LOCUS       gnlProkkaGIGPGPPK_44   13770 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GIGPGPPK_44.
ACCESSION   gnlProkkaGIGPGPPK_44
VERSION     gnlProkkaGIGPGPPK_44
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:28:12
            Original ID  :: gnl|Prokka|GIGPGPPK_44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13770
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13770
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3419:3770]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3420..3770
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13770
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             264..1775
                     /locus_tag="ctg24_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1849..2916
                     /locus_tag="ctg24_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             2953..3237
                     /locus_tag="ctg24_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3420..3770)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_4"
                     /sec_met_domain="PqqD_RRE (E-value: 3.8e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.4e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(3868..5256)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5504..5899)
                     /locus_tag="ctg24_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(5906..6679)
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETIKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6685..7212)
                     /locus_tag="ctg24_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7199..8440)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 387.1; E-value:
                     2e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg24_9"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8450..9544)
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9549..10589)
                     /locus_tag="ctg24_11"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGEASKE
                     AEQTNK"
     CDS             complement(10608..11642)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_12"
                     /sec_met_domain="PF04055 (E-value: 5.3e-18, bitscore: 57.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDNLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
ORIGIN
        1 agaagaagta ccaccaaatt tgacgaagaa ccagaaatct ttttcaggga gaaataaaag
       61 taagttcata atggtgcagc attgaattat tttttggcgg agttattcta acacttaata
      121 gttcaaaagc agatatttct ttgaccaaaa gatagaacta atgatgaatt aaaagttgca
      181 attatggttt tcttcccaca acaaacggga aaagtcagaa gaatcatgta catttgtaat
      241 ccgaaaacta aaagaacatc gcaatgaaaa tatttccaag cagcagtatc aagaaattgg
      301 acgcttatac cattgagaac gaacctattg catcaatcga tctgatggaa cgtgcagcaa
      361 ccgtattaac aaaagccatc acagacagat ggaatacgga aacgccggtc actatctttg
      421 ccggaccggg gaataatggc ggagacgctc tcgccgtagc ccgcatgatg gctgaaaaag
      481 gatataaaat cgaggtattt ctcttcaaca cgaaaggaga actttcaccc gactgccaga
      541 ccaataaaga actggtagaa atgatggaag aagtaaaatt ccacgagatc agtacccaat
      601 tcgtacctcc cgccctgacg cccgaccatc tggtaatcga cggattattc ggttcaggcc
      661 tgaacaaacc gttaagcggc ggattcgctg ccgtagtgaa atacatcaat tcctcccctg
      721 ctatggtagt agccatcgac attccttccg gactgatggg agaagaaaac acattcaacg
      781 taaaagctaa tattatccgt gccgacgtaa ctttcagtct gcaactgccg aagctcgcct
      841 ttcttttcgc agagaacacg gaatttgtcg gagaatggga agtgctggac atccaattaa
      901 gcgaagacgg tattgaagag atggaaacga actacgaaat gttggaaata gagcaaatcc
      961 gttcactcat caagccacgc aaacagtttg cccacaaggg gaacttcggc catgcactat
     1021 tgattgccgg ttcaaaagga atggcaggag cctctgttct tgctgcccgc gcctgcctcc
     1081 gttcgggagt aggattactg actgttcatg caccaatgtg caacaacgac atcttgcaaa
     1141 cctccatacc cgaagcaatc gtagaaaccg acatcaacga aacctgtttt gccgtaccta
     1201 ccgacacgga cgactatcaa gcagtcggca tcggtccggg actgggacga aacgaggaaa
     1261 cggaagctgc cttgttggaa caactggaac actgccagac tcctgttgtg gtggatgccg
     1321 acgcacttaa tatcctcgcc aaccaccgtc atgcacttac ccacctgccg aagggttcca
     1381 tcctcacccc gcatccgaaa gaactggaac gtctgaccgg caaatgccag gactcttacg
     1441 aacgtctgat gaaggcttgc gaactggccc gtgccgccca tgttcacatt attttaaaag
     1501 gagcctactc cgccatcatc acccccgaag gtaaatgttt cttcaaccca accggaaatc
     1561 cgggaatggc aaccggaggt agcggtgacg tactgaccgg agtaatcctg gcactacttg
     1621 cccaaggtta tcccaccgaa gaagccgcta aaatcggcac ttacattcac ggactggcgg
     1681 gcgatgtcgc tcaaaagaag caaggaatga tcggaatgat cgcaagcgat attatcacct
     1741 gtctgccgac agcatggcga cttgtaagcg aataaaagtt aagaacttac agttttttca
     1801 ataacttcat taactttgtt ttcaaaacca gttaaaaaag aaccgaatat gaaaaagttg
     1861 attatagcag caggactact aatgacaacg tccgcctatg cacaaaccga agtactgaca
     1921 ggggttaccc gaggaaaaga ctatggagtg gtttacagtc ttcccaaaac ccaaatagaa
     1981 cttgaaataa aagccaacaa agtcaactat actccgggag aattcagcaa atatgctgat
     2041 cgttacctgc gactgaccaa cgtctccgcc gaccctgaag agtactggga actggctagc
     2101 gtaaaagtga aatccgtagg tgtgcccaac agcgaaacta cgtatttcgt aaaattgaag
     2161 gataagacag tagcaccgct tatggaactg acagaggatg gcattgtgaa aacgatcaat
     2221 gttccttaca gcaatagcag tgtaggcaaa aaagctgctc ccgcccccgc agtcctccaa
     2281 aagaaagcga atcctcgcga attcctgacc gaagagattc tgatggctag ctccaccgcc
     2341 aagatggccg aactggtggc taaagaaatc tataacatcc gcgaaagcaa aaatgcctta
     2401 ttgcgcggac aggctgacaa tatgccttca gacggagcac agcttaagat tatgctcgac
     2461 aatctgaatg cacaggaaga agccatgacg caaatgttct ccggcacctg caacaaggaa
     2521 gagagaacat tcactgtccg ccttacccct gacaaggaat ttaacaatga agttgctttc
     2581 cgcttctcga agaagttagg tgtagttgcc aacaatgatt tggcaggaac tccgttttat
     2641 atcagtctga aagacctgaa atcggtcaag ataccacagg aagatggtaa gaagaagaaa
     2701 gatttggatg gaatcgccta caacgtaccc ggacaagcta tggttacatt gaccgacggc
     2761 aaaaagaaac tttacgaagg tgaacttcct attactcaat ttggtgtgat agaatatctg
     2821 gctccggttt tgttcaacaa gaattctacc atcaaagttt attttgatcc gaatacggga
     2881 ggattgctca aagtggacag agaagaaggg aaatagaaaa acgagaaagt gaacttctaa
     2941 aaaacaaaga atatggttgg tgaaggacat gcattcgaca tgatacgccg aataaaagag
     3001 ggacgggaag cttcccgcct acgtcgtgaa cgtgctaacg acaagttgaa gcatttaaac
     3061 cgtgcaaacg aaccttatcc actacccaat accactcccg aagaaatgga acgtatcatc
     3121 cacgactcgg agaaaaagaa agagaaagac agcaattatt ttgtttgggg aacgcttatt
     3181 atcatgggag tcctgatagc aattgccgtc atactttggg ctgtatttat caaataaata
     3241 ataataaatt caccacagag gacacggagg acacagaggt ttaatctttt ttattcacta
     3301 tagagtaaca cagagtctca cgtattgaga atcgtattta tcgctctgtt ttacttgcgg
     3361 aaagagagag aagaactctg tgtcctccgt gtcctctgtg gtgaaatata aattcctatt
     3421 tatgcgactg gtatcaccag ttttataaat ccatctttct gcatttgaga aagataagcc
     3481 gatacacgcg actcgtagcc ctcttcattt tgaaaatggt ctgcgagttt ttctataatc
     3541 tcacgaacat tgcgttttcc atctatcagt tcccatacag ccgtaccgtg ttcttccaat
     3601 ttcacatgaa gttctttcga cattcctttc ggcacaagga agcgttgcat ccacggatat
     3661 ttaaaacggg gaaaggagag cacaattgtc tccccttccc tttctgctgt aatatgttca
     3721 ctgcgacagg gaatgacctc taacaggttg attttctctt tggcagccat acttcttatt
     3781 ttttatttca gagtattcat actgataccc ttttgtttac accttgatac aaaattcctt
     3841 tgttacttta ggtattgaat ttcccagtta cttttggata ttcgcctctt ccagaccgta
     3901 tcccttcttc ttgttctctg ccttcaacat caaagccaca atcagagcaa gtacaccaaa
     3961 gagagcaaaa atagtcatcg gcaacgtgta gtcataagtc tgtgcaccgt ctactaccgg
     4021 acctttgcaa taagtattca acacccatcc gatcaacaaa ggaacaccca tcaatcccca
     4081 gttctgtacc cagaaaatca atgcgtatgc ggtacccaac tgtttttccg gaataatctt
     4141 cggaacagac ggccacatag ctgaaggcac caacgagaag gcaaatccca atataatcat
     4201 gatgatagta gcaaaccacc atatattcag tataggcaga gcaaacatcg tatgcacaaa
     4261 aataagcatc actgatccga ttatcatcaa tgtggctccc ttaccgatac ggtcataaag
     4321 cgaaccgaac aacggagtca ggataatcgc accaatcggc aacaatccgg gaatcgttcc
     4381 cgccaacttc ggatctacgt tatatttctg caccatcaag tcggcagcat acttgataaa
     4441 ggggaataca gccgagtaga acaatacaca tagtaatgca atcaaccaga atcctttatt
     4501 ggtaataata tacacaatat ctttcatacg gaacggttct tccggttcca atccctctgc
     4561 atccaaagaa gcatccaact tcttatcata gaaagtataa aggaaaaaag caatcgtacc
     4621 cacgcacaac ataatcagac aaaacaaaat cggagcagga atatttgtat ggaatgtgcc
     4681 actctcatcc gtagatccga aaaagtctgc caaaggaact gtcaatacca tcgccagagt
     4741 tgttccgata cgtgccgtag ccatttcaag tcccatagcc aatgccattt ccttgccctt
     4801 gaaccatttc actataatct tggaaacagt gataccagca atctccacac ctacaccaaa
     4861 gatagcatat cccaatgcag ccaacgtcac ctgtgttttg aatccgaaga gcatggcacc
     4921 ttccggaaaa gtagtagaaa tcgcatagta tttcaatcca caaccaaaca ccatcaataa
     4981 gcaagccccc attccggtga aacgaactcc catcttatcc aaaatgatac caccgaagat
     5041 cagcatcaat aggaatacat taaaccaccc gtaagcactt gtgaagaaac cataatcaag
     5101 actgtcccat agtagttctt tctcaagcat gggttttaga ggagacatta cgtcggtgag
     5161 gaaatagccg catagcatag taaatgcgac caatgctaga acactccatc ggagtacggc
     5221 ggagtcattc aatttctgtt tcaaatgttc tgtcattgtt atatttaaaa aagtagttaa
     5281 taatcttata cagccaacaa aggtagttaa atctcgtttg tttctatcac aaagagattg
     5341 tttttacaag aaaaagttaa gtgcggatta cactgaccac gcggaacatt gaaaatccgt
     5401 gtaatctgcg taatccgcac ttaaatatca aagaaatgca gcatccgtct gcaccttccc
     5461 attaatggtt ttaccccaaa gtcttacttg acgacggagt gaattactct gctgcaggag
     5521 caggagtttc agtagccggt gccggagttt ctgtagcagg tgcattggta gcaggagctt
     5581 cagtttgcgg cgcagccgta cctgcgggta agttatacgg gttagtctgt tgttctttct
     5641 gtgcctgttc caacactgcg tctttagcaa cagcagagcg aggaactaca taagcagtag
     5701 caatgctcat tacaaccata aagatggcca ggccccatgt tgctttttcc agaaagtctg
     5761 tagtcttgcg cacgcccatg atggcgttag atgaagagaa accagaagca agtccgcctc
     5821 cttttgagtt ctgaatcagc acgatgaaac acatcaacaa ggctgcaata accattaaga
     5881 taacgaataa taagtacatt tttagttatt ttgaattagc gttaataatc aatttctcca
     5941 aaaatctgat ttggtctgca aagtaagcat ttttttttgg atatttcaag cttaattttt
     6001 taattatttc aagagctttt gaatatcgtt gctgtttaac atagattttt gccaaagttt
     6061 ccgtaaaaca gctgtcatct tcctcttctt cctttatcgt ttcttcttcg gtaagttcgt
     6121 ccgaagaggt tggcgaagat ggcatttctt ctcttaaagg tttcatgcag aggggagagt
     6181 cgctctcgct cttttctata aaatcgtcaa tcagttcgaa gcctttgagt ttgggcgttt
     6241 cttcagccgg ctgttccgtg gccggagtct cctccaaaag gaaagaggtg taatccatcg
     6301 aatagtcgaa actggtccgg gcagtcacct cttcgggtac tgtggacaag aaagcgtcga
     6361 tcaatgctaa tgtgcggtct acggacggtt cgtctttcag cacctccgtg agaggtactc
     6421 cctttttccg cgcctgcaca tcatagcggt caccttcaat caaccggaac aactgccgtc
     6481 tgtctgcaat gtaaagaact gctttccgca gttctccacc gaaactaata tcatggagaa
     6541 tatacagatt cttcagatac aacagacgaa gtgactgaaa atacggatac ctcgcaagaa
     6601 gattgcgcag ttcgtacaaa gtatccctat tcagcgtctc gggatgctga atccattgtt
     6661 gaaagttaac agaagtcatt tatattacca gtttgctaca gttgcattaa aaatttggtc
     6721 ggtgatctct ttagacattt cagcaatcaa tccgtcctgt acggcagtca acaactgggt
     6781 agagtcgtag gtacggaacg cagaaaactg ttgttcaaag tcttcggcat gattggtgtt
     6841 gttgacaaaa cgcacattga cggtgatagt caacttcgtc tccgaagaat aaccgtcggc
     6901 agatactgcc tggttgtact gattgtaccc tgtgatttct ccgtcaatct gcaagtcggc
     6961 attttgactc ggcttgagca gttgcagacg ggtctgccgg atgaagatat ctttcaggtc
     7021 ctcattgaat ttggttgcca acggagcata tacatactcc gacttgatcg ggaagtcggc
     7081 tatcgaaatg gtctttacct tatcataatt gatagacgat ccgttaaact tataggaaac
     7141 agtgcacgca atgactacca acggcaagcc gaacagtagc aaagggcgta ttattttctt
     7201 aatccaattc atattctttt atttttctat aaagtgtacg ctcggaaata ttcaagtcct
     7261 tggccgcact cttccgcttt ccatgatgcc tctcaagtgc cttgcgtatc atttctttct
     7321 ccacttcgtc cagtgacaaa ggagattctt ctacatattc ttccgtgtct tgtatgtcat
     7381 cgtcatcctt gcaaaccgta ggctgcatgg tgtgaatgat agcaggtacc gaaggttgat
     7441 gtgccgtcac taccggagta gtaaccaccg ttcccatttg ccctacctgc cccacctgtc
     7501 cggcacgttc cgccatcagg ttgtgcacca tcttcttcag ctccgccact tcctggcgca
     7561 tatcgaacag aacagaataa agaatctccc gttcgctctc aaagccttta ctctcacgcg
     7621 ttcccatcag cgcgggaaga cgttgcgtat tttgtgcagg aagataattc tgcaagatag
     7681 cagcagagat ctccctgttg gtttcaatga tagatatttg ctcggtgatg ttcttcaact
     7741 gacgaacgtt gccgggccac gggtaagcca ataactcttt cttcgcatcc tccgtcaact
     7801 ggatagcagg catccggtat ttctctgcaa agtctgcgga aaacttacgg aacaacaaaa
     7861 gtacatcgtc accacgttca cgcaaaggcg gtatttggat aggcaccgta ttcaaccggt
     7921 aatataaatc ttcacggaaa cgtccttctg caatcgcttg tgtcagattg acattggtag
     7981 ctgccacaat acgaacatcc gtcttttgca ctttggacga acctactttt ataaactcgc
     8041 cactctccaa cacacggagc aaacgcgcct gggtaggcat cggcaactcc cctacttcat
     8101 caaggaaaat agtaccaccg tcggcttcgc caaaataccc tttccgttcg ccaatcgcac
     8161 cggtaaacgc acccttctca tgcccgaaca gttcggaatc aatcgtgccc tccggaatag
     8221 caccacagtt gacagcaata tactgtccat gcttcctccg gctatattga tgaataatct
     8281 gcggaaaact ttcttttccg actccacttt ctccggtaat cagcacagac aaatcggtag
     8341 gagctacctg aatggcaaca tctatggcgc gcgacaatgc ttcggtatta cctataatac
     8401 cgaaacgttg tttcacttgt tgtatctctg ctctcgtcat cactcgtttt taatcttcgt
     8461 ctactgtatc cagcttcagt ttatcactat cgtcacgttt ctcgtaatac tgtttacgca
     8521 acggattggc acgagccact ttttcccgct gacgattacg gaacacatcg atggcaacat
     8581 agattgcctg acggaaagaa tcttcacaag ccaatccctt gcctgcaata tcgtatgccg
     8641 ttccatgagc cggagaagta cgtactaccg gcaggcctgc cgtatagttc accccgtctt
     8701 ccatagccaa ggccttgaac ggagccagcc cctgatcgtg atacatcgcc aggataccgt
     8761 caaaatgagt ataattgcct gaacccataa agccgtcggc cgcataaggg ccgtagcaaa
     8821 ggattccttt ctcttccatt tctttcatgg cagggataat cacttcctgc tcttccattc
     8881 ccaacaaacc accgtctccg gcatgaggat tgagagagag caccgcaata cgcggagcgc
     8941 cgataccgaa atcctgtttc aggcaacgat ggaatatcat cagtttctcc tgaatcagtt
     9001 ctttggtaat cgtagtcgcg atctctctga cagggatatg tgtcgtcacc aaagccaccc
     9061 ggaagtcatt cttcatcaaa atcatcaatg acttatcacc attgcccaga cgttcttcga
     9121 tatattccgt atgtccgggg aaggagaact cttccgactg aatcgtatgt ttgttgatcg
     9181 gagctgttac gataacgtct atcagccctt cgcgatattc ttcgatggca cgttccaaag
     9241 cccccagcgc agctttaccg gcttcggggt cgggtttgga aaattccact ttcacctcat
     9301 catccgtaca gttcaccacg ctcaaacggt tgtaccccgc ttcggtagca gagttgacaa
     9361 tgctgaaatt ggtctgtata tccagcgctt tgcgatgata agccgctact ttcggtgagc
     9421 cataaatgat cggagtacat agttccaaca tcgtagggtc ggaaaatgtc ttaagaatca
     9481 cctcatagcc caccccgtta atatctcctt gggtgatacc tatccttatc ttgttatctt
     9541 ccatgttttt atttattagt ttgttccgct tccttagatg cttctcccaa tggaatctga
     9601 ttctgctgaa cttcattcgg aagtttcagt gtatacagag atgcttccat ctggcgtacc
     9661 aggttgcgtt tcattttatc aggtgaataa acaaatattt ctgctgttat aattcgttgg
     9721 tttttctcgt ccagacgagt atgagataca tacgggccac ccataaagtc gcccttcata
     9781 cgccacaggc cacgtgcttc cattgtgtag ctgttttgta cattgatcgg acggacatcg
     9841 gtcagcaaac tatcggtcga catataaacg ccttccttga atccggggat attggctttc
     9901 atcacggagt cacgtttgtg cacaaaatat tctttggtaa acgtatcctt gtcagtgtac
     9961 ggataagagt acatcacaaa gttacggtca gcactacctg tgttggtaga agcccagaag
    10021 aaatcatccc cggtctttga attagccagt tcggcatcca cccagatgtc gcatccgaac
    10081 aaactgtcca ctttctgcga aatgaaatta ctgtgtttcc cttctagaaa cgtaatctga
    10141 cggttcattt ccgcacgggt aaagaagtcg acaatcgtct ttttgttctc ttccacaaac
    10201 ttctcgaact cttcttcgtt cggagcctgg atagtcaata tcatctgcgg attggcatac
    10261 acgtccttcg catatttgaa cgaggctttc gtatatatat cctgtatatc tacaataata
    10321 atgttacgta tcaacttcag cgtagaatca taatctttcg gtgaagtata cataatccgg
    10381 aaagaaggtt ccgactgcgg caaaccgggc atatcagcat cgagcgcatc atgcaacgcc
    10441 cttccggcag cacgatccca aacaccgtga tctactacaa ccaaaagctc gtaagcacga
    10501 ccactagagg tgtgatttcc tttcagacca caagatgcaa cgacaaaggc taccaaagcg
    10561 atgcataaaa taaaagagta ctttttcatg atgttcggtt ttatatatta actttcatta
    10621 tttttctcct gtttcgctgt cgacagcata ccgcaagcgg caaaaatatc ttcgcctctg
    10681 gatgaacgga tagtggtgaa aagtccgtgt gacgtcagat tatcacgaaa acgggtcatc
    10741 gtatccatat ccgccccctc gaggtctacc cccggtatgg catgaaaacg aatcagattc
    10801 accctgcaat ccagcccgcg aagaagtttc agcaactctt tggcatagac ctgcgaatca
    10861 ttgagccctt taaaaacaat atattcaaac gaaagtcgac gttgtttact aaaatcatag
    10921 ttttttaaca gttccaccat ttcggtgatt gaaaacgcct tttccgccgg cattaattca
    10981 gcacgctgaa cggtcagcgg agagtgaagg ctgatggcaa ggtggcagtc attttcttcg
    11041 ataaaacgct gcaatccttt ccgtagcccg acagtagaaa gcgtgatacg cttcggactc
    11101 catgcgtaac cgtaggtagc ggtcagtagt tccaatgctt tcaatacctc atccaggtta
    11161 tcgagcggct cgcccattcc catcattacg acattagtca gtttgtcccg ttccggcagc
    11221 gaatgaatct gattcatgat ctggctggcg gtcaggttag ccgtataccc ctgtttgccg
    11281 gtcatacaga acttacagtt catcttgcaa cctacttgtg acgacacgca caacgttgcc
    11341 cggtcatcat ccggtatata aaccgactct acaaaatggt tctcacccac tttataaaga
    11401 tacttcaccg taccatctac agagcgcatt tcatctaccg gagcttctgc tcccacctca
    11461 tagttctgct tgagcaactc ccggtgtttc aatgacaaat tagtcatatc atcaatcgag
    11521 gctaccttct tttcgtaaag ccaggatgca atctgcttgg cagcaaagcc gggcataccc
    11581 agtctttttg tcaatgattg aagctctaca agagtcattc ctaaaagggg atatttagac
    11641 attcttcttt ctgttgatag tttatatctg caaatgtaag gaaataaagt cgatttccgt
    11701 atagcaggaa tgtaaaagtt aacaaaaaag ggaagtatgc ctccgttatg attcaaccac
    11761 gctgatatat tgaagtagct tttgcgccat ttcagaatcc tcgccattct ttttcacttc
    11821 atgaccgtac gcctcacgga aacaagccag cgcctcttcc cgttcattac aaaagctgtg
    11881 caaaacccct aagttctgac aagccagaat cgtatcttct tcctcccatc ccaaatactt
    11941 ctttcgcagt tcgaactctc tgaagaaagc ctctttcgcc attggataat tctccaactt
    12001 cacataagcc tgtgctttgt aataatatac cagacaggaa gcattagggt cagcatcatc
    12061 gtgaatatcc aaagacgtcg caatacgaat cacgttatca tagtctttat tcatgtaata
    12121 ctgctgcata atatcacatc tcaatgcctc atatcggaca gtcagttccg ccagacgcgg
    12181 tttttcgctg aaatacattt catgcagaag agactcacgg aagaataaag tagacgcctg
    12241 ctcatcgcca cgttcattca tcactcgttt gaattccctg cacagataat acaactgttt
    12301 atgacaagcg acgatctgtt ttttattatc tatctgtata gcaatgtcca acgcctgatt
    12361 catcagcatc catgcttcat cgtatcgttt gatataataa agacatttac cctgcatacg
    12421 caaacattta gccactccac cggacagtct gccattcaat gactcgtgca tttcagctac
    12481 tttccggaat ttctcggcag cactctcttc ctcatcctta tagtaatcac aataagccag
    12541 atattcggaa agttcaatga cttctgcctg actcttctcg tcagcaaaag ccgcatgata
    12601 atcaagcgcc ctattcaaat agatcgccgc ttcattgtat tgctcattgt agtaatatgc
    12661 caaagctaga tttcgacagg tgttggcaat ctccagttcc ggagtcggta ctatgttttc
    12721 ctgcatcacc aatgctttca ggaaacagtc gcatgccgtt tcgtattctt cattacgggc
    12781 ataccggcat ccctcattca tcttcaatac cgacttggct attagtggca tggcagcacc
    12841 ttccatactc ttctcactca cagcagctgc cgccttcgtc agatggaaag aactgctcaa
    12901 gaaagtagcc atatcattag caatgacagg aattaaaaaa gaatcgatct catcaaagtc
    12961 caattcggca tagacttcag gcgtaacttc aggattgtcg ttcatgatcg ccttccagct
    13021 atcttccaac agagaacgat tcgtgcgata cagaatctcg aaaatctcca catcacaaat
    13081 ccaatccttc aatatatccc attcttgcat cttatagcat tgataggtaa tctccacttt
    13141 atagcgatac gaatcatggt agcagaactg tttcatgcga tagttataat cggcaaaagt
    13201 caacggatgg gaaaggatct cttcctcatc cagcagagcg gaaataattt catggcgact
    13261 atcatctata cattcgtcat cttgagcgaa atagcgttcg atcgcctcta ccatttgtgt
    13321 gtcaccaatg caatatcgtc ctcctttgtt ggtgagccag ctgctcattt ccactctcaa
    13381 ctgcgaccaa agtatctgat taatgtctgc catgctcttc acttcatctt cggtaaatcc
    13441 ttctaaagta agtgaaagca tcagaagcgt tcttccaatc tcttcggaac cataatcagc
    13501 cgacaaacgc cgtagcacac tgtcatagaa ttgcccaacc tcattgagcc ggcaatatcc
    13561 acgcatatat tcattgagag catcgtactg accgaacgaa accagctcgt tgagcaatac
    13621 actcaaacag cgcggttgtt tagccagcac ccacgaagca agaatatctt cctgctgtgc
    13681 agacaaagcc ttggagtaag tagacaaata ttgctttgag aacgacttgg catccgcctg
    13741 tgaaaagcca ttcaactgga aatgagcata
//
