LOCUS       gnlProkkaPNKDKHOP_6    13885 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PNKDKHOP_6.
ACCESSION   gnlProkkaPNKDKHOP_6
VERSION     gnlProkkaPNKDKHOP_6
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:16:11
            Original ID  :: gnl|Prokka|PNKDKHOP_6
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 115517
            Orig. end    :: 129402
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13885
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13885
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13885
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2153..3163
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_86"
                     /sec_met_domain="PF04055 (E-value: 9.5e-18, bitscore: 57.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3182..4222
                     /locus_tag="ctg6_87"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             4227..5321
                     /locus_tag="ctg6_88"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5331..5858
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 186.2; E-value:
                     1.7e-56)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg6_89"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKRMCVWWRLPTSILHKRL
                     QKDVSVKIYITG"
     CDS             5864..6571
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 121.2; E-value:
                     8.9e-37)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg6_90"
                     /transl_table=11
                     /translation="MPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKEL
                     LAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFES
                     EREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPAI
                     IHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNISE
                     RTLYRKIKEYELD"
     CDS             6558..7085
                     /locus_tag="ctg6_91"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7091..7864
                     /locus_tag="ctg6_92"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7871..8266
                     /locus_tag="ctg6_93"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_94"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_95"
                     /sec_met_domain="PqqD_RRE (E-value: 2.3e-10, bitscore:
                     32.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 8.4e-17, bitscore: 54.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQYEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg6_96"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10691..11758)
                     /locus_tag="ctg6_97"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11832..13343)
                     /locus_tag="ctg6_98"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCHTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYST
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWQLVSE"
ORIGIN
        1 tacgctcatt tccagttgaa tggtttttca caggcggatg ccaagtcgtt ctcaaagcaa
       61 tatttgtcta cttactccaa ggctttgtcc gcacaacagg aagatattct tgcttcgtgg
      121 gtgctggcta aacaaccgcg ctgtttaagt gtattgctca acgagctggt ttcgttcggt
      181 cagtacgatg ctctcaatga atatatgagt ggatattgcc ggctcaatga ggttgggcaa
      241 ttctatgaca gtgtgctacg gcgtttgtcg gctgattatg gtttcgaaga gattggaaga
      301 acgcttctga tgctttcact tactttagaa ggatttaccg aagatgaagt gaagagcatg
      361 gcagacatta atcagatact ttggtcgcag ttgagagtgg aaatgagcag ctggctcact
      421 aacaaaggag ggcgatattg cattggtgac acacaaatgg tagaggcaat cgaacgctat
      481 ttcgctcaag atgacgaatg tatagatgat agtcgccatg aaattatttc cgctctgctg
      541 gatgaggaag agattctttc ccatccgttg acttttgccg attataacta tcgcatgaaa
      601 cagttctgct accatgattc gtatcgctat aaagtggaga ttacctatca atgctataag
      661 atgcaagaat gggatatatt gaaggattgg atttgtgatg tggagatttt cgagattctg
      721 tatcgcacga atcgttctct gttggaagat agctggaagg cgatcatgaa cgacaatcct
      781 gaagttacgc ctgaagtcta taccgaattg gattttgatg agatcgattc ttttttaatt
      841 cctgtcattg ctaatgatat ggctactttc ttgagcagtt ctttccatct aacgaaggcg
      901 gcagctgctg tgagtgagaa gagtatggaa ggtgctgcca tgccactcat tgccaagtcg
      961 gtattgaaga tgaatgaggg atgccggtat gcccgtaatg aagaatacga aacggcatgc
     1021 gactgttttc tgaaagcatt ggtgatgcag gaaaacatag taccgactcc ggaactggag
     1081 attgccaaca cctgccgaaa tctagctctg gcatattact acaatgagca atacaatgaa
     1141 gcggtgacct atctgaatag ggcgcttgat tatcatgcgg cttctgctga tgagaagagt
     1201 caggcagaag tcattgaact ttccgaatat ctggcttatt gtgattacta taaggatgag
     1261 gaagagaggg ctgccgagaa attccggaaa gtagctgaaa tgcacgagtc gttgaatggc
     1321 agactgtccg gtggagtggc taaatgtttg cgtatgcagg gtaaatgtct ttattatatc
     1381 aaacgatacg atgaagcatg gatgctgatg aatcaggcgt tggacattgc tatacagata
     1441 gacagcaaaa aacagatcgt cgcttgtcat aaacagttgt attatctatg cagggaattc
     1501 aaacggatga tgaatgaacg tggcgatgag caggcgtcta ctttattctt ccgtgagtct
     1561 cttctgcatg aaatgtattt cagcgaaaaa ccgcgtctgg cggaattgac tgtccgctac
     1621 gaggcattga gatgtgatat tatgcagcag tattacatga ataaagacta tgataacgtg
     1681 attcgtattg caacgtcttt ggattttcac gatgatgctg accctaatgc ttcctgtctg
     1741 gtatattatt acaaagcaca ggcttatgtg aagttggaga attatccaat ggcgaaagag
     1801 gctttcttca gagaacttga actgcgaaag aagtatttgg gatgggagga agaagatacg
     1861 attctggctt gtcagaactt aggggttttg cacagctttt gtaatgaacg ggaagaggcg
     1921 ctggcttgtt tccgtgaggc gtacggttat gaagtgaaaa agaatggcga ggattctgaa
     1981 atggcgcaaa agctacttca atatatcagc gtggttgaat cataacggag gcatacttcc
     2041 cttttttgtt aacttttaca ttcctgctat acggaaatcg actttatttc cttacatttg
     2101 cagatataaa ctatcaacag aaagaagaat gtctaaatat ccccttttag gaatgactct
     2161 tgtagagctt caatcattga caaaaagact gggtatgccc ggctttgctg ccaagcagat
     2221 tgcatcctgg ctttacgaaa agaaggtagc ctcgattgat gatatgacta atttgtcatt
     2281 gaaacaccgg gagttgctca agcagaacta tgaggtggga gcggaagctc cggtagatga
     2341 aatgcgctct gtagatggta cggtgaagta tctttataaa gtgggtgaga accattttgt
     2401 agagtcggtt tatataccgg atgatgaccg ggcaacgttg tgcgtgtcgt cacaagtagg
     2461 ttgcaagatg aactgtaagt tctgtatgac cggcaaacag gggtatacgg ctaacctgac
     2521 cgccagccag atcatgaacc agattcattc gctgccggaa cgggacaaac tgactaatgt
     2581 cgtaatgatg ggaatgggcg agccgctcga taacctggat gaggtattga aagcattgga
     2641 actactgacc gctacctacg gttacgcatg gagtccgaag cgtatcacgc tttctactgt
     2701 cgggctacgg aaaggattgc agcgttttat cgaagaaaat gactgccacc ttgccatcag
     2761 ccttcactct ccgctgaccg ttcagcgtgc tgaattaatg ccggcggaaa aggcgttttc
     2821 aatcaccgaa atggtggaac tgttaaaaaa ctatgatttt agtaaacaac gtcgactttc
     2881 gtttgaatat attgttttta aagggctcaa tgattcgcag gtctatgcca aagagttgct
     2941 gaaacttctt cgcgggctgg attgcagggt gaatctgatt cgttttcatg ccataccggg
     3001 ggtagacctc gagggggcgg atatggatac gatgacccgt tttcgtgatt atctgacatc
     3061 acacggactt ttcaccacta tccgttcatc caggggcgaa gatatttttg ccgcttgcgg
     3121 tatgctgtcg acagcgaaac aggagaaaaa taatgaaagt taatatataa aaccgaacat
     3181 catgaaaaag tactctttta ttttatgcat cgctttggta gcctttgtcg ttgcatcttg
     3241 tggtctgaaa ggaaatcaca cctctagtgg tcgtgcttac gagcttttgg ttgtagtaga
     3301 tcacggtgtt tgggatcgtg ctgccggaag ggctttacat gatgcgctcg atgctgatat
     3361 gcccggtttg ccgcagtcgg aaccttcttt ccggattatg tatacttcgc cgaaagatta
     3421 tgattctacg ctgaagttga tacgtaacat tattattgta gatatacagg atatatatac
     3481 gaaagcctcg ttcaaatatg cgaaggacgt gtatgccaat ccgcagatga tattgactat
     3541 ccaggctccg aacgaagaag agtttgagaa gtttgtggaa gagaacaaaa agacgattgt
     3601 cgacttcttt acccgtgcgg aaatgaaccg tcagattacg ttcctggaag ggaaacacag
     3661 taatttcatt tcgcagaaag tggacagttt gttcggatgc gacatttggg tggatgccga
     3721 actggctaat tcaaagaccg gggatgattt cttctgggct tctaccaaca ctggtactgc
     3781 cgaccgtaac tttgtgatgt actcttatcc gtacactgac aaggatacgt ttaccaaaga
     3841 atattttgtg cacaaacgtg actccgtgat gaaagccaat attcccggat tcaaggaggg
     3901 cgtttatatg tcgaccgata gtttgctgac cgatgtccgt ccgatcaatg tgcagaacag
     3961 ctacacaatg gaagcacgtg gcctgtggcg tatgaagggc gactttatgg gtggtccgta
     4021 tgtatctcat actcgtctgg acgagaaaaa ccaacgaatt attacagcag aaatatttgt
     4081 ttattcacct gataaaatga aacgcaacct ggtacgccag atggaagcat ctctgtatac
     4141 actgaaactt ccgaatgaag ttcagcagaa tcagattcca ttgggagaag catctaagga
     4201 agcggaacaa actaataaat aaaaacatgg aagataacaa gataaggata ggtatcaccc
     4261 aaggagatat taacggggtg ggctatgagg tgattcttaa gacattttcc gaccctacga
     4321 tgttggaact atgtactccg atcatttatg gctcaccgaa agtagcggct tatcatcgca
     4381 aagcgctgga tatacaggcc aattttagca ttgtcaactc tgctaccgaa gcggggtaca
     4441 accgtttgag tgtggtgaac tgtacggatg atgaagtgaa agtggaattt tccaaacccg
     4501 accccgaagc cggtaaagct gcgctggggg ctttggaacg tgccatcgaa gaatatcgcg
     4561 aagggttgat agacgttatc gtaacagctc cgatcaacaa acatacgatt cagtcggaag
     4621 agttctcctt ccccggacat acggaatata tcgaagaacg tctgggcaat ggtgataagt
     4681 cattgatgat tttgatgaag aatgacttcc gggtggcttt ggtgacgaca catatccctg
     4741 tcagagagat cgcgactacg attaccaaag aactgattca ggagaaactg atgatattcc
     4801 atcgttgtct gaaacaggat ttcggtatcg gtgctccgcg tattgcggtg ctctctctca
     4861 atcctcatgc cggagacggt ggtttgttgg gaatggaaga gcaggaagtg attatccctg
     4921 ccatgaaaga aatggaagag aaaggaatcc tttgctacgg tccttatgcg gccgacggct
     4981 ttatgggttc gggcaattat actcattttg acggtatcct ggcgatgtat cacgatcagg
     5041 ggctggctcc gttcaaggcc ttggctatgg aagacggggt gaactatacg gcaggactgc
     5101 cggtagtacg tacttctccg gctcatggaa cggcatacga tattgcaggt aagggagtgg
     5161 cttgtgaaga ttctttccgt caggcaatct atgttgccat cgacgtgttc cgtaatcgtc
     5221 agcgggaaaa agtggctcgt gccaatccgt tgcgtaaaca gtattacgag aaacgtgacg
     5281 atagtgataa actgaagctg gatacagtag acgaagatta aaaacgagtg atgacgaaag
     5341 cagagataca acaagtgaaa cagcgtttcg gtattattgg aaatactgaa gcattgtcgc
     5401 gcgccataga tgttgccatt caggtagctc ctaccgattt gtctgtgctg attaccggag
     5461 aaagtggagt cggaaaagaa agttttccgc agattattca tcaatatagc cggaggaagc
     5521 acggacagta tattgctgtc aactgtggcg ctattccgga aggtacgatt gattccgaac
     5581 tgttcggaca tgagaaaggt gcgtttaccg gtgcgattgg cgaacggaaa gggtactttg
     5641 gcgaagctga cggtggtact atttttcttg atgaagtagg ggagttgccg atgtctaccc
     5701 aggcacgttt gctccgtgta ctggagagtg gcgagtttat gaaagtaggt tcgtccaaag
     5761 tacaaaaacg gatgtgcgtg tggtggcggc taccaacgtc aatcttacac aagcgattgc
     5821 agaaggacgt ttccgtgaag atttatatta ccggttgaat acggtgccta tccaaatacc
     5881 gcctttgcgt gaacgtggtg acgatgtgct tttgttgttt cgtaagtttt ccgcagactt
     5941 tgcagagaaa taccggatgc ctgctattca gttgacggag gatgcgaaga aagagttgtt
     6001 ggcttacccg tggccaggaa acgtgcgcca gttgaagaac atcaccgagc aaatatctat
     6061 cattgaaact aatagggaga tctctgctgc tatcttgcag aattatcttc ctgcacaaaa
     6121 tacgcaacgt cttcccgcgc tgatgggaac gcgtgagagt aaaggctttg agagcgaacg
     6181 ggagattctt tattctgttc tgttcgatat gcgccaggaa gtggcggagc tgaagaagat
     6241 ggtgcacaac ctgatggcgg aacgtgccgg acaggtgggg caggtaggac aaatgggaac
     6301 ggtggttact actccggtag tgacggcgca tcaaccttcg gtacctgcta tcattcacac
     6361 catgcaacct acggtttgca aggatgatga tgacatacaa gacacggaag aatatgtaga
     6421 agaatctcct ttgtcactgg atgaagtgga gaaagaaatg atacgcaagg cacttgagag
     6481 gcatcatgga aagcggaaga gtgcggccaa ggacttgaat atttccgagc gtacacttta
     6541 tagaaaaata aaagaatatg aattggatta agaaaataat acgccctttg ttactgttcg
     6601 gcttgccgtt ggtagtcatt gcgtgcactg tttcctataa gtttaacgga tcgtctatca
     6661 attatgataa ggtaaagacc atttcgatag ccgacttccc gatcaagtcg gagtatgtat
     6721 atgctccgtt agcaaccaaa ttcaatgagg acctgaaaga tatcttcatc cggcagaccc
     6781 gtctgcaact gctcaagccg aatcagaatg cggacttgca gattgacgga gaaatcacag
     6841 gatacaatca gtacaaccag gcagtatctg ccgacggtta ctcttcggag acgaagttga
     6901 ctattaccgt caatgtacgt tttgtcaaca acaccaatca tgccgaagac tttgaacaac
     6961 agttttctgc gttccgtacc tacgactcta gccagttgct gactgccgta caggacggat
     7021 tgattgctga aatgtctaaa gagatcaccg accaaatttt taatgcaact gtagcaaact
     7081 ggtaatataa atgacttctg ttaactttca acaatggatt cagcatcccg agacgctgaa
     7141 tagggatact ttgtacgaac tgcgcaatct tcttgcgagg tatccgtatt ttcagtcact
     7201 tcgtctgctg tatctgaaga atctgtatat tctccatgat attagtttcg gtggagaact
     7261 gcggaaagca gttctttaca ttgcagacag acggcagttg ttccggttga ttgaaggtga
     7321 ccgctatgat gtgcaggcac ggaaaaaggg agtacctctc acggaggtgc tgaaagacga
     7381 accgtccgta gaccgcacat tagcattgat cgacgctttc ttgtctacag tacccgaaga
     7441 ggtgactgcc cgcaccagct tcgactattc gatggattac acctcttatc ttttggagga
     7501 gactccggcc acggaacagt cggccgaaga aacgcccaaa ctcaaaggct acgaactgat
     7561 tgacgacttt atagaaaaga gcgagagcga ctctcccctc tgcatgaaac ctttaagaga
     7621 agaaatgcca tcttcgccaa cctcttcgga cgaacttacc gaagaagaaa caatgaagga
     7681 agaagaggaa gatgacagct gttttacgga aactttggca aaaatctatg ttaaacagca
     7741 acgatattca aaagctcttg aaataattaa aaaattaagc ttgaaatatc caaaaaaaaa
     7801 tgcttacttt gcagaccaaa tcagattttt ggagaaattg attattaacg ctaattcaaa
     7861 ataactaaaa atgtacttat tattcgttat cttaatggtt attgcagcct tgttgatgtg
     7921 tttcatcgtg ctgattcaga actcaaaagg aggcggactt gcttctggtt tctcttcatc
     7981 taacgccatc atgggcgtgc gcaagactac agattttctg gaaaaagcaa catggggctt
     8041 agctatcttc atggtggtaa tgagcattgc tactgcttat gtagttcctc gctctgctgt
     8101 tgctaaagac gcagtgttgg aacaggcaca gaaagaacaa cagactaacc cgtataactt
     8161 acccgcaggt acggctgcgc cgcaaactga agctcctgct accaatgcac ctgctacaga
     8221 aactccggca ccggctactg aaactcctgc tcctgcagca gagtaattca ctccgttgtc
     8281 aggtaagact ttggggtaaa accattaatg ggaaggtgca gacggatgct gcatttcttt
     8341 gatatttaag tgcggattac gcagattaca cggattttca atcttccgcg tggtcagtgt
     8401 aatccgcact taactttttc ttgtaaaaac aatctctttt tgatagaaac aaacgagatt
     8461 taactacctt tgttggtcgt atgaagatta ttaactactt ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 gggtggttta atgtattcct gttgatgctg attttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggggcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tctttggatt caaaacacag
     8881 gtaaccctgg ccgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt aaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgacttct tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggaaccgga agaaccgttc
     9241 cgtatgaaag atattgtgta tatcattacg aataagggat tctggttgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtatcggtaa gggagctacg
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgttcgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactatcatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtacc
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttaaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactgggaa attcaatacc taaagtgaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 atatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggacccc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagtttactt
    10681 cctcgttttt ctatttccct tcttctctgt ccactttgag caatcctccc gtattcggat
    10741 caaaataaac tttgatggta gaattcttgt tgaacaaaac cggagccaga tattctatca
    10801 caccaaattg agtaatagga agctcacctt cgtaaagttt ctttttaccg tcggtcagtg
    10861 taaccatagc ttgtccgggg acgttgtagg cgattccatc caaatctttc ttcttcttac
    10921 catcttcctg tggcatcttg accgatttca ggtctttcag actgatataa aacggagttc
    10981 ctgccaaatc attgttggca actacaccta acttcttcga gaagcggaaa gcaacttcat
    11041 tgttgaattc cttgtcaggg gtaaggcgga cagtgaatgt tctctcttct ttgttgcagg
    11101 tgccggagaa catttgcgtc atggcttctt cctgtgcatt cagattgtcg agcataattt
    11161 taagctgtgc tccgtctgaa ggcatattgt cagcctgtcc gcgcaataag gcatttttgc
    11221 tttcgcggat gttatagatc tctttagcca ccagctcggc catcttggcg gtagagctgg
    11281 ccatcagaat ctcctcggtc aggaattcac gaggattcgc tttcttttgg aggactgcgg
    11341 gggcgggagc agcttttttg cctacactgc tattgctgta aggaacattg atcgttttca
    11401 caatgccatc ctctgtcagt tccatgagcg gtgctactgt cttatccttc aattttacga
    11461 aatacgtagt ttcgctgttg ggcacaccta cggatttcac ttttacgcta gccagttccc
    11521 agtactcttc agggtcggcg gagacgttgg tcagtcgcag gtaacgatca gcatatttgc
    11581 tgaattctcc cggagtatag ttgactttgt tggcttttat ttcaagttct atttgggttt
    11641 tgggaagact gtaaaccact ccatagtctt ttcctcgggt aacccctgtc agtacttcgg
    11701 tttgtgcata ggcggacgtt gtcattagta gtcctgctgc tataatcaac tttttcatat
    11761 tcggttcttt tttaactggt tttgaaaaca aagttaatga agttattgaa aaaagggtaa
    11821 gttcttaact tttattcgct tacaagttgc catgctgtcg gcagacaggt gataatatcg
    11881 cttgcgatca ttccgatcat tccttgcttc ttttgagcga catcgcccgc caatccgtga
    11941 atgtaagtgc cgattttagc ggcttcttcg gttgagtaac cttgggcaag cagtgccagg
    12001 attactccgg tcagtacgtc accgctacct ccggttgcca ttcccggatt tccggttggg
    12061 ttgaagaaac atttaccttc tggggtgata atggcggagt aggctccttt taaaataatg
    12121 tgaacatggg cggcacgagc caattcgcaa gccttcatca gacgttcgta agagtcctgg
    12181 catttgccgg tcagacgttc cagttctttc ggatgcgggg tgaggatgga acccttcggc
    12241 aggtgggtaa gtgcatgacg gtggttggcg aggatattaa gtgcgtcggc atccaccaca
    12301 acaggagtat ggcaatgttc cagttgctcc aataaagcag cttccgtttc ctcgtttcgt
    12361 cccagccctg ggccgatgcc gactgcttga tagtcgtccg tgtcggtagg tacggcaaaa
    12421 caggtttcgt tgatgtcggt ttctacgatt gcttcgggta tggaggtctg caagatgtcg
    12481 ttgttgcaca ttggcgcatg gacagtcagc aaccctactc ccgaacggag gcaggcgcgg
    12541 gcagcgagaa cagaggctcc tgccattcct tttgaaccgg caatcaatag tgcatggccg
    12601 aagttcccct tgtgggcaaa ctgtttgcgt ggcttgatga gtgaacggat ttgctctatt
    12661 tccaacattt cgtagttcgt ttccatctct tcaataccgt cttcgcttaa ttggatgtcc
    12721 agcacttccc attctccgac aaattccgtg ttctctgcga aaagaaaggc gagcttcggc
    12781 agttgcagac tgaaagttac gtcggcacgg ataatattag cttttacgtt gaatgtgttt
    12841 tcttctccca tcagtccgga aggaatgtcg atggctacta ccatagcagg ggaggaattg
    12901 atgtatttca ctacggcagc gaatccgccg cttaacggtt tgttcaggcc tgaaccgaat
    12961 aatccgtcga ttaccagatg gtcgggcgtc aggacgggag gtacgaattg ggtactgatt
    13021 tcgtggaatt ttacttcttc catcatttct accagttctt tattggtttg gcagtcgggt
    13081 gaaagttctc ctttcgtgtt gaagagaaat acctcgattt tatatccttt ttcagccatc
    13141 atgcgggcta cggcgagagc gtctccgcca ttattccccg gtccggcaaa gatagtgacc
    13201 ggcgtttccg tattccatct gtctgtgatg gcttttgtta atacggttgc tgcacgttcc
    13261 atcagatcga ttgatgcaat aggttcgttc tcaatggtat aagcgtccaa tttcttgata
    13321 ctgctgcttg gaaatatttt cattgcgatg ttcttttagt tttcggatta caaatgtaca
    13381 tgattcttct gacttttccc gtttgttgtg ggaagaaaac cataattgca acttttaatt
    13441 catcattagt tctatctttg ggtcagagaa atatctgctt ttgaactatt aagtgttaga
    13501 ataactccgc caaaaaataa ttcaatgcag caccattatg aacttacttt tatttctcct
    13561 gaaaaagatt tggttcttaa tcaaattccg tgctagtaaa gctcattgaa aggccgatgg
    13621 ataaagggat atcggcatat tagaaatagc aaataaatta tccaaactat atgcatctta
    13681 aagtactccg gaatagccat gaataaggta attgaacata aataagtagc acggaatttg
    13741 acgaagaacc aaagatttcg gttcttcgtc aaatttggtg gtaatctctt ttttatttca
    13801 actgtcttct tctttcttaa tcctattaaa agttgtagat atgtttgctt tttagtaact
    13861 ttaaagacac cacatcatta agagt
//
