LOCUS       c00275_gnlPro..        16319 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EFPKBAIN_279.
ACCESSION   c00275_gnlPro..
VERSION     c00275_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 13:41:59
            Original ID  :: gnl|Prokka|EFPKBAIN_279
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16319
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16319
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4356:7905](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4357..7905
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16319
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16319
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             214..1770
                     /locus_tag="ctg275_1"
                     /transl_table=11
                     /translation="MNDLLRKLPIGIQTFEKLRKGDYLYVDKTELVWKIAYTSTPYFLS
                     RPRRFGKSLLLSTFEAYFEGKKELFEGLAIEKLETKWEKHPVLHLDLNAEKYDSPERLY
                     DILSRQLTLWEIQYGKGIDENTLSGRFSGVIRRAYEQTGSSVVVLVDEYDKPLLQALGN
                     DVLLDEYRKTLKAFYGVLKSADRYLRFVFLTGVTKFSQVSVFSDLNQLQDITLWPDYGT
                     LCGITLQELLDTFQPEIKILAANNSISYDDAVQRMTRLYDGYHFCINSVGIFNPFSVLN
                     VLKSKVFDNYWFQTGTPTFLVEMLQETEYDLRTLLDGIEAPSSMFSEYRVDSNNPIPLI
                     YQSGYLTIKDFDREFGNYLLQFPNDEVRYGFINFLVPFYTGVRNSDQGFYIGKFVQELR
                     SGDYDAFLTRLQAFFADFTYELNEQTERHYQVVFYIVFKLMGQFTDAEVRSARGRADAV
                     VKTPKYIYVFEFKLHDTAEAALKQIDDKGYLIPYQADGREVIKIGVEFSAEKRNISRWL
                     V"
     CDS             complement(1781..2983)
                     /locus_tag="ctg275_2"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARRMASELALLPMWYV
                     EEGSAVLASSAYNLGYVKKIQELLGLSVDLMTEPELAIEPNLDIRPWGWDVALRKRLSG
                     LGVDEALLPSMEQLNGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQEEWKTFVEER
                     ECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNKVEDFAMEFYS
                     DGTGEVTFMGYSLFHTGKSGMYEGNRLLSNEAIWKQLSQYVPSKVLTDLENCLKYRLSA
                     LVGTVYKGYLGVDMMICRFPENEKPVFRIHPCVEINLRMNMGVVARFLYDRYVRSGSTG
                     RFVIDYHPSEGEALQEHERMSATYPLEIREGRVYSGYLPLVPVHRRSCYRAWIWVTPDN
                     I"
     CDS             3146..4324
                     /locus_tag="ctg275_3"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             4357..7905
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg275_4"
                     /sec_met_domain="PFOR_II (E-value: 6.1e-19, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 6.3e-32, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.9e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.9e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.5e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVETNKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(7866..8015)
                     /locus_tag="ctg275_5"
                     /transl_table=11
                     /translation="MNSSGKKVVLFMLDRVHTIKNGNLLQDYRFLFIGYYYYSAPQFSL
                     AKRL"
     CDS             complement(8057..8929)
                     /locus_tag="ctg275_6"
                     /transl_table=11
                     /translation="MHVRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAM
                     SHLAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEF
                     LGEVYGEARVGLVVPQYVTIQSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGL
                     DGYTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEI
                     HAIAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVD
                     SWIPKSENK"
     CDS             complement(8947..9771)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.5; E-value: 8.7e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg275_7"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.5e-29, bitscore:
                     92.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(9768..10994)
                     /locus_tag="ctg275_8"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEERAKKAMESMMLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(11294..11632)
                     /locus_tag="ctg275_9"
                     /transl_table=11
                     /translation="MKDYKVDKASLFASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CFRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             11716..13104
                     /locus_tag="ctg275_10"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGV
                     FAFSSCEKNLYDESKQPEKEIQVKDLNIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEA
                     CSKEEKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNETKKVAIPVNADRSFSLNIA
                     NDAKSKSNTTRSITRGHDIEDDIQLAKGVIFHPKDGWGTIMFEDQFPSLGDYDFNDFVV
                     NYKVQFQGIKKVDKKYTAQYMQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETK
                     NVIPAIDGVDLVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITL
                     KKRKEVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDD
                     NYYFSAGRLIWGLRVPGNAAHAIEKANFLEAYKGFAKWAQSSGKNEQNWYNQGNADKSL
                     LIHN"
     CDS             complement(13185..16022)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.8e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg275_11"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.9e-20, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRMMGYTKWIAVLLCLLGMTACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMN
                     ILEKKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQVDVLSSFEGWNESFLAAARKKH
                     IHFFFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIR
                     FTVANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQG
                     TVFTVDLPVQTCETILAEDSLKSSISAVPLNPASPGSPASSNLNETLAVEEEELEKGYD
                     SSKPSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGI
                     DGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRN
                     LIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGLS
                     RVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYR
                     EQFGESPTDLLKRKG"
ORIGIN
        1 aggattacgc attaaaatta gggtcacaac cgtaagtcat aaaacaaatt cacctctgtg
       61 tcctccgtgt cctctgtggt gaaaaccgtg caagaatgag ctaaatgata attttccagt
      121 taaacaaaat tataacgccc gttctttgag atattgaaaa cgaaatatta cgaaaataat
      181 gattatcttt gaaccactaa aaggaaaata acaatgaatg acctgcttcg taaactccct
      241 atcgggatac agacctttga gaaacttcgt aagggcgatt atctatatgt agataaaaca
      301 gagcttgtat ggaaaatagc ttatacatct actccatact tcctgagtcg tccacgccgt
      361 tttggtaaaa gtcttcttct ctctaccttt gaagcctact ttgaaggaaa gaaagaactc
      421 ttcgaagggc ttgccattga aaaactggaa acgaaatggg aaaagcatcc tgtgctgcat
      481 ctggatttaa atgccgagaa gtacgattcc ccagaaagac tttatgatat cctcagccgt
      541 caactcacct tatgggaaat ccaatatggc aaaggaatag acgagaacac tctttccggt
      601 cgtttctccg gcgtcatccg tcgtgcctac gaacaaaccg gtagcagcgt cgtagttctg
      661 gtagacgaat acgacaaacc tctattgcaa gctttaggca atgatgtctt actggatgaa
      721 taccgtaaaa ctctgaaagc cttttacgga gtattgaaaa gtgccgaccg ctacctacgt
      781 ttcgtcttcc tcacaggagt aacgaaattc tcacaagtaa gtgtattcag tgacctcaac
      841 caattgcagg acatcacttt atggcccgat tacggaaccc tttgcggcat cactcttcaa
      901 gaattattgg ataccttcca gccggaaatc aagatactgg cagccaataa ttccatttct
      961 tatgatgacg cggtacaacg aatgacacgt ctctacgatg gctatcattt ttgcattaat
     1021 tcagtaggta tcttcaaccc gttcagtgta ctgaatgtcc tgaaatcaaa agtgttcgac
     1081 aattactggt tccagaccgg cacaccgact ttcctcgtcg agatgctgca agaaaccgaa
     1141 tacgacctgc gtactttgct tgacgggatc gaagcaccgt cttccatgtt ctccgaatat
     1201 cgtgtagatt ccaataatcc gattccgtta atttaccaaa gtggctatct gacgataaaa
     1261 gatttcgata gggaatttgg taactatcta ttgcaatttc ctaatgatga agtccgctac
     1321 ggcttcatta atttcctggt tccattttac accggagtga gaaacagtga ccaaggattt
     1381 tacatcggca agtttgtaca agaacttcgt tcgggagact acgatgcctt tcttacccgc
     1441 ctgcaagcct tctttgccga tttcacctac gaattgaacg agcagacaga gcgtcactac
     1501 caagtagttt tctatattgt cttcaaactt atgggacagt tcaccgatgc cgaagtacgc
     1561 agcgcccgcg gtcgtgcaga tgccgtagtg aaaacaccta aatatatcta tgtcttcgaa
     1621 ttcaagctgc atgacacagc agaagcggca ttgaagcaga tcgacgataa aggctatctg
     1681 ataccgtatc aggcagacgg acgtgaagtg ataaagatcg gggtagagtt cagtgcggaa
     1741 aaacgcaata tcagtcgctg gctggtgtga acagataaag ttaaatatta tcaggagtta
     1801 cccatatcca tgcgcgatag caacttctcc tatgaacagg aaccaaaggt aaataaccgg
     1861 agtacactct accttccctg atttccaacg gataagttgc ggacattcgt tcatgttcct
     1921 gcaaggcttc accttccgaa ggatgataat caatcacaaa acgccctgtt gaaccagaac
     1981 gtacataacg gtcatataaa aaacgcgcaa caactcccat attcatgcgc agattaattt
     2041 ccacacaggg atgaatccga aaaaccggct tttcattttc cggaaaccga caaatcatca
     2101 tatcaacccc aagataacct ttataaacgg ttcctaccaa cgcagaaagt ctatatttca
     2161 aacagttctc caaatccgtc agaacctttg aagggacata ttgcgaaagt tgtttccaga
     2221 ttgcctcatt agaaagcaaa cgattccctt catacattcc actctttccg gtatggaaga
     2281 gggaatatcc cataaatgtc acttcacctg taccatcgga ataaaactcc atggcaaagt
     2341 cttctacctt attatatata ggttccgcaa tgattccacc ctgcgaagca gccacacgcg
     2401 tacaccaacc ggatataaaa ggagtaaata tgcctttaca ccagttcaag cctttaccgc
     2461 ttcccgaaag cggagctttc aacaggcagc attcccgctc ttccacaaag gttttccatt
     2521 cttcttgtgt cttcaaataa taagattctc cgcagaaata ttcattcagt tgtaattccg
     2581 gaagcaatga gacggcttta gaacgatggg agtattcccg cagaccgttt aattgctcca
     2641 tagaaggcaa cagggcttca tccacgccca gccctgaaag ccgtttccgc aaagctacat
     2701 cccaccccca aggacgaata tccaaattcg gttcaatagc aagttccggc tctgtcatca
     2761 aatcaaccga aagtcctaat aattcctgta tcttcttcac atagccgaga ttataggcgg
     2821 aagaagctaa tacagcactc ccctcctcta cataccacat cggaagcaaa gccaactcgg
     2881 aagccatacg tctggccgaa gccggagcca tatagttcgt ttcaccgcta gccaacgcca
     2941 agtcatgttc cggattgaat atataaagag ccttttttgt catttcaaat gaattcaaaa
     3001 ctttattctg caaatatata caggaaatag tcaggaatga ctacaataaa cagaaagttg
     3061 gaattaaaca cacaattttg ccatctctac tttgcaaatc ctaaaaaaag cagtatattt
     3121 gccacccgaa aaacaaagaa ctgaaatgga atcattctac cgcacacacg cctacctcgt
     3181 tgagcacacc aatgcccccg ttcgccgcga tcttatggac gagatcgact ggagcgaccg
     3241 cctgattggt atcaaaggga cacgtggcgt aggaaaaacc actttccttc tccaatacgc
     3301 caaagagaaa ttcgggaacg accgttcctg tctgttcatc aacatgaaca acttctattt
     3361 ctcgggccac agcattgtag acttcgccaa cgaatttcag aaacgtggcg gaaaagtatt
     3421 gttgatcgac caggtgttca aacatccgga atggagcaaa gagttacgca tgtgttacga
     3481 ccgttttcct aacctgaaaa ttgtcttcac cggctcgtcc gtgatgcgac tgaaagaaga
     3541 aaatcttgaa ttacgtgata tcgccaagag ctataacctg cgtggattct ctttccgtga
     3601 attcctaaac ttgcaaacag gcatgaaatt cagggcatat agcctcgaag aaattcttag
     3661 cactcacgaa cagattgcca aaggagtact ctccaaagtc cgtccgttgg attattttca
     3721 ggattatctg caccacggat tctatccgtt cttccttgaa aaacgtaact tttcggagaa
     3781 tctgctgaaa acgatgaaca tgatggtgga agtagatata cttctcatca aacaaattga
     3841 actgaaatat ctttcaaaga taaaaaaatt gctatatttg ctcgctgtcg acgggccgaa
     3901 agctccaaat gtgagccaac tggcaagcga catacagaca tctcgcgcca cggtgatgaa
     3961 ctatatcaag tatctggcag atgcgcgact cattaatctg gtttatccga aaggggaaga
     4021 attccctaaa aaaccttcaa agataatgat gcacaactcc aacctgatgt attccatcta
     4081 tccggtgaaa gtggaagagc aggatgtgct cgacacattc tttgcaaatt ctttatggaa
     4141 agaccataag gtacataaag gagataaaaa cgtctctttt atggtagacg aagtaatgcc
     4201 gttcaaaatt tgccaggaag gcgcaaagat caagaacaat ccgaatgtaa cgtacgcgtt
     4261 gcataaggct gaaataggtc ggggcaacca gatacctctc tggatgttcg gctttttata
     4321 ttaaaagatt tatttactta aatatttaat ttagttatga ctaaacagaa gaaattcatc
     4381 acttgtgatg gtaaccaagc tgcagcgcat atctcgtata tgttctctga agtagcagct
     4441 atctacccca tcactccttc ttcgactatg gctgagtacg tagacgaatg ggctgccgca
     4501 ggacgtaaga acatcttcgg cgaaacagta ttagtacagg aaatgcaatc tgaaggtggt
     4561 gctgccggtg cagttcacgg ttctcttcag gctggtgcgt tgactactac ttacactgct
     4621 tcccagggtc ttctcctgat gatccctaac atgtacaaaa ttgccggtga gttcttgcct
     4681 tgcgtattcc atgtgtctgc tcgtacattg gcttctcacg cattgtgtat cttcggtgac
     4741 caccaagacg taatgtcagc tcgtcagact ggctttgcta tgttggctga aggctctgta
     4801 caggaagtta tggatttggc tggtgttgct cacttggcta ccatcaaatc tcgcgttccg
     4861 ttcatgaact tcttcgatgg tttccgtaca tctcacgaaa tccaaaagat tgaaatgttg
     4921 gaaaatgatg atcttgctcc gctgatcgac caagaagctt tggctgaatt ccgtgcccgc
     4981 gcactgaacc cgatgaaacc ggtagctcgt ggtatggctg aaaatcctga ccatttcttc
     5041 caacatcgtg aatcatgcaa caactactat gaagcagttc ctgctatcgt agaagaatac
     5101 atgaatgaaa tttctaagat cacaggtcgt aaatacggtt tgttcgatta ctatggtgca
     5161 gaagatgcag aacgcgtaat tatcgctatg ggttctgtaa cagaagctgc ccgcgaagct
     5221 atcgactacc tggtagcaaa cggcgaaaaa gtgggtatgg ttgccgtaca cctatatcgt
     5281 ccgttctctg ctaaacactt cttggctgct gtacctaaga ctgctaaaac tatcgcagtt
     5341 cttgaccgta ctaaagaacc gggtgctaac ggcgaacctc tttaccttga cgttaaagac
     5401 tgcttctacg gtgcagaaaa tgctccggtt atcgttggcg gtcgctacgg tttgggttca
     5461 aaagatacta ctcctgctca aatcctttca gtattcgaaa acttggctat gccaatgccg
     5521 aagaaccact tcactatcgg tatcgtagac gacgttactt tcacttctct tcctcaaaaa
     5581 gaagaaatcg ctttaggcgg cgaaggtatg ttcgaagcta aattctacgg tttgggtgct
     5641 gacggtacag taggtgctaa caagaactct gtaaagatta tcggtgacaa cactgacaaa
     5701 cactgccagg cttacttctc ttatgactct aagaagtcgg gcggtttcac ttgttctcac
     5761 ttgcgtttcg gtgacaatcc aatccgttct acttatctgg taaatactcc gaacttcgtt
     5821 gcttgtcacg ttcaggctta cctgcacatg tacgatgtaa ctcgtggttt gcgtaagaac
     5881 ggttctttct tattaaacac aatttgggaa ggtgaagaac tggctaagaa cctgcctaac
     5941 aaggttaaga aatattttgc acagaacaac atttctgtat actatatcaa cgcaacacag
     6001 attgcactgg aaattggttt gggtaaccgt accaacacaa tccttcaatc tgcattcttc
     6061 cgtatcacag gcgttattcc tgtagaacaa gctgttgagc agatgaagaa attcatcgtt
     6121 aagtcttacg gcaagaaggg tgaagacgtt gttaacaaga actatgctgc cgttgaccgt
     6181 ggtggtgaat acaagacttt ggctgttgat cctgcttggg ctaaccttcc ggatgacgca
     6241 aaagctgaaa acaacgatcc tgcattcatc aacgaagtag ttcgtccgat caatgcacaa
     6301 gacggtgact tgttgccggt atctgcattc aagggtatcg aagacggtac ttggtatcaa
     6361 ggtactgcta aatacgaaaa acgtggtgta gctgcattcg ttcctgaatg gaatccggaa
     6421 aactgtatcc agtgtaacaa gtgtgcatac gtttgtcctc acgcttctat ccgtccgttc
     6481 gtactcgacg ctgaagagca gaagggtgct aagttcgaac aactgaaagc tgtaggtaaa
     6541 gcattcgacg gtatgacatt ccgtatccag gtggacgttc tcgactgtct gggttgcggt
     6601 aactgtgccg acatctgtcc gggtaatccg aagaagggtg gcaaagcatt gacaatgaaa
     6661 cacctcgaaa gccaattggc tcaagctgaa aactggactt actgtgctga aaacgtgaag
     6721 actaaacaac atcttgttga tatcaaggct aacgtgaaga actcacagtt cgctactccg
     6781 ttgtttgagt tctccggcgc ttgctctggt tgtggtgaaa ctccgtacgt gaaattgatt
     6841 tctcaattgt tcggtgaccg tgaaatggtt gctaacgcta ccggatgttc ttctatctac
     6901 tctggttctg ttccttctac tccgtatact acaaacgaaa acggacacgg tcctgcttgg
     6961 gctaactcac tgttcgaaga cttctgtgaa ttcggtttgg gtatggaatt ggctaacgaa
     7021 aagatgcgtg ctcgtctcgt gaaagtgatg aacgaagcta ttgctgctga ttgcactcct
     7081 gctgaagtga aagaactgtt cgctgaatgg atcaacaata tgctggatgc ggacaagact
     7141 aaggaattgg ctgctaagat cattccggtt gttgaaacta acaaggataa atgtaaccac
     7201 tgcaaacaaa tcgctgaact gcaacaatat cttgtaaaac gcagccagtg gatcattggt
     7261 ggtgacggtg cttcttacga tatcggttac ggtggtcttg accatgtaat cgcttccggt
     7321 aaggacgtta acatcctcgt tctggatact gaagtttact ctaacacagg tggtcagtct
     7381 tctaaagcta ctccggtagg tgctatcgct aagttcgcag ctgctggtaa gcgcgtacgt
     7441 aagaaagacc tcggtctgat ggctactact tacggttatg tatatgttgc acagatcgct
     7501 atgggtgctg accaagctca aactctgaaa gctatccgtg aagctgaagc atatccggga
     7561 ccatctttga ttatcgctta cgctccatgt atcaaccacg gtctgaaagc aggtatgggt
     7621 aagagccagg aagaagaaga aaaggctgtt aagtgcggtt actggcactt gtggcgttac
     7681 aacccggctc tggaagaaga aggcaagaat ccattccaat tggatagcaa agaaccgaac
     7741 tgggaagatt tccaaggttt cttgaaaggt gaagttcgtt acgcttctgt aatgaaacaa
     7801 tatcctgctg aagctgaaga actattcaaa gctgccgaag aaaacgctaa atggcgttac
     7861 aacagctaca aacgtttggc tagagaaaac tggggtgctg aataatagta ataccctata
     7921 aataaaaaac ggtaatcttg tagaagatta ccgtttttta ttgtatgaac tctgtccaac
     7981 ataaacagta ctaccttttt cccactagag ttcatgtcta ttttatattt aaaattaaga
     8041 ataacaatgc tccaatctat ttattctctg acttcggaat ccaactatcc accaacagcc
     8101 gatgctcatc cctccattta cgggctattt cttcttcatc catcctggca tccttcatag
     8161 ctgtcataaa agagctaagt tcttctgtcg ttagtttgat gttgccaaag aactcggcag
     8221 caaacggatc tttctcactg aatcctttcc atgcaatagc atgtatttct tccaagtctc
     8281 catatacttt cttcggatca tccaagaatt tcaagtcaaa ctggtcgaac atccaatgcg
     8341 gtgtccaccc cgtaatgaca atccattctc ctttgtccat cgcttttttc aaagaagcca
     8401 gcatggtgga actacttgaa gtcatgaggg tatacccatc aagtccgtaa gcagcaatgg
     8461 ccttatcggt cgtcttcatt atccctgctc ccgcatcaat tcctactatt tcagaagaaa
     8521 aacggtcttt attagcttcc agctcattaa tagactggat cgtaacatat tgaggaacaa
     8581 ccagtccgac gcgagcttct ccgtatacct cccccaaaaa ttcgatgctg tctccatact
     8641 gatccatata atctttcatc gttattggta accaggcatc cagaaacaca tctgatttct
     8701 ttcctgacat agatacaaaa ataggggcaa gatcagcatt ttgcaattca acctcatatc
     8761 catgctcttc caataccacc ttagccaaat gactcatggc aataccttcc agccaattgg
     8821 cataggctat ttttactttc tttttctcta agtctgaatt agtacaggaa gctagcaaaa
     8881 gcatagccga aagcactatt cctactattt tatatattct cacatgcatt tttattcctt
     8941 tccgttttag ttcttatttt ttcgtcctgc cattccttgt gtgatacggt ctaagatgat
     9001 agctaaaata acaacagcta taccaccttc aaacccaagt ccgattttca tttgggtaat
     9061 acctttcaat acaatttctc ccagaccacc ggcagcaatc atggcagcaa tgacaaccat
     9121 agaaagcgac atcataattg tctggttgac acctgtcagg atggttggca acgccaaagg
     9181 aagctgcact ttatacaata actgccaacg ggtagccccg aacgaacggg aagcttccac
     9241 tacattttta ggaacttgcc gaattcccaa tccggtaagg cggaccacag gaggcatagc
     9301 aaagataatg gtggcaaaca ctcccggcac tgctcccaat ccgaaaaata aaacggcagg
     9361 aatcagataa acaaaagcag gcatcgtctg catcaagtcg agaacaggac ggagtatttt
     9421 ctctgcacgc ggactgtttg ccgtccacac tcctaaaggt acaccaacaa tcagagccag
     9481 acaggtagat gaaaaaacga gagccagggt ttgcatagta gcctcccaaa atcccattcc
     9541 ataaatcagt aataatccca atgcggtgaa aattgccgta ccacgtcctg ccttcatcca
     9601 tgcgagtgca gcaagcacta gaatggttat ataaaaaggt attccaaaaa gtacgtgttg
     9661 gaatcctata ataaaactac cgatgcccgc attcacggca tcaaagaaag tggaaaaatg
     9721 taccatcatc caattgatgg ccatctctat atattgtcct atatttatca taaatctatt
     9781 gcgttttgaa ttatttcgtt tatttcttct ttatctttcc ccgtcacttc gatgattaag
     9841 gaggaaagcg ggattgttcc taaaaactca tgcgtctcat caatcaccca taccggcgaa
     9901 ttgctctttg tcattaaagg aagtatatcc tccaacactg tatcctccaa tacagaatgt
     9961 acttcggtac gcacaatcgt ttcaatggat ttttcctgtc tgctacgtaa cttaagcagg
    10021 tcgttcagac gtacttctcc gaccagttta tcatcggcgt ctatgacagg taatacggtg
    10081 atattcttcg cacgcatctt acgaatcaat acttcaggtc cctctttctt cagacgggcc
    10141 accagtggtt tgtcaatcat taaagaagaa gcggtaataa ttttactcct gtccacgttt
    10201 tcaacaaaac gggctacata atcgttagcc ggttcggtca gtatttcttc tgaagtacct
    10261 acctgcacca cctctccgtc tttcataatg gcaatacggt cgcccagttt aatcgcttca
    10321 ctcaagtcat gggtaataaa gacaattgtt tttttcatct tcgattgcaa agccaacagt
    10381 tcatcctgca tttgcacacg aatcagagga tcgagcgcag agaaagcctc atccattaga
    10441 agtacttcag gattattagc cagggcacgg gccagtccga cacgctgttg cattccaccg
    10501 gaaagctcgc ctaccatctg attttcgtat cctttcaatc cgacaagcat catgctttcc
    10561 atagctttct tcgcacgttc ctctttcttc actccctgaa gttcgagacc gaatgcaata
    10621 ttgctcaata cggaacggtg aggtaacaga ccgaaattct ggaaaaccat cgccagctct
    10681 ttccgacgaa cctgcaataa ttctttttcg gaaattttag atatatctac tccgtttaca
    10741 agcacttgcc cggtagtagg acgtatcaga cgattgatac aacgcagtaa tgtcgatttt
    10801 ccacttcccg agagtcccat tatcacgaaa aactctcctt cattaattga aagattggca
    10861 tctttcactc ctaccgtaca accggtatct ttcagaattt cctctttact cttatctttt
    10921 ttcaacatct tgagggcttt ctgcttctcg ttaccaaaga taaggtacaa atcctttatt
    10981 tctattttac tcatataata tattggttta gattataata tttgttttgt tttcaactgc
    11041 cgcattcctt attctcactt acgataaaca agttgaatgt tcgcatggtt cagtcatgtc
    11101 acatgataac atgacggtcc gacgtttttt aaatggttta aaaaaaacag acagagtagt
    11161 ttaaaaggaa tagaatttga taagattatc ctcttaatga acagtagaaa acagtatttt
    11221 cataaataaa taacagtctg ttcttgcata ttgttggcac aaaggtaagg aaaatagatt
    11281 aaatatgcaa atttcattca ggtacggagt aattccaaag atgctttttc aagtctacgc
    11341 atccattttg tttgaaagag atcccttctt ccaacaagag ttgtttctgc tctgtccaac
    11401 ccggaacaag ccgtcccgac gcattgacaa cccgatgaca aggcgcagat aaatcatccg
    11461 gaatctgttt caaagcacgc cccaccatac ggaaacattg agacattccc aataatgcgg
    11521 caattccccc ataggtagaa actttaccta ccggaatttc tcggacaacc tgatacacct
    11581 cttgacaaaa ggatgcgaaa aggctcgcct tatctacttt ataatctttc atcactcaaa
    11641 cattacttta tttcagttcc aaaactagat aaaaagaaaa gaatttgcaa ataataaaag
    11701 catttcaaat aaaatatgca actttatttg ctttatttac aaataatccc gacctttgta
    11761 cccattaaaa gcaaccctat tattaacaaa acaagcactg ctgttatgaa aaagaagaca
    11821 attctattcg cttcttgttt attgggagta ttcgctttca gctcctgtga gaagaacctt
    11881 tatgatgaaa gcaagcaacc tgaaaaagaa attcaagtaa aagacctgaa tatacccgca
    11941 ggctttcaat ggaaattaac tcaagtagcc gcaggaacag tagctgctac tacccccact
    12001 atggtttcct tctttttgga tgaagcatgt agtaaagaag agaaaatagc cgacattcct
    12061 gtagatacag aaatttcaag tctccctttg agcatcccaa cctacgtaaa tacattgtat
    12121 gcccagtaca aaaccagcac caatgaaaca aaaaaagtag ccatacctgt aaatgcagat
    12181 agaagtttct cactgaacat tgctaatgat gccaaatcca aatctaacac cacccggtca
    12241 atcactcgtg ggcatgatat agaagatgac atccaattgg caaaaggagt catttttcat
    12301 cccaaagatg gttggggaac aatcatgttt gaagaccaat tcccatcatt aggagattat
    12361 gactttaatg attttgtagt caattataag gtgcagttcc aaggcattaa aaaggttgac
    12421 aaaaaataca ctgcgcagta tatgcaaata ggattacgtc taaaagctat cggaggaata
    12481 ttcccttatt ctccttattt aagactgaaa gaaatagatt ctgacgaagt ggaaagtata
    12541 gaagtttatg aaactaaaaa cgtgattcct gcgatcgacg gagtagatct tgtccccaat
    12601 aaacatctta tcattgatta cagcccttta attaagaatc tggctaaacc tgcaggcagc
    12661 caatattata atacagaaaa gaatgctttg gtagcaacaa gtgatttacc ggagatcaat
    12721 attctgatca ccctaaaaaa gagaaaagaa gtaaaggaaa tattagaagg cgatgaattc
    12781 gacttgtatt taaaacgtaa tgatagcgga acagaaatcc atatgaatgg tattgaaccg
    12841 atcacttacc aatatccatt caatgataaa aatctgctac cggtatatac aaacggggac
    12901 gaagaagatg ataattatta ttttagtgca ggacgcctga tttggggatt aagagtacca
    12961 ggcaacgcag cgcatgctat tgaaaaagct aatttcttgg aagcctataa aggatttgca
    13021 aaatgggcgc aaagtagtgg caaaaacgaa caaaactggt ataatcaagg aaacgcagat
    13081 aaaagtttat tgattcataa ctaacacata tcaataaatc ccggtaaaca ttgaaaattc
    13141 aagttaccgg gatttattgt attctgacgt gaatagtttt gattctatcc tttccttttc
    13201 agcaaatctg tcggactttc accaaactgc tctctataac atttggtaaa ataagaagga
    13261 gaactaaaac cgacttcata accaatctcc gccactgtca tatctgacga agcaagcagg
    13321 gaagcagcct tcttcaagcg agcgatgcga agcaattcat tcggagaata attagtcagg
    13381 gattttattt tgcgatagag ttgcacacga cttaatccca tatccttacc caaatcctct
    13441 acattcaaat ttgaatctcc catctttgct tcaattaaag ccttgaattt ttccacaaag
    13501 tctttatcca tatcacagac atcctctttc gccaacgttt gtccgtcacc aaagaactgt
    13561 ttcaggcggc gatgtgaatc tatcagatta cgaacgcgtg ccaacagcaa ttgcgaactg
    13621 aagggcttgg agatataaga atccgcacct ccgtcatatc cctgaatccg ttgttcatcc
    13681 aaagaacagg ctgtcaatag gatgacaggg atatggcagg tttgcagttc gcttttcagc
    13741 cgacggcaac actctattcc atcaatacca ggcatcatca catcagagat tatcaagtcc
    13801 ggaacatatt tcattgcttt gcggataccc tccgaaccgt ctgctgcttc aataacagta
    13861 taatcggtat ggagtaatcc gcgtacatac gaacggatat ctgcattatc atcaattacc
    13921 aaaacagaag gtttggaaga atcatagcct ttttccagtt cctcttcttc gacagctaaa
    13981 gtttcattca ggttggaaga ggcaggagaa ccgggagaag caggatttaa aggaactgca
    14041 gagattgatg actttagaga atcttcggcc agaatagtct cacaagtctg taccggtaaa
    14101 tcaacggtaa agacagtgcc ctgcttttca tcactttcca cagaaattgt acctttatgc
    14161 aattcaacga aagctttaac cagtgcaagc ccgattcccg aaccggcgtg gtgcatgtct
    14221 attttataaa aacgatcgaa aatactccgg atatgttcgg cggaaatcat tgaaccggta
    14281 ttggcaacag taaaacgaat ccagcgagta tcctctttcg tcaaggaaga taaacgaacc
    14341 gttatctttc cattttccgg tgtgaacttg aacgcgttgg aaagaagatt aaaataaata
    14401 cgttccaact tttccatatc cgccaatgta tggtaatccg tatccggcat attatcaaaa
    14461 aagaaatgaa tgtgtttctt ccgggccgct gcaaggaatg attcgttcca gccctcaaaa
    14521 gaggaaagaa catctacctg aacaggtgta tattccatct taccgttctc gtatttacgg
    14581 aaatccagaa tctgattgac aagacgtaag aggatattca cgtttcgttg aatcagcatc
    14641 aacattcgat gctgatctcc acttagtgta tgatcggcca ataaatgttc taccggatcg
    14701 gcaaccaatg tcagcggagt acggaaatcg tgagatatat ttgtgaagaa caccagtttg
    14761 gcatgcgttg cctcttccag ttgatgagaa agctggataa gctgatcccg ctgttcttcc
    14821 agtttatccc gctgttcttc taattggtca cgttgttcct ctaacttgtc ccgttgttct
    14881 tccagctgtt tcttctgctc ggaaagttcc ttattcagac gatttttagc acgaagagat
    14941 ttatagacca ccaataataa acctgccacc aatagaagaa taaccaaacc accatacatc
    15001 accacctgct gtgtagcaac ccgagacaga tatccgccga tacgtccgtt caatgtttca
    15061 atcttctgat ccagttccga gatatgagtt gtctgaagtt gcatgacatg cgcatttgta
    15121 cggtcgacca ccgcagtgtt catgaccgtt tcccggggat aaggcttttt ctcaaggata
    15181 ttcattgcca gttgcatcac tttgtcgcca ttggtcggat aaataaaagt agcattcaac
    15241 acactgtcga gcaccatttc caatccgtta cctttgccgg ggagagcatc gataccgaca
    15301 aaaatcattt ccttctcccg tcccactttc tttgcagcct gataagctcc cggagcaata
    15361 cggtcattat gcgcatacac ggcgtctatc ttcggatgcc gacggagcat actatccatt
    15421 tccacttccg ccggttcacg ctcccacgca gcatccgctt tatcaatcag tttgatatcc
    15481 ggaaagttac tgatagcagc cataaatcct tgatggcgtt ccatggcagg agttgagccg
    15541 cccagtccgg taagttccac cacattccct tttcctttca ggcttgacgc aatataatta
    15601 cctaccgcac gtcctatttc ataattgtcg gcaccgatat aggcagtata tttatcagaa
    15661 agaatcttcc ggtctaccag gatgacaggt attccctttt gataggcttc ctctacaatc
    15721 ggagtcatgg gggccgcttc gttggcagag ataatcaata agtcaacccc ttcatctata
    15781 aaataatgaa cgtcttccgc ctgtttacga ttatcatccg cagccgaccg gatttcaacc
    15841 gatactccat cataaaacat tgcttcgcgg agaatttcat cattcatctt atgccgccag
    15901 gagtcatcgc tgcattgcgc caccccgata cggaaacgcg gtgcatcctg ccgacaagcc
    15961 gtcatgccaa gaagacagag caagactgct atccacttcg tatatcccat cattctaatc
    16021 attctcattt ttttcgtatt tctttctatg acccaaatgg acgattgaga acaaaaataa
    16081 gaaataaaac tgtgagtatg ctatctatca cccgattatt ctcatcatta ccctccaaag
    16141 aaatgcaaaa cagttcccaa tattcaaccg gaaactatta acaaaagtat aagacgtaat
    16201 acaaacactt aatcaatgtt ataaaacatc tctttttatt tggattattt gcaaatttag
    16261 cagaagtccg tatctttgca atgtgttttt catagtatta gatttaaggt taacaaagg
//
