LOCUS       gnlProkkaEPOAKDGC_23   18945 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EPOAKDGC_23.
ACCESSION   gnlProkkaEPOAKDGC_23
VERSION     gnlProkkaEPOAKDGC_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:24:22
            Original ID  :: gnl|Prokka|EPOAKDGC_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 42065
            Orig. end    :: 61010
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18945
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:18944]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..18944
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..18945
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..18945
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(401..979)
                     /locus_tag="ctg23_39"
                     /transl_table=11
                     /translation="MKTILLNCLPPAMENCASPALSVLKHTLQNNGFKTDVLYWNLKLN
                     SFLRNYLNFGDYIHRDDIYKLLPFYIHIAIEENDQELLNKLAYSVLYHKPEIHSKGIAY
                     LYSYFYEQDKRLIHIIKECLQSINMKELLFVGFSAKFSQWIVATIIAKEIKKIYKKLPI
                     IIGGFGTPQEAQTILKNFNCFDLSSWGGR"
     CDS             1077..1334
                     /locus_tag="ctg23_40"
                     /transl_table=11
                     /translation="MYSTWLEETQWQVIKKILNLQERKRKYDLREMWNAIFYVVKIGCQ
                     WRMLPSDFAPWELAYYYYCRYSSLGEFELLLNNLREKVHL"
     CDS             1368..1544
                     /locus_tag="ctg23_41"
                     /transl_table=11
                     /translation="MDSQRVCLGNHRSLNGGIDGNKKVKGVKCHVVVDKNGFLLAVMVT
                     IACVHNSKLFIYW"
     CDS             complement(2357..2566)
                     /locus_tag="ctg23_42"
                     /transl_table=11
                     /translation="MQTIRKDIEQTEAIIVDLTSRIKVVLSPYENVLKLLSPGLSRKTV
                     EDLIAEIGVDMEAFPTEKASDLVG"
     CDS             5611..5754
                     /locus_tag="ctg23_43"
                     /transl_table=11
                     /translation="MLELCWCPNRVDTVAKDLRDYFKQFVDEDDVSHCFANKINEMPLE
                     LQ"
     CDS             7077..7319
                     /locus_tag="ctg23_44"
                     /transl_table=11
                     /translation="MTDATIATESVTGNSVQTLYADGVYGETNRAFVKKHGMDFITTGV
                     QGKTGRFDFEMTGKALQVTNKKTGEVIPVEKQEGK"
     CDS             complement(7259..7522)
                     /locus_tag="ctg23_45"
                     /transl_table=11
                     /translation="MHTMLCKITVTCLVIASMEAVLKILVPTLFLLLSSSLEIYCRHFF
                     SVIPCVYSSEKYLSGVFQLMRIFYFPSCFSTGITSPVFLFVT"
     CDS             7777..8661
                     /locus_tag="ctg23_46"
                     /transl_table=11
                     /translation="MKNTFILLLYVCISLGANAQLLWQISGNGLTKPSYVFGTHHLSPL
                     SILDSIIGFKQVMNDVEQVYGELVMDDMKIPINMQKVQQATLLPGDTTLQTLMTEAQYD
                     SIALKIKQLMGVELKMMNKLKPAALTSQIAVILAMKSMNNFNPQQQLDGWIQTEARKQG
                     KKVYGLETIDIQIKVLFNSQSLQRQAEQLFCTLMHLDLLDQMYQKMTIAYLNQDIDLIE
                     KIMKEKMDNACDFFPEEEEELNYGRNANWVKLMPPIMKEKSTLFTVGSGHLPGKLGVLN
                     MLGKQGYTIKPVK"
     CDS             10001..10684
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_47"
                     /sec_met_domain="LANC_like (E-value: 9.1e-09, bitscore:
                     26.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNSFYLEDAEIIKQLFLKSPHLQSNSLYKGKMGIVLFLYEFANL
                     TQNDAFKRFASFLLDLLWEDIEMDSPINLALGLSGIGVGIELLSQRKFIDCNNTSELCF
                     ELNNQIMTQNIYRLTDYTFETGLSGIIYYVLIHIKNNRHHSFDKVFLSEIFEKCIQIDQ
                     AKLNEISKFYISYYLDYFKGEKNNNLNPQLSHFINKKSVKNLKSMDDMGLYEGIVGYLY
                     LKYFL"
     CDS             10774..12021
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 99.1;
                     E-value: 5.2e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_48"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.4e-27,
                     bitscore: 88.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQHIFIINEKNLASSYGVGTYINEYIKCLRRFDLEIHLVTLFCD
                     EELYNLYENEFVDYINIPTTILKNTKYYHQSVCAIIKLYYAKIEKPLFHLNFHQNIFFV
                     KYIKDYFNDAIILYTIHYSCWSLQLNSDVNLFKSILSKYNSNGNLSELEHRVILEFEKE
                     KELFNKVDRIICLSNETYEILKSEYLISPTKINLIPNGIEDSYTPLLGNQKNIIRKYFH
                     IKKKEKIILFVGRLTALKGAYILLDSFKKISPYHTNYRLFIIGDGDFNLLLNQAEPYWD
                     RITFTGKIDKEKLNQLYKIADIGIIPSYCEQCSYVCLEMMMNAIPCIVSDGIGLNSIFK
                     NNINSIVAKIVDYQNPDSYILNLEKSILDMINNASKKDNISKKSRLTYLEKFTLDHMFE
                     NYKKLFLTFNIRVKEW"
     CDS             complement(12840..14603)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 68.8;
                     E-value: 8.7e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_49"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.1e-16,
                     bitscore: 52.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIAFLSSLNPRDIHNWSGTLYYMYHHLEKDHRLTWTGWQQYEEA
                     IKFHRENFGEDPPFSPEKYAQLFGKMLTDLFHYEYYDLIICRDYFFLAYLTTDIPVVYI
                     GDTTCRLFNQYLKIADSPKLDLAEKLEERSTQKATHIVYASEWAKNSAINHYHATPEKI
                     SVIEFGANIDNIPEYTDHDCISVCNLLFIGKNWEMKGGNKTIEIFYSVKKKGIPCTLTI
                     IGSTPTQIPKDTDIVVYPYIDKSSSEGQKLFEQILSQSHYLIAPTLFDCFGIIYCEASA
                     YGIPVLTTDVGGISQAVHNGYNGFLFTADTPASEYADKIIDLYMNKDMYTNLRRECRKH
                     FETRLNWNVWKKRMNDLLISIKEREEGTYIPVYVINIKEREERRKHIVREFEGKSEFEF
                     HLVEACTHSKGTIGLWNSITKVIKMAKEREDDVIVICEDDHFFTENYSSGLLFKEIQEA
                     YMQGAELLSGGIGGFGQAVPVGYHRYWVDWFWNTQFIVIYSSAFDTILSYEFQENDTAD
                     GVLSKIIHNKMVIYPFISEQKDFGYSDVTLGNMEYPGKIREFFTRTNAKFKMIRTIQEL
                     SVLEYCIKYTL"
     CDS             complement(14611..15381)
                     /locus_tag="ctg23_50"
                     /transl_table=11
                     /translation="MEPISIVIPVRIDSTERKENLHCVLQYLLQTPFIYIDILEADQKQ
                     HFHFHPHERIRYRFIQDYETVFYRTRYLNILLKDARHVIVGIWDTDVLVPEKQLMDAIN
                     YIQKGCVLSFPYDGNFRFLDKEESQSIRKDITILHEGMGHRLIGRPSVGGAFLVNKTKY
                     LETGGENEGFYGWGPEDVERVKRLEILELPIARTKGALYHLHHERKPDIGVDNRKKARH
                     NQKVLLNTCRQSKEELTKALKNHTGIFFYLENHN"
     CDS             complement(15385..15942)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_51"
                     /sec_met_domain="LANC_like (E-value: 3.5e-06, bitscore:
                     17.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNKMGKTIALFRLYRNTKEEEWRIRAEEMLDDIWNECTKDMSLA
                     YRDGLCGIGAGTEYLIQNGFVEGNTDEILAEIDSRVFAAINVRPPFDLSIEQGILGLAC
                     YLYHRLYYRKDSEEPTVLDLKEYTIYLIDWIAEALQDNSTDKDYYEFYFILVLLHTLNI
                     MNAKIENLLECCDKKLLTSVYK"
     CDS             complement(15952..16794)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_52"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.1e-37, bitscore:
                     120.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQRIFIIGGEWIYFKIYSGPKTIENIFINDIMCKINLLIKQRMI
                     DSFFFVRYMDPNYHIRLRLHCTNINNYAFILHLIYKTLNRYVKDLIITKVQLDTYTREL
                     ERYEYNEIVHFETFFYYDSCLITKCLKRLNCTDQDRYKISMKFIDSIMDICNFSLDEKI
                     NFTEKNSKAYFLELYQSDCTIGHILNLKYRKYRNEIEKCLNDESKHCWWNKEIKKNIYI
                     MRTIPLNILTGKNNKLSSIIHMHVNRMYRINQRTVELVIYWYLNKYYRSKKAILCNLK"
     CDS             complement(16791..18944)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     400.1; E-value: 2.9e-121)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_53"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.2e-123,
                     bitscore: 405.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.7e-10,
                     bitscore: 31.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYIPYNQCIIRTPLFPINYIDKIEDFELSIFQQSFKEAVYIATP
                     VLYQELYIKNNINERTINSAIKYYVRSCTRCTPYGIFAGCDIVPIRIDDNYSNIIMSDL
                     KNYKTYTRIDMNYLCELIRKLDLMPQIQNAITYHVNTTSYFLGKNLRYIEYRINKSKRN
                     YTFSEISHTPYLNNIIKALKKTPLTKKEIIRLLIKNKEIEEEEALNFVQTLIDEQILIS
                     NLEPSVVGEDLIQQLHHNLSEINYNLEFINSLIYLLKECDKESLGNKESIINNIYRLLS
                     DGMLFEQDTLMQVDTLNKVKQGIIGNNITKVIDKCIYFFSKFQPSHKSETFELFKRRFY
                     EKYEEQEVPLVVALDPQVGIGYGNWTENNGDINPLLQGLPNPFLDRSYKIDMDLTPVTM
                     LLIKKYEEAIKQGLHEIEILDEDLNEFEERDLKLPQCSVMLSVLSNDDTPSILLKGIIG
                     GATSRLISRFEYLDSKIENFVNEINKRDELYYKDCIVAEVMHLPEDRIGNIQMHPNNRQ
                     YGICYLSSPTTKYVKKIIPIDDITISVYHGQEVILKSKKNKKRIIPMLSTAHNTKNGLP
                     IYSFLSDYINQESMSYSFDWGSYFHNKSFLPRVIYSNVILKPARWLIHPNEFPQNKNLN
                     SDELYSWKLKQRIPDEILITLGDNQLYINFNKEHLVKIFISELKKKRPIILEEFLYSSK
                     NINLVESQEGFFANELIINLYKK"
ORIGIN
        1 tagcgtatcg aatcttatat tatcgttagc tacgatatta ttatcaagaa aaaatataga
       61 tgtgcaatta aatttttcaa tgtaatttaa tatttcgttt ttaacgcttt ttacggattt
      121 agttctaaat ttatatcctt tgtttaaaaa gcaaaattta caccttcccc aattgcaccc
      181 tctacttgct tcaattggaa tcattaaagt aagaggtaat ttatgaagtt ttatttgtga
      241 aaaataatct gacatatcaa aactgacatt gtttaaattt atgtaagtat taatcgcttt
      301 gttagacgtg attgtattac aatttcgata acaaatatgc ggaattttgt taagtactcc
      361 ttcagaaaaa ccatgttgag ccagtaatag tgttgagttt tcaccttccc ccccaagatg
      421 acaagtcaaa acaattaaag tttttaagaa tagtttgggc ttcttggggt gttccaaacc
      481 cacctatgat tataggtagt tttttatata ttttctttat ctctttagct ataatagttg
      541 ccacaatcca ttgtgagaac tttgcagaaa aaccaacaaa tagtagttct ttcatgttta
      601 tggattgcag acattctttg ataatatgaa ttaacctttt atcttgttcg taaaaatatg
      661 aatataaata ggctatccct tttgagtgaa tttcaggctt atgataaagg acagaatatg
      721 ctaatttgtt caagagttct tgatcatttt cttcaattgc aatatgaata taaaaaggta
      781 ataatttata gatgtcatct ctatgtatgt aatctccaaa gttgagataa tttcgtagaa
      841 aagagttaag ttttaaattc cagtataaaa catctgtttt aaatccatta ttttgtaatg
      901 tatgcttaag aacagagagt gcaggtgatg cacaattttc cattgcggga ggaaggcaat
      961 ttaataaaat cgttttcata ttagagcctg tttaaatttt ccattttgaa ataaaaagag
     1021 tgtttttttc tttccttgaa aatgattatt ttttagttac cacgcttaaa ataatcatgt
     1081 attcaacatg gttagaagaa acacagtggc aagttatcaa gaaaatcttg aatttgcaag
     1141 aaaggaaacg gaaatatgat ttacgtgaaa tgtggaatgc tattttctat gtagtgaaaa
     1201 tcggttgtca gtggcgtatg cttccctccg atttcgctcc ttgggagttg gcttactact
     1261 attattgcag atactcctct ttaggtgaat ttgaattatt attgaacaac ttacgagaaa
     1321 aagtacattt atagatgggg taaaaagcag aggtgagcct tggtattatg gatagtcaac
     1381 gtgtgtgttt gggaaatcac cgttccctta acggcggcat tgatgggaac aagaaagtaa
     1441 aaggtgtcaa gtgtcatgtg gtggtggata aaaatggctt tctacttgct gtcatggtga
     1501 cgattgcttg tgtacataat agtaagttgt ttatttactg gtaaggtatc tgagggaaaa
     1561 tatcaaagta atattggctg acgccggata ctgtggagaa ataacccaga agatcaaaga
     1621 tgtttttgga gatatcatag aagttatcgt taatgatgat aaggtaaaaa gtggattgta
     1681 gaaagaacct tttcatgcgt aaataaattg tactctccat tgtaaagaga gcagtttcta
     1741 accattaata aattgattcg tacagtctgg acaaaacaca agaaagatac aaatgcgctt
     1801 ggctattatc tttcggcatt ttgttgtttt acaacagcta agaaagaaaa gtttcataca
     1861 cacgttaaag gactcgcagc tttgatcgct tagctgttga gattagtttt atgtacgacc
     1921 tctggctgtt ttttacgaca gcaagccagt gaaagttacc cttttgtatg cttctgactt
     1981 gccttcgggg gattgaaata tcatcgcggc tgatttttac tttatagcag agtacttcca
     2041 gttccttctt taaatatttt tttcttttct tttctgttct atccttgggg tgagatattc
     2101 cgcctcgagt tccttgtact cacaggtgtt attaagtata tgtcatgccg atttcagtat
     2161 cgagtgccct actactatca aagccctttt cttaccccct gtggactgcc aaccggtgat
     2221 ggcgtgcact gtaaaaggta ttcttggtac ggattactgc ccaggcagtc tctgtaatga
     2281 tggctttcaa ctgttcgttt ttatgtgtga ttgttttact tttttacctg cgatttcatt
     2341 attccccgga cacatactac cccactaagt cagatgcttt ttccgtaggg aaggcttcca
     2401 tatcgacacc tatttctgct atcaggtctt ctactgtttt tctgctaagt ccgggggata
     2461 aaagtttaag cacattctca taaggggaaa gaacgacctt aatgcgggat gtcaggtcta
     2521 caatgatagc ttctgtctgt tcaatatcct ttcggatggt ttgcaatata taagcatgat
     2581 gcggttttat aaaactttca cacgcctgat aaagtagttt cggatcgact tcaagttttt
     2641 gtgatacatg caggttatgt cgtttctttt tacgtgtcct ttctttatca gtatgtttat
     2701 taactaggtt gccactacgc tgtccaaatg actcatggtg ttggatagtt tgatgttgca
     2761 gtcttccaaa atatcacgat acggtttttc tcggaggtta tatgttatat tagcttgttg
     2821 cggtaacggg ttaggtcacg aagttcatgc tgttcgcgtt ctagtatgta acttggtttc
     2881 aacagacctg tcaaaagctg cttacagatc catgcgctgt ctctcttatc cgtcttatga
     2941 ccgggcacat atttgatatg gtgggtgttc acaatccaga ctttcatact gagacattca
     3001 agaatcttat aggcaggttt ccagtaaaca ccggtacttt cactgttaca tgggtaatgc
     3061 cattggataa taactattct tttaatccca tcaaagaact actgaaggtt ttctagctgc
     3121 gggttccagt tttgagatct ttgccactta tcgtggttat catacgtcct tgtggatatc
     3181 tattccacaa cctcggagaa tcacttgctt aaaagctact gtattcatgt attctatctg
     3241 ttggtaaatg cttctaaggt agttaatatt caccaattta catccttttg gacaaaattt
     3301 attttatggg tgtttcatgc tttgacagct atagaaggct ttttccgaaa ttatgaatta
     3361 atatgtgatt cggcagagga aatggtaaaa ctaacatcta ttaagatgct attggataaa
     3421 atttaaacag gcttttataa atattgaata ttttacgtta ctcattagac ataatctact
     3481 ctattgtcag aatcatattc tttaggtata ttatcaattc ggcaaagaag attgaactgc
     3541 ttttttagat tattgtatca caatacttat gcaacttatt ggaaatttta ttcgcaagta
     3601 gtgcatagct taattactat caaccaaaaa tttataatat ataatacaat cttgataata
     3661 ttacaatggc ttattaatcg atatacataa gtctaaaatt attgttaatt tctgttttgt
     3721 attattcgta agtttctaat tgtattgctt tatgtgcttt aagtaattcg cattgtaata
     3781 tttgtaaaaa tgatatatgt aaacaaaatg ataagttgac atcgttaaaa ttgaatctgt
     3841 ttaaacctta gacgttgttg actaataaat tatatgtgct ttgagtatat ttttttttta
     3901 atctaaagaa aggttaattg tcccgctgta ttatagggta ctggtttttc aatatatgat
     3961 attgataatt aagtaaataa tatccttttg tttgattgtt agaaaatgca attattgtta
     4021 aatatagatt tatattaaaa aatattaaaa atattgtgtt tttgtattat ttgttgctat
     4081 atttatagca aataaaatac agacaataag agttctcctc aactctattg cccgttttga
     4141 agtgaggata aaatttttag aagtatgaaa aaactaaaat taaaaaaaaa tcacgcttgc
     4201 tgaaatgccg tctgaagcta tggataaagt aaatggtgga aacaacgaag taaaaagtgc
     4261 tcctataaca acgatttctc tgatatctct ttacacttat tcaattattg catcagcatg
     4321 tgatgattgt gcttcatatg gctgtaatac gaggtattgt caacaagaat ctaaagcgtc
     4381 ttattgctta tgtacaggtt aacaaattga taaatttgtt atgtctaata atcatgagta
     4441 gtcagaagct cataaattaa gtttctggcg gaggatatat tttacatatt attgtttagt
     4501 tgtgacgcta aattattatg taaaaagaga gagattctac taaatatgga gggtgtatcg
     4561 atcccccaaa aaaagattag ataattaatt acttcaaaag agttcggtgt tatacggaac
     4621 tctttttttt accgtggttt attttgctgc tataacaata tatgttatgg ttcagttgtg
     4681 aaatttagag ggtttagtta aaatgcttat tttgtggcat taaaccaaaa ctgacactcc
     4741 ccataaactt tttatgtaca tctacattcc aaaggttttt tctagagatt gaggttcaaa
     4801 cattctctat ttctaggaag gctacgtacc tgtgcatgca gtgttgtcgc tgggaagatc
     4861 ttgtcacagg cagatatacc tgcaactggg gaatctagtt gcctctggta ctcgcatttt
     4921 gtacggataa aatgtggcat gcgtccagct tgctcagtga tatgaaatcg agggatatag
     4981 atgcggcaca ctttgccgct gtgacaaatc ccgtgaagaa tcattacaag aggatgttgg
     5041 actactttgt gaactgtagt gccaatgcag cagcggaaat atttaacgta aaaattaaag
     5101 ctttcagagg agcagtgata aaaatacggt tgaatttgtt gtggctctta aactacttat
     5161 tttcaatcat gtatttttct tgttgcaaca caactatctt agtgtctttc tgccgatgat
     5221 gtttgttcct attccgcttt tcccaatatt gtcatgatga atgaatagtt tcctgtgcag
     5281 aagcttttta tgaagtaata cttaaggcaa cttaatattg atagcctgag atttagagaa
     5341 taatacgagt taaagcttgt gtctcaaatt tttcttgtat actagatcga taaattcgtg
     5401 agaattatgt agatgggttt tatatacttc ttccatcgta atctgaaaat aaaaggagca
     5461 tactgtaaat gtggttatct agacttcttt tattagtatt tataaagttc tcaaaattgt
     5521 aaaattagat aaagatagat ttgttttttc ttagctgtga taatggaagg ttaaaagagt
     5581 aaatgagtta aaaaaataaa taagattaga atgcttgaat tatgttggtg tcccaataga
     5641 gtagatacag tagcgaaaga cttaagagac tatttcaagc agtttgttga cgaggatgac
     5701 gtttctcatt gttttgcaaa taaaatcaat gagatgccct tggaactcca atgatttaaa
     5761 acccattatg tgacatttct cactctgagt gcgttgcagc gcaaaatgct actgatgatt
     5821 tatcttaacg taagaaaaag aaataagaat ttgaataaat actaaattta attaggaatc
     5881 tgttggatat ttgaaccttg atgtggcgtt ttgtgaaaat actataaata tagtaactct
     5941 ctaaagtacc ttttatttat gaaatttatt aaatggggag cgctgatgaa gaaaaaaagc
     6001 atggcttagg gactttcatg cttcaggttt tctaggactt ctaatatatg agtccgctaa
     6061 aaaaaacggg tggtttattt cttattgatt ttttaattat ttcaatgtta attagatatt
     6121 acatgtttga aagcttattc gtacatttat gttgtaaaaa tgtatagaaa tgttcaagga
     6181 agcagaccat aatcgccagc ttgatatatt caacgacaag tcgttgaata tgtgcaaatg
     6241 tgcacatcca tgatatctca gacccagatc tttggcacaa catgttttat attttgatca
     6301 cctcaaagat tgacaagatc gtatacaaag ccgaatgcgg atgcagtgat gccgagctgg
     6361 aaaacaagtg tgatttcgcc gtgcattgag attgtttgaa ataggcgatg cagtcccaca
     6421 tattatatgg tttgctattg tttggttgta tgcgcaaaaa aaaaggtgac ttgttagcga
     6481 aatgttttgc tcaactgagc tcacttcaag cagtcaggtt caacatttca gaaaagtccg
     6541 tgtatggaca gtaggcttat tggtagtaac attgcttggt attcacgtta tcagcttgtc
     6601 tacgagacat ttctcaagtg catcaacgaa gatacaacca accctttccc ttcaaagttg
     6661 aaagagaaag tgcttgtgct gcttcataag aacgcaaaga gtgtaatcta tacttccgtt
     6721 caggacacca tcgctgccaa acttcaaaac atcgaggctg gttatttcca gagataattg
     6781 ctgaacggga gtttatcgtc acccttctct atcgtgtcgt gtgttttgag gtcgtaaaaa
     6841 agaaagatga agaaggcgat gatacagatg aaggcaatct gcttccacgt gacaaacatt
     6901 taattagtgc tctcagtgtc caaaattcta atgatttcga agcggactac cgcaagaaga
     6961 atgactaaaa agtaaaaggc tacagtgcca acatcaccga gaagacagaa gaaggcaagt
     7021 cttctatcat tacaagcata cagatagagc ctgcaacaac gactgacaat tcatatgtga
     7081 ctgatgccac tatcgctacc gaaagtgtca cgggcaatag tgtgcaaaca ctatatgcgg
     7141 atggcgtata cggagaaacg aacagggctt ttgttaaaaa gcatggtatg gactttataa
     7201 caaccggagt gcagggtaaa accggccgct ttgattttga aatgacaggt aaggcccttc
     7261 aagttacgaa taagaaaacc ggggaagtta ttccggtgga aaagcaagaa gggaagtaga
     7321 agatacgcat taattgaaat acaccgctaa gatatttttc tgaagagtac acgcagggga
     7381 ttaccgagaa aaaatggcgg caatagattt ctaaagaaga acttaacaaa agaaataatg
     7441 tgggaacaag tattttcagt actgcttcca tgctcgcaat aacaagacat gttaccgtaa
     7501 tcttacaaag catcgtatgc atatatatgc ccgttgcatg tgaatgaatc ttgtgaggct
     7561 gacaatcttc caaattgcaa tacttcaaag aactatttgt actcttatag gctttctttt
     7621 aacatttaat atttccttat ctcacgaaaa atatctattt ttgtcatata ataatctcta
     7681 aaaaggatgc tatgtctcca caccttattg gggtgaaaaa attggatgtt tttatcgatt
     7741 attatttaat gtcgaattag tttataattt cattttatga aaaatacttt tatattatta
     7801 ctatatgttt gtatctctct tggagcaaac gctcaattgt tatggcaaat ttctggtaat
     7861 ggactaacta aaccttccta tgtgtttggt acacatcatt tatcacctct ttctatttta
     7921 gatagcatta tcggttttaa acaggttatg aatgatgttg aacaagtata tggtgagttg
     7981 gtaatggatg acatgaagat ccctattaat atgcaaaaag tacaacaagc tactctgctt
     8041 ccaggtgata ctacgctaca gactttgatg actgaagcac aatatgatag catagctcta
     8101 aaaataaaac aattaatggg agttgaacta aaaatgatga ataagttaaa gccagcagct
     8161 ctgacatcac agatagctgt tatattagca atgaaatcta tgaacaattt taatccccag
     8221 caacaacttg atggatggat tcaaacagaa gctcgaaaac aaggtaaaaa ggtttatgga
     8281 ttggaaacta tagatattca gataaaggtt ttatttaatt ctcagagttt acagcgtcag
     8341 gcagaacagc tattttgtac tttgatgcat ttagatttat tagatcaaat gtatcaaaaa
     8401 atgacaatcg cttatctcaa tcaagatata gatttgatag aaaaaataat gaaagaaaaa
     8461 atggataatg cgtgcgattt ctttcctgag gaagaagagg aattaaatta tggacgcaat
     8521 gctaattggg ttaaacttat gccgccgata atgaaagaaa aatcaactct atttactgta
     8581 gggagtggtc atttgcctgg taaactaggt gtattaaaca tgctgggtaa acaaggatat
     8641 acgattaagc cagtaaaata attgatagta tatttgttgg caagattaat acatatgagt
     8701 ttgtttttta tgttaaaaca atatcctaat ggttaaaaaa tgaaactttg atgtaaagtt
     8761 ggggaattac aagttagagt ttttatacgt tttattataa tttacactaa aagtattggc
     8821 tttcctgcct ttctgagtaa agtatcgtaa atgtttaatc aggggacacc ggtattgtga
     8881 cggggactat aatttggcgt gaactgtttt tttgtaggta tcgcagttat atttctgttt
     8941 taagttgtct cttctttatg ctgttttttt atacgcatgt aagtcataat aaggttagtt
     9001 ttgaaatatc tgtttctttc atctatcgta tctaggtgtt tctcgtatcc ttgcagtttg
     9061 ggcaagtgct tctcattgat tttttatttg atgaagttca gattgactgt ggtttactaa
     9121 gctaatgtca tctgtttttg cttccaaagt atgtcggtca atttttcgaa atattgttgt
     9181 catagaaaac gccttcatta acatgaggag gtatacatta ttttttttgc taccttttgt
     9241 gtttttttat acttttcgtc ggacaaaggt atagtgacag ctgctgagtt catcttgatt
     9301 ccatcaatat attacttttt ccagttgcta tgccctaatt ccattagcat gggaacaatt
     9361 ggagtaaacg ggctgtgaat actgttcttc aaatgcttgt tatggagact gaggcttaat
     9421 ggtacggaag ttggaatgga cttgcccgaa agctcacatg taaaggatgt tttcctgaag
     9481 tgggcgtacc attttacgac aagagtacat attattaata tgcacttgta ttctccattg
     9541 attggttcgg cccgcggtat ttcttcatgt tgcaggctaa ttggtcaagt tcaggataaa
     9601 caccatattt atgttttaaa acttttccta aggtatcaat tatacagagg aaaatactat
     9661 ctttgtatac attaagtctt gtggttattt attgggttta ttcatatgag gattattaaa
     9721 gtttgaaatt aaatgttttg tatcttgagc atggtaatag gttctgtagg atttgattgg
     9781 tctattgtat tagcctaaaa atttagtttg cagtagataa gattgtttct ttaaatttgt
     9841 tttaatgaaa tgttatatta atattttatg aaacgagctg ttttaacaat taaattctat
     9901 aagtaaatga atatacatag tttgagaaat aacactatat ctatttaaat tataatttgt
     9961 tacatggggg acttaatctt taatttaata tatattattt atggataatt ctttttattt
    10021 agaggatgcg gaaattatca aacagctatt tttgaaatca ccacatctcc aatcaaatag
    10081 tctttataaa gggaaaatgg gtattgtttt gttcctttac gaatttgcaa atcttactca
    10141 aaatgatgct ttcaagaggt ttgcttcttt tttattagat ttattgtggg aagatataga
    10201 gatggattct cctataaatt tagcattagg gctttcaggg ataggagttg gtatcgagct
    10261 tttatcacaa cgaaaattta ttgattgtaa caatacgtct gagttatgtt ttgaattgaa
    10321 taatcaaata atgactcaaa atatatatcg actaactgac tatacatttg aaactgggtt
    10381 aagtggtata atatattatg tacttataca tatcaaaaat aataggcatc attcatttga
    10441 taaagttttt ctctctgaaa tatttgaaaa atgcatacag atagatcaag cgaagctaaa
    10501 tgaaattagc aaattttata tatcatatta tcttgattat ttcaaaggtg agaaaaataa
    10561 taatcttaat cctcaattaa gtcattttat aaataagaag tctgtcaaaa atcttaagtc
    10621 aatggatgat atggggcttt atgaaggtat tgtaggttat ttatatttga aatatttttt
    10681 atgaacaaac actattatgc taaatagtgt ctttatgatt tttttttttt ttttgtatat
    10741 gttcttgatt attatcgtgt taaatatttg aatatgaaac aacatatttt tattataaat
    10801 gaaaagaatt tagcatcaag ttatggagta ggcacttaca taaacgaata tattaaatgt
    10861 ttgcgcaggt ttgatttgga gattcattta gttacattgt tttgtgatga agaattatat
    10921 aacttatatg agaatgaatt tgttgactat attaatatac ccacaactat attgaaaaat
    10981 acaaaatatt accatcaaag tgtctgtgca ataataaaat tatattatgc taaaatagaa
    11041 aagccgcttt ttcatctgaa ttttcatcaa aatatttttt ttgtcaaata cattaaagat
    11101 tactttaatg atgcaattat cttatataca atccattact cgtgttggag cttacaatta
    11161 aattcagacg ttaatttgtt taaatcgatt ttatctaaat acaatagtaa tggaaatttg
    11221 tcggagttag agcatcgtgt tatattagaa tttgaaaaag aaaaagaatt atttaataag
    11281 gtagatagga ttatttgcct ttctaatgag acatatgaaa ttttgaaaag tgaatattta
    11341 attagtccaa caaaaattaa tttaattcct aatgggattg aagattcata cactccgctt
    11401 ttaggcaatc aaaaaaatat tattagaaag tattttcata ttaaaaaaaa agaaaagata
    11461 attctttttg tgggaaggct tactgcttta aaaggagcat atatattatt agatagtttc
    11521 aagaaaatat ctccttatca tacaaactat agattattta taattggcga tggcgatttt
    11581 aatttattac taaatcaagc agagccttat tgggacagaa taacctttac aggtaaaata
    11641 gataaagaga aattaaatca actatataaa attgcagata ttggaattat accatcttat
    11701 tgtgaacaat gtagttatgt ctgtctagaa atgatgatga atgcgatacc ttgtatcgtc
    11761 tctgatggaa ttggtttaaa ttcaattttc aaaaataaca ttaacagtat tgttgctaaa
    11821 attgtcgatt atcaaaaccc cgattcatat attcttaatc ttgagaaatc aattttagat
    11881 atgattaata atgccagtaa aaaggataat atatcaaaaa aatcaagatt aacatatcta
    11941 gaaaaattta ctttggatca tatgtttgag aactataaaa aattatttct tacatttaat
    12001 ataagagtaa aagagtggta ataatagagt gtttgttata aattattctt cgaataagct
    12061 cccaagtagt gttgaagaat ttatatagtg gatgtgagat tatggtggtt gtaatggttt
    12121 aaactgtcgt ttaagacaat ggtctatttt taaaagagta agtcagatgc tttttatgtg
    12181 taagcattca gtaatcccat attgcaacat ctaaaatatt gtaagcatcc gataaagtac
    12241 acattgtaaa gtcaagaact cctctgttgc tttgcatgta aaaaagacga tgaaacgtac
    12301 aatgagtaaa agagttatga aaaaaacagt ccagtgcctt ggccataagg atttctgtga
    12361 gaatgaagcc tattcagtat cttgtttcca ttattggaag tagaagtttg gtttgagctg
    12421 tgcttatacc agccattcag ataaagctcc caatgatata tattccttta gacctgggtc
    12481 acagtagtcg tctctcataa gttgtaatta ccgaagtaat catagaattt ttttccggta
    12541 ttagaatcca ctttgacagt cacggagctg tagaaaatac agcgattgtt cattgcttgc
    12601 cacctgcaag gcgcattcag ccaatccagg agaatggctg aatgatgtca taccctaact
    12661 ttcgtactag ttggagagag gagtcggcaa agaatgtgcg cgacttgctt cctgatgtct
    12721 ggaagttgaa gaaatttgat aaaaagccaa ttggagtttg atgagaattt aataagacgg
    12781 taaaaccttc tcatcaactt tgcatttgtt aacaaaaaga gttgactgtc tttatgaatc
    12841 tacaatgtgt actttataca atattcaagt acagataatt cttgaatggt acgtatcatt
    12901 ttgaatttgg cgttagtcct tgtgaaaaat tctctgattt ttcccgggta ttccatattt
    12961 cccaaggtga catccgaata tccaaaatct ttttgttccg aaataaatgg ataaatcacc
    13021 atcttgttat gaatgatttt ggataatact ccgtcggcag tatcattctc ttgaaattcg
    13081 tatgacagaa ttgtgtcaaa tgcagatgaa taaattacaa taaattgagt attccaaaac
    13141 cagtctaccc aataacgatg atatccgaca ggaacggctt gtccgaatcc tccgatacct
    13201 ccggataaaa gttcggctcc ttgcatatat gcctcctgga tttctttaaa taacagtccg
    13261 gatgaataat tctcagtaaa gaagtggtcg tcttcacaga tgacaattac atcgtcttcc
    13321 cgctctttag ccatctttat cacctttgtt atgctgttcc aaagtccaat cgtacctttg
    13381 gagtgggtgc atgcttcgac aagatgaaat tcaaattccg attttccttc aaattcacga
    13441 acgatatgtt tccttctttc ctctctttct tttatgttga tgacatatac ggggatataa
    13501 gtcccttctt ccctctcttt tatggaaata agcaagtcgt tcatgcgctt tttccaaaca
    13561 ttccaattca agcgtgtttc aaaatgcttt ctacattctc ttctgagatt ggtatacata
    13621 tctttattca tatataaatc tatgatttta tctgcatact cagatgccgg agtatcagca
    13681 gtaaataaga atccattgta cccattatgg acagcttgac ttatacctcc aacatcggta
    13741 gttagtacag gtatgccata ggcggaggct tcacaatata taatgccgaa acaatcaaac
    13801 agagtgggag caatcagata atgggattgg ctgagtattt gttcaaaaag tttttgtcct
    13861 tcagatgatg atttgtcgat ataaggataa acaacaatat ctgtatcctt tggtatttgt
    13921 gtaggtgtac ttccaataat agtcaatgtg catgggattc ctttcttttt tacagaatag
    13981 aaaatttcaa tagtcttatt tccacctttc atttcccaat ttttacctat aaaaagcaag
    14041 ttgcagacag atatgcaatc atgatcagta tactcaggga tgttgtctat attggctccg
    14101 aactctataa cgctgatttt ttcaggtgtt gcatggtaat ggttgatggc actgtttttg
    14161 gcccattcgg aagcatatac aatatgtgtt gccttttggg ttgatctttc ttccagcttt
    14221 tcggctaaat cgagttttgg ggaatctgcg attttcagat attggttgaa tagtctgcaa
    14281 gtggtatcac ctatatatac aacagggatg tctgttgtca gataggctaa aaagaaataa
    14341 tcccggcaga taatcaggtc atagtattca taatggaata aatcggttaa catctttccg
    14401 aatagttggg catatttttc tggtgaaaaa ggagggtctt ccccgaagtt ttcccggtgg
    14461 aatttgatag cttcttcata ttgctgccaa cctgtccaag ttagccgatg atctttttcc
    14521 aaatgatgat acatataata taatgttccc gaccagttgt gtatgtctct cggattcagg
    14581 gaggaaagga atgctatatt cataatggtt tcagttatgg ttttctaaat aaaaaaatat
    14641 tccggtatga tttttcagtg cttttgtcaa ctcttcctta ctttgtcggc aagtatttag
    14701 aagtactttt tgattatgcc gtgccttttt tctattatcc actcctatgt ctggttttct
    14761 ttcatggtgg agatgataaa gcgctccttt agttcttgct attggcaatt ccaaaatctc
    14821 cagtcttttt actctctcta catcttcggg gccccatccg tagaaacctt cattctcacc
    14881 tcctgtttcc aaatatttag ttttattcac aagaaaggct cctcctaccg atgggcgtcc
    14941 tatcagtcta tgtcccattc cttcgtgtaa tattgtaata tcttttctga ttgattgact
    15001 ttcctcttta tccaaaaaac ggaaattacc atcataaggg aagcttaata cacagccttt
    15061 ttgaatatag ttgatggcat ccattagctg cttttcgggt acaagtacgt cagtatccca
    15121 aatacctaca atgacatgac gtgcgtcttt taataaaata ttaagataac gtgtccgata
    15181 aaatacggtc tcataatctt gaataaagcg gtagcggatt ctttcatgtg gatggaaatg
    15241 gaaatgttgt ttttgatcgg cttccaatat atctatatag ataaaaggag tctgcaatag
    15301 atattgtagg acacaatgca gattttcttt tcgttcagta gaatcaattc tcactggtat
    15361 aacaatgctg ataggttcca ttctttactt atatactgag gttaataact ttttgtcgca
    15421 acattccaat agattttcta ttttggcatt cattatattc agtgtgtgca ataaaaccaa
    15481 aataaaataa aattcataat aatccttgtc tgtagaatta tcttgtaagg cttcagctat
    15541 ccagtcaatg agatagatag tatattcttt taagtccaat acagtcggtt cttcggaatc
    15601 ttttctatag taaagccgat gatataagta acaagctagt cctaatattc cctgttcaat
    15661 acttaaatcg aatggtgggc ggacatttat agcagcaaat actctactgt ctatttctgc
    15721 cagaatttca tctgtgtttc cttccacaaa accattttgt atcagatatt ccgttcctgc
    15781 tcctattccg cacagaccgt ctctatatgc taatgacata tctttagtac attcgttcca
    15841 tatatcatcc agcatttcct ccgcccgtat cctccattct tcttcttttg tattacggta
    15901 taatcggaac agggcaatcg tttttcccat tttgttaagc ataaactctt ttcattttag
    15961 attacataga attgcttttt ttgaacgata atacttattt aaataccaat aaattactaa
    16021 ttctacagtt ctctggttaa ttctatacat acgatttaca tgcatgtgaa ttatgctaga
    16081 aagtttatta tttttaccgg tcaagatgtt tagaggaata gttctcataa tatatatatt
    16141 tttttttatc tctttattcc accaacagtg tttactctca tcattcaaac atttctcaat
    16201 ttcatttcta tattttctat atttcaaatt taatatatgc ccaatagtac aatcagattg
    16261 atataattct aaaaaatatg ctttactatt cttttctgta aaattaattt tttcatcaag
    16321 gctaaaatta catatatcca taatcgaatc aataaacttc atcgatattt tatatctatc
    16381 ttggtctgta caatttagtc ttttaagaca cttagtaatc aaacagctgt cgtagtaaaa
    16441 aaaagtctca aaatgaacta tctcattgta ttcatacctt tccaattctc ttgtataagt
    16501 gtctaattga actttagtta tgattaaatc cttaacataa cggttaagag ttttataaat
    16561 aagatgaaga ataaatgcat aattatttat attagtgcaa tgtaatctta acctaatatg
    16621 ataattagga tccatatatc ttacaaagaa gaatgaatct atcattctct gttttataag
    16681 aagatttatc ttgcacataa tatcattaat aaaaatattt tctattgttt tcggtccaga
    16741 atatatttta aaatatatcc attctcctcc tattataaat atacgctgtg tcatttctta
    16801 tatagattta ttataagttc attagcaaaa aaaccttctt gagactcaac aagatttata
    16861 tttttagaac tatatagaaa ttcttctaaa ataattggtc tctttttctt gagctcacta
    16921 ataaaaattt taacaagatg ttctttgttg aaatttatat ataattgatt gtcccccaaa
    16981 gttattaata tttcgtctgg tattctctgt tttagtttcc aagaatacaa ttcatcgcta
    17041 tttaaatttt tattttgtgg aaattcattg ggatgaatta accatctagc tggttttagt
    17101 attacattag aatagataac tcttgggaga aatgatttat tatgaaaata tgatccccaa
    17161 tcaaaagagt aagacatgga ttcttgattt atataatctg ataaaaagct atatattgga
    17221 agcccatttt ttgtattatg tgcagttgat aacattggaa taattctttt cttattcttt
    17281 tttgatttca atataacttc ttgtccatgg tacactgaaa tggttatatc atcaattggt
    17341 atgatcttct ttacatactt agtggttgga ctagataaat agcaaattcc atattgtcta
    17401 ttattaggat gcatttgaat atttccaatt ctatcctctg gaagatgcat tacctcagcg
    17461 actatgcaat ctttataata taattcatca cgtttattta tttcatttac aaaattttca
    17521 attttagaat ctaaatattc aaatcttgaa atcaatctag aagtagcacc cccaattatc
    17581 ccttttaata aaatagatgg cgtatcatca tttgataaaa cagagagcat gactgaacac
    17641 tgaggaagtt ttaagtcacg ttcttcgaat tcatttaaat cttcatctag tatttcaatc
    17701 tcatgcaatc cttgttttat agcctcttca tactttttta ttagcaacat cgtgactgga
    17761 gtcagatcca tatcgatctt ataagatcgg tctaaaaaag gattgggcaa cccttgtaat
    17821 aaaggattta tatcgccatt gttctcagtc cagtttccat aaccaattcc tacttgtggg
    17881 tctaatgcta caactagtgg tacttcctgc tcttcatact tttcataaaa tctcctctta
    17941 aaaagctcaa aagtctcaga tttatggctt ggctgaaatt ttgaaaagaa gtatatgcat
    18001 ttatcaataa ctttagtaat gttatttcct attatgcctt gtttaacttt atttaaagta
    18061 tctacttgca ttagagtatc ttgctcaaat aacataccat ccgataataa acggtatata
    18121 ttattaataa tcgattcttt atttcctagt gattccttgt cacattcttt taataaatat
    18181 atgagagaat taatgaattc tagattataa ttaatttctg aaagattatg atgcaattgt
    18241 tgaatcaaat cttcgccaac cacagatggc tccaaattac taattaagat ttgttcatca
    18301 ataagtgtct gaacaaaatt taaagcttct tcctcttcta tttctttatt ttttatcaat
    18361 agcctaatta tttccttttt tgttaaaggg gtcttcttta atgcttttat tatattgttt
    18421 aaatatggtg tatgagaaat ttcagagaag gtataattcc gtttagattt attgatgcga
    18481 tactcaatat agcgcaaatt tttacctaaa aaatacgaag ttgtatttac atgatatgta
    18541 attgcattct gtatctgtgg cattaaatct aactttctta taagttcaca taaatagttc
    18601 atatctatac gtgtatatgt cttataattt ttaaggtctg acataattat gttagaataa
    18661 ttatcatcaa ttctaatagg tactatatca caacccgcaa aaataccgta tggtgtacat
    18721 cttgtacaac tacggacata atattttata gcggaattta tagtcctttc atttatatta
    18781 ttttttatat ataattcttg gtagagaaca ggagttgcaa tataaactgc ttctttaaat
    18841 gattgctgaa atattgataa ctcaaagtct tctattttat caatgtaatt aataggaaat
    18901 aacggtgttc taataatgca ttgattataa ggaatatatt tattc
//
