
                     YFISPSDSYRASKTFAHEFGHGLLGLGDEYSNGYLLDDKELKSLNLSSVEDPEKIKWRQ
                     LLGFRNTYTCRNAYGSKMLVSSYECIMRDTNYQFCEVCRLQGFKRMSQLVKDVDLYVAT
                     PEVKEYTGAYSKPSDFTNLETSSYYNYTYNRNDRLLSGNSKSRFNTNMNGKKIELRTVI
                     QNISDKNARQLKFKMWIKHSDGSVATDSSGNPLQTVQTFDIPVWNDKANFWPLGALDHI
                     KSDFNSGLKSCSLIYQIPSDAQLKSGDTVAFQVLDENGNVLADDNTETQRYTTVSIQYK
                     FEDGSEIPNTAGGTFTVPYGTKLDLTPAKTLYDYEFIKVDGLNKPIVSDGTVVTYYYKN
                     KNEKHTHNLTLVAAKAATCTTAGNSAYYTCDGCDKWFADATGSVEITDKTSVKIAPLNH
                     DWNAPAYTWNADNTVCTATRTCKRDAGHKETAIATVTSAQTKAPTCTAKGETTYTAAFT
                     EAWANTQTKTVDNIAALGHDWSTAWTGDSTGHWHKCTRCDATTTKAAHDYGSDNVCDTC
                     GYNKTVPHTHNLTLVAAKAATCTEGGKEAYYKCEGCGKFYEDVLGTKEITDLASWGNIA
                     KIAHTTKQTVTKATPTANGKIVNYCSVCKKTLSTTVIPNASSIKLKATSLTYNGKVRTP
                     KVIVKDRTGKTLVKNTDYTVSYAKGRKYVGKYAVKITFKGKYSGTKTLYFTIKPKATSI
                     SSLTAGSKKFTVKWKKQATQITGYQVQVATNKKFKKNKKTVTIKKQKTTKTTVKKLKAK
                     KKYYVRVRTYKTVKINGKSIRIYSGWSKAKTVTTKK"
     CDS             13444..13800
                     /locus_tag="ctg40_13"
                     /transl_table=11
                     /translation="MRFLGLVASQGGLFHLPENTFLKKVLQKRLNTKIFISDKPEFCGA
                     IGAGLFAVDSDRLLERLECNALNINPKNLVILIGTNDIGIGLPPEYTLNNIKEILQRTQ
                     TLCSNTAVKSSIRA"
ORIGIN
        1 atattagtac tatatcacaa aactaattag aataaaagta taaaaattgg atattatcaa
       61 aagaggtttg ccccaaatgt tagggcaaac ctctttttag gttgtgtctc tatttttcac
      121 tgacaattgc atctctcaaa aatctctcag aattttattt ttgctcagca cagcaaattc
      181 gtatgagaaa ttgcgaacat tacatagaag agtatatgat tatgataggt acagcaattc
      241 aatttgctat acctatccga ctgcagaaaa catatatttt cttcctagca cctatttcat
      301 agtcacagag tattattgtg tgaattattt ataaaaccaa cccatttgtt tttattttca
      361 taatatttca tcaattcatt aacaatagtg gaagtgcccg caaacactga tcctgttata
      421 gcaagtttag tattatttgc taaagcagaa cttattgcaa atggagtagc tataactgat
      481 gttatgtttg tccatctttt aattttaggg aatattttat ttatattttt gttgatttta
      541 atttgctttt ctctaaattc tctttttatt tcttctaatt ctttttcatt ttcaatacaa
      601 tagtttgaat caattataga ttgaaataca gaaattgctt gacaaatttc atctctgttt
      661 ctccattcta ttattttaag catttggctt tctatttctt ttaaataatc acttcgacaa
      721 gatacatagt ttaaacaatt ttcacatttt aattcagaac aaaaagcata attatgtaat
      781 actaattcat ttggaaaaac aggagaaaag atttcctcat aagccctttg ttttaacgac
      841 ctaccaacac ctattttgta tttcaaatac ttataatcat aattattaaa taaacaattt
      901 gaatttgttt cctctgccat aattaagctt gtctgttgaa agctgatagt gattatacgg
      961 cagttttctt ttgcctgttt ttgtcaatgt gattttgttt ttgaaatcaa catccgacac
     1021 ctgctcacaa aggatttttc cgttgtcgca ataaattgtg ccgtcaagga aataaggctt
     1081 gttgtcaatg aagtgaaaac gctttgcttt ttatatatcg ctgtgctata atcaaaatta
     1141 aataacacaa ggaatactat aacccaatga acaatttgat agaattattt ggaaatcata
     1201 tatacaaaac cgcactaaca aatcctttgt cagcaagaaa aaagctgtgc tttgcattta
     1261 gcacggcagg tcttatgtgc aaatatttcc cgacaaaaaa gcttttgccg tcacgccaat
     1321 ttatgcagtg ggcggctgcc gattctgcaa ttacaccgct gaaaacgggc aaaaattctg
     1381 caatcgtaag cctgtactta ccgtgtgaaa ttctgcattc catgggcatc agcacactgt
     1441 ttcccgaggc tcttgcctgc tatttggctg cggcaaggtc ggagcaggtg ttcatcgaca
     1501 cggcggagca aaattttgtt tcgcaaacta tgtgctctta tcacaaggct ttcatcggaa
     1561 tggtggaaac aggcgttttg ccaaagcctg attttattat caacacaacc cttgcatgtg
     1621 acgcaaatca cttgtcgttc aggcgagcgg cggaacacta caatgtgcct caatatatga
     1681 ttgatgtgcc gtacaattat tcaagcggtg cggtggatta tgttgcaaag caaatcaaag
     1741 atatggtgac ctttattgaa aaacagggct atacttttga tgaggcaaag ctgattgaaa
     1801 cggttgaaaa atcaaagcag acgctaaaga atttcaatga tatattggca cttcgtgcaa
     1861 atcgttcgct gtcggacgaa atgacttctc aaatgctttc ggtttttgca acacatgtta
     1921 tgctcggcac ggacaacgca ttgaaataca gcaccgattt gaaaaacgag cttgccgccg
     1981 ttccagaggg caaaaagggc gtaaggcttc tttgggtgca caccttgcct tattggcagg
     2041 acgctttgcg tgatttgatt aactttaccg accgttgcga aattgtcgct tgcgatatgg
     2101 ttatggacgc tatgtactgt gaccttgaag aaaccgaccc gtacagattt atggcagacc
     2161 gacttgtcag aaacaccgtc aacggaaacg gcacgaacag aataaacgca acgcttgaac
     2221 ttgccaaaaa gctcaatgcg aacggcattg tttggtactg ccattggggt tgcaagcaaa
     2281 cggcagggct ttcaaatatt gcaaaatcga cctttgaggc aaacggtttt ccgacgctca
     2341 ttcttgacgg tgacggctgt aattggaaca atgtcaacga cggtcaaacc gtgacgagga
     2401 cagaagcatt tttagaactg ttggagaaca gaaaatgatt ggatataact gcaaatacac
     2461 accggtggag attttggcat gctttgacga ttatcgttta atcaacaacg aagcggagca
     2521 ttttgactat tcttcacagg ctatgcactc aaatgtttgc tcacacatca aggcgatttg
     2581 cgaggaaata catcggggcg actatgacaa gcttgttttt atgaactgct gtgacagcac
     2641 aagacgattg tttgatgtgg cagaaagcaa gactaaatac aaaaccattc ttgacctgcc
     2701 gattgataac ggtgcttgcg ccgtaaaacg attgaagaat gatttacttt ttctcattaa
     2761 agaccttgaa agcgtaacag gcaaagcgtt tgacacaaaa gaatttttgc acaatttcag
     2821 cgacaagccg attgcgtttc cgaacagtaa attcattttg gtgcttggtg caaatgcaaa
     2881 cggaagcctg atgaatgtaa tcagagaagc gtttcaaatt cctgtaatca atatgacttg
     2941 ctcaaacaat cgctgtgttt caaacgaaaa tatgagcgaa aacgacagtc ttgacgagct
     3001 gatggaaaaa tacgcaagag cgttgatggc gcaaacgcct tgcatgcgaa tgagcgacac
     3061 gacctcaaga aaacaactgc taaacaacga aaatttggca ggtattgtat accacacaat
     3121 caagttttgc gattattatt gctttgaata cacaaaactt gcagacagca agacaccgat
     3181 tttgaaaatt gaaacggact acaccacaca gcaattaggt cagctttcaa caaggctgga
     3241 ggctttttgc gaaaccttga acacggagaa taattcaaag ataaagatga acaaaaacgg
     3301 aaaatattac gcaggaattg acagcggttc aacctcaaca gagcttgtca tttttgacga
     3361 aaacaagaat attgtaaagg ctgttatggt cagaacaggt gcaaacgctc aggcaggggc
     3421 gcaaaaggca cttgacgagg cacaaatcag tcttgacgaa ataaaaaccg taaccgcaac
     3481 aggctatggc agaaaaaata ttgattttgc aaacgatgat gtaacggaaa tcacttgcca
     3541 cgcaagaggg gcgaggtttt tgtatcccga agcacgatat attattgaca tcggcggaca
     3601 ggattcaaag tttatcaccc ttgacgaaaa tggcaatgtt gcatcgtttg ttatgaacga
     3661 caaatgcgca gcaggcacgg gcagatttct tgaaaatatg gcaaaggctc ttgaaatcag
     3721 tatggagcaa atggcgaatg acggtttaaa atacagcgag gatatttcaa tttcaaatat
     3781 gtgcacggtg tttgccgaaa gcgaagtgat ttcgctgatt tccgaaaata aaaagatagc
     3841 cgatattatt cacggtttga acaaaagtgt tgcgataaag acgaaggctc ttgcaagcaa
     3901 ggcacacggt gcagacggtg taatgatgac gggcggtgtt gcaaacaaca agggcgttgt
     3961 aaccgaactt gaaaagcagt tgaacacaaa gatttttata tccgataagc cggaattttg
     4021 cggtgcaatc ggtgcgggat tgtttgccgt tgacagcgac agataaacct aatttcggag
     4081 agaagcaaat gaacaagaac tttcagaaaa aacggcttac gaacatgtaa agcaaacgaa
     4141 aaaagagaat tttagttttt tgaatgagaa gtacgcacag cagggacaaa cagtgctgtt
     4201 cggcgactca atcacggaaa tattcaacag ctacgagctg ttttatgcct tttcgcaaac
     4261 aacggggcag gcagtttaca accgtggaat cagcggtgac acaagcgaca gattgttgga
     4321 aaggctcgaa tgtaacgcct tgaacataaa cccgaaaaat cttgtgattt taatcggaac
     4381 gaatgacatc ggcataggag ttccgaccga gtacaccttg aaaaatgtaa aagaaatttt
     4441 gcaaagaacg cagaaactat gcccgaatac cgccgtaaaa agcagtattc gggcataaaa
     4501 ataggctgaa agtaaaactt ccagctttgt ggcagattat atcaacctgt caagtcttta
     4561 aaggtggaga tttgtccata tggtatcaga tgaaaattat tcgtgttttg cggcgaattc
     4621 ttttaataat ttcattgcaa tgacatcatg ctttttcgaa aacatatgtc ctccgccatc
     4681 tataaaatgc agttgcaccc gcttggactc ttgcattccg atcggcatcg tacttttata
     4741 tgcttctgcc gcacggttgg cataagaaac atctacgatt ttatcctttg taccatgcac
     4801 gatgcacacc ctgccggcgt agttcttaat ttctgcaaag gcatccattt gcatgacgtc
     4861 cattgcatag caacgcccca atttcatcag cccgcagcgg aaagtatcgg gaacattttg
     4921 cggatcaaat cttgctatca tcatttttcc ggctctggcg tcatccggga tacacaatgc
     4981 cggataaaac aggacaagtt tttctatcgg aaagttgttt tttgctgcca ccaaagcaga
     5041 cacaaaaccg ccctgactgc atcccatcaa taaaattttt tcagaatctg tataggaaag
     5101 atttctaaca tattcaatga ccgcttccag atctttggtt tctgtcagaa cagacatctc
     5161 tgtggttttt ccgtcacttt ttccacacat agcagaaccg ccacaaaaat caaatgtaaa
     5221 tgcagcatat cccatttcag ccaaaaaagc cgcataatgt ttcacactgt cttgccatgc
     5281 cataaatccg tgacatacga ttgcaatcgg aagatgttct ccttttggac ggtacactgt
     5341 tccacgaatc gtcaatccat ctcttttgca ttcaaaagtg ctttctgtaa ttccatctga
     5401 caaaacaggt ttcttaaaaa tcataatttt tctccaaatt cagtggcatt ttgtttttgt
     5461 tgcatcggct atatttttaa cactgatttt gtgtaaatgt tttagccgat agctattttg
     5521 cttgttataa tcattaagca cggaaaacac aaaagagcat tctttcatga tcgacatatt
     5581 gttctttggt ttactgttaa ctcacactgt catagtacaa taatgccatt actttgtcaa
     5641 gaaccggaac gatgttacgg gtttatttgc attataaacc cataataaga acatcaccca
     5701 tttacaaaat cacagatttt gaatgggtct tgataacctt gttactcgct ttgctcgtaa
     5761 taagtattct tcgaatcctt atctttttct tgcaaaatgt ggcagcggtt ttattgacat
     5821 ccgtccaaaa atgtgatttg atatacacag agcgctttgg tattgtaaag acagccgggg
     5881 cgcgcacaaa acagcttcag attgcaaaat gacattttga gacaatgtta tgcttttgac
     5941 gacaggagga gatttttatg aatagaaaga atgtaggtat agctttcggc gcgctttgtg
     6001 ggctggcagc tttaactgca acggcagcgg aaatattcta tgatatctca atcaacacga
     6061 aatcgcctat ccatatgagc aaactcaaca acttggttca aaaagccacg aatactgccg
     6121 gcaatgaaga ggaagcaagt gcaaaataca gcggtatgac aggcacaccg gaaattaaag
     6181 aatggtatgc tacacacgga gaggatgtgt atattctgtc tgattcgctg cgcctgcacg
     6241 gaaaacggtt caaaaatacc ggcacaaaat atgttctcgt atgccacggc tatacaagca
     6301 aggccaagca tatggccgga tttgttcata aattttacac gcttggttat aatgttttgg
     6361 cagtagatgc aagagcccac ggcgacagcg agggaacaaa aatcggtatg ggctggccgg
     6421 agcgtgtgga tattataaag tggataaacc ggatcctttc atgggagccg aacgcccgga
     6481 tcgttctgca cggtgtatcc atgggggcgg caacggtttt gatggcgtca ggtgaagatt
     6541 tacccggaaa tgtgaaggct gttattgcag attgcggcta cacgtcggaa tgggatgagt
     6601 tccaacggga ggcggatgcc ctgcatattc cgtggttccc cgtgctcaac gccacatcgg
     6661 tattgtcaaa gattcgtgac gggtatgatt ttaagcaggc cagcgccctt gcgcaggtga
     6721 aaaagagccg cataccaacg ctgtttattc acggcttgtc ggatgagctt gtgccgtaca
     6781 gtatgctggg cgaattgtat gcggctgcag cctgcgaaaa agaggaactt accgtagaag
     6841 gcgcaggcca tgcgctctcg tcttctgttg cgcccacgct gtattggcgt acagtcgagg
     6901 attttatcgc aaagtattta gataggtaag ctgaatttat ttgccattta tgcggaaatg
     6961 tgtaaatata aacgcccggg agaagcggtt cgttatggag gatgcgccgg cgtttggcgc
     7021 taggatcgtc gccgatttga caggtaaata ggactctatg cagcggcgca ccaaacggtg
     7081 cgtcgctttt gcatcctgtg tgctaatgct gtgttgcaaa agacggtcgg gtgtggtaca
     7141 cttgtattag agttctatgc atttttgcaa aaaggggagg gtgcctgtgt acgagaacaa
     7201 gcacagacca ataactgatg atgaacgccg aatgatactt gaaaccatac caaagcacta
     7261 tgccggaaca atagtgctta caatgttatg ctgcggactt cgaccgatag aaatccgaag
     7321 aatgaagtgg gattggatag attttgaaaa cgcaattcta acagtcggca aatccaaaac
     7381 gaaagcagga acaggacgaa agataccaat tccgcctgta cttttagatg cattaaagga
     7441 acataaagca aaagaactca acaatgaata tgtattcgta aagtacgaaa agcacacacg
     7501 catggatgac aacaggaaga agtgctacca atgtttttta ttcgtaatta aatatgattt
     7561 aactatttta cagcaaagga gtaataccag tgaaaaaaag aattctgttt atcttatttt
     7621 tagtgagcgt aatatgttta tctggttgta attcaaacac ttccctaata gagggaaatt
     7681 ctgatcctga accaataaaa tctgaagatc aagaaattca aaattttttg gatgtggaag
     7741 tggactcatc ctatgataat ataatagtaa aaatggaaaa ggattcatat tctgtagatt
     7801 cagatcagat tatttgtaca gttcaagata ataatgttgg caaagcattt tatttttatg
     7861 aaattccttt tatagaaaaa aaattgatga taattgggtt agactttatt ataattcaaa
     7921 ccgccttgac atagcccaat ggatgctatg tgctgaggag ggaaacacta ctgaaccgaa
     7981 ttcttcccga tatactgtta ggctcgctga tattaaacca aaagtaacac caggtgaata
     8041 tagattagtg gtatttacag caaaaaaaac actatatgca ccatttacat tagtaaaata
     8101 aaggagatac cctgctcata catttttatg atttcttttt cgtaatcact tatatgtcta
     8161 tattttcgtg gcataaaaat ttcccctatg gtagtttatt acattctacc atagggggtc
     8221 tgttttttct attgtccatt ttttgcggaa ttgttcaaat tgaattccat cctttttgta
     8281 tgtcttatca cttttaggct tgtatgagaa ttttaagaaa tgttttttaa aatctttgat
     8341 ttcttaacag tgcttacggt tgcctgaatt atcggaccgg agagcaaaac ggtggcaatt
     8401 gtgcaaattc cgaatttacc gccgagcaaa acgccgataa tcaccattat aatatcaaga
     8461 gccattcgta cgattttgat tttccacccg tttttttctg caagcgaaaa tgtgactgct
     8521 tcatatgagc ccctgccgaa atcagcggcg gagtaaatcc ccgttccaaa cgaaaatata
     8581 gcaatgccaa gcagcattat aacaaaatta agtgctttaa tatctgtata atgctgaatt
     8641 tttgtgaata catccacgaa aaaactgtaa atgatttggt aaagaattgt gccgattgac
     8701 atacctgtca cattcgtcag cccttgccac aatatcgcaa gtgttgcgcc gccgaaacct
     8761 gcgcctattg caagcgtaat tccgtatgcg gatattattg atccgataac gatcatcagc
     8821 gtttttgttg catatttttt aaatttcata ttatcacctg caaaaaaata agactgtaaa
     8881 ctctgctgtt gtgttcagaa acagcaaaat ttatagtctt catcagccga gacagcttta
     8941 tttttttgat tatacacccg agcttttata aagtcaacgg ttataaatat gattttctgt
     9001 atttgctcgg agttttgctc attactattc gtgttacgat tttgatttga gcgatgtcta
     9061 tcaaaagtct cagtcataaa tgcccccaat cgcactaaaa tgactttgaa cactattctc
     9121 tgacgaaggc gaaggtgctt tgtcaaatgt tctgagtatt tcttcaattt ctttttcttg
     9181 ttcgtccatt tgatttctcc ttgttcgatt tctttccgaa gaaatccttt tcgtgaggaa
     9241 aaggcggcag cggaagctcc gctaccgcca ttcttaaatg gttagctatc tgttatttct
     9301 ttgttgtaac agtcttagct tttgaccagc ctgaataaat ccttatggat ttgccgttaa
     9361 tcttaactgt cttataggtg cgaactctta cataatattt tttctttgcc ttaagctttt
     9421 taacggtagt ctttgtagtc ttctgcttct tgattgttac ggttttcttg ttcttcttga
     9481 atttcttatt ggttgcgact tgaacctgat agcctgttat ctgtgtagcc tgcttcttcc
     9541 actttactgt aaacttcttt gaacctgctg taagtgagga aatacttgtt gcctttggct
     9601 tgattgtgaa ataaagcgtc tttgttccgc tgtatttacc cttaaaggta atctttactg
     9661 cgtacttgcc aacatacttt ctgccttttg cataagacac agtatagtca gtattcttaa
     9721 caagtgtctt tcctgttctg tccttaacaa taaccttagg tgttctaacc tttccgttat
     9781 atgttaatga tgttgcttta agctttatgc ttgatgcatt tggaattact gttgttgaaa
     9841 gagttttctt acataccgaa cagtaattta ctatcttgcc gtttgctgtt ggggttgcct
     9901 ttgttacggt ttgctttgtg gtgtgggcaa tcttagcaat attgccccaa gatgcaaggt
     9961 cggttatttc ctttgtaccg agtacatctt catagaactt gccacaacct tcgcacttgt
    10021 agtatgcttc cttaccgccc tctgtgcagg tggcagcttt cgcagcaacc aaagtcagat
    10081 tgtgagtgtg cggtacagtt ttgttatatc cgcaggtgtc gcaaacattg tcagaaccgt
    10141 aatcgtgagc cgctttggtt gttgtagcat cgcagcgagt acatttatgc cagtgacctg
    10201 tgctgtcgcc ggtccaagcg gtactccaat cgtgaccgag agctgcgata ttgtcaacag
    10261 tcttggtctg tgtatttgcc caagcttcag taaaggctgc tgtataggtt gtttcgccct
    10321 ttgctgtgca ggtcggagcc tttgtctgtg cgcttgttac agtagcaatt gcagtttcct
    10381 tatgacctgc atcacgctta caggtgcgtg ttgctgtgca aacggtgttg tctgcattcc
    10441 aagtgtaagc aggtgcgttc caatcgtgat tgagaggtgc aatctttacg cttgttttat
    10501 cggtaatttc taccgatcct gttgcatctg cgaaccactt gtcacagcca tcgcaggtgt
    10561 agtatgcgga attgcccgca gtagtgcagg tggcagcttt cgcagcaacc aaagtcagat
    10621 tgtgagtgtg tttttcgttt ttatttttgt aataatatgt aacaaccgtt ccgtccgaaa
    10681 caataggctt attcaagccg tcaaccttta taaattcata atcataaagt gtttttgccg
    10741 gtgttaaatc aagctttgtg ccgtatggca cggtaaatgt tccgccggca gtgtttggaa
    10801 tttcagagcc gtcctcaaat ttatactgaa ttgaaacggt tgtgtagcgc tgtgtttccg
    10861 tattgtcgtc tgcaagcaca tttccgtttt catcgagcac ctgaaatgcc acggtatcgc
    10921 cgctcttaag ctgtgcatca gacggaattt gataaataag cgagcaactc tttaagcctg
    10981 aattaaagtc gcttttgatg tgatccaaag caccgagcgg ccagaaattt gccttatcat
    11041 tccaaacagg aatgtcaaag gtttgtactg tttgaagcgg attccccgat gaatcggtcg
    11101 caacgcttcc gtcggagtgc ttaatccaca ttttgaattt taattgtcgt gcatttttat
    11161 ctgaaatgtt ttgaataaca gttctaagct cgattttttt accgttcata ttagtattaa
    11221 atctgctttt gctgttgccg ctcaaaagtc ggtcattgcg attatatgtg taattataat
    11281 atgaacttgt ttcaaggttg gtaaaatcag acggctttga ataagcgccc gtatattcct
    11341 taacctcggg agttgcaaca taaaggtcta catccttaac aagctgagac attcgcttga
    11401 agccctgcaa acggcaaacc tcacagaatt gatagtttgt gtctctcatt atgcactcat
    11461 aacttgaaac aagcattttt gagccgtaag cattgcggca ggtatatgtg tttctaaaac
    11521 ctaaaagctg tcgccatttt atcttttccg ggtcttcaac cgaggaaaga ttgagtgatt
    11581 taagttcctt atcgtcaagc aaatatccgt tactgtattc atcaccgaga ccgagcaaac
    11641 cgtgtccaaa ctcgtgtgca aaagtttttg acgcacgata actgtctgat ggcgaaatga
    11701 aataatggaa gccgtattca cggttattat aagcaccgcc gaaatctgat tttgtgttta
    11761 caaccatagc gaactgagca atataatcgt gaacataata ataaggctca tattccgaac
    11821 cggacggaat tgtgtttgga tcacactttt ttttgatatg agcatcgtga attttctcga
    11881 taaattcagg accgatacat ctctcaaaaa tatgattttt ccactgactt ccgtggagat
    11941 tattagaaat aacaggcgaa ttatatttgt cgactataac atcaaagaag gtgcttccac
    12001 cattgtcaaa agtcgattcg gaagctgtgc aaagagcgta aacattgaat ctgtcggcat
    12061 aactgcgata cggttcatat ttcatagcgt cctgccaaag tcgtttgaca tcattgatga
    12121 atttgccctg ctgacttttt gtgtatccct cgccgcaaac gacaacaacc atattttccg
    12181 tgtcgctgcg tgttttttgg atggtataaa cagggatggt aggattagaa tattttccgt
    12241 catttgaata ccacgggccg agggtgagct gaatgctttg ctcggtgctg acattccaat
    12301 cgggatttgc gtcctcggca ggttccgaaa ttgtataatc atcctcttgc ttatttggag
    12361 cagagccgat ataaggactg ctttgtgagc cgctgccaga agttgtaaca aaatattcgg
    12421 aatcgagata aaatgcaggt cttacgccca aatcggaata ccacggagca taacgaccga
    12481 cctgacccga tgaactgata taacgcatat cgtgattgca atcggtaaca ggagtgcgaa
    12541 gccaataagg ccaagccata ccgtcattat tatacgcaac ataataacct ttgagatttt
    12601 tccacacggc attagcctgc tttacatcaa gaagaaaaac cttttcggtt gtagtttcaa
    12661 aatatgaact gtcgtagttt gccaccgctt ccgaaatatc ggtgtagtat aacaaatccg
    12721 aatttgcgtc tccatcaact atgcccttgt tgtattcggg atgagaaacg agagaacgct
    12781 gggtaacggt tttcattgcc gcaatttcag attttgaaaa agcgttgaga aaacccgctt
    12841 tttcgttgta cgctcccaca ccacttacat atccgtcttt cggagggttg ccgcaaagcc
    12901 aatcgacttt gccttcagct gcggtcgaat ttaaccaaga acgcatattg ctgtctttcc
    12961 aatagttaga accgtaatca tcacgcttat agcttctgct gtgtgatttt gaattgctgt
    13021 tgtcatttgt tttggcatca tatgcaaggg tgtcaacaat tttgtctgca agcataagcg
    13081 gtccgttatt gtcaatgctt acacatcgcc aaagaattga ggcattgtta tacgcgccca
    13141 ttttaacata gtcgccaact ttaatatcgg gctttgatgc cgcctgaatg gtcatcggca
    13201 aaacggaaat tgccatgcac aatgccaaga atattgcggt tatttttttc gtcattaagg
    13261 aacctccttt ataagctata tatttgcttt tattatattg taaggtgtta tatgtgtcaa
    13321 tgaaaatcca attaaattta tgttaatttt acagccgaca catttaatat tacacgaaga
    13381 agaaaatctt attaaatatg caaaaaggct tctgcccaaa acagggcaaa agccttaaaa
    13441 attatgcgat ttttaggttt agttgcaagc caagggggac tatttcatct gcccgaaaac
    13501 acgtttttga aaaaagtgtt gcaaaagcgg ttgaacacaa agattttcat atccgataag
    13561 cctgaatttt gcggcgcaat cggtgcggga ttgtttgccg ttgacagcga cagattgttg
    13621 gaaaggctcg aatgtaacgc cttgaacata aacccgaaaa atcttgtgat tttaatcgga
    13681 acgaatgaca tcggcatagg acttccgccc gagtacacct tgaataatat aaaagaaatt
    13741 ttgcaaagaa cgcagacact ttgctcgaat accgccgtaa aaagcagtat ccgggcataa
    13801 aaataggctg aaagtaaaac ttccagcctt gtggcagatt atatcaacct gtcaagtcac
    13861 ggtagtattt gctttgcaaa tctccacctt aaagacttga tagaacgatg ttgcgggttt
    13921 aattgcatta taaacccgta ataaggattc gaaccttaaa tgacggagtc agaggctcgc
    13981 aatctttttt caaaactgcc tatttaagcc atttttcaga ctttgcgtct accaaaaatc
    14041 tctcagaatt ttatttttgc tcagca
//
