LOCUS       c00033_gnlPro..        16287 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KDOFBDHO_33.
ACCESSION   c00033_gnlPro..
VERSION     c00033_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 17:00:29
            Original ID  :: gnl|Prokka|KDOFBDHO_33
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16287
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16287
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4326:7875](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4327..7875
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16287
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16287
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             184..1740
                     /locus_tag="ctg33_1"
                     /transl_table=11
                     /translation="MNDLLRKLPIGIQTFEKLRKGDYLYVDKTELVWKIAYTSTPYFLS
                     RPRRFGKSLLLSTFEAYFEGKKELFEGLAIEKLETKWEKHPVLHLDLNAEKYDSPERLY
                     DILSRQLTLWEIQYGKGIDENTLSGRFSGVIRRAYEQTGSSVVVLVDEYDKPLLQALGN
                     DVLLDEYRKTLKAFYGVLKSADRYLRFVFLTGVTKFSQVSVFSDLNQLQDITLWPDYGT
                     LCGITLQELLDTFQPEIKILAANNSISYDDAVQRMTRLYDGYHFCINSVGIFNPFSVLN
                     VLKSKVFDNYWFQTGTPTFLVEMLQETEYDLRTLLDGIEAPSSMFSEYRVDSNNPIPLI
                     YQSGYLTIKDFDREFGNYLLQFPNDEVRYGFINFLVPFYTGVRNSDQGFYIGKFVQELR
                     SGDYDAFLTRLQAFFADFTYELNEQTERHYQVVFYIVFKLMGQFTDAEVRSARGRADAV
                     VKTPKYIYVFEFKLHDTAEAALKQIDDKGYLIPYQADGREVIKIGVEFSAEKRNISRWL
                     V"
     CDS             complement(1751..2953)
                     /locus_tag="ctg33_2"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARRMASELALLPMWYA
                     EEGSAVLAPSAYNLGYVKKIQELLGLSVDLMTEPELAIEPNLDIRPWGWDVALRKRLSG
                     LGMDEALLPSMEQLDGLREYSHRSKAVSLLPELQLNEYFCGESYYLKTQEEWKTFVEER
                     ECCLLKAPLSGSGKGLNWCKGIFTPFISGWCTRVAASQGGIIAEPIYNKVEDFAMEFYS
                     DGTGEVTFMGYSLFYTGKSGMYEGNRLLSNEAIWKQLSQYVPSKVLTDLENCLKYRLSA
                     LVGTVYKGYLGVDMMICRFPENEKPVFRIHPCVEINLRMNMGVVARFLYDRYVRSGSTG
                     RFVIDYHPSEGEALQEHERMSATYPLEIREGRVYSGYLPLVPVHRRSCYRAWIWVTPDN
                     I"
     CDS             3116..4294
                     /locus_tag="ctg33_3"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             4327..7875
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg33_4"
                     /sec_met_domain="PFOR_II (E-value: 5.5e-19, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 6.4e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 5.7e-32, bitscore: 100.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-12, bitscore:
                     37.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.3e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.2e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.3e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.4e-25, bitscore: 78.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDYLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDNPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     EQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTAKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAQAENWTYCAENVKTKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIAADCTPAEVKELFAEWINNMLDADKTKE
                     LAAKIIPVVEANKDKCNHCKQIAELQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGAE"
     CDS             complement(8028..8894)
                     /locus_tag="ctg33_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAILLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRQLVDSW
                     IPKSENK"
     CDS             complement(8915..9739)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 90.2; E-value: 4.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg33_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 7.5e-29, bitscore:
                     90.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMVHFSTFFDAVNAGIGSFIIGFQHVLFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSPRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVSKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(9736..10962)
                     /locus_tag="ctg33_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGHEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTAGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSRQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETHEFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(11262..11600)
                     /locus_tag="ctg33_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMPQ
                     CSRMVGRALKQIPDDLSVPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVSE"
     CDS             11684..13072
                     /locus_tag="ctg33_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLFGV
                     FAFSSCEKNLYDESKQPEKEIQVKDLNIPAGFQWKLTQVAAGTVAATTPTMVSFFLDEA
                     CSKEEKIADIPVDTEISSLPLSIPTYVNTLYAQYKTSTNEIKKVAIPVNADRSFSLNIA
                     NDAKSKSNTTRSITRGHDIEDDIQLSKGVISHPKDGWGTIMFEDQFPSLGDYDFNDFVV
                     NYKVQFQGIKKVDKKYTAQYIQIGLRLKAIGGIFPYSPYLRLKEIDSDEVESIEVYETK
                     NVIPAIDGVDLVPNKHLIIDYSPLIKNLAKPAGSQYYNTEKNALVATSDLPEINILITL
                     KKRKEVKEILEGDEFDLYLKRNDSGTEIHMNGIEPITYQYPFNDKNLLPVYTNGDEEDD
                     NYYFSAGRLIWGLRVPGNAAHAIEKANFLEAFKGFAKWAQSSGKNEQNWYNQGNADKSL
                     LIHN"
     CDS             complement(13153..15990)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.6; E-value: 2.8e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg33_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 4.5e-20, bitscore:
                     61.6, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRMMGYTKWIAVLLCLLGMTACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDEGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNFPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKVGREKEMIFVGIDALPGKGNGLEMVLDSVLNATFIYPTNGDKVMQLAMN
                     ILEKKPYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRAKNRLNKELSEQKKQLEEQRDKLEEQRDQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADHTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVQVDVLSSFEDWNESFLAAARKKH
                     IHFSFDNMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKITVRLSSLTKEDTRWIR
                     FTVANTGSMISAEHIRSIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTISVESDEKQG
                     TVFTVDLPVQTCETILAEDTLMSSVSSVPLNPAFPGSPASSNLNETLAVEEEELEKGYD
                     SSKPSVLVIDDNADIRSYVRGLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGI
                     DGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRN
                     LIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGDSNLNVEDLGKDMGLS
                     RVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYR
                     EQFGESPTDLLKRKG"
ORIGIN
        1 cgtaagtcat aaaacaaatt cacctctgtg tcctccgtgt cctctgtggt gaaaaccgtg
       61 caagaatgag ctaaatgata attttccagt taaacaaaat tataacgccc gttctttgag
      121 atattgaaaa cgaaatatta cgaaaataat gattatcttt gaaccactaa aaggaaaata
      181 acaatgaatg acctgcttcg taaactccct atcgggatac agacctttga gaaacttcgt
      241 aagggcgatt atctatatgt agataaaaca gagcttgtat ggaaaatagc ttatacatct
      301 actccatact tcctgagtcg tccacgccgt tttggtaaaa gtcttcttct ctctaccttt
      361 gaagcctact ttgaaggaaa gaaagaactc ttcgaagggc ttgccattga aaaactggaa
      421 acgaaatggg aaaagcatcc tgtgctgcat ctggatttaa atgccgagaa gtacgattct
      481 ccggaaagac tttatgatat cctcagccgt caactcacct tatgggaaat ccaatatggc
      541 aaaggaatag acgagaacac tctttccggt cgtttctccg gtgtcatccg tcgtgcctac
      601 gaacaaaccg gtagcagcgt cgtagtcctg gtagacgaat acgacaaacc tctgttgcaa
      661 gctttaggta atgatgtctt actggatgaa taccgtaaaa ccctgaaagc cttttacgga
      721 gtattgaaaa gtgccgaccg ctacctgcgt ttcgtcttcc tcacaggagt gacgaaattc
      781 tcacaagtaa gtgtattcag tgacctcaac cagttgcagg acatcacttt atggcccgat
      841 tacggaaccc tttgcggcat cactcttcaa gaattattgg ataccttcca accggaaatc
      901 aagatacttg cagccaataa ttccatttct tatgatgacg cggtacaacg aatgacacgt
      961 ctctacgatg gctatcattt ttgcattaat tcagtaggta tcttcaaccc gttcagtgta
     1021 ctgaatgtcc tgaaatcaaa agtgttcgac aattactggt tccagaccgg cacaccgact
     1081 ttcctcgtcg agatgctgca agaaaccgaa tacgacctgc gtactttgct tgacgggatc
     1141 gaagcaccgt cttccatgtt ctccgaatat cgtgtagatt ccaataaccc gattccgttg
     1201 atttaccaaa gtggctatct gacgataaaa gatttcgata gggaatttgg taactatcta
     1261 ttgcaatttc ctaatgatga agtccgctac ggcttcatta atttcctggt tccattttac
     1321 accggagtga gaaacagtga ccaaggattt tacatcggca agtttgtaca agaacttcgt
     1381 tcgggagact acgatgcctt tcttacccgc ctgcaagcct tctttgccga tttcacctac
     1441 gaattgaacg agcagacaga gcgtcactac caagtagttt tctatattgt cttcaaactt
     1501 atgggacagt tcaccgatgc cgaagtacgc agcgcccgcg gtcgtgcaga tgccgtagtg
     1561 aaaacaccta aatatatcta tgtcttcgaa ttcaagctgc atgacacagc agaagcggca
     1621 ttgaagcaga tcgacgataa aggctatctg ataccgtatc aggcagacgg acgtgaagtg
     1681 ataaagatcg gggtggagtt cagtgcggaa aaacgcaata tcagtcgctg gctggtgtga
     1741 acagataaag ttaaatatta tcaggagtta cccatatcca tgcgcgatag caacttctcc
     1801 tatgaacagg aaccaaaggt aaataaccgg agtacactct accttccctg atttccaacg
     1861 gataagttgc ggacattcgt tcatgttcct gcaaggcttc accttccgaa ggatgataat
     1921 caatcacaaa acgccctgtt gaaccagaac gtacataacg gtcatataaa aaacgcgcaa
     1981 caactcccat attcatgcgc agattaattt ccacacaggg atgaatccga aaaaccggct
     2041 tttcattttc cggaaaccga caaatcatca tatcaacccc aagataacct ttataaacgg
     2101 ttcctaccaa cgcagaaagt ctatatttca aacagttctc caaatccgtc agaacctttg
     2161 aagggacata ttgcgaaagt tgtttccaga ttgcctcatt agaaagcaaa cgattccctt
     2221 catacattcc actctttccg gtatagaaga gggaatatcc cataaatgtc acttcacctg
     2281 taccatcgga ataaaactcc atggcaaagt cttctacctt attatatata ggttccgcaa
     2341 tgattccacc ctgcgaagca gccacacgcg tacaccaacc ggatataaaa ggagtaaata
     2401 tgcctttaca ccagttcaag cctttaccgc ttcccgaaag cggagctttc aacaggcagc
     2461 attcccgttc ttccacaaag gttttccatt cttcttgtgt cttcaaataa taagattctc
     2521 cgcagaaata ttcattcagt tgtaattccg gaagcaatga gacggcttta gaacgatggg
     2581 agtattcccg caaaccgtct aattgctcca tagaaggaag cagggcttca tccatgccca
     2641 gccctgaaag ccgtttccgc aaagctacat cccatcccca aggacgaata tccaaattcg
     2701 gttcaatagc aagttccggc tctgtcatca aatcaaccga aagtcctaat aattcctgta
     2761 tcttcttcac atagccgaga ttataagcgg aaggagctaa tacagcactc ccctcctctg
     2821 cataccacat cggaagcaaa gccaactcgg aagccatacg tctggcagaa gccggagcca
     2881 tataatttgt ttcaccgcta gccaacgcca agtcatgttc cggattgaat atataaagag
     2941 ccttttttgt catttcaaat gaattcaaaa ctttattctg caaatatata caggaaatag
     3001 tcaggaatga ctacaataaa cagaaagttg gaattaaaca cacaattttg ccatctctac
     3061 tttgcaaatc ctaaaaaaag cagtatattt gccacccgaa aaacaaagaa ctgaaatgga
     3121 atcattctac cgcacacacg cctacctcgt tgagcacacc aatgcccccg ttcgccgcga
     3181 tcttatggac gagatcgatt ggagcgaccg cctgattggt atcaaaggga cacgtggcgt
     3241 aggaaaaacc actttccttc tccaatacgc caaagagaaa ttcgggaacg accgttcctg
     3301 tctgttcatc aacatgaaca acttctattt ctcgggccac agcattgtag acttcgccaa
     3361 cgaatttcaa aaacgtggcg gaaaagtgtt gttgatcgac caggtgttca aacatccgga
     3421 atggagcaaa gagttacgca tgtgttacga ccgttttcct aacctgaaaa ttgtcttcac
     3481 cggctcgtcc gtgatgcgac tgaaagaaga aaatcttgaa ttacgtgata tcgccaagag
     3541 ctataacctg cgtggattct ctttccgtga attcctaaac ttgcaaacag gcatgaaatt
     3601 cagggcatat agcctcgaag aaattcttag cactcacgaa cagattgcca aaggagtact
     3661 ctccaaagtt cgtccgttgg attatttcca ggattacctg caccacggct tctatccgtt
     3721 cttcctcgaa aagcgtaact tttcggagaa tctgctgaaa acgatgaaca tgatggtgga
     3781 agtagatata cttctcatca aacaaattga actgaaatat ctttcaaaga taaaaaaatt
     3841 actatatttg ctcgctgtcg acgggccgaa ggctccaaat gtgagccaac tggcaagcga
     3901 catacagaca tctcgcgcca cggtgatgaa ctatatcaag tatctggcag atgcgcgact
     3961 cattaatctg gtttatccga aaggggaaga attccctaaa aaaccttcaa agataatgat
     4021 gcacaactcc aacctgatgt attccatcta tccggtgaaa gtggaagagc aggatgtgct
     4081 cgacacattc tttgcaaatt ctttatggaa agaccataag gtacataaag gagataaaaa
     4141 cgtctctttt atggtagacg aagtaatgcc gttcaaaatt tgccaggaag gcgcaaagat
     4201 caagaacaat ccgaatgtaa catacgcgtt gcataaggct gaaataggtc ggggcaacca
     4261 gatacctctc tggatgttcg gctttttata ttaaaagatt tatttactta aatatttaat
     4321 ttagttatga ctaaacagaa gaaattcatc acttgtgatg gtaaccaggc tgcagcgcat
     4381 atctcgtata tgttctctga agtagcagct atctacccca tcactccttc ttcgactatg
     4441 gctgagtacg tagacgaatg ggctgccgca ggacgtaaga acatcttcgg cgaaacagta
     4501 ttagtacagg aaatgcaatc tgaaggtggt gctgccggtg cagttcacgg ttctcttcag
     4561 gctggtgcgt tgactactac ttacactgct tcccagggtc ttctcctgat gatccctaac
     4621 atgtacaaaa ttgccggtga gttcttgcct tgcgtattcc atgtatctgc tcgtacattg
     4681 gcttctcacg cattgtgtat cttcggtgac caccaagacg taatgtcagc tcgtcagact
     4741 ggctttgcta tgttggctga aggctctgta caggaagtta tggatttggc tggtgttgct
     4801 cacttggcta ccatcaaatc tcgcgttccg ttcatgaact tcttcgatgg tttccgtaca
     4861 tctcacgaaa tccaaaagat tgaaatgttg gaaaatgatg atcttgctcc gctgatcgac
     4921 caggaagctt tggctgaatt ccgtgcccgc gcactgaacc cgatgaaacc ggtagctcgt
     4981 ggtatggctg aaaatcctga ccatttcttc caacatcgtg aatcatgcaa caactactat
     5041 gaagcagttc ctgctatcgt agaagaatac atgaatgaaa tttctaagat cacaggtcgt
     5101 aaatacggtt tgttcgatta ctatggtgca gaagatgcag aacgcgtaat tatcgctatg
     5161 ggttctgtaa cagaagctgc ccgcgaagct atcgactacc tggtagcaaa cggcgaaaaa
     5221 gtgggtatgg ttgccgtaca cctgtatcgt ccgttctctg ctaaacactt cttggctgct
     5281 gtacctaaga ctgctaagac tatcgcagtt cttgaccgta ctaaagaacc gggtgctaac
     5341 ggtgaacctc tttaccttga cgttaaagac tgcttctacg gtgcagaaaa tgctccggtt
     5401 atcgttggcg gtcgctacgg tttgggttca aaagatacta ctcctgctca aattctttca
     5461 gtattcgaaa acttggctat gccaatgccg aagaaccact tcactatcgg tatcgtagac
     5521 gacgttactt tcacttctct tcctcaaaaa gaagaaatcg ctttaggcgg cgaaggtatg
     5581 ttcgaagcta aattctacgg tttgggtgct gacggtacag taggtgctaa caagaactct
     5641 gtaaagatta tcggtgacaa cactgacaaa cactgccagg cttacttctc ttatgactct
     5701 aagaagtcgg gtggtttcac ttgttctcac ttgcgtttcg gtgataatcc gatccgttct
     5761 acttatttgg taaacactcc gaacttcgtt gcttgtcacg ttcaggctta cctgcacatg
     5821 tacgatgtaa ctcgtggttt gcgtaagaac ggttctttcc tgctgaacac aatctgggaa
     5881 ggtgaagaac tggctaagaa cctgcctaac aaggttaaga aatatttcgc acagaacaac
     5941 atttctgtat actatatcaa cgcaacacaa attgcactgg aaattggttt gggtaaccgt
     6001 accaacacaa tccttcaatc tgcattcttc cgtatcacag gcgttattcc tgtagaacaa
     6061 gctgttgagc agatgaagaa attcatcgtt aagtcttacg gcaagaaggg tgaagacgtt
     6121 gttaacaaga actatgctgc cgttgaccgt ggtggtgaat acaagacttt ggctgttgat
     6181 cctgcttggg ctaaccttcc ggatgacgca aaagctgaaa acaacgatcc tgcattcatc
     6241 aacgaagtag ttcgtccaat caatgcacaa gacggtgact tgttgccggt atctgcattc
     6301 aagggtatcg aagacggtac ttggtatcaa ggaactgcta aatacgaaaa acgtggtgta
     6361 gctgcattcg ttcctgaatg gaatgctgaa aactgtatcc agtgtaacaa gtgtgcatac
     6421 gtttgtcctc acgcttctat ccgtccgttc gtactcgacg ctgaagagca gaagggtgct
     6481 aagttcgaac aactgaaagc tgtaggtaaa gcattcgacg gtatgacatt ccgtatccag
     6541 gtggacgttc tcgactgtct gggttgcggt aactgtgccg acatctgtcc gggtaatccg
     6601 aagaagggtg gcaaagcatt gacaatgaaa cacctcgaaa gccaattggc tcaagctgaa
     6661 aactggactt actgtgctga aaacgtgaag actaaacaac atcttgttga tatcaaggct
     6721 aacgtgaaga actcacagtt cgctactccg ttgtttgagt tctccggcgc ttgctctggt
     6781 tgtggtgaaa ctccatacgt gaaattgatt tctcaattgt tcggtgaccg tgaaatggtt
     6841 gctaacgcta ccggatgttc ttctatctac tctggttctg ttccttctac tccgtatact
     6901 acaaacgaaa acggacacgg tcctgcttgg gctaactcac tgttcgaaga cttctgtgaa
     6961 ttcggtttgg gtatggaact ggctaacgaa aagatgcgtg ctcgtctcgt gaaagtgatg
     7021 aacgaggcta ttgctgctga ttgcactcct gctgaagtaa aagaactgtt cgctgaatgg
     7081 atcaacaata tgctggatgc ggacaagact aaggaattgg ctgctaagat cattccggtt
     7141 gttgaagcta acaaggataa atgtaaccac tgcaaacaaa tcgctgaact gcaacaatat
     7201 cttgtaaaac gcagccagtg gatcattggt ggtgacggtg cttcttacga tatcggttac
     7261 ggtggtcttg accatgtaat cgcttccggt aaggacgtta acatcctcgt tctggatact
     7321 gaagtttact ctaacacagg tggtcagtct tctaaagcta ctccggtagg tgctatcgct
     7381 aagttcgctg ctgctggtaa gcgcgtacgt aagaaagacc tcggtctgat ggctactact
     7441 tacggttatg tatatgttgc acagatcgct atgggtgctg accaagctca aactctgaaa
     7501 gctatccgtg aagctgaagc atatccggga ccatctttga ttatcgctta tgctccatgt
     7561 atcaaccacg gtctgaaagc aggtatgggt aagagccaag aagaagaaga aaaagctgtt
     7621 aagtgcggtt actggcactt gtggcgttac aacccggctt tggaagaaga aggcaagaac
     7681 ccattccaat tggatagcaa agaaccgaac tgggaagatt tccaaggttt cttgaagggt
     7741 gaagttcgtt acgcttctgt aatgaaacaa tatcctgctg aagctgaaga actgttcaaa
     7801 gctgctgaag aaaacgctaa atggcgttac aacagctaca aacgtttggc tagagaaaac
     7861 tggggtgctg aataatagta ataccctata aatataaaac ggtaatcttg tagaagatta
     7921 ccgttttttt attgtatgaa ctctgtctaa cataaacaat actccctttt tcccactaga
     7981 gttcatgtct attttatatt taaaattaaa aataacaatg ctccaatcta tttattctct
     8041 gacttcggaa tccaactatc caccaactgc cgatgttcat ccctccattt acgggctatt
     8101 tcttcttcat ccatccgggc atccttcata gctgtcataa aagagctaag ttcttctgtc
     8161 gttagtttga tgttgccaaa gaattcggca gcaaacggat ctttctcact gaatcctttc
     8221 catgcaatag catgtatttc ttccaagtct ccatatactt tcttcggatc atccaagaat
     8281 ttcaagtcaa actggtcgaa catccaatgc ggtgtccacc ccgtgatgac aatccattct
     8341 cctttgtcca tcgctttttt caaagaagcc agcatggtgg aactacttga agtcatgagg
     8401 gtatacccat caagtccgta agcagcaatg gccttatcgg tcgtcttcat aattcctgct
     8461 ccggcatcaa ttcccactat ttcagaagag aaacggtctt tattagcttc cagctcacta
     8521 atagactgga tcgtaacata ttgaggaaca accagtccta cacgggcttc tccatatacc
     8581 tcacccaaaa attcgatgct gtctccatac tgatccatat aatctttcat cgttattggt
     8641 aaccaggcat ccagaaagac atcagatttc tttcctgaca tagatacaaa gatgggggca
     8701 aggtcagcat tttgcagttc aacctcatat ccatgttctt ccaataccac cttagccaaa
     8761 tgactcatgg caataccttc cagccaattg gcataggcta tctttacttt ctttttctct
     8821 aaatctgaat tagtacagga agccagcaaa agtatagctg acaatactat tcctactatt
     8881 ttatatattc tcatacgtat tttatccttt ccgtttagtt cttatttttt cgtcctgcca
     8941 ttccttgtgt gatacggtct aagatgatag ctaaaataac aactgcgata ccaccttcaa
     9001 acccaagtcc gattttcatt tgggtaatac ctttcaatac aatttctccc agaccaccgg
     9061 cagcaatcat ggcagcaatg acaaccatag aaagcgacat cattattgtc tgattgacac
     9121 ctgtcaggat ggttggcaac gccaaaggaa gctgcacttt atacaataac tgccaacggg
     9181 tagccccgaa cgaacgggaa gcttccacta catttttaga aacttgccga attcccaatc
     9241 cagtaaggcg gaccacagga ggcatagcaa agataatggt ggcaaacact cccggcactg
     9301 ctcccaatcc gaaaaacaaa acggcaggaa tcagataaac aaaagcaggc atcgtctgca
     9361 tcaagtcgag aacaggacga agtattttct ctgcacgcgg actgtttgcc gtccacactc
     9421 ctaaaggtac accaacaatc agagccagac aggtagatga aaaaacgaga gccagggttt
     9481 gcatagtagc ctcccaaaat cccattccat aaatcagtaa taatcctaat gcggtgaaaa
     9541 ttgccgtacc acgtcctgcc ttcatccatg cgagtgcagc aagcactaga atggttatat
     9601 aaaaaggtat tccaaaaagt acgtgttgga atcctataat aaaactaccg atgcctgcat
     9661 tcacggcatc aaagaaagtg gaaaaatgta ccatcatcca attgatggcc atctctatat
     9721 attgtcctat atttatcata aatctattgc gttttgaatt atttcgttta tttcttcttt
     9781 atctttcccc gtcacttcga tgattaagga ggaaagcggg attgttccta aaaactcatg
     9841 cgtctcatca atcacccata ccggcgaatt gctctttgtc attaaaggaa gtatatcctc
     9901 caacactgta tcctccaata cagaatgtac ttctgtacgc acaatcgttt caatggattt
     9961 ttcctgtctg ctacgtaact taagcaggtc gttcagacgt acttctccga ccagtttatc
    10021 atcggcgtct atgacaggta atacggtgat attcttcgca cgcatcttac gaatcaatac
    10081 ttcaggtccc tctttcttca gacgggccac cagtggtttg tcaatcatta aagaagaagc
    10141 ggtgataatt ttactcctgt ccacgttttc aacaaaacgg gctacataat cgttagccgg
    10201 ttcggtcagt atttcttctg aagtacctac ctgcaccacc tctccgtctt tcataatggc
    10261 aatacggtcg cccagtttaa tcgcttcact caagtcatgg gtaataaaga caattgtttt
    10321 tttcatcttc gactgcaaag ccagcagttc atcctgcatt tgcacacgaa tcagaggatc
    10381 gagcgcagag aaagcctcat ccattaaaag cacttcggga ttattagcca gagcacgggc
    10441 cagtccgaca cgctgttgca ttccaccgga aagctcgccc accatctgat tttcatatcc
    10501 tttcaatccg acaagcttca tactttccat cgctttcttc tcacgttcct ctttcttcac
    10561 tccctgaagt tcgagaccga acgcgatatt gctcaatacg gaacggtgag gtaacagacc
    10621 gaaattctgg aaaaccatcg ccaactcttt ccggcgaact tgcaataact ctttttcgga
    10681 tattttagat atatctactc cgtttacaag cacttgtccg gcagtaggac gtatcagacg
    10741 attgatacaa cgcagtaatg tcgattttcc acttcccgag agtcccatta tcacaaaaaa
    10801 ctctccttca ttaattgaaa gattggcatc tttcactcct accgtacaac cggtatcttt
    10861 cagaatttcc tctttactct tatctttttt caacatcttg agtgctttct gcttctcgtg
    10921 accaaagata aggtacaaat cctttatttc tattttactc atataatata ttggtttaga
    10981 ttataatagt tgttttgttt tcaactgccg cgttcctcat tctcacttac gataaacaag
    11041 ttgaatgttc gcatggttca atcatgtcac atgacaacat gacgatccga cgttttttaa
    11101 aatggtttaa aaagacagac tgagtagttt aaaaggaata gaatttgata agattatcct
    11161 ctcaatgaac agtagaaaac agtattttca taaataaata acagtctgtt cttgcatatt
    11221 gttggcacaa agataaggaa aatagattaa atatgcaaat ttcattcaga tacggagtaa
    11281 ttccaaagat gctttttcaa gtctacgcat ccattttgct tgaaagagat cccttcttcc
    11341 aacaagagtt gtttctgctc tgtccaaccc ggaacaaggc gtcccgatgc attgacaacc
    11401 cggtgacaag gcacagataa atcatccgga atctgtttca aagcacgccc caccatacgg
    11461 gaacattgag gcattcccaa taatgcggca attcccccat aggtagaaac tttacctacc
    11521 ggaatttccc gaacaacctg atacacctct tgacaaaagg atgcggagag actcgctttg
    11581 tctactttat aatctttcat cactcaaaca ttactttatt tcagttccaa aactagataa
    11641 aaaggaaaga atttgcaaat aataaaagta tttcaaataa aatatgcaac tttatttgct
    11701 ttatttacaa ataatcccga cctttgtacc cattaaaagc aaccctatta ttaacaaaac
    11761 aagcactgct gttatgaaaa agaagacaat tctattcgct tcttgtttat ttggagtatt
    11821 cgctttcagc tcctgtgaga agaaccttta tgatgaaagt aaacaacccg aaaaagaaat
    11881 tcaagtaaaa gacctgaata tacccgcagg ctttcaatgg aaattaactc aagtagccgc
    11941 aggaacagta gctgctacta cccccactat ggtttccttc tttttggatg aagcatgtag
    12001 taaagaagag aaaatagccg acattcctgt agatacagaa atttcaagtc tccctttgag
    12061 catcccaacc tacgtaaata cattgtatgc ccagtacaaa accagcacca atgaaatcaa
    12121 aaaagtagcc atacctgtaa atgcagatag aagtttctca ctgaacattg ctaatgatgc
    12181 caaatccaaa tctaacacca cccggtcaat cactcgtggg catgatatag aagatgacat
    12241 ccaattgtca aaaggagtca tttctcatcc caaagatggt tggggaacaa tcatgtttga
    12301 agaccaattc ccatcattag gagattatga ctttaatgat tttgtagtca attataaggt
    12361 gcagttccaa ggtattaaaa aggttgacaa aaaatacact gcgcagtata tacaaatagg
    12421 attacgtcta aaagctatcg gaggaatatt cccttattct ccttatttaa gactgaaaga
    12481 aatagattct gacgaagtgg aaagtataga agtttatgaa actaaaaacg tgattcctgc
    12541 gatcgacgga gtagatcttg tccccaataa acatcttatc attgattaca gccctttaat
    12601 taagaatctg gctaaacctg caggcagcca atattataat acagaaaaga atgctttggt
    12661 agcaacaagt gatttaccgg agatcaatat tctgatcacc ctaaagaaga gaaaagaagt
    12721 aaaggaaata ttagaaggcg atgaattcga cttgtattta aaacgtaatg atagcggaac
    12781 agaaatccat atgaatggta ttgaaccgat cacttaccaa tatccattca atgataaaaa
    12841 tctgctaccg gtatatacaa acggggacga agaagatgat aattattatt ttagtgcagg
    12901 acgcctgatt tggggattaa gagtaccagg caacgcagcg catgctattg aaaaagctaa
    12961 tttcttggaa gcctttaaag gatttgcaaa atgggcgcaa agtagtggca aaaacgaaca
    13021 aaactggtat aatcaaggaa acgcagataa aagtttattg attcataact aacacatatc
    13081 aataaatccc ggtaaacatt gaaaattcaa gttaccggga tttattgtat tctgacgtga
    13141 atagttttga ttctatcctt tccttttcag caaatctgtc ggactttcgc caaactgctc
    13201 tctataacat ttggtaaaat aagaaggaga actaaaacca acttcataac caatctctgc
    13261 cactgtcata tccgacgaag caagcaagga agcagctttc tttaaacgag cgatacgaag
    13321 caattcattc ggagaataat tagtcaggga ttttattttg cgatagagct gcacacgact
    13381 taatcccata tccttaccca aatcttctac attcaaattt gagtctccca tctttgcttc
    13441 aatcaaagcc ttgaattttt ccacaaagtc tttatccata tcacagacat cctctttcgc
    13501 caacgtttgt ccgtcaccaa agaactgttt caggcggcga tgtgaatcta tcagattacg
    13561 aacgcgtgcc aacagcaatt gcgaactgaa gggcttggag atataagaat ctgcacctcc
    13621 gtcatacccc tgaatccgtt gttcatccaa agaacaggct gtcaataaga tgacagggat
    13681 atgacaggtt tgcagttcgc ttttcagccg acggcaacac tctattccat caataccagg
    13741 catcatcaca tcagagatta tcaagtccgg gacatatttc attgctttgc ggatgccctc
    13801 cgaaccgtct gctgcttcaa ttacagtata atcggtatgg agtaatccgc gtacatacga
    13861 acggatatct gcattatcat caattaccaa aacggaaggc ttggaagaat catagccttt
    13921 ttccagttcc tcttcttcga cagctaaagt ttcattcagg ttggaagagg cgggagatcc
    13981 gggaaaagca ggatttaaag gaactgaaga gactgatgac attagagtat cttcggccag
    14041 aatagtttca caagtctgta ccggtaaatc aacggtaaag acagtgccct gcttttcatc
    14101 actttccaca gaaattgtac ctttatgcaa ttcaacgaaa gctttgacca atgcaagtcc
    14161 gattcccgaa ccggcatggt gcatgtctat tttataaaaa cgatcgaaaa tgctccgaat
    14221 atgttcggcg gaaatcattg aaccggtatt ggcaacagta aaacgaatcc agcgagtatc
    14281 ctctttcgtt aaggaagata aacgaaccgt tatctttcca ttttccggtg tgaacttgaa
    14341 cgcgttggaa agaagattaa aataaatacg ttccaacttt tccatatccg ccaatgtatg
    14401 gtaatccgta tccggcatat tatcaaaaga gaaatgaatg tgtttcttcc gggccgctgc
    14461 aaggaatgat tcgttccagt cctcaaaaga ggaaagaaca tctacctgaa caggtgtata
    14521 ttccatctta ccgttctcgt atttacggaa atccagaatc tgattgacaa gacgtaaaag
    14581 gatattcacg tttcgttgaa tcagcatcaa cattcgatgc tgatctccac ttagtgtatg
    14641 atcggccaat aaatgttcta ccggatcggc aaccaatgta agcggagtac ggaaatcgtg
    14701 agatatattt gtgaagaaaa ccagtttggc atgcgttgcc tcttccagtt gatgagaaag
    14761 ctggatgagc tgatcccgtt gctcttccag tttgtcccgc tgttcttcta attggtcacg
    14821 ttgttcctct aacttgtccc gttgttcttc cagctgtttc ttctgctcgg aaagttcctt
    14881 attcagacga tttttagcac gaagagattt atagactacc aataataaac ctgccaccaa
    14941 tagaagaatg accaaaccac catacatcac cacctgctgt gtagcaaccc gagacagata
    15001 tccgccgata cgtccgttca atgtttcaat cttctgatcc agttccgaga tatgagttgt
    15061 ctgaagttgc atgacatgcg catttgtacg gtcgaccacc gcagtgttca tgaccgtttc
    15121 ccggggataa ggctttttct caaggatatt cattgccagt tgcatcactt tgtcgccatt
    15181 ggtcggataa ataaaagtag cattcaacac actgtcgagc accatttcca atccgttacc
    15241 tttgccgggg agagcatcga taccgacaaa aatcatttcc ttctcccgtc ccactttctt
    15301 tgcagcctga taagctcccg gagcaatacg gtcattatgc gcatacacgg cgtctatctt
    15361 cggatgccga cggagcatac tatccatttc cacttccgcc ggttcacgct cccacgcagc
    15421 atccgcttta tcaatcagtt tgatatccgg aaagttactg atagcagcca taaatccttg
    15481 atggcgttcc atggcaggag ttgagccacc cagtccggta agttccacca cattcccttt
    15541 tcctttcaag cttgacgcaa tataattgcc taccgcacgt cctatttcat aattgtcggc
    15601 accgatatag gcagtatatt tatcagaaag aatcttccgg tctaccagga tgacaggtat
    15661 tcccttttga taggcttcct ctacaatcgg agtcatgggg gccgcttcgt tggcagagat
    15721 aatcaataag tcaacccctt catctataaa ataatgaacg tcttccgcct gtttacgatt
    15781 atcatccgca gccgaccgga tttcaaccga tactccatca taaaacattg cttcgcggag
    15841 aatttcatca ttcatcttat gccgccagga gtcatcgctg cattgcgcca ccccgatacg
    15901 gaaacgcggt gcatcctgcc gacaagccgt catgccaaga agacagagca agactgctat
    15961 ccacttcgta tatcccatca ttctaatcat tctcattttt ttcgtatttc tttctatgac
    16021 ctaaatagac gattgagaac aaaaataaga aataaaactg tgagtatgct atctatcacc
    16081 caattattct catcattacc ctccaaagaa atgcaaaaca gttcccaata ttcaatcgga
    16141 aattattaac aaaagtataa agcgtaagac aaacactcaa taaatgttat aaaacatctc
    16201 tttttatttg gattatttgc agatttagca gaagtccgta tctttgcaat gtgtttttca
    16261 tagtattaga tttaaggtta acaaagg
//
