LOCUS       c00004_gnlPro..        14639 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FDHCKDIO_4.
ACCESSION   c00004_gnlPro..
VERSION     c00004_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 17:32:10
            Original ID  :: gnl|Prokka|FDHCKDIO_4
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14639
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14639
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1680:4639]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1681..4639
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..14639
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14639
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             3..116
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MSRKTEYVHNPCFLSANILKILGVFAENQNKLYNVYH"
     CDS             complement(137..1069)
                     /gene_functions="resistance (resist) CfxA (Score: 668.2;
                     E-value: 9.6e-204)"
                     /gene_kind="resistance"
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="LCIALVCIIVLVFLLFSKSTSNNSTNPPLTDVLTDSISRIVSACP
                     GEIGVAIIINNTDTVKVNDKSVYPMMSVFKVHQALALCNDFDNKGISLDTLVKIDRNRL
                     DSKTWSPMMKDYSELVISLTVRDLLRYTIAQSDNNASNLMFKDMVNVAQTDSFIATLIP
                     RSSFQIAYTEEEMSADHDRAYFNYTSPLGAAMLMNRLFTESIVSGEKQSFIKNTLKECV
                     TGTDRIVAPLLDKERVSIAHKTGSGYVNENGILAAHNDVAYICLPNNVCYTLAIFVKDF
                     KGNESQASQYVAHISEVVYSLLIQNSAIP"
     CDS             1132..1260
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MTDPDLLFTAKIRNLTENELVVFFVCSVFYQIIFRANMIRLK"
     CDS             1681..3909
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_4"
                     /sec_met_domain="Gly_radical (E-value: 1.3e-45, bitscore:
                     148.8, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1166.2, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFKDGLWSKEINVRDFVSNNITPYEGDASFLQGPTERTKA
                     VWNHCLKALEEERNNNGIRALDYTTVSTITSHPAGYIDKENELIVGLQTDQVLKRAIKP
                     FGGINVVMKACRENGVEVDDRVKDIFTHYRKTHNDGVFDVYTDEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGLDRLIEAKKEDLHNLTGPMTEACIRLREEVAEQIKALKEIK
                     VLGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSQ
                     GTITETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESIGGRFNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNMTVLWSPELPEGFKAFCAQVSIDTSSVQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKDIPVLTGETL
                     KFEEVMANYKKVLIQIARVYNEAMNIIHYMHDKYYYEKAQMAFVDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAHVKARRNDIGLTEGFDIEGAFPCFGNDDDRVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGIAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATQEDRIDNLVTMMDGYFTKGAHHLNVNVLN
                     REMLQDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             3914..4639
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_5"
                     /sec_met_domain="Radical_SAM (E-value: 1.8e-29, bitscore:
                     97.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIEAKGG
                     TATDPEEIVRMAVSQKAFFGKKGGITFSGGEPTFQAKSLIPLFKRLKEAGIHICLDTNG
                     GLWNNDVEELLELTDLVLLDIKEFNPEHHQSLTGRSNEQTLKTAAWLETNHKPFWLRYV
                     LVPGYSDFEDDIRQLGEHLGTYQMIQRVEILPYHTLGVHKYEAMNKEYMLKGVKENTPE
                     QIEKAEKLFRQYFRTVQVN"
     CDS             complement(4872..6131)
                     /locus_tag="ctg4_6"
                     /transl_table=11
                     /translation="MKEDEKWIKAFKDKLEDYSEPMPASGWERLERELMPVTEKRIYPY
                     RRWAVAAAAVVLVLTTAVSLYFLNSPVADEIRYATTPSLAVNPDVLPEPALPDVQVAVS
                     EPVKPVGTTSINPVSGYLAKNTDPVIVPEVSSLAEKRPEAVTEEKRAEPQQEATAAIEK
                     KESATAQPPKRKEARRPSGKDKYQLPIGDSSAKRGGKWSMGVGIGNGGGLPTNGSENFA
                     PRPMTNRVDLMTIMNGAVSIPADQEVIFEEGVPYLKSNTTAVVDYEHHQPVSFGLSVRK
                     SLPKGFSVETGLTYTLLSSDIKRQGDTKMQSQKLHYIGIPVRGNWNFLEKKYFTLYVSA
                     GGMVEKCVYGKLADDKVNVKPLQFSVAGAVGAQFNATDHVGLYVEPGVSYFFDDGSKVQ
                     TIRKERPCNFNLQAGLRFTY"
     CDS             complement(6186..6734)
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MNELELSERCRQGDNRARKELYEQYAGRMLGVCLRYAGDRDMAQD
                     LVHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQFLRKNDVMNQTTALDEVPETY
                     EEPDASAVEAIPQKVLMQFINELPAGYRTVFNLYTFEDKSHKEIAQMLGINEKSSASQL
                     FRAKSVLAKKVKEWLVTNG"
     CDS             6922..7674
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MKKFNLITFAVILMLLPILQSCLDDANNDEWVTCPPGGILAIGTM
                     KIPNADTPRDFFIALDNGDNVLPADTADIRNRKYTVAEGQRVFVGYLQMGEEKPGYENG
                     KIFTIEDILTKEIIPLTEATADSIGDDRINVTAHALTKDYLTIEYQYLGSMNENKKHML
                     NLVQNEITGPIKDDGYIYLEFRHNAFNDSPNQLGSSLVSFKLDSIAEQLATAKGIKLRV
                     NTIYDNIQYVTIDINEDKNLKIKSFHSQ"
     CDS             complement(7779..8705)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     -3.4; E-value: 35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_9"
                     /sec_met_domain="LysR_substrate (E-value: 5.4e-46,
                     bitscore: 151.1, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.5e-17, bitscore: 57.2,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQQLEYILAVDQFRHFAKAAEYCRVTQPTLSAMIQKLEDELGV
                     KLFDRSMTPVCPTAIGKKVLEQARKILSEVICVKEIISEEQHSLSGTFRLAVLPTIAPY
                     LLPRFFPQLMEKYPDLDIRVMEMKTPDIRKALLTGEADAAIIASMLDDAALTEETLFYE
                     QFLGYVSKKEPLFKHDVIRTSDVTGERLWLLDEGHCFRDQLVRFCQMEAVKISQMAYRL
                     GSMETFMHMVESGKGITFIPELAVMQLSEEQKELVRPFAIPRPTRQIVLVTRKDFIRTS
                     LLQVLKEEIQAAVPKEMLTLQAVQCLV"
     CDS             8847..9320
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MKTLNYTHLEEKGANTIVLSLQQLLADFQIHYANLRGFHWNIKGH
                     GFFVLHSKFEDLYNGAAEKVDEIAERILMLGGTPANKYSDYLKMAQIKEVDGVNKADDA
                     LNHILETYGHLIAEERKILSLASSHNDEVTVAMMSDYLKEQEKMVWMLTAYNG"
     CDS             complement(9424..10422)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_130"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_11"
                     /sec_met_domain="Glyco_hydro_130 (E-value: 8.5e-69,
                     bitscore: 226.4, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEIKIAGAALPAMPWEERPAGCKDVVWRCSANPIIPRDLLPTSN
                     SIFNSAVVPFKDGYAGVFRCDDTNRRMRLHVGFSKDAVHWDINEEPLKFQCDDAEVGTW
                     VYGYDPRVCFIEDRYYVTWCNGYHGPTIGVAYTYDFVTFHQLENAFIPFNRNGVLFPRK
                     INGRFAMLSRPSDNGHTPFGDIFYSESPDMEFWGRHRHVMSPAPFEDSAWQCTKIGAGP
                     IPIETSEGWLLIYHGVLASCNGFVYSFGSALLDIDQPWKVKFRSGPYLISPQKDYECMG
                     DVPNVCFPCAALHDSETGRIAIYYGCADTVTGLAFGYIPEIIEFTKRTSII"
     CDS             complement(10477..11745)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_12"
                     /sec_met_domain="MFS_1 (E-value: 1.5e-11, bitscore: 38.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKPISPVCWVPTVYFAMGLPFVALSMVSVLMFSDMEVSNAQIA
                     FWTSLIMLPWTLKPLWSPFLEMFKTKKYFVVATEIITGLAFALVALSLPLPDFFRYAIA
                     LMGIIALSGATHDIAGDGVYLTELTATQQAKYIGWQGAFYNLAKILANGGLVWLAGMLK
                     DEFGVVHAWMIVMLMCAGIMILIGLYHIRILPSGGGASGEVNTMSDALNMLWEVIRSFF
                     QKKHIAFYIVFIILYRFAEGYAIKIVPLFLKASVADGGLGLSTQDIGLVYGTFGAGAFI
                     LGSLLAGYYISAFGLRKTLFSLCCAFNIPFLVYFLLALYQPSDLWIIAMAIVSEYLGYG
                     FGFVGLMLFMMQQVAPGKHQMAHYAFATGIMNLGVMLPGMMSGYLSDWLGYRDFFIWVL
                     IATIPAFIVTWLVPFTYPDGKKK"
     CDS             complement(11995..13008)
                     /locus_tag="ctg4_13"
                     /transl_table=11
                     /translation="MNRHLNFVTLICLITGFVSLASCSNDDDEMDKYQKIYIRTGVAPG
                     AEMGAAVVVDCVSNSSTADRSDFEIQLCAVQLVTRDVTAALGVDTLKVDTYNSANKTKC
                     KLLPQDNYTIETSEVVLKTGQTVADSSFQVVLKNIEKLTNPDGYVLPVALKGVTGMDEQ
                     AVSTSMKTVYIRIYTSVLYTSYTKPGNWSAVDRSAWSVSCSNVYADDDAKYGAHLAIDG
                     EINTTWFTWGVANAGECWWNTLLDRPVTLTGFSVTKQSAYGSGYNLRSAEIKVRKEGET
                     EWVTYPRVLTFRNFKGADPQYAAIEPPIPNVKEFRINCLTPDNYTGFAEINLYVKQ"
     CDS             complement(13031..14167)
                     /locus_tag="ctg4_14"
                     /transl_table=11
                     /translation="MKRITIKQYLLACFVLPMILAGCNDADYQVIDNAIYLNEASENGS
                     AKVTVDPENVTTTTLTVRVGQPVTENVTAVLTVDPSILKEYNEANETSYEVLPEQYFTY
                     DKEIKIAAGDVSAIPSEFRVKPYSNENGELYAIPVSLTEIQGPVSTIGLSSKFIILLDK
                     PLIQSVPFMNTTNAVKPAKDELWGVTTNEWSLEAWVQMDGFDINNQAIFNSGSSDHEVY
                     IRFGDAMIPYNSLQVKTLGSQVNTVTLFEKNKWYHLAFVYNSSGLLSIYINGVLDVTLQ
                     TKGGPVRFDKMNMVSSGSYFRNNCQMAQVRLWKSAISQTQIQSNMYFAVKPADPNLIGY
                     WKMDEGKGNAFADCTGHGYDLVAGGTLVWKEHVRFDKQ"
ORIGIN
        1 aaatgagccg taaaactgaa tatgttcata atccctgctt tttgagcgct aatatactaa
       61 aaatattagg tgtgtttgcg gagaatcaga ataaattata taatgtttac cattgaagct
      121 tcaaagtaaa cgcaacttaa ggaattgccg aattttgtat taataaagaa tatacgacct
      181 ctgatatatg cgcaacatat tgtgatgctt gtgattcatt acccttgaaa tccttaacaa
      241 atatcgctaa agtatagcag acattattag gcaggcatat ataggcaaca tcattgtgag
      301 ctgcaagaat accattttca ttgacataac cagaacccgt cttatgtgca atagaaaccc
      361 tttctttatc aagaagcgga gcgactattc tatctgtacc tgtcacacat tcttttaatg
      421 tattcttaat gaaactttgc ttctcaccac tgacaatact ttcggtaaac aaacggttca
      481 tcaacattgc ggcaccaaga ggagatgtat aattaaagta agccctatcg tggtcagccg
      541 acatttcctc ttctgtataa gctatctgaa aacttgaacg aggaataagt gtggctataa
      601 aactgtcagt ttgagcaaca ttgaccatat ctttaaacat cagattgctt gcattattat
      661 cactttgagc aatagtataa cgaagtaaat ctctcacggt taatgatata accaactcgg
      721 aataatcttt catcatagga ctccaagtct ttgaatcaag tctattccta tctatcttta
      781 ctaaggtatc aagtgaaatc cctttgttat caaaatcatt gcaaagagct aatgcctgat
      841 gaaccttaaa tacactcatc ataggatata cactcttatc attaacttta actgtatctg
      901 tgttattaat aataattgcc actccaattt caccaggaca agctgatact atccgagaaa
      961 tgctatcagt caaaacatct gtcaaaggtg gatttgtact attattagaa gttgatttag
     1021 agaacaataa aaaaactaaa actatgatac aaactaaagc tatacacaaa attacaaggc
     1081 gttttcttct actttttttc atactacgat ttttaaacat tatatattat catgacagac
     1141 cctgatttat tatttactgc aaagatacga aatcttacgg aaaatgaatt ggttgttttt
     1201 ttcgtttgtt ctgtttttta tcaaattatt ttccgagcga atatgattcg tcttaaataa
     1261 aataaaaaca cccaccttta cattcttggg tgttaaaatt gggtgtttgt tttataattt
     1321 gctgattttc agcgtttatt gcggagagac agggattcga accccgggta cctcgcagta
     1381 caacggtttt caagaccgcc gcaatcgacc actctgccac ctctccagaa ctacggttaa
     1441 gtagtgcttt tctcttaaag cgctgcaaag gtacgaatca ttttttaact tgcaaattat
     1501 tccataaaaa aatattagaa aagtatattt ggaagtaata accgccctct ggcttctccc
     1561 cataaatagg tatttttatg ctattcaaca taaaatagga cccttttata tacctaaacc
     1621 gaaaaaaggt tgtaaatttg cgcgctctaa aggataacta accactaact gattaatttt
     1681 atggaactga ataagacctt taaagatgga ctttggagca aagaaatcaa tgtaagggat
     1741 ttcgttagta acaacatcac tccttatgaa ggggatgctt ctttcctgca aggacctacc
     1801 gaacgcacca aagctgtctg gaatcactgt ctcaaagctc tcgaagaaga gagaaacaat
     1861 aatggtattc gtgcactcga ctacacaact gtatctacta taacctctca ccctgccggc
     1921 tacatcgata aagagaacga actgatcgtc ggactacaga ccgatcaggt gttaaaacgt
     1981 gccatcaaac cgtttggcgg aatcaatgtg gttatgaaag cttgccgtga aaacggagtg
     2041 gaagtagatg acagagttaa ggatatcttc actcactatc gcaagactca taatgatggg
     2101 gtattcgatg tgtataccga tgaaattcgt tcgttccgtt cattgggatt ccttaccgga
     2161 cttcccgaca actatgcacg cggacgtatc atcggtgatt atcgccgcct ggctctctat
     2221 ggtcttgacc gtctgataga agctaaaaaa gaagatctgc ataatctgac aggtcctatg
     2281 actgaagcct gcattcgtct tcgtgaagaa gtagccgagc aaatcaaggc cctgaaagag
     2341 attaaagtat tgggcgaata ttatggtttg gatctgagcc gaccggcata taccgcacag
     2401 gaagctgtac aatgggtgta tatggcttat ctggctgccg taaaagagca ggatggtgct
     2461 gccatgtcac tgggtaatgt atcttcattc ctcgacatct atcttgaata tgaattaagc
     2521 cagggtacga taaccgaaac attcgctcag gaactgatcg accaattcgt tatcaaactc
     2581 cgtatggtac gccacttgcg tatgcagtcg tacaacgata tttttgcggg tgatcccaca
     2641 tgggtgaccg aatctatcgg tggacgtttc aatgacggac gtaccaaagt tactaaaact
     2701 tctttccgct tcttgcagac actttataac ttaggcccgt caccggaacc taacatgact
     2761 gtactatgga gccctgagtt acccgaaggt ttcaaagcat tctgtgcaca agtatctatc
     2821 gacacttctt ccgtacaata cgaaaacgac gacctaatgc gtgaagtccg tcaatcggat
     2881 gactacggaa tcgcttgttg tgtttcatat caggaaatcg gaaagcagat tcagttcttc
     2941 ggcgcacgtg ccaaccttgc caaagccctg ctactggcta tcaacggagg acgttgcgaa
     3001 aatacaggta cagttatggt aaaagacatc cctgtattga ccggtgaaac actgaagttc
     3061 gaagaagtaa tggccaacta taagaaagta ttgatacaaa ttgcacgtgt atacaacgaa
     3121 gcaatgaata tcatacatta catgcacgat aagtattact acgaaaaggc gcagatggct
     3181 ttcgtggata ctgatccccg cattaacctc gcttatggtg tagccggact ttcaatcgcc
     3241 atcgattcac tgtccgccat caaatatgca catgtgaaag cccgtcgcaa cgacatcgga
     3301 ctgacggagg gattcgatat cgaaggtgct ttcccttgtt tcggtaatga cgatgaccgt
     3361 gtagaccacc tgggtgtaga cctggtatat ttctttagcg aagaattaaa gaaactcccc
     3421 gtatataaga atgcccgtcc taccctctcg ctgctgacta tcacttcgaa cgtaatgtat
     3481 ggcaagaaga ccggtgccac tcctgacgga cgcgccaaag gcattgcctt tgctcccggt
     3541 gccaacccca tgcacggacg tgataaaaat ggtgcaatcg cctcactgag ttctgtagcc
     3601 aagttgcgtt atcgcgactc acaggatggt atcagcaata cattctcgat cgttcccaaa
     3661 tcattgggag caacacaaga ggaccgtatc gacaatctgg tgaccatgat ggacggatat
     3721 tttacaaaag gcgcacacca cctgaacgta aacgtgctga accgggaaat gttgcaggat
     3781 gcgatggaac atcccgaaaa gtatccgcaa ctgactatcc gtgtctcagg atatgccgtt
     3841 aatttcgtga aattgagccg cgaacatcag ttggaagtaa tcagccgcag tttccacgaa
     3901 agaatgtaat tgaatgataa acgtacactc atacgagtca atgggaacat tcgacgggcc
     3961 gggtctccgg ctcgtcgttt tccttcaagg gtgtaacttc cgttgcctct attgtgccaa
     4021 tccggacaca attgaagcca aaggagggac agcaaccgac cctgaggaaa tagttcgcat
     4081 ggccgtcagt cagaaagctt tcttcggtaa aaagggaggt atcacctttt ccggtggaga
     4141 gcctactttt caagcaaaat cgcttatccc actttttaaa agactaaagg aagcaggaat
     4201 ccatatttgc cttgatacca atggcgggct atggaacaat gatgtagagg aactattgga
     4261 attgactgat ctggttttat tagatatcaa agaatttaat ccggaacatc atcagtcttt
     4321 aaccggaaga agcaacgagc agaccctgaa aaccgcagcc tggcttgaaa ccaatcataa
     4381 accattctgg ttgcgatacg tattagtgcc cggctacagt gacttcgaag acgatatccg
     4441 gcagctggga gagcatcttg gaacgtacca gatgattcag cgtgtagaaa tattgcctta
     4501 ccacaccttg ggtgttcaca aatatgaagc aatgaacaaa gaatatatgc tgaaaggagt
     4561 gaaagagaat actccggagc agatagaaaa ggctgaaaaa ctattcaggc aatacttccg
     4621 gaccgtacaa gtgaattgac ttatataagt gtcgaaattc gtattcgcca cagattacac
     4681 gaatttacac agataaagat tcattggcaa tcaacagatt aagttcattc tgcggtgaat
     4741 tatgacgact gcacttattt ataattttgt aagtcacgat ataaaagtct ccctgttctt
     4801 gccttaattc attacaatac aaggcaagaa cagggagata atgtaaccgg catatttttt
     4861 gccatcctac tttaataagt gaatcgcaat cctgcctgca agttaaagtt acaaggcctt
     4921 tcttttcgga tggtttgtac tttggagcca tcatcaaaga aatacgaaac tcccggttcc
     4981 acatataggc cgacatgatc tgtcgcattg aactgcgctc ccacggcacc ggctacagaa
     5041 aattgcaaag gcttcacatt caccttatca tccgccaact ttccataaac acacttttca
     5101 accattcctc cggcagatac atagagtgta aaatatttct tttccagaaa attccagttt
     5161 ccacgtacag gaatacctat ataatgcaat ttctgactct gcatcttggt atccccctgc
     5221 cgtttgatgt cagaagacaa caacgtataa gtcaatcccg tctctacaga gaaacctttg
     5281 ggaagagact tacgtacaga cagtccgaag ctaaccggct gatgatgttc ataatccacc
     5341 acggcagttg tattggactt caggtaaggg actccttctt caaatataac ttcctgatcg
     5401 gcaggaatac tcacagctcc attcatgatc gtcatcaagt cgaccctgtt agtcatcgga
     5461 cggggcgcaa aattttcgga accatttgtc ggaagtccac ctccattacc gatacccact
     5521 cccatcgacc atttaccacc acgtttagca gaagagtctc cgataggcaa ctgatacttg
     5581 tctttaccgg acggtcgccg cgcttctttc ctctttggag gctgcgccgt cgcactttct
     5641 tttttctcga ttgcagcagt tgcttcctgt tgcggctcag ctctcttttc ctccgtcact
     5701 gcctccggtc gcttctctgc cagggaggat acctccggaa caatcaccgg atcagtattt
     5761 tttgccaaat agcccgaaac agggttgatg ctcgtcgttc ctaccggctt aacgggttcg
     5821 gatacagcta cctgtacatc cggcaaggca ggttccggca atacatccgg gttgacagcc
     5881 agtgaaggag tcgttgcata acggatttca tcagctaccg gactattcag aaaatacaaa
     5941 ctgacagcag tcgttagcac caataccaca gctgccgcag caaccgccca ccggcgatac
     6001 ggatatattc gtttttcggt tacaggcatc agttcccttt ccagtcgttc ccaaccggaa
     6061 gcaggcatcg gctccgaata atcttcgagc ttatccttga atgctttaat ccatttttcg
     6121 tcttctttca tcattctatt tcatttttga aatccaaggt tcacctcagt atctgtaaat
     6181 acatgtcaac cattggtcac caaccattct ttcactttct ttgccaatac actttttgcg
     6241 cgaaaaagct gtgaggcaga agatttttca ttaatcccca acatctgtgc gatttccttg
     6301 tgcgacttat cttcaaaggt atataaattg aatacggtac gatatccggc ggggagttca
     6361 ttaataaatt gcatcagcac tttctgtggt attgcttcaa cagccgaagc atccggttct
     6421 tcatacgttt cgggaacttc atccagtgcc gtggtctggt tcatcacgtc gttctttctt
     6481 aagaactgta aagccgtatt caccattaca cgctccatcc atgctctcag agagccttca
     6541 ccccgccagg taaacttgtc gaaggagtcg aaaatcttca ggaaaccgtc gtgtaccaag
     6601 tcttgtgcca tgtccctgtc tccggcataa cgaagacaga caccaagcat gcgccctgcg
     6661 tactgctcat aaagttcttt gcgggcacga ttatctccct gcctgcaacg ttccgacagc
     6721 tctaattcat tcattctcct aaacacgtgt ttaccttata aatgcagcaa agatagaaat
     6781 actgcacaga gagaacaact cttttatcac ttttgtttct ttaacatttt aggatgcaat
     6841 atatcatcac ttcctgcatt ttctcaatac aataaagaat aaatctcaat ggataaatag
     6901 gataaaacca acaagaaact tatgaagaaa tttaatttaa taacttttgc cgtcatcctg
     6961 atgttattgc ccattttaca gtcatgtctg gacgatgcca acaacgacga gtgggtcact
     7021 tgtcctccgg gtggaatatt agccatcggc acaatgaaga ttcccaatgc ggacactcca
     7081 agggactttt tcattgcgtt ggacaatgga gacaatgtac ttccggcaga tacggccgat
     7141 atacgcaaca ggaaatacac tgttgcagaa ggtcaaagag tcttcgttgg ctatctgcag
     7201 atgggagaag agaaacccgg atatgagaac ggtaaaatat tcacgataga agatatattg
     7261 acgaaagaga tcattccact gacggaagct acagcagaca gcattggaga cgaccgtatc
     7321 aacgtcacag cgcatgcact tacgaaagat tatctgacca tcgaatatca atatctgggc
     7381 agcatgaatg aaaataaaaa acacatgctg aacttggtac aaaacgaaat aacaggtccc
     7441 ataaaagatg acggatatat ctatctggag ttccggcata atgcctttaa tgactccccc
     7501 aatcaattgg gttcgagcct tgtttctttc aagctggata gtatagccga gcaattggcg
     7561 acagccaaag gaataaaact ccgtgtgaac accatttatg acaatataca gtatgtcaca
     7621 atagatatca acgaagacaa aaacttaaaa ataaaatcat ttcattctca ataaaacaac
     7681 aagaaacacc tacacaatca ggcaaaacga gtaataattc tgatacataa aagaaataag
     7741 gcggcgatgt ttgtgaaaat atcgccgtcg tttttatatt ataccagaca ctgaacggcc
     7801 tgcagggtaa gcatctcctt gggaaccgcc gcctgaatct cctctttcaa aacctgcagc
     7861 agactggtgc ggatgaagtc tttccgggtc accaggacaa tctgacgggt aggccgcggg
     7921 atagcaaacg gacggaccag ttctttctgc tcttcgctca attgcatcac tgccagttca
     7981 ggaataaacg taatcccctt accactctcc accatatgca taaaggtttc catactaccc
     8041 agccgatacg ccatttggct gatcttaacc gcttccatct gacaaaaacg aaccaactga
     8101 tcgcggaagc aatgcccttc gtcaagaagc caaagccgtt cccctgtcac atcggacgta
     8161 cgaatcacat cgtgcttgaa caacggttcc ttctttgaga catagcccag gaattgctcg
     8221 tagaataagg tctcttccgt taatgcggca tcatccagca tgctggcaat gatagcagca
     8281 tccgcttcac cggtcagcag agccttgcga atgtcgggcg tcttcatctc catcacccgt
     8341 atatcaagat ccgggtattt ctccatcagt tgcggaaaga aacggggcag aagataaggt
     8401 gcaatcgtcg gtaacactgc caatcggaat gtacccgaca gggagtgctg ttcttcgctg
     8461 atgatctcct tgacacagat aacttccgaa agaatcttac gggcctgttc cagcactttc
     8521 ttaccaatgg cagtagggca aaccggtgtc atgctacggt cgaacagttt cacccccaat
     8581 tcgtcttcca gcttttggat cattgcactc aaagtaggtt gcgtcacccg gcaatactcg
     8641 gcagctttag caaaatgccg gaactggtcc acagccagaa tatattccaa ttgttgtata
     8701 gtcatcgttc tctgatttat taaagatata gaatctatca atgcaaagat agaaattttc
     8761 agtttgacac gaatcatttt gtgccgtatc tttgttccag ataaaaagaa gaaatatagt
     8821 attaactcaa aaaaaacaat atcattatga agactttaaa ttatacacat ttggaagaaa
     8881 aaggagctaa caccatcgta ctgtcattac agcaactgct tgccgatttt cagattcatt
     8941 atgcaaacct gagaggattt cactggaaca tcaaaggaca cggtttcttc gtactgcaca
     9001 gcaagtttga agatttatat aatggagccg ccgaaaaggt ggacgaaata gccgaacgta
     9061 tactgatgct gggaggaact cccgccaata aatacagtga ctatctgaag atggcgcaga
     9121 tcaaggaagt ggacggagtg aataaggccg acgacgctct gaatcatatt ctcgaaactt
     9181 acgggcatct gattgcggaa gaacgtaaaa tcctgtctct cgcctcttca cacaacgacg
     9241 aagtaacagt ggccatgatg agcgactacc tgaaagaaca ggaaaagatg gtttggatgc
     9301 tgactgcata caacggataa cagccgaaag ggtgtagcca tctgaccgaa aaggtgtagc
     9361 catacaagca aaagggtgta gccatcccgg cgggatagct acaccctttc tgttttattc
     9421 gattcagatg atacttgtac gtttggtaaa ttcaataatc tccggaatgt atccgaatgc
     9481 gagcccggtc actgtatccg cacacccata atagatggca atccgtccgg tctccgaatc
     9541 atgaagcgcc gcgcatggga aacagacatt aggcacatca cccatacatt cgtaatcctt
     9601 ctgaggtgaa atcagataag gccccgaacg gaattttact ttccagggct gatcgatgtc
     9661 aagcagtgcc gaaccaaaac tatacacaaa accgttgcag gaagccaata caccatgata
     9721 gatcagtaac cagccttccg aggtttcaat cgggataggc cctgcaccga tcttggtaca
     9781 ctgccaggca ctgtcttcga acggagccgg cgacataaca tgacgatgac gtccccaaaa
     9841 ctccatatcg ggagactcgc tatagaaaat atctccaaaa ggagtatgcc cattatcact
     9901 cgggcgactc aacatcgcaa aacgaccgtt tatcttacga gggaacaaga ctccattccg
     9961 attgaaagga ataaaggcat tctccaactg gtgaaaagta acaaaatcat aggtgtaggc
    10021 cacaccgata gtaggaccat gatagccatt acaccaggtc acatagtagc ggtcttcgat
    10081 aaagcaaacc cgtgggtcat atccatagac ccaggttcca acctcagcat catcacattg
    10141 aaactttaac ggttcttcgt tgatatccca atgaacagca tccttgctga atcccacatg
    10201 caaacgcatg cgacgattag tatcatcaca acggaacacc cctgcatagc catccttaaa
    10261 cggaactacg gcactgttga atatactgtt tgaagtaggg agcaagtcgc gcggaataat
    10321 cggattggcc gaacaacgcc acactacatc tttacatcct gccggacgtt cttcccaagg
    10381 catagccggc aaagcagcac ctgcaatttt aatttcttcc atgattcgat taaattaata
    10441 ttatgtatat atcttgttta tattgaaaat ctctttttat ttcttctttc cgtccggata
    10501 tgtgaaaggt accagccaag tcacgataaa agccggtatg gtagcgataa gtacccagat
    10561 aaagaaatcg cgataaccca gccaatcgct caggtatccg ctcatcattc cgggaagcat
    10621 cacccccaga ttcataatac cggtagcaaa agcataatgt gccatctgat gtttgccggg
    10681 agccacttgc tgcatcataa agagcatcaa tccgacaaaa ccaaacccgt aacccaagta
    10741 ttcagacaca atggccatag caataatcca tagatcggaa ggctggtaaa gggctaacag
    10801 gaaatatacc aagaacggaa tattaaaagc gcaacataaa gaaaacaaag tcttccgaag
    10861 tccgaaagcc gaaatgtaat aaccggccaa aagcgaaccg agaataaaag ctcccgctcc
    10921 gaacgtacca tataccagtc cgatatcctg agtgctgagt cccaatccac catccgcaac
    10981 cgacgctttc aggaacaacg gtacaatctt gatggcatat ccttcggcaa accggtacaa
    11041 aatgataaag acaatgtaga aagcaatatg ttttttttgg aaaaaagagc ggatgacttc
    11101 ccaaagcata ttcaatgcgt cactcatcgt attcacttca ccggaagctc ctcctcccga
    11161 aggcaaaatc cggatgtggt aaagaccgat cagaatcata atacccgcac acatcaacat
    11221 gacaatcatc caggcatgta ccactccaaa ttcatccttc agcatacctg ccagccaaac
    11281 caagcctccg ttggcaagta tcttggccag attataaaaa gctccctgcc aaccgatata
    11341 cttggcttgc tgggtagcag tcagttcagt caggtatact ccgtcacccg caatgtcatg
    11401 agtcgcacca ctgagagcaa tgatccccat cagagcgatg gcataacgaa aaaagtcggg
    11461 cagcggcagc gaaagtgcta ccaatgcaaa tgccagtccg gtaatgattt ccgtagcgac
    11521 aacaaagtac tttttcgttt taaacatttc cagaaacgga ctccataaag gcttcaatgt
    11581 ccagggaagc ataatgagag aagtccagaa agcaatctgt gcattcgaca cttccatatc
    11641 ggaaaacata aggacagaaa ccatcgaaag ggccacaaac ggcaatccca tagcaaagta
    11701 aacagtaggc acccaacata cagggcttat cggcttttta ttcatcagtt agttttttat
    11761 aataattcca tcggttaaca attccagtaa gcaaagatag gggatattaa aaacataacc
    11821 caagattacg acaagaagtt gctttcatta tttaataata caactcaccc gggaaaacta
    11881 ctaacctcta tcaccctttt tttattaaac tttatcaata cgacacacgc aaagaagcac
    11941 cgaagacttt catccccgat gcctctcgcc cccttatcta caatctaaac acctctattg
    12001 cttcacatat aaatttatct cagcaaaccc ggtataatta tccggagtca gacagtttat
    12061 tctgaattcc tttacattcg ggataggtgg ttcgatggcc gcatattgcg gatcagcccc
    12121 tttaaaattt ctgaaagtca agactctcgg gtaagtaacc cactcggttt caccctcttt
    12181 ccgaacctta atctcagcac ttctcagatt ataacccgaa ccgtaggcac tctgtttagt
    12241 gaccgaaaat ccggttaagg taacaggccg gtccagtagc gtattccacc aacactctcc
    12301 ggcattagcc actccccatg taaaccaagt agtatttatc tcaccgtcaa tagccagatg
    12361 tgcaccatat ttggcatcat catcggcata aacattgctg caacttacac tccacgcact
    12421 tcgatctaca gcggaccaat tcccgggttt cgtataactg gtataaagca cgctggtata
    12481 aatccggata taaaccgtct tcatagatgt actgacagcc tgttcgtcca tgcccgtaac
    12541 tcctttaagc gccacgggaa gcacatatcc gtcaggatta gtcaactttt ctatattctt
    12601 caaaacgacc tgaaaagatg aatcggccac tgtctgtccc gtttttaaga caacttcact
    12661 tgtttcaatg gtataattat cttggggcaa caacttacat ttcgttttat tggcagaatt
    12721 gtaagtatcc actttcagcg tatctactcc caaagcggca gtgacatccc gcgtaaccag
    12781 ctgtacggca cacaattgta tttcaaaatc agaacggtcg gcagtagagg aattgctcac
    12841 acaatccacc actaccgcag cacccatttc ggcccccggt gcaactcccg ttctgatata
    12901 tatcttttga tatttgtcca tttcatcatc atcgttgctg cacgaagcca acgatacaaa
    12961 gcctgttatc aggcagatta aggtcacaaa attcaaatgt ctattcatat cttatcttct
    13021 ttttacatag ttattgctta tcaaaacgaa catgctcttt ccagacaaga gttcctcctg
    13081 ccaccaaatc gtatccgtgt ccggtacagt cggcaaaggc atttccttta ccttcatcca
    13141 ttttccaata gcctatcagg ttcggatcgg cgggtttcac ggcaaaatac atgttggact
    13201 gaatttgcgt ctggctgatt gcgctcttcc aaagacgcac ctgggccatc tgacaattgt
    13261 tgcggaagta gctaccgctc gaaaccatgt tcatcttgtc gaatcttacc gggccaccct
    13321 ttgtctgcag agtcacgtcg agcactccgt tgatataaat cgacaataac ccggaagaat
    13381 tataaacgaa ggccagatga taccacttat tcttctcaaa caaagtcacc gtattgacct
    13441 gacttccaag tgtcttcacc tgtaatgaat tataagggat catagcgtca ccgaaacgga
    13501 tataaacctc gtggtcgctg ctgcccgaat taaatatagc ctgattatta atatcgaatc
    13561 cgtccatctg tacccaagcc tcgagtgacc attcattggt tgtcactccc cacaattcgt
    13621 ccttggcggg cttcacggca ttggtcgtat tcataaacgg tacagactgt atcagcggct
    13681 tatccagcaa aatgataaac ttcgacgaaa gcccgattgt ggacaccggt ccctgaattt
    13741 ctgtgagaga taccggaata gcatacaatt ctccgttttc gtttgaataa ggtttcactc
    13801 taaactcact ggggattgcg ctaacatcgc ctgccgctat ctttatctct ttgtcataag
    13861 taaaatactg ctcgggaagg acttcgtacg aagtttcatt agcttcattg tactctttaa
    13921 gaatagaagg atctaccgtc aggacagcag tcacattttc ggttacaggc tgtcccacac
    13981 gtacggtcag agtagttgtt gttacatttt caggatcaac ggtaaccttt gccgaaccat
    14041 tctcggatgc ttcattcaaa taaatcgcat tgtcgataac ctggtaatcg gcatcgttgc
    14101 atcctgccag gatcatcggc agaacgaaac aggcaagcaa atattgtttt attgttattc
    14161 ttttcataat caaattcttt aaagtcattt tacagcagga ttcattattc tgattgcttc
    14221 acgcaggtac ttatattcga tgtcgcccgg atagtcatat tccatgtgat aggtgcctac
    14281 tccccccttc cgtacctgtt ttccgtcaat agtcggagtc cagcgtgcca tgccggcaag
    14341 tgctctcatt ttgtttccgt aacgatctac ataatcacct cctcctgtcg gagcataaga
    14401 ttcgaaattc tccgtaacga tgtacatatt agccactttc tccggaggaa gtattccttt
    14461 aaagttggca atcgtaccag ccagacgtct gtcaagatta gcgtcggaat tacccgcaag
    14521 gttagagtat gcctgcacaa tgaaatagtc aaagtaaggc ccggtttccg gatgaatact
    14581 ttgaggctcg ccatcaatca caagtaaccg tcccgtaccc gatttaggtc cgattcttt
//
