LOCUS       gnlProkkaHIGDBMJJ_78   13521 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HIGDBMJJ_78.
ACCESSION   gnlProkkaHIGDBMJJ_78
VERSION     gnlProkkaHIGDBMJJ_78
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 10:06:36
            Original ID  :: gnl|Prokka|HIGDBMJJ_78
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 162623
            Orig. end    :: 176144
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13521
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8521]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8521
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13521
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13521
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(495..1460)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_127"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.4e-27,
                     bitscore: 88.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKISVIIPVYKVEQFIERCAISLFEQTLDDIEYLFIDDCSPDNS
                     VEIIKNVLMRYETRKDSVRIISMQKNCGQAAVRRYGNSIARGDYIIHCDGDDWVDINMY
                     YKMYECAVNNKLDIVRCKFCRTDGKLMKECINIPSNIYCDAKKMISYLLRLSDLSSTCD
                     KLVRRELYQSVDFIYPVDNMCEDFAIVTQLFCRTDKIGYIDEVLYFYYQNKFSISHILD
                     NTHIDNKAQQISNNVKLIGKILKTKYPGGIFDKEIEVIKLMAKNAYRPIIRREGYYEKW
                     KTLYKEINSKIFFNEYITIKEKLSFIACYIGIYPLLTGRK"
     CDS             complement(1462..2478)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_128"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.9e-27,
                     bitscore: 87.5, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKILSVVIPSYNMEEYLYRNVSSMMIGEILDDLEIIIVNDGSKD
                     RTSEIAHELQRKASQSIVVIDKENGHYGSCVNAALKIATGKYFRILDADDWMDSGEFVK
                     FVNILKCIDVDCIYTPFANVFFNKNRKEYCIADNAVWNKKIDLSHVSLPPSYFHMHSLT
                     YRTHLLHKISFVQEEKICYTDSEYVFYPLSHAKSLYCINVCPYQYYIGREGQSVSLDSL
                     SKNYAHFEKVLANISFYKPMELLPTYSSLRKYYIVTLLRYMLDIHLFSQKKDVQRDKLL
                     RDKIRAFGDDVNISEQIKDINLKGLHYINWWLDNTGVDKLKLKILVLLKKVQHTIVN"
     CDS             complement(2493..3920)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_129"
                     /sec_met_domain="Polysacc_synt (E-value: 7.9e-39, bitscore:
                     126.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDKAVNGVFWTSVERIGSQVLSLLVGIAVARILSPEDYGIIGMT
                     AIFLAVASTLLDSGFGSALIQNQNRTETDYSTCFYFNIVVGLFWYVVLFLAAPLIADFY
                     RTPLLESVCRVLGLVFVFNSLTISQTARLTVEFRFRELCFVTLGTQLLTGIVGFIMAFK
                     GYGVWALVFQQVGAAFLRVCLIEWITHWKPLPLFSKIAFCRMFSFGSKILCSGIINTVY
                     DNIYTLVIGRVFSPVEVGFYNRGNQFAQLPSQSLLSVVMKVVYPLMAEVQDDSEKLCRA
                     YQKFLRISVFILYPILIGLIVLAESFIYVLLGDKWLPCVPLMQILCFSYLFDPLTHINL
                     NILYVRGRTDLVLKLELIKKPIALIILFGMLPFGLWWLCAGRALYSFIAYCFNCFYTGK
                     FIRFGFRQQMYYSVPVIVKSALMGIICWRTALGFEEPWLKLMVGFLAGLLSYIGLNFIS
                     HDESFFDIKGIILKNGK"
     CDS             complement(3945..4925)
                     /locus_tag="ctg78_130"
                     /transl_table=11
                     /translation="MTQYINSLEEEMRSGFLVTRQSKHVWNIQIEMTLALLEVCKKYNL
                     RIWAISGTMLGAVRHKGFIPWDDDMDFFMFREDYDRLLEIASDEFKKPIFFQCAYTEKG
                     YYRGHAQMRYDNTAMILLYEGEIGVKFHQGIFIDIFVADGFPEDKEEREQLIEQRNCIL
                     NYLWGRNYPLRRFSSIPNLIKYISAKRKLGEKASWTDIELYSYMEQLHRNYSVNRNSRN
                     CCIQFTYLPRYVRNTEWFDETVWIPFERIELPVPLAYHEVLKHEYGDYMKPIKGASLHG
                     NLVVDVDESYEKYLSGLKMSFLKATYLFIKSGGGMVLRVFGLRKK"
     CDS             complement(5001..6092)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_131"
                     /sec_met_domain="Fe-ADH (E-value: 9.8e-67, bitscore: 218.3,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIYQGIDYLNEALKGSTKVLLVCGSSFPYLGIKDKIEHIGTPF
                     MVFDQFTSNPLYEDICRGVDLFQITQCDTILAIGGGSSMDVAKCVKLYCQMSKDKPYLQ
                     QEYKDTGVKLIAIPTTAGSGSESTCYAVIYHDGKKQSVMHKSIIPDVVILEPKLLKTLP
                     VYQKKCTMLDALCQGIESWWSVNSTDESKRYSKIAVETIIKYWREYIFENTDFSAEQIM
                     LAANYAGRAICITQTTAAHAFSYKITSLYKLPHGHAVAVGLSEIWEYMLLNMNKCLEPR
                     GEEYLWGIFADISKAMGCLTLEQAVVKFRQILTEMEITNPVAINKTEEIEILSHSVNPV
                     RLKNNPVELCEFTIKSLYEIIIK"
     CDS             complement(6104..7228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 62.4;
                     E-value: 5.9e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_132"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.6e-20, bitscore:
                     64.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-20, bitscore:
                     66.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPKFFIDELDRYGIDYFAGVPDSLLKSICGYIADNMDARHNII
                     TANEGAAVALAAGYHLATGKVGVVYMQNSGEGNAINPLASLVDKEVYNIPILLLIGWRG
                     CPGVQDEPQHVKQGKVTTGLLNIMGVNYDVLSKEENKAAKQILKAVEAVKRNEVYALII
                     EKDTFNAYTLQNVERNNFTMSREEAIQTVVAALGEADTIISTTGMISRELFEYRTAMNQ
                     GHERDFLTVGAMGHASQIALGIALEKQDRKVWCFDGDGASIMHMGSMAIVANKAPQNYV
                     HVVFNNGAHDSVGGQPTVGLKIDIPAIAKAMGYKHVYNVDTKEGLQELIGEIKVQEGPI
                     FLQACVKQGNRKDLGRPTTTPIQNKEALMTFLRS"
     CDS             complement(7238..8521)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 202.1;
                     E-value: 1.8e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg78_133"
                     /sec_met_domain="CTP_transf_like (E-value: 2.4e-13,
                     bitscore: 43.7, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.7e-117, bitscore:
                     384.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.8e-61, bitscore:
                     199.7, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADIIHPGHLNIIHEANKLGRVVVGVLTDSAIASYKRLPYLSFE
                     QRSLIVENLKGVDEVIPQTTLDYVPNLEKIRPNYVLHGDDWKEGVQQKTRQHVIDCISQ
                     WGGKVIDIPYTQGISSSLLNQHLKEIGTTPEVRMKRLRRLIAAKPIVRILESHSGLTGL
                     IAENACIEINNVKREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHGLNDALEVTTKPFI
                     YDGDTGGKLEHFVFTVRTLERLGVSAVIIEDKVGLKQNSLFGTDAIQTQDTIEGFTAKI
                     KAGKNAQITEDFMIIARCESLIAGKPMSDAIERCFAYVEAGVDGIMIHSKEKTGEDIKE
                     FCKKFRARYADIPIVVVPTTYNQFTEEELASWGINVVIYANHMLRASYPAMMNCAKSIL
                     THGRSKEASAEYCMPIKEILELIPSTHK"
     CDS             complement(8642..9769)
                     /locus_tag="ctg78_134"
                     /transl_table=11
                     /translation="MNHYDFLIVGAGLFGSVFAYKAKLQGKKCLVIDRRSHLGGNIYCE
                     NIEGINVHKYGAHIFHTSNKVVWDFVNSIVEFNRYTNSPIASYKGKLYNLPFNMNTFYQ
                     MWGITTPAEARAKIEEQKAEAIALMKEQGVIEPRNLEEQAQLLIGKDIYESLIKGYTEK
                     QWGRKCSDLPAFIIKRLPVRFIFDNNYFNDKYQGIPIGGYNVLIERLLEGIDTKLNYDF
                     FAHRNELEEISDRIVFTGAIDEFYRYRFGKLEYRTVNFETELLNMSNYQGNAVINYTEK
                     EIPYTRVIEHKHFEMFGADIEACSKTVISKEYSSEWKEGSEPYYPVNDEKNNSLYLKYK
                     KLADQDNNVIFGGRLAEYRYYDMHQIVTKALSHFK"
     CDS             complement(9831..11243)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 294.9; E-value:
                     1.9e-89)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg78_135"
                     /sec_met_domain="Bac_transf (E-value: 2.1e-68, bitscore:
                     222.5, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSTTSQINKFIEFVAVLGDLIILNLVLFFLLFFWEEVFVSLPFS
                     CRVSWMMTSLSLCYLACSGSRGRVWDSRGIRPDQLVLRVLKNIIAFSIFWACIMTFSGI
                     SIYSPLFFVAYFSFLFVILSIYRIIIRHFLIVYCAKGKHRRYAVFIGGGNNMQVLYEEM
                     ESSLASSLYEVVGYFDIKPNEAFSSQCSYLGNPDGFSDFMSVHPGIKHVFCSLSMEEGR
                     YNFSIMNHCENHLLYFHGVPNVCKGFPRRIWHSMVGNMPILNLRYEPLGKMENRILKRI
                     FDIVISGLFLVTIFPFVYLIVGSIIKLTSPGPVFFKQMRTGLNGVDFVCYKFRSMKVND
                     EADSKQATADDPRKTRFGDFLRRSNIDELPQFINVFKGDMSVVGPRPHMLAHTEIYARL
                     IDKYMVRHFIKPGVTGWAQTHGFRGETRELSQMEERVKADIWYMEHWTMLLDIYIIYKT
                     VANVIVGEKNAY"
     CDS             complement(11263..12399)
                     /locus_tag="ctg78_136"
                     /transl_table=11
                     /translation="MSTLMEQTSEKETKQLHNNHNDEEIEIDLMDLLRKVIGIRKKIYK
                     AAGIGLIIGVIVAISIPKQYTVEVTLSPEMGNNKGGGLSGLAASFLGSGVSMGDGTDAL
                     NASLSADIVSSTPFLLELSNMKVPVSGSEKISLSSYLDEESSPWWSYVIGFPGMVIGGV
                     KSLFIEDEDESIFSDKASQGTIELSKKESQKIESLKKKIVASVDKKTSMTSVTATFQDS
                     KVAAVVADSVVKKLQEYIIDYRTSKSKEDCIYLEKLFKERQQEYYVAQKKYADYMDSHD
                     NIILQSVRTEQERLQNDMSLAYQVYSQVASQLQIARAKVQEEKPVFAVVEPAVVPLEPS
                     GTSRKVCVLAFIFLSVCIVISWNLFGKDFLNKFKEVCA"
ORIGIN
        1 aactatttta tatccttgcc gaataaatgg gttaaataat tcttcaaatt cctcaaaatt
       61 ttcctttata ttacctatcg cttctgaaac cgccaaagat tgcgctaacc ccaatctacg
      121 tatttcatta aaatacaaaa atgttgctac aatgcaatat gcagccacag agataactaa
      181 cataggaggt aaagaaatat aaaacatctt atattcacta tcattacgtc tttttatata
      241 agcatttttt tcagcaataa ccatcatgca taatcctaaa gctataattc caaatgtacg
      301 tggatgaaaa ctaatatccc aataatcaac acaccaaata ttcagcaatg ttccaaatcc
      361 taaaacaccg atagtatata ttgatggaga aaaaatagat ctatcaaact tctgccatac
      421 ataaagaaat aataatatct caaacaaaaa caaagtaatt aaatatatac aattttctat
      481 atttcccata tttactattt acgcccagtc aacaaaggat atatcccgat atagcaagct
      541 ataaatgaca atttttcttt tattgttata tattcattga aaaatatttt cgaatttatt
      601 tccttatata atgttttcca cttttcataa tacccttctc ttcttataat aggtctatag
      661 gcattttttg ccatcaattt aattacttca atttctttat cgaaaattcc acctggatat
      721 tttgttttca aaatttttcc tatcagtttt acattattgc ttatttgttg tgccttatta
      781 tctatatgag tattatccaa tatatgactt attgaaaatt tattttgata ataaaaatag
      841 agaacttcat ctatatatcc aattttatca gtacgacaaa acaattgagt tacaattgcg
      901 aaatcttcac acatattatc aacaggatat ataaaatcta ctgattgata aagttcccgt
      961 cttaccaatt tatcgcaagt tgaagataaa tcagataacc ttaacaagta ggaaatcatt
     1021 ttttttgcat cacaatatat attacttggg atattaatac attctttcat taactttcca
     1081 tctgttctac aaaatttaca cctgacaata tctaacttat tattgacagc acactcgtac
     1141 attttgtagt acatattaat atccacccaa tcgtctccgt cacaatgaat tatataatca
     1201 ccacgagcta tactattgcc atatctacgc acagcagctt gtccacaatt cttttgcata
     1261 gatataatac gaaccgaatc ttttcttgtt tcatatcgca tcaaaacatt tttaataatc
     1321 tccactgaat tatcaggtga acaatcatct atgaaaagat attcaatatc gtctaaagtt
     1381 tgttcgaaaa gactaattgc acacctttct ataaattgtt ctactttata caccggtatt
     1441 attacgctaa ttttaggcat ttcaattaac tattgtatgt tgtacttttt ttaataagac
     1501 aagaatttta agttttaatt tatcaacacc tgtattatcc aaccaccaat taatataatg
     1561 caacccctta agattgatgt ctttaatttg ttcactaatg ttaacgtcat caccaaaagc
     1621 ccttattttg tctcttaata gcttgtctct ctgaacatcc tttttctgtg aaaaaagatg
     1681 aatatcaagc atataacgta gcagcgtcac aatataatat tttctaagtg atgaatatgt
     1741 cggtaacaat tccataggct tataaaaact gatatttgcc aatactttct caaaatgagc
     1801 atagttttta ctcaaagaat ccaatgatac agattgtcct tcgcgaccta tataatactg
     1861 ataagggcaa acattaatac agtataacga ttttgcatga gacaaaggat aaaaaacata
     1921 ctctgaatcc gtataacaaa tcttttcttc ctgcacaaaa cttattttat gtaacaaatg
     1981 agtccgataa gtcaatgagt gcatgtgaaa ataagaaggg ggcaatgaga catgactcag
     2041 atctatcttt ttattccaca ctgcattatc agcaatacaa tattcctttc tatttttatt
     2101 aaaaaaaaca ttcgcaaaag gtgtatagat acagtctaca tcaatacact tcaatatatt
     2161 tacaaatttt acaaattcac cgctatccat ccagtcatcc gcatccaaaa ttcgaaaata
     2221 tttgcctgtt gctatcttca acgctgcatt tacacatgaa ccataatgac cgttttcctt
     2281 atcaataaca acaatacttt gagaagcttt tctttgaagt tcatgtgcta tttcagacgt
     2341 tctatcctta cttccgtcat taacaataat gatttcaagg tcatctaata tttccccaat
     2401 catcatgcta ctcacatttc ggtacaaata ctcctccata ttatacgaag gaataactac
     2461 agataatatt ttgttcatta ttatattatt tatcatttcc catttttcaa tattatccct
     2521 tttatatcaa aaaaactttc atcatgactt ataaaattca gtcctatata agaaagcaat
     2581 cctgccaaaa atcctaccat caactttaac catggttctt caaagcctaa tgctgttctc
     2641 caacaaataa tccccatcaa agcagatttt acaatcacag gtacactata gtacatctgt
     2701 tgcctaaaac caaatctaat aaactttcca gtataaaaac aattaaagca gtacgctata
     2761 aaactgtaca aagcacgtcc tgcacacagc caccataacc cgaatggtag cattccaaac
     2821 aaaataatca atgctatcgg tttctttata agttctagtt taagtactaa atcagtccgt
     2881 cctcttacat acaaaatatt aagatttata tgtgtaagtg ggtcaaacaa gtagctaaaa
     2941 cataatattt gcatcaaggg aacacaaggc aaccatttat cgcctagcaa tacataaata
     3001 aaagactctg ctaagactat taacccaata agaataggat aaagaatgaa aaccgaaata
     3061 cgcaaaaatt tctgataagc tctacaaagt ttttccgaat catcttgcac ttctgccatc
     3121 aatggataaa cgactttcat aacaacagat agcaaacttt gagatggtaa ttgtgcaaac
     3181 tgatttcctc tattatagaa tccaacttct acaggtgaaa agacacgccc tatcactaat
     3241 gtatagatat tgtcataaac agtatttata atgcctgaac atagtatttt agaaccaaat
     3301 gaaaacattc tacaaaatgc aatcttggaa aacaagggta acggtttcca atgtgtaatc
     3361 cattctatca gacatactct taaaaaagct gcgcctactt gctgaaacac caacgcccat
     3421 actccataac ctttaaatgc cataatgaaa ccaacaattc ccgttaacaa ctgcgtacct
     3481 aatgtaacga aacacagttc ccgaaatcta aattctacgg taagccgtgc cgtctgcgaa
     3541 attgtaagtg aattgaatac aaaaaccaaa cctagaactc tgcaaaccga ttccagcaat
     3601 ggcgtacgat aaaagtctgc tattagcgga gctgctaaaa acaatactac ataccaaaac
     3661 agacctacaa ctatattaaa ataaaagcaa gtagaataat cagtttctgt tctattttga
     3721 ttttgtatta gtgcgctacc aaatccgctg tcaagaagag tagaagctac tgctaagaaa
     3781 atggcagtca ttcctattat accataatct tctggagata gaatcctcgc aactgctatt
     3841 cctacaagaa gactaagcac ctgactacca attctttcca ccgaagtcca aaaaacaccg
     3901 ttgacagctt tatctttcat aacgtagtcg ccgctatcct aaatttactt ttttctcaaa
     3961 ccaaatacac gaagcaccat cccgccccct gactttataa acaaatatgt agcttttaga
     4021 aaagacatct tcagacctga aagatatttc tcgtaagatt catctacatc taccaccaaa
     4081 ttaccatgaa gactcgcccc cttgatcggt ttcatataat caccatattc atgcttcaac
     4141 acttcatgat atgccaaagg aacaggcaat tctattctct caaatggtat ccagactgtt
     4201 tcatcgaacc attctgtatt tctcacatat ctaggcaaat aagtaaattg aatacaacaa
     4261 ttccttgaat ttctgttaac agaatagtta cgatgaagtt gttccatgta agaataaagt
     4321 tcaatatcag tccacgaagc cttttccccc aactttcgtt tagcagaaat gtattttatc
     4381 aaattcggta tggaagagaa ccgtctcaga ggataatttc ttccccataa ataatttaga
     4441 atgcagtttc tctgttctat aagttgttct ctttcttctt tatcttcagg aaatccgtca
     4501 gctacaaata tatctataaa tatcccctga tgaaatttaa cgccgatttc tccttcatat
     4561 aacaatatca tagctgtatt gtcataacgc atctgagcat gccctctata atatcctttt
     4621 tcagtataag cacactgaaa gaatataggt tttttaaatt catccgaagc tatttctaat
     4681 aaacggtcat aatcttctct gaacataaaa aaatccatat catcatccca tggaataaat
     4741 cctttatgcc gcacagctcc cagcatcgtt ccacttattg cccatatacg aagattatat
     4801 tttttacata cctcaagaag tgccaatgtc atttctatct gtatattcca tacgtgtttg
     4861 ctttgacgcg taaccaaaaa accactccgc atctcttctt caagcgaatt tatatattgt
     4921 gtcataaaag tgtaagtaaa cggctattat tttagatcat cacttaatac tccttattca
     4981 ttgaataaac tcatagatat ctatttaata ataatctcat aaagagactt aatagtaaat
     5041 tcgcaaagtt ccacaggatt attcttcagc ctaacgggat taactgaatg ggaaagaatt
     5101 tcaatctcct ctgtcttatt aatagcaacc gggtttgtga tttccatttc tgtcaatatt
     5161 tggcgaaact tgacaacagc ttgctccaaa gttaagcacc ccatagcttt agaaatgtca
     5221 gcaaagatgc cccaaagata ttcttcaccg cgaggttcta aacatttgtt catgttcaac
     5281 aacatatatt cccatatttc tgaaagtcct actgccacag catgaccatg aggaagttta
     5341 tatagagaag taatcttata actgaaagca tgtgcggccg tagtttgagt tatgcaaatg
     5401 gcacgaccag catagttagc agccaacatg atctgttcag ctgaaaagtc tgtattttca
     5461 aaaatatact cacgccaata ctttatgatt gtctcaacag ctatcttgga ataacgcttg
     5521 ctctcgtcag tggagttcac agaccaccaa gattcaatac cttgacaaag agcatcaagc
     5581 atagtacatt tcttctgata aacgggaaga gtcttgagca actttggttc aagaatgacg
     5641 acatcaggaa taatactttt gtgcatcacg ctctgtttct taccatcatg ataaataacg
     5701 gcatagcagg tagattcaga ccctgaacct gccgtagtag gaatggcaat cagtttcacg
     5761 ccagtatctt tgtactcttg ctgcaaatag ggcttatctt ttgacatttg acaatatagc
     5821 tttacacatt tagccacgtc cattgagcta ccaccaccaa tagcaagaat tgtgtcgcat
     5881 tgagtaatct ggaaaaggtc taccccccta cagatatctt cataaagagg attagaagta
     5941 aactgatcaa acaccatgaa gggagtacca atatgttcta tcttatcctt aataccaaga
     6001 taaggaaagc tactaccaca aactaatagc accttggtag aacctttgag agcttcatta
     6061 agataatcaa ttccttgata tattatttgc atattatata aatctaactc cttaaaaaag
     6121 tcatcagagc ttccttattc tgaataggtg tagtagtggg acgacctaaa tccttgcgat
     6181 tgccctgctt gacacatgcc tgcaagaaaa ttggtccttc ttggactttg atttcaccaa
     6241 tcaattcttg tagcccctcc tttgtatcga cattataaac atgtttatac cccatagctt
     6301 tagctatagc aggtatatca atcttcaaac ctacagtagg ctgacctccg accgagtcgt
     6361 gagcaccatt attaaaaact acatgaacat agttctgagg cgctttatta gccacaatag
     6421 ccatactacc catatgcata atagaagctc catcaccatc aaaacaccac actttgcgat
     6481 cttgcttctc taaagctatg cctaaagcta tttgagaggc atgtcccata gcccctactg
     6541 tcaaaaaatc gcgctcatgt ccttgattca tagcagtacg gtactcgaag agttcacgac
     6601 ttatcatacc tgtagtagat ataatagtat cagcttcacc aagtgctgct acaactgttt
     6661 gaatagcctc ttcacgagac atcgtaaaat tatttctctc tacattttga agagtatagg
     6721 cattaaaggt gtctttttca atgataaggg catagacctc attccgttta accgcctcta
     6781 cagcttttaa tatttgcttt gcagccttgt tttcttcttt tgaaagcaca tcatagttca
     6841 ctcccataat attaagcaat ccggttgtca ccttgccctg ttttacatgt tgtggttcat
     6901 cttgcacccc aggacaacca cgccaaccaa tcagaagaag aatcggtata ttatagactt
     6961 ccttatctac tagtgaagcc aatggattta tggcatttcc ctcaccagag ttctgcatgt
     7021 atacaacacc tacctttcct gtggctaaat gataaccagc cgcaagagca acagcagcac
     7081 cttcattagc agttataatg ttgtgcctag catccatatt gtcggctatg tatccacaga
     7141 tactcttcag tagcgaatcc ggtacacctg caaaatagtc aataccatac ctatccaatt
     7201 cgtctataaa aaatttcgga ctaatcatta tattatttta tttatgtgta ctagggatga
     7261 gttcaagaat ctctttgata ggcatgcagt attctgcaga agcctctttt gaacgaccat
     7321 gtgtcaagat agacttggca caattcatca ttgctggata agatgcacga agcatgtgat
     7381 ttgcatatat taccacattt attccccatg aagccaactc ctcctctgta aactgattat
     7441 aggttgtcgg aacaaccaca atgggtatat ccgcatatct tgcacgaaat tttttacaga
     7501 attccttgat atcctcacct gttttttcct ttgaatgaat catgatacca tcaacaccag
     7561 cctccacata agcaaagcaa cgctcaatag catcagacat tggcttacct gcaataagcg
     7621 attcacaacg tgctataatc ataaagtctt cagtaatctg agcatttttg cccgccttaa
     7681 tctttgctgt aaatccttcg atagtatcct gtgtctgaat agcgtctgta ccgaatagtg
     7741 aattttgctt taatcccact ttatcctcaa tgataacagc agaaactccc agacgttcta
     7801 aagtgcgaac agtgaaaaca aaatgctcta attttccacc agtatcacca tcataaataa
     7861 acggttttgt agttacttcg agagcatcgt taagaccatg aagccgtgtc gtcaagtcga
     7921 cagcctctat atccggttta ccctttgagg tagaatcggt caatgaagat gcccacatac
     7981 cgtcgaactc acgcttcaca ttattaattt caatgcaagc attttccgca ataagaccag
     8041 taagtcctga atgactttca agaatacgta caataggctt agcagcaatc agccggcgaa
     8101 gtcttttcat tcggacttca ggggttgtac ctatctcttt cagatgttgg ttaagcaatg
     8161 aagaagaaat accttgagta taaggaatat ctataacctt acctccccat tgtgaaatgc
     8221 aatcgataac atgctgacgc gtcttctgct gaaccccctc tttccaatca tcaccgtgaa
     8281 gaacataatt tggacggatt ttctccaaat tcggtacata atcaagagta gtctgaggta
     8341 tgacttcatc cacccctttc agattctcaa caataagtga acgttgttca aatgacagat
     8401 aaggcaaccg cttgtaacta gctattgccg aatccgttaa tacccctacc acaacacgac
     8461 caagcttatt tgcctcatga attatgttga gatgccccgg gtgaattatg tcagcactca
     8521 taccgacata aacagttttt atcttatcca tattattgaa ttataatact atatagacag
     8581 ttttttatat ttaatcacat aaaaatacac cttcaaaaat tagatatatt aacatatgcc
     8641 ttcatttaaa atggcttaaa gcttttgtta ctatttgatg catatcataa tatctatatt
     8701 ctgccaatcg acctccaaaa atcacattgt tatcctgatc agccagtttc ttatatttaa
     8761 gataaagcga attattcttt tcgtcattta ctggataata aggttcgctc ccttctttcc
     8821 attctgaact gtattccttc gagataacag ttttagaaca agcctcaatg tccgccccga
     8881 acatttcaaa atgcttatgc tcaatgacac gtgtataggg aatttctttt tctgtataat
     8941 taattactgc attaccctga tagttggaca tatttaatag ctccgtttca aaatttactg
     9001 tacgatattc caacttcccg aatctatatc tataaaactc atctattgct cctgtaaata
     9061 ctatcctatc tgaaatttct tccaactcat tccggtgagc aaagaaatca tagtttagtt
     9121 tggtatctat accttccagc aagcgctcta tcagtacatt gtatccaccg ataggaattc
     9181 cctgatattt atcgttaaaa tagttgttat caaaaataaa acgtacagga agtcgtttga
     9241 tgatgaatgc gggaagatcg ctacatttgc gtccccactg tttttctgta taacccttaa
     9301 tcagcgattc ataaatatcc tttccgataa gtaactgtgc ctgctcttcc aagttgcgag
     9361 gttcaataac accttgttct ttcatgagag caatcgcctc tgccttctgt tcttcaatct
     9421 ttgcccttgc ttcagcagga gtagtgattc cccacatctg atagaaagta ttcatattga
     9481 aaggtaaatt atacagcttt cctttatagc tagctatcgg tgaattggta tagcgattga
     9541 attccacaat ggaatttaca aaatcccaca ctactttatt ggaagtatga aaaatgtgtg
     9601 ctccatattt atgaacatta ataccttcta tgttttcaca ataaatattc ccacccaaat
     9661 gagaacggcg atcaataact aaacactttt taccttgtag ttttgcttta taggcgaata
     9721 cggaaccaaa aagtccggca cctactatta agaaatcgta atgattcatg acatttctaa
     9781 ttttatttct atattacgaa atacatttaa attcgttaat atcccctctt ctaatacgca
     9841 ttcttctccc ccacaatcac attcgccaca gtcttataaa tgatatatat gtcaagcagc
     9901 attgtccagt gctccatata ccagatatca gccttaacac gttcctccat ctgtgataat
     9961 tccctcgttt caccacgaaa accatgcgtt tgagcccaac cggtcactcc aggttttata
    10021 aagtgccgca ccatatattt atcaatcaaa cgggcataaa tctccgtatg ggctaacatg
    10081 tgtggacggg gaccaactac cgacatatca cccttaaaga cattgataaa ctgagggagt
    10141 tcgtcaatat tagaacgacg gaggaaatct ccaaatcttg ttttacgggg atcatcagcc
    10201 gtagcctgtt tactgtcggc ttcatcattc actttcatcg aacggaattt ataacacaca
    10261 aaatccacac cattcaaacc cgtacgcatt tgcttaaaga atacaggacc gggagaagtc
    10321 aattttataa tacttcccac tatgagataa acaaaaggaa aaatagtaac cagaaaaaga
    10381 cctgagataa caatatcaaa tattcgcttc aatatccgat tttccatttt acccaaaggc
    10441 tcataacgca gattcaagat aggcatattg ccaaccatac tgtgccagat acgacgagga
    10501 aaacctttac atacattagg aacaccatga aaataaagca aatggttttc acaatgattc
    10561 ataatagaaa aattatagcg cccctcctcc atcgacagag aacaaaaaac atgtttgatt
    10621 cccggatgta cggacataaa gtctgaaaaa ccgtcgggat tacccagata ggaacattgg
    10681 gaggaaaagg cttcattcgg ttttatatca aaataaccca caacctcata tagggaagag
    10741 gctaaagaac tctccatctc ctcatacaac acctgcatat tattgcctcc acctataaaa
    10801 acagcataac gtctatgctt gcctttagca caatagacta tcaggaaatg acggataata
    10861 atgcgataaa tgcttagaat aacaaagagg aaagagaaat aggcaacaaa gaaaagagga
    10921 gaatagatag agattccact aaaagtcatg atacatgccc aaaagatgga aaaagctata
    10981 atattcttca acacacgcaa cacaagttgg tcagggcgaa ttccccgact atcccacacc
    11041 ctcccacggg atccagaaca ggccagatag cagagactta acgaagtcat catccatgaa
    11101 accctgcaag aaaaaggtaa agagacaaat acttcttccc aaaagaaaag gagaaagaac
    11161 aataccaggt tcagaatgat cagatctccc agaactgcta caaattctat aaatttattg
    11221 atttgactgg tggttgatac catatcacat taaaaattga ttttaggcac atacttcttt
    11281 gaacttattc agaaaatctt ttccgaatag attccaagag ataacaatac aaactgatag
    11341 gaaaataaaa gctaaaacac atactttcct actggttccc gaaggttcca aggggacaac
    11401 agcaggttct acaacagcaa acactggctt ctcttcctga actttagctc tggcaatctg
    11461 aagctgactg gcaacctggc tgtatacctg gtaagcaagg ctcatatcat tctgcaaacg
    11521 ttcctgttcg gtacgaacac tctgcaaaat gatattgtca tgagagtcca tatagtcagc
    11581 atatttcttc tgagcgacat aatattcttg ttgacgttct ttgaaaagtt tctccaaata
    11641 aatacaatcc tctttagatt tggaagtacg ataatctatg atgtattcct gcaatttctt
    11701 aaccacggaa tcggctacga ctgcagcaac tttagaatcc tgaaaagttg cagtaacgga
    11761 agtcattgaa gttttcttat ccacagaagc gacaatcttt ttctttagtg attcaatctt
    11821 ctgagattcc tttttagata attcaatggt accttgactc gctttatccg aaaaaataga
    11881 ttcatcctca tcttcgataa acaaagactt tactccgcca attaccatac caggaaaccc
    11941 gattacataa ctccaccagg gagaagattc ttcatctaaa taagaactta aagagatttt
    12001 ctcactccct gatacaggta ctttcatatt agaaagttcc aacaagaagg gagtagaaga
    12061 gacgatatct gcagataagg aagcattcaa ggcatcggtt ccatctccca tagaaactcc
    12121 acttcctaaa aatgaagcag ccaaaccgga taaaccacca cctttgttat tacccatttc
    12181 cggagaaagg gtaacttcaa ccgtgtactg cttagggata cttatcgcaa caataacacc
    12241 aattatcagt ccgataccgg ccgctttata gattttctta cgaataccta taaccttacg
    12301 aagaagatcc atcaaatcaa tttcgatctc ctcatcattg tgattattat gcaactgttt
    12361 tgtttccttc tcagatgttt gttccatcaa agtagacata aataaaggta ttcgttattt
    12421 cttgattaaa ttagcaatag aggcaaccat catacccaaa gtactgaatg tagtagcata
    12481 acttaaaata tttcccatat tggtcttctt cttagcctta ctaggcacaa ttatctcaca
    12541 tcccggttcg atctgtttct taccgctacc tttaacctta gttacctgac cattcatata
    12601 aacaatgaac ttcttgctct tcttcgcatt ttcagaataa ccaccggcct gattcaaata
    12661 ataatcaact ttctgtcctt ctatataaga aaccgtattc ggaaccatga cagcaccatt
    12721 gatcgtgacc gtattagtat tcttcggaat aaaaaccaca tcaccttcac gaagaaccaa
    12781 atctgatgca ctgccaggat tagctatagc tttctccaaa tcaatgccga ctgtaaaatg
    12841 atcttccaca cggacgccca aagaatccat catagcttct cctagctgtc gactcatcaa
    12901 acggatcaca tctcccatac gtttcttctc acctgcagta gcgacacgag tcaacttggc
    12961 accgcgtaag taagcataat tcgtagcacc tcccgcttta ttgatcaaat ctgaaagacg
    13021 ttcttcacga ctagtcatgg cgtaagaccc tccgaacagg atttcacctt caacggctac
    13081 attctgctga gcctgataac ccggactacg acgaacataa acctcatcat aaggttgaag
    13141 tacgaaaccc ggtgtgccgt cgacgacaaa gccttctttc agggagaatg tatagatctg
    13201 accaatagta tcgttatcca ctgtactacg gggattcttg attctacggg atacatccac
    13261 acgaactaca gaagcggctt cacgcaagcc tccggcctga atgatcaagt cttcaagagt
    13321 catgttgtca gcataaggat aggaatctgg tttggccact tcaccatgga ttacaacatc
    13381 acctctatct tccaaatcat ggatactagg aatataaaga atgtcgtttt tcgctaggat
    13441 gatattttga gaagtaccat ccataatggc tttaatgtca acagggataa cttcagtagt
    13501 aagatcctca cgttggcgat a
//
