LOCUS       gnlProkkaJPGMEENA_77   13558 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JPGMEENA_77.
ACCESSION   gnlProkkaJPGMEENA_77
VERSION     gnlProkkaJPGMEENA_77
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:15:23
            Original ID  :: gnl|Prokka|JPGMEENA_77
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 45317
            Orig. end    :: 58875
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13558
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8558]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8558
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13558
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13558
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(622..1401)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_50"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-16,
                     bitscore: 54.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTQPNSGLSVARNNGLLHAKGKYVWFVDSDDWILENCLQEIAGY
                     MVAGIDIITFCAADFINDKFYRRFEYITGVNKKIEGRDLLKRGTCQHCVPFSIYRKRFL
                     EQNHLFFLPNIFHEDTEFSPRAYYLANHVFCINKVFYYVYHNPNSITRTFNPKKSFDLL
                     IVSHSLSIFMLDVTPEYKSCFNNLISLSINAAINGIVTAKSEISRFIVDLTARGLYRNM
                     LNAGKLRYKIEGLLLYLCPALLICLYKHYSSLRRIIK"
     CDS             complement(1621..2946)
                     /locus_tag="ctg69_51"
                     /transl_table=11
                     /translation="MLIVILLTLILIYILYKIYKKKKVHQFLLIYFAFSAFLWVIFPSI
                     VSLIGDRYKQELVVKENVFITYAIYEFLFYIILLLLLYRFPLCKPFYYGKYIPNTSSSI
                     KRIWFVLSLFLIINIIKQISSNVTYSEVNDSTILAEQETNLFSIFSNFSICLYLTIILF
                     YNKLYSKRIIFFSWLLLSLNIITVLAHGARMQVIFYLFVFVYYLFSSALNKKRFFLYMS
                     FLIGIIYLCSYILPAVAYIRSGGNFTVEDLRKSYENYGEANAFVLQLLIKSNSINTGAI
                     LVEETKEKPYLNPYINSIYSFCPSILFPGKRPLAGSSDGTIDGFPTRLAAEYISGDSRF
                     FNVGISTSATALWHGGILFYVINLIIVFFWYRFLNSLMFYENYYAKLLVVYFTVLGYFI
                     LPTADVLIRDLLKQPFFYAFFIFISRGGLIKDWVRSLKRHIA"
     CDS             complement(2961..3746)
                     /locus_tag="ctg69_52"
                     /transl_table=11
                     /translation="MEKISNYNTDGTMLRKQQERMFEMLCVIDDICVKNEINYWLSGGT
                     LLGAVRHGGFIPWDDDLDIQLMKDDYNKLLGLLKTELPEQYQLQTSKTDRNYFARYAKV
                     RDVNSLLEDSDYTLGYKYKGIFIDIFSVEKANKFLVKISAFMQWYLLISLLPMVHKKTK
                     MQLNLFSLWNKFLGTFYSGFRLFGKLFAKKINYSYGVYYPLNCDYTTIFPLTTIEFEGR
                     MFKVPGNYNLYLCNIYGDYMKLPPEEERENHNIRVVHIV"
     CDS             complement(3751..4995)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg69_53"
                     /sec_met_domain="Polysacc_synt (E-value: 1.6e-36, bitscore:
                     119.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKKSLDSYKVIFQNTFYLSIIEAIRLIMPFIALPYIITTIGAT
                     NYGIIIFSQTIVSYFSIVINWGLDVTSVREVSLNRGSLKKMSLIVSTVFTIKFILFGLC
                     FSIFMICLFFIPFFQQYRIIYLYAFLSCFSEVIIPVWFFQGIEKMKYLTYIRTTSIVLY
                     TILVFTFIKKEMDFTLLALLQSLANITAGVFSLILLLIFCRVKFVFPTFRVMKETFCNS
                     TPFFVSRVSFLLNTNIAKTMSGLFLNMHTVAAFDLSQKILSFVSVPIQMLNQAIYPHVA
                     KNPIKSFSVKMLYVIAALSLILSVLLFFLAPYIILYFSAQLYAEALIFIRILCLYVFCF
                     GINTYLGTPLLVAYGFYKPFNFSVIYSTLFVCSLYGILYVFNLLGGECFALAMFLTELF
                     ILIYRFYYCLKFKLI"
     CDS             complement(5001..5978)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_54"
                     /sec_met_domain="Fe-ADH (E-value: 2.2e-75, bitscore: 247.4,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGVQIFEFHDFEENPKIEDLDRGLLQLRVYHPDLILAIGGGS
                     VLDMAKLLRFFYSYSGNKIGRVFEKIENLLPLIVIPTTAGTGSEATSFAVLYKNKVKYS
                     VSHEDILPEIAFIDPYFTYNISRYLTACTGFDALAQAIEAYWNLNATNESDVFAVKAIK
                     LLWPNLPLAVNNPTKEVRNSMSEGAYWAGCAINITKTTAPHAFSYPFTTYYGYPHGHAV
                     ALTFPFFMEYNVGSILLKHGTVFDKMIRLMEILNITNVNECKSLLCDYIENIGLDLKLP
                     ANFDHRIILSNINVQRLSNNPVRIDGAVAKTALNTLCIKDDDKD"
     CDS             complement(6032..6121)
                     /locus_tag="ctg69_55"
                     /transl_table=11
                     /translation="MKQRIYIGEASLNNLDIILQEYSAKKVFW"
     CDS             complement(6123..7250)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 67.8;
                     E-value: 1.3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_56"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.9e-18, bitscore:
                     58.0, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     67.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPELFINSLVQNELNFFTGVPDSLLKHICAYITDHIASNSHIV
                     AANEGAAIGLAVGYHLATNKIPVVYMQNSGIGNSINPLLSLVDKEVYNIPLLLLVGWRG
                     EPGVKDEPQHIKQGKVTIPLFDSMRIKNQILSKDKSDFLQQLNVALEYIRETNEPFVFI
                     IQKETFSDYKLQTPNNNALLLDRETAIKIIVSSISKNDIVVSTTGMISRELFEYRDNMG
                     ESHEKDFLTVGSMGHASQIALGIALQKKARTVYCFDGDGAVLMHMGGLTTIGSIKPSNY
                     IHVLFNNGAHDSVGGQPTVGFEVDFTKIALACGYKYALVVESASSLNEVLKTVNEMQGP
                     VFLEVKVKKGARKDLGRPTITPIQNKDSFMDFLKR"
     CDS             complement(7258..7656)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 96.7;
                     E-value: 2e-29)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_57"
                     /sec_met_domain="phosphonates (E-value: 9.3e-51, bitscore:
                     166.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.6e-31, bitscore:
                     100.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIARIESFIAGKGLDDAMKRALAYIEAGADGIMIHSKDKSGEDI
                     RLFCKALREVNQSIPIVVVPTTYNHITDEELSTWGINVVIYANHMLRSAYPAMLNTAKS
                     ILLHARSYEANDLCMPVKDILELIPGTK"
     CDS             complement(7812..8558)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg69_58"
                     /sec_met_domain="CTP_transf_like (E-value: 1e-15, bitscore:
                     51.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-09, bitscore:
                     31.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKVYVGMSADIIHPGHLNIIHEAQKLGNVTVGVLTDAAIASYK
                     RLPYLTYEQRSLIVQNLKGVDEVIPQTTLDYIPNLELLKPDFVVHGDDWKEGVQKETRQ
                     RVIETLSKWGGQVIDIPYTQGISSTKLNSKLKEIGTTPEVRLKRLKRLIEAKSIVRICE
                     SHSGLTGLIIENTSVEVNGMKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLMMLW
                     NVQRNLLFLMVIQEEKLNILFLQFVR"
     CDS             complement(8561..9034)
                     /locus_tag="ctg69_59"
                     /transl_table=11
                     /translation="MTQIHELQHVAHELLYLGADGSPIYTDSFRQLNTEVLQKSDALFA
                     LKGENPEEEARLCLALLMGYNATIYDYGDKESKKQVILDRSLLVLESLPSSLLKCQLLT
                     YCYGEVFEEELAKEAHAIIDGWKDRELLEEEREIVENLRILEEPPYLFSNKSC"
     CDS             complement(9070..9588)
                     /locus_tag="ctg69_60"
                     /transl_table=11
                     /translation="MSQQQEYWFAARTRKDQELTTRDALEKIGVEYFLPTQFVIRQLKY
                     RRRRVEVPVIRNLIFVHATKEFACAIANEYGVRLFYMRDFDTKSMLIVPDKQMKDFMFV
                     MNLDPAAVILNDDCFAVGTKVQVIKGDFCGVEGELASLSNRTYVTIRIRGVLSASVKVP
                     KSYLRILAP"
     CDS             complement(10729..13218)
                     /locus_tag="ctg69_61"
                     /transl_table=11
                     /translation="MSLAPDKLHTLIASGDVYIRSEKPLQSIPEADVVCYGLWVDPSLA
                     THHGVFASDRKHPEQLDFMLQKPSLAELESLSKTHLFLMDIGIWLLSDRAVEILMKRSH
                     KESSEELKYYDLYSDFGLALGTHPRIEDEEVNTLSVAILPLPGGEFYHYGTSKELISST
                     LSVQNKVYDQRRIMHRKVKPNPAMFVQNAVVRIPLCAENADLWIENSHIGPKWKIASRH
                     IITGVPENDWSLAVPAGVCVDVVPMGDKGFVARPYGLDDVFKGDLRDSKTTLTGIPFGE
                     WMSKRGLSYTDLKGRTDDLQASSVFPMVNSVEELGLVLRWMLSEPELEEGKNIWLRSER
                     FSADEISAGANLKRLYAQREEFRKGNWKALAVNHEKSVFYQLDLADAAEDFVRLGLDMP
                     ELLPEDALQMSRIHNRMLRARILKLDGKDYRPEEQAAFDLLRDGLLDGISNRKSTPKLD
                     VYSDQIVWGRSPVRIDMAGGWTDTPPYSLYSGGNVVNLAIELNGQPPLQVYVKPCKDFH
                     IVLRSIDMGAMEIVSTFDELQDYKKIGSPFSIPKAALSLAGFAPAFSAVSYASLEEQLK
                     DFGAGIEVTLLAAIPAGSGLGTSSILASTVLGAINDFCGLAWDKNEICQRTLVLEQLLT
                     TGGGWQDQYGGVLQGVKLLQTEAGFAQSPLVRWLPDHLFTHPEYKDCHLLYYTGITRTA
                     KGILAEIVSSMFLNSSLHLNLLSEMKAHALDMNEAIQRGSFVEFGRLVGKTWEQNKALD
                     SGTNPPAVEAIIDLIKDYTLGYKLPGAGGGGYLYMVAKDPQAAVRIRKILTENAPNPRA
                     RFVEMTLSDKGFQVSRS"
ORIGIN
        1 agaaggggct ttatgagtac cgttaaccaa cactgaatta taaacagaat caacaatgtc
       61 agcaatctca ggagtcgaac cggaagttac tttcttaatc ttttcaacag tatgctcttt
      121 atcacccggg tttatacgtt ctggtgaata acctgcataa aaatctacat tgtatgttaa
      181 cccagacacc tcttcgacta ccggaagaca ttcttcctct gttactcccg gatatacagt
      241 agattcatac acaacaatat ccccttttga aataactttt ccgactgttg tactcgcacc
      301 aatcaaaggt gtaagatcgg gacgattatt caaatccaca ggggttggta cagctacaac
      361 ataaaagtta caattactta tttcgtcaat attactggta catttgaaac cattttctaa
      421 cgctttccga agtaagtcat cagaaacctc taaagtcata tcatgaccgg aatttaaagc
      481 atcaacacga gactggttca gatcaaaacc aatacattca tattttgtcg aaaacaatcg
      541 ggccaaaggt agcccgacat aaccaagacc tattacggca atcttaattg gtttaacaaa
      601 caccataaca tttttattag attatttaat aattcttctc aatgaagagt aatgtttata
      661 cagacaaatc aacaatgccg gacataaata gagtagtaat ccttctattt tataccttaa
      721 ttttccggca ttaagcatgt ttcgatacaa tcctctagca gttaaatcca ctataaacct
      781 agaaatctcg ctttttgccg taacaatgcc atttattgca gcatttatag acaaagaaat
      841 caaattatta aaacaagatt tatactcagg agtaacatcc aacatgaata tagacaagct
      901 gtgagataca attaataaat caaaagactt tttcggatta aatgttcttg ttattgaatt
      961 aggattatga tacacataat aaaatacctt attaatacaa aaaacatgat tcgctaaata
     1021 atatgcccgt ggagaaaatt ctgtatcttc atgaaaaata tttggcaaaa agaacaaatg
     1081 attttgttct aaaaatcttt tccgatatat agaaaatggc acacaatgtt gacaagttcc
     1141 tctttttaat aaatcccttc cttcgatttt tttatttaca cctgttatgt attcaaatct
     1201 ccgataaaat ttatcattaa taaagtctgc agcacagaaa gtaataatat caattccagc
     1261 aaccatataa cctgcaatct cttgaaggca attttctaaa atccagtcat cggaatcaac
     1321 aaaccaaaca tatttacctt ttgcatgtag taatccatta tttcgtgcaa cgcttaatcc
     1381 actattaggc tgagttaaca aagttatatt ttttctatct aaccattttg aaatcttatc
     1441 gatactgcta tctgggcttc catcatctat taaatgattt catattgtga tattgaaaga
     1501 tcttgattca aacaacttaa tagacaacgt tcaatatata actcaacatt atatacaggg
     1561 attacaatag ataaaagtat gggattattc atgatgataa attcaaagaa tatcttttca
     1621 ctaagcaata tgacgtttca aagatctaac ccaatcttta ataagaccac ctctcgagat
     1681 aaatataaag aatgcataaa agaaaggctg tttaagcaaa tcccgtatta agacatctgc
     1741 cgtaggaagt ataaaatacc ccaaaactgt aaaatataca actaaaagtt ttgcatagta
     1801 gttttcataa aacattaatg aattcagaaa acgataccaa aaaaaaacta taattaaatt
     1861 aatcacataa aataaaatac caccatgcca tagtgccgtg gcagaagttg atattcccac
     1921 attaaagaaa cgagaatcac cacttatata ttctgcggct aatcttgtag ggaatccatc
     1981 aatcgtacca tcactactac ctgccaaagg tctttttcca ggaaagagta tacttgggca
     2041 gaatgaatat attgaattaa tatatggatt caagtatggc ttttcttttg tttcctcaac
     2101 taaaatggcc ccagtattta tactattaga cttaatcagc aattgaagga caaaagcatt
     2161 tgcttcccca taattctcat atgactttct caaatcctca actgtaaaat ttcctcctga
     2221 ccttatatat gcaactgccg gaagaatata agaacataaa taaataattc cgatcagaaa
     2281 agacatatat aagaaaaaac gttttttatt taatgcagaa gaaaataaat aatatacaaa
     2341 aacaaacaaa taaaaaataa cttgcattct tgctccatga gctaaaaccg ttattatatt
     2401 aagagatagt aatagccaag agaaaaaaat gattcttttt gaataaagct tattgtaaaa
     2461 taatattata gtaagatata ggcatataga gaaatttgaa aaaattgaaa ataaattagt
     2521 ttcctgttca gccaatatag ttgaatcatt gacttcagaa taagtaacat tggaagatat
     2581 ctgcttgata atattaataa tgagaaaaag acttaataca aaccatattc gttttataga
     2641 cgaggatgta ttgggaatat atttcccata atagaaaggt ttacataatg gaaaacgata
     2701 gagtaaaagt aacaatatta tataaaaaag aaattcataa atagcataag ttataaaaac
     2761 attttctttt actaccaatt cctgtttata tctatctcct attaaagaaa caatcgatgg
     2821 aaaaataacc cacaaaaaag cagaaaaagc aaaatatatg agtaaaaatt gatgaacctt
     2881 ctttttttta tatatcttat ataatatata tattaagatt agagtcagta gtattactat
     2941 taacataaat atagtgagaa ctaaacaata tgaaccactc ttatattatg attttctctt
     3001 tcttcctctg gaggaagttt catataatca ccatatatat tacataaata taaattataa
     3061 tttcccggaa ctttaaacat acgtccttca aactcaattg ttgttaatgg aaatatagta
     3121 gtataatcac aatttaaagg atagtaaact ccataagaat aattaatttt cttggcaaac
     3181 aatttaccaa atagtctgaa tccagaataa aaagtaccta aaaacttatt ccataatgaa
     3241 aaaagattca attgcatttt agttttctta tgtaccatag gtaacaaaga gatcaataga
     3301 taccattgca taaaagcaga tatctttact agaaatttat ttgctttttc aacagaaaaa
     3361 atatctataa atatcccttt atatttatat cccaaagtat aatcactatc ttcaagcaaa
     3421 gaattcacat ctcttacttt cgcatatctt gcgaaatagt ttctatcagt cttagatgtt
     3481 tgtaactggt attgttcagg aagttctgtc tttaataaac ctagtaattt attatagtca
     3541 tctttcatca gttgaatatc taaatcatca tcccatggta taaaacctcc atgcctaaca
     3601 gctcctaaaa gagttccacc agataaccaa taattaattt cattcttgac acaaatatca
     3661 tctattacac ataacatttc gaacatacgt tcttgttgct ttcgcaacat agtaccatca
     3721 gtattatagt tagatatctt ttccattatt ttatatcaat ttaaatttca aacaataata
     3781 aaatctatat atcagaataa aaagctctgt taagaacatt gctaaagcaa agcactcccc
     3841 acccaataaa ttaaatacgt ataaaatccc gtacaaagag cacacaaata aagtagaata
     3901 tattacactg aagttaaatg gcttataaaa accataagcg acaagaagtg gagtccctaa
     3961 ataagtatta ataccaaaac aaaatacata aagacacaag atccttataa aaattagagc
     4021 ttcagcatat agttgcgctg aaaaataaag aatgatatag ggtgctagaa aaaaaagtaa
     4081 aacagataaa atcaaagata atgcagctat aacatatagc atctttacag aaaatgattt
     4141 aattggattt tttgcaacat gaggataaat cgcctgattc agcatttgta tgggaacaga
     4201 cacaaaagat aaaattttct gagacaaatc aaatgcggca acagtatgca tattcagaaa
     4261 taacccactc atcgttttag ctatattcgt attcaataaa aacgaaactc tggaaacgaa
     4321 aaacggtgta ctattacaaa aagtttcttt catcactctg aaagtaggaa atacaaattt
     4381 gactctacaa aaaattaata ataatattaa tgaaaataca cctgcagtaa tattagccaa
     4441 agattgtaat aaggctaaaa gtgtaaagtc catttctttt ttaataaaag taaaaacaag
     4501 tatagtatag agaactatac ttgttgtcct tatataagtc aaatacttca tcttctcaat
     4561 accttgaaaa aaccacacag gtataataac ctcagaaaag catgacaaaa aagcatacag
     4621 atatataatt ctatattgtt gaaagaaagg gataaaaaac aaacatatca tgaaaataga
     4681 aaagcaaagt ccaaacaaaa taaatttaat agtaaataca gtagaaacga ttaaactcat
     4741 tttttttaaa ctacctctat ttaaagacac ttctcggact gaagttacat ctaatcccca
     4801 attaataaca attgaaaaat atgaaacaat cgtttgagaa aaaatgataa tcccataatt
     4861 agttgcgcca atagtagtaa taatatatgg aagagcgata aagggcatta ttaagcgtat
     4921 agcttcaatt atcgacaaat aaaatgtatt ttgaaaaatt actttatagg aatctaaaga
     4981 ctttttaatt ttcatcacta tcaatcttta tcatcatcct tgatacataa agtatttaaa
     5041 gctgttttag ccacagcccc atctattcgt acagggttat tactcaacct ttgcacattt
     5101 atatttgaaa gaataattcg atgatcaaaa ttggcaggca actttaaatc aagtccgata
     5161 ttttctatat aatcacatag taaagatttg cattcattta cattggttat attgagtatt
     5221 tccatcaatc gaatcatttt atcgaaaact gtaccatgct ttaataatat acttcctaca
     5281 ttatattcca taaaaaatgg gaaagttaat gccaccgcat gtccatgtgg atagccataa
     5341 taagtagtaa atggataaga aaaagcatga ggtgctgtag tcttcgttat atttattgca
     5401 catccagccc aataggcccc ttcagacata ctgtttctaa cctcttttgt tggattattt
     5461 accgctaatg gtaaattagg ccaaagtaat tttattgctt ttactgcaaa aacatcagat
     5521 tcatttgtag catttaaatt ccaataagct tcaatagcct gggccaatgc atcaaacccc
     5581 gtgcaagctg tcaaatatcg agaaatatta tatgtaaaat atggatcaat aaaagctatt
     5641 tcaggtaata tatcttcatg cgaaacagaa tacttaactt tattcttata taacacagca
     5701 aaactcgtag cctcactgcc agttcccgca gttgtaggta taacaattaa aggtaataga
     5761 ttttctattt tttcaaaaac tcttcctatt ttatttccag aataagaata aaaaaaacga
     5821 agcaatttag ccatatccaa tacactgcct cctcctattg caagtatcaa atctggatga
     5881 taaactctta attgcaaaag tcctctatct aaatcttcta ttttaggatt ttcctcaaaa
     5941 tcatggaatt caaagatctg aactcctact ttcttcaata tagagtttaa tcttgattgt
     6001 gctccacaaa gctcatatga tttcttccct ctcaccaaaa aaccttcttt gcagaatatt
     6061 cctgcaaaat aatatctaaa ttattcaatg aggcctctcc aatatatatg cgttgtttca
     6121 tattatcgct ttaaaaagtc cataaaagag tctttatttt gtattggagt tattgtagga
     6181 cgacctaaat cttttcgagc acctttcttt accttaacct ccaaaaaaac aggtccttgc
     6241 atttcattca ccgttttaag aacttcgttt aaagatgaag cactctccac aaccaaagca
     6301 tatttataac cgcacgccaa agctatcttt gtaaagtcta cctcaaaacc aaccgtaggt
     6361 tgcccaccta cagaatcatg cgctccatta ttaaataata catggatgta attagacggt
     6421 tttattgatc caatggttgt tagtcctccc atatgcatta aaacagcacc atcaccatca
     6481 aaacaataca cagttctagc ctttttttgt aatgcaatac ccaaagctat ttgagaggca
     6541 tgccccatag aaccgactgt taaaaagtcc ttttcatgag attcgcccat gttatcccta
     6601 tattcaaata gctcacgaga tatcattcct gtagtagaaa cgactatatc attcttagaa
     6661 atagaagaaa caataatctt aatagcagtt tctctatcca ataacaaagc attattattt
     6721 ggagtttgca gtttataatc actgaatgtt tctttctgaa ttataaaaac aaaaggctca
     6781 tttgtctctc ttatatattc taatgctacg tttagttgtt gtaagaaatc agatttatct
     6841 ttggaaagta tctggttctt tattcgcata gaatcaaaca aaggaatagt taccttacct
     6901 tgttttatat gttgaggttc atcctttaca ccaggctcac ctctccaacc gactaataat
     6961 aataaaggaa tattatacac ctccttgtct actaaagata ataaaggatt aatagaatta
     7021 ccaataccgg aattttgcat atatacaacc ggaattttat tagttgccaa atgataacca
     7081 acagccaaac caatcgctgc tccctcattg gcagcaacta tatgactatt tgaagctata
     7141 tgatcagtta tataggcaca aatatgtttc aataatgagt ctggtacccc tgtaaaaaaa
     7201 ttaagttcat tttgtacaag agagttaatg aaaagttctg gagaaatcat aaaaaaacta
     7261 ttttgtacct ggtattaatt ctaatatatc ttttactggc atacataaat catttgcctc
     7321 atatgaacgg gcatgtaata atatagattt cgcagtattt agcatagcag gataagcact
     7381 acgtaacata tggtttgcat aaatgaccac atttataccc catgtagaca actcttcatc
     7441 tgttatatga ttataagttg tcggaactac tactatagga attgattgat taacctctcg
     7501 taacgcctta caaaaaagtc taatatcttc acctgattta tctttactgt gaatcattat
     7561 accatcagct cccgcctcaa tataagctaa tgctcttttc atagcatcat ctaaaccttt
     7621 accagcaata aaactttcaa ttctggcaat aatcataaag tcatccgtta tttgagcacg
     7681 ttttcctgct gatattttat cgcaaaaacc ctcaattgta tcttgtgtct gaataacatc
     7741 agttccaaat aaagaattct ttttcaatcc aactttatct tcaattatta tagcagaaat
     7801 acccaaacgt tctaacgtac gaactgtaaa aacaaaatgt tcaatttttc ctcctgtatc
     7861 accatcaaaa ataacaggtt tcgttgtaca ttccaaagca tcattaaatc atgtaaacgg
     7921 gtcgtcaaat ctacagcttc aatatcaggc ttcccctttg atgttgaatc agttaaacta
     7981 ctagaccaca ttccatcaaa ttcacgcttc ataccattta cctcaacaga cgtattttct
     8041 atgattaacc ccgttaatcc actatgtgat tcacaaatac gaacaatgga cttagcttca
     8101 atcaaacgtt ttaatctttt caaacgcact tcaggagttg tccctatttc tttaagcttt
     8161 gaattgagtt ttgttgagga tataccttgt gtataaggta tatcaataac ttgtccgccc
     8221 catttagaaa gagtttcaat aacccgttgt cttgtttcct tctgaacgcc ttctttccaa
     8281 tcatctccat gaacaacaaa atcaggtttt agcaattcaa gattaggaat ataatctaag
     8341 gtagtttgtg gaataacttc atcaacacct tttagatttt gtactattaa ggaacgttgt
     8401 tcataagtta aataaggtaa acgtttataa ctggctatag cagcatctgt taaaacacct
     8461 acagtcacat tccctagttt ttgtgcttca tgaataatat tcaaatgccc tggatgaata
     8521 atatcagcac tcatcccaac atatactttc tttttcattt ctaacaagat ttattactaa
     8581 acagatatgg aggttcttcc aaaatcctca aattttcaac tatttctctt tcttcttcta
     8641 acaattctcg atctttccaa ccatctataa ttgcatgagc ttcctttgcc aactcttctt
     8701 caaaaacttc tccataacaa tatgtcaaaa gctgacactt gagcaaagaa gacgggagag
     8761 actctaacac aagcaaggaa cgatccagaa taacctgttt cttagactcc ttgtcgccat
     8821 aatcatagat tgttgcattg tagcccatca agagagccag gcaaagtcgt gcttcttctt
     8881 ccggattttc tcctttcaaa gcaaacaaag catcagattt ttgaagcact tcagtgttta
     8941 attgacggaa actgtcggta tagataggag aaccgtcagc acccaaatac aataattcgt
     9001 gagccacatg ttgcagctca tgaatctggg tcataagagt attcatttta tatgataaaa
     9061 tattactgat tacggtgcga gaatgcgaag gtagctttta ggaaccttga cactggcaga
     9121 taaaacgcca cgaattcgga tagtgacata agtacgatta gaaagactgg ccagttcacc
     9181 ttcaactcca caaaaatctc ccttgatgac ttgtactttg gtgccaactg cgaaacaatc
     9241 atcgttgagg ataacagcag caggatcgag attcatgaca aacataaaat ctttcatctg
     9301 cttatcggga acaataagca tactcttagt gtcaaaatca cgcatataga aaagacgcac
     9361 cccgtattca ttggcaatag cacaagcaaa ctctttggta gcatgtacaa aaataagatt
     9421 acgaatgaca ggaacttcta cacgacgccg gcgatatttc aattgacgaa tgacaaattg
     9481 ggtcggcaaa aaatactcga cacctatttt ctctaatgcg tcacgagtag taagctcctg
     9541 atccttacgg gtacgggcag cgaaccaata ttcttgttgt tgagacattt agaaggaata
     9601 ttcctaagtg atttacttaa gtccgggtat gcttcgcagt tgggtgagac tctttttctc
     9661 agccaaactg caagattttt tatgacttat tttaggtgga aacgaacgga ttcgatcaat
     9721 tgatgtttca aaaaacgttc gtcttttgaa acatcaatta tggagataaa agcccacata
     9781 caaaataagt aaaaagctgt ttttattacc agattattat ctgataatca gtacataaag
     9841 aagtctattt agtttttcat ctaaaaatat tttgcacatc aaaatttagt ttataccttt
     9901 gtgctattaa acgaacgtct tttgaaacac attcactgct gattatcagt taattacaaa
     9961 agaaatcacc ctttttatcc ttttcacatt tgccacacaa catactgatt ataaataaat
    10021 tacacaataa gataaactct tcattattct atctataaag gtttagaaac tatatactcc
    10081 caaaagcatt ctgtcacatt gtattttgag tagcctcagg aatcccttat ttacggacca
    10141 ctgactaagt tgttataaaa aacaccggga ttctattttc accaatatca tatctccacc
    10201 aaataaatca aatcaccagt caaaagatcg ataaacatgc actaatttca atcagtaagc
    10261 aacggaaaag gcatcctata cctccaaaat aacattcagg aatgattcat attgacctat
    10321 gctacagaaa agaattctat agttcttgtt caataaatga aaccgctagg caaaaagtag
    10381 gaggattttc aatgaaaatg aatttcgtaa ctatacgaag ttaacttcgt attttcttat
    10441 aactaacttc ttcttcacaa gaagttaatg ttttgcaaag acgaagttaa cttcgtatga
    10501 agagtacacg tacgaagaaa cgaattaaag gcaagttact gctccatcat ttgctatttc
    10561 atcactttct caagacaaca aggtttttaa aacaagaaaa aagcagactt aaagatatca
    10621 ggatctctat tttactatca gaataacaga agaggcaaac ttaatgagga atggaaaaag
    10681 aagtcgacga gagataaaac ccttacctct cgtcaaccaa tactattttt atgatcgtga
    10741 tacttggaat cccttatcag ataacgtcat ttcaacaaaa cgtgcccgcg gattcggagc
    10801 gttttctgtc agtatcttac gaatacgaac agcagcttgc ggatctttcg ctaccatata
    10861 taagtacccg ccaccaccgg ctcccggcaa tttatatccc aaggtataat cttttatcag
    10921 atcgataatt gcctccacag ccggaggatt tgttccgcta tccaatgctt tgttttgttc
    10981 ccaggttttt cctaccaaac ggccaaactc aacaaaactt ccacgctgta tagcttcatt
    11041 catatccaat gcatgcgcct tcatttccga gagtaaattg agatgcaacg atgaattgag
    11101 gaacatggaa ctgactattt ctgccaagat cccttttgcc gtacgagtta taccggtata
    11161 ataaagcaag tgacagtctt tgtattcagg atgcgtaaat aaatgatcgg gtagccaacg
    11221 caccaatgga ctttgagcaa agccggcctc ggtctgaaga agcttcacac cctgcaacac
    11281 acctccatac tgatcctgcc atccaccacc ggtagtcagc aattgttcaa ggacaagagt
    11341 acgttgacaa atctcatttt tatcccaggc taaaccacag aaatcgttaa tggcaccaag
    11401 tacggtagaa gccagaatgg aactggtgcc caaaccggaa ccggcaggaa tagcagccaa
    11461 taaagtcact tcaatacctg caccgaaatc tttaagctgt tcttctaatg aagcataaga
    11521 tacagcagaa aacgcaggtg caaagcctgc caatgacaga gcggctttcg gaatagagaa
    11581 aggtgaaccg atcttcttat aatcttgcaa ttcatcaaac gtagatacta tttccatagc
    11641 acccatatcg atagaacgca ggacgatatg gaaatcttta cacggcttca catagacctg
    11701 taagggaggt tgtccgttca actcaatagc cagattcacc acatttcctc ccgaataaag
    11761 tgaataagga ggagtatcgg tccatccacc tgccatatcg atgcgcacgg gactacgtcc
    11821 ccaaacaatc tgatcggaat atacatccaa ttttggggta ctcttacgat tactgatccc
    11881 gtccagcaag ccgtcacgaa gcaaatcaaa agcagcctgt tcttccggac gataatcttt
    11941 cccgtctaat ttcaaaatac gcgcacgcaa catccggtta tggatgcgtg acatctgcag
    12001 agcatcctca ggcaataatt caggcatatc caaaccaaga cgtacaaaat cttcagctgc
    12061 atcggccaaa tcaagttgat agaaaacact tttttcatga ttaacggcca atgctttcca
    12121 gtttcctttt ctgaactctt cacgttgtgc atacaaacgc ttcagattgg cacctgccga
    12181 aatttcgtcc gcagaaaaac gttcggaacg taaccagata ttctttcctt cctccagttc
    12241 gggttcggac aacatccacc tcaacaccaa tcccaactct tctacagaat taaccatagg
    12301 gaatacggaa gatgcctgta aatcgtccgt acgtcctttc aaatctgtat atgacaaacc
    12361 gcgtttggac atccattcac caaaaggaat acccgtcagg gttgttttgg aatctctcaa
    12421 atctcctttg aaaacatcgt ccaggccgta tggacgggca acaaagccct tatcacccat
    12481 cggaaccaca tctacacaca ctccggcagg cacagccaac gaccagtcat tttccggaac
    12541 cccggtaata atatgtcgtg aagcaatctt ccactttggt ccgatatgac tgttctcgat
    12601 ccataaatca gcattctcgg cacaaagagg tatccgcact acagcatttt ggacaaacat
    12661 agccggattg ggctttactt tacggtgcat gatacgacgc tgatcgtaaa ccttattctg
    12721 tacggaaaga gttgaagaaa tcagttcttt actggtccca taatgataga actctcctcc
    12781 cggcaaaggc agaatagcaa cggatagcgt attgacctct tcgtcttcaa tacggggatg
    12841 agttcccaaa gctaatccaa aatcggaata aagatcataa tactttagtt cttcagagct
    12901 ttctttatga gaacgtttca tcaagatttc tacggcacgg tcactcaaaa gccatatacc
    12961 gatgtccatc aggaacaaat gggtcttcga taaagattcc aattctgcca acgaaggctt
    13021 ctgaagcata aagtcgagtt gttcgggatg tttgcgatcg gaagcaaaca cgccatgatg
    13081 ggtagccaga gacggatcta cccacagtcc ataacaaacc acatccgctt cgggaatact
    13141 ctgcaaaggt ttctccgaac gaatatagac atcaccactc gcaatcagtg tatggagttt
    13201 atccggagcc aaagacatga tttttcatat aggggaagtt gcagagaaag cagattttgt
    13261 cccagatgtt gccctctctc ccaccggaac acaggaaccg gagtgagaat ctttccagaa
    13321 ggtgcatagc cgggtaaacg acggctttgc ccacccgcat gaagaagaat tcttttttct
    13381 ttttcaagcc actctccaaa agtagcacca tctgaatatt cattataaca ttcttcaagc
    13441 aaccaggatg ttccaccacc ggaaccaagt ttcttaccta ccgggtcgga agtacaaaac
    13501 caatcggtac ggttcaccct ctccagttca tgaaaagact gaaccagatt gggcggta
//
