LOCUS       gnlProkkaHHHGOLHG_38   13620 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HHHGOLHG_38.
ACCESSION   gnlProkkaHHHGOLHG_38
VERSION     gnlProkkaHHHGOLHG_38
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 09:06:05
            Original ID  :: gnl|Prokka|HHHGOLHG_38
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 9617
            Orig. end    :: 23237
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13620
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10375]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10375
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13620
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13620
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2585..3160
                     /locus_tag="ctg38_11"
                     /transl_table=11
                     /translation="MGMGEPLDNLDEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQ
                     RFIEENDCHLAISLHSPLTVQRAELMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVF
                     KGLNDSQVYAKELLKLLRGLDCRVNLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFT
                     TIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3866..4219
                     /locus_tag="ctg38_12"
                     /transl_table=11
                     /translation="MKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGD
                     FMGGPYVSHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIP
                     LGEASKEAEQTNK"
     CDS             4224..5318
                     /locus_tag="ctg38_13"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPIVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5328..6569
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg38_14"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(6589..7053)
                     /locus_tag="ctg38_15"
                     /transl_table=11
                     /translation="MVGDLFRHFSNQSVLYGSQQLARVVGTERRKLLFKVFGMIGVVDK
                     TYIDGNSQLRLRRITVGRYCLVVLIVTCDFSVNLQVGILIRLEQLQTGLPDEDIFQVLI
                     EFGCQRSIYILRLDREVGYRNGLYLIIIDRRSVKLIGNSARNDYQRQAEQ"
     CDS             7089..7862
                     /locus_tag="ctg38_16"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDEPTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             8049..8264
                     /locus_tag="ctg38_17"
                     /transl_table=11
                     /translation="MVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAPQ
                     TEAPATNAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg38_18"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10375
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_19"
                     /sec_met_domain="PqqD_RRE (E-value: 2e-11, bitscore: 34.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 7.3e-18, bitscore: 55.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVVYRNLLLFI"
     CDS             complement(10368..10652)
                     /locus_tag="ctg38_20"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10689..11756)
                     /locus_tag="ctg38_21"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSAGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11829..13340)
                     /locus_tag="ctg38_22"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 gctcatttcc agttgaatgg cttttcgcag gcggatgcca agtcgttctc aaagcaatat
       61 ttgtctactt actccaaggc tttgtccaca caacaggaag atattcttgc ttcgtgggtg
      121 ctggttaaac aaccgcgctg tttaagtgta ttgctcaacg agctggtttc gttcggtcag
      181 tacgatgctc tcaatgaata tatgagtgga tattgccggc tcaatgaggt tgggcaattc
      241 tatgacagtg tgttacggcg tttgtcggct gattatggtt tcgaagagat tggaagaacg
      301 cttctgatgc tttcacttac tttagaagga tttaccgaag atgaagtgaa gagtatggca
      361 gacattaatc agatactttg gtcgcagttg agagtggaaa tgagcagctg gctcaccaac
      421 aaaggagggc gatattgcat tggtgacaca caaatggtag aggcgatcga acgctatttc
      481 gctcaagatg acgaatgtat agatgatagt cgccatgaaa ttatttccgc tttgctggat
      541 gaggaagaga tcctttctca tccgttgact tttgccgatt ataactatcg catgaaacag
      601 ttctgctacc atgattcgta tcgctataaa gtggagatta cctatcaatg ctataagatg
      661 caagaatggg atatattgaa ggattggatt tgtgatgtgg agattttcga gattctgtat
      721 cgcacgaatc gttctctgtt ggaagatagc tggaaggcga tcatgaacga caatcctgaa
      781 gttacgcctg aagtctatgc cgaattggac tttgatgaga tcgattcttt tttaattcct
      841 gtcattgcta atgatatggc tactttcttg agcagttctt tccatctgac gaaggcggca
      901 gctgctgtga gtgagaagag tatggaaggt gctgccatgc cactcattgc caagtcggta
      961 ttgaagatga atgagggatg ccgctatgcc cgtaatgaag agtacgaaac ggcatgcgac
     1021 tgtttcttga aagcattggt gatgcaggaa aacattgtac cgactccgga actggagatt
     1081 gccaacacct gccgaaatct agctctggca tattactaca atgagcaata caatgaagca
     1141 gtgacctatt tgaatagggc gcttgattat catgcggctt ctgctgacga gaagagtcag
     1201 gcagaagtca ttgaactttc cgaatatctg gcttattgtg attactataa ggatgaggaa
     1261 gagagtgctg ccgagaaatt ccggaaagta gctgaaatgc acgagtcatt gaatggcaga
     1321 ctgtccggtg gagtggctaa atgtttgcgt atgcagggta aatgtcttta ttatatcaaa
     1381 cgatacgatg aagcatggat gctgatgaat caggcgttgg acattgctat acagatagac
     1441 agcaaaaaac agatcgtcgc ttgtcataaa cagttgtatt atctatgcag ggaattcaaa
     1501 cggatgatga atgaacgtgg cgatgagcag gcgtctactt tatttttccg tgagtctctt
     1561 ctgcatgaaa tgtatttcag cgaaaaaccg cgtctggcgg aactgactgt ccgctacgag
     1621 gcattgagat gtgatattat gcagcagtat tacatgaata aaaactatga taacgtgatt
     1681 cgtattgcga cgtctttgga tattcacgat gatgctgacc ctaatgcttc ctgtctggta
     1741 tattattaca aagcacaggc ttatgtgaag ttggagaatt atccaatggc gaaagaggct
     1801 ttcttcagag aacttgaatt gcgaaagaag tatttgggat gggaggaaga agatacgatt
     1861 ctggcttgtc agaacttagg ggttttgcac agcttttgta atgaacggga agaggcgttg
     1921 gcttgtttcc gtgaggcgta cggtcatgaa gtgaaaaaga atggcgagga ttctgaaatg
     1981 gcgcaaaagc tacttcaata tatcagcgtg gttgaatcat aacggaggca tacttccctt
     2041 ttttgttaac ttttacattc ctgctatacg gaaatcgact ttatttcctt acatttgcag
     2101 atataaacta tcaacagaaa gaagaatgtc taaatatccc cttttaggaa tgactcttgt
     2161 agagcttcaa tcattgacaa aaagactggg tatgcccggc tttgctgcca agcagattgc
     2221 atcctggctt tacgaaaaga aggtagcctc gattgatgat atgactaatt tgtcattgaa
     2281 acaccgggag ttgctcaagc agaactatga ggtgggagcg gaagctccgg tagatgaaat
     2341 gcgctctgta gatggtacgg tgaagtatct ttataaagtg ggtgagaacc attttgtaga
     2401 gtcggtttat ataccggatg atgaccgggc aacgttgtgc gtgtcgtcac aagtaggttg
     2461 caagatgaac tgtaagttct gtatgaccgg caaacagggg tatacggcta acctgaccgc
     2521 cagccagatc atgaaccaga ttcattcgct gccggaacgg gacaaactga ctaatgtcgt
     2581 aatgatggga atgggcgagc cgctcgataa cctggatgag gtattgaaag cattggaact
     2641 actgaccgct acctacggtt acgcatggag tccgaagcgt atcacgcttt ctactgtcgg
     2701 gctacggaaa ggattgcagc gttttatcga agaaaatgac tgccaccttg ccatcagcct
     2761 tcactctccg ctgaccgttc agcgtgctga attaatgccg gcggaaaagg cgttttcaat
     2821 caccgaaatg gtggaactgt taaaaaacta tgattttagt aaacaacgtc gactttcgtt
     2881 tgaatatatt gtttttaaag ggctcaatga ttcgcaggtc tatgccaaag agttgctgaa
     2941 acttcttcgc gggctggatt gcagggtgaa tctgattcgt tttcatgcca taccgggggt
     3001 agacctcgag ggggcggata tggatacgat gacccgtttt cgtgattatc tgacgtcaca
     3061 cggacttttc accactatcc gttcatccag gggcgaagat atttttgctg cttgcggtat
     3121 gctgtcgaca gcgaaacagg agaaaaataa tgaaagttaa tatataaaac cgaacatcat
     3181 gaaaaagtac tcttttattt tatgcatcgc tttggtagcc tttgtcgttg catcttgtgg
     3241 tctgaaagga aatcacacct ctagtggtcg tgcttacgag cttttggttg tagtagatca
     3301 cggtgtttgg gatcgtgctg ccggaagggc tttacatgat gcgctcgatg ctgatatgcc
     3361 cggtttgccg cagtcggaac cttctttccg gattatgtat acttcgccga aagattatga
     3421 ttctacgctg aagttgatac gtaacattat tattgtagat atacaggata tatatacgaa
     3481 agcctcgttc aaatatgcga aggacgtgta tgccaatccg cagatgatat tgactatcca
     3541 ggctccgaac gaagaagagt ttgagaagtt tgtggaagag aacaaaaaga cgattgtcga
     3601 cttctttacc cgtgcggaaa tgaatcgtca gattacgttc ctggaaggga aacacagtaa
     3661 tttcatttcg cagaaagtgg acagtttgtt cggatgcgac atctgggtgg atgccgaact
     3721 ggctaattca aagaccgggg atgatttctt ctgggcttct accaacacag gtagtgccga
     3781 ccgtaacttt gtgatgtact cttatccgta cactgacaag gatacgttta ccaaagaata
     3841 ttttgtgcac aaacgtgact ccgtgatgaa agccaatatc cccggattca aggaaggcgt
     3901 ttatatgtcg accgatagtt tgctgaccga tgtccgtccg atcaatgtgc agaacagcta
     3961 cacaatggaa gcacgtggtc tgtggcgtat gaagggcgac tttatgggtg gtccgtatgt
     4021 atctcatact cgtctggacg agaagaacca acgaattatt actgcagaaa tatttgttta
     4081 ttcacctgat aaaatgaaac gcaacctggt acgccagatg gaagcatctc tgtatacact
     4141 gaaacttccg aatgaagttc agcagaagca gattccattg ggagaagcat ctaaggaagc
     4201 ggaacaaact aataaataaa aacatggaag ataacaagat aaggataggt atcacccaag
     4261 gagatattaa cggggtgggc tatgaggtga ttcttaagac attttccgac cctacgatgt
     4321 tggaactatg tactccgatc atttatggct caccgaaagt agcggcttat catcgcaaag
     4381 cgctggatat acaggccaat ttcagcattg tcaactctgc taccgaagcg gggtacaacc
     4441 gtttgagcgt ggtgaactgt acggatgatg aggtgaaagt ggaattttcc aaacccgacc
     4501 ccgaagccgg taaagctgcg ctgggggctt tggaacgtgc catcgaagaa tatcgcgaag
     4561 ggttgataga cgttatcgta acagctccga tcaacaaaca tacgattcag tcggaagagt
     4621 tctccttccc cggacatacg gaatatatcg aagaacgtct gggcaatggt gataagtcat
     4681 tgatgatttt gatgaagaat gacttccggg tggctttggt gactacacat atccctgtca
     4741 gggagatcgc gactacgatt accaaagaac tgattcaaga gaaactgatg atattccatc
     4801 gttgtctgaa acaggatttc ggtatcggcg ctccgcgtat tgcggtgctc tctctcaatc
     4861 ctcatgccgg agacggtggt ttgttgggaa tggaagagca ggaagtgatt atccctgcca
     4921 tgaaagaaat ggaagagaaa ggaatccttt gctacggtcc ttatgcggcc gacggcttta
     4981 tgggttcggg caattatact cattttgacg gtatcctggc gatgtatcac gatcagggac
     5041 tggctccgtt caaggccttg gctatggaag acggggtgaa ctatacggca ggcctgccga
     5101 tagtacgtac ttctccggct catggaacgg catacgatat tgcaggcaag ggagtggctt
     5161 gtgaagattc tttccgtcag gcaatctatg ttgccatcga cgtgttccgt aatcgtcagc
     5221 gggaaaaagt ggctcgtgcc aatccgttgc gtaaacagta ttacgagaaa cgtgacgata
     5281 gtgataaact gaagctggat acagtagacg aagattaaaa acgagtgatg acgaaagcag
     5341 agatacaaca agtgaaacag cgtttcggta ttattggaaa tactgaagca ttgtcgcgcg
     5401 ccatagatgt tgccattcag gtagctccta ccgatttgtc tgtgctgatt accggagaaa
     5461 gtggagtcgg aaaagaaagt tttccgcaga ttattcatca atatagccgg aggaagcacg
     5521 gacagtatat tgctgtcaac tgtggcgcta ttccggaagg tacgattgat tccgaactgt
     5581 tcggacatga gaaaggtgcg tttaccggtg cgattggcga acggaaaggg tactttggcg
     5641 aagctgacgg cggtactatt tttcttgatg aagtagggga gttgccgatg tctacccagg
     5701 cacgtttgct ccgtgtactg gagagtggcg agtttatgaa agtaggttcg tccaaagtac
     5761 aaaaaacgga tgtgcgtgtg gtggcggcta ccaacgtcaa tcttacacaa gcgattgcag
     5821 aaggacgttt ccgtgaagat ttatattacc ggttgaatac ggtgcctatc cagataccgc
     5881 ctttgcgtga acgtggtgac gatgtacttt tgttgttccg taagttttcc gcagactttg
     5941 cagagaaata ccggatgcct gctattcagt tgacggagga tgcgaagaaa gagttgttgg
     6001 cttacccgtg gcccggaaac gtgcgtcagt tgaagaacat caccgagcaa atatctatca
     6061 ttgaaaccaa tagggagatc tctgctgcta tcttgcagaa ttatcttccc gcacaaaata
     6121 cgcaacgtct tcccgcgttg atgggaacgc gtgagagtaa aggctttgag agcgaacggg
     6181 agattcttta ttctgttctg ttcgatatgc gccaggaagt ggcggagctg aagaagatgg
     6241 tgcacaacct gatggcggaa cgtgccggac aggtggggca ggtaggacaa atgggaacgg
     6301 tggttactac tccggtagtg acggcgcatc aaccttcggt acctgctatc attcacacca
     6361 tgcagcctac ggtttgcaag gatgatgatg acatacaaga cacggaagaa tatgtagaag
     6421 aatccccttt gtcactggac gaagtggaga aagaaatgat acgcaaggca cttgagaggc
     6481 atcatggaaa gcggaagagt gcggccaagg acttgaatat ttccgagcgt acactttata
     6541 gaaaaataaa agaatatgaa ttggattaag aaaataatac gccctttgtt actgttcggc
     6601 ttgccgttgg tagtcattgc gtgcactgtt tcctataagt ttaacggatc gtctatcaat
     6661 tatgataagg taaagaccat ttcgatagcc gacttcccga tcaagtcgga gtatgtatat
     6721 gctccgttgg caaccaaatt caatgaggac ctgaaagata tcttcatccg gcagacccgt
     6781 ctgcaactgc tcaagccgaa tcagaatgcc gacttgcaga ttgacggaga aatcacaggt
     6841 tacaatcagt acaaccaggc agtatctgcc gacggttatt cttcggagac gaagttgact
     6901 attaccgtca atgtacgttt tgtcaacaac accaatcatg ccgaagactt tgaacaacag
     6961 ttttctgcgt tccgtaccta cgactctagc cagttgctga ctgccgtaca ggacggattg
     7021 attgctgaaa tgtctaaaga gatcaccgac caaattttta atgcaactgt agcaaactgg
     7081 taatataaat gacttctgtt aactttcaac aatggattca gcatcccgag acgctgaata
     7141 gggatacttt gtacgaactg cgcaatcttc ttgcgaggta tccgtatttt cagtcacttc
     7201 gtctgctgta tctgaagaat ctgtatattc tccatgatat tagtttcggt ggagaactgc
     7261 ggaaagcagt tctttacatt gcagacagac ggcagttgtt ccggttgatt gaaggtgacc
     7321 gctatgatgt gcaggcacgg aaaaagggag tacctctcac ggaggtactg aaagacgaac
     7381 cgtccgtaga ccgcacatta gcattgatcg acgctttctt gtccacagta cccgaagagg
     7441 tgactgcccg gaccagcttc gactattcga tggattacac ctcttatctt ttggaggaga
     7501 ctccggccac ggaacagtcg gccgaagaaa cgcccaaact caaaggctac gaactgattg
     7561 acgactttat agaaaagagc gagagcgact ctcccctctg catgaaacct ttaagagaag
     7621 aaatgccatc ttcgccaacc tcttcggacg aacctaccga agaagaaacg atgaaggaag
     7681 aagaggaaga tgacagctgt tttacggaaa ctttggcaaa aatctatgtt aaacagcaac
     7741 gatattcaaa agctcttgaa ataattaaaa aattaagctt gaaatatcca aaaaaaaatg
     7801 cttactttgc agaccaaatc agatttttgg agaaattgat tattaacgct aattcaaaat
     7861 aactaaaaat gtacttatta ttcgttatct taatggttat tgcagccttg ttgatgtgtt
     7921 tcatcgtgct gattcagaac tcaaaaggag gcggacttgc ttctggtttc tcttcatcta
     7981 acgccatcat gggcgtgcgc aagactacag attttctgga aaaagcaaca tggggcttag
     8041 ctatcttcat ggtggtaatg agcattgcta ctgcttatgt agttcctcgc tctgctgttg
     8101 ctaaagacgc agtgttggaa caggcacaga aagaacaaca gactaacccg tataacttac
     8161 ccgcaggtac ggctgcgccg caaactgaag ctcctgctac caatgcacct gctacagaaa
     8221 ctccggcacc ggctactgaa actcctgctc ctgcagcaga gtaattcact ccgtcgtcag
     8281 gtaagacttt gggggtaaaa ccattaatgg gaaggtgcag acggatgctg catttctttg
     8341 atatttaagt gcggattacg cagattacac ggattttcaa tcttccgcgt ggtcagtgta
     8401 atccgcactt aactttttct tgtaaaaaca atctcttttt gatagaaaca aacgagattt
     8461 aactaccttt gttggtcgta tgaagattat taactactat ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 ggatggttta atgtattcct gttgatgctg atcttcggtg gtatcatttt ggataagatg
     8761 ggggttcgtt tcaccggaat gggagcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tcttcggatt caaaacacag
     8881 gtaaccctgg ctgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca aaattatcgt gaaatggttc aagggtaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgactttt tcggatctac ggatgagagt ggcacattcc ataccaatat tcctgctccg
     9121 attctgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagagggat tggagccgga agagccgttc
     9241 cgtatgaaag atattgtgta tatcattacg aataagggat tctggttgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtatttccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata atgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtatcggtaa gggagctacg
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgttcgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactatcatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtact
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatggctat ttttgctctt tttggtgtac ttgctctgat tgtggctttg
     9841 atgttgaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactaggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacagaa
     9961 gagtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 aaatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgtata taggaactta ttattattta tttgataaat
    10381 acagcccaaa gtatgacggc aattgctatc aggaccccca tgataataag cgttccccaa
    10441 acaaaataat tgctgtcttt ctctttcttt ttctccgagt cgtggatgat acgttccatt
    10501 tcttcggggg tggtgttggg tagtggataa ggttcgtttg cacggtttaa atgcttcaac
    10561 ttatcgttag cacgttcacg acgtaggcgg gaagcttccc gtccctcttt tattcggcgt
    10621 atcatgtcga atgcatgtcc ttcaccaacc atattctttg ttttttagaa gttcacttcc
    10681 tcatttttct atttcccttc ttctctgtcc actttgagca atcctcccgt attcggatca
    10741 aaataaactt tgatggtaga attcttgttg aacaaaaccg gagccagata ttctatcaca
    10801 ccaaattgag taataggaag ctcaccttcg taaagtttct ttttaccgtc ggtcagtgta
    10861 accatagctt gtccggggac gttgtaggcg attccatcca aatctttctt cttcttaccg
    10921 tcttcctgtg gcatcttgac cgatttcagg tctttcagac tgatataaaa cggagttcct
    10981 gccaaatcat tgttggcaac tacacctaac ttcttcgaga agcggaaagc aacttcattg
    11041 ttgaattcct tgtcaggggt aaggcggaca gtgaatgttc tttcttcttt gttgcaggtg
    11101 ccggagaaca tttgcgtcat ggcttcttcc tgtgcattca gattgtcgag cataatctta
    11161 agctgtgctc cgtctgaagg catattatca gcctgtccgc gcaataaggc atttttgctt
    11221 tcgcggatgt tatagatctc tttagccacc agctcggcca tcttagcggt ggaactagcc
    11281 atcagaatct cttcggtcag gaattcgcga ggattcgctt tcttttggag gactgcgggg
    11341 gcgggagcag cttttttgcc tgcactgcta ttgctgtaag gaacattgat cgttttcaca
    11401 atgccatcct ctgtcagttc catgagcggt gctactgtct tatccttcaa ttttacgaaa
    11461 tacgtagttt cgctgttggg cacacctacg gatttcactt ttacgctagc cagttcccag
    11521 tactcttcag ggtcggcgga gacgttggtc agtcgtaggt aacgatcagc atatttgctg
    11581 aattctcccg gagtatagtt gactttgttg gcttttattt caagttctat ttgggttttg
    11641 ggaagactgt aaaccactcc atagtctttt cctcgggtaa cccctgtcag tacttcggtt
    11701 tgtgcatagg cggacgttgt cataagtagt cctgctgcta taatcaactt tttcatattc
    11761 ggttcttttt aactggtttt gaaaacaaag ttaatgaagt tattgaaaaa agggtaagtt
    11821 cttaactttt attcgcttac aagtcgccat gctgtcggca aacaggtgat aatatcgctt
    11881 gcgatcattc cgatcattcc ttgcttcttt tgagcgacat cgcccgccaa tccgtgaatg
    11941 taagtgccga ttttagcggc ttcctcggtg gggtaacctt gggcaagcag tgccaggatt
    12001 actccggtca gtacgtcacc gctacctccg gttgccattc ccggatttcc ggttgggttg
    12061 aagaaacatt taccttcggg ggtgatgatg gcggagtagg ctccttttaa aataatgtga
    12121 acatgggcgg cacgggccag ttcgcaagcc ttcatcagac gttcgtaaga gtcctggcat
    12181 ttgccggtca gacgttccag ttctttcgga tgcggggtga ggatggaacc cttcggcagg
    12241 tgggtaaggg tatggcggtg gttggcaagg atattaagtg cgtcggcatc cactacaaca
    12301 ggagtctggc aatgttccag ttgctccaat aaagcagctt ccgtttcctc gtttcgtccc
    12361 agtcccggac cgatgccgac tgcttgatag tcgtccgtgt cggtaggtac ggcaaaacag
    12421 gtttcgttga tgtcggtttc tacgattgct tcgggtatgg aggtctgcaa gatgtcgttg
    12481 ttgcacattg gtgcatgaac agtcagcaac cctactcccg aacggaggca ggcgcgggca
    12541 gcgagaacag aggctcctgc cattcctttt gaaccggcaa tcaatagtgc atgaccgaag
    12601 tttcccttgt gggcaaactg tttgcgtggc ttgatgagtg aacggatttg ctctatttcc
    12661 aacatttcgt agttcgtttc catctcttca ataccgtctt cgctcaattg gatatccaac
    12721 aattcccatt ctccgacaaa ttctgtgttt tctgcgaaaa gaaaggcgag cttcggcagt
    12781 tgcagactga aagttacgtc ggcacggata atattagctt ttacgttgaa tgtattttct
    12841 tctcccatca gtccggaagg gatgtcgatg gctactacca tggcagggga ggaattgatg
    12901 tatttcacta cggcagcgaa tccgccgctc aacggtttgt tcaggcctga accgaataat
    12961 ccgtcgatta ccagatggtc gggcgtcagg gcgggaggta cgaattgggt actgatctcg
    13021 tggaatttta cttcttccat catttctacc agttctttat tggtctggca gtcgggtgaa
    13081 agttctcctt tcgtgttgaa gagaaatacc tcgattttat atcctttttc agccatcatg
    13141 cgggctacgg cgagagcgtc tccgccatta ttccccggtc cggcaaagat agtgaccggc
    13201 gtttccgtat tccatctgtc tgtgatggct tttgttaata cggttgctgc acgttccatc
    13261 agatcgattg atgcaatagg ttcgttctca atggtataag cgtccaattt cttgatactg
    13321 ctgcttggaa atattttcat tgcgatgttc ttttagtttt cggattacaa atgtacatga
    13381 ttcttctgac ttttcccgtt tgttgtggga agaaaaccat aattgcaact tttaattcat
    13441 cattagttct atctttgggt cagagaaata tctgcttttg aactattaag tgttagaata
    13501 actccgccaa aaaataattc aatgcagcac cattatgaac ttacttttat ttctcctgaa
    13561 aaagatttct ggttcttcgt caaatttggt ggtaaattct ttatctcttt atttccaagt
//
