LOCUS       gnlProkkaEMMAIJEJ_1    14315 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EMMAIJEJ_1.
ACCESSION   gnlProkkaEMMAIJEJ_1
VERSION     gnlProkkaEMMAIJEJ_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 09:42:39
            Original ID  :: gnl|Prokka|EMMAIJEJ_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 57184
            Orig. end    :: 71499
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14315
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9315]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9315
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14315
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14315
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             392..970
                     /locus_tag="ctg1_59"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMAMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             1035..1349
                     /locus_tag="ctg1_60"
                     /transl_table=11
                     /translation="MLLPGGGSAGCVYLDDLSALQRSIHEKINDLYSQRGETPEQDATL
                     CLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLLKQQLSAVCHGMQELCEIN
                     "
     CDS             1367..3778
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_61"
                     /sec_met_domain="Poly_export (E-value: 4.2e-16, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3789..4937
                     /locus_tag="ctg1_62"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5720
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_63"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.4e-14, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5741..6238
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_64"
                     /sec_met_domain="CTP_transf_like (E-value: 7.5e-12,
                     bitscore: 43.9, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPRCTFKITSSFDKCQTRSSYFG
                     SS"
     CDS             6195..7043
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 205.9;
                     E-value: 1.3e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_65"
                     /sec_met_domain="phosphonates (E-value: 5.5e-114, bitscore:
                     378.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5.5e-61, bitscore:
                     204.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINAKPVVRILEAHDGLCGLIIENQEILKGDKREVFDGMWSSSLT
                     DSTSKGKPDIEAVDLTTRLQDLNNILECTTKPIIFDGDTGGKIEHFVFTVRTLERHGIS
                     AIIIEDKVGLKKNSLFGTDVIQTQDTIEGFCNKIKAGKASQITDDFMIIARIESLIAGK
                     PVSDALERAFAYVQAGADGIMIHSKNKSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIY
                     ESELCDWGVNIIIYANHMLRAAYPAMMNVAKTILENERALEVRELCMPIKEILELIPGT
                     K"
     CDS             7060..8184
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.4;
                     E-value: 1.2e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_66"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2e-17, bitscore:
                     61.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.8e-19, bitscore:
                     65.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDYTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIARGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8194..9315
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 1.6e-33.
                     Score: 107.9. Matches aSDomain:
                     nrpspksdomains_ctg1_67_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 75.5; E-value:
                     6.4e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_67"
                     /sec_met_domain="Aminotran_5 (E-value: 4.8e-28, bitscore:
                     96.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLLVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKVSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8284..9291
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_67_Aminotran_5.1"
                     /evalue="1.60E-33"
                     /label="ctg1_67_Aminotran_5.1"
                     /locus_tag="ctg1_67"
                     /protein_end="366"
                     /protein_start="30"
                     /score="107.9"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLLVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKVSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9312..9455
                     /locus_tag="ctg1_68"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9658..11142
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_69"
                     /sec_met_domain="Polysacc_synt (E-value: 5.3e-29, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             11096..12355
                     /locus_tag="ctg1_70"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             12364..13137
                     /locus_tag="ctg1_71"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKILNNEEYLYYW"
     CDS             13112..14152
                     /locus_tag="ctg1_72"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 gaaccggatg aatttgtctt acgtaaagcg gtgcggagta ggtcagtgta tctgatttag
       61 aagcttgata tacagtgttt atcggtgtgc gttacttctt aggtaacgga atgattcatg
      121 gcgcaaagat ggacatattt atgaaaatac gcaaacaaaa atgaaattaa tttcggaaaa
      181 tgaatcaaat gcaggcataa caggcggaaa atgacaatat ccgtgttatg tctttttttt
      241 attccaattc atgaaaaaca ccttcacttc tgctttattt cctgaatacc agtcctcttc
      301 tgatgttttc gttgaaaaaa gttccctttt ctgcttgccc tatgcttgtt cgttacctaa
      361 gaagtaacgg ataaacatgg ggtaaaaaaa tatgatttta agaaaaaaga aatcactaaa
      421 tgctgggcct attaatggga caggggaagg cgtagcacac tcaaaacgct ggtatgttgc
      481 tttggttcgg atgcaccatg aaaagaaggt ttccgagcat ctggacaaga tgggtatcga
      541 gaatttcgtt cccgttcaac aggaattcca ccaatggagc gaccgtcgca agctggtcac
      601 ctccgtcttg cttcctatga tggtcttcgt acacgttgac cctaaggaac gcatggaagt
      661 cctgagtttt tctactgtca gccgttacat ggcgatgcgc ggcgagagta gtcctgctgt
      721 aattcctgac gagcagatgg ctcgtttccg tttcatgctt gattattcgg aagaatcgat
      781 aagcatgaac agttctcctt tggctcgtgg cgaaaaggtt cgcgtgatca aaggtccgtt
      841 gacgggtctt gttggcgaac tggtcaatgt ggatggtaaa agtaagattg ctgttcgctt
      901 gaatatgctg ggatgcgcct gtgttgatat gcctgtcggt tatgtagagc cgattatggc
      961 ggctgtttaa ggcaagggat atggatgcta ttattttaca agaaaatata gagggtttat
     1021 taagtttggt acgtatgctg cttcctggtg gggggagtgc aggctgcgtg tatttggatg
     1081 atctttcagc attacaacga tccatccacg aaaagattaa cgatttatat tctcaacggg
     1141 gggagacacc ggagcaggat gctaccctgt gtttggccat ccttcaggga tataatgtgt
     1201 cgatgtacgc caatccggaa gacgaagaaa gaaaacaggc tgttttgacc cgttctctgt
     1261 ctcttctcga tgttcttccc ccttctcttc ttaagcaaca gttatctgcc gtctgtcatg
     1321 ggatgcagga actgtgtgaa atcaactgaa acttttttat ttgtcaatga aaatacaacg
     1381 actttttagc attctactat tttgtttgat gctgggaagt ggctcgctta tggctcagtc
     1441 catgagtgac tcacaggtac tggaatatgt aaaagacggc atccgccaag gcaaggaaca
     1501 gaagcagctt gcttccgaac tagcccgtaa gggtgtaacc aaagaacagg caatgcgtgt
     1561 gaagcagcta tacgagcagc agaacaatgt aaatacctcg aaatcaacgg gcacggacat
     1621 caacgaatcc cgcctgcgtg aagagactaa gaagaatact tccgatatgc tggaggatca
     1681 tccgactact caggaccttg cccgtggtga tcaggtcttc ggacgtaaca tcttcaatac
     1741 ccgcaacctg acgttcgagc ctagtgtcaa ccttgccact cctgccaatt accgtcttgg
     1801 tcccggtgat gaagtcatca ttgatatctg gggtgcgagc cagaacacga tccgccagca
     1861 aatctctcct gaaggtacta tcaacattca gaagatcggc cctgtcaacc ttagcggtat
     1921 gacagtctct gccgccaatg actatctgaa gaacgccctg aataaaatat ataacggtct
     1981 gaataatact accgatccta cttccgacat ccgtctgacg ttaggtaata tccgtactat
     2041 tcagattaat gtgatgggag aagtcgtaca gcccggtacc tacgcccttt cttccttctc
     2101 taccgtcttc catgcgcttt atcgtgcagg cggtgtgagt gatatcggta gcctccgaaa
     2161 cgttcagttg gtacgcaacg gaaagaatat tgccaccatc gacgtctacg aattcattat
     2221 gaaaggcaac acacaggatg acatccgcct acaggaaggt gacgttgtga ttgttcctgc
     2281 ctatgatgta ttggtaaaga ttagcggcaa ggtaaaacgt cctatgcgtt ttgaaatgaa
     2341 gaaagacgag aaccttgcta ctctcattaa atatgccggc ggctttgaag ctgatgccta
     2401 cacccgttca ttacgtgttg tccgtcagaa tggtgaggaa tacgaagtca acacagtcaa
     2461 agatatagat tacaacattt ataaaatgcg taacggtgac gtagtaaccg ccgaagccat
     2521 ccttaaccgc ttcacaaaca aactggaaat ccgtggcgct gtctatcgtc ccggtatcta
     2581 ccagctcagc ggtaaactga acacgatccg cgaacttgtc catgaagctc agggtctgac
     2641 cggtgacgct ttcctgaatc gtgccgtcct ctatcgccag cgtgaagacc tgaccagtga
     2701 agttgttcag atagacatta agtctatcat ggacggcact tccccaaacc ttgccctaat
     2761 gaagaatgac atcctctaca ttccaagtat ccatgacctg gaagaccggg gtaatgtcac
     2821 agttcacggt gaggttgccc accctgattc ctatccttat gcggataaca tgacacttga
     2881 ggatctgatc attcaggccg gtggcttgaa agaagccgcc tctactgtcc gtattgatat
     2941 atcgagacga atcaagaatc ctcgtagtac tgcggataat gatacgattg gtcagatgta
     3001 taccttctct ttaaaggatg gttttgtaat agatggtcag cccggtttta tccttgagcc
     3061 ttatgatcag gtttatgtcc gtcgcagtcc gggctatcag gcacaacaga atgtagccat
     3121 tgaaggtgaa atccttttcg gaggaaatta cgccatgacc agccgtgagg aacgtctttc
     3181 cgatttagtg aataaagccg gcggtccgac caattatgcc tatctgcgtg gtgcgaaact
     3241 gacccgtgtg gctaacgcta gtgaaaagaa acgtatgggt gatgtaattc gccttatgag
     3301 caggcaattg ggcgaagcca tgattgactc tttgggtatt cgtgttgaag atacttttac
     3361 ggttggaata gatttggaaa aagccttgag caatcctaaa agtaatgccg atcttgtctt
     3421 acgtgaaggt gatgtgatct ccatacctaa gaatactaat actgtaacta tcaatggtgc
     3481 tgtcatggtt ccgaatacgg tttcttatat gaagggaaag aatgtggatt attacctgaa
     3541 tcaggccggt ggctgttctg ataatgcaag gaagagtaag aagttcattg tttacatgaa
     3601 tggtcaggtg acgaaggtta agggtagtgg taagaaacag attgagccgg ggtgtgagat
     3661 tattgtgcct ggtaaggcta agaagaaagg gaacatagct aatattttag gttatgctac
     3721 ttccttcagt tctttgggaa tgatgattgc ttctattgct aatttgataa agaaataaat
     3781 gacctattat gattgaaaag caatcttatc aagaaccgtt ttctgaagtg gataaaagga
     3841 aagatgatga aatggaaata gacttgatgg ctatttttta taagattatt actgttcgtg
     3901 gagtactatg caaagctgct ggagtgggag taataattgc tatagtggtg gcattgagca
     3961 ttcccaagca atatacagta aaggttaccc tttctcctga aatgggtaat gcgaagggaa
     4021 gtaatggttt agccggactt gctgcctcgt ttttgggaga tggggctcta ataggggaaa
     4081 gcacagatgc cttgaacgct tctctttcag cagatattgt ttcttcaact ccttttttat
     4141 tggaactttt agaaatggaa gtctccgttt ctaaaaagga tgataaaatg actttggggt
     4201 cttatctcga tgaagagtca tctccttggt gggattatct tataggtttt ccgggcatag
     4261 taataggagg agttaaatca ttattcggag aagatacggt tcctgccagt ggagggcggc
     4321 aaggaactat cgaattgacg aaagaagtaa atgagaagat taattttctt aaaaagaaga
     4381 ttagtgcatc cattgataag aaaaccgcca taacgagcat tacggtcacc ttacaaaatc
     4441 cgcagatcac tgcggttata gcagattctg tcgttcataa attacaggaa tatattattg
     4501 ggtatcgaac ttcaaaagta aaagaagact gtgcgtattt ggaacggttg tttaaagaac
     4561 gtcagcagga atattatgct gctcaaagaa aatatgcgga ttatgtagac gcccatgata
     4621 atgtggttct tcaaagtgta cgtgctgagc aggagcgttt acagaacgac atgagtttgg
     4681 cttatcagat atatagtcag gttgctaatc agttgcaggt atccagagcc aaagtacagg
     4741 aggaaaagcc agtctttgca gtagttgagc ctgccgttgt acctttgaaa ccttcaggta
     4801 tgggactcaa aatttatatt ttattatttg tgttcctgtc cgtatctggt actctcgtgt
     4861 gggtgctttt tggcaaaagt ctgctggcta gcttgagaaa agaactgaaa aataaggaga
     4921 tagaacagga taaatgatgc taaaacgtcg tttacaacat tcttatatca attaaattca
     4981 cttactatat tattaaacga atgatacgta cagctatgat aatggctgcg ggcatgggaa
     5041 cccgttttgg ccaatataca gaattgatac ctaaagggtt cgtcaaagtg ggaggtattc
     5101 caatgatagt tcgttctatt gatactttgt tatcatgtgg cattgagcga attgtaatcg
     5161 gtacaggata taaacaagaa gtttatgaag aattgaagac agactatcct atgcttgaaa
     5221 cctgttttag tcctcgttat gctgaaacaa atagtatgta tactttatat aatacgcggg
     5281 agattctggg caatgatgat tttttattgt tagagtcaga tttgattttt gagaaacaag
     5341 caataatgag cttattggag tgtcctgcgg cagatgcaat gctaatagct ccagtgacaa
     5401 agtttcaaga tcagtattat gtggaacatg atgataattt tcgcctttct tcatgttctg
     5461 tcaataagaa taaactaaac gctaaaggcg aattggtcgg catccataaa ctatccggtt
     5521 ccttttacaa aataatgtgt gctgattatg cgagtattgt tgatgaacaa cccaatttgg
     5581 gatatgagta tgaattacta cgaatatctt gttctcaatc tcctgtttat gtgcataaag
     5641 tagaagggct gaaatggtat gaaatcgatg acatatcaga tttggaatat gcagagaaat
     5701 atattgttcc gtattgttaa ttaaaataat atatcaaatt atgagtaaga cagtttatat
     5761 tgggatgact gcggatatta tgcatccagg acttatccgc attattaatg aggctactaa
     5821 atacggtgat gttataattg gtcttcttac agataaagct attgcggagc ataaacgcct
     5881 tccttatctg acctatgaac aacgaaaaga ggtagttcag aatattaaag gcgtatgtaa
     5941 agttgttcct caagaagaat ggagctatgt tgagaatctc aaacgcatta aacctgacta
     6001 tataattcat ggtgacgact ggaaaaccgg gcctttacgt gaagaacgtg tgcgcgtatt
     6061 tgaagtgatg aatgaacagg gaggaaaggt tatcgaaatt ccatatactt tgggaattaa
     6121 ttcatcttct ttggataaag atattaaggc tataggtaca accccccgat gtacgtttaa
     6181 aatcacttcg tcgtttgata aatgccaaac ccgtagttcg tattttggaa gctcatgatg
     6241 gactatgtgg cttgataatt gaaaatcagg aaatattaaa aggggataag agggaagtat
     6301 ttgacggaat gtggtctagt agccttacgg attcaaccag taaaggtaaa cctgatattg
     6361 aggcggttga tttaactacc cgattgcaag atttgaataa tattctggag tgtactacta
     6421 aacctattat ttttgatgga gatacaggtg gtaaaattga acatttcgta tttacagtac
     6481 gcactttaga acgtcatgga atctcagcta taataattga agataaagtt ggattaaaaa
     6541 agaattcatt gtttggtacg gatgttattc aaactcaaga tacaatcgaa ggtttctgta
     6601 ataagatcaa agcaggaaag gcatctcaga ttactgatga ttttatgatt atcgctcgta
     6661 ttgagagcct tatagcggga aagccggtaa gtgatgcttt agagagagct tttgcatatg
     6721 tccaagcggg agcggacggt attatgatac atagcaaaaa taagtcgggt gaagatataa
     6781 aagaattttg tttggcgttt cgaaaacagt atgctcatgt acctatcgtg gttgtgccta
     6841 ctacatatga tcatatttat gagtctgaat tgtgtgattg gggtgtgaat ataattattt
     6901 atgctaatca tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca aagacaatat
     6961 tagagaatga acgtgcttta gaggtgcgcg aactgtgtat gcccataaag gaaatattgg
     7021 aactgattcc gggtactaaa taaaaagagg aatatcatta tgttaagcgt agaaaaagtt
     7081 tatgaaacgt ttctgagtca tgacgttgat ttttttacag gagttccaga ctcattacta
     7141 aaaaatattt gtgcctatat cacagactat acttcacgtg agaaacatat catagctgct
     7201 aatgaaggtg cggctgtagg aattgcttca ggttattata tggcatcagg taaggttcct
     7261 gtggtttata tgcaaaattc cggcttgggt aatactgtta atcctctgct gtctcttgca
     7321 gatgaacaag tatacagttt tccaatgctt ttgatgattg gctggcgtgg tgaaccggga
     7381 acaaaagatg aacctcagca taaaaaacag ggtgaggtaa ctttagattt gttgaaagca
     7441 atgcggattc cttatataat tcttgattca aatgagaatg atgcatttat tcagctccat
     7501 gatatcatac aatcagcaaa aactaagaat attcctcatg caataattat tcggaaagat
     7561 gtttttggca aatataaact tcaaaaagaa ttcggatgta attatccttt atctcgtgag
     7621 gatgctttgc aaatagttgt ggattatctg cctgaaaatt cagtggtcgt ttctactact
     7681 ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga aagagcaagg tcatgaacat
     7741 gattttctca cggtaggctc tatgggacat agttcatcaa tctctttggg tattgctata
     7801 gcaaagcaag atagacctgt ttattgcttg gatggtgatg gagcatttat tatgcattta
     7861 ggggcaatta gtaacattgg cgatttatct cctaaaaact attatcatat tttgtttaac
     7921 aatggtgctc acgagtctgt aggaggacag cctactttag gatttagttt agatattccg
     7981 gctattgccc gggggagcgg atataagcat acttatactg tttgtacaaa agttgaaatt
     8041 gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg ttttgttgga aataaaggtt
     8101 aagatagatt ctcgggagaa tttgggacgt cccacgacta ctcctataga gaataaggag
     8161 cattttatgg attttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta
     8221 aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt
     8281 tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga
     8341 gttgctcatg ggaatttgga aaaacataca gctgtattat tttgtggctc aggaactatc
     8401 aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat
     8461 aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt
     8521 aatttggaat tttctgttta tgaacgtcct gatttattgg tagtggaaaa tgtgttacaa
     8581 gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac aggaattctg
     8641 aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat
     8701 actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt agatttttgt
     8761 atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat
     8821 gaggaacaga ttaaggtttc aaaaaaatat cccaagcgtt cttactattg taatctttat
     8881 ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact
     8941 atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggcgaaga agctaagttt
     9001 gcccgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa
     9061 agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat
     9121 cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat
     9181 ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta
     9241 gatgatattg agaacttctt taaagtacta aaagctgcat taaatcatta taacgtcaca
     9301 ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc
     9361 gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct
     9421 tagtaggcaa atatggcaat attaatttga ggtgatgcat taggagttct ttattcttat
     9481 aaaaaggcat cggtagttat aggagataat gtttgtgtag ggtaatttgc ttttagtggg
     9541 agagaccata ttagaattgc ggtaaggggc gaagaagata ataaccaatt agtgagaata
     9601 ttggaaaaat ataattgata tcggtaaatg tagttgtttt tatactgtat ttaagtaatg
     9661 gaaaatctaa agcagaaaac tgtatcagga ataatgtgga gcgctataga acgtttctct
     9721 ttacaaggag tacagtttat aattcaaata atattagctc gtttgttact accatcggat
     9781 tatggtatga tcgggatgtt agctattttt cttcaagtcg ctcaagtatt tatagatagc
     9841 ggttttacaa atgctttaat ccagaaaaaa gatagaactg aagaggattt tgccactgtc
     9901 ttttatttta atattcttgt cgcagtatta ttctatggta tattgttttt ttcggcttct
     9961 ttgattgcag acttttataa tatgccgact ttagttcttg taattcgttt tatagcattg
    10021 tcgttgataa taaatgcttt atcggctatt cacagaacga aattaattat ttctgtaaac
    10081 tttaaaactc aatctaaaat ttcattaggt gcagctttta tatcaggcgt gattggaata
    10141 tggatggctt atgtcggttg cggggtttgg gctttagttt ggcaaactct cttaaatagt
    10201 ataattttga caattttgtt ttactgttta gttcattgga aacctttaca tactttctcc
    10261 aaaagttctt ttgaaagatt attcaatttc ggatctaaat tattgatctc aagtcttatc
    10321 aatacagtat atcgtaatct gtataccatt gtaataggaa aaaagttttc tgttgtagag
    10381 cttggttact atacaagagc agaacaattt gctatttttc cttccaataa tttaaatgct
    10441 ttagtttcta gagtagcgta tcctatttta agttccattc aagatgatga taaatgttta
    10501 acaaacgcat atcgaaatta tatcagatta tcctcatata taatttttcc tttaatggta
    10561 ggtttacttg ttttggctaa tcctattatt agtctattgt taacagataa atggtctggg
    10621 gttgttattc ttttacagat attatgtttg gattggatgt ttgatcattt gagccaaatt
    10681 aatttgaatt tattatgggt taaaggaaga tctgatctgt cgttacgtct tgaaataata
    10741 aaaaagacga ttgctatatt cattcttttt gtgtcaattc catttgggct tgaggtgatg
    10801 tgttggggta gagttattta ctctctgata gcgacatatt tgaatacata ttatactaat
    10861 tctcttattg atttgacctt aaagttgcaa gttaaagatg tatttccaag tttaatactc
    10921 tctttcataa tgggggggat cgtttttata tgtatttctt tctttgaaac tgatatagta
    10981 aaaattgtga ttggatgtat tactgggatg tccttctata ttttactttc ttttcttttt
    11041 aagctagatt cttttttttg tattttaaca ttgatcatta aaactaaaaa catagatgaa
    11101 aatattaaaa aagatttttc aagtaatagt aaagataatt aaccattgtg tgccagttga
    11161 tagtagatca ttgtatttta ttcctcatcc taattgtaga acagataaat atgatattat
    11221 aaattattcg tcagataatg ttctcgttct gttaaattat ttgctaaaaa aagatagtgc
    11281 tgaatattat aaaatatatg ttgaaattta tgattcttct cgtatttcag aatatcaaga
    11341 atatatttat ggcataaatc ctaatattag gtgtactttt ttatgtgcat gtgttggacg
    11401 ttttttcttt aataaagtat cttttaagga tatgttgtat gccttttttt gtttttgtag
    11461 agcaagtaaa tgttttacag ctacttttta ttatgatttt tcatttaaaa aacgctctca
    11521 acagattatt tgtttggggt attatactcc attcaaagat gattatcata tgggagatca
    11581 ttcttatgat aaatttcgta atacaacatg taactcattt gattactcta ttgctacttc
    11641 ttgtttaagt gctagaataa tttcaataga ttgtggaatc tcatatgata aattcaaagt
    11701 cttaggattt cccagaaatg atttgttgat atcgaaaaat aattgcaatg ttattaaaag
    11761 agaaatttcg aaatttgcgg gatatgatgt aactaaatat atagtttata ctccaacttt
    11821 tcgtgattat gagactgtta ctgaaggtaa tttgcgttca atactcggat atgttgattg
    11881 tgatttgttg aagttatcga aaatactatt gaagtttaat gcggctttaa ttcttaaatt
    11941 acatcctttg cagaataaaa cagtcttaaa aaaagattta cccaaaggta tacttgtttt
    12001 tgaacaaaca tataaatatg gattgtatga tcttttgtca ttttcagatg gaatgattac
    12061 tgattatact tctacctatt ttgatttttt attggtaaat aagccagtca tatttaattt
    12121 ctacgatatt gaagaatatc gtagagtaag aggtttctca tttgagccaa tagaattttt
    12181 ttgtgcaggt gatattgttt acaattataa tgaattgata gatgctgtga tgggacttct
    12241 ggctgggaaa gatattcatg ctgaacatcg acgtcatatt tctttattga tgaatcaatt
    12301 tcaagatgat aattcaacaa agagaatatg tgacatattt ttaaatgaaa tataataaat
    12361 aaaatgaatt atgcatttgt ggtgcaggca cgtttaggtt ctacacgttt gcctggaaaa
    12421 atattgaaac ctttctatgg taatcaatcg attcttgact taatggttca taagctttct
    12481 gctatatcga atattccagt aattattgct acaacaaatt ctgttatcaa tgaacctatt
    12541 gaaaagaagg cacttgcatt aggggtaaag tgcttcagag gtgaggagaa tgatgtttta
    12601 aaacgattca ttgatgttgc tgaatatttt gatatacagg gtatattccg aatatgttct
    12661 gataatccat ttttagatgt acatgcggca aggcaattgg tcgaaatagc aatgaaatct
    12721 tgtaacgatt atataagttt tgatattgat ggtactccat caattaaaac tcatttcggt
    12781 ttttggggag aatttgtaac gcttgatgcg ctgaagcgag ttataggatt tactgatgat
    12841 ttattgtatc gtgaacatgt tactaattat atatatagtc atcctgaact ttttaatatt
    12901 caatggattt caggatctcc agtcgtgtca aaacatcata atattcgact cacgattgat
    12961 acgttagaag atttttctgt agcacagaga atatataggg atttacaaga aaaaagagtg
    13021 gaaatatcga tagaagtgat tgtagactat gttcgaagac atgcagaata cattcaactg
    13081 atgaaacaac aaataaaaaa aattctaaat aatgaagaat acttatatta ttggtgaaat
    13141 agggcagaat cataatggtt ctgttgactt ggctaagttg attattgaat taatctcacg
    13201 acctgtacat gaggatgttt ttggtatgga tttcatgcca atgaatgctg ttaaaatgac
    13261 taaaagagat ttatcagaag aattggctgt ttctcaaatg aatcaaatat atgacaatcc
    13321 taattctttt gggcgtactt atggtgaaca tcgtgctttt cttgagcttg atgatcaagc
    13381 gcattttgag atttataaat atgctaagtc attaggatta gattttatcg agacgttatg
    13441 tgccaaagga tgtctgtctt tgcttaaact gttcacaccg gataggctaa aagttgctag
    13501 tcgtgatttg actaacttac cattgcttga agcattagca gaaactcata ttcctattat
    13561 attatcgaca ggaatggctg gtcaaagaga acttgacaat gcattagatg tgataacgag
    13621 atatcatagt aatatagcta ttctacattg tgtatctcag tatccaactc atccaaataa
    13681 tttgaatcta cgtacaataa catatttgaa gaagcattac aataagtttg agataggttt
    13741 ttctgatcat acaataggta tttctgctgc tacagctgct gtagcgatgg gagcggaaat
    13801 tatagaaaag catgtaacaa ttgatcggca tatgaaagga acagaccagc ttggctcttt
    13861 aggtccagat ggggttaatc gtatgattcg agatattcgc atagcagagt gttggcttgg
    13921 tactgaagat ctttatatag aaaaaggggt ggagaagtct aagataaaac ttgaacgttc
    13981 tattgccact cgaaaatata ttccagcagg tagtattatt caagagtcgg acattcattt
    14041 actgagtcct ggtgatggtt ataaatggat agataaaaaa aatgtaattg gtcattttgc
    14101 taaacaagat atatcagcga atgaaataat atatcctgat tttattgaat agatatattc
    14161 ctactgcaac ttgtattacg gtatagagta ctgcctgcta taagctaagt agtgattaat
    14221 aaataagggt aaaatactaa aaaaatgaaa gagataaagc ttatacttac agatattgat
    14281 ggcgtttgga ctgatggcgg aatgttttat gatca
//
