LOCUS       gnlProkkaLNGHCDPB_25   16019 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNGHCDPB_25.
ACCESSION   gnlProkkaLNGHCDPB_25
VERSION     gnlProkkaLNGHCDPB_25
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:40:01
            Original ID  :: gnl|Prokka|LNGHCDPB_25
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16019
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16019
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5665:6019]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5666..6019
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..16019
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16019
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(184..420)
                     /locus_tag="ctg25_1"
                     /transl_table=11
                     /translation="MLTSYSSLIKILLFDNQLLIFWMHSVVKFFSYVQDVRSCLFIKLP
                     LRLSIACLSTYFHILLSATLVLCILLLSLFAKR"
     CDS             complement(568..1203)
                     /NRPS_PKS="Domain: oMT (51-151). E-value: 4.4e-15. Score:
                     46.5. Matches aSDomain: nrpspksdomains_ctg25_2_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 99.4; E-value:
                     3.7e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_2"
                     /transl_table=11
                     /translation="MNKRGFVSRILQNFRKPEGFFGRMILWGMNTGHASLAQWGMSCLQ
                     WQPEWSVLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYLGTRCFIEQ
                     GGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLICCEISDPANKAW
                     TGLVEGMEIHSCDELKAILSKSGFTDTAIFRTKKEELCLVSHRQTVRL"
     aSDomain        complement(751..1050)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg25_2_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="4.40E-15"
                     /label="ctg25_2_oMT.1"
                     /locus_tag="ctg25_2"
                     /protein_end="151"
                     /protein_start="51"
                     /score="46.5"
                     /tool="antismash"
                     /translation="VLDIGCGGGANLLQILQRCPQGKAYGIDISSESVTFARKKNKKYL
                     GTRCFIEQGGVHRLPYPDYAFDAVTAFETVYFWGNLQHAFTEVARVLKPGGSFLI"
     CDS             1509..2849
                     /locus_tag="ctg25_3"
                     /transl_table=11
                     /translation="MNNVQQVKTYSQRKISDFLFILWAGGAALLSYSLVYALRKPYTAA
                     GFDGLEAFGMDYKVVVTIAQILGYVLSKFIGIKLISELKRENRMKFILISIILAEASLI
                     LFGLLPAPYNIVAMFLNGLSLGCMWGIIFSFIEGRRMTDILASLLGVSMVISSGTAKSA
                     GLYVMDTLNISEFWMPALIGGVALPLLALLGYALNRLPQPTAEDIAMKSKRETLNGKQR
                     WELFKNFMPFLTLLFIANVVLTILRDIKEDFLVKIIDVSQYSSWMFAQVDSVVTLIILI
                     IFGLMVFVRSNLKALSILLGLIIASMVVMAVVSFGYEQLQLNAIAWLFIQSLCLYLAFL
                     TFQTIFFDRFIACFKIRGNVGFFIAMNDFLGYTGTVIVLAVKEFFSPDINWTAFYNLMA
                     GYVGIICFVAFVCSFIYLHQRYRRENYGKTGVFRKKEEEKEVPDFVY"
     CDS             2893..4404
                     /locus_tag="ctg25_4"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITERWDI
                     TTPVTVFAGPGNNGGDALAVVRMLAEKEYKVEAYLFNPKGELSADCQTNKELVEMMDNV
                     KFSEVSTQFVPPALTMDHLVVDGLFGSGLNKPLSGGFAAVVKYINASPATVVAIDIPSG
                     LMGEENTFNVKANIIRAQLTLSLQLPKLAFLFAENSEFVGEWKLLDINLSREAIEETES
                     NYALLEAEEIHALIKPRNTFSHKGNFGHALLIAGSYGMAGASILAARACMRSGVGLLTV
                     HAPIRNNDILQISVPEAIIESDASDTYFACPTDTDDYQAVGIGPGIGRSEETEAALLEQ
                     LSGCQTPLVLDADALNILANHRHALTTLPKGSILTPHPKELERMVGKCQNSYERLMKAC
                     ELARTAKVHIILKGAYSAIITPSGKCYFNSTGNPGMATAGSGDVLTGVVLALLAQGYPA
                     EEAAKIGTYVHGLAGDFARKKQGVISMTAGDIISNLPLAWRLVSE"
     CDS             4477..5532
                     /locus_tag="ctg25_5"
                     /transl_table=11
                     /translation="MKKLIILTGLLLSTSAYAQTEVTAGVTRGKDYGVTYALPKTAINI
                     EVKVNKVTYTPGEFSKYADRYLRLTDVSGEPQEYWELVSVKAKSVGIPDSEHTYFVKLK
                     DKTVAPLIELTEDGIVKSINVPLSPKKSAPMQPATTQKKKINPRDFLTEEILMAGSTAK
                     MAELVAKEIYNIRESKNALVRGQADNMPKDGEQLKIMLANLEEQEAAMTEMFSGTLNKD
                     EKIFNIRLTPDKEMDNEVAFRFSKKLGIVANNDLAGEPVYITLKNLKTVNVPEDDGKKK
                     VDGIAYNVPGKAQVTLTEGKKQWFNGELPVTQFGTIEYLAPALFNKKSTVQVTFNPDTG
                     GLIKVDREEGE"
     CDS             complement(5666..6019)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_6"
                     /sec_met_domain="PF05402 (E-value: 8e-17, bitscore: 53.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1.3e-09, bitscore:
                     29.7, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVKEKINLLDVIPFRSENITAEKGSDGTVTIAFPRFKYEWMRR
                     FLLPKGMSTDIHVRLEDHGTAVWELIDGKRTVRRIIEELAEHFNYEENYESRITAYITQ
                     LQKDGFVKLVIEN"
     CDS             complement(6026..7414)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 97.1; E-value: 1.4e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg25_7"
                     /transl_table=11
                     /translation="MTEQLKNKLSDSKTLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACILMVLGCGLKYY
                     AISTTFPEGALIMGFKTQVFLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPIADYFGYTDESGSFHTNIPMPILLCLIMLCIGTIAFFIYTF
                     YDKKLDASLDAQGEEPEEPFRMKDVMLIVTNKGFWLIALLCVLFYSAVFPFIKYATDLM
                     VQKYNVDPKLAGNIPGLLPIGTIFLTPLFGTLYDRIGKGATLMIIGAVMLIGVHTLFAL
                     PILNVWWFATVIMIVLGIAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFACFGVLALIVALMLKAEDKKKGYGLQEA
                     NIKK"
     CDS             complement(7585..7965)
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="MYLLLVILMVIAAILMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWGLAAFMVVMSIATAYVVPTSSSKTQDVIMEQAQQEEQTNPYNLPVGTTA
                     PKTDAAAPVEAPATETPATPAN"
     CDS             complement(7970..8725)
                     /locus_tag="ctg25_9"
                     /transl_table=11
                     /translation="MISANLQQWIQHPETLNKDTLYELRTLVTRYPYFQSLRLLYLKNL
                     YLLHDISFGAELRKAILHVADRRKLFYLIEGERYILKPRKKNALPETEVLEEEPSLDRT
                     LSLIDAFLATVPEEVSAQTSLDYATDYTTYLLQEDDTPELEETPKLRGHELIDGFIERS
                     EEETSIRLQPADENKAISEEEQSETHHEEDEDDSCFTETLAKIYVKQHRYSKALEIIKK
                     LSLKYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(8731..9252)
                     /locus_tag="ctg25_10"
                     /transl_table=11
                     /translation="MDWNKKIMRISLLVFTLVVGISCTVSYKFNGGNINYDKVKTISIA
                     DFPIKSDYVYAPLGTKFNEDLKDIFLRQTRLKLVNNNADLEIDGEITGYNQYNQAVSAD
                     GYSSETKLTITVNVRFVNNTNHEQDFEQQFSAFRVYDSRELLTAVQDGLIAEMTKEITD
                     QIFNATVANW"
     CDS             complement(9239..10465)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 389.4; E-value:
                     3.9e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg25_11"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNTEALTRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGEDVLLLFRKFASDFAEKYRMPAIQLTEDAKRV
                     LLSYSWPGNVRQLKNITEQISIIETNREINAPILQSYLPAQSTQRLPALFGVKTGKSFE
                     SEREILYQVLFDMRQDVTELKKLVHEIMSERGAVTSNVGTFYTPAPVVTPTPSVPAIIH
                     PVKPNCPDDDDIQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAKDLNISERTLY
                     RKIKEYGLE"
     CDS             complement(10490..11587)
                     /locus_tag="ctg25_12"
                     /transl_table=11
                     /translation="MEDNKIKIGITQGDINGVGYEVILKTFADPVMLELCTPVIYGSPK
                     VAAYHRKSLDLPTNFSIVNTAAEAAHNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     KAIEEFREGLIDVIVTAPINKHTIQSEGFAFPGHTEYIEQRLGNGSKSLMILMKEDFRV
                     ALVTGHIPVREIASSITKELIQEKLAIFNRSLKQDFGIGAPRIAVLALNPHAGDDGLLG
                     TEEQEIISPAIQEMAAKGILCYGPYPADGFMGSGNFTHFDGVLAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDTVDDDI"
     CDS             complement(11592..12638)
                     /locus_tag="ctg25_13"
                     /transl_table=11
                     /translation="MKKYLFYLSMALVAVVLFSCKSGKKSVFTPTSSGRAYEVLVVVEK
                     PVWERPAGRALYNVLDTDVPGLPQSERSFRIMSTSPKDFDAILKLVRNIIIVDIQDIYT
                     QPKFKYAKDVYASPQMILTIQAPDEASFEKFVEENKQPIIDFFTRAEMNRQISFLEKNH
                     NDYISTKVGSMFNSDIWLPAELSSSKTGEDFFWAGTNAATGDQNFVIYSYPYTDKDTFT
                     KEFFIHKRDSVMKANIPGAKEGMYMATDSSTVEVRPIDIHGDYTMEARGLWRIKGDFMG
                     GPFVSHTRLDKASHRIITTEVFIYSPDKMKRDLMRRLEASLYTLQLPTEKAQEQIPMGI
                     EQEEKTNK"
     CDS             complement(12713..13747)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_14"
                     /sec_met_domain="PF04055 (E-value: 4.5e-18, bitscore: 58.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKYPLLGMTLTELQSVTKDLGMPAFAAKQIASWLYDKKVTSIDE
                     MTNLSLKHRELLKGEYDLGISAPVDEMRSVDGTVKYLYQVSDNHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTASLTANQILNQIAALPERDKLTNVVMMGMGEPLDNL
                     DEVLKALHILTASYGYGWSPKRITLSSVGLRKGLQRFIEESECHLAISLHSPFPSQRSE
                     LMPAERAFSIKEMVDLLKNYDFSKQRRLSFEYIVFKGVNDSLIYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGAGMETMTSFRDYLTSHGLFTTIRASRGEDIFAACGMLSTAKQEE
                     SNKN"
ORIGIN
        1 tttgaatact atccgatacg ttgaattatt ttattttaaa catatatcgg acataaagaa
       61 aagtatattt gtccgcctat atatttacgg gtgcaaaggt aaaaccttct tttgagtctc
      121 caaaactttt cacaggttat tttcatcata ggaagttata tgactgaata tcaaagatat
      181 aatttatctc tttgcaaata aggaaagcag caatatacat aatactaatg tggctgataa
      241 aagaatgtgg aaataagtgg agaggcaggc tatggagagt cttaacggta acttgataaa
      301 cagacaacta cgcacatctt gaacgtaaga aaagaatttt acgacagaat gcatccagaa
      361 tataagcaat tgattatcaa acaataatat cttaataaga gaactgtagg aagttaacat
      421 taacagtacg ttaatattaa cttcgtaatt gcaagatatt aattctttag agatacgaag
      481 ttaataagct attgataagg agggaaagca cttttacggg cattaacatt gttaacgtat
      541 tcgttggtaa gagcgtcccg gcattggtta caaccgcaca gtttgccgat ggcttaccag
      601 gcacagttct tctttcttcg tccggaatat ggccgtatcg gtaaaaccac ttttggaaag
      661 aatcgccttc agttcatcac aggaatgaat ctccatccct tcaacaagtc ccgtccaagc
      721 cttattggca ggatcgctta tctcacaaca gataagaaaa gatccaccgg gctttaacac
      781 acgcgccact tccgtaaaag catgctgcag gttaccccag aagtagacag tctcgaaagc
      841 agtgaccgca tcgaacgcat aatcaggata gggaagtcgg tggactcctc cctgctcgat
      901 aaagcagcgt gtaccgagat actttttatt ttttttacgc gcaaaggtga cactctccga
      961 tgaaatatct atgccatacg ctttcccttg cgggcaacgt tgcaatatct gtagcaaatt
     1021 ggcaccacca ccgcaaccga tatcgagtac actccattcc ggttgccatt gcaaacatga
     1081 cattccccat tgcgccaatg atgcatgtcc tgtattcatc ccccaaagta tcattcttcc
     1141 gaaaaaacct tcaggcttcc ggaaattctg taagatcctg cttacaaagc ctctcttatt
     1201 catttgtctg ctgatttaat atttcaggca aaagtacagt ttctgcccaa acaggcaata
     1261 cccagaaata gggaatttgt ttcctaaaag atatttgcag gtatgcatct gcttcccgtt
     1321 aaaattatga cgaacagatg cccggaggtg cgatgctctt ttcgtttccg tttcataaat
     1381 attacataaa cattacaaca taacagattc attatcaata tctattaata ataaacattc
     1441 atatattcag taacaggtct gtaacactac cctcctattt ttgcaccgga aaacaacaag
     1501 cagatgttat gaacaatgta cagcaagtaa aaacttattc gcagagaaaa atttctgatt
     1561 tccttttcat tctttgggca ggcggagcag cgctgctctc ctattcattg gtatatgcac
     1621 tgagaaagcc ttatacagca gccggatttg acggacttga agcgtttgga atggactaca
     1681 aagtggtagt taccatcgcg caaatattag gatatgtact ttctaaattc atcggaatta
     1741 aattaatctc cgaattaaaa cgggaaaacc ggatgaagtt tattctgatc tccataattc
     1801 tggctgaagc ttcgttaata ttgttcggac tgttgcccgc accttataat atagtagcca
     1861 tgtttctgaa cggactttca ctgggatgta tgtggggaat catttttagc tttatcgagg
     1921 gaagacgaat gacggacatt cttgccagct tactcggagt cagtatggtc atcagctcgg
     1981 gtaccgccaa gtcggccggt ttgtatgtca tggacacttt gaacatcagc gaattctgga
     2041 tgcctgccct gataggcgga gttgcccttc ctctacttgc cttgttggga tatgcactca
     2101 accggcttcc acagccaaca gccgaagaca ttgccatgaa atcgaaacgg gaaacactga
     2161 acggcaagca acgatgggag ctatttaaga atttcatgcc tttcctcact ctgctcttta
     2221 tagccaatgt ggtactgact atcttgagag atataaagga ggacttcctg gtaaaaatta
     2281 tcgatgtctc tcaatactct tcgtggatgt ttgcacaggt agacagcgta gtaaccctca
     2341 ttattctgat aattttcgga ttaatggtat tcgtcagaag caacttgaaa gcactgtcga
     2401 tattactggg attgatcatt gccagcatgg tagtgatggc agtcgtttcg tttggttacg
     2461 aacaattgca gctgaacgcc atcgcctggc tattcatcca gagcctgtgt ctctatctgg
     2521 cttttctcac tttccagact atcttcttcg accgttttat cgcttgcttc aaaattcgag
     2581 gtaacgtggg tttcttcatt gctatgaatg attttctggg ctatacggga acagtcatag
     2641 tattggctgt caaagaattc ttttcaccgg acattaactg gacagctttc tacaatctga
     2701 tggcaggata tgtgggaata atctgtttcg ttgcttttgt atgctctttc atctacctgc
     2761 accaacgcta ccgcagggag aattacggaa agacaggggt attcagaaaa aaagaagaag
     2821 aaaaagaagt tcccgatttc gtatattaat tgctatcttt gtgggtcaaa aaacttaaaa
     2881 tgaaagttca ccatgaagat ttttccaagt agcagcatca agaaactgga tgcttacacc
     2941 atagaacatg aaccgattgc atcgatcgac ctgatggagc gggccgcaca ggcactgacc
     3001 aaagccatca ccgaacgctg ggacatcaca actcccgtca cggtatttgc cggaccgggc
     3061 aacaatggcg gagatgccct tgccgtggtc cgaatgttgg cggaaaagga atacaaggtc
     3121 gaagcctatc tgtttaaccc gaaaggggaa ctgtctgccg actgccagac caacaaggag
     3181 ctggtagaga tgatggataa tgtgaagttc agcgaagtaa gcacacagtt tgtacctcct
     3241 gccctgacaa tggatcatct ggtagtggac ggactttttg gttcgggact taataagccg
     3301 ctaagtggcg gttttgcggc agtagtgaaa tatatcaatg catcgcctgc caccgtagtc
     3361 gccatcgata tcccctcggg actgatgggg gaagagaaca catttaatgt aaaagccaat
     3421 atcatccgtg cccaattgac attgagcctg caattgccga aactggcttt cctctttgcc
     3481 gagaattccg aattcgtagg cgaatggaaa ctgttggata tcaacctcag tcgtgaagcg
     3541 attgaggaga cggaaagcaa ttatgcctta ttggaagcgg aagaaataca cgctctgatc
     3601 aaaccccgta acactttctc acacaaagga aactttgggc atgctctgct gattgccggt
     3661 tcgtacggca tggcaggcgc gtcgatactg gcagcccgcg cctgtatgcg ttcgggtgta
     3721 ggcttactga cagtccatgc acctatacgc aacaatgata tcctgcagat ttcggttccg
     3781 gaggcaatta tcgaatcgga tgccagcgat acctactttg cctgccctac agatacggat
     3841 gactatcagg ctgtaggaat cggtccgggc atcggacgct cggaagagac cgaagctgca
     3901 ctgcttgaac aactcagtgg ttgccagaca cctctggtac tggatgccga tgcactaaac
     3961 atattggcca accaccgcca cgcactgacc acattgccca aaggctctat tctgactccc
     4021 catcccaaag aactggaacg catggtgggc aaatgccaga actcatacga acgactgatg
     4081 aaggcctgtg aactggcccg aaccgccaaa gtacatatca tattaaaagg ggcctattcg
     4141 gcaattatca ccccctcggg caagtgctat ttcaactcta cgggtaatcc gggtatggca
     4201 acagccggaa gcggagatgt attgacaggt gtcgtgctgg ctttgctcgc acagggatat
     4261 ccggctgaag aagctgccaa aatcggtact tatgtacatg gcctggcagg tgatttcgca
     4321 cgcaaaaagc aaggcgttat cagcatgacg gcaggagaca ttatcagtaa tctgccattg
     4381 gcttggcgtc tggtaagcga ataaaagtta acaacttatg attttccaaa taacttcatt
     4441 aactttgttt tttaaaccag ttaaaataaa ccggaaatga aaaagctaat tatactgaca
     4501 gggctgttac tctctacctc ggcttatgcc cagaccgaag ttacagcggg agttacccgg
     4561 ggaaaagatt acggtgtaac ctatgcactt cctaaaacag caatcaatat tgaagtcaaa
     4621 gtcaataaag tgacatatac tccgggagaa ttcagcaagt atgccgaccg ttatctccgg
     4681 ttgaccgatg tgtcgggtga gcctcaggaa tattgggaac tggtcagcgt caaagcaaaa
     4741 tctgtcggta tccccgatag cgaacatacc tattttgtca agctgaaaga taaaacagta
     4801 gctccgctaa tagaattgac cgaagatggt atcgtaaaat caatcaacgt accgctatct
     4861 cctaaaaaat cggctccgat gcaacccgcc acgacacaga aaaagaagat aaatccacgt
     4921 gattttctga ccgaagagat tctgatggca ggttctacag ctaaaatggc ggagttggtt
     4981 gccaaagaga tttataacat tcgtgaaagt aaaaatgccc tggtacgcgg acaggcagac
     5041 aacatgccca aagatgggga gcaactgaag attatgcttg ccaacctgga agagcaagag
     5101 gctgccatga ccgaaatgtt ctcgggtacc ttgaataaag acgaaaagat attcaacatc
     5161 cgcctcactc cggataagga aatggacaac gaagtagcct tccgcttttc gaagaagctg
     5221 ggcatagttg ctaataacga tcttgcagga gagccggttt atatcacgct gaagaatctg
     5281 aaaaccgtca acgtaccgga agacgatggc aaaaagaagg tggacggcat tgcctataat
     5341 gtgcccggca aagcacaagt aacactaacg gaggggaaaa agcaatggtt taacggagaa
     5401 cttcctgtca cacaattcgg taccatcgaa tatctggctc cggcgctttt caataagaaa
     5461 tcgactgttc aggttacttt caacccggat acaggaggct tgatcaaggt agatagagaa
     5521 gaaggagaat aaaacataat caaaaactcc ggccgatctt aaatgaagtg caccccaaaa
     5581 gttcatgttt aacttttagg gtgcacttca tttttaaatc agccggagtc tctttattat
     5641 attccgatag tatatcgtaa tgcaatcagt tctcaatcac taatttcaca aatccgtctt
     5701 tctgcaactg agtgatataa gccgtaatac gtgattcgta attttcttca taattgaagt
     5761 gttctgccag ctcttcaata atccggcgta cggttctctt tccgtcaatc aactcccata
     5821 cggcagtgcc atgatcttcc agccggacat gaatatccgt agacattcct ttaggcaaca
     5881 agaatcgccg catccactcg tatttaaacc gggggaaagc aatggtaacg gtaccatcgc
     5941 ttcccttttc ggccgtaata ttttcactac ggaaaggaat tacatccaaa agatttattt
     6001 tctctttcac gtctgccata tactgttatt ttttgatatt tgcttcctgc agtccgtatc
     6061 ccttcttctt gtcttccgct ttcaacatta aagctacaat cagagccaaa acaccgaaac
     6121 aagcaaagat agccataggc aaagtatagt cataagtctg cgctccatcc acaacaggac
     6181 ctttgcaata ggtattcaac acccatccga tcaacagagg tacccccatc aatccccagt
     6241 tctgcaccca gaaaatcaaa gcataggcag tacccagttg tttctccgga ataattttcg
     6301 gaacagaagg ccacatggcc gaaggcacca gtgaaaaagc aatacccaga acaatcataa
     6361 tcacagtggc aaaccaccat acgttcagaa tgggaagcgc aaacaaagta tgcacaccaa
     6421 tcagcatgac ggcaccgata atcatcaacg tcgctccctt accgatacga tcataaagag
     6481 taccaaacaa cggagtcagg aagatggtac ctatcggtag taatcccgga atatttccgg
     6541 ccagcttagg gtctacgtta tacttctgca ccatcaagtc ggttgcatat ttaataaagg
     6601 ggaaaacagc agaatagaat agtacacaca ataaagcaat cagccagaag cctttattgg
     6661 tgacaatcag cataacgtcc ttcatacgga acggttcttc cggttcttct ccctgagcat
     6721 ctaaagaagc gtcaagtttc ttatcataaa aggtataaat gaaaaaggcg atagtaccga
     6781 tgcacagcat gatcaggcac aacaaaatag gcatcggaat attggtatgg aaactgccgc
     6841 tttcatccgt atagccgaaa taatcggcaa tgggaacggt aagcaccata gccaaagtgg
     6901 taccgatacg tgcggttgcc atctcaagtc ccatagccaa agccatctct ttacctttaa
     6961 accatttcac gataatctta gagacggtga taccggcgat ctctacgccg acaccaaaga
     7021 tagcgtatcc taaagccgcc agaaagacct gagtcttgaa acccataatc aaagctccct
     7081 caggaaaagt agtagagata gcataatatt ttagtccaca acccaacacc atcagtatac
     7141 aagctcccat accggtgaaa cgaactccca tcttatcgag aataatacca ccgaaaatca
     7201 acatgagcag gaatacattg aaccatccgt aagcactggt aaagaatccg tagtccaaac
     7261 tatcccagag aagctctttc tcgagcatag gctttaaagg ggacattaca tcggtgagga
     7321 aatagccgca aagcatagta aacgcgacca gagcgagcac actccaacga agtgttttgg
     7381 agtcactcaa tttgtttttc aattgttctg tcattgtaat atttaaactc agaaattagt
     7441 aaaagtgtta ttgcgaacaa aggtaactaa atctgccttg tatgcctaac aaaaagatgc
     7501 attttacggc aaaaaataag cgaagctgca agtttcggtt tgaaattgca gcttcgctta
     7561 tcgtttctta aaaagaatct gttgttagtt tgccggagta gccggagttt ctgtggcagg
     7621 tgcttcaacc ggagcagcag cgtctgtctt cggtgcagta gtacctacgg gcaggttata
     7681 agggttggtc tgctcttcct gctgtgcctg ttccataatg acatcttgtg ttttagaaga
     7741 agaagtcgga acgacatacg cagtagcaat gctcatcaca accataaatg cagctaagcc
     7801 ccaagttgct ttttccagaa agtctgtagt tttgcgtaca cccataatct ggttagatga
     7861 tgagaaccct gaagcaagac caccgccttt tgagttctga atcaacacaa tgaagcacat
     7921 cagtatggct gcaataacca ttaagataac taataataag tacattttgt tattttgatt
     7981 tagcgttaat aatcaatttc tctaaaaatc tgatttggtc tgcaaagtaa gcattttttt
     8041 ttggatattt caaacttaat tttttaataa tttcaagcgc cttggaatat cgatgctgtt
     8101 tgacgtatat tttggccaat gtttcggtga aacagctatc atcttcatct tcttcatgat
     8161 gcgtctcgct ctgttcctct tcggagatag ctttattttc atctgccggt tgcaaacgga
     8221 tagatgtttc ttcttcactt ctttcgataa agccgtcaat caattcatga ccgcgaagtt
     8281 tgggagtttc ttccagttcc ggtgtatcgt cttcttgcag caaataggtg gtatagtccg
     8341 ttgcatagtc caggcttgtc tgggctgaaa cctcttcggg aacggtggcc agaaaagcat
     8401 cgatcaggga aagcgtacga tcgaggctgg gctcttcctc taaaacttct gtttcgggaa
     8461 gtgcgttctt tttccgaggt ttcaaaatat atcgttcacc ctcaatcaga taaaacagct
     8521 tccggcgatc agccacatgc aatatggctt tacgaagctc ggcaccgaaa gagatatcgt
     8581 gcaacaaata tagattttta agatagagta atcgcagtga ctgaaaataa ggatagcgtg
     8641 tgacaagcgt tcgcaactcg tacaaagtat ctttattcag cgtttccgga tgctgaatcc
     8701 attgttgtaa gttagcagaa atcattctaa ttaccagttt gctaccgttg cgttaaatat
     8761 ttgatctgta atctctttgg tcatctccgc aatcagtccg tcctgaacgg ctgtcagcaa
     8821 ctccctcgaa tcatagacac ggaaggccga gaactgttgc tcgaagtcct gttcatgatt
     8881 cgtattgttc acaaaacgaa cattcactgt gatggtcaac ttggtttcag aagagtatcc
     8941 gtcggccgaa acagcctggt tatactggtt gtatccggta atctctccat caatctcgag
     9001 gtcggcattg ttattcacca gtttcagacg ggtctgacga aggaaaatgt ctttcaggtc
     9061 ctcgttgaac ttagtgccta acggtgcata aacatagtcc gacttaatag gaaagtcggc
     9121 aatagagata gtctttacct tatcgtaatt gatattacca ccattaaact tataagaaac
     9181 agtacacgaa attcctacta ccagtgtgaa aaccagcagt gaaattcgca ttatcttttt
     9241 attccaatcc atattctttt atttttcggt aaagggtacg ctcggatata ttaagatcct
     9301 ttgccgcgct ttttcgcttg ccatgatgct tttcaagggc tttgcgtatc atttctttct
     9361 cgacttcgtc caacgaaagc gactcttcca catactcttc ggtatcttgt atgtcatcgt
     9421 catcgggaca attgggcttg accggatgaa tgatggcagg cactgagggt gtaggggtta
     9481 ctaccggagc cggcgtataa aacgtaccga cattagaggt taccgctccg cgctcggaca
     9541 tgatttcgtg tacaagcttt ttcagttcgg tcacatcttg tcgcatgtca aaaaggacct
     9601 gatataagat ttcacgttca ctttcgaagc tcttccctgt ctttacaccg aacagggcag
     9661 gcaatcgctg cgtactctgg gcaggcagat aagattgcaa gataggggca ttaatctcac
     9721 gattggtctc aattatagag atttgctccg tgatattctt caactgacgc acattacccg
     9781 gccaggaata agacagcaaa acccgtttgg catcttcggt cagctgtatg gcgggcatac
     9841 gatacttctc tgcaaagtca cttgcaaact tacggaacag taacagcaca tcttctccac
     9901 gctcccgcaa aggagggatc tggatgggca ccgtgttgag acgatagtat aaatcctcac
     9961 ggaaacgtcc ctctgcaatg gcctgggtca aattgacatt ggtagcagcc acaatgcgga
    10021 catccgtttt ctgtactttg gaggagccta cttttataaa ctccccactc tcgagtacac
    10081 gaagcaaacg tgcctgcgtg ggcaaaggca attctccgac ttcatccaga aaaatagttc
    10141 cgccgtcggc ttcaccaaaa tagccctttc gctcaccgat ggctcccgta aaagcccctt
    10201 tttcatgacc gaacagttcc gaatcgatgg ttccttcagg aatagcacca cagttgacag
    10261 caatatactg tccatgcttt cggcgactgt attggtgaat gatctgagga aaactttcct
    10321 taccgacacc actctctccg gttattagca cggacaaatc ggtaggtgcc acctgtatgg
    10381 caacatctat cgcacgcgtc aaagcttcag tgttaccaat aataccgaac cttagtttta
    10441 cctgttgtat ttccgctttt gtcatattcg cactaaactc ccttcctgat taaatatcat
    10501 catctactgt atcgagcttc agtttatcac tgtcgtctcg tttctcgtaa tactgtttac
    10561 gtaacggatt ggcatgtgct tccttctcac gttgacggtt acggaatacg tcgatcgcta
    10621 cataaatagc ctgacggaat gaatcttcgc aagcaacgcc ttttcctgca atatcatagg
    10681 ctgtgccatg cgcgggagaa gtgcgtatca ccggcaaacc cgccgtgtag ttcacacctt
    10741 catccatggc caatgccttg aaaggagcca atccctgatc gtgatacatg gccagtactc
    10801 cgtcaaaatg ggtgaaattg cccgatccca taaatccgtc agccggataa gggccatagc
    10861 acaagattcc cttggcagcc atttcctgaa tagcaggaga aatgatttcc tgttcttctg
    10921 taccgagcaa tccgtcgtct ccggcatgcg gattcagtgc caacactgcg atgcgcggtg
    10981 caccaatccc gaaatcctgt ttcaacgacc ggttgaatat ggcaagtttc tcctgaatca
    11041 gttccttggt tattgaagag gctatctcgc gaaccggaat atgtcctgtt accaaagcta
    11101 cccggaaatc ctctttcatc aggatcatca gtgattttga accattcccc agacgttgtt
    11161 cgatgtattc cgtatgtccg ggaaaagcaa atccttcgga ctgaatcgta tgcttattga
    11221 taggagccgt cactatgaca tcgatcaagc cttccctgaa ctcctctatc gccttctcaa
    11281 gtgctcccaa agctgcttta ccggcttccg gatcgggttt tgagaactct actttcacct
    11341 cgtcatccgt acagttgacc acgctcaggc gattgtgggc agcttctgca gcggtattga
    11401 caatactgaa gttagtaggc aaatcaagcg acttgcggtg atatgcagcc actttcggag
    11461 agccgtaaat gaccggtgta cagagttcca acatgacggg gtcggcaaac gtttttaaaa
    11521 tgacttcgta tcctacccca tttatgtctc cctgagtgat gccaattttt attttgttat
    11581 cttccatttt gttatttgtt agttttctcc tcctgctcta tgcccatcgg aatctgttcc
    11641 tgcgccttct cggtaggaag ttgcaaagta tacagagatg cttccaatcg gcgcatcagg
    11701 tcacgtttca ttttatcggg tgagtaaata aatacttctg tagtgataat acggtggctg
    11761 gctttatcca gacgggtgtg cgaaacaaac gggccaccca tgaaatcgcc ctttatgcgc
    11821 cacagtccgc gtgcttccat tgtgtaatct ccatgaatat caatcggacg aacctctacg
    11881 gtagacgaat cagtcgccat gtacataccc tctttggcac ccggaatatt agccttcatc
    11941 actgaatcgc gcttatggat aaagaactct ttcgtaaagg tatccttatc tgtatacggg
    12001 taagagtaga ttacaaagtt ctggtctccg gtagcggcat tagtacctgc ccagaaaaag
    12061 tcttctcctg tcttcgaact gctcagttca gccggaagcc agatatcact gttgaacatg
    12121 ctacctactt tcgttgaaat atagtcatta tgatttttct ccaggaaaga gatctgacgg
    12181 ttcatttcgg cacgggtaaa gaagtctata atcggctgtt tgttctcttc gacaaacttc
    12241 tcaaacgatg cctcgtccgg agcctggata gtcaaaatca tctggggaga tgcatataca
    12301 tccttggcat acttgaattt aggttgggta taaatgtcct gtatatctac gataataatg
    12361 ttgcgcacca acttcaggat ggcatcaaaa tctttgggag aagtagacat gatcctaaac
    12421 gaacgttccg attgcggaag tccgggcaca tctgtatcga gcacattgta caaagctcta
    12481 ccggcaggac gctcccacac aggcttctca accacaacga ggacttcata agcacgtccg
    12541 ctggaagttg gagtaaacac acttttcttg ccgcttttac aagaaaacaa cactactgct
    12601 acaagagcca tactgaggta aaacaggtac tttttcatat gcatcaattt taatgttttc
    12661 acaaatctac gaaatggtcg tatactttca tccaatgtgc tgataattta tattaattct
    12721 tgttactctc ctcctgttta gccgtcgata acatcccgca agcggcaaaa atatcttctc
    12781 cccgggaagc tcgaatggta gtgaacagtc catgtgaggt caggtagtca cgaaatgacg
    12841 tcatagtctc cataccggca ccctcgaggt ctaccccggg aatggcatga aaccggatta
    12901 agttcacccg gcagtcaagc ccacgcagca atttcaacag ctccttagca taaatcagcg
    12961 aatcattgac gcccttaaaa acaatgtatt caaacgaaag tctgcgctgt ttactaaaat
    13021 catagttttt taacagatcg accatttctt taatcgagaa agccctttcg gccggcatca
    13081 gctcagaacg ttgtgaagga aaaggagaat gcaggctgat agccagatgg cattcgcttt
    13141 cttcaataaa gcgttgaagc cctttccgca atcctacaga cgacaaagta atgcgcttag
    13201 ggctccatcc gtatccatac gaagcagtca ggatatgcag cgcttttaat acttcatcca
    13261 aattatcgag aggctcgccc atccccatca tcacgacatt agtcaactta tcccgctccg
    13321 gcaatgctgc gatttgattc aagatctgat tggctgtcag acttgcggta aatccttgtt
    13381 tacccgtcat gcagaactta cagttcattt tacagcctac ctgagaagac acgcacaatg
    13441 tcgcccgatc ctcgtccgga atatacacag cttcaacaaa atgattgtca cttacctgat
    13501 aaagatactt caccgtacca tctacggaac gcatctcatc aacaggcgcg gatatcccca
    13561 aatcatactc tcccttgagc aactctctat gcttcaacga cagattggtc atttcatcaa
    13621 tagaagtcac ttttttatcg tataaccagg aagcgatctg tttggctgca aaagcaggca
    13681 tccccaaatc tttggtgaca gattgcaatt cggtaagggt cattcctaaa agcggatatt
    13741 tgggcatatt tactacaaat atttatttat tcatgcaaat gtaaggaata aaagtcgatt
    13801 ttaaaaaaga gaagggacaa aagttaatgg gaagagggaa agagatagca aaaagaaagg
    13861 ctgttccgtg cggaacagcc tttcgtatat taaaacgatg ttatctaaaa aacaaatccg
    13921 tttttagaag aacaggtatc gtttatcttt tacatcgcct ttcagataaa gatcgttcat
    13981 aaaacgactt gccagacggg catgcatgtt ttccaatgta gcctcttctg attgggcatc
    14041 gaatgtttcg ttcagcttat ctttggcata tacctgcaac acaaatacac cgccattacc
    14101 cttgatagga gcgctcagct tattgatatc cgaaaccgaa gcgtatgcgc ctaccagcgg
    14161 ctcactacta cgcaaagcgg ctacataagc aggcgctgca aatgttacgt gttttacaga
    14221 atcacttact gcattggcca tcgatgtgta ctgggcaatt gtagttgcat tggcagcctt
    14281 catgtcggcc atgatcttct cagctttctt atcacgaatg atttcagctc tcaactgatc
    14341 ctgaacctgg gccaaaggac gataaccttc ttcgatcacg ctaaccagac caacaaccaa
    14401 catgcggtcg ctttcgccac attcatataa gccggaaact tcacccggtt ttgcagcaaa
    14461 ggcccatttc agtgcttctt tagtccctct gataccaccg attccgtgtt ctgagctata
    14521 cagatcattt ctttcgagca atttatagcc tgattcttca gcattggccg caaccttgtc
    14581 tactgtcggg ttagctgcaa taaactggct gaattcatta taagctttat tataagtttc
    14641 tttgctgaac tcaaccgcac gcttgataac ggcaacttta tatttatctt tcacagcttt
    14701 cttatcagtc acctgcaaaa tgatattacc ttgtcccaat gctacgttag agagttcgtt
    14761 tactcccaga ttgttgatag tgctgataaa tttcaagtta tcgccatcaa cctgtgcatt
    14821 ttcgtagtta gcagacgaaa tccagttgga ttcacctgtt tgtccgtact tcttagccaa
    14881 agctgtaaag tcggctccac ccttaatagc agtatagatg ctgtcagcca aagcctttgt
    14941 tttagcagcg tcttctgtgt aaacctgaat ctgacggaac tgtacagaat cggcagcagc
    15001 cactttagac aacaccttga acgaattgat agtattgtcg cctgcattgt agtaagggcc
    15061 atatacttgt ccaatcgaag ctgaatccat gcgtgcaact acatctgacg ggaaagcttt
    15121 cttggtatag tacaaatcaa catacggata ttccgatccg gtagaacgga tgaaagtagt
    15181 ataatcacca ttggcagtag ccagttggtt tgtataatca gtcacttctt gctggatagc
    15241 agctctgtct tctgcactgg ctgtcacctg tacatcgatg tatttgatgt tgcgtgtttc
    15301 aacatattgt ttgaactgtt ctttcttctt gttatagaga tctttcagtt cagactcttt
    15361 aactgtgata gtagagtcta caatagaaga ataaggaaca gcagccaaca gaacatccga
    15421 ctggtttact cttgcgtcga atgcatcctg tgcctcaacc ggattagaga aaagagcttt
    15481 agtcaccagt gcctggtatt tttccgccaa acggctctgg atcagtgtct tttctacaaa
    15541 tgaccaaagt ttgtgcattc cttcatagta ttccacatat tgagacggca tcttggtctt
    15601 gtccatttta gagtagtcag ccaagaattt cttcaacata tctttatcga aagcgcccgt
    15661 ttgaggattg cggaacggag tctgctgcag caacggattc acaccttcgt taatgattga
    15721 ttgaatttca gccttcgaaa cagtaatacc gagcttcttc gcttcttttt caatcagttt
    15781 attgttcaca tagctacgcc atacttcgtc tttcacttga ttggtctgtt catcattcaa
    15841 tgaactcatt ccgcttgaga acttgataac ctcggtatat tcttctacca tgttctggta
    15901 gtcctgagca gaaagagttt ctccattgac ttcgcctaca tcatgcgatt ggtgtggctg
    15961 gagaactttc caggcatcgc ccgcaatgaa agcaaacaaa gccaaaccaa taacgatca
//
